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Auvinen et","confidence":1,"confidence_rate":1},{"cnt":[[344,1302],[1781,1302],[1781,1356],[344,1356]],"region":{"top_left_x":343,"top_left_y":1301,"width":1439,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b29a815f9682421ea727e859912eba7a","type":"text","conversion_output":true,"text":"al noted that the hair loss acted as a constant reminder to the patient of the underlying","text_display":" al noted that the hair loss acted as a constant reminder to the patient of the underlying","confidence":1,"confidence_rate":1},{"cnt":[[344,1351],[1835,1351],[1835,1403],[344,1403]],"region":{"top_left_x":343,"top_left_y":1351,"width":1492,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a0a7c7099af406daa02d36a2c0b4b79","type":"text","conversion_output":true,"text":"cancer and it had an impact not only on the patient, but also on those individuals close to","text_display":" cancer and it had an impact not only on the patient, but also on those individuals close to","confidence":1,"confidence_rate":1},{"cnt":[[344,1401],[1781,1401],[1781,1450],[344,1450]],"region":{"top_left_x":343,"top_left_y":1400,"width":1439,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fba85e21a2e41828cda52240d84b0de","type":"text","conversion_output":true,"text":"the patient. Among women losing their hair because of breast cancer treatment, many","text_display":" the patient. Among women losing their hair because of breast cancer treatment, many","confidence":1,"confidence_rate":1},{"cnt":[[344,1448],[1826,1448],[1826,1497],[344,1497]],"region":{"top_left_x":343,"top_left_y":1448,"width":1484,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"636923edd9b940eb9bc622c449292c9c","type":"text","conversion_output":true,"text":"indicate that coping with hair loss is more difficult than the loss of their breast since it is","text_display":" indicate that coping with hair loss is more difficult than the loss of their breast since it is","confidence":1,"confidence_rate":1},{"cnt":[[344,1495],[1796,1495],[1796,1545],[344,1545]],"region":{"top_left_x":343,"top_left_y":1495,"width":1454,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"366831a34c2d472fb55f7b94ea788e73","type":"text","conversion_output":true,"text":"outwardly visible to others, affects their femininity, and is a constant reminder of their","text_display":" outwardly visible to others, affects their femininity, and is a constant reminder of their","confidence":0.998046875,"confidence_rate":0.9999794208976915},{"cnt":[[344,1543],[1841,1543],[1841,1592],[344,1592]],"region":{"top_left_x":343,"top_left_y":1542,"width":1499,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66e4fe04bc6c450c8107f68f1ef8fa07","type":"text","conversion_output":true,"text":"cancer (Kaderman 1999; Benjamin 2002). In 2011, Breed et al noted that \\(13 \\%\\) of women","text_display":" cancer (Kaderman 1999; Benjamin 2002). In 2011, Breed et al noted that \\(13 \\%\\) of women","confidence":1,"confidence_rate":1},{"cnt":[[344,1590],[1863,1590],[1863,1641],[344,1641]],"region":{"top_left_x":343,"top_left_y":1589,"width":1520,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbc3c627e8b742d398c850730a0ac8d3","type":"text","conversion_output":true,"text":"cancer patients surveyed believed they would be rejected by their partner in the event they","text_display":" cancer patients surveyed believed they would be rejected by their partner in the event they","confidence":1,"confidence_rate":1},{"cnt":[[344,1639],[1820,1639],[1820,1691],[344,1691]],"region":{"top_left_x":343,"top_left_y":1639,"width":1477,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e31a7926b4cc41e0ae632e040ea43e0c","type":"text","conversion_output":true,"text":"experienced hair loss resulting from chemotherapy. Trueb reported in 2010 that \\(47 \\%\\) of","text_display":" experienced hair loss resulting from chemotherapy. Trueb reported in 2010 that \\(47 \\%\\) of","confidence":0.9921875,"confidence_rate":0.9999183035721159},{"cnt":[[344,1689],[1794,1689],[1794,1738],[344,1738]],"region":{"top_left_x":343,"top_left_y":1688,"width":1451,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acd560bb17834aada85b5bd00f1514e3","type":"text","conversion_output":true,"text":"women cancer patients considered chemotherapy-induced hair loss the most traumatic","text_display":" women cancer patients considered chemotherapy-induced hair loss the most traumatic","confidence":1,"confidence_rate":1},{"cnt":[[344,1736],[1858,1736],[1858,1785],[344,1785]],"region":{"top_left_x":343,"top_left_y":1735,"width":1516,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0827100126b43a2a07c0cff7aaf4210","type":"text","conversion_output":true,"text":"aspect of cancer treatment. Furthermore, \\(8 \\%\\) of women surveyed reported that they would","text_display":" aspect of cancer treatment. Furthermore, \\(8 \\%\\) of women surveyed reported that they would","confidence":0.9921875,"confidence_rate":0.999916565422762},{"cnt":[[344,1783],[1841,1783],[1841,1833],[344,1833]],"region":{"top_left_x":343,"top_left_y":1783,"width":1499,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdcc29dee73543b7bbe4cc9ed3b31435","type":"text","conversion_output":true,"text":"actually decline chemotherapy because of the fear of this side-effect, despite the fact that","text_display":" actually decline chemotherapy because of the fear of this side-effect, despite the fact that","confidence":1,"confidence_rate":1},{"cnt":[[344,1830],[1781,1830],[1781,1882],[344,1882]],"region":{"top_left_x":343,"top_left_y":1830,"width":1439,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39f91f8040f6426dac0bacef63ba7f3f","type":"text","conversion_output":true,"text":"the hair loss is nearly always temporary. This may lead to women hesitating in taking","text_display":" the hair loss is nearly always temporary. This may lead to women hesitating in taking","confidence":1,"confidence_rate":1},{"cnt":[[344,1878],[1863,1878],[1863,1931],[344,1931]],"region":{"top_left_x":343,"top_left_y":1877,"width":1520,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c958705eafc49b5963efd3c7ada807d","type":"text","conversion_output":true,"text":"chemotherapy, which may compromise their outcome. This side effect of chemotherapy is","text_display":" chemotherapy, which may compromise their outcome. This side effect of chemotherapy is","confidence":1,"confidence_rate":1},{"cnt":[[344,1927],[1745,1927],[1745,1979],[344,1979]],"region":{"top_left_x":343,"top_left_y":1927,"width":1402,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8479065cad914a4d961cc038eefd52aa","type":"text","conversion_output":true,"text":"mostly, but not always, reversible (Massey 2004). It takes months to years after the","text_display":" mostly, but not always, reversible (Massey 2004). It takes months to years after the","confidence":1,"confidence_rate":1},{"cnt":[[344,1972],[1818,1972],[1818,2026],[344,2026]],"region":{"top_left_x":343,"top_left_y":1972,"width":1475,"height":54},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e245dc52398b416dbda775426a9f2714","type":"text","conversion_output":true,"text":"completion of chemotherapy for the hair to recover, and it may be of a different quality,","text_display":" completion of chemotherapy for the hair to recover, and it may be of a different quality,","confidence":1,"confidence_rate":1},{"cnt":[[344,2024],[698,2024],[698,2073],[344,2073]],"region":{"top_left_x":343,"top_left_y":2023,"width":356,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"831468c7c2fc4b11b184535e667e5782","type":"text","conversion_output":true,"text":"color, and thickness.","text_display":" color, and thickness.","confidence":1,"confidence_rate":1},{"cnt":[[346,2110],[1594,2110],[1594,2181],[346,2181]],"region":{"top_left_x":345,"top_left_y":2109,"width":1250,"height":72},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6ce7d6b458b4f9caeb0488d5d59344c","type":"section_header","conversion_output":false,"children_ids":["f793b017bd3f47a0afe54f6971232cb7"],"text":"","text_display":""},{"cnt":[[352,2116],[1583,2116],[1583,2172],[352,2172]],"region":{"top_left_x":352,"top_left_y":2116,"width":1232,"height":57},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f793b017bd3f47a0afe54f6971232cb7","type":"text","conversion_output":true,"parent_id":"e6ce7d6b458b4f9caeb0488d5d59344c","text":"C. 2 Methods for Management of Chemotherapy-Induced Alopecia","text_display":"\n\n\\section*{C. 2 Methods for Management of Chemotherapy-Induced Alopecia}","confidence":1,"confidence_rate":1},{"cnt":[[346,2187],[1775,2187],[1775,2237],[346,2237]],"region":{"top_left_x":345,"top_left_y":2187,"width":1430,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1199b4820614105ad1254c08e3a273c","type":"text","conversion_output":true,"text":"Chemotherapy-induced alopecia is caused by the fact that chemotherapy relies for its","text_display":"\n\nChemotherapy-induced alopecia is caused by the fact that chemotherapy relies for its","confidence":1,"confidence_rate":1},{"cnt":[[344,2234],[1869,2234],[1869,2288],[344,2288]],"region":{"top_left_x":343,"top_left_y":2234,"width":1527,"height":55},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43cde2a732b74a36bc2842fee46b1c47","type":"text","conversion_output":true,"text":"effectiveness on the ability of drugs used to inhibit and suppress growth and multiplication","text_display":" effectiveness on the ability of drugs used to inhibit and suppress growth and multiplication","confidence":1,"confidence_rate":1},{"cnt":[[344,2282],[1867,2282],[1867,2333],[344,2333]],"region":{"top_left_x":343,"top_left_y":2281,"width":1524,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c1478e1efd94edd8b5cab3240b0bc3c","type":"text","conversion_output":true,"text":"of rapidly dividing cancer cells. These drugs are not able to distinguish between cancerous","text_display":" of rapidly dividing cancer cells. These drugs are not able to distinguish between cancerous","confidence":1,"confidence_rate":1},{"cnt":[[344,2331],[1841,2331],[1841,2383],[344,2383]],"region":{"top_left_x":343,"top_left_y":2331,"width":1499,"height":52},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bdf0407d2944787ac90242214175025","type":"text","conversion_output":true,"text":"cells \\& non-cancerous cells i.e. hair follicles. At any one time, approximately \\(85-90 \\%\\) of","text_display":" cells \\& non-cancerous cells i.e. hair follicles. At any one time, approximately \\(85-90 \\%\\) of","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[344,2378],[1841,2378],[1841,2430],[344,2430]],"region":{"top_left_x":343,"top_left_y":2378,"width":1499,"height":52},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b5efe283d704e5897d5a486445c9ad0","type":"text","conversion_output":true,"text":"human hair follicles are in a state of rapid growth (Massey 2004). Numerous measures to","text_display":" human hair follicles are in a state of rapid growth (Massey 2004). Numerous measures to","confidence":1,"confidence_rate":1},{"cnt":[[344,2428],[1807,2428],[1807,2479],[344,2479]],"region":{"top_left_x":343,"top_left_y":2427,"width":1464,"height":53},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f970acd6df6449085d79276753022e4","type":"text","conversion_output":true,"text":"prevent or reduce the effects of chemotherapy-induced alopecia, including mechanical,","text_display":" prevent or reduce the effects of chemotherapy-induced alopecia, including mechanical,","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1091,2557],[1091,2610],[1038,2610]],"region":{"top_left_x":1037,"top_left_y":2556,"width":55,"height":55},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76469639abe14b6899964b56d7435790","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-11","page":11,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd9ab9d4b9e048468908b88fbe85861a","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef2eb6a96c55450687a05975f5e37f72","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[344,251],[1755,251],[1755,303],[344,303]],"region":{"top_left_x":343,"top_left_y":251,"width":1413,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45c44692d3284b80875c169b741da98d","type":"text","conversion_output":true,"text":"pharmacological and physical methods, have been investigated since the 1960s with","text_display":"\npharmacological and physical methods, have been investigated since the 1960s with","confidence":1,"confidence_rate":1},{"cnt":[[344,301],[1068,301],[1068,350],[344,350]],"region":{"top_left_x":343,"top_left_y":300,"width":725,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddf6e0a3146e40b4b10928fbc4c28c28","type":"text","conversion_output":true,"text":"varying degrees of success (Massey 2004).","text_display":" varying degrees of success (Massey 2004).","confidence":1,"confidence_rate":1},{"cnt":[[344,370],[1876,370],[1876,419],[344,419]],"region":{"top_left_x":343,"top_left_y":369,"width":1533,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8470c634bed2487d97202623f79e0cd5","type":"text","conversion_output":true,"text":"Breed reports that in the late 1970s scalp tourniquets were utilized to reduce the blood flow","text_display":"\n\nBreed reports that in the late 1970s scalp tourniquets were utilized to reduce the blood flow","confidence":1,"confidence_rate":1},{"cnt":[[344,417],[1833,417],[1833,466],[344,466]],"region":{"top_left_x":343,"top_left_y":416,"width":1490,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbb6995e26d447979f6ce16c075f376e","type":"text","conversion_output":true,"text":"to hair follicles during peak chemotherapy levels (Breed 2011). Hair loss was reduced in","text_display":" to hair follicles during peak chemotherapy levels (Breed 2011). Hair loss was reduced in","confidence":1,"confidence_rate":1},{"cnt":[[344,466],[1833,466],[1833,518],[344,518]],"region":{"top_left_x":343,"top_left_y":466,"width":1490,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d52c19ee8580438a82f2b1e75f189b69","type":"text","conversion_output":true,"text":"patients receiving doxorubicin. This approach was associated with side effects including","text_display":" patients receiving doxorubicin. This approach was associated with side effects including","confidence":1,"confidence_rate":1},{"cnt":[[344,511],[1841,511],[1841,563],[344,563]],"region":{"top_left_x":343,"top_left_y":511,"width":1499,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8573f7edd9a44c0ca782ecba736b7680","type":"text","conversion_output":true,"text":"headache and nerve compression and is no longer utilized. A number of pharmacological","text_display":" headache and nerve compression and is no longer utilized. A number of pharmacological","confidence":1,"confidence_rate":1},{"cnt":[[344,561],[1775,561],[1775,612],[344,612]],"region":{"top_left_x":343,"top_left_y":560,"width":1432,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78d85c0615fe41929d4f7e5813003848","type":"text","conversion_output":true,"text":"agents with different mechanisms of action have been studied over the years for their","text_display":" agents with different mechanisms of action have been studied over the years for their","confidence":1,"confidence_rate":1},{"cnt":[[344,608],[1714,608],[1714,660],[344,660]],"region":{"top_left_x":343,"top_left_y":608,"width":1372,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b22008f1c383434b958d6405cb8cc0d0","type":"text","conversion_output":true,"text":"effects to minimize chemotherapy-induced hair loss. Of the agents that have been","text_display":" effects to minimize chemotherapy-induced hair loss. Of the agents that have been","confidence":1,"confidence_rate":1},{"cnt":[[344,657],[1835,657],[1835,707],[344,707]],"region":{"top_left_x":343,"top_left_y":657,"width":1492,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3013323ab2c94edb87467269bb760758","type":"text","conversion_output":true,"text":"evaluated in humans, two - AS101 (an immune modulator) and minoxidil (a hair growth","text_display":" evaluated in humans, two - AS101 (an immune modulator) and minoxidil (a hair growth","confidence":1,"confidence_rate":1},{"cnt":[[344,705],[1880,705],[1880,754],[344,754]],"region":{"top_left_x":343,"top_left_y":704,"width":1537,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1547b41939a947839f5794a07e4a030e","type":"text","conversion_output":true,"text":"promoter) - were able to reduce the severity and shorten the duration of alopecia, but could","text_display":" promoter) - were able to reduce the severity and shorten the duration of alopecia, but could","confidence":1,"confidence_rate":1},{"cnt":[[344,752],[1794,752],[1794,801],[344,801]],"region":{"top_left_x":343,"top_left_y":751,"width":1451,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10b3692ef0f84f70b61e3aee4ca5bd95","type":"text","conversion_output":true,"text":"not prevent it (Wang 2006). Trueb reported in 2009 that \\(2 \\%\\) topical minoxidil solution","text_display":" not prevent it (Wang 2006). Trueb reported in 2009 that \\(2 \\%\\) topical minoxidil solution","confidence":0.9936623573303223,"confidence_rate":0.9999337749973021},{"cnt":[[344,799],[1652,799],[1652,849],[344,849]],"region":{"top_left_x":343,"top_left_y":799,"width":1310,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eda226e760e4cd9ba5c329aa01c6426","type":"text","conversion_output":true,"text":"shortened the duration of alopecia in breast cancer patients receiving adjuvant","text_display":" shortened the duration of alopecia in breast cancer patients receiving adjuvant","confidence":1,"confidence_rate":1},{"cnt":[[344,846],[1790,846],[1790,900],[344,900]],"region":{"top_left_x":343,"top_left_y":846,"width":1447,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60bf2299d4b04250937ae284cd0b7b64","type":"text","conversion_output":true,"text":"chemotherapy (Trueb 2009). It was not effective in preventing chemotherapy-induced","text_display":" chemotherapy (Trueb 2009). It was not effective in preventing chemotherapy-induced","confidence":1,"confidence_rate":1},{"cnt":[[344,898],[1371,898],[1371,947],[344,947]],"region":{"top_left_x":343,"top_left_y":898,"width":1028,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93576bb368db4c8b91ad71bc73b4c3cb","type":"text","conversion_output":true,"text":"alopecia when doxorubicin was used as part of the treatment.","text_display":" alopecia when doxorubicin was used as part of the treatment.","confidence":1,"confidence_rate":1},{"cnt":[[344,965],[1772,965],[1772,1016],[344,1016]],"region":{"top_left_x":343,"top_left_y":964,"width":1430,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"481a8827fc1840e4b6592613b8fd5896","type":"text","conversion_output":true,"text":"Physical methods employed to reduce chemotherapy-induced alopecia have included","text_display":"\nPhysical methods employed to reduce chemotherapy-induced alopecia have included","confidence":1,"confidence_rate":1},{"cnt":[[344,1010],[1837,1010],[1837,1063],[344,1063]],"region":{"top_left_x":343,"top_left_y":1009,"width":1494,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ce629aa590e42599f4735bcc96a37cb","type":"text","conversion_output":true,"text":"electrotrichiogenesis and scalp cooling. The former was reported in 2002 with promising","text_display":" electrotrichiogenesis and scalp cooling. The former was reported in 2002 with promising","confidence":1,"confidence_rate":1},{"cnt":[[344,1061],[1869,1061],[1869,1111],[344,1111]],"region":{"top_left_x":343,"top_left_y":1061,"width":1527,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1399125b49a4bd2a7915567cd849655","type":"text","conversion_output":true,"text":"results in a pilot study, but no further results have been published (Christodoulou 2006). In","text_display":" results in a pilot study, but no further results have been published (Christodoulou 2006). In","confidence":1,"confidence_rate":1},{"cnt":[[344,1109],[1854,1109],[1854,1158],[344,1158]],"region":{"top_left_x":343,"top_left_y":1108,"width":1512,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"247d84802baf4f508ed849e2fd3acd73","type":"text","conversion_output":true,"text":"an increasing number of European countries, scalp cooling has been introduced to prevent","text_display":" an increasing number of European countries, scalp cooling has been introduced to prevent","confidence":1,"confidence_rate":1},{"cnt":[[344,1156],[1611,1156],[1611,1205],[344,1205]],"region":{"top_left_x":343,"top_left_y":1155,"width":1269,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca7915dc5e3d4d058253440f1cf21dc7","type":"text","conversion_output":true,"text":"or reduce chemotherapy-induced alopecia. Scalp cooling cause's cutaneous","text_display":" or reduce chemotherapy-induced alopecia. Scalp cooling cause's cutaneous","confidence":1,"confidence_rate":1},{"cnt":[[344,1203],[1800,1203],[1800,1255],[344,1255]],"region":{"top_left_x":343,"top_left_y":1203,"width":1458,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6da6c4a1893f4108aa2d87baa8e2e552","type":"text","conversion_output":true,"text":"vasoconstriction, which reduces the blood flow to the hair follicles during peak plasma","text_display":" vasoconstriction, which reduces the blood flow to the hair follicles during peak plasma","confidence":1,"confidence_rate":1},{"cnt":[[344,1250],[1807,1250],[1807,1302],[344,1302]],"region":{"top_left_x":343,"top_left_y":1250,"width":1464,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c1435ef551f46bab77ca450ce6f60a3","type":"text","conversion_output":true,"text":"concentrations of the chemotherapeutic agents and therefore reduces cellular uptake of","text_display":" concentrations of the chemotherapeutic agents and therefore reduces cellular uptake of","confidence":1,"confidence_rate":1},{"cnt":[[344,1300],[1867,1300],[1867,1351],[344,1351]],"region":{"top_left_x":343,"top_left_y":1299,"width":1524,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5a7bb13d7e044eca9092a4a91d7310a","type":"text","conversion_output":true,"text":"these agents. It also results in reduced biochemical activity, which makes hair follicles less","text_display":" these agents. It also results in reduced biochemical activity, which makes hair follicles less","confidence":1,"confidence_rate":1},{"cnt":[[344,1347],[1583,1347],[1583,1399],[344,1399]],"region":{"top_left_x":343,"top_left_y":1347,"width":1241,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d4b6c119d73404cac7bf8b5eded425b","type":"text","conversion_output":true,"text":"susceptible to the damage of the chemotherapy agents (Grevelman 2005).","text_display":" susceptible to the damage of the chemotherapy agents (Grevelman 2005).","confidence":1,"confidence_rate":1},{"cnt":[[344,1416],[1762,1416],[1762,1467],[344,1467]],"region":{"top_left_x":343,"top_left_y":1415,"width":1419,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebe01cf570b841f990663bd2068a8835","type":"text","conversion_output":true,"text":"Scalp cooling was at first performed using crushed ice packs that were placed on the","text_display":"\nScalp cooling was at first performed using crushed ice packs that were placed on the","confidence":1,"confidence_rate":1},{"cnt":[[344,1465],[1833,1465],[1833,1515],[344,1515]],"region":{"top_left_x":343,"top_left_y":1465,"width":1490,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad2007f8f7174295922f3f49ce54ec7d","type":"text","conversion_output":true,"text":"patient's head, but with unsatisfactory results. The ice packs were subsequently replaced","text_display":" patient's head, but with unsatisfactory results. The ice packs were subsequently replaced","confidence":1,"confidence_rate":1},{"cnt":[[344,1512],[1846,1512],[1846,1566],[344,1566]],"region":{"top_left_x":343,"top_left_y":1512,"width":1503,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dba382dbe3f24dda9660daf9eda4c905","type":"text","conversion_output":true,"text":"with cryogel ice caps (ChemoCap, Elasto-Gel, Hypothermia Cap and Penguin Cold Cap).","text_display":" with cryogel ice caps (ChemoCap, Elasto-Gel, Hypothermia Cap and Penguin Cold Cap).","confidence":1,"confidence_rate":1},{"cnt":[[344,1560],[1867,1560],[1867,1611],[344,1611]],"region":{"top_left_x":343,"top_left_y":1559,"width":1524,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da63fef33e0543dca4dd8fcee4537c54","type":"text","conversion_output":true,"text":"Since the caps are put on freezing cold, and thaw over time, they are uncomfortable for the","text_display":" Since the caps are put on freezing cold, and thaw over time, they are uncomfortable for the","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[344,1607],[1833,1607],[1833,1661],[344,1661]],"region":{"top_left_x":343,"top_left_y":1607,"width":1490,"height":54},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa0dc6b46fd7406b92758078396129fe","type":"text","conversion_output":true,"text":"patient and also very labor-intensive for the nurse. The fluctuation in temperature affects","text_display":" patient and also very labor-intensive for the nurse. The fluctuation in temperature affects","confidence":1,"confidence_rate":1},{"cnt":[[344,1659],[1837,1659],[1837,1708],[344,1708]],"region":{"top_left_x":343,"top_left_y":1658,"width":1494,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0adb3e804bcb4b879a818fa75eff51bc","type":"text","conversion_output":true,"text":"the results of the scalp cooling treatment. This led to the development of cooling systems","text_display":" the results of the scalp cooling treatment. This led to the development of cooling systems","confidence":0.99609375,"confidence_rate":0.9999588019084422},{"cnt":[[344,1706],[1227,1706],[1227,1755],[344,1755]],"region":{"top_left_x":343,"top_left_y":1705,"width":884,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8d9173979564148b16f9a6bb29f20ea","type":"text","conversion_output":true,"text":"that could provide a continuous cooling of the scalp.","text_display":" that could provide a continuous cooling of the scalp.","confidence":0.92822265625,"confidence_rate":0.9987166234799746},{"cnt":[[344,1772],[1751,1772],[1751,1824],[344,1824]],"region":{"top_left_x":343,"top_left_y":1772,"width":1408,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52e77d0b9e5f4057ac4021b145eb92a0","type":"text","conversion_output":true,"text":"Continuous scalp cooling relies on circulation of a liquid coolant. Available options","text_display":"\nContinuous scalp cooling relies on circulation of a liquid coolant. Available options","confidence":1,"confidence_rate":1},{"cnt":[[344,1818],[1781,1818],[1781,1871],[344,1871]],"region":{"top_left_x":343,"top_left_y":1817,"width":1439,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a2ece89ea554b78b17776a925e43e55","type":"text","conversion_output":true,"text":"include the Orbis and Paxman Scalp Cooling models of scalp cooler manufactured by","text_display":" include the Orbis and Paxman Scalp Cooling models of scalp cooler manufactured by","confidence":1,"confidence_rate":1},{"cnt":[[344,1869],[1515,1869],[1515,1919],[344,1919]],"region":{"top_left_x":343,"top_left_y":1869,"width":1172,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"075c11045fd044709ae3050e314ddaf4","type":"text","conversion_output":true,"text":"Paxman Coolers and the DigniCap system manufactured by Digitana.","text_display":" Paxman Coolers and the DigniCap system manufactured by Digitana.","confidence":1,"confidence_rate":1},{"cnt":[[346,1955],[1813,1955],[1813,2071],[346,2071]],"region":{"top_left_x":345,"top_left_y":1955,"width":1469,"height":117},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f09ca86d8ee4f56a99668fc2b732e8d","type":"section_header","conversion_output":false,"children_ids":["31a25ff7c3ca4e83ab3a78f8a970dd74","75be04afbddc45be8a414363cdd7625e"],"text":"","text_display":""},{"cnt":[[352,1962],[1807,1962],[1807,2017],[352,2017]],"region":{"top_left_x":352,"top_left_y":1961,"width":1455,"height":57},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31a25ff7c3ca4e83ab3a78f8a970dd74","type":"text","conversion_output":true,"parent_id":"5f09ca86d8ee4f56a99668fc2b732e8d","text":"C. 3 Effectiveness of Scalp Cooling in the Prevention of Chemotherapy-Induced","text_display":"\n\n\\section*{C. 3 Effectiveness of Scalp Cooling in the Prevention of Chemotherapy-Induced","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[460,2015],[629,2015],[629,2065],[460,2065]],"region":{"top_left_x":459,"top_left_y":2015,"width":171,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75be04afbddc45be8a414363cdd7625e","type":"text","conversion_output":true,"parent_id":"5f09ca86d8ee4f56a99668fc2b732e8d","text":"Alopecia","text_display":" Alopecia}","confidence":1,"confidence_rate":1},{"cnt":[[344,2082],[1863,2082],[1863,2133],[344,2133]],"region":{"top_left_x":343,"top_left_y":2081,"width":1520,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3716e165c0a4b82832d5ac0e055db85","type":"text","conversion_output":true,"text":"The efficacy of scalp cooling depends on several factors: chemotherapy regimen and dose,","text_display":"\n\nThe efficacy of scalp cooling depends on several factors: chemotherapy regimen and dose,","confidence":0.9965846532722935,"confidence_rate":0.9999632136622468},{"cnt":[[344,2129],[1813,2129],[1813,2181],[344,2181]],"region":{"top_left_x":343,"top_left_y":2129,"width":1471,"height":52},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73692a75f3c24855982c14e572ea1fca","type":"text","conversion_output":true,"text":"dose interval, performance status of the patient, scalp cooling temperature, post cooling","text_display":" dose interval, performance status of the patient, scalp cooling temperature, post cooling","confidence":1,"confidence_rate":1},{"cnt":[[344,2179],[1880,2179],[1880,2228],[344,2228]],"region":{"top_left_x":343,"top_left_y":2178,"width":1537,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0063867af3b4e9bbd07ea4f89cd893d","type":"text","conversion_output":true,"text":"time, and scalp cooling system (Lemieux 2008). Comfort and ease of use are also factors in","text_display":" time, and scalp cooling system (Lemieux 2008). Comfort and ease of use are also factors in","confidence":1,"confidence_rate":1},{"cnt":[[344,2226],[1824,2226],[1824,2275],[344,2275]],"region":{"top_left_x":343,"top_left_y":2225,"width":1482,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"196cc92d7304449aa35d3d9aed05ac41","type":"text","conversion_output":true,"text":"success, as discomfort or difficulties with cooling or changing the cap can result in poor","text_display":" success, as discomfort or difficulties with cooling or changing the cap can result in poor","confidence":1,"confidence_rate":1},{"cnt":[[344,2273],[1865,2273],[1865,2322],[344,2322]],"region":{"top_left_x":343,"top_left_y":2273,"width":1522,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8129fe17187a414597760e0fbe4cd63d","type":"text","conversion_output":true,"text":"compliance. Most studies looking at scalp cooling utilize the WHO Criteria for hair loss to","text_display":" compliance. Most studies looking at scalp cooling utilize the WHO Criteria for hair loss to","confidence":1,"confidence_rate":1},{"cnt":[[344,2320],[1798,2320],[1798,2374],[344,2374]],"region":{"top_left_x":343,"top_left_y":2320,"width":1456,"height":55},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00684b6fa68f47bbb1c18c74dea56cd3","type":"text","conversion_output":true,"text":"grade alopecia or a variation of this. Hair loss is rated grade 0 (no significant hair loss)","text_display":" grade alopecia or a variation of this. Hair loss is rated grade 0 (no significant hair loss)","confidence":1,"confidence_rate":1},{"cnt":[[344,2368],[1858,2368],[1858,2419],[344,2419]],"region":{"top_left_x":343,"top_left_y":2367,"width":1516,"height":53},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e01ba87f354648659800856f925524df","type":"text","conversion_output":true,"text":"through grade 4 (non-reversible alopecia). Success is commonly defined as the patient not","text_display":" through grade 4 (non-reversible alopecia). Success is commonly defined as the patient not","confidence":1,"confidence_rate":1},{"cnt":[[344,2417],[952,2417],[952,2469],[344,2469]],"region":{"top_left_x":343,"top_left_y":2416,"width":609,"height":53},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"480087ff24fa41d7b1fe908c2468a290","type":"text","conversion_output":true,"text":"requiring a wig (grades 0,1 , and 2 ).","text_display":" requiring a wig (grades 0,1 , and 2 ).","confidence":0.99951171875,"confidence_rate":0.9999900326925697},{"cnt":[[1038,2557],[1089,2557],[1089,2610],[1038,2610]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":55},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9646cad4b2d54e7ba923689f772ac43c","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-12","page":12,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75c9693173c4470f97622a601c255fc3","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b615f66190f43a5a4064d7d4760181c","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[344,251],[1854,251],[1854,303],[344,303]],"region":{"top_left_x":343,"top_left_y":251,"width":1512,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0d6c02669824e5f9536a55a60a0be8a","type":"text","conversion_output":true,"text":"There are several review articles looking at scalp cooling. One of the first is the review by","text_display":"\n\nThere are several review articles looking at scalp cooling. One of the first is the review by","confidence":0.9970722198486328,"confidence_rate":0.9999700813201886},{"cnt":[[346,301],[1826,301],[1826,350],[346,350]],"region":{"top_left_x":345,"top_left_y":300,"width":1482,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edbb20a7de9e41ed954a018b15dfdcfc","type":"text","conversion_output":true,"text":"Grevelman and Breed looking at the efficacy of scalp cooling. Included were 53 studies","text_display":" Grevelman and Breed looking at the efficacy of scalp cooling. Included were 53 studies","confidence":1,"confidence_rate":1},{"cnt":[[344,348],[1764,348],[1764,397],[344,397]],"region":{"top_left_x":343,"top_left_y":348,"width":1421,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54343e7b0e4447d081a281c982ccab6f","type":"text","conversion_output":true,"text":"and 3 personal communications in which over 2,610 patients were treated with scalp","text_display":" and 3 personal communications in which over 2,610 patients were treated with scalp","confidence":0.986328125,"confidence_rate":0.9998470539667246},{"cnt":[[344,395],[1841,395],[1841,445],[344,445]],"region":{"top_left_x":343,"top_left_y":395,"width":1499,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10125037955a40999f0b615dbf1fdd65","type":"text","conversion_output":true,"text":"cooling. The efficacy in terms of good hair preservation was \\(56 \\%\\) for studies before 1995","text_display":" cooling. The efficacy in terms of good hair preservation was \\(56 \\%\\) for studies before 1995","confidence":0.99658203125,"confidence_rate":0.9999639604036571},{"cnt":[[344,443],[1826,443],[1826,494],[344,494]],"region":{"top_left_x":343,"top_left_y":442,"width":1484,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3b20bebac13423e9a9a0b3adbcf181c","type":"text","conversion_output":true,"text":"and \\(73 \\%\\) for studies carried out from 1995 to 2005. The improvement of results is likely","text_display":" and \\(73 \\%\\) for studies carried out from 1995 to 2005. The improvement of results is likely","confidence":0.9921910762786865,"confidence_rate":0.9999200075564114},{"cnt":[[344,490],[1588,490],[1588,544],[344,544]],"region":{"top_left_x":343,"top_left_y":489,"width":1245,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"baab4d05b9fd4334bf054bb70eaaee70","type":"text","conversion_output":true,"text":"due to improved scalp cooling systems and techniques (Grevelman 2005).","text_display":" due to improved scalp cooling systems and techniques (Grevelman 2005).","confidence":1,"confidence_rate":1},{"cnt":[[344,559],[1772,559],[1772,610],[344,610]],"region":{"top_left_x":343,"top_left_y":558,"width":1430,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"245751a03eba4b36aafffafa70174949","type":"text","conversion_output":true,"text":"In 2011, Breed, et al reported on a review of 60 scalp cooling studies, which used the","text_display":"\nIn 2011, Breed, et al reported on a review of 60 scalp cooling studies, which used the","confidence":1,"confidence_rate":1},{"cnt":[[344,608],[1813,606],[1813,657],[344,659]],"region":{"top_left_x":343,"top_left_y":605,"width":1471,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e94655edf69e4abcaefc860f73af6b65","type":"text","conversion_output":true,"text":"various techniques described above and were published between 1977 and 2010 (Breed","text_display":" various techniques described above and were published between 1977 and 2010 (Breed","confidence":1,"confidence_rate":1},{"cnt":[[344,655],[1828,655],[1828,707],[344,707]],"region":{"top_left_x":343,"top_left_y":655,"width":1486,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ed86730634c409d9e00f94d7b874a44","type":"text","conversion_output":true,"text":"2011). Included in the review were 7 randomized, controlled studies, 7 non-randomized,","text_display":" 2011). Included in the review were 7 randomized, controlled studies, 7 non-randomized,","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[344,705],[1848,705],[1848,754],[344,754]],"region":{"top_left_x":343,"top_left_y":704,"width":1505,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e8153e48af443d79a5d0dfaad193bf4","type":"text","conversion_output":true,"text":"controlled studies with statistical analysis, 11 non-randomized, controlled studies without","text_display":" controlled studies with statistical analysis, 11 non-randomized, controlled studies without","confidence":1,"confidence_rate":1},{"cnt":[[344,752],[1725,752],[1725,801],[344,801]],"region":{"top_left_x":343,"top_left_y":751,"width":1383,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba0011d19adc4e528ad233c9291a92ff","type":"text","conversion_output":true,"text":"statistical analysis, and 36 non-controlled studies. In six of the seven randomized,","text_display":" statistical analysis, and 36 non-controlled studies. In six of the seven randomized,","confidence":1,"confidence_rate":1},{"cnt":[[344,799],[1790,799],[1790,849],[344,849]],"region":{"top_left_x":343,"top_left_y":799,"width":1447,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"557e49007e2047409c1ddb25d2f23123","type":"text","conversion_output":true,"text":"controlled studies, which included 111 scalp-cooled patients, scalp cooling resulted in","text_display":" controlled studies, which included 111 scalp-cooled patients, scalp cooling resulted in","confidence":1,"confidence_rate":1},{"cnt":[[344,849],[1768,849],[1768,896],[344,896]],"region":{"top_left_x":343,"top_left_y":848,"width":1426,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cf5562eb76c41f7a57984935a60f551","type":"text","conversion_output":true,"text":"significantly better hair preservation than controls. The proportion of treated patients","text_display":" significantly better hair preservation than controls. The proportion of treated patients","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[344,896],[1775,896],[1775,947],[344,947]],"region":{"top_left_x":343,"top_left_y":895,"width":1432,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56cfed3435064b53bf6f2dcc9415acdb","type":"text","conversion_output":true,"text":"having good hair preservation (WHO grade 0-2) ranged from \\(25 \\%\\) to \\(100 \\%\\). The non-","text_display":" having good hair preservation (WHO grade 0-2) ranged from \\(25 \\%\\) to \\(100 \\%\\). The non","confidence":0.7074882159594154,"confidence_rate":0.9962046458466516},{"cnt":[[344,941],[1848,941],[1848,993],[344,993]],"region":{"top_left_x":343,"top_left_y":941,"width":1505,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06ab82dbcee0436f9edd323026458d7d","type":"text","conversion_output":true,"text":"randomized, controlled studies with statistical analysis resulted in significantly better hair","text_display":"randomized, controlled studies with statistical analysis resulted in significantly better hair","confidence":1,"confidence_rate":1},{"cnt":[[344,993],[1833,993],[1833,1042],[344,1042]],"region":{"top_left_x":343,"top_left_y":992,"width":1490,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d5d798ac8844dc9bafc1ad014ce0b92","type":"text","conversion_output":true,"text":"preservation following scalp-cooling in all seven studies. This dataset included a total of","text_display":" preservation following scalp-cooling in all seven studies. This dataset included a total of","confidence":1,"confidence_rate":1},{"cnt":[[348,1040],[1824,1040],[1824,1089],[348,1089]],"region":{"top_left_x":348,"top_left_y":1039,"width":1477,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7adcc4de23f045e7b71ea62a53ac5afc","type":"text","conversion_output":true,"text":"1207 scalp-cooled patients, including 770 from a single study. The proportion of treated","text_display":" 1207 scalp-cooled patients, including 770 from a single study. The proportion of treated","confidence":1,"confidence_rate":1},{"cnt":[[344,1087],[1833,1087],[1833,1137],[344,1137]],"region":{"top_left_x":343,"top_left_y":1087,"width":1490,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb58f186e849486cbb7b4e2029f8e69b","type":"text","conversion_output":true,"text":"patients classified as having good hair preservation ranged from 41 to \\(97 \\%\\) (compared to","text_display":" patients classified as having good hair preservation ranged from 41 to \\(97 \\%\\) (compared to","confidence":1,"confidence_rate":1},{"cnt":[[344,1134],[1766,1134],[1766,1184],[344,1184]],"region":{"top_left_x":343,"top_left_y":1134,"width":1424,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36fdf232a0a942c1a4831d7708bff8b1","type":"text","conversion_output":true,"text":"\\(0-38 \\%\\) for controls). In the 11 non-randomized, controlled studies without statistical","text_display":" \\(0-38 \\%\\) for controls). In the 11 non-randomized, controlled studies without statistical","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[346,1182],[1717,1182],[1717,1233],[346,1233]],"region":{"top_left_x":345,"top_left_y":1181,"width":1372,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36fed03154c040c6abe448c4514a72ad","type":"text","conversion_output":true,"text":"analysis, an average of \\(67 \\%\\) of patients had good hair preservation. In the 36 non-","text_display":" analysis, an average of \\(67 \\%\\) of patients had good hair preservation. In the 36 non","confidence":1,"confidence_rate":1},{"cnt":[[346,1231],[1880,1231],[1880,1280],[346,1280]],"region":{"top_left_x":345,"top_left_y":1231,"width":1535,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c56cf21217a4fd89402849a030edabd","type":"text","conversion_output":true,"text":"controlled studies, positive effects of scalp cooling on hair preservation were seen in all but","text_display":"controlled studies, positive effects of scalp cooling on hair preservation were seen in all but","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[344,1328],[344,1277],[1678,1280],[1678,1331]],"region":{"top_left_x":343,"top_left_y":1277,"width":1336,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a17aa575683145668ad0587a9ddfbdc6","type":"text","conversion_output":true,"text":"one study. The median value of good hair preservation in this latter serious was","text_display":" one study. The median value of good hair preservation in this latter serious was","confidence":1,"confidence_rate":1},{"cnt":[[344,1328],[1876,1328],[1876,1377],[344,1377]],"region":{"top_left_x":343,"top_left_y":1327,"width":1533,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d58e2d6d0b6445c81922c68eb652ded","type":"text","conversion_output":true,"text":"approximately \\(80 \\%\\). Together, these studies are considered to constitute reasonable clinical","text_display":" approximately \\(80 \\%\\). Together, these studies are considered to constitute reasonable clinical","confidence":0.9990236759185791,"confidence_rate":0.9999902320377446},{"cnt":[[344,1375],[1751,1375],[1751,1424],[344,1424]],"region":{"top_left_x":343,"top_left_y":1375,"width":1408,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d86ce099f704e51b710c93fc304b718","type":"text","conversion_output":true,"text":"evidence that scalp cooling is effective in reducing chemotherapy-induced alopecia.","text_display":" evidence that scalp cooling is effective in reducing chemotherapy-induced alopecia.","confidence":1,"confidence_rate":1},{"cnt":[[344,1444],[1807,1444],[1807,1493],[344,1493]],"region":{"top_left_x":343,"top_left_y":1443,"width":1464,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f12d213d5249454f8b7f04b80bca4729","type":"text","conversion_output":true,"text":"Many of the studies provide additional detail about the various chemotherapy regimens","text_display":"\n\nMany of the studies provide additional detail about the various chemotherapy regimens","confidence":1,"confidence_rate":1},{"cnt":[[344,1491],[1854,1491],[1854,1540],[344,1540]],"region":{"top_left_x":343,"top_left_y":1491,"width":1512,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afef1524df1d48d083d7c46bcd5836f1","type":"text","conversion_output":true,"text":"and include outcome measures other than the severity of hair loss. In a Danish study of 62","text_display":" and include outcome measures other than the severity of hair loss. In a Danish study of 62","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[344,1540],[1764,1540],[1764,1588],[344,1588]],"region":{"top_left_x":343,"top_left_y":1540,"width":1421,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d72f1e3efe7421b91e55db63053a50a","type":"text","conversion_output":true,"text":"evaluable women, several outcomes were considered including: severity of hair loss,","text_display":" evaluable women, several outcomes were considered including: severity of hair loss,","confidence":1,"confidence_rate":1},{"cnt":[[344,1588],[1772,1588],[1772,1637],[344,1637]],"region":{"top_left_x":343,"top_left_y":1587,"width":1430,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2158c59e60f54200b8e31f412aa7c527","type":"text","conversion_output":true,"text":"burden of hair loss, burden of scalp cooling, wig use, hair regrowth, and body image.","text_display":" burden of hair loss, burden of scalp cooling, wig use, hair regrowth, and body image.","confidence":1,"confidence_rate":1},{"cnt":[[344,1635],[1837,1635],[1837,1687],[344,1687]],"region":{"top_left_x":343,"top_left_y":1634,"width":1494,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fd1dbaa16c347dd8b5510e6c291b5f4","type":"text","conversion_output":true,"text":"Drug regimens included Adriamycin/Cytoxan (AC), 5-FU/Epirubicin/Cytoxan (FEC), 5-","text_display":" Drug regimens included Adriamycin/Cytoxan (AC), 5-FU/Epirubicin/Cytoxan (FEC), 5","confidence":1,"confidence_rate":1},{"cnt":[[344,1684],[1854,1684],[1854,1734],[344,1734]],"region":{"top_left_x":343,"top_left_y":1684,"width":1512,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee9ffb64c7eb4070946f2552720e8b1c","type":"text","conversion_output":true,"text":"FU/Adriamycin/Cytoxan (FAC) and Taxotere/Adriamycin/Cytoxan (TAC). Scalp cooling","text_display":"FU/Adriamycin/Cytoxan (FAC) and Taxotere/Adriamycin/Cytoxan (TAC). Scalp cooling","confidence":1,"confidence_rate":1},{"cnt":[[344,1732],[1852,1732],[1852,1781],[344,1781]],"region":{"top_left_x":343,"top_left_y":1731,"width":1509,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e812a03c34145ef9baa9a3e0d843975","type":"text","conversion_output":true,"text":"was effective in preventing chemotherapy-induced hair loss in 32 of 62 evaluable patients","text_display":" was effective in preventing chemotherapy-induced hair loss in 32 of 62 evaluable patients","confidence":1,"confidence_rate":1},{"cnt":[[346,1779],[1837,1779],[1837,1828],[346,1828]],"region":{"top_left_x":345,"top_left_y":1778,"width":1492,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"532d2282b4e444c5a22ed8b92dd86c32","type":"text","conversion_output":true,"text":"(Mols 2009). In this study, patients did not perceive scalp cooling as burdensome. In this","text_display":" (Mols 2009). In this study, patients did not perceive scalp cooling as burdensome. In this","confidence":1,"confidence_rate":1},{"cnt":[[344,1826],[1858,1826],[1858,1876],[344,1876]],"region":{"top_left_x":343,"top_left_y":1826,"width":1516,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70c42ca0fbac4c9da43b8c3dc49b2ddd","type":"text","conversion_output":true,"text":"study and others, the TAC regimen is associated with poor hair preservation even with the","text_display":" study and others, the TAC regimen is associated with poor hair preservation even with the","confidence":1,"confidence_rate":1},{"cnt":[[344,1876],[1644,1876],[1644,1927],[344,1927]],"region":{"top_left_x":343,"top_left_y":1875,"width":1301,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddd2c8f17a014611b31c0f8ef3a33d29","type":"text","conversion_output":true,"text":"use of scalp cooling (likely related to concurrent taxane \\& anthracycline use).","text_display":" use of scalp cooling (likely related to concurrent taxane \\& anthracycline use).","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[344,1944],[1818,1944],[1818,1994],[344,1994]],"region":{"top_left_x":343,"top_left_y":1944,"width":1475,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0313bba7db740ddacf19a77b6711dfa","type":"text","conversion_output":true,"text":"The effect of alopecia and the effects of scalp cooling on well-being were looked at in a","text_display":"\nThe effect of alopecia and the effects of scalp cooling on well-being were looked at in a","confidence":1,"confidence_rate":1},{"cnt":[[344,1989],[1820,1989],[1820,2041],[344,2041]],"region":{"top_left_x":343,"top_left_y":1989,"width":1477,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13563ff42f2b46e7bc65522b8715e73d","type":"text","conversion_output":true,"text":"study by van den Hurk (Van den Hurk 2010). This was a prospective multi-center study","text_display":" study by van den Hurk (Van den Hurk 2010). This was a prospective multi-center study","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[344,2041],[1766,2041],[1766,2090],[344,2090]],"region":{"top_left_x":343,"top_left_y":2041,"width":1424,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"293e3d8cc1d4433491fe020a95247914","type":"text","conversion_output":true,"text":"performed in 13 hospitals. The Paxman system for scalp cooling was utilized. Breast","text_display":" performed in 13 hospitals. The Paxman system for scalp cooling was utilized. Breast","confidence":1,"confidence_rate":1},{"cnt":[[344,2088],[1876,2088],[1876,2138],[344,2138]],"region":{"top_left_x":343,"top_left_y":2088,"width":1533,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee5eda49ea56449bbf9b6efbc4f0e527","type":"text","conversion_output":true,"text":"cancer patients receiving chemotherapy combinations including anthracyclines and taxanes","text_display":" cancer patients receiving chemotherapy combinations including anthracyclines and taxanes","confidence":1,"confidence_rate":1},{"cnt":[[344,2136],[1846,2136],[1846,2185],[344,2185]],"region":{"top_left_x":343,"top_left_y":2135,"width":1503,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee9360dfbffb499ab816712f0809324a","type":"text","conversion_output":true,"text":"were included. This study looked at both the severity of alopecia and at several quality of","text_display":" were included. This study looked at both the severity of alopecia and at several quality of","confidence":1,"confidence_rate":1},{"cnt":[[344,2183],[1820,2183],[1820,2232],[344,2232]],"region":{"top_left_x":343,"top_left_y":2182,"width":1477,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e433b8dea6b45d19191ef4595f934d9","type":"text","conversion_output":true,"text":"life measures to assess well-being of patients. Scalp cooling was effective in \\(52 \\%\\) of the","text_display":" life measures to assess well-being of patients. Scalp cooling was effective in \\(52 \\%\\) of the","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[344,2230],[1818,2230],[1818,2282],[344,2282]],"region":{"top_left_x":343,"top_left_y":2230,"width":1475,"height":52},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d981b640d12648238617140194316ecd","type":"text","conversion_output":true,"text":"cases. There was a trend toward higher well-being and a better body image in the scalp-","text_display":" cases. There was a trend toward higher well-being and a better body image in the scalp","confidence":1,"confidence_rate":1},{"cnt":[[344,2279],[606,2279],[606,2331],[344,2331]],"region":{"top_left_x":343,"top_left_y":2279,"width":263,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7809538cc6564bbf85f7706fbf105c41","type":"text","conversion_output":true,"text":"cooled patients","text_display":"cooled patients","confidence":1,"confidence_rate":1},{"cnt":[[346,2348],[1721,2348],[1721,2396],[346,2396]],"region":{"top_left_x":345,"top_left_y":2348,"width":1376,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2d1ea7af4d140f5a1d28e95f312d389","type":"text","conversion_output":true,"text":"Several additional studies have looked specifically at the Orbis Paxman Hair Loss","text_display":"\nSeveral additional studies have looked specifically at the Orbis Paxman Hair Loss","confidence":1,"confidence_rate":1},{"cnt":[[346,2396],[1880,2396],[1880,2447],[346,2447]],"region":{"top_left_x":345,"top_left_y":2395,"width":1535,"height":53},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae33f35d9287484db2f88072fa4cde8c","type":"text","conversion_output":true,"text":"Prevention System. One of the first was the study by Massey that looked at scalp cooling at","text_display":" Prevention System. One of the first was the study by Massey that looked at scalp cooling at","confidence":1,"confidence_rate":1},{"cnt":[[346,2445],[1833,2445],[1833,2494],[346,2494]],"region":{"top_left_x":345,"top_left_y":2444,"width":1488,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecf4879c92934d40bbaf75ed7c12028d","type":"text","conversion_output":true,"text":"8 centers in United Kingdom with data collection from 1997 to 2000 (Massey 2004). All","text_display":" 8 centers in United Kingdom with data collection from 1997 to 2000 (Massey 2004). All","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":53},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"408416d0be694b718276f33999ee7873","type":"page_info","conversion_output":false,"text":"12","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-13","page":13,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ada6fea777f849ebb7f90c24907a2d9d","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b6a01c2fb184eb59b6fa0682823b00a","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[344,251],[1848,251],[1848,303],[344,303]],"region":{"top_left_x":343,"top_left_y":251,"width":1505,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"771360869a27493c98c0b17fa28d9f5a","type":"text","conversion_output":true,"text":"patients were women with breast cancer being treated in the adjuvant or palliative setting.","text_display":"\npatients were women with breast cancer being treated in the adjuvant or palliative setting.","confidence":1,"confidence_rate":1},{"cnt":[[344,301],[1687,301],[1687,350],[344,350]],"region":{"top_left_x":343,"top_left_y":300,"width":1344,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"311499ac5c3f4657bd5dfa36d9a835b4","type":"text","conversion_output":true,"text":"Twelve different chemotherapy regimens were utilized. The procedure included","text_display":" Twelve different chemotherapy regimens were utilized. The procedure included","confidence":1,"confidence_rate":1},{"cnt":[[344,348],[1871,348],[1871,397],[344,397]],"region":{"top_left_x":343,"top_left_y":348,"width":1529,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"419efe221f254c0fb53dbd51bab55ecf","type":"text","conversion_output":true,"text":"application of small amount of conditioner to dampened hair, to allow for closer contact of","text_display":" application of small amount of conditioner to dampened hair, to allow for closer contact of","confidence":1,"confidence_rate":1},{"cnt":[[344,397],[1811,397],[1811,445],[344,445]],"region":{"top_left_x":343,"top_left_y":397,"width":1469,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1572e0682fe74ee6ab034ca8e0a12193","type":"text","conversion_output":true,"text":"the PSC with the scalp. A pre-cooling time of 15-20 minutes was recommended, with a","text_display":" the PSC with the scalp. A pre-cooling time of 15-20 minutes was recommended, with a","confidence":0.98291015625,"confidence_rate":0.9998041378139619},{"cnt":[[344,443],[1841,443],[1841,494],[344,494]],"region":{"top_left_x":343,"top_left_y":442,"width":1499,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5eaf22bb6ad4781b5d5d380cdb3127d","type":"text","conversion_output":true,"text":"post infusion cooling time of 2 hours for most regimens. A variation of the WHO criteria","text_display":" post infusion cooling time of 2 hours for most regimens. A variation of the WHO criteria","confidence":1,"confidence_rate":1},{"cnt":[[344,542],[344,489],[1848,492],[1848,545]],"region":{"top_left_x":343,"top_left_y":489,"width":1505,"height":56},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4db15b242ee4dbaae720a3007ef33ee","type":"text","conversion_output":true,"text":"for alopecia was utilized. Nurses graded the alopecia and patients were asked to complete","text_display":" for alopecia was utilized. Nurses graded the alopecia and patients were asked to complete","confidence":1,"confidence_rate":1},{"cnt":[[344,539],[1807,539],[1807,591],[344,591]],"region":{"top_left_x":343,"top_left_y":539,"width":1464,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea51bf73606a4e9e818540150734a145","type":"text","conversion_output":true,"text":"report forms on attitude toward the process and side effects. A total of 94 patients were","text_display":" report forms on attitude toward the process and side effects. A total of 94 patients were","confidence":1,"confidence_rate":1},{"cnt":[[344,589],[1794,589],[1794,638],[344,638]],"region":{"top_left_x":343,"top_left_y":588,"width":1451,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15aef7fabebd40d9aae4186417ce4a0b","type":"text","conversion_output":true,"text":"included in the study, with 66\\% of patients receiving FEC. Of these patients, 89\\% had","text_display":" included in the study, with 66\\% of patients receiving FEC. Of these patients, 89\\% had","confidence":0.5007076263427734,"confidence_rate":0.992343539740358},{"cnt":[[346,636],[1068,636],[1068,685],[346,685]],"region":{"top_left_x":345,"top_left_y":635,"width":723,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"384529fa855d4a928c55cf223dd809bb","type":"text","conversion_output":true,"text":"grade 0 alopecia and did not require a wig.","text_display":" grade 0 alopecia and did not require a wig.","confidence":1,"confidence_rate":1},{"cnt":[[346,705],[1848,705],[1848,754],[346,754]],"region":{"top_left_x":345,"top_left_y":704,"width":1503,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cab8e2b3f1e1438aa8bda22384df9269","type":"text","conversion_output":true,"text":"In summary, there are many studies and reviews that have looked at scalp cooling. Many","text_display":"\n\nIn summary, there are many studies and reviews that have looked at scalp cooling. Many","confidence":1,"confidence_rate":1},{"cnt":[[344,752],[1790,752],[1790,801],[344,801]],"region":{"top_left_x":343,"top_left_y":751,"width":1447,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"770407aa66ea4ba7a586e12372026b92","type":"text","conversion_output":true,"text":"of these studies were small and not well designed. It is also difficult to compare these","text_display":" of these studies were small and not well designed. It is also difficult to compare these","confidence":1,"confidence_rate":1},{"cnt":[[344,799],[1818,799],[1818,849],[344,849]],"region":{"top_left_x":343,"top_left_y":799,"width":1475,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6c512e0f7194bb4a457bbf16a6600db","type":"text","conversion_output":true,"text":"studies because of differences in patient characteristics, chemotherapy agents, length of","text_display":" studies because of differences in patient characteristics, chemotherapy agents, length of","confidence":1,"confidence_rate":1},{"cnt":[[344,846],[1824,846],[1824,898],[344,898]],"region":{"top_left_x":343,"top_left_y":846,"width":1482,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8470b564507a41749b2fe4db6828a322","type":"text","conversion_output":true,"text":"cooling, and hair loss assessments. Most of these studies have been done in Europe and","text_display":" cooling, and hair loss assessments. Most of these studies have been done in Europe and","confidence":1,"confidence_rate":1},{"cnt":[[344,896],[1865,894],[1865,947],[344,950]],"region":{"top_left_x":343,"top_left_y":893,"width":1522,"height":57},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f519c6b171e4bb49a978c873e451ec1","type":"text","conversion_output":true,"text":"more recently Asia. Success rates are variable, but scalp cooling appears to be effective in","text_display":" more recently Asia. Success rates are variable, but scalp cooling appears to be effective in","confidence":1,"confidence_rate":1},{"cnt":[[344,941],[1807,941],[1807,993],[344,993]],"region":{"top_left_x":343,"top_left_y":941,"width":1464,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d41b24cd5804be1b6b4ac2e97663a40","type":"text","conversion_output":true,"text":"preventing chemotherapy-induce alopecia especially in more recent studies. The Orbis","text_display":" preventing chemotherapy-induce alopecia especially in more recent studies. The Orbis","confidence":1,"confidence_rate":1},{"cnt":[[344,993],[1807,993],[1807,1042],[344,1042]],"region":{"top_left_x":343,"top_left_y":992,"width":1464,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da2ecfe8e22f492ea5d1b4391e80649e","type":"text","conversion_output":true,"text":"Paxman Hair Loss Prevention System is widely used to prevent chemotherapy-induced","text_display":" Paxman Hair Loss Prevention System is widely used to prevent chemotherapy-induced","confidence":1,"confidence_rate":1},{"cnt":[[344,1040],[1867,1040],[1867,1089],[344,1089]],"region":{"top_left_x":343,"top_left_y":1039,"width":1524,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1de810e21ed4ffea98a8c8d02d2a1ab","type":"text","conversion_output":true,"text":"alopecia in Europe, Australia, and Asia. In the United States scalp cooling is rarely used as","text_display":" alopecia in Europe, Australia, and Asia. In the United States scalp cooling is rarely used as","confidence":1,"confidence_rate":1},{"cnt":[[344,1087],[1296,1087],[1296,1137],[344,1137]],"region":{"top_left_x":343,"top_left_y":1087,"width":953,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e55fdad49c6748e49a897261cb858aae","type":"text","conversion_output":true,"text":"it is not approved by the Food and Drug Administration.","text_display":" it is not approved by the Food and Drug Administration.","confidence":1,"confidence_rate":1},{"cnt":[[348,1175],[943,1175],[943,1240],[348,1240]],"region":{"top_left_x":348,"top_left_y":1175,"width":596,"height":65},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04ad44dead004fd6954ecf2e8d117d5b","type":"section_header","conversion_output":false,"children_ids":["b014725bd9b54958853b8fb40431a548"],"text":"","text_display":""},{"cnt":[[354,1182],[939,1182],[939,1235],[354,1235]],"region":{"top_left_x":354,"top_left_y":1181,"width":585,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b014725bd9b54958853b8fb40431a548","type":"text","conversion_output":true,"parent_id":"04ad44dead004fd6954ecf2e8d117d5b","text":"C. 4 Scalp Metastases Concern","text_display":"\n\n\\section*{C. 4 Scalp Metastases Concern}","confidence":0.9990234375,"confidence_rate":0.9999735938716796},{"cnt":[[344,1250],[1798,1250],[1798,1302],[344,1302]],"region":{"top_left_x":343,"top_left_y":1250,"width":1456,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91a58fc2b2c043c094a962034cafc9d4","type":"text","conversion_output":true,"text":"As scalp cooling acts by reducing the effect of chemotherapy in the scalp, a theoretical","text_display":"\n\nAs scalp cooling acts by reducing the effect of chemotherapy in the scalp, a theoretical","confidence":1,"confidence_rate":1},{"cnt":[[344,1300],[1863,1300],[1863,1349],[344,1349]],"region":{"top_left_x":343,"top_left_y":1299,"width":1520,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16bdc62ae6be418e8270bee7a23ad21c","type":"text","conversion_output":true,"text":"increased risk of scalp metastases is often discussed. Since breast cancers may metastasize","text_display":" increased risk of scalp metastases is often discussed. Since breast cancers may metastasize","confidence":1,"confidence_rate":1},{"cnt":[[344,1349],[1863,1349],[1863,1399],[344,1399]],"region":{"top_left_x":343,"top_left_y":1349,"width":1520,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9af6d88104f54655a02e0c308bf418e1","type":"text","conversion_output":true,"text":"to the scalp, the discussion most often concerns these patients. Published data demonstrate","text_display":" to the scalp, the discussion most often concerns these patients. Published data demonstrate","confidence":1,"confidence_rate":1},{"cnt":[[344,1396],[1742,1396],[1742,1446],[344,1446]],"region":{"top_left_x":343,"top_left_y":1396,"width":1400,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cb353029de44d2695d612ebc36043fc","type":"text","conversion_output":true,"text":"that the incidence of scalp metastasis following adjuvant therapy in breast cancer is","text_display":" that the incidence of scalp metastasis following adjuvant therapy in breast cancer is","confidence":1,"confidence_rate":1},{"cnt":[[344,1444],[1742,1444],[1742,1493],[344,1493]],"region":{"top_left_x":343,"top_left_y":1443,"width":1400,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5cfa3aa83b24c009d3641002677688b","type":"text","conversion_output":true,"text":"inherently low and it is exceedingly rare to have scalp metastases as the first site of","text_display":" inherently low and it is exceedingly rare to have scalp metastases as the first site of","confidence":1,"confidence_rate":1},{"cnt":[[344,1491],[1734,1491],[1734,1540],[344,1540]],"region":{"top_left_x":343,"top_left_y":1491,"width":1391,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7844777d1de4c4c8ae2bd9ffc6a9932","type":"text","conversion_output":true,"text":"metastases as they nearly always occur late in the course of the disease when other","text_display":" metastases as they nearly always occur late in the course of the disease when other","confidence":1,"confidence_rate":1},{"cnt":[[344,1538],[1777,1538],[1777,1590],[344,1590]],"region":{"top_left_x":343,"top_left_y":1538,"width":1434,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c90d1f99115849ba99bf8556c098a198","type":"text","conversion_output":true,"text":"metastases are already present. Thus, increasing a woman's chance of dying of breast","text_display":" metastases are already present. Thus, increasing a woman's chance of dying of breast","confidence":1,"confidence_rate":1},{"cnt":[[344,1588],[1833,1588],[1833,1639],[344,1639]],"region":{"top_left_x":343,"top_left_y":1587,"width":1490,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e94895b5f3ad4abe833b5140f86969b5","type":"text","conversion_output":true,"text":"cancer because she underwent scalp cooling at the time of adjuvant chemotherapy seems","text_display":" cancer because she underwent scalp cooling at the time of adjuvant chemotherapy seems","confidence":1,"confidence_rate":1},{"cnt":[[344,1637],[754,1637],[754,1687],[344,1687]],"region":{"top_left_x":343,"top_left_y":1637,"width":412,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00a85feb13644fe991e00c0656358c17","type":"text","conversion_output":true,"text":"remote if possible at all.","text_display":" remote if possible at all.","confidence":1,"confidence_rate":1},{"cnt":[[344,1706],[1852,1706],[1852,1755],[344,1755]],"region":{"top_left_x":343,"top_left_y":1705,"width":1509,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15fbcfa4b0b84d00a60c10bcd572efdb","type":"text","conversion_output":true,"text":"Rugo and Melin analyzed all the literature to date in a correspondence (Rugo 2010). This","text_display":"\n\nRugo and Melin analyzed all the literature to date in a correspondence (Rugo 2010). This","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[344,1751],[1867,1751],[1867,1800],[344,1800]],"region":{"top_left_x":343,"top_left_y":1750,"width":1524,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa4d3a1241e542edbd6348fd64690619","type":"text","conversion_output":true,"text":"included a study by Browstein and Helwig where metastatic sites were identified in a 1972","text_display":" included a study by Browstein and Helwig where metastatic sites were identified in a 1972","confidence":1,"confidence_rate":1},{"cnt":[[344,1800],[1781,1800],[1781,1850],[344,1850]],"region":{"top_left_x":343,"top_left_y":1800,"width":1439,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ae34e85dad643a88d5c2fdb760d1136","type":"text","conversion_output":true,"text":"study of 167 women with breast cancer and cutaneous metastasis who did not receive","text_display":" study of 167 women with breast cancer and cutaneous metastasis who did not receive","confidence":1,"confidence_rate":1},{"cnt":[[344,1848],[1738,1848],[1738,1897],[344,1897]],"region":{"top_left_x":343,"top_left_y":1847,"width":1396,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7070c8883629440d847419e1f1a02156","type":"text","conversion_output":true,"text":"chemotherapy. The incidence of scalp involvement in these women with cutaneous","text_display":" chemotherapy. The incidence of scalp involvement in these women with cutaneous","confidence":1,"confidence_rate":1},{"cnt":[[344,1895],[1850,1895],[1850,1944],[344,1944]],"region":{"top_left_x":343,"top_left_y":1894,"width":1507,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"379d2a3c467a479e8540bed1ad6bd2e4","type":"text","conversion_output":true,"text":"metastasis was only \\(3 \\%\\). The authors emphasized that the scalp metastasis in women with","text_display":" metastasis was only \\(3 \\%\\). The authors emphasized that the scalp metastasis in women with","confidence":1,"confidence_rate":1},{"cnt":[[344,1942],[1852,1942],[1852,1996],[344,1996]],"region":{"top_left_x":343,"top_left_y":1942,"width":1509,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4870678b76da4eec95687558125371c1","type":"text","conversion_output":true,"text":"breast cancer usually occurred late in the disease. Furthermore Rugo and Melin, looked at","text_display":" breast cancer usually occurred late in the disease. Furthermore Rugo and Melin, looked at","confidence":1,"confidence_rate":1},{"cnt":[[344,1989],[1781,1989],[1781,2041],[344,2041]],"region":{"top_left_x":343,"top_left_y":1989,"width":1439,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e05414497a3c48cba0ec2491b5105b51","type":"text","conversion_output":true,"text":"three studies from 1976 to 2009, involving a total of 2,697 breast cancer patients who","text_display":" three studies from 1976 to 2009, involving a total of 2,697 breast cancer patients who","confidence":0.66650390625,"confidence_rate":0.9956932446299664},{"cnt":[[344,2041],[1781,2041],[1781,2090],[344,2090]],"region":{"top_left_x":343,"top_left_y":2041,"width":1439,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f9c249826a043fa9594f6bdb908e470","type":"text","conversion_output":true,"text":"received chemotherapy without scalp cooling and who were followed up for around 5","text_display":" received chemotherapy without scalp cooling and who were followed up for around 5","confidence":1,"confidence_rate":1},{"cnt":[[344,2088],[1867,2088],[1867,2138],[344,2138]],"region":{"top_left_x":343,"top_left_y":2088,"width":1524,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d6356bf81784567b4b971a59e347015","type":"text","conversion_output":true,"text":"years; the incidence of scalp metastases ranged from \\(1.2 \\%\\) to \\(2.5 \\%\\) (while the incidence of","text_display":" years; the incidence of scalp metastases ranged from \\(1.2 \\%\\) to \\(2.5 \\%\\) (while the incidence of","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[344,2136],[1749,2136],[1749,2185],[344,2185]],"region":{"top_left_x":343,"top_left_y":2135,"width":1406,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfe79da358d1475f93223e6871661350","type":"text","conversion_output":true,"text":"all skin metastases ranged from \\(24 \\%\\) to \\(30 \\%\\) ). When breast cancer is metastatic and","text_display":" all skin metastases ranged from \\(24 \\%\\) to \\(30 \\%\\) ). When breast cancer is metastatic and","confidence":0.9912149906158447,"confidence_rate":0.9999051246614107},{"cnt":[[344,2183],[1717,2183],[1717,2232],[344,2232]],"region":{"top_left_x":343,"top_left_y":2182,"width":1374,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ec79603f90248ea8c0077bfa4bfc26b","type":"text","conversion_output":true,"text":"involves the skin or scalp, the breast cancer is usually widespread and it would be","text_display":" involves the skin or scalp, the breast cancer is usually widespread and it would be","confidence":1,"confidence_rate":1},{"cnt":[[344,2230],[1815,2230],[1815,2282],[344,2282]],"region":{"top_left_x":343,"top_left_y":2230,"width":1473,"height":52},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02419837b11042eab8f0d8645c9d49f7","type":"text","conversion_output":true,"text":"exceedingly rare to have breast cancer recur with the scalp as the only site of metastatic","text_display":" exceedingly rare to have breast cancer recur with the scalp as the only site of metastatic","confidence":1,"confidence_rate":1},{"cnt":[[344,2277],[1841,2277],[1841,2331],[344,2331]],"region":{"top_left_x":343,"top_left_y":2277,"width":1499,"height":55},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b1955a5a9a345b0b61210db863e353b","type":"text","conversion_output":true,"text":"disease. It is also exceedingly rare for scalp metastases to be the first site of recurrence in","text_display":" disease. It is also exceedingly rare for scalp metastases to be the first site of recurrence in","confidence":1,"confidence_rate":1},{"cnt":[[344,2329],[724,2329],[724,2378],[344,2378]],"region":{"top_left_x":343,"top_left_y":2328,"width":382,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db2762e3f04749daa5a95a9cf8ed737d","type":"text","conversion_output":true,"text":"breast cancer patients.","text_display":" breast cancer patients.","confidence":1,"confidence_rate":1},{"cnt":[[346,2396],[1785,2396],[1785,2447],[346,2447]],"region":{"top_left_x":345,"top_left_y":2395,"width":1441,"height":53},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1323a0ef8b434f16b42bd617eb72c1e4","type":"text","conversion_output":true,"text":"In consideration of scalp metastases as the first site of recurrence of cancer, Rugo and","text_display":"\nIn consideration of scalp metastases as the first site of recurrence of cancer, Rugo and","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[344,2443],[1790,2443],[1790,2494],[344,2494]],"region":{"top_left_x":343,"top_left_y":2442,"width":1447,"height":53},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ffe55d9041045708fafe75b5ca725a0","type":"text","conversion_output":true,"text":"Melin looked at reference data from the National Surgical Adjuvant Breast and Bowel","text_display":" Melin looked at reference data from the National Surgical Adjuvant Breast and Bowel","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":53},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95dc1d461b1b493fa117832c2dc3351b","type":"page_info","conversion_output":false,"text":"13","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-14","page":14,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ddf84d7a1b64c52b4a248b9caae84ea","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"900fdc3c59ea46c183404008cea497d7","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[344,251],[1867,251],[1867,303],[344,303]],"region":{"top_left_x":343,"top_left_y":251,"width":1524,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dc507f62c124026bf5be54431135e8e","type":"text","conversion_output":true,"text":"Project (NSABP), involving 7,800 women with breast cancer treated with surgery alone or","text_display":"\n\nProject (NSABP), involving 7,800 women with breast cancer treated with surgery alone or","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[344,301],[1762,301],[1762,350],[344,350]],"region":{"top_left_x":343,"top_left_y":300,"width":1419,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b17241c616ab44c5801803cc8d63bd1e","type":"text","conversion_output":true,"text":"combined with chemotherapy (Rugo 2010). Of these 7,800 women, only \\(2(0.025 \\%)\\)","text_display":" combined with chemotherapy (Rugo 2010). Of these 7,800 women, only \\(2(0.025 \\%)\\)","confidence":0.5109691619873047,"confidence_rate":0.9919429223435353},{"cnt":[[344,348],[1798,348],[1798,397],[344,397]],"region":{"top_left_x":343,"top_left_y":348,"width":1456,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d688749fc474809b8b9e62dbc6ad47a","type":"text","conversion_output":true,"text":"experienced scalp metastasis as their first site of recurrence. Both of these patients had","text_display":" experienced scalp metastasis as their first site of recurrence. Both of these patients had","confidence":1,"confidence_rate":1},{"cnt":[[344,397],[1764,397],[1764,447],[344,447]],"region":{"top_left_x":343,"top_left_y":397,"width":1421,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58664e890ca74dd094883b78e922cb93","type":"text","conversion_output":true,"text":"positive lymph nodes and one of them had received adjuvant chemotherapy. It is not","text_display":" positive lymph nodes and one of them had received adjuvant chemotherapy. It is not","confidence":1,"confidence_rate":1},{"cnt":[[344,443],[1850,443],[1850,494],[344,494]],"region":{"top_left_x":343,"top_left_y":442,"width":1507,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3aae83d5c8b7412280a495bad787fd6b","type":"text","conversion_output":true,"text":"mentioned in the correspondence how many of these women had skin metastases or scalp","text_display":" mentioned in the correspondence how many of these women had skin metastases or scalp","confidence":1,"confidence_rate":1},{"cnt":[[344,490],[1790,490],[1790,544],[344,544]],"region":{"top_left_x":343,"top_left_y":489,"width":1447,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1826d7090c164ee3bab45ff8c2fc54d2","type":"text","conversion_output":true,"text":"metastases. Rugo \\& Melin's expert opinion was \"that scalp cooling can and should be","text_display":" metastases. Rugo \\& Melin's expert opinion was \"that scalp cooling can and should be","confidence":1,"confidence_rate":1},{"cnt":[[344,539],[1863,539],[1863,591],[344,591]],"region":{"top_left_x":343,"top_left_y":539,"width":1520,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c36afe79c63b4820a6189ac7c9043323","type":"text","conversion_output":true,"text":"offered to breast cancer patients who will be treated with adjuvant chemotherapy, and also","text_display":" offered to breast cancer patients who will be treated with adjuvant chemotherapy, and also","confidence":1,"confidence_rate":1},{"cnt":[[344,589],[1734,589],[1734,638],[344,638]],"region":{"top_left_x":343,"top_left_y":588,"width":1391,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9db9ce031fa547a8b45a3070f8261110","type":"text","conversion_output":true,"text":"those who are offered palliative chemotherapy associated with a significant risk of","text_display":" those who are offered palliative chemotherapy associated with a significant risk of","confidence":1,"confidence_rate":1},{"cnt":[[344,636],[1809,636],[1809,685],[344,685]],"region":{"top_left_x":343,"top_left_y":635,"width":1466,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe4a230954c341e291ec37186686c19b","type":"text","conversion_output":true,"text":"alopecia. The risks involved appear to be extremely small and the potential gain for the","text_display":" alopecia. The risks involved appear to be extremely small and the potential gain for the","confidence":1,"confidence_rate":1},{"cnt":[[344,683],[1837,683],[1837,733],[344,733]],"region":{"top_left_x":343,"top_left_y":683,"width":1494,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8b377532acb40cdbcab48708f867114","type":"text","conversion_output":true,"text":"large number of women receiving adjuvant chemotherapy for breast cancer in the United","text_display":" large number of women receiving adjuvant chemotherapy for breast cancer in the United","confidence":1,"confidence_rate":1},{"cnt":[[344,730],[711,730],[711,776],[344,776]],"region":{"top_left_x":343,"top_left_y":730,"width":369,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c4b7e05a38b4f5fb4bf61d0e8f13ce5","type":"text","conversion_output":true,"text":"States is substantial.\"","text_display":" States is substantial.\"","confidence":0.99951171875,"confidence_rate":0.9999825572771935},{"cnt":[[344,799],[1790,799],[1790,849],[344,849]],"region":{"top_left_x":343,"top_left_y":799,"width":1447,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9b61594694849ecbc5d82060bc51215","type":"text","conversion_output":true,"text":"A number of other studies investigating the incidence of scalp skin metastases, and its","text_display":"\n\nA number of other studies investigating the incidence of scalp skin metastases, and its","confidence":0.9990236759185791,"confidence_rate":0.9999893826542317},{"cnt":[[344,846],[1803,846],[1803,898],[344,898]],"region":{"top_left_x":343,"top_left_y":846,"width":1460,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"044e3778d57f4cab98bd349cda1c90f5","type":"text","conversion_output":true,"text":"relationship to scalp cooling, have been published in the literature. In a review of scalp","text_display":" relationship to scalp cooling, have been published in the literature. In a review of scalp","confidence":1,"confidence_rate":1},{"cnt":[[344,896],[1740,896],[1740,947],[344,947]],"region":{"top_left_x":343,"top_left_y":895,"width":1398,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"181edd1c5ea741d2bb8866913b2f7749","type":"text","conversion_output":true,"text":"cooling by Grevelman and Breed that included 56 studies and approximately 2,500","text_display":" cooling by Grevelman and Breed that included 56 studies and approximately 2,500","confidence":0.89306640625,"confidence_rate":0.9987009096325217},{"cnt":[[344,941],[1861,941],[1861,995],[344,995]],"region":{"top_left_x":343,"top_left_y":941,"width":1518,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e33115396ba04817ac2535a30c760e3a","type":"text","conversion_output":true,"text":"patients, scalp metastasis were reported in 9 patients ( \\(0.36 \\%\\) ) (Grevelman 2005). In a total","text_display":" patients, scalp metastasis were reported in 9 patients ( \\(0.36 \\%\\) ) (Grevelman 2005). In a total","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[344,993],[1751,993],[1751,1042],[344,1042]],"region":{"top_left_x":343,"top_left_y":992,"width":1408,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcdc4dc9e7f9452ab392f61c80d80a79","type":"text","conversion_output":true,"text":"of 24 of the 56 studies reviewed, specific attention was paid to the risk of scalp skin","text_display":" of 24 of the 56 studies reviewed, specific attention was paid to the risk of scalp skin","confidence":1,"confidence_rate":1},{"cnt":[[344,1040],[1869,1040],[1869,1089],[344,1089]],"region":{"top_left_x":343,"top_left_y":1039,"width":1527,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a62426474fa4578bfcd6ec6a2ef2bf5","type":"text","conversion_output":true,"text":"metastases following the use of scalp cooling. It was reported that no scalp skin metastases","text_display":" metastases following the use of scalp cooling. It was reported that no scalp skin metastases","confidence":1,"confidence_rate":1},{"cnt":[[344,1087],[1865,1087],[1865,1137],[344,1137]],"region":{"top_left_x":343,"top_left_y":1087,"width":1522,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4a0775fa4fc420491c97203105404e9","type":"text","conversion_output":true,"text":"were found in 16 of these studies. The follow-up time of the studies included in the review","text_display":" were found in 16 of these studies. The follow-up time of the studies included in the review","confidence":1,"confidence_rate":1},{"cnt":[[344,1134],[952,1134],[952,1179],[344,1179]],"region":{"top_left_x":343,"top_left_y":1134,"width":609,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0941fab89a1747f1bb436344f45da9d2","type":"text","conversion_output":true,"text":"varied from 2 months to 63 months.","text_display":" varied from 2 months to 63 months.","confidence":1,"confidence_rate":1},{"cnt":[[344,1203],[1841,1203],[1841,1253],[344,1253]],"region":{"top_left_x":343,"top_left_y":1203,"width":1499,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03c79ff5a9474b38a7c599aece87e587","type":"text","conversion_output":true,"text":"In addition to the review by Grevelman and Breed, a number of more recent studies have","text_display":"\n\nIn addition to the review by Grevelman and Breed, a number of more recent studies have","confidence":1,"confidence_rate":1},{"cnt":[[344,1250],[1783,1250],[1783,1302],[344,1302]],"region":{"top_left_x":343,"top_left_y":1250,"width":1441,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7847d1fb433427ca7c9fab3499d0a44","type":"text","conversion_output":true,"text":"investigated the incidence of scalp metastases following scalp cooling of women with","text_display":" investigated the incidence of scalp metastases following scalp cooling of women with","confidence":1,"confidence_rate":1},{"cnt":[[344,1298],[1850,1298],[1850,1351],[344,1351]],"region":{"top_left_x":343,"top_left_y":1297,"width":1507,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07da5fa3e6764dd88d8e295a40e0a955","type":"text","conversion_output":true,"text":"breast cancer receiving chemotherapy. In 2006, Christodoulu et al reported on a series of","text_display":" breast cancer receiving chemotherapy. In 2006, Christodoulu et al reported on a series of","confidence":0.9965848922729492,"confidence_rate":0.9999636075503244},{"cnt":[[344,1347],[1820,1347],[1820,1399],[344,1399]],"region":{"top_left_x":343,"top_left_y":1347,"width":1477,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9e88dc9b6684b1291cbd9daa24e4a8d","type":"text","conversion_output":true,"text":"227 breast cancer patients who underwent scalp cooling with a cold cap while receiving","text_display":" 227 breast cancer patients who underwent scalp cooling with a cold cap while receiving","confidence":0.89306640625,"confidence_rate":0.9987441854429089},{"cnt":[[344,1396],[1863,1396],[1863,1446],[344,1446]],"region":{"top_left_x":343,"top_left_y":1396,"width":1520,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a5f972b9d7b4c929cdc5248de6ef1f5","type":"text","conversion_output":true,"text":"chemotherapy (Christodoulou 2006). Two of the breast cancer patients ( \\(0.88 \\%\\) ) developed","text_display":" chemotherapy (Christodoulou 2006). Two of the breast cancer patients ( \\(0.88 \\%\\) ) developed","confidence":1,"confidence_rate":1},{"cnt":[[344,1444],[1798,1444],[1798,1493],[344,1493]],"region":{"top_left_x":343,"top_left_y":1443,"width":1456,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a95055d91549908b55eb057e507aef","type":"text","conversion_output":true,"text":"scalp metastases. Both patients had advanced cancer with multiple sites of metastases.","text_display":" scalp metastases. Both patients had advanced cancer with multiple sites of metastases.","confidence":1,"confidence_rate":1},{"cnt":[[344,1491],[1794,1491],[1794,1540],[344,1540]],"region":{"top_left_x":343,"top_left_y":1491,"width":1451,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e025b9d866ef493f800ecbedec159267","type":"text","conversion_output":true,"text":"The follow-up period for this study was not specified. The authors concluded that \"the","text_display":" The follow-up period for this study was not specified. The authors concluded that \"the","confidence":1,"confidence_rate":1},{"cnt":[[344,1538],[1876,1538],[1876,1590],[344,1590]],"region":{"top_left_x":343,"top_left_y":1538,"width":1533,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbb82a78ee424665a31ad3f1379284f3","type":"text","conversion_output":true,"text":"incidence of scalp metastases in patients using scalp cooling methods during chemotherapy","text_display":" incidence of scalp metastases in patients using scalp cooling methods during chemotherapy","confidence":1,"confidence_rate":1},{"cnt":[[344,1588],[1390,1588],[1390,1635],[344,1635]],"region":{"top_left_x":343,"top_left_y":1587,"width":1048,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fcceb9254ca474a89d154e219d996c7","type":"text","conversion_output":true,"text":"is low and it does not seem to influence the clinical outcome.\"","text_display":" is low and it does not seem to influence the clinical outcome.\"","confidence":1,"confidence_rate":1},{"cnt":[[344,1656],[1790,1656],[1790,1708],[344,1708]],"region":{"top_left_x":343,"top_left_y":1656,"width":1447,"height":53},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a11339a73ee8474d82273236602f8d53","type":"text","conversion_output":true,"text":"In a prospective multicenter study by Spaeth and colleagues, 911 cancer patients were","text_display":"\n\nIn a prospective multicenter study by Spaeth and colleagues, 911 cancer patients were","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[344,1706],[1841,1706],[1841,1755],[344,1755]],"region":{"top_left_x":343,"top_left_y":1705,"width":1499,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94fcb650e3e548179631a14607a32e2c","type":"text","conversion_output":true,"text":"included from 2002 to 2006 (Spaeth 2008). 876 of these patients were women, most with","text_display":" included from 2002 to 2006 (Spaeth 2008). 876 of these patients were women, most with","confidence":1,"confidence_rate":1},{"cnt":[[344,1749],[1820,1749],[1820,1803],[344,1803]],"region":{"top_left_x":343,"top_left_y":1748,"width":1477,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2336d40790444cce9bf8fdf601620137","type":"text","conversion_output":true,"text":"localized or advanced breast cancer, whom were treated with adjuvant chemotherapy or","text_display":" localized or advanced breast cancer, whom were treated with adjuvant chemotherapy or","confidence":1,"confidence_rate":1},{"cnt":[[344,1800],[1818,1800],[1818,1850],[344,1850]],"region":{"top_left_x":343,"top_left_y":1800,"width":1475,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f428c469f3249f399546b8bd322c9db","type":"text","conversion_output":true,"text":"palliative chemotherapy. There were 770 cancer patients who chose chemotherapy with","text_display":" palliative chemotherapy. There were 770 cancer patients who chose chemotherapy with","confidence":1,"confidence_rate":1},{"cnt":[[344,1848],[1852,1848],[1852,1897],[344,1897]],"region":{"top_left_x":343,"top_left_y":1847,"width":1509,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b4874ecbe5a4826acecdbacb4e84867","type":"text","conversion_output":true,"text":"scalp cooling and 141 who chose to have chemotherapy without scalp cooling. During the","text_display":" scalp cooling and 141 who chose to have chemotherapy without scalp cooling. During the","confidence":1,"confidence_rate":1},{"cnt":[[344,1895],[1824,1895],[1824,1944],[344,1944]],"region":{"top_left_x":343,"top_left_y":1894,"width":1482,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21df25102e4240279a9f24dcdbc4f82d","type":"text","conversion_output":true,"text":"follow-up, a minimum time of at least 2 years, there was one cutaneous scalp metastasis","text_display":" follow-up, a minimum time of at least 2 years, there was one cutaneous scalp metastasis","confidence":1,"confidence_rate":1},{"cnt":[[344,1942],[1751,1942],[1751,1996],[344,1996]],"region":{"top_left_x":343,"top_left_y":1942,"width":1408,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b1a4703ca1b439cb163d48e3960473e","type":"text","conversion_output":true,"text":"and two subcutaneous scalp metastases occurring among the patients who had scalp","text_display":" and two subcutaneous scalp metastases occurring among the patients who had scalp","confidence":1,"confidence_rate":1},{"cnt":[[344,1989],[1803,1989],[1803,2041],[344,2041]],"region":{"top_left_x":343,"top_left_y":1989,"width":1460,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5188d2b63b4642c2853ed9206d38783b","type":"text","conversion_output":true,"text":"cooling, and no scalp metastases among the patients who abstained from scalp cooling.","text_display":" cooling, and no scalp metastases among the patients who abstained from scalp cooling.","confidence":1,"confidence_rate":1},{"cnt":[[344,2041],[1828,2041],[1828,2090],[344,2090]],"region":{"top_left_x":343,"top_left_y":2041,"width":1486,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68d622731efe48a79302f3ab4602eab7","type":"text","conversion_output":true,"text":"The brief report does not give any indication of what kind of primaries the three patients","text_display":" The brief report does not give any indication of what kind of primaries the three patients","confidence":1,"confidence_rate":1},{"cnt":[[344,2088],[1818,2088],[1818,2138],[344,2138]],"region":{"top_left_x":343,"top_left_y":2088,"width":1475,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbf9bbca18dc47d5bee548b1854f9ac0","type":"text","conversion_output":true,"text":"with scalp metastases had, or if the chemotherapy was given as adjuvant treatment or as","text_display":" with scalp metastases had, or if the chemotherapy was given as adjuvant treatment or as","confidence":1,"confidence_rate":1},{"cnt":[[344,2136],[1044,2136],[1044,2185],[344,2185]],"region":{"top_left_x":343,"top_left_y":2135,"width":702,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd9bb998a3934d9991bdd0a40f9ec43d","type":"text","conversion_output":true,"text":"palliative treatment for advanced disease.","text_display":" palliative treatment for advanced disease.","confidence":1,"confidence_rate":1},{"cnt":[[344,2204],[1850,2204],[1850,2254],[344,2254]],"region":{"top_left_x":343,"top_left_y":2204,"width":1507,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ba3006e8ca24837998b710fb06a4553","type":"text","conversion_output":true,"text":"In 2009, Lemieux et al reported on a retrospective cohort study of women diagnosed with","text_display":"\n\nIn 2009, Lemieux et al reported on a retrospective cohort study of women diagnosed with","confidence":1,"confidence_rate":1},{"cnt":[[344,2252],[1846,2252],[1846,2301],[344,2301]],"region":{"top_left_x":343,"top_left_y":2251,"width":1503,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"469f17ce22dd4ff7872d42cd38128d5e","type":"text","conversion_output":true,"text":"invasive breast cancer between June 1998 and June 2002 at a single institution in Quebec","text_display":" invasive breast cancer between June 1998 and June 2002 at a single institution in Quebec","confidence":1,"confidence_rate":1},{"cnt":[[344,2299],[1824,2299],[1824,2348],[344,2348]],"region":{"top_left_x":343,"top_left_y":2298,"width":1482,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f85613c00ea443f89cf84fb4c69fb512","type":"text","conversion_output":true,"text":"(Lemieux 2009). Scalp cooling was routinely offered to women with breast cancer. Of a","text_display":" (Lemieux 2009). Scalp cooling was routinely offered to women with breast cancer. Of a","confidence":1,"confidence_rate":1},{"cnt":[[344,2346],[1734,2346],[1734,2398],[344,2398]],"region":{"top_left_x":343,"top_left_y":2346,"width":1391,"height":52},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb45b7fcbcd54e7a98291ee61b707f04","type":"text","conversion_output":true,"text":"total of 640 patients included, \\(86.4 \\%\\) received scalp cooling during neoadjuvant or","text_display":" total of 640 patients included, \\(86.4 \\%\\) received scalp cooling during neoadjuvant or","confidence":0.99658203125,"confidence_rate":0.9999631853728411},{"cnt":[[344,2396],[1807,2396],[1807,2447],[344,2447]],"region":{"top_left_x":343,"top_left_y":2395,"width":1464,"height":53},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6135c42c4e86489e8aff7e9037d33ddf","type":"text","conversion_output":true,"text":"adjuvant chemotherapy. Six patients (1.1\\%) in the scalp cooling group developed scalp","text_display":" adjuvant chemotherapy. 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The rate of scalp metastases in the scalp cooling","text_display":"\none patient in the control group ( \\(1.2 \\%\\) ). The rate of scalp metastases in the scalp cooling","confidence":0.8878040313720703,"confidence_rate":0.998810665362355},{"cnt":[[346,301],[1850,301],[1850,350],[346,350]],"region":{"top_left_x":345,"top_left_y":300,"width":1505,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca53d2c555564cdcafacc11e3c7c9fef","type":"text","conversion_output":true,"text":"group and the control group was not statistically different. In this cohort, scalp metastases","text_display":" group and the control group was not statistically different. 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As of","text_display":" the analysis; 48\\% of them had hair preservation defined as not needing a head cover. As of","confidence":0.92919921875,"confidence_rate":0.9992273289918546},{"cnt":[[344,1345],[1820,1345],[1820,1396],[344,1396]],"region":{"top_left_x":343,"top_left_y":1344,"width":1477,"height":53},"line":105,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b04810a25da4a559f8f55d5cbd5f187","type":"text","conversion_output":true,"text":"November 2011 no scalp metastasis had been reported. This study also standardized the","text_display":" November 2011 no scalp metastasis had been reported. This study also standardized the","confidence":1,"confidence_rate":1},{"cnt":[[344,1394],[1876,1394],[1876,1446],[344,1446]],"region":{"top_left_x":343,"top_left_y":1394,"width":1533,"height":52},"line":106,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ed646907cdb41e59a249a7faacf2994","type":"text","conversion_output":true,"text":"cooling times with a 30 minute pre-cooling time and a 90 minute post-cooling time ( C . van","text_display":" cooling times with a 30 minute pre-cooling time and a 90 minute post-cooling time ( C . van","confidence":0.9985356330871582,"confidence_rate":0.9999864312018168},{"cnt":[[344,1444],[1800,1444],[1800,1493],[344,1493]],"region":{"top_left_x":343,"top_left_y":1443,"width":1458,"height":51},"line":107,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e79627ac477429698860995117377f7","type":"text","conversion_output":true,"text":"den Hurk 2011). The second poster was from Canada and looked at survival in women","text_display":" den Hurk 2011). The second poster was from Canada and looked at survival in women","confidence":1,"confidence_rate":1},{"cnt":[[344,1491],[1764,1491],[1764,1540],[344,1540]],"region":{"top_left_x":343,"top_left_y":1491,"width":1421,"height":50},"line":108,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c95e85c05bf64d63bae90ca771364463","type":"text","conversion_output":true,"text":"with breast cancer who used or did not use a scalp cooling device in the neoadjuvant","text_display":" with breast cancer who used or did not use a scalp cooling device in the neoadjuvant","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[344,1538],[1757,1538],[1757,1588],[344,1588]],"region":{"top_left_x":343,"top_left_y":1538,"width":1415,"height":50},"line":109,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"034fc874abde4bfcb58b95113656aeda","type":"text","conversion_output":true,"text":"/adjuvant setting. This was a retrospective study of 1,370 women with breast cancer","text_display":" /adjuvant setting. This was a retrospective study of 1,370 women with breast cancer","confidence":0.9970703125,"confidence_rate":0.999967758899593},{"cnt":[[344,1586],[1867,1586],[1867,1635],[344,1635]],"region":{"top_left_x":343,"top_left_y":1585,"width":1524,"height":50},"line":110,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b6c20034da74b71bad8c5bf859a4ceb","type":"text","conversion_output":true,"text":"diagnosed between June 1998 and June 2002. There was no difference in survival between","text_display":" diagnosed between June 1998 and June 2002. There was no difference in survival between","confidence":1,"confidence_rate":1},{"cnt":[[344,1633],[1091,1633],[1091,1687],[344,1687]],"region":{"top_left_x":343,"top_left_y":1632,"width":749,"height":55},"line":111,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dcadf871df64cffa452c4a1adc4b1ea","type":"text","conversion_output":true,"text":"these 2 groups of women (J Lemieux 2011).","text_display":" these 2 groups of women (J Lemieux 2011).","confidence":1,"confidence_rate":1},{"cnt":[[344,1702],[1798,1702],[1798,1755],[344,1755]],"region":{"top_left_x":343,"top_left_y":1701,"width":1456,"height":55},"line":112,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"349cd25bcbed40fe954baa018da7dfe6","type":"text","conversion_output":true,"text":"In the past there has been a theoretical concern for scalp metastases. The literature and","text_display":"\nIn the past there has been a theoretical concern for scalp metastases. The literature and","confidence":1,"confidence_rate":1},{"cnt":[[344,1749],[1781,1749],[1781,1800],[344,1800]],"region":{"top_left_x":343,"top_left_y":1748,"width":1439,"height":53},"line":113,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27238dc984004591b1addb4e3e788e7f","type":"text","conversion_output":true,"text":"studies to date clearly show that there is not an increased rate of scalp metastases or a","text_display":" studies to date clearly show that there is not an increased rate of scalp metastases or a","confidence":1,"confidence_rate":1},{"cnt":[[344,1798],[1846,1798],[1846,1850],[344,1850]],"region":{"top_left_x":343,"top_left_y":1798,"width":1503,"height":52},"line":114,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e2d40d2203745c787b836cd362678a0","type":"text","conversion_output":true,"text":"difference in survival compared to women who did not receive scalp cooling. The known","text_display":" difference in survival compared to women who did not receive scalp cooling. The known","confidence":1,"confidence_rate":1},{"cnt":[[344,1848],[1850,1848],[1850,1897],[344,1897]],"region":{"top_left_x":343,"top_left_y":1847,"width":1507,"height":51},"line":115,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01a6e93e9e4b4971953be8294df5035d","type":"text","conversion_output":true,"text":"rate of scalp metastases in breast cancer patients is \\(<2.5 \\%\\). The rate of scalp metastases in","text_display":" rate of scalp metastases in breast cancer patients is \\(<2.5 \\%\\). The rate of scalp metastases in","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[344,1895],[1794,1895],[1794,1944],[344,1944]],"region":{"top_left_x":343,"top_left_y":1894,"width":1451,"height":51},"line":116,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"510032578b3648d18c7600d7bef0916b","type":"text","conversion_output":true,"text":"review of the NSABP data by Rugo and Melin as a single site is \\(0.025 \\%\\) (Rugo 2010).","text_display":" review of the NSABP data by Rugo and Melin as a single site is \\(0.025 \\%\\) (Rugo 2010).","confidence":0.99853515625,"confidence_rate":0.9999837121583983},{"cnt":[[344,1942],[1863,1942],[1863,1994],[344,1994]],"region":{"top_left_x":343,"top_left_y":1942,"width":1520,"height":52},"line":117,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fc8e4fa41294b8aa193d0b1f22f859d","type":"text","conversion_output":true,"text":"The rate of scalp metastasis in women with breast cancer is very small, and as a single site","text_display":" The rate of scalp metastasis in women with breast cancer is very small, and as a single site","confidence":1,"confidence_rate":1},{"cnt":[[344,1989],[1751,1989],[1751,2041],[344,2041]],"region":{"top_left_x":343,"top_left_y":1989,"width":1408,"height":53},"line":118,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6d92a8809be47e585a058ce48edb5e5","type":"text","conversion_output":true,"text":"of recurrence is exceedingly rare. If a patient has scalp metastases, there are usually","text_display":" of recurrence is exceedingly rare. If a patient has scalp metastases, there are usually","confidence":1,"confidence_rate":1},{"cnt":[[344,2039],[1747,2039],[1747,2090],[344,2090]],"region":{"top_left_x":343,"top_left_y":2038,"width":1404,"height":53},"line":119,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb38929d407841969f133757112fedf2","type":"text","conversion_output":true,"text":"multiple other sites of metastatic disease and there are usually other sites cutaneous","text_display":" multiple other sites of metastatic disease and there are usually other sites cutaneous","confidence":1,"confidence_rate":1},{"cnt":[[344,2088],[1777,2088],[1777,2138],[344,2138]],"region":{"top_left_x":343,"top_left_y":2088,"width":1434,"height":50},"line":120,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffe0fa137d9e41e895cc8eb411ffebb4","type":"text","conversion_output":true,"text":"metastases. Studies done to date do not show an increase in scalp metastasis in breast","text_display":" metastases. Studies done to date do not show an increase in scalp metastasis in breast","confidence":1,"confidence_rate":1},{"cnt":[[344,2136],[1336,2136],[1336,2185],[344,2185]],"region":{"top_left_x":343,"top_left_y":2135,"width":994,"height":50},"line":121,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de2d5bd6230f4f0599250ec93ff1b124","type":"text","conversion_output":true,"text":"cancer patients receiving scalp cooling to prevent alopecia.","text_display":" cancer patients receiving scalp cooling to prevent alopecia.","confidence":1,"confidence_rate":1},{"cnt":[[348,2221],[1154,2221],[1154,2288],[348,2288]],"region":{"top_left_x":348,"top_left_y":2221,"width":806,"height":68},"line":122,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b439c445627b4f179e1b76a1f5193d44","type":"section_header","conversion_output":false,"children_ids":["bdfd580b49e44fb399273fc9bb60a8e9"],"text":"","text_display":""},{"cnt":[[354,2228],[1145,2228],[1145,2284],[354,2284]],"region":{"top_left_x":354,"top_left_y":2227,"width":792,"height":57},"line":123,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdfd580b49e44fb399273fc9bb60a8e9","type":"text","conversion_output":true,"parent_id":"b439c445627b4f179e1b76a1f5193d44","text":"C. 5 Other Side Effects with Scalp Cooling","text_display":"\n\n\\section*{C. 5 Other Side Effects with Scalp Cooling}","confidence":1,"confidence_rate":1},{"cnt":[[346,2299],[1813,2299],[1813,2348],[346,2348]],"region":{"top_left_x":345,"top_left_y":2298,"width":1469,"height":51},"line":124,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"428b2ae689f44a6f95602ec0c21a4d63","type":"text","conversion_output":true,"text":"The effect of scalp cooling on patient comfort, possible side effects, and well-being has","text_display":"\n\nThe effect of scalp cooling on patient comfort, possible side effects, and well-being has","confidence":1,"confidence_rate":1},{"cnt":[[346,2346],[1841,2346],[1841,2396],[346,2396]],"region":{"top_left_x":345,"top_left_y":2346,"width":1497,"height":50},"line":125,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5a9121e43a049faaa68e609272c3468","type":"text","conversion_output":true,"text":"been evaluated. Based on published accounts of more than 2,000 patients, it is concluded","text_display":" been evaluated. Based on published accounts of more than 2,000 patients, it is concluded","confidence":0.658203125,"confidence_rate":0.9955128748393284},{"cnt":[[344,2393],[1867,2393],[1867,2447],[344,2447]],"region":{"top_left_x":343,"top_left_y":2393,"width":1524,"height":55},"line":126,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fc49b7e77854aa28907389fa27a7d90","type":"text","conversion_output":true,"text":"that the majority of patients tolerate scalp cooling very well (Breed 2004). The side effects","text_display":" that the majority of patients tolerate scalp cooling very well (Breed 2004). The side effects","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[1038,2557],[1089,2557],[1089,2610],[1038,2610]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":55},"line":127,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24eac30ecbbc4ed9a19adab87afe5304","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-16","page":16,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98b2398076b1406294632ad7f02213ba","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f582cd0ab7e4995b1b2bea768288d70","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[344,249],[1813,249],[1813,303],[344,303]],"region":{"top_left_x":343,"top_left_y":249,"width":1471,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afbbca54b9ef401eab9376f3f6298e22","type":"text","conversion_output":true,"text":"of scalp cooling are not frequent and are not serious. Side effects are rarely a reason for","text_display":"\nof scalp cooling are not frequent and are not serious. Side effects are rarely a reason for","confidence":1,"confidence_rate":1},{"cnt":[[344,301],[703,301],[703,350],[344,350]],"region":{"top_left_x":343,"top_left_y":300,"width":360,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb311beb8c884ae89c0631c8c588abc9","type":"text","conversion_output":true,"text":"stopping the cooling.","text_display":" stopping the cooling.","confidence":1,"confidence_rate":1},{"cnt":[[344,370],[1725,370],[1725,419],[344,419]],"region":{"top_left_x":343,"top_left_y":369,"width":1383,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df7197254d7e484d9556aa3166f1dab0","type":"text","conversion_output":true,"text":"Common side effects reported with scalp cooling include headache, complaints of","text_display":"\n\nCommon side effects reported with scalp cooling include headache, complaints of","confidence":1,"confidence_rate":1},{"cnt":[[346,417],[1669,417],[1669,466],[346,466]],"region":{"top_left_x":345,"top_left_y":416,"width":1325,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9920eaa6bdf41e3b451342be2eab61b","type":"text","conversion_output":true,"text":"coldness, and/or uncomfortable sensations, heavy feeling of the head, transient","text_display":" coldness, and/or uncomfortable sensations, heavy feeling of the head, transient","confidence":1,"confidence_rate":1},{"cnt":[[344,464],[1742,464],[1742,513],[344,513]],"region":{"top_left_x":343,"top_left_y":464,"width":1400,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad3423224e534f7284bebcc228dc8c44","type":"text","conversion_output":true,"text":"lightheadedness, and neck pain (Massey 2004). Uncomfortable cold sensations and","text_display":" lightheadedness, and neck pain (Massey 2004). Uncomfortable cold sensations and","confidence":1,"confidence_rate":1},{"cnt":[[344,511],[1775,511],[1775,563],[344,563]],"region":{"top_left_x":343,"top_left_y":511,"width":1432,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94f0127ed0f346cd83a9a87a90a751b0","type":"text","conversion_output":true,"text":"headaches were more frequently reported in studies when pre-cooled caps (which are","text_display":" headaches were more frequently reported in studies when pre-cooled caps (which are","confidence":1,"confidence_rate":1},{"cnt":[[344,561],[1837,561],[1837,610],[344,610]],"region":{"top_left_x":343,"top_left_y":560,"width":1494,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2dc383c47874a1b9ece62d4cc6707cf","type":"text","conversion_output":true,"text":"chilled to \\(-15^{\\circ} C\\) to \\(-25^{\\circ} C\\) ) were used. Patients also complain about a heavy feeling of the","text_display":" chilled to \\(-15^{\\circ} C\\) to \\(-25^{\\circ} C\\) ) were used. Patients also complain about a heavy feeling of the","confidence":0.9853763580322266,"confidence_rate":0.9998782584737889},{"cnt":[[344,608],[1691,608],[1691,657],[344,657]],"region":{"top_left_x":343,"top_left_y":608,"width":1348,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba71d228257c40688af2a886c5dcb0f4","type":"text","conversion_output":true,"text":"head and transient light-headedness following cap removal. In addition, patients","text_display":" head and transient light-headedness following cap removal. In addition, patients","confidence":1,"confidence_rate":1},{"cnt":[[344,657],[1867,657],[1867,707],[344,707]],"region":{"top_left_x":343,"top_left_y":657,"width":1524,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb1c4208bb0e411a939095ed870a6aed","type":"text","conversion_output":true,"text":"experienced neck pain due to heavy weight of some cooling caps. Cold injuries have never","text_display":" experienced neck pain due to heavy weight of some cooling caps. Cold injuries have never","confidence":0.99755859375,"confidence_rate":0.9999737165675469},{"cnt":[[344,705],[1846,705],[1846,754],[344,754]],"region":{"top_left_x":343,"top_left_y":704,"width":1503,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14361c1bff594e4abb6712fb6aaeb4a6","type":"text","conversion_output":true,"text":"been reported. A potential disadvantage of scalp cooling is the additional pre-cooling and","text_display":" been reported. A potential disadvantage of scalp cooling is the additional pre-cooling and","confidence":1,"confidence_rate":1},{"cnt":[[344,752],[1841,752],[1841,801],[344,801]],"region":{"top_left_x":343,"top_left_y":751,"width":1499,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"894a140f20574c34a16f7730225662a0","type":"text","conversion_output":true,"text":"post-cooling time required which would have patients remain in the oncology clinic for a","text_display":" post-cooling time required which would have patients remain in the oncology clinic for a","confidence":1,"confidence_rate":1},{"cnt":[[344,799],[621,799],[621,849],[344,849]],"region":{"top_left_x":343,"top_left_y":799,"width":278,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e217c1f4020841ee8fd4b584fae2c74d","type":"text","conversion_output":true,"text":"longer duration.","text_display":" longer 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System (based on clinical experience with","confidence":1,"confidence_rate":1},{"cnt":[[344,965],[1876,965],[1876,1016],[344,1016]],"region":{"top_left_x":343,"top_left_y":964,"width":1533,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65d474ded6f94c758a99dc5deebc8ffb","type":"text","conversion_output":true,"text":"scalp cooling, including that obtained from use of the previous PSC model of scalp cooling","text_display":" scalp cooling, including that obtained from use of the previous PSC model of scalp cooling","confidence":1,"confidence_rate":1},{"cnt":[[344,1014],[1313,1014],[1313,1063],[344,1063]],"region":{"top_left_x":343,"top_left_y":1014,"width":970,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1800a013b7644db9ba963a1d3448f310","type":"text","conversion_output":true,"text":"system manufactured by Paxman Coolers) are as follows:","text_display":" system manufactured by Paxman 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scalp cooling)","confidence":1,"confidence_rate":1},{"cnt":[[387,1195],[1841,1195],[1841,1248],[387,1248]],"region":{"top_left_x":386,"top_left_y":1194,"width":1456,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"705eedbdc20b45d89f5292acc8089ff9","type":"text","conversion_output":true,"text":"- forehead pain (during scalp cooling) resulting from pressure and tightness from the","text_display":"\n- forehead pain (during scalp cooling) resulting from pressure and tightness from the","confidence":1,"confidence_rate":1},{"cnt":[[447,1246],[651,1246],[651,1296],[447,1296]],"region":{"top_left_x":446,"top_left_y":1246,"width":205,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2ecb03dc8284abd8b351572cc3d463a","type":"text","conversion_output":true,"text":"cooling cap","text_display":" cooling 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scalp","text_display":"\n- the rate of incidence of scalp metastases in patients who have undergone scalp","confidence":1,"confidence_rate":1},{"cnt":[[447,524],[1820,522],[1820,571],[447,574]],"region":{"top_left_x":446,"top_left_y":521,"width":1374,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"968a1c1165ec46068570e53a5d19f49b","type":"text","conversion_output":true,"text":"cooling during chemotherapy is low ( \\(1.1 \\%\\) ) and is not significantly different from","text_display":" cooling during chemotherapy is low ( \\(1.1 \\%\\) ) and is not significantly different from","confidence":0.990234375,"confidence_rate":0.9998921638208011},{"cnt":[[447,571],[1762,571],[1762,621],[447,621]],"region":{"top_left_x":446,"top_left_y":571,"width":1316,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d28c986a67c74901ac454f2b765ae650","type":"text","conversion_output":true,"text":"the incidence of scalp metastases in patients who did not receive scalp cooling","text_display":" the incidence of scalp metastases in patients who did not receive scalp cooling","confidence":1,"confidence_rate":1},{"cnt":[[447,619],[569,619],[569,664],[447,664]],"region":{"top_left_x":446,"top_left_y":618,"width":124,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b889c80d3c6460a8998c9f8c8a4c973","type":"text","conversion_output":true,"text":"(1.2\\%)","text_display":" (1.2\\%)","confidence":1,"confidence_rate":1},{"cnt":[[387,679],[1876,679],[1876,728],[387,728]],"region":{"top_left_x":386,"top_left_y":678,"width":1490,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14f3d72b16aa4428bf3ecfd522f51781","type":"text","conversion_output":true,"text":"- there is not an increased rate of scalp metastases or a difference in survival compared","text_display":"\n- there is not an increased rate of scalp metastases or a difference in survival compared","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[447,726],[1195,726],[1195,776],[447,776]],"region":{"top_left_x":446,"top_left_y":726,"width":749,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"746b077c0e794a87bba4acbfdf2ca5c9","type":"text","conversion_output":true,"text":"to women who did not receive scalp cooling","text_display":" to women who did not receive scalp cooling","confidence":1,"confidence_rate":1},{"cnt":[[346,795],[1777,795],[1777,844],[346,844]],"region":{"top_left_x":345,"top_left_y":794,"width":1432,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd8d4324de3040a783b91fb3092772f0","type":"text","conversion_output":true,"text":"Given that the this study is specifically designed to investigate scalp cooling in breast","text_display":"\n\nGiven that the this study is specifically designed to investigate scalp cooling in breast","confidence":1,"confidence_rate":1},{"cnt":[[344,844],[1835,844],[1835,892],[344,892]],"region":{"top_left_x":343,"top_left_y":844,"width":1492,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"901ed60fe32d436d83d0b33c5cf6068c","type":"text","conversion_output":true,"text":"cancer patients who are newly diagnosed with stage I - II breast cancer, and that patients","text_display":" cancer patients who are newly diagnosed with stage I - II breast cancer, and that patients","confidence":0.9819650650024414,"confidence_rate":0.9998084441742718},{"cnt":[[344,889],[1732,889],[1732,939],[344,939]],"region":{"top_left_x":343,"top_left_y":889,"width":1389,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d3b60100e724726812c2c1f75b9da11","type":"text","conversion_output":true,"text":"with a history of scalp metastases, or with any other metastatic site are specifically","text_display":" with a history of scalp metastases, or with any other metastatic site are specifically","confidence":1,"confidence_rate":1},{"cnt":[[344,939],[1867,939],[1867,986],[344,986]],"region":{"top_left_x":343,"top_left_y":938,"width":1524,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bebb49bb71dd4d31b12f20efb53bb7d1","type":"text","conversion_output":true,"text":"excluded from enrollment, then it is considered that the risk relating to increased incidence","text_display":" excluded from enrollment, then it is considered that the risk relating to increased incidence","confidence":1,"confidence_rate":1},{"cnt":[[344,988],[1809,988],[1809,1036],[344,1036]],"region":{"top_left_x":343,"top_left_y":988,"width":1466,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60263d11a5474ca69206513b490bc482","type":"text","conversion_output":true,"text":"of scalp metastases is low. In particular, this risk is outweighed by the potential clinical","text_display":" of scalp metastases is low. 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As such, the potential clinical benefits to the patient associated hair","text_display":" significance. 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At the time this concern was initially raised","text_display":" is an increased incidence of scalp metastases. At the time this concern was initially raised","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":53},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09bd4c5392494f089c44b27d9d4a52d6","type":"page_info","conversion_output":false,"text":"20","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-21","page":21,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ca389c6ab894226909de2a22cdcf645","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention 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risk.","confidence":1,"confidence_rate":1},{"cnt":[[370,301],[1807,301],[1807,350],[370,350]],"region":{"top_left_x":369,"top_left_y":300,"width":1438,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3e1ca80511546f492ee4c8dbb1c3d3d","type":"text","conversion_output":true,"text":"However, since that time, a number of published studies extending out to more than 5","text_display":" However, since that time, a number of published studies extending out to more than 5","confidence":1,"confidence_rate":1},{"cnt":[[370,348],[1248,348],[1248,397],[370,397]],"region":{"top_left_x":369,"top_left_y":348,"width":880,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ac3875d5eb74c31a3b4241c3c0b0f52","type":"text","conversion_output":true,"text":"years (described in section C.4) have identified that:","text_display":" years (described in section C.4) have identified 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chemotherapy is low ( \\(1.1 \\%\\) ) and is not significantly different from","text_display":" cooling during chemotherapy is low ( \\(1.1 \\%\\) ) and is not significantly different from","confidence":0.67446184810251,"confidence_rate":0.9956814379873636},{"cnt":[[447,724],[1764,724],[1764,776],[447,776]],"region":{"top_left_x":446,"top_left_y":724,"width":1318,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d564b83daaa4582bfc2a17c6b7b169c","type":"text","conversion_output":true,"text":"the incidence of scalp metastases in patients who did not receive scalp cooling","text_display":" the incidence of scalp metastases in patients who did not receive scalp 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history of scalp metastases or with any other metastatic site are specifically excluded","confidence":1,"confidence_rate":1},{"cnt":[[370,1091],[1876,1091],[1876,1141],[370,1141]],"region":{"top_left_x":369,"top_left_y":1091,"width":1507,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11038b0e4aa3451d8a1db57d2ffe153e","type":"text","conversion_output":true,"text":"from enrollment, then it is considered that the risk relating to increased incidence of scalp","text_display":" from enrollment, then it is considered that the risk relating to increased incidence of scalp","confidence":1,"confidence_rate":1},{"cnt":[[370,1141],[1878,1141],[1878,1190],[370,1190]],"region":{"top_left_x":369,"top_left_y":1140,"width":1509,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ee83674284e4935bd760a661925f970","type":"text","conversion_output":true,"text":"metastases is low. 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For some subjects, the cap fitting process will","text_display":" duration of the scalp cooling process. For some subjects, the cap fitting process will","confidence":1,"confidence_rate":1},{"cnt":[[370,2200],[1846,2200],[1846,2249],[370,2249]],"region":{"top_left_x":369,"top_left_y":2200,"width":1477,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08cd0cad2da54fc3a14f65fee511c753","type":"text","conversion_output":true,"text":"simply involve the selection of the most appropriate size cooling cap and corresponding","text_display":" simply involve the selection of the most appropriate size cooling cap and corresponding","confidence":1,"confidence_rate":1},{"cnt":[[370,2247],[1850,2247],[1850,2297],[370,2297]],"region":{"top_left_x":369,"top_left_y":2247,"width":1481,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6be32986680e4224b608c00b8770acf2","type":"text","conversion_output":true,"text":"cap cover. For subjects whose head size does not correspond to one of the five available","text_display":" cap cover. For subjects whose head size does not correspond to one of the five available","confidence":1,"confidence_rate":1},{"cnt":[[370,2295],[1835,2295],[1835,2346],[370,2346]],"region":{"top_left_x":369,"top_left_y":2294,"width":1466,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d51293ee67674eb297f82fdef4574fe7","type":"text","conversion_output":true,"text":"cooling cap sizes, a combination of the larger size cooling cap and smaller size cover is","text_display":" cooling cap sizes, a combination of the larger size cooling cap and smaller size cover is","confidence":1,"confidence_rate":1},{"cnt":[[370,2342],[1412,2342],[1412,2396],[370,2396]],"region":{"top_left_x":369,"top_left_y":2341,"width":1043,"height":55},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbf483896eff4a818c51188f121bea20","type":"text","conversion_output":true,"text":"used to obtain the required cooling cap contact with the scalp.","text_display":" used to obtain the required cooling cap contact with the scalp.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddd70ef3e24b4ca4b2d6fcb8f5a3f9ed","type":"page_info","conversion_output":false,"text":"27","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-28","page":28,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dd3bcb6c6fe49668c80e4e38d2a21e8","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc196b6b0208446492f940b31af168a8","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,249],[1830,249],[1830,303],[370,303]],"region":{"top_left_x":369,"top_left_y":249,"width":1462,"height":54},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e7ee6939bb4467792b35cfe6c827510","type":"text","conversion_output":true,"text":"Selection and fitting of the optimum size of cooling cap and cooling cap cover for each","text_display":"\n\nSelection and fitting of the optimum size of cooling cap and cooling cap cover for each","confidence":1,"confidence_rate":1},{"cnt":[[370,301],[1871,301],[1871,350],[370,350]],"region":{"top_left_x":369,"top_left_y":300,"width":1503,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36051aeb792f4f20a104713ad631bcff","type":"text","conversion_output":true,"text":"subject will be performed in accordance with the instructions provided in the user manual","text_display":" subject will be performed in accordance with the instructions provided in the user manual","confidence":1,"confidence_rate":1},{"cnt":[[370,348],[1876,348],[1876,397],[370,397]],"region":{"top_left_x":369,"top_left_y":348,"width":1507,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"baf53691e08e4ef5a8a0bf80253a8de0","type":"text","conversion_output":true,"text":"supplied with the Orbis Paxman Hair Loss Prevention System. The user manual describes","text_display":" supplied with the Orbis Paxman Hair Loss Prevention System. The user manual describes","confidence":1,"confidence_rate":1},{"cnt":[[370,397],[1751,397],[1751,445],[370,445]],"region":{"top_left_x":369,"top_left_y":397,"width":1382,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58a24694652a4a94bbdb5acd5fccfb15","type":"text","conversion_output":true,"text":"the use of both pre-cooled and warm caps. Either option can be chosen for patient","text_display":" the use of both pre-cooled and warm caps. Either option can be chosen for patient","confidence":1,"confidence_rate":1},{"cnt":[[370,443],[539,443],[539,488],[370,488]],"region":{"top_left_x":369,"top_left_y":442,"width":171,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1df81649e4747989909475e916d5adf","type":"text","conversion_output":true,"text":"tolerance.","text_display":" tolerance.","confidence":1,"confidence_rate":1},{"cnt":[[367,511],[1854,511],[1854,563],[367,563]],"region":{"top_left_x":367,"top_left_y":511,"width":1488,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f61d48a60a034b3a80b59fe45197b2ec","type":"text","conversion_output":true,"text":"A record will be maintained in the study file at each center of the size of cooling cap and","text_display":"\n\nA record will be maintained in the study file at each center of the size of cooling cap and","confidence":1,"confidence_rate":1},{"cnt":[[370,561],[1833,561],[1833,612],[370,612]],"region":{"top_left_x":369,"top_left_y":560,"width":1464,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3675921e829b49bdb83d1e6bbd5a7aee","type":"text","conversion_output":true,"text":"cap cover selected for each subject at that center as well as if the cap was pre-cooled or","text_display":" cap cover selected for each subject at that center as well as if the cap was pre-cooled or","confidence":1,"confidence_rate":1},{"cnt":[[370,608],[1820,608],[1820,657],[370,657]],"region":{"top_left_x":369,"top_left_y":608,"width":1451,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f19ddf0808aa484691a8afabc71c3108","type":"text","conversion_output":true,"text":"warm, based on the above process. The Principal Investigator will retain a copy of this","text_display":" warm, based on the above process. The Principal Investigator will retain a copy of this","confidence":1,"confidence_rate":1},{"cnt":[[367,657],[1003,657],[1003,707],[367,707]],"region":{"top_left_x":367,"top_left_y":657,"width":637,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8197e396ca7641cc8f0ad27b607f1996","type":"text","conversion_output":true,"text":"record from each participating center.","text_display":" record from each participating center.","confidence":1,"confidence_rate":1},{"cnt":[[241,741],[621,741],[621,799],[241,799]],"region":{"top_left_x":240,"top_left_y":741,"width":381,"height":59},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"899c9216569849bfa52921cbda700313","type":"section_header","conversion_output":false,"children_ids":["ed97e8a66d6e45629bddd44bd6a4401d"],"text":"","text_display":""},{"cnt":[[245,748],[617,748],[617,797],[245,797]],"region":{"top_left_x":244,"top_left_y":747,"width":373,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed97e8a66d6e45629bddd44bd6a4401d","type":"text","conversion_output":true,"parent_id":"899c9216569849bfa52921cbda700313","text":"K.3.2 Scalp Cooling","text_display":"\n\n\\section*{K.3.2 Scalp Cooling}","confidence":1,"confidence_rate":1},{"cnt":[[370,814],[1785,814],[1785,866],[370,866]],"region":{"top_left_x":369,"top_left_y":814,"width":1417,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e044b316822f4ccca709b8b43e9d820d","type":"text","conversion_output":true,"text":"Scalp cooling will occur with each dose of chemotherapy. Prior to scalp cooling, the","text_display":"\n\nScalp cooling will occur with each dose of chemotherapy. Prior to scalp cooling, the","confidence":1,"confidence_rate":1},{"cnt":[[370,864],[1833,864],[1833,913],[370,913]],"region":{"top_left_x":369,"top_left_y":863,"width":1464,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39e3d6013f724703b523c8243a48d9fb","type":"text","conversion_output":true,"text":"cooling cap is always attached to the subject's head with the cap disconnected from the","text_display":" cooling cap is always attached to the subject's head with the cap disconnected from the","confidence":1,"confidence_rate":1},{"cnt":[[370,911],[1858,911],[1858,960],[370,960]],"region":{"top_left_x":369,"top_left_y":910,"width":1490,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc66d88893bc43279a79d829f4b90d40","type":"text","conversion_output":true,"text":"coolant lines. Before placing the cooling cap on the subject's head, it is placed inside the","text_display":" coolant lines. 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The cooling cap and","text_display":" of the cover, such that the entire cooling cap is within the cover. 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The healthcare professional then checks the fit of the cooling","text_display":" comfortable for the subject. 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use","confidence":1,"confidence_rate":1},{"cnt":[[387,1916],[1388,1916],[1388,1966],[387,1966]],"region":{"top_left_x":386,"top_left_y":1916,"width":1002,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"135afd225728447eaedac63c34626019","type":"text","conversion_output":true,"text":"- side effects reported by the subject during scalp cooling","text_display":"\n- side effects reported by the subject during scalp cooling","confidence":1,"confidence_rate":1},{"cnt":[[387,1977],[1682,1977],[1682,2026],[387,2026]],"region":{"top_left_x":386,"top_left_y":1976,"width":1297,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"399ab0bd79ca460d90d241e7f7ec6f73","type":"text","conversion_output":true,"text":"- the time and duration of, and the reason for, any temporary, or permanent","text_display":"\n- the time and duration of, and the reason for, any temporary, or permanent","confidence":1,"confidence_rate":1},{"cnt":[[447,2024],[1124,2024],[1124,2073],[447,2073]],"region":{"top_left_x":446,"top_left_y":2023,"width":678,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a8a0135f8b0472c9c22ef9d195e5767","type":"text","conversion_output":true,"text":"interruption to the scalp cooling process","text_display":" interruption to the scalp cooling process","confidence":1,"confidence_rate":1},{"cnt":[[387,2084],[1828,2084],[1828,2133],[387,2133]],"region":{"top_left_x":386,"top_left_y":2083,"width":1443,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba5e465db3ee4454b437ae12bb600adc","type":"text","conversion_output":true,"text":"- the time of occurrence of any alarms or warning messages from the Orbis Paxman","text_display":"\n- the time of occurrence of any alarms or warning messages from the Orbis Paxman","confidence":0.9951171875,"confidence_rate":0.999942416100643},{"cnt":[[447,2133],[1326,2133],[1326,2185],[447,2185]],"region":{"top_left_x":446,"top_left_y":2133,"width":880,"height":52},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"288142f66fea41d4bd6a64e87663b5c5","type":"text","conversion_output":true,"text":"Hair Loss Prevention System used for scalp cooling","text_display":" Hair Loss Prevention System used for scalp cooling","confidence":1,"confidence_rate":1},{"cnt":[[387,2196],[1682,2196],[1682,2245],[387,2245]],"region":{"top_left_x":386,"top_left_y":2195,"width":1297,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b6a64f5c1b044c0b9d6e04689ca82ea","type":"text","conversion_output":true,"text":"- the time and duration of, and the reason for, any temporary, or permanent","text_display":"\n- the time and duration of, and the reason for, any temporary, or permanent","confidence":1,"confidence_rate":1},{"cnt":[[447,2243],[1287,2243],[1287,2292],[447,2292]],"region":{"top_left_x":446,"top_left_y":2242,"width":841,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69939a54cc364577ace51d5891ecf3f1","type":"text","conversion_output":true,"text":"interruption to the chemotherapy infusion process","text_display":" interruption to the chemotherapy infusion process","confidence":1,"confidence_rate":1},{"cnt":[[387,2303],[1523,2303],[1523,2355],[387,2355]],"region":{"top_left_x":386,"top_left_y":2303,"width":1138,"height":52},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65ff79b60eba4050b5f5f6216f7a2702","type":"text","conversion_output":true,"text":"- if a subject withdraws from the study, the reason for withdrawal","text_display":"\n- if a subject withdraws from the study, the reason for withdrawal","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60860a8f314c4d818f571de73c1cbc17","type":"page_info","conversion_output":false,"text":"29","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-30","page":30,"lines":[{"cnt":[[245,103],[1257,103],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":103,"width":1013,"height":41},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7023b60451db4332a40c5551844d70f4","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e1e3cf2c276489a822923d906bf72d9","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[243,249],[685,249],[685,299],[243,299]],"region":{"top_left_x":242,"top_left_y":249,"width":444,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dbe06ab2f924de989031923559605e8","type":"section_header","conversion_output":false,"children_ids":["88412978e541496992da7c3eca492615"],"text":"","text_display":""},{"cnt":[[245,254],[681,254],[681,294],[245,294]],"region":{"top_left_x":244,"top_left_y":253,"width":438,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88412978e541496992da7c3eca492615","type":"text","conversion_output":true,"parent_id":"7dbe06ab2f924de989031923559605e8","text":"K.3.3 Visit Assessments","text_display":"\n\n\\section*{K.3.3 Visit Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[370,322],[1876,322],[1876,370],[370,370]],"region":{"top_left_x":369,"top_left_y":322,"width":1507,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32ba2966fdc449cd8e8c8c1be4a596b4","type":"text","conversion_output":true,"text":"At baseline and after each cycle, subjects will have an alopecia assessment by a delegated","text_display":"\n\nAt baseline and after each cycle, subjects will have an alopecia assessment by a delegated","confidence":1,"confidence_rate":1},{"cnt":[[370,370],[1781,370],[1781,419],[370,419]],"region":{"top_left_x":369,"top_left_y":369,"width":1413,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b16be9b9c77450a97110e7c5b1b4cc1","type":"text","conversion_output":true,"text":"physician or nurse practitioner and a second independent healthcare provider who is","text_display":" physician or nurse practitioner and a second independent healthcare provider who is","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[370,417],[1697,417],[1697,466],[370,466]],"region":{"top_left_x":369,"top_left_y":416,"width":1329,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c6d6d1df8ba4b389f544b915c5946d5","type":"text","conversion_output":true,"text":"blinded to study treatment. The independent healthcare provider is a healthcare","text_display":" blinded to study treatment. The independent healthcare provider is a healthcare","confidence":1,"confidence_rate":1},{"cnt":[[370,464],[1850,464],[1850,513],[370,513]],"region":{"top_left_x":369,"top_left_y":464,"width":1481,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"511bcf5048054cef94738acd44719501","type":"text","conversion_output":true,"text":"professional (physician, nurse, medical assistant, or research coordinator) who is trained","text_display":" professional (physician, nurse, medical assistant, or research coordinator) who is trained","confidence":1,"confidence_rate":1},{"cnt":[[370,511],[1841,511],[1841,563],[370,563]],"region":{"top_left_x":369,"top_left_y":511,"width":1473,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"505af9a43a1648e28ec46bfd40251b97","type":"text","conversion_output":true,"text":"in alopecia assessment, who is fully independent from the study, and who is completely","text_display":" in alopecia assessment, who is fully independent from the study, and who is completely","confidence":1,"confidence_rate":1},{"cnt":[[370,561],[1764,561],[1764,610],[370,610]],"region":{"top_left_x":369,"top_left_y":560,"width":1395,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6493323da7b84b349e9d8e2d026d6843","type":"text","conversion_output":true,"text":"blinded to the subject's treatment. This alopecia assessment will be made using the","text_display":" blinded to the subject's treatment. This alopecia assessment will be made using the","confidence":1,"confidence_rate":1},{"cnt":[[370,608],[1803,608],[1803,657],[370,657]],"region":{"top_left_x":369,"top_left_y":608,"width":1434,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94ebad1c454d4a69aceeca9cbb27c5d7","type":"text","conversion_output":true,"text":"CTCAE v4.0 grading system. The independent observer will assess the subject either","text_display":" CTCAE v4.0 grading system. The independent observer will assess the subject either","confidence":1,"confidence_rate":1},{"cnt":[[370,655],[1863,655],[1863,707],[370,707]],"region":{"top_left_x":369,"top_left_y":655,"width":1494,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a81939488c744e81afc15de4172e217d","type":"text","conversion_output":true,"text":"before or after the subject sees the clinician. By signing the consent, the clinician and the","text_display":" before or after the subject sees the clinician. By signing the consent, the clinician and the","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[370,705],[1876,705],[1876,754],[370,754]],"region":{"top_left_x":369,"top_left_y":704,"width":1507,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f2eacbc65b945318f1a88c1e163ac9a","type":"text","conversion_output":true,"text":"subject agree not to tell the independent observer the subject's randomization assignment.","text_display":" subject agree not to tell the independent observer the subject's randomization assignment.","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[370,752],[1841,752],[1841,801],[370,801]],"region":{"top_left_x":369,"top_left_y":751,"width":1473,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67a4cdfa44cc47d3b066da3539eb2fab","type":"text","conversion_output":true,"text":"The alopecia assessment will always be performed prior to subjects receiving their next","text_display":" The alopecia assessment will always be performed prior to subjects receiving their next","confidence":1,"confidence_rate":1},{"cnt":[[370,799],[1852,799],[1852,849],[370,849]],"region":{"top_left_x":369,"top_left_y":799,"width":1483,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"554c3133902845a1b78e0ce70fbae4d2","type":"text","conversion_output":true,"text":"cycle of chemotherapy. Subjects will also perform their own alopecia assessment and be","text_display":" cycle of chemotherapy. Subjects will also perform their own alopecia assessment and be","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[370,849],[1828,849],[1828,896],[370,896]],"region":{"top_left_x":369,"top_left_y":848,"width":1460,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc0ce986af8e4d1f94989870db848ad7","type":"text","conversion_output":true,"text":"asked about wig and scarf use after each cycle using the CTCAE v4.0 and the alopecia","text_display":" asked about wig and scarf use after each cycle using the CTCAE v4.0 and the alopecia","confidence":1,"confidence_rate":1},{"cnt":[[370,896],[907,896],[907,947],[370,947]],"region":{"top_left_x":369,"top_left_y":895,"width":538,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"118511b9e8474a118b3f5a68259ee53a","type":"text","conversion_output":true,"text":"pictorial tool (see Appendix B).","text_display":" pictorial tool (see Appendix B).","confidence":1,"confidence_rate":1},{"cnt":[[370,965],[1876,965],[1876,1016],[370,1016]],"region":{"top_left_x":369,"top_left_y":964,"width":1507,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08a3d21a25f94adb9d9fd31b806538de","type":"text","conversion_output":true,"text":"Photographs of the heads of the first 25 subjects' enrolled from each site who complete at","text_display":"\nPhotographs of the heads of the first 25 subjects' enrolled from each site who complete at","confidence":1,"confidence_rate":1},{"cnt":[[370,1014],[1867,1014],[1867,1063],[370,1063]],"region":{"top_left_x":369,"top_left_y":1014,"width":1498,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7032d36261847f1a8bae67beaba2882","type":"text","conversion_output":true,"text":"least 1 cycle of chemotherapy will be taken at each alopecia assessment (until the subject","text_display":" least 1 cycle of chemotherapy will be taken at each alopecia assessment (until the subject","confidence":1,"confidence_rate":1},{"cnt":[[370,1061],[1790,1061],[1790,1111],[370,1111]],"region":{"top_left_x":369,"top_left_y":1061,"width":1421,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63d2c6a0ce624c628e11b35224007677","type":"text","conversion_output":true,"text":"develops grade 2 alopecia), and these photographs will be included in the final study","text_display":" develops grade 2 alopecia), and these photographs will be included in the final study","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[370,1109],[1807,1109],[1807,1158],[370,1158]],"region":{"top_left_x":369,"top_left_y":1108,"width":1438,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"baae669b62b54a60a060955642f7bba4","type":"text","conversion_output":true,"text":"report. For subjects enrolled after these 25 subjects, photographs will only be taken at","text_display":" report. For subjects enrolled after these 25 subjects, photographs will only be taken at","confidence":0.998046875,"confidence_rate":0.9999796352611579},{"cnt":[[370,1156],[1841,1156],[1841,1205],[370,1205]],"region":{"top_left_x":369,"top_left_y":1155,"width":1473,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dca95e9ef0ad4afd8048267201e256ef","type":"text","conversion_output":true,"text":"baseline, after 4 cycles, and after completion of chemotherapy (if receiving more than 4","text_display":" baseline, after 4 cycles, and after completion of chemotherapy (if receiving more than 4","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[370,1203],[1854,1203],[1854,1253],[370,1253]],"region":{"top_left_x":369,"top_left_y":1203,"width":1486,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b4112591569408fb2ffa86884cb6ea2","type":"text","conversion_output":true,"text":"cycles). If a subject develops grade 2 alopecia at a visit prior to the post-Cycle 4 or post-","text_display":" cycles). If a subject develops grade 2 alopecia at a visit prior to the post-Cycle 4 or post","confidence":1,"confidence_rate":1},{"cnt":[[370,1250],[1800,1250],[1800,1300],[370,1300]],"region":{"top_left_x":369,"top_left_y":1250,"width":1432,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b31da73158904a3c95a81f8defc33f80","type":"text","conversion_output":true,"text":"completion visit, photographs should be taken at the visit and do not need to be taken","text_display":"completion visit, photographs should be taken at the visit and do not need to be taken","confidence":1,"confidence_rate":1},{"cnt":[[370,1302],[780,1302],[780,1349],[370,1349]],"region":{"top_left_x":369,"top_left_y":1301,"width":411,"height":49},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c629367b8e6458bba576d89742bd61e","type":"text","conversion_output":true,"text":"from that point forward.","text_display":" from that point forward.","confidence":1,"confidence_rate":1},{"cnt":[[370,1369],[1876,1369],[1876,1420],[370,1420]],"region":{"top_left_x":369,"top_left_y":1368,"width":1507,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebdd13f2c2c94b59b9dcb0ee1c312244","type":"text","conversion_output":true,"text":"These photographs will be taken with a digital camera or camera phone in a well-lit exam","text_display":"\n\nThese photographs will be taken with a digital camera or camera phone in a well-lit exam","confidence":0.9873046875,"confidence_rate":0.9998626267851773},{"cnt":[[370,1418],[1865,1418],[1865,1467],[370,1467]],"region":{"top_left_x":369,"top_left_y":1417,"width":1496,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d916b0167b9746e1b21f4436127fab67","type":"text","conversion_output":true,"text":"room with the subject sitting and the photographer standing. There will be 5 photographs","text_display":" room with the subject sitting and the photographer standing. There will be 5 photographs","confidence":1,"confidence_rate":1},{"cnt":[[370,1465],[1871,1465],[1871,1515],[370,1515]],"region":{"top_left_x":369,"top_left_y":1465,"width":1503,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"803a3674994f4e5584a8df39dbe8fcc5","type":"text","conversion_output":true,"text":"taken which will include the following views: front hairline taken 8-12\" from the subject,","text_display":" taken which will include the following views: front hairline taken 8-12\" from the subject,","confidence":0.994140625,"confidence_rate":0.9999381428765046},{"cnt":[[370,1512],[1846,1512],[1846,1562],[370,1562]],"region":{"top_left_x":369,"top_left_y":1512,"width":1477,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df22e3e52d564eba80b2f7f429fb4a6a","type":"text","conversion_output":true,"text":"right side \\& left side taken 15-25\" from the subject, back of the head taken 15-25\" from","text_display":" right side \\& left side taken 15-25\" from the subject, back of the head taken 15-25\" from","confidence":0.982421875,"confidence_rate":0.9998093251168981},{"cnt":[[370,1560],[1396,1560],[1396,1609],[370,1609]],"region":{"top_left_x":369,"top_left_y":1559,"width":1028,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8297f0e252f4116acaf05d20962a5ad","type":"text","conversion_output":true,"text":"the subject, and top of the head taken 8-12\" from the subject.","text_display":" the subject, and top of the head taken 8-12\" from the subject.","confidence":1,"confidence_rate":1},{"cnt":[[370,1629],[1863,1629],[1863,1678],[370,1678]],"region":{"top_left_x":369,"top_left_y":1628,"width":1494,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"209ef12c05174145968fbea327f304e3","type":"text","conversion_output":true,"text":"The EORTC QLQ-C30, HADS, and BIS questionnaires will be administered at baseline,","text_display":"\n\nThe EORTC QLQ-C30, HADS, and BIS questionnaires will be administered at baseline,","confidence":1,"confidence_rate":1},{"cnt":[[370,1676],[1757,1676],[1757,1725],[370,1725]],"region":{"top_left_x":369,"top_left_y":1675,"width":1389,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ab821a94af04a8c9bc947e189717a06","type":"text","conversion_output":true,"text":"after 4 cycles of chemotherapy and after completion of chemotherapy (if subject is","text_display":" after 4 cycles of chemotherapy and after completion of chemotherapy (if subject is","confidence":0.9990234375,"confidence_rate":0.9999891440628391},{"cnt":[[370,1723],[1656,1723],[1656,1775],[370,1775]],"region":{"top_left_x":369,"top_left_y":1723,"width":1288,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"648d770be8a545dc87018ea33af7de60","type":"text","conversion_output":true,"text":"receiving more than 4 cycles). Immediately after each cycle, subjects will be","text_display":" receiving more than 4 cycles). Immediately after each cycle, subjects will be","confidence":1,"confidence_rate":1},{"cnt":[[370,1772],[1678,1772],[1678,1824],[370,1824]],"region":{"top_left_x":369,"top_left_y":1772,"width":1309,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6204809c509b4fcca4a1332f0fdfe75a","type":"text","conversion_output":true,"text":"administered a comfort scale after the scalp cooling device has been removed.","text_display":" administered a comfort scale after the scalp cooling device has been removed.","confidence":1,"confidence_rate":1},{"cnt":[[370,1841],[1721,1841],[1721,1893],[370,1893]],"region":{"top_left_x":369,"top_left_y":1841,"width":1352,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0063f22d8e2d40008c099ad609a162d3","type":"text","conversion_output":true,"text":"Duration of device use will depend on the type of chemotherapy the subject is","text_display":"\nDuration of device use will depend on the type of chemotherapy the subject is","confidence":0.9990234375,"confidence_rate":0.9999880849533282},{"cnt":[[370,1891],[1824,1891],[1824,1940],[370,1940]],"region":{"top_left_x":369,"top_left_y":1890,"width":1456,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5829e2557ba41289800d40f85fc3c04","type":"text","conversion_output":true,"text":"receiving, if the subject is assessed as having grade 2 alopecia during the study, and","text_display":" receiving, if the subject is assessed as having grade 2 alopecia during the study, and","confidence":1,"confidence_rate":1},{"cnt":[[370,1938],[1549,1938],[1549,1987],[370,1987]],"region":{"top_left_x":369,"top_left_y":1937,"width":1181,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff803eab670044f6a68d8768bff28c58","type":"text","conversion_output":true,"text":"will occur with each cycle of chemotherapy (maximum of 8 cycles).","text_display":" will occur with each cycle of chemotherapy (maximum of 8 cycles).","confidence":1,"confidence_rate":1},{"cnt":[[370,2007],[1747,2007],[1747,2056],[370,2056]],"region":{"top_left_x":369,"top_left_y":2006,"width":1378,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19e310843f9e463baa48a9e8eb304ba8","type":"text","conversion_output":true,"text":"Subjects who develop grade 2 alopecia (determined by the blinded independent","text_display":"\n\nSubjects who develop grade 2 alopecia (determined by the blinded independent","confidence":1,"confidence_rate":1},{"cnt":[[370,2054],[1837,2054],[1837,2103],[370,2103]],"region":{"top_left_x":369,"top_left_y":2053,"width":1468,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2d36865ae454ac3a78b9ed998f72932","type":"text","conversion_output":true,"text":"provider, the delegated physician/nurse practitioner and the subject) will discontinue","text_display":" provider, the delegated physician/nurse practitioner and the subject) will discontinue","confidence":1,"confidence_rate":1},{"cnt":[[370,2103],[1880,2103],[1880,2153],[370,2153]],"region":{"top_left_x":369,"top_left_y":2103,"width":1511,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa29ae6f578e41b882fbbd62668e1629","type":"text","conversion_output":true,"text":"alopecia assessments at subsequent visits. Photographs will only continue if the subject","text_display":" alopecia assessments at subsequent visits. Photographs will only continue if the subject","confidence":1,"confidence_rate":1},{"cnt":[[370,2151],[1678,2151],[1678,2198],[370,2198]],"region":{"top_left_x":369,"top_left_y":2150,"width":1309,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30bdbc9fb6a147b7b1da2e90fc7e7029","type":"text","conversion_output":true,"text":"elects to continue to wear the device after development of grade 2 alopecia.","text_display":" elects to continue to wear the device after development of grade 2 alopecia.","confidence":1,"confidence_rate":1},{"cnt":[[243,2239],[823,2239],[823,2292],[243,2292]],"region":{"top_left_x":242,"top_left_y":2238,"width":581,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbf2045c340143459aeef454d7a6e777","type":"section_header","conversion_output":false,"children_ids":["b03f3db8c9ec42be9dde1965d2233cf3"],"text":"","text_display":""},{"cnt":[[245,2243],[819,2243],[819,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2242,"width":575,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b03f3db8c9ec42be9dde1965d2233cf3","type":"text","conversion_output":true,"parent_id":"bbf2045c340143459aeef454d7a6e777","text":"K.3.4 Control Group Procedures","text_display":"\n\n\\section*{K.3.4 Control Group Procedures}","confidence":1,"confidence_rate":1},{"cnt":[[339,2307],[1796,2307],[1796,2357],[339,2357]],"region":{"top_left_x":339,"top_left_y":2307,"width":1458,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"feb75f5a52374ee8afc0d384ccef621c","type":"text","conversion_output":true,"text":"Administration of the chemotherapy agent will be performed according to the standard","text_display":"\n\nAdministration of the chemotherapy agent will be performed according to the standard","confidence":1,"confidence_rate":1},{"cnt":[[339,2359],[1729,2359],[1729,2408],[339,2408]],"region":{"top_left_x":339,"top_left_y":2358,"width":1391,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50bfa6e5abdd49e0bc3bf1693a8ab632","type":"text","conversion_output":true,"text":"procedure at each center for the intravenous infusion of the chemotherapy regimen","text_display":" procedure at each center for the intravenous infusion of the chemotherapy regimen","confidence":1,"confidence_rate":1},{"cnt":[[339,2406],[1871,2406],[1871,2456],[339,2456]],"region":{"top_left_x":339,"top_left_y":2406,"width":1533,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc1da6bfefc24de2a345ef0418f55ae7","type":"text","conversion_output":true,"text":"concerned, using the recommended volume and infusion rate for the specific chemotherapy","text_display":" concerned, using the recommended volume and infusion rate for the specific chemotherapy","confidence":1,"confidence_rate":1},{"cnt":[[339,2454],[496,2454],[496,2503],[339,2503]],"region":{"top_left_x":339,"top_left_y":2453,"width":158,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e73a196c39e748f8912837f5b72bd5fe","type":"text","conversion_output":true,"text":"regimen.","text_display":" regimen.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":53},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5484095a8e2451cb4ba107a7dca525d","type":"page_info","conversion_output":false,"text":"30","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-31","page":31,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eda9d442880c4f0d859f8be0038d23fc","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"061a1c42b5204d8ea9cc5f92e7922e92","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[339,251],[1848,251],[1848,303],[339,303]],"region":{"top_left_x":339,"top_left_y":251,"width":1509,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30d91cbf97714c5f990544ccb6dc52fc","type":"text","conversion_output":true,"text":"At baseline and after each cycle, subjects will have an alopecia assessment by a physician","text_display":"\n\nAt baseline and after each cycle, subjects will have an alopecia assessment by a physician","confidence":1,"confidence_rate":1},{"cnt":[[339,301],[1824,301],[1824,350],[339,350]],"region":{"top_left_x":339,"top_left_y":300,"width":1486,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4331f65c35e64f088b6b6d504d1753b5","type":"text","conversion_output":true,"text":"or nurse practitioner and a second healthcare provider who is blinded to study treatment.","text_display":" or nurse practitioner and a second healthcare provider who is blinded to study treatment.","confidence":1,"confidence_rate":1},{"cnt":[[339,348],[1876,348],[1876,397],[339,397]],"region":{"top_left_x":339,"top_left_y":348,"width":1537,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"152041c2e1284bfeb8280220cb2ba75e","type":"text","conversion_output":true,"text":"The independent healthcare provider is a healthcare professional (physician, nurse, medical","text_display":" The independent healthcare provider is a healthcare professional (physician, nurse, medical","confidence":1,"confidence_rate":1},{"cnt":[[339,397],[1757,397],[1757,445],[339,445]],"region":{"top_left_x":339,"top_left_y":397,"width":1419,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c4fa4becd23445bbbce8d9b38ec4da0","type":"text","conversion_output":true,"text":"assistant or research coordinator) who is trained in alopecia assessment, who is fully","text_display":" assistant or research coordinator) who is trained in alopecia assessment, who is fully","confidence":1,"confidence_rate":1},{"cnt":[[339,443],[1867,443],[1867,492],[339,492]],"region":{"top_left_x":339,"top_left_y":442,"width":1528,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"393b76756cde43f8b931f0dc279d3e5a","type":"text","conversion_output":true,"text":"independent from the study, and who is completely blinded to the subject's treatment. This","text_display":" independent from the study, and who is completely blinded to the subject's treatment. This","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[339,492],[1880,492],[1880,544],[339,544]],"region":{"top_left_x":339,"top_left_y":491,"width":1541,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7de323a989544cc3ab9239b59f9d0923","type":"text","conversion_output":true,"text":"alopecia assessment will be made using the CTCAE v4.0 grading system. The independent","text_display":" alopecia assessment will be made using the CTCAE v4.0 grading system. The independent","confidence":1,"confidence_rate":1},{"cnt":[[339,539],[1781,539],[1781,591],[339,591]],"region":{"top_left_x":339,"top_left_y":539,"width":1443,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"469b269689d54116a73902691819057a","type":"text","conversion_output":true,"text":"observer will assess the subject either before or after the subject sees the clinician. By","text_display":" observer will assess the subject either before or after the subject sees the clinician. By","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[339,589],[1858,589],[1858,638],[339,638]],"region":{"top_left_x":339,"top_left_y":588,"width":1520,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62c6398788be4bd6934140ff021ff925","type":"text","conversion_output":true,"text":"signing the consent, the clinician and the subject agree not to tell the independent observer","text_display":" signing the consent, the clinician and the subject agree not to tell the independent observer","confidence":1,"confidence_rate":1},{"cnt":[[339,636],[1876,636],[1876,685],[339,685]],"region":{"top_left_x":339,"top_left_y":635,"width":1537,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fbc846cd44a4e57bf2aff773c5599d1","type":"text","conversion_output":true,"text":"the subject's randomization assignment. The alopecia assessment will always be performed","text_display":" the subject's randomization assignment. The alopecia assessment will always be performed","confidence":1,"confidence_rate":1},{"cnt":[[339,683],[1803,683],[1803,733],[339,733]],"region":{"top_left_x":339,"top_left_y":683,"width":1464,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"795eaf8123874517896943dd698f0e0c","type":"text","conversion_output":true,"text":"prior to subjects receiving their next cycle of chemotherapy. Subjects will also perform","text_display":" prior to subjects receiving their next cycle of chemotherapy. Subjects will also perform","confidence":1,"confidence_rate":1},{"cnt":[[339,730],[1858,730],[1858,780],[339,780]],"region":{"top_left_x":339,"top_left_y":730,"width":1520,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24a00c464f65497688433d46aeabe9a5","type":"text","conversion_output":true,"text":"their own alopecia assessment and be asked about wig and scarf use after each cycle using","text_display":" their own alopecia assessment and be asked about wig and scarf use after each cycle using","confidence":1,"confidence_rate":1},{"cnt":[[339,778],[1450,778],[1450,829],[339,829]],"region":{"top_left_x":339,"top_left_y":777,"width":1112,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4da8cd86c6a54c39a3591f1348c6ff65","type":"text","conversion_output":true,"text":"the CTCAE v4.0 and the alopecia pictorial tool (see Appendix B).","text_display":" the CTCAE v4.0 and the alopecia pictorial tool (see Appendix B).","confidence":1,"confidence_rate":1},{"cnt":[[339,846],[1846,846],[1846,898],[339,898]],"region":{"top_left_x":339,"top_left_y":846,"width":1507,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f52f51007daf45e990b82527cdddd96a","type":"text","conversion_output":true,"text":"Photographs of the heads of the first 25 subjects' enrolled from each site who complete at","text_display":"\nPhotographs of the heads of the first 25 subjects' enrolled from each site who complete at","confidence":1,"confidence_rate":1},{"cnt":[[339,896],[1837,896],[1837,947],[339,947]],"region":{"top_left_x":339,"top_left_y":895,"width":1498,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3407bf9d0094f7da62500d5b45be6a2","type":"text","conversion_output":true,"text":"least 1 cycle of chemotherapy will be taken at each alopecia assessment (until the subject","text_display":" least 1 cycle of chemotherapy will be taken at each alopecia assessment (until the subject","confidence":1,"confidence_rate":1},{"cnt":[[339,941],[1878,941],[1878,993],[339,993]],"region":{"top_left_x":339,"top_left_y":941,"width":1539,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cdd29731c994d8195ad7e1b9d4ad702","type":"text","conversion_output":true,"text":"develops grade 2 alopecia), and these photographs will be included in the final study report.","text_display":" develops grade 2 alopecia), and these photographs will be included in the final study report.","confidence":1,"confidence_rate":1},{"cnt":[[339,993],[1813,993],[1813,1042],[339,1042]],"region":{"top_left_x":339,"top_left_y":992,"width":1475,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d93645c9357142aea1800ad5a36e7a76","type":"text","conversion_output":true,"text":"For subjects enrolled after these 25 subjects, photographs will only be taken at baseline,","text_display":" For subjects enrolled after these 25 subjects, photographs will only be taken at baseline,","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[339,1040],[1861,1040],[1861,1089],[339,1089]],"region":{"top_left_x":339,"top_left_y":1039,"width":1522,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c6d918747944bc1872be3b0f5dab473","type":"text","conversion_output":true,"text":"after 4 cycles, and after completion of chemotherapy (if receiving more than 4 cycles). If a","text_display":" after 4 cycles, and after completion of chemotherapy (if receiving more than 4 cycles). If a","confidence":1,"confidence_rate":1},{"cnt":[[339,1087],[1807,1087],[1807,1137],[339,1137]],"region":{"top_left_x":339,"top_left_y":1087,"width":1468,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ebe9dcb09dd4b64b50aef6092ca8b60","type":"text","conversion_output":true,"text":"subject develops grade 2 alopecia at a visit prior to the post-Cycle 4 or post-completion","text_display":" subject develops grade 2 alopecia at a visit prior to the post-Cycle 4 or post-completion","confidence":1,"confidence_rate":1},{"cnt":[[339,1134],[1833,1134],[1833,1188],[339,1188]],"region":{"top_left_x":339,"top_left_y":1134,"width":1494,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16393ef88b184fdebd212ac4d099998e","type":"text","conversion_output":true,"text":"visit, photographs should be taken at the visit and do not need to be taken from that point","text_display":" visit, photographs should be taken at the visit and do not need to be taken from that point","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[339,1182],[492,1182],[492,1227],[339,1227]],"region":{"top_left_x":339,"top_left_y":1181,"width":153,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b98092804b494d8fb56e70bc7af24f41","type":"text","conversion_output":true,"text":"forward.","text_display":" forward.","confidence":1,"confidence_rate":1},{"cnt":[[339,1250],[1846,1250],[1846,1302],[339,1302]],"region":{"top_left_x":339,"top_left_y":1250,"width":1507,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0868b8a6c57f4e2bb12493a30fb361e6","type":"text","conversion_output":true,"text":"These photographs will be taken with a digital camera or camera phone in a well-lit exam","text_display":"\n\nThese photographs will be taken with a digital camera or camera phone in a well-lit exam","confidence":0.96142578125,"confidence_rate":0.9995771011940128},{"cnt":[[339,1300],[1835,1300],[1835,1351],[339,1351]],"region":{"top_left_x":339,"top_left_y":1299,"width":1496,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bd73b319c15494888297f8518128b55","type":"text","conversion_output":true,"text":"room with the subject sitting and the photographer standing. There will be 5 photographs","text_display":" room with the subject sitting and the photographer standing. There will be 5 photographs","confidence":1,"confidence_rate":1},{"cnt":[[339,1349],[1841,1349],[1841,1399],[339,1399]],"region":{"top_left_x":339,"top_left_y":1349,"width":1503,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9694490f3b4d49388ae14aeb03f29b99","type":"text","conversion_output":true,"text":"taken which will include the following views: front hairline taken 8-12\" from the subject,","text_display":" taken which will include the following views: front hairline taken 8-12\" from the subject,","confidence":0.63330078125,"confidence_rate":0.99520301821459},{"cnt":[[339,1396],[1841,1396],[1841,1446],[339,1446]],"region":{"top_left_x":339,"top_left_y":1396,"width":1503,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60cb50ccfdea413b92554a9e91d697df","type":"text","conversion_output":true,"text":"right side and left side taken 15-25\" from the subject, back of the head taken 15-25\" 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refer to bathing, dressing and undressing, feeding self, using the toilet, taking medications, and not bedridden.","text_display":"\n**Self care ADL refer to bathing, dressing and undressing, feeding self, using the toilet, taking medications, and not bedridden.","confidence":1,"confidence_rate":1},{"cnt":[[370,1332],[1807,1332],[1807,1381],[370,1381]],"region":{"top_left_x":369,"top_left_y":1332,"width":1438,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c02cdc1970e4d9ab6e3b68b02477256","type":"text","conversion_output":true,"text":"The relationship of the adverse event to the device which is the subject of this clinical","text_display":"\nThe relationship of the adverse event to the device which is the subject of this clinical","confidence":1,"confidence_rate":1},{"cnt":[[370,1381],[1195,1381],[1195,1429],[370,1429]],"region":{"top_left_x":369,"top_left_y":1381,"width":826,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"709f752a9f43434c8b99726d9cf190eb","type":"text","conversion_output":true,"text":"investigation will be graded as shown in Table 3.","text_display":" investigation will be graded as shown in Table 3.","confidence":1,"confidence_rate":1},{"cnt":[[793,1470],[1429,1470],[1429,1532],[793,1532]],"region":{"top_left_x":792,"top_left_y":1469,"width":637,"height":63},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"724320d45f3e47c1b8ae1417b93aad7d","type":"figure_label","conversion_output":false,"text":"Table 3: Expectedness \\& Attribution","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[941,1564],[1182,1564],[1182,1618],[941,1618]],"region":{"top_left_x":941,"top_left_y":1564,"width":241,"height":54},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2989b8eefa3b4c4d8c371ec6bc5529b4","type":"text","conversion_output":true,"text":"Expectedness","text_display":"\n\nExpectedness","confidence":1,"confidence_rate":1},{"cnt":[[223,1616],[1901,1616],[1901,2065],[223,2065]],"region":{"top_left_x":223,"top_left_y":1615,"width":1679,"height":450},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21e2537799624f86ab561055ded36221","type":"table","conversion_output":true,"children_ids":["9346f1c5e4f54cc9ba59475f71dc4b87","e9774718d6b145e8a712da504439bd90","e80b904e218e4d3dbe31a33f8736ba79","9e6617dfc8ce43d6adfb2e1b9fc34361","4b7741b302d440dfab66a985843bdfc4","529623929b8144528f15d1e4946508da","3c53d1ad3fbb4c2b8ddb8ca0dc4714a6","8f49dc24e7f44568ae5fda9fd41b2f31"],"selected_labels":["724320d45f3e47c1b8ae1417b93aad7d"],"text":"\\begin{tabular}{|l|l|}\n\\hline Expected & Expected adverse events are those that have been previously identified as resulting from administration of the agent. For the purposes of this study, an adverse event is considered expected when it appears in the current adverse event list, the Investigator's Brochure, the package insert or is included in the informed consent document as a potential risk. \\\\\n\\hline Unexpected & An adverse event is considered unexpected when it varies in nature, intensity or frequency from information provided in the current adverse event list, the Investigator's Brochure, the package insert or when it is not included in the informed consent document as a potential risk. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3: Expectedness \\& Attribution}\n\\begin{tabular}{|l|l|}\n\\hline Expected & Expected adverse events are those that have been previously identified as resulting from administration of the agent. For the purposes of this study, an adverse event is considered expected when it appears in the current adverse event list, the Investigator's Brochure, the package insert or is included in the informed consent document as a potential risk. \\\\\n\\hline Unexpected & An adverse event is considered unexpected when it varies in nature, intensity or frequency from information provided in the current adverse event list, the Investigator's Brochure, the package insert or when it is not included in the informed consent document as a potential risk. \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.9912109375,"confidence_rate":0.9999946682554199},{"cnt":[[239,1615],[458,1615],[458,2065],[239,2065]],"region":{"top_left_x":239,"top_left_y":1615,"width":219,"height":451},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9346f1c5e4f54cc9ba59475f71dc4b87","type":"table_column","conversion_output":false,"parent_id":"21e2537799624f86ab561055ded36221","text":"","text_display":""},{"cnt":[[488,1615],[1890,1615],[1890,2065],[488,2065]],"region":{"top_left_x":487,"top_left_y":1615,"width":1404,"height":451},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9774718d6b145e8a712da504439bd90","type":"table_column","conversion_output":false,"parent_id":"21e2537799624f86ab561055ded36221","text":"","text_display":""},{"cnt":[[223,1620],[1898,1620],[1898,1869],[223,1869]],"region":{"top_left_x":223,"top_left_y":1620,"width":1676,"height":249},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e80b904e218e4d3dbe31a33f8736ba79","type":"table_row","conversion_output":false,"parent_id":"21e2537799624f86ab561055ded36221","text":"","text_display":""},{"cnt":[[223,1863],[1901,1863],[1901,2065],[223,2065]],"region":{"top_left_x":223,"top_left_y":1863,"width":1678,"height":203},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6617dfc8ce43d6adfb2e1b9fc34361","type":"table_row","conversion_output":false,"parent_id":"21e2537799624f86ab561055ded36221","text":"","text_display":""},{"cnt":[[248,1626],[411,1626],[411,1675],[248,1675]],"region":{"top_left_x":247,"top_left_y":1625,"width":165,"height":51},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b7741b302d440dfab66a985843bdfc4","type":"simple_cell","conversion_output":false,"parent_id":"21e2537799624f86ab561055ded36221","text":"Expected","text_display":"Expected","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[493,1623],[1885,1623],[1885,1869],[493,1869]],"region":{"top_left_x":493,"top_left_y":1623,"width":1392,"height":246},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"529623929b8144528f15d1e4946508da","type":"complex_cell","conversion_output":false,"parent_id":"21e2537799624f86ab561055ded36221","children_ids":["97f68e3acd384486b743b7b58e768a6e","1b4add37c6a54da294aa08a1475ebd63","cbdbc1ac89994fe3a89b9a3d0d4c30b1","ad537dc318294ff88dd372be693ff5eb","abcb9069619a4bfebfc1d38b5174b754"],"text":"Expected adverse events are those that have been previously identified as resulting from administration of the agent. For the purposes of this study, an adverse event is considered expected when it appears in the current adverse event list, the Investigator's Brochure, the package insert or is included in the informed consent document as a potential risk.","text_display":"Expected adverse events are those that have been previously identified as resulting from administration of the agent. For the purposes of this study, an adverse event is considered expected when it appears in the current adverse event list, the Investigator's Brochure, the package insert or is included in the informed consent document as a potential risk.","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9912109375,"confidence_rate":0.9999801621875055},{"cnt":[[499,1626],[1879,1626],[1879,1675],[499,1675]],"region":{"top_left_x":498,"top_left_y":1625,"width":1382,"height":51},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97f68e3acd384486b743b7b58e768a6e","type":"text","conversion_output":false,"parent_id":"529623929b8144528f15d1e4946508da","text":"Expected adverse events are those that have been previously identified as","text_display":"Expected adverse events are those that have been previously identified as","confidence":1,"confidence_rate":1},{"cnt":[[499,1675],[1876,1675],[1876,1721],[499,1721]],"region":{"top_left_x":498,"top_left_y":1675,"width":1379,"height":47},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b4add37c6a54da294aa08a1475ebd63","type":"text","conversion_output":false,"parent_id":"529623929b8144528f15d1e4946508da","text":"resulting from administration of the agent. For the purposes of this study, an","text_display":" resulting from administration of the agent. For the purposes of this study, an","confidence":1,"confidence_rate":1},{"cnt":[[499,1721],[1879,1721],[1879,1771],[499,1771]],"region":{"top_left_x":498,"top_left_y":1721,"width":1382,"height":50},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbdbc1ac89994fe3a89b9a3d0d4c30b1","type":"text","conversion_output":false,"parent_id":"529623929b8144528f15d1e4946508da","text":"adverse event is considered expected when it appears in the current adverse event","text_display":" adverse event is considered expected when it appears in the current adverse event","confidence":1,"confidence_rate":1},{"cnt":[[499,1771],[1879,1771],[1879,1820],[499,1820]],"region":{"top_left_x":498,"top_left_y":1770,"width":1382,"height":50},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad537dc318294ff88dd372be693ff5eb","type":"text","conversion_output":false,"parent_id":"529623929b8144528f15d1e4946508da","text":"list, the Investigator's 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adverse event is considered unexpected when it varies in nature, intensity or frequency from information provided in the current adverse event list, the Investigator's Brochure, the package insert or when it is not included in the informed consent document as a potential risk.","text_display":"An adverse event is considered unexpected when it varies in nature, intensity or frequency from information provided in the current adverse event list, the Investigator's Brochure, the package insert or when it is not included in the informed consent document as a potential 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or","confidence":1,"confidence_rate":1},{"cnt":[[499,1915],[1732,1915],[1732,1967],[499,1967]],"region":{"top_left_x":498,"top_left_y":1915,"width":1234,"height":52},"line":59,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"503356df6e2d478491416c6e23935ec4","type":"text","conversion_output":false,"parent_id":"8f49dc24e7f44568ae5fda9fd41b2f31","text":"frequency from information provided in the current adverse event list, the","text_display":" frequency from information provided in the current adverse event list, the","confidence":1,"confidence_rate":1},{"cnt":[[499,1964],[1765,1964],[1765,2013],[499,2013]],"region":{"top_left_x":498,"top_left_y":1964,"width":1267,"height":50},"line":60,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"913cae856f2348d797f420f0513b0083","type":"text","conversion_output":false,"parent_id":"8f49dc24e7f44568ae5fda9fd41b2f31","text":"Investigator's Brochure, the package insert or when it is not included in the","text_display":" Investigator's Brochure, the package insert or when it is not included in the","confidence":0.99951171875,"confidence_rate":0.9999940439141021},{"cnt":[[499,2011],[1284,2011],[1284,2062],[499,2062]],"region":{"top_left_x":498,"top_left_y":2010,"width":787,"height":53},"line":61,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c996064b672410888eccfef2bf5cc9d","type":"text","conversion_output":false,"parent_id":"8f49dc24e7f44568ae5fda9fd41b2f31","text":"informed consent document as a potential risk.","text_display":" informed consent document as a potential 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is the relationship between an adverse event and the study treatment.","text_display":"\n\nAttribution is the relationship between an adverse event and the study treatment.","confidence":1,"confidence_rate":1},{"cnt":[[370,2299],[1033,2299],[1033,2348],[370,2348]],"region":{"top_left_x":369,"top_left_y":2298,"width":665,"height":51},"line":65,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a12ed10e35af4380a04352bef9c2b417","type":"text","conversion_output":true,"text":"Attribution will be assigned as follows:","text_display":" Attribution will be assigned as follows:","confidence":1,"confidence_rate":1},{"cnt":[[466,2389],[1734,2389],[1734,2499],[466,2499]],"region":{"top_left_x":466,"top_left_y":2389,"width":1268,"height":110},"line":66,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb54fa722b2f4ed9beb1b62de0814d6b","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|}\n\\hline Definite & The AE is clearly related to the study device \\\\\n\\hline Probable & The AE is likely related to the study device \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Definite & The AE is clearly related to the study device \\\\\n\\hline Probable & The AE is likely related to the study device \\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1091,2557],[1091,2608],[1038,2608]],"region":{"top_left_x":1037,"top_left_y":2556,"width":55,"height":53},"line":67,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3f76fd6956344bdae5f1089c24ebfa5","type":"page_info","conversion_output":false,"text":"36","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-37","page":37,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39ad4c40413040feb1fc1d5303c76178","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention 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\\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Possible & The AE may be related to the study device \\\\\n\\hline Unlikely & The AE is doubtfully related to the study device \\\\\n\\hline Unrelated & The AE is clearly NOT related to the study device \\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[236,434],[885,434],[885,501],[236,501]],"region":{"top_left_x":236,"top_left_y":433,"width":650,"height":68},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81ba1fe14fda440bb0761d4ad4d47032","type":"section_header","conversion_output":false,"children_ids":["8c62b0ba82ea42dd8e56381d9d68d7fb"],"text":"","text_display":""},{"cnt":[[243,443],[879,443],[879,496],[243,496]],"region":{"top_left_x":242,"top_left_y":442,"width":637,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c62b0ba82ea42dd8e56381d9d68d7fb","type":"text","conversion_output":true,"parent_id":"81ba1fe14fda440bb0761d4ad4d47032","text":"M.3.2 Serious Adverse Event (SAE)","text_display":"\n\n\\section*{M.3.2 Serious Adverse Event 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We expect to see very low rates ( \\(<10-15 \\%\\) ) of","text_display":"\nOur primary endpoint is hair preservation. We expect to see very low rates ( \\(<10-15 \\%\\) ) of","confidence":0.8153884182684124,"confidence_rate":0.9978981841577028},{"cnt":[[344,1010],[1876,1010],[1876,1059],[344,1059]],"region":{"top_left_x":343,"top_left_y":1009,"width":1533,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b98679e1716a47d8a9dc9376898daa2b","type":"text","conversion_output":true,"text":"hair preservation in the control group, and propose to use a 2 to 1 randomization in order to","text_display":" hair preservation in the control group, and propose to use a 2 to 1 randomization in order to","confidence":1,"confidence_rate":1},{"cnt":[[344,1057],[1785,1057],[1785,1106],[344,1106]],"region":{"top_left_x":343,"top_left_y":1057,"width":1443,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a1c0c037272410b8be6307293bc22e7","type":"text","conversion_output":true,"text":"gain additional experience with the experimental arm, and to make participation more","text_display":" gain additional experience with the experimental arm, and to make participation more","confidence":1,"confidence_rate":1},{"cnt":[[344,1104],[1824,1104],[1824,1154],[344,1154]],"region":{"top_left_x":343,"top_left_y":1104,"width":1482,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"085197556f454510aaae7b5d6e5d2fe9","type":"text","conversion_output":true,"text":"attractive. An absolute difference of \\(20 \\%\\) (i.e. \\(15 \\%\\) vs. \\(35 \\%\\) ) will be deemed a clinically","text_display":" attractive. An absolute difference of \\(20 \\%\\) (i.e. \\(15 \\%\\) vs. \\(35 \\%\\) ) will be deemed a clinically","confidence":0.5489009281897839,"confidence_rate":0.9941932614288},{"cnt":[[344,1152],[1815,1152],[1815,1205],[344,1205]],"region":{"top_left_x":343,"top_left_y":1151,"width":1473,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68225398eeb844a99d0c79ba3edc5e54","type":"text","conversion_output":true,"text":"meaningful difference. A total sample size of 213 response evaluable study participants","text_display":" meaningful difference. A total sample size of 213 response evaluable study participants","confidence":1,"confidence_rate":1},{"cnt":[[344,1199],[1790,1199],[1790,1250],[344,1250]],"region":{"top_left_x":343,"top_left_y":1198,"width":1447,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ca82c68c2674c0492fc25f2a07cbd7b","type":"text","conversion_output":true,"text":"will provide \\(85 \\%\\) power to detect a difference in preservation of \\(20 \\%\\) between control","text_display":" will provide \\(85 \\%\\) power to detect a difference in preservation of \\(20 \\%\\) between control","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[344,1248],[1783,1248],[1783,1300],[344,1300]],"region":{"top_left_x":343,"top_left_y":1248,"width":1441,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68b6d2d8a4a34f5fb7760ef81dac6f47","type":"text","conversion_output":true,"text":"( \\(15 \\%\\) ) and Paxman ( \\(35 \\%\\) ) at the \\(5 \\%\\) level of significance. If, as we expect, the rate of","text_display":" ( \\(15 \\%\\) ) and Paxman ( \\(35 \\%\\) ) at the \\(5 \\%\\) level of significance. If, as we expect, the rate of","confidence":0.9960982785560191,"confidence_rate":0.9999620458366231},{"cnt":[[344,1296],[1837,1296],[1837,1347],[344,1347]],"region":{"top_left_x":343,"top_left_y":1295,"width":1494,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3068355f7a7e47feb7c97c38c9a5ca88","type":"text","conversion_output":true,"text":"preservation will be lower than \\(15 \\%\\) in the control group, then the power to detect a \\(20 \\%\\)","text_display":" preservation will be lower than \\(15 \\%\\) in the control group, then the power to detect a \\(20 \\%\\)","confidence":0.9956073760986328,"confidence_rate":0.9999536610755838},{"cnt":[[344,1345],[995,1345],[995,1394],[344,1394]],"region":{"top_left_x":343,"top_left_y":1344,"width":652,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f93f91d5873b49c89d2e76ca2ff2831c","type":"text","conversion_output":true,"text":"improvement will be higher (Table 2).","text_display":" improvement will be higher (Table 2).","confidence":1,"confidence_rate":1},{"cnt":[[584,1439],[1665,1439],[1665,1485],[584,1485]],"region":{"top_left_x":584,"top_left_y":1439,"width":1082,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83d901c69c754ff89be6d4770b6d9116","type":"figure_label","conversion_output":false,"text":"Table 2 - Power to detect differences under difference scenarios","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[571,1482],[1555,1482],[1555,1989],[571,1989]],"region":{"top_left_x":571,"top_left_y":1482,"width":985,"height":508},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b31750b990c44efa25cdb57ec22b074","type":"table","conversion_output":true,"selected_labels":["83d901c69c754ff89be6d4770b6d9116"],"text":"\\begin{tabular}{|r|c|c|}\n\\hline & Scenario 1 & Scenario 2 \\\\\n\\hline Level of Significance & \\(5 \\%\\) & \\(5 \\%\\) \\\\\n\\hline Proportion Alopecia Grade <2 & & \\\\\n\\hline Control & 0.15 & 0.10 \\\\\n\\hline Paxman Scalp Cooling & 0.35 & 0.30 \\\\\n\\hline Odds Ratio & 3.05 & 3.86 \\\\\n\\hline Power & 0.85 & 0.90 \\\\\n\\hline N control & 71 & 71 \\\\\n\\hline Total N N Paxman & 142 & 142 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2 - Power to detect differences under difference scenarios}\n\\begin{tabular}{|r|c|c|}\n\\hline & Scenario 1 & Scenario 2 \\\\\n\\hline Level of Significance & \\(5 \\%\\) & \\(5 \\%\\) \\\\\n\\hline Proportion Alopecia Grade <2 & & \\\\\n\\hline Control & 0.15 & 0.10 \\\\\n\\hline Paxman Scalp Cooling & 0.35 & 0.30 \\\\\n\\hline Odds Ratio & 3.05 & 3.86 \\\\\n\\hline Power & 0.85 & 0.90 \\\\\n\\hline N control & 71 & 71 \\\\\n\\hline Total N N Paxman & 142 & 142 \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.6921523057738042,"confidence_rate":0.9989055123279112},{"cnt":[[339,2032],[1755,2032],[1755,2084],[339,2084]],"region":{"top_left_x":339,"top_left_y":2032,"width":1417,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46d92030c7914e77aa9a87c8eb46b8e6","type":"text","conversion_output":true,"text":"The study will require 213 response evaluable subjects and \\(\\sim 325\\) consented patients.","text_display":"\n\nThe study will require 213 response evaluable subjects and \\(\\sim 325\\) consented patients.","confidence":1,"confidence_rate":1},{"cnt":[[339,2082],[1876,2082],[1876,2133],[339,2133]],"region":{"top_left_x":339,"top_left_y":2081,"width":1537,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c943a0becdd7428ab9c29c195f4eacc9","type":"text","conversion_output":true,"text":"Considering a \\(22 \\%\\) drop-out rate, we expect to accrue 273 subjects so that we will have 213","text_display":" Considering a \\(22 \\%\\) drop-out rate, we expect to accrue 273 subjects so that we will have 213","confidence":1,"confidence_rate":1},{"cnt":[[337,2127],[1820,2127],[1820,2181],[337,2181]],"region":{"top_left_x":337,"top_left_y":2126,"width":1483,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc87eb06a4b64cc6a7a79810f141f958","type":"text","conversion_output":true,"text":"evaluable subjects at the final analysis. If we also consider a \\(16 \\%\\) screen failure, we will","text_display":" evaluable subjects at the final analysis. If we also consider a \\(16 \\%\\) screen failure, we will","confidence":1,"confidence_rate":1},{"cnt":[[337,2179],[1068,2179],[1068,2228],[337,2228]],"region":{"top_left_x":337,"top_left_y":2178,"width":731,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"316d2863360c4352bcb688f940108b91","type":"text","conversion_output":true,"text":"need to consent 325 subjects for this study.","text_display":" need to consent 325 subjects for this study.","confidence":0.99951171875,"confidence_rate":0.9999906077268363},{"cnt":[[357,2264],[804,2264],[804,2331],[357,2331]],"region":{"top_left_x":356,"top_left_y":2264,"width":448,"height":68},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f10de36113f44d84ae1281e8d4606e26","type":"section_header","conversion_output":false,"children_ids":["ec0dc22090c944d7b36c9c88e4d37482"],"text":"","text_display":""},{"cnt":[[363,2269],[797,2269],[797,2327],[363,2327]],"region":{"top_left_x":363,"top_left_y":2268,"width":435,"height":59},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec0dc22090c944d7b36c9c88e4d37482","type":"text","conversion_output":true,"parent_id":"f10de36113f44d84ae1281e8d4606e26","text":"P. 3 Interim Analysis","text_display":"\n\n\\section*{P. 3 Interim Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[344,2342],[1865,2342],[1865,2396],[344,2396]],"region":{"top_left_x":343,"top_left_y":2341,"width":1522,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1735435ce1a84d1ca8e12239e23458a0","type":"text","conversion_output":true,"text":"One interim analysis will take place about two-thirds of the way through the study after 95","text_display":"\n\nOne interim analysis will take place about two-thirds of the way through the study after 95","confidence":0.9990234375,"confidence_rate":0.9999897154250147},{"cnt":[[344,2391],[1803,2391],[1803,2443],[344,2443]],"region":{"top_left_x":343,"top_left_y":2391,"width":1460,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62ea93427bc547ca83daee779f16ca41","type":"text","conversion_output":true,"text":"patients are enrolled to the cooling group and 47 patients are enrolled to the no cooling","text_display":" patients are enrolled to the cooling group and 47 patients are enrolled to the no cooling","confidence":1,"confidence_rate":1},{"cnt":[[344,2436],[1755,2436],[1755,2490],[344,2490]],"region":{"top_left_x":343,"top_left_y":2436,"width":1413,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2484e60a0f4245c8a32e4bf0035e6233","type":"text","conversion_output":true,"text":"group and have been evaluated for the primary endpoint. The purpose of the interim","text_display":" group and have been evaluated for the primary endpoint. The purpose of the interim","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2610],[1038,2610]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36166c81590e4061b5b2382cdc6c4d2a","type":"page_info","conversion_output":false,"text":"50","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-51","page":51,"lines":[{"cnt":[[245,99],[1257,99],[1257,144],[245,144]],"region":{"top_left_x":244,"top_left_y":98,"width":1013,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fae3a3447904c05ae0b5d604c290004","type":"page_info","conversion_output":false,"text":"Clinical Investigation Plan: Orbis Paxman Hair Loss Prevention System","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,142],[900,142],[900,183],[245,183]],"region":{"top_left_x":244,"top_left_y":141,"width":657,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"013994fdd18345789c5457433d4f1df5","type":"page_info","conversion_output":false,"text":"Protocol \\#H-33692, Revision 10 (01JUL2016)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[344,251],[1760,251],[1760,303],[344,303]],"region":{"top_left_x":343,"top_left_y":251,"width":1417,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75eecee4470c43c78b1150d25c0af0b4","type":"text","conversion_output":true,"text":"analysis is to allow the study to stop early for efficacy (superiority). To maintain the","text_display":"\nanalysis is to allow the study to stop early for efficacy (superiority). To maintain the","confidence":1,"confidence_rate":1},{"cnt":[[344,301],[1861,301],[1861,350],[344,350]],"region":{"top_left_x":343,"top_left_y":300,"width":1518,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdbcc36159ec4c4e87019da8b11d6ae7","type":"text","conversion_output":true,"text":"overall type 1 error rate, an O'Brien-Fleming spending function has been used to calculate","text_display":" overall type 1 error rate, an O'Brien-Fleming spending function has been used to calculate","confidence":1,"confidence_rate":1},{"cnt":[[344,348],[1880,348],[1880,397],[344,397]],"region":{"top_left_x":343,"top_left_y":348,"width":1537,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"664cc14494c0406787c537d36b0617a1","type":"text","conversion_output":true,"text":"the superiority boundary. Calculations were performed using nQuery Advisor + nTerim 3.0","text_display":" the superiority boundary. Calculations were performed using nQuery Advisor + nTerim 3.0","confidence":0.728668212890625,"confidence_rate":0.9965276165956685},{"cnt":[[346,395],[947,395],[947,445],[346,445]],"region":{"top_left_x":345,"top_left_y":395,"width":603,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"020b037aa7f64cbeb90eb31fe5ed7fa8","type":"text","conversion_output":true,"text":"(Statistical Solutions. Boston, MA).","text_display":" (Statistical Solutions. Boston, MA).","confidence":1,"confidence_rate":1},{"cnt":[[344,464],[1876,464],[1876,513],[344,513]],"region":{"top_left_x":343,"top_left_y":464,"width":1533,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"854e005c7c404e348b15b3b11340affb","type":"text","conversion_output":true,"text":"The following table summarizes the superiority boundary at each of 2 looks when \\(66 \\%\\) and","text_display":"\n\nThe following table summarizes the superiority boundary at each of 2 looks when \\(66 \\%\\) and","confidence":0.9951171875,"confidence_rate":0.9999500545904081},{"cnt":[[346,511],[1867,511],[1867,563],[346,563]],"region":{"top_left_x":345,"top_left_y":511,"width":1522,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15a8684d8a9d4ac48f60f66c8483def4","type":"text","conversion_output":true,"text":"\\(100 \\%\\) patients are enrolled and evaluated, respectively. The superiority boundary on the p-","text_display":" \\(100 \\%\\) patients are enrolled and evaluated, respectively. The superiority boundary on the p","confidence":1,"confidence_rate":1},{"cnt":[[346,561],[1863,561],[1863,610],[346,610]],"region":{"top_left_x":345,"top_left_y":560,"width":1518,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b15a953ff1e84b57b3bfac39f7eaed92","type":"text","conversion_output":true,"text":"value scale at the interim analysis is calculated as \\(p =0.0061\\) (or \\(Z =2.509\\) ). If the one-tailed","text_display":"value scale at the interim analysis is calculated as \\(p =0.0061\\) (or \\(Z =2.509\\) ). If the one-tailed","confidence":0.998046875,"confidence_rate":0.999982387228658},{"cnt":[[344,608],[1833,608],[1833,660],[344,660]],"region":{"top_left_x":343,"top_left_y":608,"width":1490,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5a206ead26b474e9f2ad40235a3176b","type":"text","conversion_output":true,"text":"p -value from a Fisher's exact test is less than or equal to 0.0061 , it will be recommended","text_display":" p -value from a Fisher's exact test is less than or equal to 0.0061 , it will be recommended","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[344,657],[849,657],[849,707],[344,707]],"region":{"top_left_x":343,"top_left_y":657,"width":506,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7b27d1ebbdb46389b1070227f9c657c","type":"text","conversion_output":true,"text":"that the trial stop for efficacy.","text_display":" that the trial stop for efficacy.","confidence":1,"confidence_rate":1},{"cnt":[[331,765],[1953,765],[1953,1072],[331,1072]],"region":{"top_left_x":330,"top_left_y":764,"width":1623,"height":309},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce53e9978e144ac8845c1b737bc772ad","type":"table","conversion_output":true,"text":"\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline Looks & \\begin{tabular}{c} \nAccumulated \\\\\n'Information'\n\\end{tabular} & \\begin{tabular}{c} \nEvaluable N \\\\\n(cooling \\\\\ngroup)\n\\end{tabular} & \\begin{tabular}{c} \nEvaluable N \\\\\n(no cooling \\\\\ngroup)\n\\end{tabular} & \\begin{tabular}{c} \nSuperiority \\\\\nBoundary \\\\\n(Z value) \\({ }^{1}\\)\n\\end{tabular} & \\begin{tabular}{c} \nSuperiority \\\\\nBoundary \\\\\n(One-tailed \\\\\np-value)\n\\end{tabular} \\\\\n\\hline 1 & \\(66 \\%\\) & 95 & 47 & 2.509 & 0.0061 \\\\\n\\hline 2 & \\(100 \\%\\) & 142 & 71 & 1.993 & 0.0231 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline Looks & \\begin{tabular}{c} \nAccumulated \\\\\n'Information'\n\\end{tabular} & \\begin{tabular}{c} \nEvaluable N \\\\\n(cooling \\\\\ngroup)\n\\end{tabular} & \\begin{tabular}{c} \nEvaluable N \\\\\n(no cooling \\\\\ngroup)\n\\end{tabular} & \\begin{tabular}{c} \nSuperiority \\\\\nBoundary \\\\\n(Z value) \\({ }^{1}\\)\n\\end{tabular} & \\begin{tabular}{c} \nSuperiority \\\\\nBoundary \\\\\n(One-tailed \\\\\np-value)\n\\end{tabular} \\\\\n\\hline 1 & \\(66 \\%\\) & 95 & 47 & 2.509 & 0.0061 \\\\\n\\hline 2 & \\(100 \\%\\) & 142 & 71 & 1.993 & 0.0231 \\\\\n\\hline\n\\end{tabular}","confidence":0.6601153685341747,"confidence_rate":0.9990068555558881},{"cnt":[[339,1070],[1837,1070],[1837,1111],[339,1111]],"region":{"top_left_x":339,"top_left_y":1069,"width":1498,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2422ac296bd2465086300a5666c43d5d","type":"text","conversion_output":true,"text":"1. For the software, Z -value boundaries are specified assuming that a Z test for proportions (unpooled variance) will be","text_display":"\n1. For the software, Z -value boundaries are specified assuming that a Z test for proportions (unpooled variance) will be","confidence":0.9951212396845222,"confidence_rate":0.9999645607706122},{"cnt":[[370,1104],[1807,1104],[1807,1145],[370,1145]],"region":{"top_left_x":369,"top_left_y":1104,"width":1438,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d0771aafc9d447b9d88a606de203c20","type":"text","conversion_output":true,"text":"used, however the corresponding \\(p\\)-values apply equally well to Fisher's exact test, which was used in the original","text_display":" used, however the corresponding \\(p\\)-values apply equally well to Fisher's exact test, which was used in the original","confidence":0.693068265914917,"confidence_rate":0.9970237323895184},{"cnt":[[370,1141],[1154,1141],[1154,1179],[370,1179]],"region":{"top_left_x":369,"top_left_y":1140,"width":785,"height":40},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bef3029b0149431aa0df4f7851f2be62","type":"text","conversion_output":true,"text":"sample size calculations, and is still proposed for the analysis.","text_display":" sample size calculations, and is still proposed for the analysis.","confidence":1,"confidence_rate":1},{"cnt":[[350,1220],[874,1220],[874,1276],[350,1276]],"region":{"top_left_x":350,"top_left_y":1220,"width":525,"height":57},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f618009f0ba49dab0a39fb2959258be","type":"section_header","conversion_output":false,"children_ids":["b32cfba633e74294a3d51b2ca39cab8a"],"text":"","text_display":""},{"cnt":[[357,1225],[870,1225],[870,1274],[357,1274]],"region":{"top_left_x":356,"top_left_y":1224,"width":515,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b32cfba633e74294a3d51b2ca39cab8a","type":"text","conversion_output":true,"parent_id":"7f618009f0ba49dab0a39fb2959258be","text":"P. 4 Stratification Factors","text_display":"\n\n\\section*{P. 4 Stratification 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A table of baseline subjects'","text_display":" all subjects enrolled in each treatment group at each center. A table of baseline subjects'","confidence":1,"confidence_rate":1},{"cnt":[[346,1652],[1811,1652],[1811,1704],[346,1704]],"region":{"top_left_x":345,"top_left_y":1652,"width":1467,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"590f9a6e9d5144478cb5718cbf4288c0","type":"text","conversion_output":true,"text":"demographic and clinical data, grouped by major chemotherapy type and center will be","text_display":" demographic and clinical data, grouped by major chemotherapy type and center will be","confidence":1,"confidence_rate":1},{"cnt":[[344,1702],[1824,1702],[1824,1751],[344,1751]],"region":{"top_left_x":343,"top_left_y":1701,"width":1482,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36dfaf0b7cc645fd9f484b20e1f1b297","type":"text","conversion_output":true,"text":"reported. Since randomization will be stratified by major chemotherapy type and center,","text_display":" reported. Since randomization will be stratified by major chemotherapy type and center,","confidence":1,"confidence_rate":1},{"cnt":[[346,1749],[1824,1749],[1824,1798],[346,1798]],"region":{"top_left_x":345,"top_left_y":1748,"width":1480,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8615e29c857b4c74a974e7c8a9d7c882","type":"text","conversion_output":true,"text":"each center will contribute the same number of subjects to each treatment group. A non-","text_display":" each center will contribute the same number of subjects to each treatment group. A non","confidence":1,"confidence_rate":1},{"cnt":[[344,1796],[1863,1796],[1863,1846],[344,1846]],"region":{"top_left_x":343,"top_left_y":1796,"width":1520,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cc3c219a25d44638569feee21bb825e","type":"text","conversion_output":true,"text":"significant test for interaction between the treatment effect and center will be performed to","text_display":"significant test for interaction between the treatment effect and center will be performed to","confidence":1,"confidence_rate":1},{"cnt":[[344,1843],[1828,1843],[1828,1893],[344,1893]],"region":{"top_left_x":343,"top_left_y":1843,"width":1486,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a003b7508174764a2ebc4f8f4cdfb7e","type":"text","conversion_output":true,"text":"confirm the consistency of the treatment effect. Summary table will also be provided for","text_display":" confirm the consistency of the treatment effect. Summary table will also be provided for","confidence":1,"confidence_rate":1},{"cnt":[[344,1893],[1772,1893],[1772,1944],[344,1944]],"region":{"top_left_x":343,"top_left_y":1892,"width":1430,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67bca6db15274f429bda704f9ad1c68f","type":"text","conversion_output":true,"text":"the status of the protocol treatment such as the number of subjects who stop the scalp","text_display":" the status of the protocol treatment such as the number of subjects who stop the scalp","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[344,1942],[1055,1942],[1055,1992],[344,1992]],"region":{"top_left_x":343,"top_left_y":1942,"width":712,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55d7cb0e4707478b973dc0010521e912","type":"text","conversion_output":true,"text":"cooling earlier and the reason of stopping.","text_display":" cooling earlier and the reason of stopping.","confidence":1,"confidence_rate":1},{"cnt":[[344,2007],[1865,2007],[1865,2058],[344,2058]],"region":{"top_left_x":343,"top_left_y":2006,"width":1522,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3150656fb38455886690a2839888cb1","type":"text","conversion_output":true,"text":"The primary efficacy analysis will be based on the intent to treat (ITT) population, defined","text_display":"\nThe primary efficacy analysis will be based on the intent to treat (ITT) population, defined","confidence":1,"confidence_rate":1},{"cnt":[[344,2056],[1850,2056],[1850,2108],[344,2108]],"region":{"top_left_x":343,"top_left_y":2056,"width":1507,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ef679523ac94b8db317bef4440e7256","type":"text","conversion_output":true,"text":"as eligible and randomized subjects who undergo at least one cycle of chemotherapy. 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The","confidence":1,"confidence_rate":1},{"cnt":[[344,2105],[1807,2105],[1807,2155],[344,2155]],"region":{"top_left_x":343,"top_left_y":2105,"width":1464,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c12bc3e063d4c34adcb84fc11fe1bab","type":"text","conversion_output":true,"text":"primary efficacy endpoint will be success in hair preservation, defined as CTCAE v4.0","text_display":" primary efficacy endpoint will be success in hair preservation, defined as CTCAE v4.0","confidence":1,"confidence_rate":1},{"cnt":[[344,2153],[1796,2153],[1796,2202],[344,2202]],"region":{"top_left_x":343,"top_left_y":2152,"width":1454,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"455d960f65194e6aa3ab385d46599f17","type":"text","conversion_output":true,"text":"alopecia grade \\(<2\\), and will be assessed by a healthcare professional who is blinded to","text_display":" alopecia grade \\(<2\\), and will be assessed by a healthcare professional who is blinded to","confidence":1,"confidence_rate":1},{"cnt":[[346,2200],[1828,2200],[1828,2249],[346,2249]],"region":{"top_left_x":345,"top_left_y":2200,"width":1484,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"651891ecd8a7483da56777826bdf6499","type":"text","conversion_output":true,"text":"study treatment. The rates of hair preservation in the scalp cooling group and the control","text_display":" study treatment. The rates of hair preservation in the scalp cooling group and the control","confidence":1,"confidence_rate":1},{"cnt":[[344,2247],[1699,2247],[1699,2299],[344,2299]],"region":{"top_left_x":343,"top_left_y":2247,"width":1357,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bff2d8624504820a61258382122090b","type":"text","conversion_output":true,"text":"group will be calculated and summarized. The hypothesis testing for the primary","text_display":" group will be calculated and summarized. The hypothesis testing for the primary","confidence":1,"confidence_rate":1},{"cnt":[[344,2297],[1809,2297],[1809,2348],[344,2348]],"region":{"top_left_x":343,"top_left_y":2296,"width":1466,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bce62d28fc034b2989e39a911bde5472","type":"text","conversion_output":true,"text":"effectiveness endpoint is \\(H _{0}: p _{ t }= p _{ c }\\) [i.e., proportion of women in the treated group who","text_display":" effectiveness endpoint is \\(H _{0}: p _{ t }= p _{ c }\\) [i.e., proportion of women in the treated group who","confidence":0.936104279011488,"confidence_rate":0.9994922181993778},{"cnt":[[344,2346],[1828,2346],[1828,2396],[344,2396]],"region":{"top_left_x":343,"top_left_y":2346,"width":1486,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"988ff7ecae0d4fcdbdad22fdc4ba8a81","type":"text","conversion_output":true,"text":"have CTCAE v4.0 grade 0 or 1, equals to the proportion of women in control group who","text_display":" have CTCAE v4.0 grade 0 or 1, equals to the proportion of women in control group who","confidence":0.866562626324594,"confidence_rate":0.9984444622202691},{"cnt":[[344,2393],[1858,2393],[1858,2443],[344,2443]],"region":{"top_left_x":343,"top_left_y":2393,"width":1516,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a8bf6fb7536464b9396cde0f82ef6cf","type":"text","conversion_output":true,"text":"have CTCAE v4.0 grade 0 or 1], versus \\(H _{ a }: p _{ t } \\neq p _{ c }\\) testing for 2-sided alpha of \\(5 \\%\\) level of","text_display":" have CTCAE v4.0 grade 0 or 1], versus \\(H _{ a }: p _{ t } \\neq p _{ c }\\) testing for 2-sided alpha of \\(5 \\%\\) level of","confidence":0.4891987889176127,"confidence_rate":0.9949420097472367},{"cnt":[[344,2441],[1880,2441],[1880,2490],[344,2490]],"region":{"top_left_x":343,"top_left_y":2440,"width":1537,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aaf2bd4de17a4354ba4bc43245dd6af7","type":"text","conversion_output":true,"text":"significance. Fisher's exact test will be used to test whether there is a difference in the rates","text_display":" significance. 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The study will be deemed as success if there is a significant difference","text_display":"\nof hair preservation. The study will be deemed as success if there is a significant difference","confidence":1,"confidence_rate":1},{"cnt":[[344,301],[1790,301],[1790,350],[344,350]],"region":{"top_left_x":343,"top_left_y":300,"width":1447,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39a4989f7489442eb4fbe7d6c2522e57","type":"text","conversion_output":true,"text":"in rates of hair preservation between the scalp cooling group and the control group. P-","text_display":" in rates of hair preservation between the scalp cooling group and the control group. 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All adverse device effects, including serious adverse device effect and","text_display":" events. All adverse device effects, including serious adverse device effect and","confidence":1,"confidence_rate":1},{"cnt":[[344,539],[1871,539],[1871,591],[344,591]],"region":{"top_left_x":343,"top_left_y":539,"width":1529,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c52c9c4475c9402c9c7e0fcd668efb80","type":"text","conversion_output":true,"text":"unanticipated adverse device effect, will be described and summarized. The primary safety","text_display":" unanticipated adverse device effect, will be described and summarized. The primary safety","confidence":1,"confidence_rate":1},{"cnt":[[344,589],[1798,589],[1798,638],[344,638]],"region":{"top_left_x":343,"top_left_y":588,"width":1456,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0e2d8e43c5544b0ab2ec78651936c00","type":"text","conversion_output":true,"text":"analysis will be based on incidence rates of adverse device effects and their exact 95\\%","text_display":" analysis will be based on incidence rates of adverse device effects and their exact 95\\%","confidence":0.54296875,"confidence_rate":0.9933839017494486},{"cnt":[[344,636],[700,636],[700,681],[344,681]],"region":{"top_left_x":343,"top_left_y":635,"width":358,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f384c8ff1994909b4bb684be9148b2b","type":"text","conversion_output":true,"text":"confidence intervals.","text_display":" confidence 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N. K., S. Ahmedzai, et al. (1993). \"The European Organization for Research and","text_display":"\n\nAaronson, N. K., S. Ahmedzai, et al. (1993). \"The European Organization for Research and","confidence":1,"confidence_rate":1},{"cnt":[[370,397],[1867,397],[1867,445],[370,445]],"region":{"top_left_x":369,"top_left_y":397,"width":1498,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f0e1372c5464129979b1bf3d11905df","type":"text","conversion_output":true,"text":"Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international","text_display":" Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international","confidence":1,"confidence_rate":1},{"cnt":[[370,443],[1854,443],[1854,492],[370,492]],"region":{"top_left_x":369,"top_left_y":442,"width":1486,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15f7b0120f3143779a9dccc9e4aa3b54","type":"text","conversion_output":true,"text":"clinical trials in oncology.\" Journal of the National Cancer Institute 85(5): 365-376.","text_display":" clinical trials in oncology.\" Journal of the National Cancer Institute 85(5): 365-376.","confidence":1,"confidence_rate":1},{"cnt":[[245,490],[1841,490],[1841,539],[245,539]],"region":{"top_left_x":244,"top_left_y":489,"width":1598,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a449fa45b798476684cd836f9e37efe0","type":"text","conversion_output":true,"text":"American Cancer Society, e. a. (2011). \"What are the key statistics about breast cancer?\"","text_display":"\nAmerican Cancer Society, e. a. (2011). \"What are the key statistics about breast cancer?\"","confidence":1,"confidence_rate":1},{"cnt":[[370,541],[780,541],[780,587],[370,587]],"region":{"top_left_x":369,"top_left_y":541,"width":411,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdcbc55e794f4652a6e9fba2bfc1249f","type":"text","conversion_output":true,"text":"Retrieved 9/22/11from","text_display":" Retrieved 9/22/11from","confidence":0.9990236759185791,"confidence_rate":0.9999624314366309},{"cnt":[[370,587],[1794,587],[1794,638],[370,638]],"region":{"top_left_x":369,"top_left_y":586,"width":1425,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d02f07aad9b94777b10d8324e459cf3d","type":"text","conversion_output":true,"text":"http://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-key-","text_display":" http://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-key","confidence":1,"confidence_rate":1},{"cnt":[[370,636],[541,636],[541,683],[370,683]],"region":{"top_left_x":369,"top_left_y":635,"width":173,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c4665ec043d459c9184490f8edd144c","type":"text","conversion_output":true,"text":"statistics.","text_display":"statistics.","confidence":1,"confidence_rate":1},{"cnt":[[245,683],[1794,683],[1794,733],[245,733]],"region":{"top_left_x":244,"top_left_y":683,"width":1550,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c6027626f444870920e7b8e0a8727d4","type":"text","conversion_output":true,"text":"Benjamin, B., Ziginskas, D., Harman, J. \\& Meakin.T (2002). \"Pulsed electrostatic field","text_display":"\nBenjamin, B., Ziginskas, D., Harman, J. \\& Meakin.T (2002). \"Pulsed electrostatic field","confidence":1,"confidence_rate":1},{"cnt":[[370,730],[1863,730],[1863,780],[370,780]],"region":{"top_left_x":369,"top_left_y":730,"width":1494,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6161c38298eb4b2aa0ff80a4d40075cf","type":"text","conversion_output":true,"text":"(ETG) to reduce hair loss in women undergoing chemotherapy for breast cancer: A","text_display":" (ETG) to reduce hair loss in women undergoing chemotherapy for breast cancer: A","confidence":0.989750862121582,"confidence_rate":0.9998773644019499},{"cnt":[[370,780],[1145,780],[1145,831],[370,831]],"region":{"top_left_x":369,"top_left_y":779,"width":777,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12b0803e552f4fa387cf0f2749f59d67","type":"text","conversion_output":true,"text":"pilot study.\" Psycho-Oncology 11: 244-248.","text_display":" pilot study.\" Psycho-Oncology 11: 244-248.","confidence":1,"confidence_rate":1},{"cnt":[[245,827],[1798,827],[1798,879],[245,879]],"region":{"top_left_x":244,"top_left_y":827,"width":1555,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0faf5c8512e14e66b0679a4821c65279","type":"text","conversion_output":true,"text":"Breed, W. 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(2011). Multicenter results of scalp cooling to prevent","text_display":"\nC. van den Hurk, e. a. (2011). Multicenter results of scalp cooling to prevent","confidence":1,"confidence_rate":1},{"cnt":[[370,1113],[1880,1113],[1880,1164],[370,1164]],"region":{"top_left_x":369,"top_left_y":1112,"width":1511,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"695de4e00bf2445aad89a06d04e0f589","type":"text","conversion_output":true,"text":"chemotherapy-induced alopecia in 1500 breast cancer patients. . San Antonio Breast","text_display":" chemotherapy-induced alopecia in 1500 breast cancer patients. . 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The EORTC QLQ-C30 Scoring Manual (3rd","text_display":"\nFayers, P., N. Aaronson, et al. (2001). The EORTC QLQ-C30 Scoring Manual (3rd","confidence":1,"confidence_rate":1},{"cnt":[[370,1354],[1846,1354],[1846,1403],[370,1403]],"region":{"top_left_x":369,"top_left_y":1353,"width":1477,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"232866756f5942c697ce7ba0794450e1","type":"text","conversion_output":true,"text":"Edition). Brussels, European Organisation for Research and Treatment of Cancer.","text_display":" Edition). Brussels, European Organisation for Research and Treatment of Cancer.","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1807,1401],[1807,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1400,"width":1563,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f72865cc07c44fa6875218980a035f68","type":"text","conversion_output":true,"text":"Grevelman, E. B., WP (2005). \"Prevention of chemotherapy -induced hair loss by scalp","text_display":"\nGrevelman, E. B., WP (2005). \"Prevention of chemotherapy -induced hair loss by scalp","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[370,1452],[1018,1452],[1018,1502],[370,1502]],"region":{"top_left_x":369,"top_left_y":1452,"width":650,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f80fca1a667488d886b22534b552929","type":"text","conversion_output":true,"text":"cooling.\" Ann.Oncol 17(2): 352-358.","text_display":" cooling.\" Ann.Oncol 17(2): 352-358.","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61cbcaf9f7b6438889a269d8d7673317","type":"text","conversion_output":true,"text":"J Lemieux, e. a. (2011). Survival in women with breast cancer who used or did not use scalp","text_display":"\nJ Lemieux, e. a. (2011). Survival in women with breast cancer who used or did not use scalp","confidence":1,"confidence_rate":1},{"cnt":[[370,1547],[1878,1547],[1878,1596],[370,1596]],"region":{"top_left_x":369,"top_left_y":1546,"width":1509,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1208f2945b424029ab432fc27e6902d5","type":"text","conversion_output":true,"text":"cooling in the neoadjuvant/adjuvant setting. San Antonio Breast Cancer Symposium","text_display":" cooling in the neoadjuvant/adjuvant setting. 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(1998). \"Psychosocial adaptation of cancer survivors.","text_display":"\nKornblith, A. (1998). \"Psychosocial adaptation of cancer survivors.","confidence":1,"confidence_rate":1},{"cnt":[[245,1783],[1369,1783],[1369,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1783,"width":1125,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0678dcaff695471ca1d4276adb239611","type":"text","conversion_output":true,"text":".\" Holland JC ed. Psycho-Oncology. Holland JC ed. : 223-241.","text_display":"\n.\" Holland JC ed. Psycho-Oncology. Holland JC ed. : 223-241.","confidence":0.9791126251220703,"confidence_rate":0.9996753050004404},{"cnt":[[245,1835],[1880,1835],[1880,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1636,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a54e669b5ac54b27abe3534120992221","type":"text","conversion_output":true,"text":"Kroenke, K., R. L. 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The reduction in temperature is designed to effect","confidence":1,"confidence_rate":1},{"cnt":[[417,443],[1841,443],[1841,492],[417,492]],"region":{"top_left_x":416,"top_left_y":442,"width":1426,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65aa6ec5ff17428c989795e6cc798a60","type":"text","conversion_output":true,"text":"both vasoconstriction of the blood vessels in the scalp which supply the hair follicles","text_display":" both vasoconstriction of the blood vessels in the scalp which supply the hair follicles","confidence":1,"confidence_rate":1},{"cnt":[[417,490],[1764,490],[1764,539],[417,539]],"region":{"top_left_x":416,"top_left_y":489,"width":1348,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed9bb13ed40544a38368639f4c776808","type":"text","conversion_output":true,"text":"and also a reduction in the metabolic rate of the hair follicle cells, both of which","text_display":" and also a reduction in the metabolic rate of the hair follicle cells, both of which","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[417,537],[1828,537],[1828,591],[417,591]],"region":{"top_left_x":416,"top_left_y":537,"width":1413,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d970fc7531ff42e5b0581120645bfaa2","type":"text","conversion_output":true,"text":"mechanisms are intended to reduce the damage caused to the scalp hair follicle cells","text_display":" mechanisms are intended to reduce the damage caused to the scalp hair follicle cells","confidence":1,"confidence_rate":1},{"cnt":[[417,589],[1222,589],[1222,638],[417,638]],"region":{"top_left_x":416,"top_left_y":588,"width":807,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"655b103042114702b9063d9f7e64adee","type":"text","conversion_output":true,"text":"by cytostatic chemotherapy agents in the blood.","text_display":" by cytostatic chemotherapy agents in the blood.","confidence":1,"confidence_rate":1},{"cnt":[[417,655],[1863,655],[1863,707],[417,707]],"region":{"top_left_x":416,"top_left_y":655,"width":1447,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d440f75114c4386a57e59bcf8827690","type":"text","conversion_output":true,"text":"Scalp cooling is initiated at least 30 minutes prior to chemotherapy administration and","text_display":"\nScalp cooling is initiated at least 30 minutes prior to chemotherapy administration and","confidence":1,"confidence_rate":1},{"cnt":[[417,700],[1869,700],[1869,754],[417,754]],"region":{"top_left_x":416,"top_left_y":700,"width":1454,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"547380067bce481fa5b6203c681297f9","type":"text","conversion_output":true,"text":"is maintained continuously thereafter during administration of the chemotherapy agent","text_display":" is maintained continuously thereafter during administration of the chemotherapy agent","confidence":1,"confidence_rate":1},{"cnt":[[417,752],[1815,752],[1815,801],[417,801]],"region":{"top_left_x":416,"top_left_y":751,"width":1400,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dbc0e1bd0e9475a9293bc409cf58c17","type":"text","conversion_output":true,"text":"and also for a period of time after the agent has been administered. 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Recommended","text_display":" known pharmacokinetics of the chemotherapy treatment administered. Recommended","confidence":1,"confidence_rate":1},{"cnt":[[417,894],[1858,894],[1858,947],[417,947]],"region":{"top_left_x":416,"top_left_y":893,"width":1443,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"caa571eaeac44cc28e592c38ef7dc79c","type":"text","conversion_output":true,"text":"post-infusion cooling times for a variety of commonly used chemotherapy treatments,","text_display":" post-infusion cooling times for a variety of commonly used chemotherapy treatments,","confidence":1,"confidence_rate":1},{"cnt":[[417,941],[1732,941],[1732,993],[417,993]],"region":{"top_left_x":416,"top_left_y":941,"width":1316,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe6146d44598419999f726e2105fd892","type":"text","conversion_output":true,"text":"but for the purposes of this study have been standardized at 90 minutes. These","text_display":" but for the purposes of this study have been standardized at 90 minutes. These","confidence":1,"confidence_rate":1},{"cnt":[[417,990],[1830,990],[1830,1042],[417,1042]],"region":{"top_left_x":416,"top_left_y":990,"width":1415,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68ca1a8578f5460ba8c588fb390b4d3e","type":"text","conversion_output":true,"text":"regimens are designed to ensure that adequate cooling of the scalp occurs during the","text_display":" regimens are designed to ensure that adequate cooling of the scalp occurs during the","confidence":1,"confidence_rate":1},{"cnt":[[417,1040],[1717,1040],[1717,1089],[417,1089]],"region":{"top_left_x":416,"top_left_y":1039,"width":1301,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d374fa96dbb54be886fad5781feaae1a","type":"text","conversion_output":true,"text":"time when the concentration in the blood of the cytostatic agent is at its peak.","text_display":" time when the concentration in the blood of the cytostatic agent is at its peak.","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[417,1109],[1828,1109],[1828,1158],[417,1158]],"region":{"top_left_x":416,"top_left_y":1108,"width":1413,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb1d20dc39d3452999b3d77b9cf9f3ff","type":"text","conversion_output":true,"text":"As indicated above, effective scalp cooling relies on good contact between the inner","text_display":"\n\nAs indicated above, effective scalp cooling relies on good contact between the inner","confidence":1,"confidence_rate":1},{"cnt":[[417,1156],[1790,1156],[1790,1205],[417,1205]],"region":{"top_left_x":416,"top_left_y":1155,"width":1374,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4696546a3be94f31a68070cbbe1491e9","type":"text","conversion_output":true,"text":"surfaces of the cooling cap and the patient's scalp. 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\\multicolumn{2}{|l|}{CTCAE v4.0 Alopecia (Hair Loss)} \\\\\n\\hline Grade 0 & No hair loss \\\\\n\\hline Grade 1 & Hair loss of up to \\(50 \\%\\) of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage \\\\\n\\hline Grade 2 & Hair loss of > 50\\% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|l|}{CTCAE v4.0 Alopecia (Hair Loss)} \\\\\n\\hline Grade 0 & No hair loss \\\\\n\\hline Grade 1 & Hair loss of up to \\(50 \\%\\) of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but 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Do you have any trouble taking a long walk? & 1 & 2 & 3 & 4 \\\\\n\\hline 3. Do you have any trouble taking a short yalk outside of the house? & 1 & 2 & 3 & 4 \\\\\n\\hline 4. Do you need to stay in bed or a chair during the day? & 1 & 2 & 3 & 4 \\\\\n\\hline ![](https://cdn.mathpix.com/cropped/2ba50e9e-afe4-4227-92ef-99d5f23d6e0b-70.jpg?height=110\\&width=813\\&top_left_y=1138\\&top_left_x=279) & 1 & 2 & 3 & 4 \\\\\n\\hline During the past week: & Not at All & A Little & Quite a Bit & Very Much \\\\\n\\hline 6. Were you limited in doing either your work or ther dail & 1 & 2 & 3 & 4 \\\\\n\\hline 7. Were you limited in pursuing your hobbies or other leisure time activities? & 1 & 2 & 3 & 4 \\\\\n\\hline 8. Were you short of breath? & 1 & 2 & 3 & 4 \\\\\n\\hline 9. Have you had pain? & 1 & 2 & 3 & 4 \\\\\n\\hline 10. Did you need to rest? & 1 & 2 & 3 & 4 \\\\\n\\hline 11. Have you had trouble sleeping? & 1 & 2 & 3 & 4 \\\\\n\\hline 12. 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