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Such epidemiologic evidence suggests there may be","confidence":0.9130859375,"confidence_rate":0.998978889370525},{"cnt":[[305,965],[1807,965],[1807,1012],[305,1012]],"region":{"top_left_x":305,"top_left_y":964,"width":1502,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2003b282e2f4d92b8013762c8cdbda7","type":"text","conversion_output":true,"text":"substantial benefit to targeting treatment to a SBP \\(<120 mm Hg\\) instead of \\(<140 mm Hg\\).","text_display":" substantial benefit to targeting treatment to a SBP \\(<120 mm Hg\\) instead of \\(<140 mm Hg\\).","confidence":0.7243897259468213,"confidence_rate":0.9968127560613934},{"cnt":[[305,1010],[1687,1010],[1687,1057],[305,1057]],"region":{"top_left_x":305,"top_left_y":1009,"width":1382,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37c61a19c8c44c5d85b3e18c04333ae4","type":"text","conversion_output":true,"text":"In contrast, targeting to \\(<120 mm Hg\\) may be harmful or unnecessarily costly and","text_display":" In contrast, targeting to \\(<120 mm Hg\\) may be harmful or unnecessarily costly and","confidence":0.6833860874176025,"confidence_rate":0.9957316601155161},{"cnt":[[305,1053],[1674,1053],[1674,1102],[305,1102]],"region":{"top_left_x":305,"top_left_y":1052,"width":1369,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa5e6df9f25f40af8e0209ae48268169","type":"text","conversion_output":true,"text":"burdensome with limited expectation of benefit. Apart from the Action to Control","text_display":" burdensome with limited expectation of benefit. Apart from the Action to Control","confidence":1,"confidence_rate":1},{"cnt":[[305,1096],[1747,1096],[1747,1145],[305,1145]],"region":{"top_left_x":305,"top_left_y":1095,"width":1442,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34585d13c28a4483b4dda6a02f1fb2b7","type":"text","conversion_output":true,"text":"Cardiovascular Risk in Diabetes (ACCORD) trial, which was restricted to participants","text_display":" Cardiovascular Risk in Diabetes (ACCORD) trial, which was restricted to participants","confidence":1,"confidence_rate":1},{"cnt":[[305,1141],[1747,1141],[1747,1188],[305,1188]],"region":{"top_left_x":305,"top_left_y":1140,"width":1442,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e90b61d61f7545088a5b8d5c3c77e702","type":"text","conversion_output":true,"text":"with diabetes mellitus, no clinical trial has been conducted to test the hypothesis that","text_display":" with diabetes mellitus, no clinical trial has been conducted to test the hypothesis that","confidence":1,"confidence_rate":1},{"cnt":[[305,1186],[1764,1186],[1764,1231],[305,1231]],"region":{"top_left_x":305,"top_left_y":1185,"width":1459,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"519d5a94b5f0493a812cb569e3f0af0d","type":"text","conversion_output":true,"text":"more intensive reduction in SBP to \\(<120 mm Hg\\) is beneficial compared to the current","text_display":" more intensive reduction in SBP to \\(<120 mm Hg\\) is beneficial compared to the current","confidence":0.9653487205505371,"confidence_rate":0.9996208689370096},{"cnt":[[305,1229],[1783,1229],[1783,1278],[305,1278]],"region":{"top_left_x":305,"top_left_y":1228,"width":1479,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"caeebb4d1fc84401ab174aa98333af20","type":"text","conversion_output":true,"text":"recommendation of a goal SBP \\(<140 mm Hg\\). At present, the results from clinical trials","text_display":" recommendation of a goal SBP \\(<140 mm Hg\\). At present, the results from clinical trials","confidence":0.9469919204711914,"confidence_rate":0.9994328200996371},{"cnt":[[305,1274],[1798,1274],[1798,1321],[305,1321]],"region":{"top_left_x":305,"top_left_y":1274,"width":1494,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2f3a195bf674ac8a7c4140642cd3979","type":"text","conversion_output":true,"text":"that have addressed related hypotheses are ambiguous. A definitive clinical trial testing","text_display":" that have addressed related hypotheses are ambiguous. A definitive clinical trial testing","confidence":1,"confidence_rate":1},{"cnt":[[305,1317],[1800,1317],[1800,1364],[305,1364]],"region":{"top_left_x":305,"top_left_y":1316,"width":1496,"height":49},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d01f9d0dac04b189f3ded02153495a7","type":"text","conversion_output":true,"text":"whether lowering SBP below 120 mm Hg is better than lowering SBP below 140 mm Hg","text_display":" whether lowering SBP below 120 mm Hg is better than lowering SBP below 140 mm Hg","confidence":0.9970703125,"confidence_rate":0.999967758899593},{"cnt":[[305,1362],[1815,1362],[1815,1407],[305,1407]],"region":{"top_left_x":305,"top_left_y":1362,"width":1511,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8124671f31d84a7c8a912e93d851b74c","type":"text","conversion_output":true,"text":"in non-diabetic hypertensive patients is needed, and this has been designated by an NIH","text_display":" in non-diabetic hypertensive patients is needed, and this has been designated by an NIH","confidence":1,"confidence_rate":1},{"cnt":[[305,1405],[1695,1405],[1695,1452],[305,1452]],"region":{"top_left_x":305,"top_left_y":1405,"width":1391,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97efa9a81fea44b09a01ff3264d3513a","type":"text","conversion_output":true,"text":"Expert Panel as the most important hypothesis to test regarding the prevention of","text_display":" Expert Panel as the most important hypothesis to test regarding the prevention of","confidence":1,"confidence_rate":1},{"cnt":[[305,1448],[1038,1448],[1038,1497],[305,1497]],"region":{"top_left_x":305,"top_left_y":1448,"width":733,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7ec01983a4d4ac2bd9b065c325c3f50","type":"text","conversion_output":true,"text":"hypertension-related complications (2007).","text_display":" hypertension-related complications (2007).","confidence":0.9990234375,"confidence_rate":0.9999792121384572},{"cnt":[[303,1530],[917,1530],[917,1588],[303,1588]],"region":{"top_left_x":302,"top_left_y":1529,"width":616,"height":59},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3d162312ecf461e9410ce8f949ee688","type":"section_header","conversion_output":false,"children_ids":["f458f2fff6024067b6595037424e83b4"],"text":"","text_display":""},{"cnt":[[309,1536],[913,1536],[913,1583],[309,1583]],"region":{"top_left_x":309,"top_left_y":1536,"width":605,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f458f2fff6024067b6595037424e83b4","type":"text","conversion_output":true,"parent_id":"d3d162312ecf461e9410ce8f949ee688","text":"1.1.1 Prevalence of hypertension","text_display":"\n\n\\subsection*{1.1.1 Prevalence of hypertension}","confidence":0.9960954189300537,"confidence_rate":0.9998942698101639},{"cnt":[[305,1624],[1811,1624],[1811,1674],[305,1674]],"region":{"top_left_x":305,"top_left_y":1624,"width":1507,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"982ccfd198f34fe89c37952cab7328ea","type":"text","conversion_output":true,"text":"Approximately 1 billion people worldwide have hypertension (HTN) (Kearney and others,","text_display":"\n\nApproximately 1 billion people worldwide have hypertension (HTN) (Kearney and others,","confidence":0.9980475902557373,"confidence_rate":0.9999789860468112},{"cnt":[[305,1667],[1818,1667],[1818,1714],[305,1714]],"region":{"top_left_x":305,"top_left_y":1667,"width":1513,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb7a7e018925413fb9c20b246bfd5cf5","type":"text","conversion_output":true,"text":"2005). HTN is highly prevalent in the adult population of the US, especially among those","text_display":" 2005). HTN is highly prevalent in the adult population of the US, especially among those","confidence":0.9965834617614746,"confidence_rate":0.9999632008068607},{"cnt":[[305,1712],[1755,1712],[1755,1760],[305,1760]],"region":{"top_left_x":305,"top_left_y":1712,"width":1451,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dead16f12fd40a1aaef24b8f9110617","type":"text","conversion_output":true,"text":"aged \\(\\geq 60\\) years. Two-thirds of those over age 60 have HTN, and the prevalence has","text_display":" aged \\(\\geq 60\\) years. Two-thirds of those over age 60 have HTN, and the prevalence has","confidence":1,"confidence_rate":1},{"cnt":[[305,1757],[1618,1757],[1618,1803],[305,1803]],"region":{"top_left_x":305,"top_left_y":1757,"width":1313,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"798293acea0e4c84a0f10a853418c76b","type":"text","conversion_output":true,"text":"increased in recent decades (Chobanian and others, 2003;Cutler and others,","text_display":" increased in recent decades (Chobanian and others, 2003;Cutler and others,","confidence":1,"confidence_rate":1},{"cnt":[[305,1800],[1811,1800],[1811,1848],[305,1848]],"region":{"top_left_x":305,"top_left_y":1800,"width":1507,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d888a48b7b404761a7008d4611a0438c","type":"text","conversion_output":true,"text":"2008;Hajjar and Kotchen, 2003;Ong and others, 2007;World Health Organization, 2002).","text_display":" 2008;Hajjar and Kotchen, 2003;Ong and others, 2007;World Health Organization, 2002).","confidence":1,"confidence_rate":1},{"cnt":[[305,1843],[1794,1843],[1794,1893],[305,1893]],"region":{"top_left_x":305,"top_left_y":1843,"width":1489,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3df849c609fd407483940c15a0961caa","type":"text","conversion_output":true,"text":"By age 50 years, isolated systolic hypertension (ISH) is the most common form of HTN,","text_display":" By age 50 years, isolated systolic hypertension (ISH) is the most common form of HTN,","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[305,1886],[1654,1886],[1654,1936],[305,1936]],"region":{"top_left_x":305,"top_left_y":1886,"width":1350,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b5797b566ce4acbbcbd759ca109950a","type":"text","conversion_output":true,"text":"and is associated with greatest risk of target organ damage and adverse health","text_display":" and is associated with greatest risk of target organ damage and adverse health","confidence":1,"confidence_rate":1},{"cnt":[[305,1934],[1214,1934],[1214,1981],[305,1981]],"region":{"top_left_x":305,"top_left_y":1933,"width":909,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e489a71c6dc94c51aa5cc937c3342285","type":"text","conversion_output":true,"text":"outcomes (Franklin, 1999;Franklin and others, 2001).","text_display":" outcomes (Franklin, 1999;Franklin and others, 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factor}","confidence":1,"confidence_rate":1},{"cnt":[[305,2110],[1691,2110],[1691,2155],[305,2155]],"region":{"top_left_x":305,"top_left_y":2109,"width":1386,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1e9f922a6444130accf2db81e7952bd","type":"text","conversion_output":true,"text":"The importance of BP, especially SBP, as an independent risk factor for coronary","text_display":"\n\nThe importance of BP, especially SBP, as an independent risk factor for coronary","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[305,2153],[1772,2153],[1772,2198],[305,2198]],"region":{"top_left_x":305,"top_left_y":2152,"width":1468,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"252f391538304680b4e0272465b096e1","type":"text","conversion_output":true,"text":"events, stroke, chronic heart failure (CHF), and ESRD is well documented (Vasan and","text_display":" events, stroke, chronic heart failure (CHF), and ESRD is well documented (Vasan and","confidence":1,"confidence_rate":1},{"cnt":[[305,2196],[1768,2196],[1768,2241],[305,2241]],"region":{"top_left_x":305,"top_left_y":2195,"width":1464,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49f5a1ccb4864fd1b0cbb15acfe99ad1","type":"text","conversion_output":true,"text":"others, 2001;Collins and others, 1990;Macmahon and others, 1990;Sacco and others,","text_display":" others, 2001;Collins and others, 1990;Macmahon and others, 1990;Sacco and others,","confidence":0.9956073760986328,"confidence_rate":0.9999488117773798},{"cnt":[[305,2239],[1772,2239],[1772,2284],[305,2284]],"region":{"top_left_x":305,"top_left_y":2238,"width":1468,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54cb60a09fb64c4f9f4c5bf133f2a493","type":"text","conversion_output":true,"text":"2001;Jackson, 2000;Staessen and others, 1997;Hsu and others, 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There is also substantial epidemiologic and clinical trial evidence supporting a","text_display":" 1996). There is also substantial epidemiologic and clinical trial evidence supporting a","confidence":1,"confidence_rate":1},{"cnt":[[305,2372],[1669,2372],[1669,2417],[305,2417]],"region":{"top_left_x":305,"top_left_y":2371,"width":1365,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30fe39ec19ae43578a041354bf8d0251","type":"text","conversion_output":true,"text":"role for hypertension therapy in reducing risk for age-related dementia, including","text_display":" role for hypertension therapy in reducing risk for age-related dementia, including","confidence":1,"confidence_rate":1},{"cnt":[[305,2415],[1790,2415],[1790,2464],[305,2464]],"region":{"top_left_x":305,"top_left_y":2414,"width":1485,"height":51},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ecb7ac0f9504fb995336ff060438c9e","type":"text","conversion_output":true,"text":"vascular dementia and Alzheimer's dementia (Forette and others, 1998;Luchsinger and","text_display":" vascular dementia and Alzheimer's dementia (Forette and others, 1998;Luchsinger and","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9292d3484a2149aa9e063b31d4a9cb23","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1048,2638],[1079,2638],[1079,2679],[1048,2679]],"region":{"top_left_x":1048,"top_left_y":2638,"width":31,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1930e388c49941d4a09e6bce3ba8171d","type":"page_info","conversion_output":false,"text":"3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2675],[1521,2675]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49ebb3a78af34ed3aad7322ea12e2486","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-006","page":6,"lines":[{"cnt":[[305,249],[1755,249],[1755,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1451,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bdaba54866f4773ae789af5b14e39bf","type":"text","conversion_output":true,"text":"Mayeux, 2004;Reitz and others, 2007;Skoog and Gustafson, 2003;Skoog and others,","text_display":"\n\nMayeux, 2004;Reitz and others, 2007;Skoog and Gustafson, 2003;Skoog and others,","confidence":0.5946417208579979,"confidence_rate":0.993831056495663},{"cnt":[[305,296],[1740,296],[1740,342],[305,342]],"region":{"top_left_x":305,"top_left_y":296,"width":1436,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f7bb1bca64348b493ceccb515be3480","type":"text","conversion_output":true,"text":"2005;Skoog and Gustafson, 2006;Tzourio and others, 2003). Clinical trial data have","text_display":" 2005;Skoog and Gustafson, 2006;Tzourio and others, 2003). Clinical trial data have","confidence":0.9446517010219395,"confidence_rate":0.9993457429726958},{"cnt":[[305,339],[1798,339],[1798,385],[305,385]],"region":{"top_left_x":305,"top_left_y":339,"width":1494,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a32a4772fa014d07a0fd4d9ae5c35930","type":"text","conversion_output":true,"text":"shown reductions in CVD outcomes, including incident stroke ( \\(35 \\%\\) to \\(40 \\%\\) ), MI ( \\(15 \\%\\) to","text_display":" shown reductions in CVD outcomes, including incident stroke ( \\(35 \\%\\) to \\(40 \\%\\) ), MI ( \\(15 \\%\\) to","confidence":0.9830010430159887,"confidence_rate":0.999830260963918},{"cnt":[[305,382],[1796,382],[1796,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1492,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a74f6f3dd28498ab26d7131adc1a6cd","type":"text","conversion_output":true,"text":"\\(25 \\%\\) ), and CHF (up to \\(50 \\%\\) ) (Chobanian and others, 2003;Psaty and others, 1997; Neal,","text_display":" \\(25 \\%\\) ), and CHF (up to \\(50 \\%\\) ) (Chobanian and others, 2003;Psaty and others, 1997; Neal,","confidence":0.6903799211670503,"confidence_rate":0.9959807811316801},{"cnt":[[305,425],[1755,425],[1755,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1451,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d16443a90f484f05b26b0d2a2e870fe1","type":"text","conversion_output":true,"text":"Macmahon, and Chapman, 2000). However, optimal targets for BP lowering are not","text_display":" Macmahon, and Chapman, 2000). However, optimal targets for BP lowering are not","confidence":1,"confidence_rate":1},{"cnt":[[305,473],[518,473],[518,513],[305,513]],"region":{"top_left_x":305,"top_left_y":472,"width":213,"height":42},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4ffe68bc1e841f48ef8368eeafb2470","type":"text","conversion_output":true,"text":"established.","text_display":" established.","confidence":1,"confidence_rate":1},{"cnt":[[305,554],[907,554],[907,610],[305,610]],"region":{"top_left_x":305,"top_left_y":554,"width":602,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ba83304459041158115914c5eba998e","type":"section_header","conversion_output":false,"children_ids":["0dac41b479b7474e9edbf24c02ce327c"],"text":"","text_display":""},{"cnt":[[309,559],[902,559],[902,606],[309,606]],"region":{"top_left_x":309,"top_left_y":558,"width":594,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dac41b479b7474e9edbf24c02ce327c","type":"text","conversion_output":true,"parent_id":"3ba83304459041158115914c5eba998e","text":"1.1.3 Support for current target","text_display":"\n\n\\subsection*{1.1.3 Support for current target}","confidence":0.9990234375,"confidence_rate":0.9999735938716796},{"cnt":[[305,645],[1674,645],[1674,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1369,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"693b09551a704efabed3cc09a23973e2","type":"text","conversion_output":true,"text":"In addition to the Seventh Report of the Joint National Committee on Prevention,","text_display":"\n\nIn addition to the Seventh Report of the Joint National Committee on Prevention,","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[1777,692],[1777,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1472,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"541bb31ddf6540baa89d4c4a264c2177","type":"text","conversion_output":true,"text":"Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) (Chobanian and","text_display":" Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) (Chobanian and","confidence":1,"confidence_rate":1},{"cnt":[[305,735],[1798,735],[1798,780],[305,780]],"region":{"top_left_x":305,"top_left_y":734,"width":1494,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"121eb55736bc46fba1119cf2404e6365","type":"text","conversion_output":true,"text":"others, 2003), most recent practice guidelines recommend a target SBP \\(<140 mm Hg\\) in","text_display":" others, 2003), most recent practice guidelines recommend a target SBP \\(<140 mm Hg\\) in","confidence":0.9684465802274644,"confidence_rate":0.999655307217186},{"cnt":[[305,778],[1605,778],[1605,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1300,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0eec4895153f464392886f7d8853b529","type":"text","conversion_output":true,"text":"persons with established uncomplicated hypertension (Campbell and others,","text_display":" persons with established uncomplicated hypertension (Campbell and others,","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1775,821],[1775,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1470,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"441f441653554392b24a2bbdb3a0cc8f","type":"text","conversion_output":true,"text":"2009;Mancia and others, 2007;Mancia and others, 2009;National Collaborating Centre","text_display":" 2009;Mancia and others, 2007;Mancia and others, 2009;National Collaborating Centre","confidence":0.9664951922604814,"confidence_rate":0.9996083645858739},{"cnt":[[305,866],[1729,866],[1729,913],[305,913]],"region":{"top_left_x":305,"top_left_y":865,"width":1425,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"322244b87690455cbb19e7ea72c4ca78","type":"text","conversion_output":true,"text":"for Chronic Conditions, 2006;National Heart Foundation of Australia (National Blood","text_display":" for Chronic Conditions, 2006;National Heart Foundation of Australia (National Blood","confidence":0.9809911128832027,"confidence_rate":0.9997819342491087},{"cnt":[[305,907],[1721,907],[1721,956],[305,956]],"region":{"top_left_x":305,"top_left_y":906,"width":1416,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9337830763a4be889e7d1dc4522a7e5","type":"text","conversion_output":true,"text":"Pressure and Vascular Disease Advisory Committee), 2009;Whitworth, 2003). The","text_display":" Pressure and Vascular Disease Advisory Committee), 2009;Whitworth, 2003). The","confidence":0.99951171875,"confidence_rate":0.9999940439141021},{"cnt":[[305,954],[1794,954],[1794,1001],[305,1001]],"region":{"top_left_x":305,"top_left_y":953,"width":1489,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77afc74b3fef4c80aa1e3bc059150012","type":"text","conversion_output":true,"text":"benefits of lowering high BP in reducing CV morbidity and mortality are well-established","text_display":" benefits of lowering high BP in reducing CV morbidity and mortality are well-established","confidence":1,"confidence_rate":1},{"cnt":[[305,997],[1695,997],[1695,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":996,"width":1391,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e0062c5d892471e8b1ce62ae006fe07","type":"text","conversion_output":true,"text":"(Cutler, MacMahon, and Furberg, 1989;Psaty and others, 1997). A meta-analysis","text_display":" (Cutler, MacMahon, and Furberg, 1989;Psaty and others, 1997). A meta-analysis","confidence":0.9941470623016357,"confidence_rate":0.9999284155712211},{"cnt":[[305,1040],[1738,1040],[1738,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1434,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4961f6cf1c7f4a2dbeb273d028ff71c0","type":"text","conversion_output":true,"text":"evaluating the treatment efficacy of hypertension therapy in adults over age 60 , from","text_display":" evaluating the treatment efficacy of hypertension therapy in adults over age 60 , from","confidence":0.8610744476318359,"confidence_rate":0.9984100492298911},{"cnt":[[305,1085],[1764,1085],[1764,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1084,"width":1459,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90248f2dae504affaaa31ae854db1b07","type":"text","conversion_output":true,"text":"three major trials from different countries (Liu and others, 1998;SHEP, 1991;Staessen","text_display":" three major trials from different countries (Liu and others, 1998;SHEP, 1991;Staessen","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1721,1130],[1721,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1416,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4d91817b3db4cd39c8127b7b8ce815c","type":"text","conversion_output":true,"text":"and others, 1997) found that lowering SBP significantly reduced all-cause and CVD","text_display":" and others, 1997) found that lowering SBP significantly reduced all-cause and CVD","confidence":1,"confidence_rate":1},{"cnt":[[305,1173],[1781,1173],[1781,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1477,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"714004c82c7d4ed9b0b09cbb55ff8434","type":"text","conversion_output":true,"text":"mortality by \\(17 \\%\\) and \\(25 \\%\\) respectively, and all CVD end-points by \\(32 \\%\\) (Staessen and","text_display":" mortality by \\(17 \\%\\) and \\(25 \\%\\) respectively, and all CVD end-points by \\(32 \\%\\) (Staessen and","confidence":0.9985356330871582,"confidence_rate":0.9999847351149894},{"cnt":[[305,1216],[1749,1216],[1749,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1444,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eedcc7e26e304499a795758643ad323c","type":"text","conversion_output":true,"text":"others, 1999;Staessen, Wang, and Thijs, 2001), though both treatment goals and the","text_display":" others, 1999;Staessen, Wang, and Thijs, 2001), though both treatment goals and the","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[305,1263],[889,1263],[889,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1263,"width":585,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f172aecf4354cf2866185bbe71409d1","type":"text","conversion_output":true,"text":"achieved SBP were \\(>140 mm Hg\\).","text_display":" achieved SBP were \\(>140 mm Hg\\).","confidence":0.9990234375,"confidence_rate":0.9999755743071164},{"cnt":[[303,1343],[1364,1343],[1364,1399],[303,1399]],"region":{"top_left_x":302,"top_left_y":1342,"width":1063,"height":57},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78b4699ddb33424fa26f9469564c1a28","type":"section_header","conversion_output":false,"children_ids":["77b90b00d84c4c7da73add8e594aaca4"],"text":"","text_display":""},{"cnt":[[309,1349],[1360,1349],[1360,1394],[309,1394]],"region":{"top_left_x":309,"top_left_y":1349,"width":1051,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77b90b00d84c4c7da73add8e594aaca4","type":"text","conversion_output":true,"parent_id":"78b4699ddb33424fa26f9469564c1a28","text":"1.1.4 Risk of SBP above normal but below current target","text_display":"\n\n\\subsection*{1.1.4 Risk of SBP above normal but below current target}","confidence":1,"confidence_rate":1},{"cnt":[[305,1437],[1762,1437],[1762,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1437,"width":1457,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"485b934497b7434eace6837e07248f46","type":"text","conversion_output":true,"text":"The World Health Organization estimates that about two-thirds of the cerebrovascular","text_display":"\n\nThe World Health Organization estimates that about two-thirds of the cerebrovascular","confidence":0.99853515625,"confidence_rate":0.9999835291504493},{"cnt":[[305,1482],[1639,1482],[1639,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1482,"width":1335,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bd37f03ea0544128475193ea432c2bc","type":"text","conversion_output":true,"text":"disease burden and one-half of the coronary heart disease (CHD) burden on a","text_display":" disease burden and one-half of the coronary heart disease (CHD) burden on a","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1783,1525],[1783,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1525,"width":1479,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af44cd5e98274d4caa3cd05a25729bee","type":"text","conversion_output":true,"text":"worldwide basis is attributable to SBP \\(>115 mm Hg\\) (World Health Organization, 2002).","text_display":" worldwide basis is attributable to SBP \\(>115 mm Hg\\) (World Health Organization, 2002).","confidence":0.9824597691185772,"confidence_rate":0.9998117636384842},{"cnt":[[305,1568],[1732,1568],[1732,1613],[305,1613]],"region":{"top_left_x":305,"top_left_y":1568,"width":1427,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a704a9bb031041aba95634cbab62c021","type":"text","conversion_output":true,"text":"Further, SBP \\(>115 mm Hg\\) has been estimated to account for 7.6 million premature","text_display":" Further, SBP \\(>115 mm Hg\\) has been estimated to account for 7.6 million premature","confidence":0.9637041091918945,"confidence_rate":0.9995982223412274},{"cnt":[[305,1611],[1755,1611],[1755,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1451,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18c8425dcfe043788e101cf65100f090","type":"text","conversion_output":true,"text":"deaths ( \\(13.5 \\%\\) of the global total), 92 million disability-adjusted life years ( \\(6.0 \\%\\) of the","text_display":" deaths ( \\(13.5 \\%\\) of the global total), 92 million disability-adjusted life years ( \\(6.0 \\%\\) of 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About half of this","text_display":" global total), 54\\% of stroke, and 47\\% of ischemic heart disease. About half of this","confidence":0.935546875,"confidence_rate":0.9992431952981957},{"cnt":[[305,1697],[1734,1697],[1734,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1697,"width":1429,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a954822ed7a43a59238168e3357ce83","type":"text","conversion_output":true,"text":"burden is in persons with a SBP<145 mm Hg (Lawes, Vander, and Rodgers, 2008).","text_display":" burden is in persons with a SBP<145 mm Hg (Lawes, Vander, and Rodgers, 2008).","confidence":0.9570275992155075,"confidence_rate":0.9994644964985817},{"cnt":[[305,1745],[1766,1745],[1766,1790],[305,1790]],"region":{"top_left_x":305,"top_left_y":1744,"width":1462,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3186e3a1f2a40429417f8d062592f23","type":"text","conversion_output":true,"text":"The JNC-7 defined pre-hypertension based on the evidence that SBP values between","text_display":" The JNC-7 defined pre-hypertension based on the evidence that SBP values between","confidence":1,"confidence_rate":1},{"cnt":[[305,1788],[1794,1788],[1794,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1787,"width":1489,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee39b5306595477abdb89bc0e3a37baf","type":"text","conversion_output":true,"text":"120 and 139 mm Hg and diastolic blood pressure (DBP) values between 80 and 89 mm","text_display":" 120 and 139 mm Hg and diastolic blood pressure (DBP) values between 80 and 89 mm","confidence":0.9599609375,"confidence_rate":0.9995607128003474},{"cnt":[[305,1830],[1749,1830],[1749,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1830,"width":1444,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f9c687354c94cd49c12a95319f3fe7e","type":"text","conversion_output":true,"text":"Hg are associated with increased cardiovascular (CV) risk. Although the risk of a BP","text_display":" Hg are associated with increased cardiovascular (CV) risk. 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In the Framingham Heart Study (FHS), the","text_display":" and others, 2006) compared to higher SBPs. 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The ACCORD trial tested","text_display":" level, the ACCORD trial, found no clear evidence of benefit. 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The lack of overall benefit was","text_display":" meaningful effect (The ACCORD Study Group, 2010). The lack of overall benefit was","confidence":1,"confidence_rate":1},{"cnt":[[305,1306],[1635,1306],[1635,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":1330,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"963078ed49e04a0ea587ac410af36a27","type":"text","conversion_output":true,"text":"generally consistent across a variety of subgroups. This is in contrast to prior","text_display":" generally consistent across a variety of subgroups. 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In the European Trial on Reduction of Cardiac Events","text_display":" \\((23 \\%)\\) (Yusuf and others, 2000). 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More importantly, in","confidence":0.6971702575683594,"confidence_rate":0.9959551057892848},{"cnt":[[305,471],[1794,471],[1794,518],[305,518]],"region":{"top_left_x":305,"top_left_y":470,"width":1489,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f638ebfa80e24734a0aee07913576e9b","type":"text","conversion_output":true,"text":"a prespecified subgroup analysis, those receiving 2 drugs (perindopril plus indapamide)","text_display":" a prespecified subgroup analysis, those receiving 2 drugs (perindopril plus indapamide)","confidence":1,"confidence_rate":1},{"cnt":[[305,516],[1706,516],[1706,561],[305,561]],"region":{"top_left_x":305,"top_left_y":515,"width":1401,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f01784fde61f4404b4d282c0b502bb33","type":"text","conversion_output":true,"text":"had greater reductions in BP ( \\(12 / 5 mm Hg\\) ) and risk ( \\(43 \\%\\) ) compared with placebo","text_display":" had greater reductions in BP ( \\(12 / 5 mm Hg\\) ) and risk ( \\(43 \\%\\) ) compared with placebo","confidence":0.9839583818646715,"confidence_rate":0.9998297863019185},{"cnt":[[305,559],[1654,559],[1654,604],[305,604]],"region":{"top_left_x":305,"top_left_y":558,"width":1350,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2654537b27f4c3c91b0aacf4bc665de","type":"text","conversion_output":true,"text":"versus those on perindopril alone compared with placebo \\((5 / 3 mm Hg\\) and \\(5 \\%)\\),","text_display":" versus those on perindopril alone compared with placebo \\((5 / 3 mm Hg\\) and \\(5 \\%)\\),","confidence":0.8859074115753174,"confidence_rate":0.9986397704974701},{"cnt":[[305,602],[1772,602],[1772,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1468,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daf94064a9f34dbda18beff5fb0ceb4a","type":"text","conversion_output":true,"text":"supporting the hypothesis that lower BP is better. There were similar reductions in the","text_display":" supporting the hypothesis that lower BP is better. There were similar reductions in the","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1764,645],[1764,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1459,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6654c64af31440e97a17529ae87cefd","type":"text","conversion_output":true,"text":"risk of stroke in hypertensive and non-hypertensive subgroups (all \\(p<0.01\\) ). Finally, in","text_display":" risk of stroke in hypertensive and non-hypertensive subgroups (all \\(p<0.01\\) ). Finally, in","confidence":0.9347822666168213,"confidence_rate":0.9992977295538543},{"cnt":[[305,692],[1725,692],[1725,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1421,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7e7a572c5a844e5a23e28ced4e22232","type":"text","conversion_output":true,"text":"the Comparisson of Amlodipine vs. Enalapril to limit Occurences of Thrombosis trial","text_display":" the Comparisson of Amlodipine vs. Enalapril to limit Occurences of Thrombosis trial","confidence":1,"confidence_rate":1},{"cnt":[[305,735],[1803,735],[1803,780],[305,780]],"region":{"top_left_x":305,"top_left_y":734,"width":1498,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14cf5395658f4563bb3881fe0b3ebcfa","type":"text","conversion_output":true,"text":"(CAMELOT), a placebo-controlled trial of patients with heart disease and DBP \\(<100 mm\\)","text_display":" (CAMELOT), a placebo-controlled trial of patients with heart disease and DBP \\(<100 mm\\)","confidence":0.9580078125,"confidence_rate":0.9995234541836655},{"cnt":[[305,778],[1815,778],[1815,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1511,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d98a02e414ab448f96bdaff397cc2b5b","type":"text","conversion_output":true,"text":"Hg (mean \\(129 / 78 mm Hg\\) ), amlodipine decreased BP by \\(4.8 / 2.5 mm Hg\\) and CVD events","text_display":" Hg (mean \\(129 / 78 mm Hg\\) ), amlodipine decreased BP by \\(4.8 / 2.5 mm Hg\\) and CVD events","confidence":0.32566280104219913,"confidence_rate":0.9882600595098326},{"cnt":[[305,821],[1772,821],[1772,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1468,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30cf98e5d6e4491c90371e2facb2ff05","type":"text","conversion_output":true,"text":"by \\(31 \\%\\) (hazard ratio [HR], \\(0.69 ; 95 \\% CI , 0.54-0.88\\) ); whereas enalapril lowered BP by","text_display":" by \\(31 \\%\\) (hazard ratio [HR], \\(0.69 ; 95 \\% CI , 0.54-0.88\\) ); whereas enalapril lowered BP by","confidence":0.9917097059078515,"confidence_rate":0.9999132865754844},{"cnt":[[305,866],[1755,866],[1755,913],[305,913]],"region":{"top_left_x":305,"top_left_y":865,"width":1451,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e12c623da1cf45fdbcca3369d0aef5b4","type":"text","conversion_output":true,"text":"\\(4.9 / 2.4 mm Hg\\) but did not decrease events (HR, \\(0.85 ; 95 \\% Cl 0.67-1.07\\) ) (Nissen and","text_display":" \\(4.9 / 2.4 mm Hg\\) but did not decrease events (HR, \\(0.85 ; 95 \\% Cl 0.67-1.07\\) ) (Nissen and","confidence":0.9205690542385974,"confidence_rate":0.9991008038352704},{"cnt":[[305,911],[552,911],[552,956],[305,956]],"region":{"top_left_x":305,"top_left_y":910,"width":248,"height":47},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af59b5007421478d97f9a26d23475b3d","type":"text","conversion_output":true,"text":"others, 2004).","text_display":" others, 2004).","confidence":1,"confidence_rate":1},{"cnt":[[305,997],[1811,997],[1811,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":996,"width":1507,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a349d57a377d457f84863ac78c79cb8b","type":"text","conversion_output":true,"text":"Other trials have not supported the hypothesis of benefit from a lower SBP target. In the","text_display":"\n\nOther trials have not supported the hypothesis of benefit from a lower SBP target. In the","confidence":1,"confidence_rate":1},{"cnt":[[305,1040],[1742,1040],[1742,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1438,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de72fe2f7918489ca68fbd4655e5da69","type":"text","conversion_output":true,"text":"HOT study, there were no differences in CVD events between groups randomized to","text_display":" HOT study, there were no differences in CVD events between groups randomized to","confidence":1,"confidence_rate":1},{"cnt":[[305,1085],[1783,1085],[1783,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1084,"width":1479,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67a2ace0bbd140278c5f5ee3b35fc27f","type":"text","conversion_output":true,"text":"target DBPs of \\(\\leq 90 mm Hg\\) vs \\(\\leq 85 mm Hg\\) vs \\(\\leq 80 mm Hg\\) in the entire cohort of 18,790","text_display":" target DBPs of \\(\\leq 90 mm Hg\\) vs \\(\\leq 85 mm Hg\\) vs \\(\\leq 80 mm Hg\\) in the entire cohort of 18,790","confidence":0.9602709780447185,"confidence_rate":0.9995986967263413},{"cnt":[[305,1130],[1760,1130],[1760,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1455,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"443e316385d349f5aaa4f5e79bbd2464","type":"text","conversion_output":true,"text":"hypertensive participants; the average on-treatment SBP levels were 140 mm Hg and","text_display":" hypertensive participants; the average on-treatment SBP levels were 140 mm Hg and","confidence":0.99853515625,"confidence_rate":0.999983891144227},{"cnt":[[305,1173],[1693,1173],[1693,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1388,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"697284bfc58f4a06897c686e2af645bb","type":"text","conversion_output":true,"text":"144 mm Hg , respectively, in the \\(\\leq 80\\) and \\(\\leq 90 mm Hg\\) target groups (Hansson and","text_display":" 144 mm Hg , respectively, in the \\(\\leq 80\\) and \\(\\leq 90 mm Hg\\) target groups (Hansson and","confidence":0.9728422164916992,"confidence_rate":0.9996974812424825},{"cnt":[[305,1216],[1800,1216],[1800,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1496,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef221dca37a34751b9d930cfa30b177d","type":"text","conversion_output":true,"text":"others, 1998). Only a post hoc analysis of the diabetic subgroup ( \\(n =1,501\\) ) showed that","text_display":" others, 1998). Only a post hoc analysis of the diabetic subgroup ( \\(n =1,501\\) ) showed that","confidence":0.9970715045928955,"confidence_rate":0.9999703762787923},{"cnt":[[305,1261],[1803,1261],[1803,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1261,"width":1498,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8682b94fa9a847dc9023d93477152f2e","type":"text","conversion_output":true,"text":"major CVD events were reduced by \\(51 \\%( p =0.005)\\) in those randomized to the lower BP","text_display":" major CVD events were reduced by \\(51 \\%( p =0.005)\\) in those randomized to the lower BP","confidence":0.9717442619148642,"confidence_rate":0.999688498372734},{"cnt":[[305,1306],[1747,1306],[1747,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":1442,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdaf9fa9ef41479f88023909487ac143","type":"text","conversion_output":true,"text":"goal. The average on-treatment SBP levels were 140 mm Hg and 144 mm Hg in the","text_display":" goal. The average on-treatment SBP levels were 140 mm Hg and 144 mm Hg in the","confidence":1,"confidence_rate":1},{"cnt":[[305,1349],[1794,1349],[1794,1396],[305,1396]],"region":{"top_left_x":305,"top_left_y":1349,"width":1489,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"262fdc0a60864eb28509ab2d0d0a649b","type":"text","conversion_output":true,"text":"\\(\\leq 80\\) and \\(\\leq 90 mm\\) Hg target groups, respectively (Hansson and others, 1998). Likewise,","text_display":" \\(\\leq 80\\) and \\(\\leq 90 mm\\) Hg target groups, respectively (Hansson and others, 1998). Likewise,","confidence":0.9575600624084473,"confidence_rate":0.9995287324778442},{"cnt":[[305,1392],[1777,1392],[1777,1439],[305,1439]],"region":{"top_left_x":305,"top_left_y":1392,"width":1472,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fc2c7ae86b141c6a9532b5521021d48","type":"text","conversion_output":true,"text":"there was no special benefit in those with an achieved SBP of 130 mm Hg vs. 134 mm","text_display":" there was no special benefit in those with an achieved SBP of 130 mm Hg vs. 134 mm","confidence":0.99169921875,"confidence_rate":0.9999103757952092},{"cnt":[[305,1435],[1712,1435],[1712,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1435,"width":1408,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d47f499025c40dea48b0c9cfa41e77c","type":"text","conversion_output":true,"text":"Hg in the Prevention of Events with Angiotensin Converting Enzyme (PEACE) trial,","text_display":" Hg in the Prevention of Events with Angiotensin Converting Enzyme (PEACE) trial,","confidence":0.90283203125,"confidence_rate":0.9987981492162884},{"cnt":[[305,1482],[1811,1482],[1811,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1482,"width":1507,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25084af312304ca794b3d03de4126a75","type":"text","conversion_output":true,"text":"which compared trandolapril treatment to placebo in persons with stable coronary artery","text_display":" which compared trandolapril treatment to placebo in persons with stable coronary artery","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1772,1525],[1772,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1525,"width":1468,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8949ef679b7c4923bd9558f302e2dcaa","type":"text","conversion_output":true,"text":"disease (Braunwald and others, 2004). In the aggregate, these trials had only modest","text_display":" disease (Braunwald and others, 2004). In the aggregate, these trials had only modest","confidence":1,"confidence_rate":1},{"cnt":[[305,1568],[1807,1568],[1807,1613],[305,1613]],"region":{"top_left_x":305,"top_left_y":1568,"width":1502,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42f091019d724f71b4ee00287397ccd0","type":"text","conversion_output":true,"text":"net reductions in SBP ( \\(4-6 mm Hg\\) ), though ACCORD and other trials have shown that a","text_display":" net reductions in SBP ( \\(4-6 mm Hg\\) ), though ACCORD and other trials have shown that a","confidence":0.96484375,"confidence_rate":0.9996233435018066},{"cnt":[[305,1611],[1712,1611],[1712,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1408,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d25cf4d6ef3f4ac9a10a5976b2eba584","type":"text","conversion_output":true,"text":"much larger reduction ( 14 mm Hg difference in SBP between the two arms) can be","text_display":" much larger reduction ( 14 mm Hg difference in SBP between the two arms) can be","confidence":0.5580001941661976,"confidence_rate":0.993609561550885},{"cnt":[[305,1659],[479,1659],[479,1699],[305,1699]],"region":{"top_left_x":305,"top_left_y":1658,"width":175,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"368e6b6f8e8c41bebbbfa015710a22d2","type":"text","conversion_output":true,"text":"achieved.","text_display":" achieved.","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1772,1745],[1772,1790],[305,1790]],"region":{"top_left_x":305,"top_left_y":1744,"width":1468,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a8282ef24dc4adf8a043edd1cc5b306","type":"text","conversion_output":true,"text":"The ACCORD BP results provide a strong rationale for testing the potential benefits of","text_display":"\n\nThe ACCORD BP results provide a strong rationale for testing the potential benefits of","confidence":0.99658203125,"confidence_rate":0.9999623762753774},{"cnt":[[305,1788],[1747,1788],[1747,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1787,"width":1442,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bc30576616243e4b395e67fee13774b","type":"text","conversion_output":true,"text":"intensive BP lowering. (i) The confidence interval around ACCORD's non-significant","text_display":" intensive BP lowering. (i) The confidence interval around ACCORD's non-significant","confidence":1,"confidence_rate":1},{"cnt":[[305,1830],[1762,1830],[1762,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1830,"width":1457,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1061db37fc342a788083d2b39ef0e57","type":"text","conversion_output":true,"text":"effect does not exclude benefit in the range of \\(20 \\%\\) to \\(25 \\%\\) reduction in the rate of CV","text_display":" effect does not exclude benefit in the range of \\(20 \\%\\) to \\(25 \\%\\) reduction in the rate of CV","confidence":0.9733108095824718,"confidence_rate":0.9997211542095038},{"cnt":[[305,1876],[1781,1876],[1781,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1875,"width":1477,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18d83eefc0584d6ca797dec73faabb8d","type":"text","conversion_output":true,"text":"events. Effects of that magnitude would be of considerable importance to public health.","text_display":" events. Effects of that magnitude would be of considerable importance to public health.","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1760,1921],[1760,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1455,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86509069dc6a4ec7b257919104a1ff46","type":"text","conversion_output":true,"text":"(ii) Serious adverse effects were significantly more frequent in the intensive treatment","text_display":" (ii) Serious adverse effects were significantly more frequent in the intensive treatment","confidence":1,"confidence_rate":1},{"cnt":[[305,1964],[1755,1964],[1755,2009],[305,2009]],"region":{"top_left_x":305,"top_left_y":1963,"width":1451,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c51dc74a5774e0fbaa3e82a6e3a59e0","type":"text","conversion_output":true,"text":"group, but occurred with low frequency overall. (iii) People without diabetes, who are","text_display":" group, but occurred with low frequency overall. (iii) People without diabetes, who are","confidence":1,"confidence_rate":1},{"cnt":[[305,2007],[1760,2007],[1760,2054],[305,2054]],"region":{"top_left_x":305,"top_left_y":2006,"width":1455,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dd5bba695a84c4eb47ce156d54ebf2c","type":"text","conversion_output":true,"text":"probably less prone to microvascular disease but were excluded from ACCORD, may","text_display":" probably less prone to microvascular disease but were excluded from ACCORD, may","confidence":1,"confidence_rate":1},{"cnt":[[305,2052],[1738,2052],[1738,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2051,"width":1434,"height":49},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"859ac51137da4fb18285666065dcb16f","type":"text","conversion_output":true,"text":"benefit from more intensive BP lowering. (iv) ACCORD excluded people with serum","text_display":" benefit from more intensive BP lowering. (iv) ACCORD excluded people with serum","confidence":1,"confidence_rate":1},{"cnt":[[305,2097],[1768,2097],[1768,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2096,"width":1464,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33d9765e536541d2a6d644a736125ce5","type":"text","conversion_output":true,"text":"creatinine levels \\(>1.5 mg / dL\\), which are prevalent in the US population and associated","text_display":" creatinine levels \\(>1.5 mg / dL\\), which are prevalent in the US population and associated","confidence":0.998046875,"confidence_rate":0.9999802523683627},{"cnt":[[305,2140],[1796,2140],[1796,2185],[305,2185]],"region":{"top_left_x":305,"top_left_y":2139,"width":1492,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa8cdb40653b406f9fd71c088e0f19a9","type":"text","conversion_output":true,"text":"with high CV risk. (v) the glycemia arm of the ACCORD trial was stopped early because","text_display":" with high CV risk. (v) the glycemia arm of the ACCORD trial was stopped early because","confidence":1,"confidence_rate":1},{"cnt":[[305,2183],[1682,2183],[1682,2228],[305,2228]],"region":{"top_left_x":305,"top_left_y":2182,"width":1378,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd87b6e7ab764459be84a32219debb9b","type":"text","conversion_output":true,"text":"of an excess in total mortality and the possibility of interaction between these two","text_display":" of an excess in total mortality and the possibility of interaction between these two","confidence":1,"confidence_rate":1},{"cnt":[[305,2226],[1811,2226],[1811,2273],[305,2273]],"region":{"top_left_x":305,"top_left_y":2225,"width":1507,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2effd59ff0f146db8283421fe36731f8","type":"text","conversion_output":true,"text":"interventions is still under investigation. The safety and benefit of intensive BP reduction","text_display":" interventions is still under investigation. The safety and benefit of intensive BP reduction","confidence":1,"confidence_rate":1},{"cnt":[[305,2273],[1807,2273],[1807,2318],[305,2318]],"region":{"top_left_x":305,"top_left_y":2273,"width":1502,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d2636af97564979b09d1ae58564570f","type":"text","conversion_output":true,"text":"in patients > age 75 remain to be tested. Thus, it is imperative that the potential benefits","text_display":" in patients > age 75 remain to be tested. Thus, it is imperative that the potential benefits","confidence":0.99755859375,"confidence_rate":0.9999755563853322},{"cnt":[[305,2316],[1772,2316],[1772,2361],[305,2361]],"region":{"top_left_x":305,"top_left_y":2316,"width":1468,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e671b923e2d47d5b499c73aa8ab859a","type":"text","conversion_output":true,"text":"and harms of intense SBP-lowering be examined definitively in this and other high-risk","text_display":" and harms of intense SBP-lowering be examined definitively in this and other high-risk","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[305,2359],[1624,2359],[1624,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1320,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e83ee5c67594b3a8123fd4c923a4ea5","type":"text","conversion_output":true,"text":"populations, e.g. those with chronic kidney disease (CKD) or underlying CVD.","text_display":" populations, e.g. those with chronic kidney disease (CKD) or underlying CVD.","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30225d8cef1249bfb4b312f6d757e2f1","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1048,2638],[1079,2638],[1079,2679],[1048,2679]],"region":{"top_left_x":1048,"top_left_y":2638,"width":31,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13885d6a7c8a4ae8a6f85bb9685ef937","type":"page_info","conversion_output":false,"text":"6","text_display":"","confidence":0.99951171875,"confidence_rate":0.99951171875},{"cnt":[[1521,2636],[1815,2636],[1815,2675],[1521,2675]],"region":{"top_left_x":1521,"top_left_y":2636,"width":295,"height":39},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e7940ea5be843e5a23f9f77ddc83e9d","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-009","page":9,"lines":[{"cnt":[[301,245],[1377,245],[1377,305],[301,305]],"region":{"top_left_x":300,"top_left_y":244,"width":1078,"height":62},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64f0b5af9e304bd1b9a49ce22f3e24c4","type":"section_header","conversion_output":false,"children_ids":["a2427f1749fe4743b7863fd702510d91"],"text":"","text_display":""},{"cnt":[[309,249],[1373,249],[1373,299],[309,299]],"region":{"top_left_x":309,"top_left_y":249,"width":1064,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2427f1749fe4743b7863fd702510d91","type":"text","conversion_output":true,"parent_id":"64f0b5af9e304bd1b9a49ce22f3e24c4","text":"1.1.6 Possible harm from treatment of SBP to \\(<120 mm Hg\\)","text_display":"\n\n\\subsection*{1.1.6 Possible harm from treatment of SBP to \\(<120 mm Hg\\)}","confidence":0.46157013504974365,"confidence_rate":0.9874058593129686},{"cnt":[[305,339],[1779,339],[1779,385],[305,385]],"region":{"top_left_x":305,"top_left_y":339,"width":1474,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"191386d9a1c24da7b30cda882aa0d9ad","type":"text","conversion_output":true,"text":"There are a number of reasons for requiring recommendations to lower SBP treatment","text_display":"\n\nThere are a number of reasons for requiring recommendations to lower SBP treatment","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1807,382],[1807,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1502,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dabf6c4e600a4513b1593e6b5d3a6cf4","type":"text","conversion_output":true,"text":"goals be based on definitive trial evidence. Treating to lower BP levels with medications","text_display":" goals be based on definitive trial evidence. Treating to lower BP levels with medications","confidence":1,"confidence_rate":1},{"cnt":[[305,425],[1818,425],[1818,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1513,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"250367bd8b8c49df87d2e0e7df66dd01","type":"text","conversion_output":true,"text":"could be harmful. For example, one proposed mechanism that has some support in post","text_display":" could be harmful. For example, one proposed mechanism that has some support in post","confidence":1,"confidence_rate":1},{"cnt":[[305,468],[1796,468],[1796,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1492,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f56f8f19969d46b7bb46c158d2c3e728","type":"text","conversion_output":true,"text":"hoc analyses of clinical trials (Cruickshank and others, 1987;Cruickshank, 2000;Somes,","text_display":" hoc analyses of clinical trials (Cruickshank and others, 1987;Cruickshank, 2000;Somes,","confidence":1,"confidence_rate":1},{"cnt":[[305,511],[1768,511],[1768,561],[305,561]],"region":{"top_left_x":305,"top_left_y":511,"width":1464,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0117b7fe17e7483b8e4c505a622d4ac2","type":"text","conversion_output":true,"text":"Shorr, and Pahor, 1999), known as the \"J-curve\" hypothesis, states that lowering DBP","text_display":" Shorr, and Pahor, 1999), known as the \"J-curve\" hypothesis, states that lowering DBP","confidence":1,"confidence_rate":1},{"cnt":[[305,559],[1779,559],[1779,604],[305,604]],"region":{"top_left_x":305,"top_left_y":558,"width":1474,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d96e83303cd40f1a071721a98af2c7d","type":"text","conversion_output":true,"text":"too much may decrease coronary artery perfusion and increase the risk of CVD events","text_display":" too much may decrease coronary artery perfusion and increase the risk of CVD events","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1762,602],[1762,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1457,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c642e36beaf4a84b3fd10f765f69f31","type":"text","conversion_output":true,"text":"in patients with coronary artery disease (CAD). In post-hoc observational analyses of","text_display":" in patients with coronary artery disease (CAD). In post-hoc observational analyses of","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1781,645],[1781,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1477,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03e1be35d33f43b991b99eb724fabdb7","type":"text","conversion_output":true,"text":"clinical trial experience, the level of DBP below which risk increased has varied by trial,","text_display":" clinical trial experience, the level of DBP below which risk increased has varied by trial,","confidence":1,"confidence_rate":1},{"cnt":[[305,690],[1609,690],[1609,737],[305,737]],"region":{"top_left_x":305,"top_left_y":689,"width":1305,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc28ce43b9e1464fa575e5e5cc920904","type":"text","conversion_output":true,"text":"sometimes being as high as < 85 mm Hg (Cruickshank and others, 1987). In","text_display":" sometimes being as high as < 85 mm Hg (Cruickshank and others, 1987). In","confidence":0.5361275549512357,"confidence_rate":0.9924265901036313},{"cnt":[[305,733],[1742,733],[1742,780],[305,780]],"region":{"top_left_x":305,"top_left_y":732,"width":1438,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e404bc547eaf4f79bc952375b9388f9e","type":"text","conversion_output":true,"text":"corresponding analyses of SHEP participants, the higher risk was reported with DBP","text_display":" corresponding analyses of SHEP participants, the higher risk was reported with DBP","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1321,778],[1321,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1017,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e75424dd4eb74e6fa06d9149e3d0793f","type":"text","conversion_output":true,"text":"\\(<55-60 mm Hg\\) during treatment (Somes and others, 1999).","text_display":" \\(<55-60 mm Hg\\) during treatment (Somes and others, 1999).","confidence":0.9975602623308077,"confidence_rate":0.9999599562332695},{"cnt":[[305,864],[1721,864],[1721,913],[305,913]],"region":{"top_left_x":305,"top_left_y":863,"width":1416,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3335edcd5fe54ff08d13cdd4981291f6","type":"text","conversion_output":true,"text":"Further, if treatment has little or no benefit, adding drugs is a waste of patients' and","text_display":"\n\nFurther, if treatment has little or no benefit, adding drugs is a waste of patients' and","confidence":1,"confidence_rate":1},{"cnt":[[305,907],[1766,907],[1766,956],[305,956]],"region":{"top_left_x":305,"top_left_y":906,"width":1462,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38c398e1850b4d96be1e9b6f356abaf2","type":"text","conversion_output":true,"text":"payers' resources and time. For example, in a cost-effectiveness analysis of the HOT","text_display":" payers' resources and time. For example, in a cost-effectiveness analysis of the HOT","confidence":1,"confidence_rate":1},{"cnt":[[305,954],[1704,954],[1704,1001],[305,1001]],"region":{"top_left_x":305,"top_left_y":953,"width":1399,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7cdd5d0657843e39dcdf57dd2e54f0f","type":"text","conversion_output":true,"text":"trial, which overall did not show a significant benefit for lower DBP goals, the cost-","text_display":" trial, which overall did not show a significant benefit for lower DBP goals, the cost","confidence":1,"confidence_rate":1},{"cnt":[[305,997],[1775,997],[1775,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":996,"width":1470,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0052e64bf1354bc3bb8cf31f79e55237","type":"text","conversion_output":true,"text":"effectiveness ratios, expressed as cost per year of life gained, were most favorable for","text_display":"effectiveness ratios, expressed as cost per year of life gained, were most favorable for","confidence":1,"confidence_rate":1},{"cnt":[[305,1040],[1742,1040],[1742,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1438,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"283b1995f32f42b08e47dd0723e14ceb","type":"text","conversion_output":true,"text":"the DBP \\(\\leq 90 mm\\) Hg target group ( \\(\\$ 4262\\) ) and for added aspirin treatment ( \\(\\$ 12,710\\) )","text_display":" the DBP \\(\\leq 90 mm\\) Hg target group ( \\(\\$ 4262\\) ) and for added aspirin treatment ( \\(\\$ 12,710\\) )","confidence":0.30815383558011833,"confidence_rate":0.9882974522199325},{"cnt":[[305,1085],[1790,1085],[1790,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1084,"width":1485,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4d80f6ab84b4c1796232ca21078cd1d","type":"text","conversion_output":true,"text":"(HOT, 1998). In the moderately intensive treatment (DBP \\(\\leq 85 mm Hg\\) ) group, the cost-","text_display":" (HOT, 1998). In the moderately intensive treatment (DBP \\(\\leq 85 mm Hg\\) ) group, the cost","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1745,1130],[1745,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1440,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62c0907566e94bef8cce0f10dd561891","type":"text","conversion_output":true,"text":"effectiveness ratio escalated to \\(\\$ 86,360\\); with intensive treatment (DBP \\(\\leq 80 mm Hg\\) ),","text_display":"effectiveness ratio escalated to \\(\\$ 86,360\\); with intensive treatment (DBP \\(\\leq 80 mm Hg\\) ),","confidence":0.995611188467592,"confidence_rate":0.9999551186537546},{"cnt":[[305,1173],[1732,1173],[1732,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1427,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd570d55eadb41968774a3032b100714","type":"text","conversion_output":true,"text":"costs further increased to \\(\\$ 658,370\\) per year of life gained. Only treatment to a DBP","text_display":" costs further increased to \\(\\$ 658,370\\) per year of life gained. Only treatment to a DBP","confidence":0.990234375,"confidence_rate":0.9998933358906693},{"cnt":[[305,1216],[1777,1216],[1777,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1472,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32b95a778b72450480354b9486fcc9d7","type":"text","conversion_output":true,"text":"target of 90 mm Hg and co-administering aspirin were considered highly cost effective;","text_display":" target of 90 mm Hg and co-administering aspirin were considered highly cost effective;","confidence":0.9267578125,"confidence_rate":0.9992079908155018},{"cnt":[[305,1261],[1414,1261],[1414,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1261,"width":1109,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b08607c8d05c47c5be6943b0cc1698e6","type":"text","conversion_output":true,"text":"intensive BP lowering down to 80 mm Hg was clearly very costly.","text_display":" intensive BP lowering down to 80 mm Hg was clearly very costly.","confidence":0.89013671875,"confidence_rate":0.9984070206682878},{"cnt":[[305,1349],[1721,1349],[1721,1396],[305,1396]],"region":{"top_left_x":305,"top_left_y":1349,"width":1416,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4bad7bb9aa54b359fdc35cd9f6aef9f","type":"text","conversion_output":true,"text":"A third reason for not recommending lower SBP goals without definitive clinical trial","text_display":"\n\nA third reason for not recommending lower SBP goals without definitive clinical trial","confidence":1,"confidence_rate":1},{"cnt":[[305,1392],[1798,1392],[1798,1439],[305,1439]],"region":{"top_left_x":305,"top_left_y":1392,"width":1494,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f04c20bcddad44bd8d7ec71851c01a6d","type":"text","conversion_output":true,"text":"evidence relates to the increased number of drugs required to achieve these goals. For","text_display":" evidence relates to the increased number of drugs required to achieve these goals. For","confidence":1,"confidence_rate":1},{"cnt":[[305,1435],[1742,1435],[1742,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1435,"width":1438,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d80d678354a24309a816ce4204e3f359","type":"text","conversion_output":true,"text":"example, in the African American Study of Kidney disease and hypertension (AASK)","text_display":" example, in the African American Study of Kidney disease and hypertension (AASK)","confidence":1,"confidence_rate":1},{"cnt":[[305,1480],[1783,1480],[1783,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1480,"width":1479,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a463b61c57c4dcaa7aadc9bd3859815","type":"text","conversion_output":true,"text":"trial, the intensive BP goal (achieved SBP \\(=128 mm Hg\\) ) group required an average of","text_display":" trial, the intensive BP goal (achieved SBP \\(=128 mm Hg\\) ) group required an average of","confidence":0.9951193332672119,"confidence_rate":0.9999479522472647},{"cnt":[[305,1523],[1815,1523],[1815,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1523,"width":1511,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb641cc0ed2946b990c6a3c28fd5191e","type":"text","conversion_output":true,"text":"3.04 drug classes compared with 2.39 in the conventional BP goal group (Wright, Jr. and","text_display":" 3.04 drug classes compared with 2.39 in the conventional BP goal group (Wright, Jr. and","confidence":1,"confidence_rate":1},{"cnt":[[305,1568],[1783,1568],[1783,1613],[305,1613]],"region":{"top_left_x":305,"top_left_y":1568,"width":1479,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3063f5ac0ecd4e2ab3b327b5e0908cf6","type":"text","conversion_output":true,"text":"others, 2002a) and in the ACCORD BP trial experience \\(>3\\) drug classes were required","text_display":" others, 2002a) and in the ACCORD BP trial experience \\(>3\\) drug classes were required","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[305,1611],[1760,1611],[1760,1659],[305,1659]],"region":{"top_left_x":305,"top_left_y":1611,"width":1455,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a8ee036a7d349f0b37571255e956775","type":"text","conversion_output":true,"text":"for the intensive SBP goal group to achieve a SBP average of 119 mm Hg , compared","text_display":" for the intensive SBP goal group to achieve a SBP average of 119 mm Hg , compared","confidence":0.9990236759185791,"confidence_rate":0.9999892659807285},{"cnt":[[305,1656],[1777,1656],[1777,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1656,"width":1472,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"426f1399488b4684af310d585171cff1","type":"text","conversion_output":true,"text":"with 2 classes in the standard SBP goal group with a mean SBP achieved of 134 mm","text_display":" with 2 classes in the standard SBP goal group with a mean SBP achieved of 134 mm","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[305,1697],[1734,1697],[1734,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1697,"width":1429,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14255c781f1143708eddbeaa7131251a","type":"text","conversion_output":true,"text":"Hg (The ACCORD Study Group, 2010). In addition to being more costly and having","text_display":" Hg (The ACCORD Study Group, 2010). In addition to being more costly and having","confidence":0.95703125,"confidence_rate":0.9994709925769885},{"cnt":[[305,1745],[1755,1745],[1755,1792],[305,1792]],"region":{"top_left_x":305,"top_left_y":1744,"width":1451,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f40669b51d504a64b2abf72278062fc9","type":"text","conversion_output":true,"text":"greater potential for drug-related adverse events, even 1-2 more medications per day","text_display":" greater potential for drug-related adverse events, even 1-2 more medications per day","confidence":0.99853515625,"confidence_rate":0.9999835291504493},{"cnt":[[305,1788],[1725,1788],[1725,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1787,"width":1421,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7217bf2392234988b7c6cb3ea09680fa","type":"text","conversion_output":true,"text":"may contribute to reduced adherence to other evidence-based drug treatment (e.g.,","text_display":" may contribute to reduced adherence to other evidence-based drug treatment (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[305,1830],[1781,1830],[1781,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1830,"width":1477,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4fce8bd1b444b46b12fa26d9163b7a9","type":"text","conversion_output":true,"text":"statins or aspirin). Patients may choose to not take medications without more evidence","text_display":" statins or aspirin). Patients may choose to not take medications without more evidence","confidence":1,"confidence_rate":1},{"cnt":[[305,1876],[1725,1876],[1725,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1875,"width":1421,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"693ce411a8ad46b58891cc853ad28e5d","type":"text","conversion_output":true,"text":"for safety and benefit. In addition to being more costly, burdensome, and potentially","text_display":" for safety and benefit. In addition to being more costly, burdensome, and potentially","confidence":1,"confidence_rate":1},{"cnt":[[305,1919],[1755,1919],[1755,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1918,"width":1451,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37fd41e5feb34cb794147bd04da654b4","type":"text","conversion_output":true,"text":"risky, a \\(20- mm Hg\\) lower SBP goal (and/or a 10 mm Hg lower DBP goal) would likely","text_display":" risky, a \\(20- mm Hg\\) lower SBP goal (and/or a 10 mm Hg lower DBP goal) would likely","confidence":0.7188081741333008,"confidence_rate":0.9965667326844346},{"cnt":[[305,1964],[1811,1964],[1811,2011],[305,2011]],"region":{"top_left_x":305,"top_left_y":1963,"width":1507,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1077c3df8cd3415e80ad101e3812b704","type":"text","conversion_output":true,"text":"mean that up to \\(70-80\\) million Americans now 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Conclusion}","confidence":1,"confidence_rate":1},{"cnt":[[305,2402],[1798,2402],[1798,2451],[305,2451]],"region":{"top_left_x":305,"top_left_y":2401,"width":1494,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b60cab149f746f88ff6374a76e4f383","type":"text","conversion_output":true,"text":"If the SPRINT results are positive and support a SBP goal \\(<120 mm Hg\\), and this is fully","text_display":"\n\nIf the SPRINT results are positive and support a SBP goal \\(<120 mm Hg\\), and this is fully","confidence":1,"confidence_rate":1},{"cnt":[[305,2445],[1764,2445],[1764,2494],[305,2494]],"region":{"top_left_x":305,"top_left_y":2444,"width":1459,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2ae0913b3d54f11862e658ab511b74b","type":"text","conversion_output":true,"text":"applied in practice a large number of major CVD could be prevented each year, in the","text_display":" applied in practice a large number of major CVD could be prevented each year, in the","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbf44dcdeed748a6b31b99da8019a49f","type":"page_info","conversion_output":false,"text":"Version 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If none of the major outcomes show harm from","text_display":" for most patients with elevated BP. 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A high risk population stands to benefit most in","text_display":" efficiently studied in high-risk individuals. A high risk population stands to benefit most in","confidence":1,"confidence_rate":1},{"cnt":[[305,872],[1717,872],[1717,922],[305,922]],"region":{"top_left_x":305,"top_left_y":872,"width":1412,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a73bc5f5643543be87f0f15b6efa20f6","type":"text","conversion_output":true,"text":"the sense that a greater number of events may be prevented per treated individual.","text_display":" the sense that a greater number of events may be prevented per treated individual.","confidence":1,"confidence_rate":1},{"cnt":[[305,920],[1772,920],[1772,965],[305,965]],"region":{"top_left_x":305,"top_left_y":919,"width":1468,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"933c1cf233cc4424aaf0016e0ca738e4","type":"text","conversion_output":true,"text":"Furthermore, results in a diverse high risk population will likely generalize to lower risk","text_display":" Furthermore, results in a diverse high risk population will likely generalize to lower risk","confidence":1,"confidence_rate":1},{"cnt":[[305,962],[1815,962],[1815,1008],[305,1008]],"region":{"top_left_x":305,"top_left_y":962,"width":1511,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06fad1c4dc4a4785be77e6ee1de44599","type":"text","conversion_output":true,"text":"populations, at least in terms of relative risk reduction. 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SPRINT will focus on three high risk groups: individuals with clinical CVD other","confidence":1,"confidence_rate":1},{"cnt":[[305,1091],[1729,1091],[1729,1141],[305,1141]],"region":{"top_left_x":305,"top_left_y":1091,"width":1425,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2b84ad733f340b2aa313e51c6fdc277","type":"text","conversion_output":true,"text":"than stroke, individuals with CKD (estimated glomerular filtration rate [eGFR] 20-59","text_display":" than stroke, individuals with CKD (estimated glomerular filtration rate [eGFR] 20-59","confidence":0.98828125,"confidence_rate":0.9998675598299396},{"cnt":[[305,1134],[1800,1134],[1800,1184],[305,1184]],"region":{"top_left_x":305,"top_left_y":1134,"width":1496,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbb9d4d9527740528b7ed32fbee3baab","type":"text","conversion_output":true,"text":"\\(ml / min / 1.73 m^{2}\\) ), and individuals without clinical CVD who have high estimated CVD risk","text_display":" \\(ml / min / 1.73 m^{2}\\) ), and individuals without clinical CVD who have high estimated CVD risk","confidence":0.9980475902557373,"confidence_rate":0.9999815632059917},{"cnt":[[305,1182],[1798,1182],[1798,1227],[305,1227]],"region":{"top_left_x":305,"top_left_y":1181,"width":1494,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f526d5268154d2f9766b750e12c9af8","type":"text","conversion_output":true,"text":"based on factors such as smoking, low levels of HDL, high levels of LDL or age. Three","text_display":" based on factors such as smoking, low levels of HDL, high levels of LDL or age. Three","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[305,1225],[1734,1225],[1734,1274],[305,1274]],"region":{"top_left_x":305,"top_left_y":1224,"width":1429,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c663343b6f14f57aa93914210734584","type":"text","conversion_output":true,"text":"other groups will be excluded: patients with diabetes, patients with polycystic kidney","text_display":" other groups will be excluded: patients with diabetes, patients with polycystic kidney","confidence":1,"confidence_rate":1},{"cnt":[[305,1268],[1790,1268],[1790,1317],[305,1317]],"region":{"top_left_x":305,"top_left_y":1267,"width":1485,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0f39788f1b94751b70cc9a6b891f48f","type":"text","conversion_output":true,"text":"disease (PKD), and patients who have had a stroke. Patients with diabetes have been","text_display":" disease (PKD), and patients who have had a stroke. Patients with diabetes have been","confidence":1,"confidence_rate":1},{"cnt":[[305,1315],[1678,1315],[1678,1360],[305,1360]],"region":{"top_left_x":305,"top_left_y":1314,"width":1373,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd767dde2ae44a08ac3d4dd830700557","type":"text","conversion_output":true,"text":"studied in the ACCORD trial; patients with prior stroke and PKD are part of other","text_display":" studied in the ACCORD trial; patients with prior stroke and PKD are part of other","confidence":0.9951171875,"confidence_rate":0.9999430856618134},{"cnt":[[305,1358],[552,1358],[552,1405],[305,1405]],"region":{"top_left_x":305,"top_left_y":1357,"width":248,"height":49},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79e1586f6db643fb8c18c9d95f95d2f1","type":"text","conversion_output":true,"text":"ongoing trials.","text_display":" ongoing trials.","confidence":1,"confidence_rate":1},{"cnt":[[301,1439],[973,1439],[973,1497],[301,1497]],"region":{"top_left_x":300,"top_left_y":1439,"width":674,"height":59},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"716ce556a9a5453aa31dd5edbf98e4dd","type":"section_header","conversion_output":false,"children_ids":["a86b030decdc4abba771ce5b48b14f3e"],"text":"","text_display":""},{"cnt":[[305,1444],[969,1444],[969,1493],[305,1493]],"region":{"top_left_x":305,"top_left_y":1443,"width":664,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a86b030decdc4abba771ce5b48b14f3e","type":"text","conversion_output":true,"parent_id":"716ce556a9a5453aa31dd5edbf98e4dd","text":"1.2.1 Chronic Kidney Disease (CKD)","text_display":"\n\n\\subsection*{1.2.1 Chronic Kidney Disease (CKD)}","confidence":1,"confidence_rate":1},{"cnt":[[305,1538],[1721,1538],[1721,1583],[305,1583]],"region":{"top_left_x":305,"top_left_y":1538,"width":1416,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80129e051e4a48229c96a592605caac5","type":"text","conversion_output":true,"text":"An important and under-studied high-risk group for CVD is the population with CKD","text_display":"\n\nAn important and under-studied high-risk group for CVD is the population with CKD","confidence":1,"confidence_rate":1},{"cnt":[[305,1581],[1783,1581],[1783,1626],[305,1626]],"region":{"top_left_x":305,"top_left_y":1581,"width":1479,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b618e02cdf14cedafdd7f8675ca60cb","type":"text","conversion_output":true,"text":"(Coca and others, 2006). 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In the U.S., the number of persons with Stage 3 CKD (eGFR","confidence":0.9975595474243164,"confidence_rate":0.9999728510870505},{"cnt":[[305,1620],[1803,1620],[1803,1671],[305,1671]],"region":{"top_left_x":305,"top_left_y":1619,"width":1498,"height":53},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e70ca26afd804cab8f5b21ec741c8b03","type":"text","conversion_output":true,"text":"between 30 and \\(60 ml / min / 1.73 m^{2}\\) ) has recently been estimated to be \\(7.7 \\%\\) of the adult","text_display":" between 30 and \\(60 ml / min / 1.73 m^{2}\\) ) has recently been estimated to be \\(7.7 \\%\\) of the adult","confidence":0.95654296875,"confidence_rate":0.9996103428815454},{"cnt":[[305,1667],[1811,1667],[1811,1714],[305,1714]],"region":{"top_left_x":305,"top_left_y":1667,"width":1507,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66e40e02ac1d429892354074b5cbdb02","type":"text","conversion_output":true,"text":"population, or 15.5 million (Coresh and others, 2007). Patients with prevalent CVD have","text_display":" population, or 15.5 million (Coresh and others, 2007). Patients with prevalent CVD have","confidence":1,"confidence_rate":1},{"cnt":[[305,1712],[1648,1712],[1648,1760],[305,1760]],"region":{"top_left_x":305,"top_left_y":1712,"width":1343,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29933f1bc4f6497c99cb2b37877bf8c5","type":"text","conversion_output":true,"text":"a high prevalence of CKD, with reported ranges of \\(30-60 \\%\\) (Keeley and others,","text_display":" a high prevalence of CKD, with reported ranges of \\(30-60 \\%\\) (Keeley and others,","confidence":0.9970715045928955,"confidence_rate":0.9999650864209231},{"cnt":[[305,1757],[1268,1757],[1268,1807],[305,1807]],"region":{"top_left_x":305,"top_left_y":1757,"width":963,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fa946fdb462409297cf2f30afe6f3c9","type":"text","conversion_output":true,"text":"2003;Levey and others, 1998;Shlipak and others, 2002).","text_display":" 2003;Levey and others, 1998;Shlipak and others, 2002).","confidence":0.9658832550048828,"confidence_rate":0.9994118288692188},{"cnt":[[305,1843],[1781,1843],[1781,1893],[305,1893]],"region":{"top_left_x":305,"top_left_y":1843,"width":1477,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99afabd7bbba45db934826fff6e419a2","type":"text","conversion_output":true,"text":"Individuals with CKD are at high risk for CVD events (Shlipak and others, 2009;Go and","text_display":"\n\nIndividuals with CKD are at high risk for CVD events (Shlipak and others, 2009;Go and","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[305,1886],[1729,1886],[1729,1936],[305,1936]],"region":{"top_left_x":305,"top_left_y":1886,"width":1425,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78abb50dc0374e47a44dca03bc6cc9e8","type":"text","conversion_output":true,"text":"others, 2004;Rahman and others, 2006;Weiner and others, 2004;Foster and others,","text_display":" others, 2004;Rahman and others, 2006;Weiner and others, 2004;Foster and others,","confidence":0.94189453125,"confidence_rate":0.9992876113306502},{"cnt":[[305,1931],[1815,1931],[1815,1979],[305,1979]],"region":{"top_left_x":305,"top_left_y":1931,"width":1511,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c33a64b8bcdb47d6a47d4dbfe39232ea","type":"text","conversion_output":true,"text":"2007;McCullough and others, 2007;Rashidi and others, 2008;Fried and others, 2009). A","text_display":" 2007;McCullough and others, 2007;Rashidi and others, 2008;Fried and others, 2009). A","confidence":0.862044095993042,"confidence_rate":0.9983334256262206},{"cnt":[[305,1977],[1656,1977],[1656,2022],[305,2022]],"region":{"top_left_x":305,"top_left_y":1976,"width":1352,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0519f54c8f7c4c68883d8447eeaafa78","type":"text","conversion_output":true,"text":"meta-analysis of reported data from prospective studies in Western populations","text_display":" meta-analysis of reported data from prospective studies in Western populations","confidence":1,"confidence_rate":1},{"cnt":[[305,2015],[1800,2015],[1800,2067],[305,2067]],"region":{"top_left_x":305,"top_left_y":2015,"width":1496,"height":52},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb417568f0fd4cac9bb4361822770f7b","type":"text","conversion_output":true,"text":"demonstrated that people with an eGFR of \\(<60 ml / min / 1.73 m^{2}\\) have a relative risk of 1.4","text_display":" demonstrated that people with an eGFR of \\(<60 ml / min / 1.73 m^{2}\\) have a relative risk of 1.4","confidence":0.998046875,"confidence_rate":0.9999818979894378},{"cnt":[[305,2058],[1772,2058],[1772,2110],[305,2110]],"region":{"top_left_x":305,"top_left_y":2058,"width":1468,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1044a9c73fb743f6a9d77777ae890e9d","type":"text","conversion_output":true,"text":"for CVD, compared to those with an eGFR of \\(\\geq 60 ml / min / 1.73 m^{2}\\) (Di Angelantonio and","text_display":" for CVD, compared to those with an eGFR of \\(\\geq 60 ml / min / 1.73 m^{2}\\) (Di Angelantonio and","confidence":0.9985356330871582,"confidence_rate":0.9999859093286404},{"cnt":[[305,2110],[1725,2110],[1725,2155],[305,2155]],"region":{"top_left_x":305,"top_left_y":2109,"width":1421,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8197ec2edc14d13a6d37762310a2441","type":"text","conversion_output":true,"text":"others, 2007). The relative risk increases as eGFR declines (Go and others, 2004).","text_display":" others, 2007). The relative risk increases as eGFR declines (Go and others, 2004).","confidence":1,"confidence_rate":1},{"cnt":[[305,2153],[1768,2153],[1768,2198],[305,2198]],"region":{"top_left_x":305,"top_left_y":2152,"width":1464,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a60960cb05e48b6a3a5052fd8b4ca77","type":"text","conversion_output":true,"text":"Pooled data from the ARIC and CHS cohorts demonstrated that participants with CKD","text_display":" Pooled data from the ARIC and CHS cohorts demonstrated that participants with CKD","confidence":1,"confidence_rate":1},{"cnt":[[305,2196],[1755,2196],[1755,2243],[305,2243]],"region":{"top_left_x":305,"top_left_y":2195,"width":1451,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0167862b83b4d79a1d3656ae0337b80","type":"text","conversion_output":true,"text":"were also at increased risk for stroke (Weiner and others, 2007), and CKD was a risk","text_display":" were also at increased risk for stroke (Weiner and others, 2007), and CKD was a risk","confidence":1,"confidence_rate":1},{"cnt":[[305,2239],[1678,2239],[1678,2288],[305,2288]],"region":{"top_left_x":305,"top_left_y":2238,"width":1373,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"731ad7d3146a4516b956a0d46ccc6021","type":"text","conversion_output":true,"text":"factor for CVD and all-cause mortality independent of traditional CVD risk factors","text_display":" factor for CVD and all-cause mortality independent of traditional CVD risk factors","confidence":1,"confidence_rate":1},{"cnt":[[305,2282],[1768,2282],[1768,2331],[305,2331]],"region":{"top_left_x":305,"top_left_y":2281,"width":1464,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66e5e88da0ef4ffcbf78a8ebefe3c7e6","type":"text","conversion_output":true,"text":"(Weiner and others, 2004). In ALLHAT, despite exclusion criteria designed to exclude","text_display":" (Weiner and others, 2004). In ALLHAT, despite exclusion criteria designed to exclude","confidence":1,"confidence_rate":1},{"cnt":[[305,2329],[1757,2329],[1757,2374],[305,2374]],"region":{"top_left_x":305,"top_left_y":2328,"width":1453,"height":47},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24178b4b12ce4fa5a9344968cff2bbcf","type":"text","conversion_output":true,"text":"participants with significant GFR impairment, about \\(18 \\%\\) of participants had an eGFR","text_display":" participants with significant GFR impairment, about \\(18 \\%\\) of participants had an eGFR","confidence":0.9014151096343994,"confidence_rate":0.9988601072437662},{"cnt":[[305,2365],[1796,2365],[1796,2417],[305,2417]],"region":{"top_left_x":305,"top_left_y":2365,"width":1492,"height":52},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb113141a7e94bee98f71877a4641fa9","type":"text","conversion_output":true,"text":"\\(30-60 ml / min / 1.73 m^{2}\\). In that CKD subgroup, CHD was \\(38 \\%\\) higher and combined CVD","text_display":" \\(30-60 ml / min / 1.73 m^{2}\\). In that CKD subgroup, CHD was \\(38 \\%\\) higher and combined CVD","confidence":1,"confidence_rate":1},{"cnt":[[305,2411],[1798,2411],[1798,2464],[305,2464]],"region":{"top_left_x":305,"top_left_y":2410,"width":1494,"height":55},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03326f28bbcd48c3b86d355068dbb55b","type":"text","conversion_output":true,"text":"\\(35 \\%\\) higher than in those with an eGFR \\(>90 ml / min / 1.73 m^{2}\\) (Rahman and others, 2006).","text_display":" \\(35 \\%\\) higher than in those with an eGFR \\(>90 ml / min / 1.73 m^{2}\\) (Rahman and others, 2006).","confidence":1,"confidence_rate":1},{"cnt":[[305,2636],[492,2636],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2636,"width":187,"height":39},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1e869605ccf4c3e91a1e37964127f92","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1048,2638],[1079,2638],[1079,2679],[1048,2679]],"region":{"top_left_x":1048,"top_left_y":2638,"width":31,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9237fb88e1a0493da3f8f974556cd83e","type":"page_info","conversion_output":false,"text":"8","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2677],[1521,2677]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":44},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74b60290204543a29e87163db87b1b6c","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-011","page":11,"lines":[{"cnt":[[305,249],[1749,249],[1749,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1444,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0eff6974c2424bdda76795e849d707fb","type":"text","conversion_output":true,"text":"The effect of BP control on the development of CVD in the CKD population is far less","text_display":"\n\nThe effect of BP control on the development of CVD in the CKD population is far less","confidence":0.9990236759185791,"confidence_rate":0.999989024768136},{"cnt":[[305,296],[810,296],[810,346],[305,346]],"region":{"top_left_x":305,"top_left_y":296,"width":505,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7396b29b394647a1a62451c62edb82ec","type":"text","conversion_output":true,"text":"clear (Berl and others, 2005).","text_display":" clear (Berl and others, 2005).","confidence":1,"confidence_rate":1},{"cnt":[[305,380],[1790,380],[1790,428],[305,428]],"region":{"top_left_x":305,"top_left_y":380,"width":1485,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04c3dbbcd2f2476c962964d81af27576","type":"text","conversion_output":true,"text":"A strategy of treating to a lower BP goal may reduce the progression of kidney disease.","text_display":"\n\nA strategy of treating to a lower BP goal may reduce the progression of kidney disease.","confidence":1,"confidence_rate":1},{"cnt":[[305,423],[1764,423],[1764,471],[305,471]],"region":{"top_left_x":305,"top_left_y":423,"width":1459,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a65f7d513f046f7a5517a47af0452b8","type":"text","conversion_output":true,"text":"The risk of CKD increases progressively beginning with pre-HTN levels of BP through","text_display":" The risk of CKD increases progressively beginning with pre-HTN levels of BP through","confidence":1,"confidence_rate":1},{"cnt":[[305,468],[1751,468],[1751,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1446,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aebc96e83e894f378a12b3579d22d60d","type":"text","conversion_output":true,"text":"the various stages of HTN (Haroun and others, 2003). Several observational studies","text_display":" the various stages of HTN (Haroun and others, 2003). Several observational studies","confidence":1,"confidence_rate":1},{"cnt":[[305,511],[1766,511],[1766,561],[305,561]],"region":{"top_left_x":305,"top_left_y":511,"width":1462,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b17d1f35fb74ac1a848f2bcd3e57908","type":"text","conversion_output":true,"text":"have suggested that achievement of lower BP is associated with lower risk of adverse","text_display":" have suggested that achievement of lower BP is associated with lower risk of adverse","confidence":1,"confidence_rate":1},{"cnt":[[305,554],[1811,554],[1811,604],[305,604]],"region":{"top_left_x":305,"top_left_y":554,"width":1507,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7af05f87bb34912b2837c4d564b3cda","type":"text","conversion_output":true,"text":"kidney outcomes (Bakris and others, 2000;Klag and others, 1996;Schaeffner and others,","text_display":" kidney outcomes (Bakris and others, 2000;Klag and others, 1996;Schaeffner and others,","confidence":0.99658203125,"confidence_rate":0.9999619582419443},{"cnt":[[305,597],[1755,597],[1755,647],[305,647]],"region":{"top_left_x":305,"top_left_y":597,"width":1451,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26538d99e4a24338866b45054083b1a0","type":"text","conversion_output":true,"text":"2008). However, two randomized clinical trials, AASK and the Modification of Diet in","text_display":" 2008). However, two randomized clinical trials, AASK and the Modification of Diet in","confidence":1,"confidence_rate":1},{"cnt":[[305,642],[1779,642],[1779,692],[305,692]],"region":{"top_left_x":305,"top_left_y":642,"width":1474,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e075c5412d4c4bf8ae81d12c7f0295c0","type":"text","conversion_output":true,"text":"Renal Disease Study (MDRD) that examined lower-than-usual BP goals failed to show","text_display":" Renal Disease Study (MDRD) that examined lower-than-usual BP goals failed to show","confidence":1,"confidence_rate":1},{"cnt":[[305,688],[1811,688],[1811,737],[305,737]],"region":{"top_left_x":305,"top_left_y":687,"width":1507,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2ed5d484105470690d9145c64e1d5ee","type":"text","conversion_output":true,"text":"an overall significant beneficial long-term effect of lower BP on decline in kidney function","text_display":" an overall significant beneficial long-term effect of lower BP on decline in kidney function","confidence":1,"confidence_rate":1},{"cnt":[[305,730],[1815,730],[1815,780],[305,780]],"region":{"top_left_x":305,"top_left_y":730,"width":1511,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1eae486a2f2143d089cc7997875b7421","type":"text","conversion_output":true,"text":"(Klahr and others, 1994;Wright, Jr. and others, 2002b) Both studies enrolled participants","text_display":" (Klahr and others, 1994;Wright, Jr. and others, 2002b) Both studies enrolled participants","confidence":1,"confidence_rate":1},{"cnt":[[305,776],[1792,776],[1792,823],[305,823]],"region":{"top_left_x":305,"top_left_y":775,"width":1487,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc77be3ba9864bf3b1c3db13b49e2d9b","type":"text","conversion_output":true,"text":"with non-diabetic CKD and randomized them to a mean arterial pressure (MAP) goal of","text_display":" with non-diabetic CKD and randomized them to a mean arterial pressure (MAP) goal of","confidence":1,"confidence_rate":1},{"cnt":[[305,819],[1648,819],[1648,870],[305,870]],"region":{"top_left_x":305,"top_left_y":818,"width":1343,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d6ffd8df86544f0b88e72dc636fdf53","type":"text","conversion_output":true,"text":"\\(<92 mm Hg\\) (corresponding to \\(<125 / 75 mm Hg\\) ) or a MAP goal of \\(<107 mm Hg\\)","text_display":" \\(<92 mm Hg\\) (corresponding to \\(<125 / 75 mm Hg\\) ) or a MAP goal of \\(<107 mm Hg\\)","confidence":0.9892718747723848,"confidence_rate":0.9998700555943549},{"cnt":[[305,864],[1777,864],[1777,913],[305,913]],"region":{"top_left_x":305,"top_left_y":863,"width":1472,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8c3ab825d394924b2e82e5925b8ae3a","type":"text","conversion_output":true,"text":"(corresponding to \\(<140 / 90 mm Hg\\) ). The AASK trial compared two BP goals based on","text_display":" (corresponding to \\(<140 / 90 mm Hg\\) ). The AASK trial compared two BP goals based on","confidence":0.9965834617614746,"confidence_rate":0.9999619741904117},{"cnt":[[305,907],[1732,907],[1732,956],[305,956]],"region":{"top_left_x":305,"top_left_y":906,"width":1427,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50f62c3b4abf4632b9497497e9f2a11d","type":"text","conversion_output":true,"text":"MAP (102-107 vs. \\(<92 mm Hg\\) ) in 1094 African Americans with hypertensive kidney","text_display":" MAP (102-107 vs. \\(<92 mm Hg\\) ) in 1094 African Americans with hypertensive kidney","confidence":0.909256663469316,"confidence_rate":0.9989665358422095},{"cnt":[[305,950],[1794,950],[1794,999],[305,999]],"region":{"top_left_x":305,"top_left_y":949,"width":1489,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4330c66d63304bd9b73c12016c647b5c","type":"text","conversion_output":true,"text":"disease; the achieved difference of 128/78 vs. 141/85 did not reduce the progression of","text_display":" disease; the achieved difference of 128/78 vs. 141/85 did not reduce the progression of","confidence":0.98486328125,"confidence_rate":0.9998342262614938},{"cnt":[[305,993],[1777,993],[1777,1042],[305,1042]],"region":{"top_left_x":305,"top_left_y":992,"width":1472,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b881d6746d6e40919aeeb43880bd1399","type":"text","conversion_output":true,"text":"CKD (Wright, Jr. and others, 2002b). However, subgroup analyses of long-term (up to","text_display":" CKD (Wright, Jr. and others, 2002b). However, subgroup analyses of long-term (up to","confidence":1,"confidence_rate":1},{"cnt":[[305,1038],[1725,1038],[1725,1087],[305,1087]],"region":{"top_left_x":305,"top_left_y":1037,"width":1421,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eff19327204a46dba77eb2d95a6f942c","type":"text","conversion_output":true,"text":"10 years) post trial follow-up suggested the possibility of benefit in participants with","text_display":" 10 years) post trial follow-up suggested the possibility of benefit in participants with","confidence":1,"confidence_rate":1},{"cnt":[[305,1083],[1766,1083],[1766,1130],[305,1130]],"region":{"top_left_x":305,"top_left_y":1082,"width":1462,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fc52c78297c463f9121297c66a3610c","type":"text","conversion_output":true,"text":"baseline urinary protein excretion equivalent to \\(>300 mg /\\) day who were randomized to","text_display":" baseline urinary protein excretion equivalent to \\(>300 mg /\\) day who were randomized to","confidence":0.86328125,"confidence_rate":0.9984372357624817},{"cnt":[[305,1126],[1717,1126],[1717,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1125,"width":1412,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e96dac251a84e97b6c7c847a0e24f31","type":"text","conversion_output":true,"text":"the lower goal (Appel and others, 2008). Among 585 non-diabetic participants with","text_display":" the lower goal (Appel and others, 2008). Among 585 non-diabetic participants with","confidence":1,"confidence_rate":1},{"cnt":[[305,1171],[1790,1171],[1790,1218],[305,1218]],"region":{"top_left_x":305,"top_left_y":1170,"width":1485,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e017a0b82b64f17903fbcb434af5336","type":"text","conversion_output":true,"text":"Stage \\(3 / 4\\) CKD in MDRD, \\(24 \\%\\) had PKD and only 53 were African American (Klahr and","text_display":" Stage \\(3 / 4\\) CKD in MDRD, \\(24 \\%\\) had PKD and only 53 were African American (Klahr and","confidence":0.5812478065490723,"confidence_rate":0.994182812666327},{"cnt":[[305,1216],[1721,1216],[1721,1263],[305,1263]],"region":{"top_left_x":305,"top_left_y":1216,"width":1416,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24d588d6db884ceb8b02f47b42bb4c9e","type":"text","conversion_output":true,"text":"others, 1994). Mean baseline proteinuria was \\(2.2 g / d\\), and a beneficial effect of the","text_display":" others, 1994). Mean baseline proteinuria was \\(2.2 g / d\\), and a beneficial effect of the","confidence":1,"confidence_rate":1},{"cnt":[[305,1259],[1682,1259],[1682,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1258,"width":1378,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f67f155e3dad4fe581963a5df6f608d6","type":"text","conversion_output":true,"text":"lower BP goal on GFR was observed in the subgroup with urinary protein \\(>1 g / d\\)","text_display":" lower BP goal on GFR was observed in the subgroup with urinary protein \\(>1 g / d\\)","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[305,1302],[1687,1302],[1687,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1301,"width":1382,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3c35bfc44804a4c8f8b6582bee91c60","type":"text","conversion_output":true,"text":"(Peterson and others, 1995;Sarnak and others, 2005). 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Together, these studies fail to show convincing renoprotective effects","text_display":" (ACE) inhibitors. Together, these studies fail to show convincing renoprotective effects","confidence":1,"confidence_rate":1},{"cnt":[[305,1521],[1760,1521],[1760,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1521,"width":1455,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9d004821cfd42c0b17bbded6386ca30","type":"text","conversion_output":true,"text":"for the lower BP goal; however their results have led to clinical recommendations that","text_display":" for the lower BP goal; however their results have led to clinical recommendations that","confidence":1,"confidence_rate":1},{"cnt":[[305,1566],[1775,1566],[1775,1613],[305,1613]],"region":{"top_left_x":305,"top_left_y":1566,"width":1470,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43209112023c474aba6450204bd1eb45","type":"text","conversion_output":true,"text":"patients with high levels of proteinuria should have blood pressure goals below 140/90","text_display":" patients with high levels of proteinuria should have blood pressure goals below 140/90","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1777,1611],[1777,1656],[305,1656]],"region":{"top_left_x":305,"top_left_y":1611,"width":1472,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1412c305997c41b0be365f00a374b786","type":"text","conversion_output":true,"text":"mm Hg . They were not adequately powered to consider CVD outcomes. Nonetheless,","text_display":" mm Hg . They were not adequately powered to consider CVD outcomes. Nonetheless,","confidence":0.97265625,"confidence_rate":0.9996776734930649},{"cnt":[[305,1654],[1807,1654],[1807,1702],[305,1702]],"region":{"top_left_x":305,"top_left_y":1654,"width":1502,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9686a894af0c491183d03dc3e7384cf8","type":"text","conversion_output":true,"text":"they successfully demonstrated the feasibility of achieving significant separation in BP in","text_display":" they successfully demonstrated the feasibility of achieving significant separation in BP in","confidence":1,"confidence_rate":1},{"cnt":[[305,1697],[1777,1697],[1777,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1697,"width":1472,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fcf901249294f059070571977707539","type":"text","conversion_output":true,"text":"large cohorts with advanced CKD. Given the rapid increase in the prevalence of CKD,","text_display":" large cohorts with advanced CKD. Given the rapid increase in the prevalence of CKD,","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[305,1740],[1783,1740],[1783,1790],[305,1790]],"region":{"top_left_x":305,"top_left_y":1740,"width":1479,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50dc371632d046089dc7c563a60082c9","type":"text","conversion_output":true,"text":"the effects of aggressively lowering BP on the risks of CVD and CKD progression need","text_display":" the effects of aggressively lowering BP on the risks of CVD and CKD progression need","confidence":1,"confidence_rate":1},{"cnt":[[305,1783],[1691,1783],[1691,1833],[305,1833]],"region":{"top_left_x":305,"top_left_y":1783,"width":1386,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a87c89f363a24271a360f6905f8a97f8","type":"text","conversion_output":true,"text":"to be clarified in a sample that appropriately mirrors the U.S. population with CKD","text_display":" to be clarified in a sample that appropriately mirrors the U.S. population with CKD","confidence":0.9677734375,"confidence_rate":0.9996278275543817},{"cnt":[[305,1830],[771,1830],[771,1878],[305,1878]],"region":{"top_left_x":305,"top_left_y":1830,"width":467,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46a2c7f31d104837b7573324d0037b5e","type":"text","conversion_output":true,"text":"(Sarnak and others, 2003).","text_display":" (Sarnak and others, 2003).","confidence":1,"confidence_rate":1},{"cnt":[[303,1912],[1130,1912],[1130,1970],[303,1970]],"region":{"top_left_x":302,"top_left_y":1912,"width":829,"height":59},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73aad8f2662641b6854d68728f57ee9e","type":"section_header","conversion_output":false,"children_ids":["23eead78e6804a2c81e6ae116dbd5fa3"],"text":"","text_display":""},{"cnt":[[305,1916],[1126,1916],[1126,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1916,"width":821,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23eead78e6804a2c81e6ae116dbd5fa3","type":"text","conversion_output":true,"parent_id":"73aad8f2662641b6854d68728f57ee9e","text":"1.2.2 SENIOR participants and SPRINT-MIND","text_display":"\n\n\\subsection*{1.2.2 SENIOR participants and SPRINT-MIND}","confidence":1,"confidence_rate":1},{"cnt":[[305,2004],[1674,2004],[1674,2052],[305,2052]],"region":{"top_left_x":305,"top_left_y":2004,"width":1369,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27521d00f1464150a9aea957b07f9996","type":"text","conversion_output":true,"text":"Including a large subgroup of participants aged \\(75+\\) will provide data on whether","text_display":"\n\nIncluding a large subgroup of participants aged \\(75+\\) will provide data on whether","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[305,2050],[1678,2050],[1678,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2049,"width":1373,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41cdd89851d04238b5d4dcd665b099d4","type":"text","conversion_output":true,"text":"intensive BP treatment will reduce CVD and renal events in the elderly. Both the","text_display":" intensive BP treatment will reduce CVD and renal events in the elderly. Both the","confidence":1,"confidence_rate":1},{"cnt":[[305,2093],[1721,2093],[1721,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2092,"width":1416,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a3f683edfa541cfa3212834995e0599","type":"text","conversion_output":true,"text":"Treatment of Hypertension in Patients over 80 Years of Age (HYVET) (Beckett and","text_display":" Treatment of Hypertension in Patients over 80 Years of Age (HYVET) (Beckett and","confidence":1,"confidence_rate":1},{"cnt":[[305,2136],[1747,2136],[1747,2185],[305,2185]],"region":{"top_left_x":305,"top_left_y":2135,"width":1442,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9f59fd1b6f3422e932c40f0ce679664","type":"text","conversion_output":true,"text":"others, 2008) and the SHEP (SHEP, 1991) trials found that a SBP delta of 15 and 11","text_display":" others, 2008) and the SHEP (SHEP, 1991) trials found that a SBP delta of 15 and 11","confidence":1,"confidence_rate":1},{"cnt":[[305,2179],[1811,2179],[1811,2228],[305,2228]],"region":{"top_left_x":305,"top_left_y":2178,"width":1507,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dde5e06a820e475abc56bfb62d395ba2","type":"text","conversion_output":true,"text":"mm Hg , respectively, between treated and placebo groups resulted in \\(>30 \\%\\) reduction in","text_display":" mm Hg , respectively, between treated and placebo groups resulted in \\(>30 \\%\\) reduction in","confidence":0.996584415435791,"confidence_rate":0.9999643607289522},{"cnt":[[305,2226],[1751,2226],[1751,2271],[305,2271]],"region":{"top_left_x":305,"top_left_y":2225,"width":1446,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8ca01e268e24d79a35dc76639867cef","type":"text","conversion_output":true,"text":"stroke, HF, and overall CVD events in the treated groups. Unlike HYVET and SHEP,","text_display":" stroke, HF, and overall CVD events in the treated groups. Unlike HYVET and SHEP,","confidence":1,"confidence_rate":1},{"cnt":[[305,2269],[1794,2269],[1794,2316],[305,2316]],"region":{"top_left_x":305,"top_left_y":2268,"width":1489,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7395fd37d3e8408a847034de27948750","type":"text","conversion_output":true,"text":"which had SBP levels of about 150 and 143 mm Hg at the end of the trials, SPRINT will","text_display":" which had SBP levels of about 150 and 143 mm Hg at the end of the trials, SPRINT will","confidence":0.9956073760986328,"confidence_rate":0.9999550795822252},{"cnt":[[305,2312],[1811,2312],[1811,2361],[305,2361]],"region":{"top_left_x":305,"top_left_y":2311,"width":1507,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c11b85f099334f4eafc8e2e31d296284","type":"text","conversion_output":true,"text":"have a substantially lower SBP target of \\(<120 mm Hg\\) in the intensive treatment group, a","text_display":" have a substantially lower SBP target of \\(<120 mm Hg\\) in the intensive treatment group, a","confidence":0.9960966110229492,"confidence_rate":0.9999596809460038},{"cnt":[[305,2357],[1691,2357],[1691,2404],[305,2404]],"region":{"top_left_x":305,"top_left_y":2356,"width":1386,"height":49},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"766f541549544efebe142a29eedfc8f1","type":"text","conversion_output":true,"text":"goal which has never been tested in the elderly. No previous large scale trial has","text_display":" goal which has never been tested in the elderly. No previous large scale trial has","confidence":1,"confidence_rate":1},{"cnt":[[305,2400],[1800,2400],[1800,2447],[305,2447]],"region":{"top_left_x":305,"top_left_y":2399,"width":1496,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a7c1df48abf451fbdf2dd9ced0b36df","type":"text","conversion_output":true,"text":"examined the impact of treating SBP in the elderly to \\(<120 mm Hg\\) versus \\(<140 mm Hg\\).","text_display":" examined the impact of treating SBP in the elderly to \\(<120 mm Hg\\) versus \\(<140 mm Hg\\).","confidence":0.8125913143157959,"confidence_rate":0.9979059633961699},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64893eff314d48c284ceefdce930c824","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1048,2638],[1079,2638],[1079,2679],[1048,2679]],"region":{"top_left_x":1048,"top_left_y":2638,"width":31,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e16e0682db7f4d559a5f7d34b5fddce4","type":"page_info","conversion_output":false,"text":"9","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2677],[1521,2677]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":44},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee525f935f87434ab698c01cea4b1e2c","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-012","page":12,"lines":[{"cnt":[[309,251],[1738,251],[1738,299],[309,299]],"region":{"top_left_x":309,"top_left_y":251,"width":1430,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3ed79cfa955407b9db240aa8abfaf00","type":"text","conversion_output":true,"text":"Importantly, the elderly pose an additional question as to the safety of intensive SBP","text_display":"\n\nImportantly, the elderly pose an additional question as to the safety of intensive SBP","confidence":1,"confidence_rate":1},{"cnt":[[309,296],[1794,296],[1794,342],[309,342]],"region":{"top_left_x":309,"top_left_y":296,"width":1485,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21b4360ca90d47cb80811102921f1c6a","type":"text","conversion_output":true,"text":"lowering in a population with known wider pulse pressures and a risk of excessively low","text_display":" lowering in a population with known wider pulse pressures and a risk of excessively low","confidence":1,"confidence_rate":1},{"cnt":[[309,339],[1807,339],[1807,387],[309,387]],"region":{"top_left_x":309,"top_left_y":339,"width":1498,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a4f8ac1578f4fb3904358a5baeb9730","type":"text","conversion_output":true,"text":"DBP with intensive SBP treatment. In addition to concerns about hypotension, syncope,","text_display":" DBP with intensive SBP treatment. 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This is a specific concern related to very low DBP, which","text_display":" detrimental in the elderly. This is a specific concern related to very low DBP, which","confidence":1,"confidence_rate":1},{"cnt":[[309,473],[1811,473],[1811,518],[309,518]],"region":{"top_left_x":309,"top_left_y":472,"width":1503,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52fd5c50b85a4404afe77180c12d382c","type":"text","conversion_output":true,"text":"could compromise coronary blood flow. The SPRINT-Senior cohort will allow us to more","text_display":" could compromise coronary blood flow. The SPRINT-Senior cohort will allow us to more","confidence":1,"confidence_rate":1},{"cnt":[[309,516],[1160,516],[1160,561],[309,561]],"region":{"top_left_x":309,"top_left_y":515,"width":852,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a3fcb7e73f243a8a8d059391f003ecb","type":"text","conversion_output":true,"text":"precisely assess the safety of the lower SBP goal.","text_display":" precisely assess the safety of the lower SBP goal.","confidence":1,"confidence_rate":1},{"cnt":[[309,602],[1652,602],[1652,649],[309,649]],"region":{"top_left_x":309,"top_left_y":601,"width":1344,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a6e5e5ba3db44eb9e42e23fccc0e8de","type":"text","conversion_output":true,"text":"The SPRINT Senior cohort also provides a critically important the main body of","text_display":"\n\nThe SPRINT Senior cohort also provides a critically important the main body of","confidence":0.9990234375,"confidence_rate":0.9999882285072625},{"cnt":[[309,647],[1777,647],[1777,694],[309,694]],"region":{"top_left_x":309,"top_left_y":646,"width":1468,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1e2e94eaec342eb9729a92f0dfdee83","type":"text","conversion_output":true,"text":"participants for SPRINT-MIND. Dementia is a leading cause of placement into nursing","text_display":" participants for SPRINT-MIND. 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Dementia affects 24","text_display":" 1997;Magsi and Malloy, 2005;National Institute on Aging, 2000). Dementia affects 24","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[309,778],[1785,778],[1785,827],[309,827]],"region":{"top_left_x":309,"top_left_y":777,"width":1477,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbf7d85d29fd4a41be0bbeea7267a652","type":"text","conversion_output":true,"text":"million individuals globally and 4.5 million persons in the US, a number that is expected","text_display":" million individuals globally and 4.5 million persons in the US, a number that is expected","confidence":1,"confidence_rate":1},{"cnt":[[307,821],[1777,821],[1777,870],[307,870]],"region":{"top_left_x":307,"top_left_y":820,"width":1470,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7938855c018447fabca4006c5194d64","type":"text","conversion_output":true,"text":"to double by 2040 (Ferri and others, 2005;Plassman and others, 2007). Both dementia","text_display":" to double by 2040 (Ferri and others, 2005;Plassman and others, 2007). 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With this strong link to CVD risk","confidence":0.99755859375,"confidence_rate":0.9999742698958483},{"cnt":[[305,1568],[1792,1568],[1792,1618],[305,1618]],"region":{"top_left_x":305,"top_left_y":1568,"width":1487,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dee3469369c04c39b36f6db61227793c","type":"text","conversion_output":true,"text":"plus several observational studies suggesting that the ideal SBP to lower CVD risk may","text_display":" plus several observational studies suggesting that the ideal SBP to lower CVD risk may","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1809,1611],[1809,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1504,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a30b5f687a654ffb8f9d3a731811953f","type":"text","conversion_output":true,"text":"be below 120 mm Hg (Chobanian and others, 2003) it is possible that targeting intensive","text_display":" be below 120 mm Hg (Chobanian and others, 2003) it is possible that targeting intensive","confidence":1,"confidence_rate":1},{"cnt":[[305,1656],[1613,1656],[1613,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1656,"width":1309,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c4aabab6d464f89b9d7bf25270f7353","type":"text","conversion_output":true,"text":"blood pressure control intensive blood pressure control may have substantial","text_display":" blood pressure control intensive blood pressure control may have substantial","confidence":1,"confidence_rate":1},{"cnt":[[305,1702],[1008,1702],[1008,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1701,"width":703,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c236152b3b6f443288c0555b195d519d","type":"text","conversion_output":true,"text":"implications for preserving brain function.","text_display":" implications for preserving brain function.","confidence":1,"confidence_rate":1},{"cnt":[[305,1788],[1794,1788],[1794,1837],[305,1837]],"region":{"top_left_x":305,"top_left_y":1787,"width":1489,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79c2732686404fd5b531ffafbbf267b2","type":"text","conversion_output":true,"text":"Substantial epidemiologic evidence identifies hypertension as a risk factor for dementia.","text_display":"\n\nSubstantial epidemiologic evidence identifies hypertension as a risk factor for dementia.","confidence":1,"confidence_rate":1},{"cnt":[[305,1833],[1790,1833],[1790,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1832,"width":1485,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44bfed8c13a64e2f9ae5731db09edeca","type":"text","conversion_output":true,"text":"Longitudinal observational studies have yielded mixed results, depending on the age at","text_display":" Longitudinal observational studies have yielded mixed results, depending on the age at","confidence":1,"confidence_rate":1},{"cnt":[[305,1878],[1747,1878],[1747,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1877,"width":1442,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82282873bb82429ea7902a4fecbef6a1","type":"text","conversion_output":true,"text":"which blood pressure is measured, the impact and duration of treatment, duration of","text_display":" which blood pressure is measured, the impact and duration of treatment, duration of","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1661,1921],[1661,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1356,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4784bafdd3a446c18ec5ff82e154ef3d","type":"text","conversion_output":true,"text":"hypertension, and level of BP control (Birns and others, 2006;Qiu, Winblad, and","text_display":" hypertension, and level of BP control (Birns and others, 2006;Qiu, Winblad, and","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[305,1964],[1661,1964],[1661,2013],[305,2013]],"region":{"top_left_x":305,"top_left_y":1963,"width":1356,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"655785fdfad648cf8c4b99bdfb19237c","type":"text","conversion_output":true,"text":"Fratiglioni, 2005). 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Studies using more sensitive neuropsychological","text_display":" general cognitive function at baseline. Studies using more sensitive neuropsychological","confidence":1,"confidence_rate":1},{"cnt":[[305,999],[1682,999],[1682,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":999,"width":1378,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92c00cffe0b8486caa9cfaa1a17a3cd4","type":"text","conversion_output":true,"text":"tests, such as the testing proposed for SPRINT-MIND, have shown the strongest","text_display":" tests, such as the testing proposed for SPRINT-MIND, have shown the strongest","confidence":1,"confidence_rate":1},{"cnt":[[305,1040],[1764,1040],[1764,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1459,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47169372207d42d0993a27dc9b8c7b53","type":"text","conversion_output":true,"text":"relationships (Elias and others, 1993;Kivipelto and others, 2001a;Kivipelto and others,","text_display":" relationships (Elias and others, 1993;Kivipelto and others, 2001a;Kivipelto and others,","confidence":1,"confidence_rate":1},{"cnt":[[305,1087],[913,1087],[913,1137],[305,1137]],"region":{"top_left_x":305,"top_left_y":1087,"width":609,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66f8b3529b214aeb9faf4527efbe87fa","type":"text","conversion_output":true,"text":"2001c;Knopman and others, 2001).","text_display":" 2001c;Knopman and others, 2001).","confidence":0.99951171875,"confidence_rate":0.9999868000736574},{"cnt":[[305,1173],[1742,1173],[1742,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1438,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28328d102cc646489b41652c91479fc8","type":"text","conversion_output":true,"text":"Hypertension is the primary risk factor for small vessel ischemic disease and cortical","text_display":"\n\nHypertension is the primary risk factor for small vessel ischemic disease and cortical","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[1751,1216],[1751,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1446,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f247ca672a40436ebc609f80641686a1","type":"text","conversion_output":true,"text":"white matter abnormalities (Basile and others, 2006;Kuller and others, 2010;Liao and","text_display":" white matter abnormalities (Basile and others, 2006;Kuller and others, 2010;Liao and","confidence":0.9980483050458702,"confidence_rate":0.9999780496567277},{"cnt":[[305,1261],[1631,1261],[1631,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1261,"width":1326,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"235bf611cda5497cad6b5f0c775b1467","type":"text","conversion_output":true,"text":"others, 1996;Longstreth, Jr. and others, 1996). Chronic kidney disease is also","text_display":" others, 1996;Longstreth, Jr. and others, 1996). Chronic kidney disease is also","confidence":0.99853515625,"confidence_rate":0.9999823384971409},{"cnt":[[305,1306],[1772,1306],[1772,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":1468,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09e1df2bc33c4cf6ad28c91f785fd419","type":"text","conversion_output":true,"text":"associated with white matter abnormalities (Ikram and others, 2008), thus the SPRINT","text_display":" associated with white matter abnormalities (Ikram and others, 2008), thus the SPRINT","confidence":0.9873046875,"confidence_rate":0.9998564531512621},{"cnt":[[305,1349],[1695,1349],[1695,1396],[305,1396]],"region":{"top_left_x":305,"top_left_y":1349,"width":1391,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f611372fed84db99ca127e7ba7585f5","type":"text","conversion_output":true,"text":"population is at high risk for significant white matter changes. Longitudinal studies","text_display":" population is at high risk for significant white matter changes. Longitudinal studies","confidence":1,"confidence_rate":1},{"cnt":[[305,1394],[1781,1394],[1781,1439],[305,1439]],"region":{"top_left_x":305,"top_left_y":1394,"width":1477,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57284bdcdfc74c15a31ec5e2c32e18f1","type":"text","conversion_output":true,"text":"document that hypertension-associated white matter abnormalities are an independent","text_display":" document that hypertension-associated white matter abnormalities are an independent","confidence":1,"confidence_rate":1},{"cnt":[[305,1435],[1779,1435],[1779,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1435,"width":1474,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae0a411ab0ea46428191a27beb23e60a","type":"text","conversion_output":true,"text":"risk factor for cognitive decline and dementia (Verdelho and others, 2007;Vermeer and","text_display":" risk factor for cognitive decline and dementia (Verdelho and others, 2007;Vermeer and","confidence":1,"confidence_rate":1},{"cnt":[[305,1480],[1781,1480],[1781,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1480,"width":1477,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c68121a529649ef80ebe66dd8ab0f2d","type":"text","conversion_output":true,"text":"others, 2003), lower extremity functional abnormalities (Rosano and others, 2005), and","text_display":" others, 2003), lower extremity functional abnormalities (Rosano and others, 2005), and","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1811,1525],[1811,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1525,"width":1507,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"946c7939aec44084a3bb176826aea157","type":"text","conversion_output":true,"text":"clinical stroke (Debette and others, 2010). However, there is limited evidence that better","text_display":" clinical stroke (Debette and others, 2010). However, there is limited evidence that better","confidence":1,"confidence_rate":1},{"cnt":[[305,1568],[1723,1568],[1723,1618],[305,1618]],"region":{"top_left_x":305,"top_left_y":1568,"width":1419,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"165fe905e04f47d5b15943ddfc4af314","type":"text","conversion_output":true,"text":"control of BP slows the progression of white matter lesions in the brain (Dufouil and","text_display":" control of BP slows the progression of white matter lesions in the brain (Dufouil and","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1740,1611],[1740,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1436,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc97a546000c42ceab4c176093dda90b","type":"text","conversion_output":true,"text":"others, 2005). Recently reported results from the Women's Health Initiative Memory","text_display":" others, 2005). Recently reported results from the Women's Health Initiative Memory","confidence":0.99853515625,"confidence_rate":0.9999831505134198},{"cnt":[[305,1656],[1775,1656],[1775,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1656,"width":1470,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"156bfe24372a48dbba649d6e7d35eace","type":"text","conversion_output":true,"text":"Study (WHIMS) indicate that white matter volume (detected by MRI) is associated with","text_display":" Study (WHIMS) indicate that white matter volume (detected by MRI) is associated with","confidence":1,"confidence_rate":1},{"cnt":[[305,1702],[1818,1702],[1818,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1701,"width":1513,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d92f23b3574147c795cb7b6a385f8895","type":"text","conversion_output":true,"text":"baseline BP, even after adjustment for treatment, other CVD risk factors, and age (Coker","text_display":" baseline BP, even after adjustment for treatment, other CVD risk factors, and age (Coker","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1803,1745],[1803,1794],[305,1794]],"region":{"top_left_x":305,"top_left_y":1744,"width":1498,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bbcbed6056f4e778382ad53891ee001","type":"text","conversion_output":true,"text":"L.H. and others, 2008). 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Although the beneficial effects of treating hypertension on CVD,","confidence":1,"confidence_rate":1},{"cnt":[[305,1788],[1734,1788],[1734,1837],[305,1837]],"region":{"top_left_x":305,"top_left_y":1787,"width":1429,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b96174bf089140ccad86d72f69c7f502","type":"text","conversion_output":true,"text":"such as stroke have been shown (Collins and others, 1990), it is not known whether","text_display":" such as stroke have been shown (Collins and others, 1990), it is not known whether","confidence":1,"confidence_rate":1},{"cnt":[[305,1833],[1760,1833],[1760,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1832,"width":1455,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edd26839681541c3a4a8afa9be721681","type":"text","conversion_output":true,"text":"intensive lowering of SBP as proposed in SPRINT will provide reduction in the risk for","text_display":" intensive lowering of SBP as proposed in SPRINT will provide reduction in the risk for","confidence":1,"confidence_rate":1},{"cnt":[[305,1878],[1257,1878],[1257,1927],[305,1927]],"region":{"top_left_x":305,"top_left_y":1877,"width":952,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"731e6bc2fc1446039304be1feb75d083","type":"text","conversion_output":true,"text":"developing white matter disease and brain volume loss.","text_display":" developing white matter disease and brain volume loss.","confidence":1,"confidence_rate":1},{"cnt":[[301,1955],[522,1955],[522,2013],[301,2013]],"region":{"top_left_x":300,"top_left_y":1955,"width":223,"height":59},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a33d5825fbe1422ea500f4956b79c380","type":"section_header","conversion_output":false,"children_ids":["c3026b93d708423d951bd907c83d0b8e"],"text":"","text_display":""},{"cnt":[[305,1962],[513,1962],[513,2004],[305,2004]],"region":{"top_left_x":305,"top_left_y":1961,"width":209,"height":44},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3026b93d708423d951bd907c83d0b8e","type":"text","conversion_output":true,"parent_id":"a33d5825fbe1422ea500f4956b79c380","text":"SUMMARY","text_display":"\n\n\\section*{SUMMARY}","confidence":1,"confidence_rate":1},{"cnt":[[305,2050],[1734,2050],[1734,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2049,"width":1429,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd8e96fca9da44d3afed57f6ed42b1ba","type":"text","conversion_output":true,"text":"Higher than optimal BP is the leading cause of disability adjusted life-years lost on a","text_display":"\n\nHigher than optimal BP is the leading cause of disability adjusted life-years lost on a","confidence":1,"confidence_rate":1},{"cnt":[[305,2097],[1738,2097],[1738,2144],[305,2144]],"region":{"top_left_x":305,"top_left_y":2096,"width":1434,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbab8f01b86a4ea795baae5fea9f05ec","type":"text","conversion_output":true,"text":"global basis, and more intensive control of SBP than is currently recommended may","text_display":" global basis, and more intensive control of SBP than is currently recommended may","confidence":1,"confidence_rate":1},{"cnt":[[305,2140],[1768,2140],[1768,2187],[305,2187]],"region":{"top_left_x":305,"top_left_y":2139,"width":1464,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20e69db266c443d59c541d1a46eef3bd","type":"text","conversion_output":true,"text":"contribute to reductions in stroke, heart failure, coronary heart disease, chronic kidney","text_display":" contribute to reductions in stroke, heart failure, coronary heart disease, chronic kidney","confidence":1,"confidence_rate":1},{"cnt":[[305,2183],[1772,2183],[1772,2230],[305,2230]],"region":{"top_left_x":305,"top_left_y":2182,"width":1468,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a95746bf81148b4b98896d988275b52","type":"text","conversion_output":true,"text":"disease, and dementia. This potential benefit must be weighed against potential risks,","text_display":" disease, and dementia. This potential benefit must be weighed against potential risks,","confidence":1,"confidence_rate":1},{"cnt":[[305,2228],[1687,2228],[1687,2275],[305,2275]],"region":{"top_left_x":305,"top_left_y":2227,"width":1382,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"139db308b65348cbbd1a297d68547aa9","type":"text","conversion_output":true,"text":"including complications resulting from low coronary, cerebral, and renal perfusion","text_display":" including complications resulting from low coronary, cerebral, and renal perfusion","confidence":1,"confidence_rate":1},{"cnt":[[305,2271],[1811,2271],[1811,2318],[305,2318]],"region":{"top_left_x":305,"top_left_y":2270,"width":1507,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3299dcf82a54971b366b6d395a682c7","type":"text","conversion_output":true,"text":"pressure and the medications themselves. Definitive evidence from a well designed and","text_display":" pressure and the medications themselves. Definitive evidence from a well designed and","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1631,2316],[1631,2363],[305,2363]],"region":{"top_left_x":305,"top_left_y":2316,"width":1326,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d08cd27ee3f4fb4b579513c5168a006","type":"text","conversion_output":true,"text":"conducted trial should form the foundation for pertinent recommendations and","text_display":" conducted trial should form the foundation for pertinent recommendations and","confidence":1,"confidence_rate":1},{"cnt":[[305,2359],[642,2359],[642,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":338,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c8d3f3b3ce84053b3436fbc77519cd2","type":"text","conversion_output":true,"text":"healthcare policies.","text_display":" healthcare policies.","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7e93cbae2f94f7291f04815dac3bc33","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db1c6f77ef1c460cafe3b81cff48b0ab","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2677],[1521,2677]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":44},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6266c47c78de4001996551f5371c448e","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-014","page":14,"lines":[{"cnt":[[301,245],[1167,245],[1167,316],[301,316]],"region":{"top_left_x":300,"top_left_y":244,"width":867,"height":72},"line":1,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"b762626f55154204871ac34df4005fd3","type":"section_header","conversion_output":false,"children_ids":["ab1b68d9b3d04180a8f3a06895b13108"],"text":"","text_display":""},{"cnt":[[309,251],[1162,251],[1162,312],[309,312]],"region":{"top_left_x":309,"top_left_y":251,"width":854,"height":61},"line":2,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"ab1b68d9b3d04180a8f3a06895b13108","type":"text","conversion_output":true,"parent_id":"b762626f55154204871ac34df4005fd3","text":"Chapter 2 - Overview of Trial Design","text_display":"\n\n\\section*{Chapter 2 - Overview of Trial Design}","confidence":1,"confidence_rate":1},{"cnt":[[305,348],[1721,348],[1721,397],[305,397]],"region":{"top_left_x":305,"top_left_y":348,"width":1416,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86834c30338b4575b2fe4e331cb8760e","type":"text","conversion_output":true,"text":"The SPRINT randomized controlled clinical trial will examine the effect of a high BP","text_display":"\n\nThe SPRINT randomized controlled clinical trial will examine the effect of a high BP","confidence":1,"confidence_rate":1},{"cnt":[[305,395],[1568,395],[1568,443],[305,443]],"region":{"top_left_x":305,"top_left_y":395,"width":1264,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f99f32a22f14eed978db4956dd753d0","type":"text","conversion_output":true,"text":"treatment strategy aimed at reducing SBP to a lower goal than is currently","text_display":" treatment strategy aimed at reducing SBP to a lower goal than is currently","confidence":1,"confidence_rate":1},{"cnt":[[305,438],[1740,438],[1740,486],[305,486]],"region":{"top_left_x":305,"top_left_y":438,"width":1436,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74d9e1fab302455fa680b9ae65afd205","type":"text","conversion_output":true,"text":"recommended. The primary objective is to determine whether randomization to this","text_display":" recommended. The primary objective is to determine whether randomization to this","confidence":1,"confidence_rate":1},{"cnt":[[305,481],[1807,481],[1807,531],[305,531]],"region":{"top_left_x":305,"top_left_y":481,"width":1502,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"838aeaec365944919b985c006b839c43","type":"text","conversion_output":true,"text":"intensive strategy is more effective than a standard strategy in reducing the incidence of","text_display":" intensive strategy is more effective than a standard strategy in reducing the incidence of","confidence":1,"confidence_rate":1},{"cnt":[[305,526],[1781,526],[1781,574],[305,574]],"region":{"top_left_x":305,"top_left_y":526,"width":1477,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"296e8406f4704543b145dd0492afad3b","type":"text","conversion_output":true,"text":"serious cardiovascular disease events. Other important study objectives are to assess","text_display":" serious cardiovascular disease events. Other important study objectives are to assess","confidence":1,"confidence_rate":1},{"cnt":[[305,569],[1727,569],[1727,617],[305,617]],"region":{"top_left_x":305,"top_left_y":569,"width":1423,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30b7e21392a04633bf55b7481678b5c6","type":"text","conversion_output":true,"text":"the impact of more intensive SBP reduction on renal function, incidence of probable","text_display":" the impact of more intensive SBP reduction on renal function, incidence of probable","confidence":1,"confidence_rate":1},{"cnt":[[305,614],[1807,614],[1807,662],[305,662]],"region":{"top_left_x":305,"top_left_y":614,"width":1502,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b95bdeae807245f0aef3de1267f632eb","type":"text","conversion_output":true,"text":"dementia, quality of life, cost-effectiveness, cognitive function and small vessel ischemic","text_display":" dementia, quality of life, cost-effectiveness, cognitive function and small vessel ischemic","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[305,657],[458,657],[458,703],[305,703]],"region":{"top_left_x":305,"top_left_y":657,"width":153,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33d997118dde41aebab2c1832e87ec21","type":"text","conversion_output":true,"text":"disease.","text_display":" disease.","confidence":1,"confidence_rate":1},{"cnt":[[305,748],[1813,748],[1813,797],[305,797]],"region":{"top_left_x":305,"top_left_y":747,"width":1509,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"388317fe431148649caeb75c32a087e5","type":"text","conversion_output":true,"text":"The study cohort will include approximately 9250 people aged \\(\\geq 50\\) years with SBP \\(\\geq 130\\)","text_display":"\n\nThe study cohort will include approximately 9250 people aged \\(\\geq 50\\) years with SBP \\(\\geq 130\\)","confidence":0.99755859375,"confidence_rate":0.9999739961748949},{"cnt":[[305,795],[1760,795],[1760,840],[305,840]],"region":{"top_left_x":305,"top_left_y":794,"width":1455,"height":47},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9738ff49f373431fb6ae3b1407163378","type":"text","conversion_output":true,"text":"mm Hg . SPRINT will focus on three high risk groups: patients with clinical CVD other","text_display":" mm Hg . 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Participants will be recruited over a 2 -year period at approximately 80","text_display":" (FRS) of \\(\\geq 15 \\%\\). Participants will be recruited over a 2 -year period at approximately 80","confidence":0.9985356330871582,"confidence_rate":0.9999850466409257},{"cnt":[[305,971],[1794,971],[1794,1016],[305,1016]],"region":{"top_left_x":305,"top_left_y":971,"width":1489,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"043e8603b38842ca9428bc0edd7d0191","type":"text","conversion_output":true,"text":"to 100 clinics in 5 clinical center networks (CCNs) and will be followed for up to 6 years.","text_display":" to 100 clinics in 5 clinical center networks (CCNs) and will be followed for up to 6 years.","confidence":1,"confidence_rate":1},{"cnt":[[305,1014],[1742,1014],[1742,1059],[305,1059]],"region":{"top_left_x":305,"top_left_y":1014,"width":1438,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d99f59ffa65c493e8274eca2501b24bd","type":"text","conversion_output":true,"text":"Both the number of randomizations and the length of follow-up may differ from these","text_display":" Both the number of randomizations and the length of follow-up may differ from these","confidence":1,"confidence_rate":1},{"cnt":[[305,1057],[1785,1057],[1785,1104],[305,1104]],"region":{"top_left_x":305,"top_left_y":1057,"width":1481,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e532c80289674db9ba8ec56c5b86ce88","type":"text","conversion_output":true,"text":"targets depending on how observed values of parameters differ from estimates used to","text_display":" targets depending on how observed values of parameters differ from estimates used to","confidence":1,"confidence_rate":1},{"cnt":[[305,1100],[1813,1100],[1813,1147],[305,1147]],"region":{"top_left_x":305,"top_left_y":1100,"width":1509,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07125c6e748d47abae6273357168a62a","type":"text","conversion_output":true,"text":"design the study. Approximately 4300 SPRINT participants will have CKD, and 3250 will","text_display":" design the study. Approximately 4300 SPRINT participants will have CKD, and 3250 will","confidence":0.99365234375,"confidence_rate":0.9999336700303182},{"cnt":[[305,1143],[1528,1143],[1528,1192],[305,1192]],"region":{"top_left_x":305,"top_left_y":1142,"width":1223,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdd5c890db6e40ee8ad0122fff17a0f1","type":"text","conversion_output":true,"text":"be age 75 or older. Chapter 3 presents the eligibility criteria for the trial.","text_display":" be age 75 or older. Chapter 3 presents the eligibility criteria for the trial.","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[305,1233],[1760,1233],[1760,1280],[305,1280]],"region":{"top_left_x":305,"top_left_y":1233,"width":1455,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0278b6e026b545d1b7118e0d22deba67","type":"text","conversion_output":true,"text":"Participants will be stratified by clinic and randomly assigned to either the intensive or","text_display":"\n\nParticipants will be stratified by clinic and randomly assigned to either the intensive or","confidence":1,"confidence_rate":1},{"cnt":[[305,1276],[1783,1276],[1783,1326],[305,1326]],"region":{"top_left_x":305,"top_left_y":1276,"width":1479,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"884a235dbdf84d8594bda5da25b02972","type":"text","conversion_output":true,"text":"standard SBP lowering strategy. Chapter 4 and 5 provides a general description of the","text_display":" standard SBP lowering strategy. 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Study outcomes are described","text_display":" failure, non-MI acute coronary syndrome, or CVD death. Study outcomes are described","confidence":0.9477791786193848,"confidence_rate":0.9993907113984777},{"cnt":[[305,1538],[703,1538],[703,1588],[305,1588]],"region":{"top_left_x":305,"top_left_y":1538,"width":398,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b41585b96a14e2eb9bea7b47c47ae12","type":"text","conversion_output":true,"text":"in Chapters 6, 7 and 9.","text_display":" in Chapters 6, 7 and 9.","confidence":1,"confidence_rate":1},{"cnt":[[305,1629],[1807,1629],[1807,1674],[305,1674]],"region":{"top_left_x":305,"top_left_y":1628,"width":1502,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"838198d5c5ce451fb6140605656f0246","type":"text","conversion_output":true,"text":"The sample size for SPRINT is estimated to provide \\(90 \\%\\) power to detect a \\(20 \\%\\) relative","text_display":"\n\nThe sample size for SPRINT is estimated to provide \\(90 \\%\\) power to detect a \\(20 \\%\\) relative","confidence":0.9985356330871582,"confidence_rate":0.9999847351149894},{"cnt":[[305,1671],[1807,1671],[1807,1721],[305,1721]],"region":{"top_left_x":305,"top_left_y":1671,"width":1502,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1f21f7750ab4c87ac6986856afd2e60","type":"text","conversion_output":true,"text":"decrease in the rate of the composite primary outcome in participants randomized to the","text_display":" decrease in the rate of the composite primary outcome in participants randomized to the","confidence":1,"confidence_rate":1},{"cnt":[[305,1714],[1742,1714],[1742,1764],[305,1764]],"region":{"top_left_x":305,"top_left_y":1714,"width":1438,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"682981aea0394bb687a838b893e269d1","type":"text","conversion_output":true,"text":"more intensive SBP lowering strategy. 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Sample size estimation is described further in","confidence":1,"confidence_rate":1},{"cnt":[[305,1762],[518,1762],[518,1807],[305,1807]],"region":{"top_left_x":305,"top_left_y":1761,"width":213,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f46a341fab04f8180f3367c29ea8aeb","type":"text","conversion_output":true,"text":"Chapter 10.","text_display":" Chapter 10.","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[305,1848],[1253,1848],[1253,1897],[305,1897]],"region":{"top_left_x":305,"top_left_y":1847,"width":948,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d45056157434c7781c888499713a4d7","type":"text","conversion_output":true,"text":"The major objectives of the SPRINT trial are as follows:","text_display":"\n\nThe major objectives of the SPRINT trial are as follows:","confidence":1,"confidence_rate":1},{"cnt":[[301,1929],[804,1929],[804,1987],[301,1987]],"region":{"top_left_x":300,"top_left_y":1929,"width":504,"height":59},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32a149ad832e41638204c3f873d3fb4b","type":"section_header","conversion_output":false,"children_ids":["b2d39dcc536548a1ba8f80e2ee50fafe"],"text":"","text_display":""},{"cnt":[[305,1934],[799,1934],[799,1983],[305,1983]],"region":{"top_left_x":305,"top_left_y":1933,"width":495,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2d39dcc536548a1ba8f80e2ee50fafe","type":"text","conversion_output":true,"parent_id":"32a149ad832e41638204c3f873d3fb4b","text":"2.1 Primary Hypothesis","text_display":"\n\n\\subsection*{2.1 Primary Hypothesis}","confidence":1,"confidence_rate":1},{"cnt":[[305,2024],[1749,2024],[1749,2071],[305,2071]],"region":{"top_left_x":305,"top_left_y":2023,"width":1444,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbef801105f94bd3b4ea8c15754dc78b","type":"text","conversion_output":true,"text":"In people aged \\(\\geq 50\\) years with SBP \\(\\geq 130 mm Hg\\) and either a history of CVD, eGFR","text_display":"\n\nIn people aged \\(\\geq 50\\) years with SBP \\(\\geq 130 mm Hg\\) and either a history of CVD, eGFR","confidence":0.95654296875,"confidence_rate":0.9995118821549456},{"cnt":[[305,2067],[1794,2067],[1794,2116],[305,2116]],"region":{"top_left_x":305,"top_left_y":2066,"width":1489,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a2683eb69d44a60a8d80b5fac3be5c5","type":"text","conversion_output":true,"text":"between 20 and 59, or a Framingham Risk Score (FRS) indicating 10-year CVD risk of","text_display":" between 20 and 59, or a Framingham Risk Score (FRS) indicating 10-year CVD risk of","confidence":0.9034523548325524,"confidence_rate":0.9988725038315558},{"cnt":[[305,2110],[1815,2110],[1815,2159],[305,2159]],"region":{"top_left_x":305,"top_left_y":2109,"width":1511,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c0cf5e0ca5c49b7968ca545d41228b4","type":"text","conversion_output":true,"text":"\\(\\geq 15 \\%\\), does a therapeutic strategy that targets a SBP of \\(<120 mm Hg\\) reduce the rate of","text_display":" \\(\\geq 15 \\%\\), does a therapeutic strategy that targets a SBP of \\(<120 mm Hg\\) reduce the rate of","confidence":0.9980475902557373,"confidence_rate":0.9999794284412753},{"cnt":[[305,2155],[1652,2155],[1652,2202],[305,2202]],"region":{"top_left_x":305,"top_left_y":2154,"width":1348,"height":49},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07a184e2b7304212a02b6820685248e4","type":"text","conversion_output":true,"text":"CVD events compared to a strategy that targets a SBP of \\(<140 mm Hg\\) ? 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Inclusion/exclusion criteria were made as simple as possible to ensure","text_display":" maximize safety. Inclusion/exclusion criteria were made as simple as possible to ensure","confidence":1,"confidence_rate":1},{"cnt":[[305,623],[1699,623],[1699,672],[305,672]],"region":{"top_left_x":305,"top_left_y":623,"width":1395,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fca1c0606d484c0fa1a7cda7bb78ae4e","type":"text","conversion_output":true,"text":"standard implementation across all SPRINT study sites. Specifically, the SPRINT","text_display":" standard implementation across all SPRINT study sites. 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The overall goal for recruitment is 9,250 participants, although the","text_display":" study population. The overall goal for recruitment is 9,250 participants, although the","confidence":1,"confidence_rate":1},{"cnt":[[305,1061],[1747,1061],[1747,1111],[305,1111]],"region":{"top_left_x":305,"top_left_y":1061,"width":1442,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52f587b9709b434a90dd9e7fc1076fc1","type":"text","conversion_output":true,"text":"final number of randomizations may be between 8,500 and 10,000 . For the target of","text_display":" final number of randomizations may be between 8,500 and 10,000 . 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2007).","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[1779,1216],[1779,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1474,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bb9379a77a4445ca21829b4de6eb4a4","type":"text","conversion_output":true,"text":"Finally, although renoprotective benefits have been demonstrated in CKD patients with","text_display":"\n\nFinally, although renoprotective benefits have been demonstrated in CKD patients with","confidence":1,"confidence_rate":1},{"cnt":[[305,1261],[1777,1261],[1777,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1261,"width":1472,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"181157339563482381a2261daa3afeea","type":"text","conversion_output":true,"text":"proteinuria, ACE inhibitors (and likely other RAS blockers) are less effective than other","text_display":" proteinuria, ACE inhibitors (and 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However, alpha-blockers should be used only in combination with one or more","text_display":" trials. 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Amlodipine should be considered first when a CCB is","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1742,2316],[1742,2361],[305,2361]],"region":{"top_left_x":305,"top_left_y":2316,"width":1438,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8b2cd58d6c941d68e7fd12123d33e42","type":"text","conversion_output":true,"text":"to be used. In the presence of significant proteinuria, amlodipine should probably be","text_display":" to be used. In the presence of significant proteinuria, amlodipine should probably be","confidence":1,"confidence_rate":1},{"cnt":[[305,2359],[1809,2359],[1809,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1504,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73c77324015b445cb0bc39e40833d132","type":"text","conversion_output":true,"text":"used in conjunction with a RAS blocker. If a non-dihydropyridine CCB (e.g., diltiazem) is","text_display":" used in conjunction with a RAS blocker. If a non-dihydropyridine CCB (e.g., diltiazem) is","confidence":1,"confidence_rate":1},{"cnt":[[305,2402],[1291,2402],[1291,2449],[305,2449]],"region":{"top_left_x":305,"top_left_y":2401,"width":987,"height":49},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b33807234a3e4988bfae63851eda6d72","type":"text","conversion_output":true,"text":"to be used, it should not be combined with a beta-blocker.","text_display":" to be used, it should not be combined with a beta-blocker.","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ae0ab7fd75c4eaab508a70033cd4f72","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56ce505f548642cc8b1bd13d6e4c3590","type":"page_info","conversion_output":false,"text":"24","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2675],[1521,2675]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ff8d74d1b8b43978b45eb6f774f0c22","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-027","page":27,"lines":[{"cnt":[[305,249],[1669,249],[1669,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1365,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dca60789b38748c4ae5b525790bdb38d","type":"text","conversion_output":true,"text":"The ACCORD experience (The ACCORD Study Group, 2010) has shown that a","text_display":"\n\nThe ACCORD experience (The ACCORD Study Group, 2010) has shown that a","confidence":0.9990234375,"confidence_rate":0.9999867968486782},{"cnt":[[305,294],[1772,294],[1772,342],[305,342]],"region":{"top_left_x":305,"top_left_y":294,"width":1468,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38dbe408001545e2a5abe86b54f75f1d","type":"text","conversion_output":true,"text":"treatment strategy that includes a variety of classes, can produce a 14 mm Hg delta in","text_display":" treatment strategy that includes a variety of classes, can produce a 14 mm Hg delta in","confidence":1,"confidence_rate":1},{"cnt":[[305,339],[1729,339],[1729,385],[305,385]],"region":{"top_left_x":305,"top_left_y":339,"width":1425,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3c3693ae4724dc5901b718568bdb31c","type":"text","conversion_output":true,"text":"SBP between the two randomized groups. The average number of antihypertensive","text_display":" SBP between the two randomized groups. The average number of antihypertensive","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1738,382],[1738,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1434,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f35741023c4240fb9638a0ba68abef79","type":"text","conversion_output":true,"text":"drugs used to produce this difference was 3.4 and 2.1 in the Intensive and Standard","text_display":" drugs used to produce this difference was 3.4 and 2.1 in the Intensive and Standard","confidence":1,"confidence_rate":1},{"cnt":[[305,425],[1820,425],[1820,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1515,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"005fb0a7c7c14dc688ea655f26f912cb","type":"text","conversion_output":true,"text":"Groups, respectively. It is anticipated that the study participants in the CKD subgroup of","text_display":" Groups, respectively. It is anticipated that the study participants in the CKD subgroup of","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[305,468],[1768,468],[1768,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1464,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"143bc959cf6d49b8b97b630dd5708259","type":"text","conversion_output":true,"text":"SPRINT will require a greater number of antihypertensive drugs to reach the lower BP","text_display":" SPRINT will require a greater number of antihypertensive drugs to reach the lower BP","confidence":1,"confidence_rate":1},{"cnt":[[305,511],[887,511],[887,563],[305,563]],"region":{"top_left_x":305,"top_left_y":511,"width":583,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7dae8ea718642de8d16c9c35ec232bb","type":"text","conversion_output":true,"text":"goal (Cushman and others, 2008)","text_display":" goal (Cushman and others, 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Frequency}","confidence":1,"confidence_rate":1},{"cnt":[[305,733],[1742,733],[1742,782],[305,782]],"region":{"top_left_x":305,"top_left_y":732,"width":1438,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbc72a0677614baca2bb602c15c5dbf7","type":"text","conversion_output":true,"text":"For both randomized groups, routine visit frequency will be monthly for the first three","text_display":"\n\nFor both randomized groups, routine visit frequency will be monthly for the first three","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1669,778],[1669,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1365,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4d29185889c44b6b0ebafed901abcf5","type":"text","conversion_output":true,"text":"months after randomization, then every three months for the duration of the trial.","text_display":" months after randomization, then every three months for the duration of the trial.","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1772,821],[1772,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1468,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1275da61cd34300ae17d613d2a02f68","type":"text","conversion_output":true,"text":"\"Monthly visits will continue in the Intensive Group until SBP \\(<120 mm Hg\\) (or no more","text_display":" \"Monthly visits will continue in the Intensive Group until SBP \\(<120 mm Hg\\) (or no more","confidence":0.9790723038604483,"confidence_rate":0.9997773954709365},{"cnt":[[305,868],[1781,868],[1781,917],[305,917]],"region":{"top_left_x":305,"top_left_y":867,"width":1477,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f42125430c544288b46fb584d7d665bc","type":"text","conversion_output":true,"text":"titration planned) and in the Standard group whenever SBP \\(\\geq 160 mm\\) Hg.\" Additional","text_display":" titration planned) and in the Standard group whenever SBP \\(\\geq 160 mm\\) Hg.\" Additional","confidence":0.8852648735046387,"confidence_rate":0.9986616833054138},{"cnt":[[305,915],[1783,915],[1783,965],[305,965]],"region":{"top_left_x":305,"top_left_y":915,"width":1479,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef3e79ad66a44ba29bcb4c1999b31a4c","type":"text","conversion_output":true,"text":"visits will be scheduled as needed for management of adverse effects or for monitoring","text_display":" visits will be scheduled as needed for management of adverse effects or for monitoring","confidence":1,"confidence_rate":1},{"cnt":[[305,958],[1233,958],[1233,1008],[305,1008]],"region":{"top_left_x":305,"top_left_y":958,"width":929,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f0537b96d2148d6b0e73d50806e37c3","type":"text","conversion_output":true,"text":"significant medication changes or other clinical issues.","text_display":" significant medication changes or other clinical 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4.1)}","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1678,1130],[1678,1182],[305,1182]],"region":{"top_left_x":305,"top_left_y":1130,"width":1373,"height":52},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17726e9ff5ed4084b7d5f46de23a4754","type":"text","conversion_output":true,"text":"The SBP goal for the Intensive Group, \\(<120 mm Hg\\), should be achievable in the","text_display":"\n\nThe SBP goal for the Intensive Group, \\(<120 mm Hg\\), should be achievable in the","confidence":0.9775497913360596,"confidence_rate":0.9997420099784268},{"cnt":[[305,1177],[1646,1177],[1646,1227],[305,1227]],"region":{"top_left_x":305,"top_left_y":1177,"width":1341,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bb9dfd543eb417291ae7127d4c76632","type":"text","conversion_output":true,"text":"majority of participants within 8-12 months of follow-up based on the ACCORD","text_display":" majority of participants within 8-12 months of follow-up based on the ACCORD","confidence":0.9970703125,"confidence_rate":0.9999637785889149},{"cnt":[[305,1220],[1772,1220],[1772,1270],[305,1270]],"region":{"top_left_x":305,"top_left_y":1220,"width":1468,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9dd6edbd90c4b77b0e7c28a6065cd2c","type":"text","conversion_output":true,"text":"experience (The ACCORD Study Group, 2010). For most participants in the Intensive","text_display":" experience (The ACCORD Study Group, 2010). For most participants in the Intensive","confidence":1,"confidence_rate":1},{"cnt":[[305,1263],[1740,1263],[1740,1313],[305,1313]],"region":{"top_left_x":305,"top_left_y":1263,"width":1436,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae7ce5d2abb04aeb9127f2ab7a083598","type":"text","conversion_output":true,"text":"Group, a two- or three-drug regimen of a diuretic and either an ACE inhibitor or ARB","text_display":" Group, a two- or three-drug regimen of a diuretic and either an ACE inhibitor or ARB","confidence":1,"confidence_rate":1},{"cnt":[[305,1308],[1798,1308],[1798,1356],[305,1356]],"region":{"top_left_x":305,"top_left_y":1308,"width":1494,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2050f5a62e684c6a97baa5ac47ad7455","type":"text","conversion_output":true,"text":"and/or a CCB should be initiated at randomization. If a diuretic is contraindicated or not","text_display":" and/or a CCB should be initiated at randomization. If a diuretic is contraindicated or not","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[305,1351],[1704,1351],[1704,1401],[305,1401]],"region":{"top_left_x":305,"top_left_y":1351,"width":1399,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ddeee51e2f54d1c9253ff51f74a1e99","type":"text","conversion_output":true,"text":"tolerated, an ACE inhibitor or ARB plus a CCB should be initiated. A beta-blocker","text_display":" tolerated, an ACE inhibitor or ARB plus a CCB should be initiated. A beta-blocker","confidence":1,"confidence_rate":1},{"cnt":[[305,1396],[1807,1396],[1807,1446],[305,1446]],"region":{"top_left_x":305,"top_left_y":1396,"width":1502,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0d1e5a9c20e498d9fd68eb798b5ac3d","type":"text","conversion_output":true,"text":"should be included in the initial regimen, usually in combination with a diuretic, if there is","text_display":" should be included in the initial regimen, usually in combination with a diuretic, if there is","confidence":1,"confidence_rate":1},{"cnt":[[305,1439],[1714,1439],[1714,1489],[305,1489]],"region":{"top_left_x":305,"top_left_y":1439,"width":1410,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b554f98a68e459c9e2ab9c04f467563","type":"text","conversion_output":true,"text":"a compelling indication for a beta-blocker. Drug doses should be increased and/or","text_display":" a compelling indication for a beta-blocker. Drug doses should be increased and/or","confidence":1,"confidence_rate":1},{"cnt":[[305,1487],[1760,1487],[1760,1532],[305,1532]],"region":{"top_left_x":305,"top_left_y":1486,"width":1455,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7deb9126f914989bb3b5380e351c688","type":"text","conversion_output":true,"text":"additional antihypertensive medications should be added at each visit in the Intensive","text_display":" additional antihypertensive medications should be added at each visit in the Intensive","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1798,1525],[1798,1577],[305,1577]],"region":{"top_left_x":305,"top_left_y":1525,"width":1494,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cff1d4c6813f4a8daae6e4262c4f5210","type":"text","conversion_output":true,"text":"Group, usually at monthly intervals, until the participant's goal of \\(<120 mm Hg\\) has been","text_display":" Group, usually at monthly intervals, until the participant's goal of \\(<120 mm Hg\\) has been","confidence":0.9771823883056641,"confidence_rate":0.9997644975067932},{"cnt":[[305,1573],[1727,1573],[1727,1622],[305,1622]],"region":{"top_left_x":305,"top_left_y":1572,"width":1423,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9553872904d462e9103913da74a2a70","type":"text","conversion_output":true,"text":"reached or the investigator decides no further antihypertensive medications may be","text_display":" reached or the investigator decides no further antihypertensive medications may be","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[305,1616],[434,1616],[434,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1615,"width":129,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7b4c9d3a60545c984fd2743d5027ec3","type":"text","conversion_output":true,"text":"added.","text_display":" added.","confidence":1,"confidence_rate":1},{"cnt":[[305,1702],[1717,1702],[1717,1755],[305,1755]],"region":{"top_left_x":305,"top_left_y":1701,"width":1412,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4475bd1a8bf54b7bb962f95e342bfb5a","type":"text","conversion_output":true,"text":"SPRINT provides a unique opportunity to determine both the efficacy and safety of","text_display":"\n\nSPRINT provides a unique opportunity to determine both the efficacy and safety of","confidence":1,"confidence_rate":1},{"cnt":[[305,1749],[1772,1749],[1772,1798],[305,1798]],"region":{"top_left_x":305,"top_left_y":1748,"width":1468,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"446922ad8b80439ca267b15c2caf0796","type":"text","conversion_output":true,"text":"intensive BP control in elderly populations. However, based on limited data, there is a","text_display":" intensive BP control in elderly populations. However, based on limited data, there is a","confidence":1,"confidence_rate":1},{"cnt":[[305,1792],[1798,1792],[1798,1841],[305,1841]],"region":{"top_left_x":305,"top_left_y":1791,"width":1494,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c856566052e4998a6a8c1a018f9a636","type":"text","conversion_output":true,"text":"concern that this population may be less tolerant of aggressive BP lowering. Therefore,","text_display":" concern that this population may be less tolerant of aggressive BP lowering. 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If the participant is asymptomatic at the first post-","text_display":" return visit scheduled in one month. If the participant is asymptomatic at the first post","confidence":1,"confidence_rate":1},{"cnt":[[305,2011],[1755,2011],[1755,2060],[305,2060]],"region":{"top_left_x":305,"top_left_y":2010,"width":1451,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a1491e550994ec6b56cd7e2a750bea6","type":"text","conversion_output":true,"text":"randomization visit and SBP \\(\\geq 130 mm Hg\\), a second agent will be added and titration","text_display":"randomization visit and SBP \\(\\geq 130 mm Hg\\), a second agent will be added and titration","confidence":0.951171875,"confidence_rate":0.999461859882083},{"cnt":[[305,2054],[864,2054],[864,2101],[305,2101]],"region":{"top_left_x":305,"top_left_y":2053,"width":559,"height":49},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c599da554634dc2bcb9c1e65d396b7d","type":"text","conversion_output":true,"text":"continued as indicated in above.","text_display":" continued as indicated in above.","confidence":1,"confidence_rate":1},{"cnt":[[301,2138],[591,2138],[591,2196],[301,2196]],"region":{"top_left_x":300,"top_left_y":2137,"width":291,"height":59},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"567a1dfb38a04e309a0618cfa996aa89","type":"section_header","conversion_output":false,"children_ids":["ab13de69d1274aa698972d57dca68922"],"text":"","text_display":""},{"cnt":[[305,2144],[587,2144],[587,2191],[305,2191]],"region":{"top_left_x":305,"top_left_y":2144,"width":282,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab13de69d1274aa698972d57dca68922","type":"text","conversion_output":true,"parent_id":"567a1dfb38a04e309a0618cfa996aa89","text":"Milepost Visits","text_display":"\n\n\\section*{Milepost Visits}","confidence":1,"confidence_rate":1},{"cnt":[[305,2230],[1768,2230],[1768,2279],[305,2279]],"region":{"top_left_x":305,"top_left_y":2230,"width":1464,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"965f7269a86a4f2b8896ba2072bc2088","type":"text","conversion_output":true,"text":"\"Clinical inertia\" in hypertension management, where clinicians fail to intensify therapy","text_display":"\n\"Clinical inertia\" in hypertension management, where clinicians fail to intensify therapy","confidence":0.9697265625,"confidence_rate":0.99967302004881},{"cnt":[[305,2275],[1687,2275],[1687,2322],[305,2322]],"region":{"top_left_x":305,"top_left_y":2275,"width":1382,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbccc4faa1be497398bb89ecd8ba28dd","type":"text","conversion_output":true,"text":"despite patients not being at goal BP, has been observed in both clinical practice","text_display":" despite patients not being at goal BP, has been observed in both clinical practice","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1798,2316],[1798,2368],[305,2368]],"region":{"top_left_x":305,"top_left_y":2316,"width":1494,"height":52},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"613fe4f2a1c848edb5335852eddfa7f5","type":"text","conversion_output":true,"text":"(Berlowitz and others, 1998) and clinical trial settings (Cushman and others, 2002). For","text_display":" (Berlowitz and others, 1998) and clinical trial settings (Cushman and others, 2002). For","confidence":1,"confidence_rate":1},{"cnt":[[305,2363],[1813,2363],[1813,2413],[305,2413]],"region":{"top_left_x":305,"top_left_y":2363,"width":1509,"height":50},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e793c1c022f49d1bd814fd1a6736228","type":"text","conversion_output":true,"text":"this reason, \"Milepost Visits\" were used in the intensive BP group in the ACCORD trial to","text_display":" this reason, \"Milepost Visits\" were used in the intensive BP group in the ACCORD trial to","confidence":1,"confidence_rate":1},{"cnt":[[305,2406],[1772,2406],[1772,2456],[305,2456]],"region":{"top_left_x":305,"top_left_y":2406,"width":1468,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd3495909f1940338473fee5d4f00272","type":"text","conversion_output":true,"text":"assist in reaching goal SBP (Cushman and others, 2007). For SPRINT participants in","text_display":" assist in reaching goal SBP (Cushman and others, 2007). For SPRINT participants in","confidence":1,"confidence_rate":1},{"cnt":[[305,2451],[1674,2451],[1674,2501],[305,2501]],"region":{"top_left_x":305,"top_left_y":2451,"width":1369,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef002adea0814a598ebb9eb1584c6f5a","type":"text","conversion_output":true,"text":"the Intensive Group, Milepost Visits will be every 6 months throughout follow-up,","text_display":" the Intensive Group, Milepost Visits will be every 6 months throughout follow-up,","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a129c52e3504d09a64d3075bd9252d8","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1040,2638],[1089,2638],[1089,2677],[1040,2677]],"region":{"top_left_x":1039,"top_left_y":2638,"width":51,"height":39},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"909179994b7949758601302871853ecc","type":"page_info","conversion_output":false,"text":"25","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1820,2634],[1820,2679],[1521,2679]],"region":{"top_left_x":1521,"top_left_y":2633,"width":299,"height":47},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3da91e2bb7524d67b0703794798c1908","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-028","page":28,"lines":[{"cnt":[[305,249],[1811,249],[1811,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1507,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55d8c2155a074585aa9e9f3dc4684f49","type":"text","conversion_output":true,"text":"beginning at the 6-month visit. If the SBP is not \\(<120 mm Hg\\) at a Milepost Visit, then an","text_display":"\nbeginning at the 6-month visit. If the SBP is not \\(<120 mm Hg\\) at a Milepost Visit, then an","confidence":0.6564846038818359,"confidence_rate":0.9957579519281718},{"cnt":[[305,296],[1777,296],[1777,342],[305,342]],"region":{"top_left_x":305,"top_left_y":296,"width":1472,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0e5130be2f842b0b798a37a74025e7b","type":"text","conversion_output":true,"text":"antihypertensive drug from a class different from what is being taken should be added,","text_display":" antihypertensive drug from a class different from what is being taken should be added,","confidence":1,"confidence_rate":1},{"cnt":[[305,339],[1695,339],[1695,385],[305,385]],"region":{"top_left_x":305,"top_left_y":339,"width":1391,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ad7ece07dbd4addb930778578b3b251","type":"text","conversion_output":true,"text":"unless there are compelling reasons to wait. A \"Milepost Exemption Form\" will be","text_display":" unless there are compelling reasons to wait. A \"Milepost Exemption Form\" will be","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1611,382],[1611,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1307,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94557c1d2c8748f3ad3ee20b3692c164","type":"text","conversion_output":true,"text":"completed whenever a new drug is not added at a Milepost Visit in which the","text_display":" completed whenever a new drug is not added at a Milepost Visit in which the","confidence":1,"confidence_rate":1},{"cnt":[[305,425],[1807,425],[1807,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1502,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3426665ad66431d94f122eb63c44ba3","type":"text","conversion_output":true,"text":"participant's BP is not \\(<120 mm Hg\\) to document the reason for not adding a drug and to","text_display":" participant's BP is not \\(<120 mm Hg\\) to document the reason for not adding a drug and to","confidence":0.46431703492999077,"confidence_rate":0.9920403089595108},{"cnt":[[305,471],[1661,471],[1661,518],[305,518]],"region":{"top_left_x":305,"top_left_y":470,"width":1356,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9a6106eb8574d65a35bbb79eb196d01","type":"text","conversion_output":true,"text":"outline a plan for making progress toward goal in that participant. Milepost Visit","text_display":" outline a plan for making progress toward goal in that participant. Milepost Visit","confidence":1,"confidence_rate":1},{"cnt":[[305,516],[1772,516],[1772,561],[305,561]],"region":{"top_left_x":305,"top_left_y":515,"width":1468,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d6042fb50324534b9b2284fac242c0c","type":"text","conversion_output":true,"text":"procedures do not apply to the Standard Group. Once the Intensive Group participant","text_display":" procedures do not apply to the Standard Group. Once the Intensive Group participant","confidence":1,"confidence_rate":1},{"cnt":[[305,559],[1807,559],[1807,606],[305,606]],"region":{"top_left_x":305,"top_left_y":558,"width":1502,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c606a478be68403bb631ba6e364d9f00","type":"text","conversion_output":true,"text":"has been prescribed 5 drugs at maximally tolerated doses, if the BP remains above goal","text_display":" has been prescribed 5 drugs at maximally tolerated doses, if the BP remains above goal","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1772,602],[1772,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1468,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc2f47aa18c74acc832ab063a09ac6b3","type":"text","conversion_output":true,"text":"at subsequent Milepost Visits, it will be permitted to substitute a different class into the","text_display":" at subsequent Milepost Visits, it will be permitted to substitute a different class into the","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1725,645],[1725,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1421,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2a11c169814490d970a4cdfcc3246f4","type":"text","conversion_output":true,"text":"regimen instead of adding another drug or increasing the dose of a drug. However,","text_display":" regimen instead of adding another drug or increasing the dose of a drug. However,","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[1815,692],[1815,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1511,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f6b3426e10843d6a4f61bfa13ec8ec9","type":"text","conversion_output":true,"text":"additional (more than 5) drugs may be needed to achieve goal SBP in some participants.","text_display":" additional (more than 5) drugs may be needed to achieve goal SBP in some participants.","confidence":0.68603515625,"confidence_rate":0.995867612410346},{"cnt":[[305,735],[1755,735],[1755,780],[305,780]],"region":{"top_left_x":305,"top_left_y":734,"width":1451,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c678b1c94000402a80fd07f94525d140","type":"text","conversion_output":true,"text":"Medication adherence will be assessed routinely in SPRINT and should be evaluated","text_display":" Medication adherence will be assessed routinely in SPRINT and should be evaluated","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1777,778],[1777,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1472,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4ae672e4a324030ac522099040e083f","type":"text","conversion_output":true,"text":"especially carefully for participants not at goal on 4 or more medications. Strategies to","text_display":" especially carefully for participants not at goal on 4 or more medications. Strategies to","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1745,821],[1745,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1440,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"929262383ad54bd296b17cdb63ba928c","type":"text","conversion_output":true,"text":"enhance adherence are described in brief in Chapter 5 and in detail in the Manual of","text_display":" enhance adherence are described in brief in Chapter 5 and in detail in the Manual of","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[305,866],[913,866],[913,909],[305,909]],"region":{"top_left_x":305,"top_left_y":865,"width":609,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5c20397dc204c84a730fdc4ec23bb6c","type":"text","conversion_output":true,"text":"Procedures and Adherence Binder.","text_display":" Procedures and Adherence Binder.","confidence":1,"confidence_rate":1},{"cnt":[[301,947],[988,947],[988,1008],[301,1008]],"region":{"top_left_x":300,"top_left_y":947,"width":689,"height":61},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ea3db2975bd4bb5a2607a623591bdcd","type":"section_header","conversion_output":false,"children_ids":["4c6a84fb983740338571302a5c208123"],"text":"","text_display":""},{"cnt":[[305,952],[984,952],[984,1003],[305,1003]],"region":{"top_left_x":305,"top_left_y":951,"width":679,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c6a84fb983740338571302a5c208123","type":"text","conversion_output":true,"parent_id":"9ea3db2975bd4bb5a2607a623591bdcd","text":"Standard BP Goal Group (Figure 4.2)","text_display":"\n\n\\section*{Standard BP Goal Group (Figure 4.2)}","confidence":0.9990234375,"confidence_rate":0.9999755743071164},{"cnt":[[305,1040],[1680,1040],[1680,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1376,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3ba3db55b96486f94a261e8a2e65603","type":"text","conversion_output":true,"text":"The SBP goal for the Standard Group, \\(<140 mm Hg\\), should be achievable in the","text_display":"\n\nThe SBP goal for the Standard Group, \\(<140 mm Hg\\), should be achievable in the","confidence":0.9394824504852295,"confidence_rate":0.9992827155332424},{"cnt":[[305,1087],[1714,1087],[1714,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":1410,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9a002ec5efd43469dcbdd4329f81e4e","type":"text","conversion_output":true,"text":"majority of participants within 3-6 months, based on the ACCORD experience (The","text_display":" majority of participants within 3-6 months, based on the ACCORD experience (The","confidence":0.9482421875,"confidence_rate":0.999367517514424},{"cnt":[[305,1130],[1800,1130],[1800,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1496,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc9741886aaf4adcbe7283d8d27f8266","type":"text","conversion_output":true,"text":"ACCORD Study Group, 2010). The standard BP protocol is designed to achieve a SBP","text_display":" ACCORD Study Group, 2010). The standard BP protocol is designed to achieve a SBP","confidence":0.99658203125,"confidence_rate":0.9999597205365387},{"cnt":[[305,1173],[1815,1173],[1815,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1511,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24fe254fd07a48d8bba6880aea33468c","type":"text","conversion_output":true,"text":"of \\(135-139 mm Hg\\) in as many participants as possible. Participants in this group may or","text_display":" of \\(135-139 mm Hg\\) in as many participants as possible. Participants in this group may or","confidence":0.9607672691345215,"confidence_rate":0.9995874760901627},{"cnt":[[305,1216],[1588,1216],[1588,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1283,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3e98026281f48b499578d86919ffcec","type":"text","conversion_output":true,"text":"may not be on treatment with one or more antihypertensive medications. If","text_display":" may not be on treatment with one or more antihypertensive medications. 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These will include the topics of medical nutrition therapy, weight","text_display":" study-wide use. 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Unlike most educational materials for BP, the SPRINT materials will not include","text_display":" trial. 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A physical examination is included for safety but is","text_display":" (subset) and quality of life measurements. 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The preferred method is the","text_display":" using an automated device or manual devises if necessary. 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& Screening /RZ & 1 mo & 2 mo & 3 mo & 6 mo & 9 mo & \\(1 ~ y r\\) & Q 3 mo & Q 6 mo & 2 yr & 3 yr & \\(4 ~ y r\\) & 5 yr or Close out \\\\\n\\hline Fasting blood collection & & & & & & & & & & & & & \\\\\n\\hline Chemistry profile & X & X & & X & X & & X & & X & X & X & X & X \\\\\n\\hline Fasting glucose & X & & & & & & & & & X & & X & \\\\\n\\hline Lipid profile & X & & & & & & X & & & X & & & \\\\\n\\hline Serum and plasma storage & X & & & & & & X & & & X & & X & \\\\\n\\hline Genomic material & X & & & & & & & & & & & & \\\\\n\\hline Urine collection & & & & & & & & & & & & & \\\\\n\\hline Albumin, creatinine & X & & & & X & & X & & & X & X & X & X \\\\\n\\hline Urine storage & X & & & & & & X & & & X & & X & \\\\\n\\hline Physical measures & & & & & & & & & & & & & \\\\\n\\hline Seated blood pressure, pulse, \\& medication adjustment & X & X & X & X & X & X & X & X & & X & X & X & X \\\\\n\\hline Standing blood pressure & X & X & & & X & & X & & & X & X & X & X \\\\\n\\hline Weight & X & & & & & & X & & & X & X & X & X \\\\\n\\hline Height & X & & & & & & & & & & & & \\\\\n\\hline ECG & X & & & & & & & & & X & & X & X \\\\\n\\hline Physical examination & X & & & & & & X & & & X & X & X & X \\\\\n\\hline 4 meter walk ( \\(\\geq 75\\) ONLY) & X & & & & & & X & & & X & X & X & X \\\\\n\\hline Questionnaires & & & & & & & & & & & & & \\\\\n\\hline Medical history & X & & & & & & & & & & & & \\\\\n\\hline Sociodemographics & X & & & & & & & & & & & & \\\\\n\\hline Smoking/alcohol use & X & & & & & & X & & & X & X & X & X \\\\\n\\hline Concomitant medications & X & & & & & & X & & & X & X & X & X \\\\\n\\hline Adherence \\& Adverse Events & & X & X & X & X & X & X & X & & X & X & X & X \\\\\n\\hline Outcomes Ascertainment & & & & X & X & X & X & X & & X & X & X & X \\\\\n\\hline Health related quality of life & & & & & & & & & & & & & \\\\\n\\hline EQ-5D & X & & & & & & X & & & X & X & X & X \\\\\n\\hline Veterans Rand 12 & X & & & & & & X & & & X & X & X & X \\\\\n\\hline PHQ-9 Depression & X & & & & & & X & & & X & X & X & X \\\\\n\\hline Patient satisfaction & X & & & & & & X & & & & & X & \\\\\n\\hline Health related quality of life (subsets) & & & & & & & & & & & & & \\\\\n\\hline Falls Efficacy (FESI-I) & X & & & & X & & X & & & X & X & X & X \\\\\n\\hline Sexual Function (FSFI/IEFF) & X & & & & X & & X & & & X & X & X & X \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5.1. Measures and Frequency}\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|l|l|l|}\n\\hline & Screening /RZ & 1 mo & 2 mo & 3 mo & 6 mo & 9 mo & \\(1 ~ y r\\) & Q 3 mo & Q 6 mo & 2 yr & 3 yr & \\(4 ~ y r\\) & 5 yr or Close out \\\\\n\\hline Fasting blood collection & & & & & & & & & & & & & \\\\\n\\hline Chemistry profile & X & X & & X & X & & X & & X & X & X & X & X \\\\\n\\hline Fasting glucose & X & & & & & & & & & X & & X & \\\\\n\\hline Lipid profile & X & & & & & & X & & & X & & & \\\\\n\\hline Serum and plasma storage & X & & & & & & X & & & X & & X & \\\\\n\\hline Genomic material & X & & & & & & & & & & & & \\\\\n\\hline Urine collection & & & & & & & & & & & & & \\\\\n\\hline Albumin, creatinine & X & & & & X & & X & & & X & X & X & X \\\\\n\\hline Urine storage & X & & & & & & X & & & X & & X & \\\\\n\\hline Physical measures & & & & & & & & & & & & & \\\\\n\\hline Seated blood pressure, pulse, \\& medication adjustment & X & X & X & X & X & X & X & X & & X & X & X & X \\\\\n\\hline 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and detailed neurocognitive test battery (the","confidence":1,"confidence_rate":1},{"cnt":[[305,954],[1811,954],[1811,1001],[305,1001]],"region":{"top_left_x":305,"top_left_y":953,"width":1507,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddf9dcc2ef4e4a7da386e1c4447574cc","type":"text","conversion_output":true,"text":"Extended Cognitive Assessment Battery) plus the Functional Assessment Questionnaire","text_display":" Extended Cognitive Assessment Battery) plus the Functional Assessment Questionnaire","confidence":1,"confidence_rate":1},{"cnt":[[305,999],[1742,999],[1742,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":999,"width":1438,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2cb71499b8f4a07951ade02a948758a","type":"text","conversion_output":true,"text":"which assesses impairments in daily living skills as a result of cognitive impairments.","text_display":" which assesses impairments in daily living skills as a result of cognitive impairments.","confidence":1,"confidence_rate":1},{"cnt":[[305,1040],[1656,1040],[1656,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1352,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a90fa3dbe1d044328f46dd48629be36a","type":"text","conversion_output":true,"text":"Last, all the above available tests and questionnaire data will be submitted to a","text_display":" Last, all the above available tests and questionnaire data will be submitted to a","confidence":1,"confidence_rate":1},{"cnt":[[305,1085],[1790,1085],[1790,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1084,"width":1485,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcb911e5d5fa4361ae28a1befb058b52","type":"text","conversion_output":true,"text":"centralized, web-based system for adjudication by a panel of dementia experts who will","text_display":" centralized, web-based system for adjudication by a panel of dementia experts who will","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1772,1130],[1772,1177],[305,1177]],"region":{"top_left_x":305,"top_left_y":1130,"width":1468,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a230fc41e88f4b4cad409928a5baf51f","type":"text","conversion_output":true,"text":"assign final study classifications of probable dementia (PD), mild cognitive impairment","text_display":" assign final study classifications of probable dementia (PD), mild cognitive impairment","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[305,1173],[793,1173],[793,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":488,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0e856fb20794ee2a6f17908f138e6b6","type":"text","conversion_output":true,"text":"(MCI) or no 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We estimate \\(20-25 \\%\\) of","text_display":" the trial by using available baseline cognition data from SPRINT. 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At the years 2 and 4 follow-up, participants","text_display":" item Functional Assessment Questionnaire). At the years 2 and 4 follow-up, participants","confidence":1,"confidence_rate":1},{"cnt":[[305,516],[1631,516],[1631,561],[305,561]],"region":{"top_left_x":305,"top_left_y":515,"width":1326,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef2e87e6d757442ba3b47b025fb34a72","type":"text","conversion_output":true,"text":"who trip the screening battery will also be administered the SPRINT Extended","text_display":" who trip the screening battery will also be administered the SPRINT Extended","confidence":1,"confidence_rate":1},{"cnt":[[305,559],[1796,559],[1796,604],[305,604]],"region":{"top_left_x":305,"top_left_y":558,"width":1492,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec80bf50e1c547f29d034d2dbdb6096b","type":"text","conversion_output":true,"text":"Cognitive Assessment Battery for adjudication of incident dementia. In order to achieve","text_display":" Cognitive Assessment Battery for adjudication of incident dementia. In order to achieve","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1661,602],[1661,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1356,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab6a1d1dc2fa465282aa8eab08f406d2","type":"text","conversion_output":true,"text":"the \\(20-25 \\%\\) target, various cut-points for the Cognition Screening Battery will be","text_display":" the \\(20-25 \\%\\) target, various cut-points for the Cognition Screening Battery will be","confidence":0.99560546875,"confidence_rate":0.9999505156560203},{"cnt":[[305,647],[1727,647],[1727,694],[305,694]],"region":{"top_left_x":305,"top_left_y":646,"width":1423,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f0810c2ba1f4d198c91bd1e2dd200ee","type":"text","conversion_output":true,"text":"compared and adjustments will be made to maximize study efficiency and economy","text_display":" compared and adjustments will be made to maximize study efficiency and economy","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[569,692],[569,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":265,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4daf3be66214cbab1064b73143a26af","type":"text","conversion_output":true,"text":"during the trial.","text_display":" during the trial.","confidence":1,"confidence_rate":1},{"cnt":[[301,855],[1304,855],[1304,913],[301,913]],"region":{"top_left_x":300,"top_left_y":855,"width":1005,"height":59},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c18dadfde0b493c911a9334069958a2","type":"section_header","conversion_output":false,"children_ids":["3c2088d06bf04a3aa45bb81f9e1783f6"],"text":"","text_display":""},{"cnt":[[305,859],[1298,859],[1298,909],[305,909]],"region":{"top_left_x":305,"top_left_y":859,"width":993,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c2088d06bf04a3aa45bb81f9e1783f6","type":"text","conversion_output":true,"parent_id":"5c18dadfde0b493c911a9334069958a2","text":"6.4.3 SPRINT Extended Cognitive Assessment Battery","text_display":"\n\n\\subsection*{6.4.3 SPRINT Extended Cognitive Assessment Battery}","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[305,947],[1747,947],[1747,995],[305,995]],"region":{"top_left_x":305,"top_left_y":947,"width":1442,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05723e5195a045459a708744ff1bae59","type":"text","conversion_output":true,"text":"The Extended Cognitive Assessment Battery will provide a more comprehensive and","text_display":"\n\nThe Extended Cognitive Assessment Battery will provide a more comprehensive and","confidence":1,"confidence_rate":1},{"cnt":[[305,993],[1626,993],[1626,1038],[305,1038]],"region":{"top_left_x":305,"top_left_y":992,"width":1322,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f602ab5eed44f1b83972a91117a9a7f","type":"text","conversion_output":true,"text":"detailed assessment of specific major cognitive functions (memory, language,","text_display":" detailed assessment of specific major cognitive functions (memory, language,","confidence":0.9990234375,"confidence_rate":0.9999879378548738},{"cnt":[[305,1036],[1766,1036],[1766,1081],[305,1081]],"region":{"top_left_x":305,"top_left_y":1035,"width":1462,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"072e9d32af014e9693e63c8fac1f6935","type":"text","conversion_output":true,"text":"visuospatial skills, executive function) that are necessary for classification of dementia","text_display":" visuospatial skills, executive function) that are necessary for classification of dementia","confidence":1,"confidence_rate":1},{"cnt":[[305,1079],[1790,1079],[1790,1126],[305,1126]],"region":{"top_left_x":305,"top_left_y":1078,"width":1485,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdf631906fec44eea20ce8a2a589705c","type":"text","conversion_output":true,"text":"and for detecting domain-specific changes. During follow-up years 2 and 4, participants","text_display":" and for detecting domain-specific changes. During follow-up years 2 and 4, participants","confidence":0.70263671875,"confidence_rate":0.9962919940192032},{"cnt":[[305,1124],[1760,1124],[1760,1171],[305,1171]],"region":{"top_left_x":305,"top_left_y":1123,"width":1455,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c09bd16321894e26b65694a61ec1c508","type":"text","conversion_output":true,"text":"scoring in the impaired range on the Cognition Screening Battery will be administered","text_display":" scoring in the impaired range on the Cognition Screening Battery will be administered","confidence":1,"confidence_rate":1},{"cnt":[[305,1164],[1725,1164],[1725,1214],[305,1214]],"region":{"top_left_x":305,"top_left_y":1164,"width":1421,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc0325eab5fe46998eeada0573da133d","type":"text","conversion_output":true,"text":"the Extended Cognitive Assessment Battery at their next scheduled visit (typically a","text_display":" the Extended Cognitive Assessment Battery at their next scheduled visit (typically a","confidence":1,"confidence_rate":1},{"cnt":[[305,1212],[1678,1212],[1678,1257],[305,1257]],"region":{"top_left_x":305,"top_left_y":1211,"width":1373,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0034dda113a94943bb8c2f34545c0356","type":"text","conversion_output":true,"text":"blood pressure assessment and medication distribution visit). This entire battery","text_display":" blood pressure assessment and medication distribution visit). This entire battery","confidence":1,"confidence_rate":1},{"cnt":[[305,1255],[1800,1255],[1800,1300],[305,1300]],"region":{"top_left_x":305,"top_left_y":1254,"width":1496,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ac5bf8ecb784eb6ac0b9435185d468d","type":"text","conversion_output":true,"text":"requires less than 40 minutes including scoring and data entry and less than 30 minutes","text_display":" requires less than 40 minutes including scoring and data entry and less than 30 minutes","confidence":1,"confidence_rate":1},{"cnt":[[305,1298],[1162,1298],[1162,1345],[305,1345]],"region":{"top_left_x":305,"top_left_y":1297,"width":858,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eecad2cbb6dd4cd58da4d22cd59848eb","type":"text","conversion_output":true,"text":"in persons without significant memory impairment.","text_display":" in persons without significant memory impairment.","confidence":1,"confidence_rate":1},{"cnt":[[305,1386],[1760,1386],[1760,1433],[305,1433]],"region":{"top_left_x":305,"top_left_y":1385,"width":1455,"height":49},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9693a50650bf4e41ba35f62399a2b3ac","type":"text","conversion_output":true,"text":"The neurocognitive tests comprising the Extended Cognitive Assessment Battery are:","text_display":"\n\nThe neurocognitive tests comprising the Extended Cognitive Assessment Battery are:","confidence":1,"confidence_rate":1},{"cnt":[[374,1473],[1695,1470],[1695,1519],[374,1522]],"region":{"top_left_x":373,"top_left_y":1470,"width":1323,"height":52},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e61afd60eea4806849170d5338e23c0","type":"text","conversion_output":true,"text":"1) The Hopkins Verbal Learning Test (HVLT) (Brandt and Benedict, 2001): A","text_display":"\n1) The Hopkins Verbal Learning Test (HVLT) (Brandt and 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learning and memory task with immediate recall, delayed recall and recognition","confidence":1,"confidence_rate":1},{"cnt":[[430,1607],[660,1607],[660,1652],[430,1652]],"region":{"top_left_x":429,"top_left_y":1607,"width":231,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"716da30ebad84fa79e08a995fb442f6d","type":"text","conversion_output":true,"text":"components.","text_display":" components.","confidence":1,"confidence_rate":1},{"cnt":[[370,1693],[1807,1693],[1807,1740],[370,1740]],"region":{"top_left_x":369,"top_left_y":1692,"width":1438,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d6c007851524a459ed73773e7415f04","type":"text","conversion_output":true,"text":"2) The Trail Making Test: Parts A and B (Reitan R.M., 1958): The Trail Making Test","text_display":"\n2) The Trail Making Test: Parts A and B (Reitan R.M., 1958): The Trail Making Test","confidence":1,"confidence_rate":1},{"cnt":[[432,1738],[1777,1738],[1777,1783],[432,1783]],"region":{"top_left_x":431,"top_left_y":1738,"width":1346,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bafcb395feb420e9f00cdeefdde3eb6","type":"text","conversion_output":true,"text":"(TMT) is a two-part test measuring speed of processing and executive function.","text_display":" (TMT) is a two-part test measuring speed of processing and executive function.","confidence":1,"confidence_rate":1},{"cnt":[[432,1781],[1760,1781],[1760,1828],[432,1828]],"region":{"top_left_x":431,"top_left_y":1781,"width":1329,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22ae3f2ba0644dcaa9d91c5edbeeed49","type":"text","conversion_output":true,"text":"The times to complete Part A and Part B are the primary measures of interest.","text_display":" The times to complete Part A and Part B are the primary measures of 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Data used in the adjudication will","text_display":" blinded to study assignment and blood pressure data. Data used in the adjudication will","confidence":1,"confidence_rate":1},{"cnt":[[305,593],[1777,593],[1777,642],[305,642]],"region":{"top_left_x":305,"top_left_y":592,"width":1472,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c07c4efa8e84fc0a13637b6555593d7","type":"text","conversion_output":true,"text":"include all available cognitive test data (SPRINT Cognition Screening Battery, SPRINT","text_display":" include all available cognitive test data (SPRINT Cognition Screening Battery, SPRINT","confidence":1,"confidence_rate":1},{"cnt":[[305,638],[1798,638],[1798,685],[305,685]],"region":{"top_left_x":305,"top_left_y":638,"width":1494,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5a197825224476387d014a156de5fd6","type":"text","conversion_output":true,"text":"Extended Cognitive Battery), functional status assessments (FAQ or DQ) and additional","text_display":" Extended Cognitive Battery), functional status assessments (FAQ or DQ) and additional","confidence":1,"confidence_rate":1},{"cnt":[[305,683],[1687,683],[1687,728],[305,728]],"region":{"top_left_x":305,"top_left_y":683,"width":1382,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"502f9562474e41ae8fdba8f805e70d7f","type":"text","conversion_output":true,"text":"data including demographic information and medical historyEach suspected case","text_display":" data including demographic information and medical historyEach suspected case","confidence":1,"confidence_rate":1},{"cnt":[[305,726],[1783,726],[1783,776],[305,776]],"region":{"top_left_x":305,"top_left_y":726,"width":1479,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9300675fa3a5477ab7ac7c090fac8145","type":"text","conversion_output":true,"text":"identified by our scoring criteria (see 6.4) will be randomly assigned to two members of","text_display":" identified by our scoring criteria (see 6.4) will be randomly assigned to two members of","confidence":0.994631290435791,"confidence_rate":0.9999421180959227},{"cnt":[[305,769],[1738,769],[1738,819],[305,819]],"region":{"top_left_x":305,"top_left_y":769,"width":1434,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a9134388bc6471e8119acdf36757cf4","type":"text","conversion_output":true,"text":"the Adjudication Committee for review. Adjudicators will independently review all the","text_display":" the Adjudication Committee for review. Adjudicators will independently review all the","confidence":1,"confidence_rate":1},{"cnt":[[305,814],[1760,814],[1760,862],[305,862]],"region":{"top_left_x":305,"top_left_y":814,"width":1455,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebd0697136884949a2ba502ff94fe241","type":"text","conversion_output":true,"text":"available data via a web-based system before recording their classification-Dementia,","text_display":" available data via a web-based system before recording their classification-Dementia,","confidence":1,"confidence_rate":1},{"cnt":[[305,859],[1803,859],[1803,904],[305,904]],"region":{"top_left_x":305,"top_left_y":859,"width":1498,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7348aeba8a7046ab835215f20c9e3488","type":"text","conversion_output":true,"text":"MCI or No Impairment. Each adjudicator will be masked to the other's classification and","text_display":" MCI or No Impairment. Each adjudicator will be masked to the other's classification and","confidence":0.7928295588704941,"confidence_rate":0.9975333980050264},{"cnt":[[305,902],[1768,902],[1768,947],[305,947]],"region":{"top_left_x":305,"top_left_y":902,"width":1464,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3ac6da8dec449e8bda2e62b129b7b99","type":"text","conversion_output":true,"text":"to the participant's treatment assignment. If the two adjudicators' classifications agree,","text_display":" to the participant's treatment assignment. If the two adjudicators' classifications agree,","confidence":1,"confidence_rate":1},{"cnt":[[305,945],[1807,945],[1807,993],[305,993]],"region":{"top_left_x":305,"top_left_y":945,"width":1502,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d730aab77e1487b99edd1d5b152cbb1","type":"text","conversion_output":true,"text":"then the classification will become final. Disagreements will be resolved at periodic face-","text_display":" then the classification will become final. Disagreements will be resolved at periodic face-","confidence":1,"confidence_rate":1},{"cnt":[[305,988],[1652,988],[1652,1038],[305,1038]],"region":{"top_left_x":305,"top_left_y":988,"width":1348,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1be8af5170948ce8f352aaf9bae8954","type":"text","conversion_output":true,"text":"to-face meetings or by phone conferences between adjudicators and additional","text_display":"to-face meetings or by phone conferences between adjudicators and additional","confidence":1,"confidence_rate":1},{"cnt":[[305,1033],[1800,1033],[1800,1081],[305,1081]],"region":{"top_left_x":305,"top_left_y":1033,"width":1496,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e47ab5e7a6f4872baea3e82f187c5ed","type":"text","conversion_output":true,"text":"members of the Adjudication Committee until consensus is achieved. These procedures","text_display":" members of the Adjudication Committee until consensus is achieved. These procedures","confidence":1,"confidence_rate":1},{"cnt":[[305,1079],[1691,1079],[1691,1124],[305,1124]],"region":{"top_left_x":305,"top_left_y":1078,"width":1386,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ed56370a15740e28e48e113fff5ffd4","type":"text","conversion_output":true,"text":"have been successfully used by our team in other large clinical trials including the","text_display":" have been successfully used by our team in other large clinical trials including the","confidence":1,"confidence_rate":1},{"cnt":[[305,1121],[1760,1121],[1760,1171],[305,1171]],"region":{"top_left_x":305,"top_left_y":1121,"width":1455,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9ecc00bfaec481d819b3ea07611852d","type":"text","conversion_output":true,"text":"Gingko Evaluation of Memory Study (GEMS) (DeKosky et al, 2008) and the Women's","text_display":" Gingko Evaluation of Memory Study (GEMS) (DeKosky et al, 2008) and the Women's","confidence":0.99951171875,"confidence_rate":0.999994115673962},{"cnt":[[305,1164],[1412,1164],[1412,1214],[305,1214]],"region":{"top_left_x":305,"top_left_y":1164,"width":1107,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d1951b8749b42da885e2acc5d1ed759","type":"text","conversion_output":true,"text":"Health Initiative Memory Study (WHIMS) (Shumaker et al, 2004).","text_display":" Health Initiative Memory Study (WHIMS) (Shumaker et al, 2004).","confidence":0.99755859375,"confidence_rate":0.9999635172126508},{"cnt":[[305,1250],[1704,1250],[1704,1300],[305,1300]],"region":{"top_left_x":305,"top_left_y":1250,"width":1399,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1c61e559309411a8dc1269ab1597754","type":"text","conversion_output":true,"text":"Participants classified as having dementia will no longer be assessed for cognitive","text_display":"\n\nParticipants classified as having dementia will no longer be assessed for cognitive","confidence":1,"confidence_rate":1},{"cnt":[[305,1298],[1717,1298],[1717,1345],[305,1345]],"region":{"top_left_x":305,"top_left_y":1297,"width":1412,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c7de5d8d5524069877993b7792d7ead","type":"text","conversion_output":true,"text":"function. Those not classified as having dementia will continue to receive regularly","text_display":" function. Those not classified as having dementia will continue to receive regularly","confidence":1,"confidence_rate":1},{"cnt":[[305,1341],[1764,1341],[1764,1388],[305,1388]],"region":{"top_left_x":305,"top_left_y":1340,"width":1459,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40ed72b8dd804bb6844d49449a50f443","type":"text","conversion_output":true,"text":"scheduled cognitive assessments with the screening and extended cognitive batteries","text_display":" scheduled cognitive assessments with the screening and extended cognitive batteries","confidence":1,"confidence_rate":1},{"cnt":[[305,1384],[580,1384],[580,1429],[305,1429]],"region":{"top_left_x":305,"top_left_y":1383,"width":276,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d0580a7b44042fe9301f4e21a63435d","type":"text","conversion_output":true,"text":"when indicated.","text_display":" when indicated.","confidence":1,"confidence_rate":1},{"cnt":[[301,1465],[1003,1465],[1003,1523],[301,1523]],"region":{"top_left_x":300,"top_left_y":1465,"width":704,"height":59},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7292dbf505634fa1a9024f35fadd85bf","type":"section_header","conversion_output":false,"children_ids":["5ed5545287ba434e8cfa4fe727450bd5"],"text":"","text_display":""},{"cnt":[[305,1470],[999,1470],[999,1519],[305,1519]],"region":{"top_left_x":305,"top_left_y":1469,"width":695,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ed5545287ba434e8cfa4fe727450bd5","type":"text","conversion_output":true,"parent_id":"7292dbf505634fa1a9024f35fadd85bf","text":"6.5.1 Diagnostic Criteria for Dementia","text_display":"\n\n\\subsection*{6.5.1 Diagnostic Criteria for Dementia}","confidence":0.99609375,"confidence_rate":0.9999089832278327},{"cnt":[[305,1551],[1704,1551],[1704,1601],[305,1601]],"region":{"top_left_x":305,"top_left_y":1551,"width":1399,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dfd1343e9794777b42d09094f9cfe04","type":"text","conversion_output":true,"text":"Criteria used for identifying dementia will be those described in the Diagnostic and","text_display":"\n\nCriteria used for identifying dementia will be those described in the Diagnostic and","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[305,1594],[1725,1594],[1725,1644],[305,1644]],"region":{"top_left_x":305,"top_left_y":1594,"width":1421,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"326af3b424de4c7189fa50d09e21ac54","type":"text","conversion_output":true,"text":"Statistical Manual of the American Psychiatric Association-Fourth Edition (DSM-IV).","text_display":" Statistical Manual of the American Psychiatric Association-Fourth Edition (DSM-IV).","confidence":1,"confidence_rate":1},{"cnt":[[305,1641],[501,1641],[501,1682],[305,1682]],"region":{"top_left_x":305,"top_left_y":1641,"width":196,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c422ae1b38134f71a47780f5040277db","type":"text","conversion_output":true,"text":"These are:","text_display":" These are:","confidence":1,"confidence_rate":1},{"cnt":[[402,1697],[1811,1697],[1811,1745],[402,1745]],"region":{"top_left_x":401,"top_left_y":1697,"width":1411,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2463667e4dd04de699d77a4abb48c100","type":"text","conversion_output":true,"text":"- Significant decline in memory and at least one additional cognitive domain; and","text_display":"\n- Significant decline in memory and at least one additional cognitive domain; and","confidence":1,"confidence_rate":1},{"cnt":[[402,1753],[1555,1753],[1555,1803],[402,1803]],"region":{"top_left_x":401,"top_left_y":1753,"width":1155,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9aa342902b1441f860b7745f1f5f373","type":"text","conversion_output":true,"text":"- Significant functional impairment due to cognitive problems; and","text_display":"\n- Significant functional impairment due to cognitive problems; and","confidence":1,"confidence_rate":1},{"cnt":[[402,1809],[1706,1809],[1706,1858],[402,1858]],"region":{"top_left_x":401,"top_left_y":1808,"width":1305,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"152ccb8a3e6d49f1af905878d4d1fc7f","type":"text","conversion_output":true,"text":"- Cognitive deficits are not due to obvious reversible causes such as acute","text_display":"\n- Cognitive deficits are not due to obvious reversible causes such as acute","confidence":1,"confidence_rate":1},{"cnt":[[460,1856],[1704,1856],[1704,1901],[460,1901]],"region":{"top_left_x":459,"top_left_y":1856,"width":1245,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d3b5e386dc64572964fe6bfbd8deef8","type":"text","conversion_output":true,"text":"illness, metabolic disturbances, infections, mood disorders or substance-","text_display":" illness, metabolic disturbances, infections, mood disorders or substance","confidence":1,"confidence_rate":1},{"cnt":[[460,1899],[1764,1899],[1764,1946],[460,1946]],"region":{"top_left_x":459,"top_left_y":1899,"width":1305,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"649bb32989244932b856ea34f2e824fd","type":"text","conversion_output":true,"text":"induced conditions; and cognitive deficits do not occur exclusively during the","text_display":"induced conditions; and cognitive deficits do not occur exclusively during the","confidence":1,"confidence_rate":1},{"cnt":[[460,1942],[784,1942],[784,1987],[460,1987]],"region":{"top_left_x":459,"top_left_y":1942,"width":326,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3c4f26fc8ea4534add08c2ad7671a09","type":"text","conversion_output":true,"text":"course of delirium.","text_display":" course of delirium.","confidence":1,"confidence_rate":1},{"cnt":[[305,1985],[1227,1985],[1227,2035],[305,2035]],"region":{"top_left_x":305,"top_left_y":1985,"width":922,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6573fda3bd5433e8883d16ee1c91df3","type":"text","conversion_output":true,"text":"No attempt to classify dementia subtype will be made.","text_display":"\nNo attempt to classify dementia subtype will be made.","confidence":1,"confidence_rate":1},{"cnt":[[301,2069],[922,2069],[922,2125],[301,2125]],"region":{"top_left_x":300,"top_left_y":2068,"width":622,"height":57},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96011ce45b8c405a92acdc86fccf4a78","type":"section_header","conversion_output":false,"children_ids":["6dca8409148c4f1abd6babb3cc368bed"],"text":"","text_display":""},{"cnt":[[305,2073],[917,2073],[917,2121],[305,2121]],"region":{"top_left_x":305,"top_left_y":2073,"width":613,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dca8409148c4f1abd6babb3cc368bed","type":"text","conversion_output":true,"parent_id":"96011ce45b8c405a92acdc86fccf4a78","text":"6.5.2 Diagnostic Criteria for MCI","text_display":"\n\n\\subsection*{6.5.2 Diagnostic Criteria for MCI}","confidence":0.9669159427830891,"confidence_rate":0.9991150309459167},{"cnt":[[305,2155],[1760,2155],[1760,2202],[305,2202]],"region":{"top_left_x":305,"top_left_y":2154,"width":1455,"height":49},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"596843b761bf429db8944952c1988865","type":"text","conversion_output":true,"text":"While not a primary or secondary outcome, MCl syndrome is important because of its","text_display":"\n\nWhile not a primary or secondary outcome, MCl syndrome is important because of its","confidence":0.86591761931777,"confidence_rate":0.9984531814003503},{"cnt":[[305,2200],[1676,2200],[1676,2245],[305,2245]],"region":{"top_left_x":305,"top_left_y":2200,"width":1371,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c092eedc98fe4f3d9f488440dea6db2f","type":"text","conversion_output":true,"text":"relevance to dementia. MCI represents a transitional state between no cognitive","text_display":" relevance to dementia. 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Thus, identifying MCI will provide valuable information about pre-","text_display":" subsequent dementia. Thus, identifying MCI will provide valuable information about pre","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[305,2329],[1772,2329],[1772,2378],[305,2378]],"region":{"top_left_x":305,"top_left_y":2328,"width":1468,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8ea7dfcdeb441568d02dd3a029b34ad","type":"text","conversion_output":true,"text":"dementia cognitive impairment related to the SPRINT intervention. Criteria to be used","text_display":"dementia cognitive impairment related to the SPRINT intervention. 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(Winblad et al, 2004) as follows:","text_display":" et AI. (Winblad et al, 2004) as follows:","confidence":0.8106074488023296,"confidence_rate":0.9953448384404695},{"cnt":[[301,664],[1712,664],[1712,1012],[301,1012]],"region":{"top_left_x":300,"top_left_y":663,"width":1413,"height":349},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7445f2a152c42b8b84fe444f9b9ac9e","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/0af9d5ab-703e-4ab1-bbab-51f070cc030a-045.jpg?height=349&width=1413&top_left_y=663&top_left_x=300)"},{"cnt":[[305,1042],[1779,1042],[1779,1091],[305,1091]],"region":{"top_left_x":305,"top_left_y":1041,"width":1474,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cb4930cfea649538e5dc8f8b70dcf8a","type":"text","conversion_output":true,"text":"Specific cognitive tests in the Cognition Screening Battery and the Extensive Cognitive","text_display":"\n\nSpecific cognitive tests in the Cognition Screening Battery and the Extensive Cognitive","confidence":0.9985356330871582,"confidence_rate":0.9999840714296225},{"cnt":[[305,1087],[1504,1087],[1504,1137],[305,1137]],"region":{"top_left_x":305,"top_left_y":1087,"width":1199,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1b18287a3af4dd5be559d3f95ec4576","type":"text","conversion_output":true,"text":"Assessment Battery will be used to subtype adjudicated cases of MCI.","text_display":" Assessment Battery will be used to subtype adjudicated cases of MCI.","confidence":0.9990234375,"confidence_rate":0.999986615984802},{"cnt":[[301,1169],[1164,1169],[1164,1227],[301,1227]],"region":{"top_left_x":300,"top_left_y":1168,"width":865,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ad061f6e3a64392b94361096dfc6702","type":"section_header","conversion_output":false,"children_ids":["9e6a171704fa47eba01f13fdc119d841"],"text":"","text_display":""},{"cnt":[[305,1173],[1160,1173],[1160,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":856,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6a171704fa47eba01f13fdc119d841","type":"text","conversion_output":true,"parent_id":"3ad061f6e3a64392b94361096dfc6702","text":"6.6 Baseline classification of cognitive status:","text_display":"\n\n\\subsection*{6.6 Baseline classification of cognitive status:}","confidence":0.9970703125,"confidence_rate":0.9999446432787533},{"cnt":[[305,1261],[1779,1261],[1779,1313],[305,1313]],"region":{"top_left_x":305,"top_left_y":1261,"width":1474,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"427145e9f798486fb5128f4f9834693b","type":"text","conversion_output":true,"text":"Rare cases of dementia, where the participant or their personal physician are unaware","text_display":"\n\nRare cases of dementia, where the participant or their personal physician are unaware","confidence":1,"confidence_rate":1},{"cnt":[[305,1308],[1721,1308],[1721,1354],[305,1354]],"region":{"top_left_x":305,"top_left_y":1308,"width":1416,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3103ba67bb14164a344ed08b695e5b5","type":"text","conversion_output":true,"text":"of the diagnosis, may be identified during baseline cognitive testing. In participants","text_display":" of the diagnosis, may be identified during baseline cognitive testing. In participants","confidence":1,"confidence_rate":1},{"cnt":[[305,1351],[1755,1351],[1755,1399],[305,1399]],"region":{"top_left_x":305,"top_left_y":1351,"width":1451,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf3299e6cab8469aabc10a1367e9b214","type":"text","conversion_output":true,"text":"scoring below the cut-point on the Screening Battery, we will administer the FAQ to a","text_display":" scoring below the cut-point on the Screening Battery, we will administer the FAQ to a","confidence":1,"confidence_rate":1},{"cnt":[[305,1396],[1803,1396],[1803,1446],[305,1446]],"region":{"top_left_x":305,"top_left_y":1396,"width":1498,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fba4ce3579824f939316886a52f0592c","type":"text","conversion_output":true,"text":"contact in order to determine the presence of impaired daily function related to cognition","text_display":" contact in order to determine the presence of impaired daily function related to cognition","confidence":1,"confidence_rate":1},{"cnt":[[305,1439],[509,1439],[509,1489],[305,1489]],"region":{"top_left_x":305,"top_left_y":1439,"width":205,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fab4971effa643adb2a8bcbb0f8105c5","type":"text","conversion_output":true,"text":"(see 6.4.2).","text_display":" (see 6.4.2).","confidence":1,"confidence_rate":1},{"cnt":[[301,1519],[1712,1519],[1712,1626],[301,1626]],"region":{"top_left_x":300,"top_left_y":1518,"width":1413,"height":109},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21ae9d75c0d34c77aeb3011b562f7d8c","type":"section_header","conversion_output":false,"children_ids":["601cd805388e4dbabc9a7ce6035c2b76","9ccf79e74857497e919911b76bc4fade"],"text":"","text_display":""},{"cnt":[[305,1525],[1704,1525],[1704,1575],[305,1575]],"region":{"top_left_x":305,"top_left_y":1525,"width":1399,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"601cd805388e4dbabc9a7ce6035c2b76","type":"text","conversion_output":true,"parent_id":"21ae9d75c0d34c77aeb3011b562f7d8c","text":"6.7 Definition of Cognitive Change Over Time Outcome (Extended Cognitive","text_display":"\n\n\\subsection*{6.7 Definition of Cognitive Change Over Time Outcome (Extended Cognitive","confidence":0.9980480668600649,"confidence_rate":0.9999746257681125},{"cnt":[[305,1568],[939,1568],[939,1620],[305,1620]],"region":{"top_left_x":305,"top_left_y":1568,"width":634,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ccf79e74857497e919911b76bc4fade","type":"text","conversion_output":true,"parent_id":"21ae9d75c0d34c77aeb3011b562f7d8c","text":"Assessment Battery Sub Sample).","text_display":" Assessment Battery Sub Sample).}","confidence":1,"confidence_rate":1},{"cnt":[[305,1659],[1699,1659],[1699,1708],[305,1708]],"region":{"top_left_x":305,"top_left_y":1658,"width":1395,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"032edc41637d49b2b5bda7e31d173d10","type":"text","conversion_output":true,"text":"Each test score from the Cognition Screening Battery and the Extended Cognitive","text_display":"\n\nEach test score from the Cognition Screening Battery and the Extended Cognitive","confidence":1,"confidence_rate":1},{"cnt":[[305,1702],[1785,1702],[1785,1751],[305,1751]],"region":{"top_left_x":305,"top_left_y":1701,"width":1481,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdbd4edc3c0248bd8e1f203b7e19a254","type":"text","conversion_output":true,"text":"Assessment Battery will be used to measure decline in cognitive function. The primary","text_display":" Assessment Battery will be used to measure decline in cognitive function. The primary","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1691,1745],[1691,1794],[305,1794]],"region":{"top_left_x":305,"top_left_y":1744,"width":1386,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ff34ac0d235461fa2062b1e79c466bf","type":"text","conversion_output":true,"text":"outcomes will be composite scores for two domains: 1) Memory, consisting of the","text_display":" outcomes will be composite scores for two domains: 1) Memory, consisting of the","confidence":0.96044921875,"confidence_rate":0.9995197086176797},{"cnt":[[305,1790],[1790,1790],[1790,1841],[305,1841]],"region":{"top_left_x":305,"top_left_y":1789,"width":1485,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f4fa5d3c93d417b97c53d17e1575349","type":"text","conversion_output":true,"text":"Hopkins Verbal Learning Test, Logical Memory and the Modified Rey Osterrieth Figure,","text_display":" Hopkins Verbal Learning Test, Logical Memory and the Modified Rey Osterrieth Figure,","confidence":1,"confidence_rate":1},{"cnt":[[305,1835],[1755,1835],[1755,1882],[305,1882]],"region":{"top_left_x":305,"top_left_y":1834,"width":1451,"height":49},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95095e4d8f9a4677bd5e8c7cd06ba444","type":"text","conversion_output":true,"text":"and 2) Processing Speed, consisting of Trails Making Tests and Digit Symbol Coding","text_display":" and 2) Processing Speed, consisting of Trails Making Tests and Digit Symbol Coding","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[305,1878],[1764,1878],[1764,1927],[305,1927]],"region":{"top_left_x":305,"top_left_y":1877,"width":1459,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ac230e8ca8040bead7fdc7c680ebd67","type":"text","conversion_output":true,"text":"Test. Prior to analysis of this outcome, we will review the science related to summary","text_display":" Test. Prior to analysis of this outcome, we will review the science related to summary","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1807,1921],[1807,1970],[305,1970]],"region":{"top_left_x":305,"top_left_y":1920,"width":1502,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e54229dfff84fbb88b2618b0227955a","type":"text","conversion_output":true,"text":"scores for cognitive function and may make modifications which will be specified prior to","text_display":" scores for cognitive function and may make modifications which will be specified prior to","confidence":1,"confidence_rate":1},{"cnt":[[305,1968],[724,1968],[724,2013],[305,2013]],"region":{"top_left_x":305,"top_left_y":1967,"width":420,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dbdbc88f7cb4992b005466b80a154d2","type":"text","conversion_output":true,"text":"initiation of the analysis.","text_display":" initiation of the analysis.","confidence":0.99951171875,"confidence_rate":0.9999847376009057},{"cnt":[[301,2047],[913,2047],[913,2108],[301,2108]],"region":{"top_left_x":300,"top_left_y":2047,"width":614,"height":61},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"affea81f167446e6b48857d597b2bb14","type":"section_header","conversion_output":false,"children_ids":["b05e4606ff5144b1a869c1fa8196e5aa"],"text":"","text_display":""},{"cnt":[[305,2052],[909,2052],[909,2103],[305,2103]],"region":{"top_left_x":305,"top_left_y":2051,"width":604,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b05e4606ff5144b1a869c1fa8196e5aa","type":"text","conversion_output":true,"parent_id":"affea81f167446e6b48857d597b2bb14","text":"6.8 Quality Control and Training","text_display":"\n\n\\subsection*{6.8 Quality Control and Training}","confidence":1,"confidence_rate":1},{"cnt":[[305,2140],[1734,2140],[1734,2189],[305,2189]],"region":{"top_left_x":305,"top_left_y":2139,"width":1429,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"603e17d6ef254c9a99085f6183a103ca","type":"text","conversion_output":true,"text":"At each clinical site, at least one person will be identified to serve as the trained and","text_display":"\n\nAt each clinical site, at least one person will be identified to serve as the trained and","confidence":1,"confidence_rate":1},{"cnt":[[305,2185],[1712,2185],[1712,2232],[305,2232]],"region":{"top_left_x":305,"top_left_y":2184,"width":1408,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80136499727d44d783b94e94e977d327","type":"text","conversion_output":true,"text":"certified cognitive technician. Technicians will be trained during a central, intensive","text_display":" certified cognitive technician. Technicians will be trained during a central, intensive","confidence":1,"confidence_rate":1},{"cnt":[[305,2230],[1697,2230],[1697,2277],[305,2277]],"region":{"top_left_x":305,"top_left_y":2230,"width":1393,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"149dc10acab545fb9ee729a8c282ed7a","type":"text","conversion_output":true,"text":"training session held in conjunction with the overall SPRINT training. Training will","text_display":" training session held in conjunction with the overall SPRINT training. Training will","confidence":1,"confidence_rate":1},{"cnt":[[305,2273],[1687,2273],[1687,2322],[305,2322]],"region":{"top_left_x":305,"top_left_y":2273,"width":1382,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5c389219116406db28a7b0f452a0980","type":"text","conversion_output":true,"text":"include review of the MIND protocol and procedures for administration of the test","text_display":" include review of the MIND protocol and procedures for administration of the test","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1764,2316],[1764,2365],[305,2365]],"region":{"top_left_x":305,"top_left_y":2316,"width":1459,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd743184f838487988e3e099862a800d","type":"text","conversion_output":true,"text":"batteries, demonstrations of each component of the SPRINT MIND test batteries, and","text_display":" batteries, demonstrations of each component of the SPRINT MIND test batteries, and","confidence":1,"confidence_rate":1},{"cnt":[[305,2359],[1747,2359],[1747,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1442,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"083f17b36eea4a55b3e333f32591cb58","type":"text","conversion_output":true,"text":"opportunities to practice with feedback from trainers. When a level of competence is","text_display":" opportunities to practice with feedback from trainers. 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For Spanish-speaking participants, Spanish versions of all HRQL instruments will","text_display":" visit. 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The two primary","text_display":" cardiovascular events but will be more cost-effective over the long-term. 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Costs will","confidence":0.99755859375,"confidence_rate":0.9999748004067751},{"cnt":[[309,1396],[1446,1396],[1446,1437],[309,1437]],"region":{"top_left_x":309,"top_left_y":1396,"width":1137,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbeb7842f41047ea8bfd6d320604ca0a","type":"text","conversion_output":true,"text":"be discounted to weigh future costs less heavily than present ones.","text_display":" be discounted to weigh future costs less heavily than present ones.","confidence":1,"confidence_rate":1},{"cnt":[[305,1478],[690,1478],[690,1523],[305,1523]],"region":{"top_left_x":305,"top_left_y":1478,"width":385,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad6fcf75ba7b4e8a9887934c06dda9f0","type":"section_header","conversion_output":false,"children_ids":["49744db593a545849de671f7c4a3a8e8"],"text":"","text_display":""},{"cnt":[[309,1482],[685,1482],[685,1519],[309,1519]],"region":{"top_left_x":309,"top_left_y":1482,"width":377,"height":37},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49744db593a545849de671f7c4a3a8e8","type":"text","conversion_output":true,"parent_id":"ad6fcf75ba7b4e8a9887934c06dda9f0","text":"7.4.2 Effectiveness","text_display":"\n\n\\subsection*{7.4.2 Effectiveness}","confidence":1,"confidence_rate":1},{"cnt":[[309,1571],[1721,1571],[1721,1613],[309,1613]],"region":{"top_left_x":309,"top_left_y":1570,"width":1412,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06b5fd274cdd41acb8f8b39dab4637cd","type":"text","conversion_output":true,"text":"The primary endpoints defined by the main trial are considered as primary outcome","text_display":"\n\nThe primary endpoints defined by the main trial are considered as primary outcome","confidence":1,"confidence_rate":1},{"cnt":[[309,1616],[1794,1616],[1794,1656],[309,1656]],"region":{"top_left_x":309,"top_left_y":1615,"width":1485,"height":42},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8d3e48b7b1745199ffa6ce56c00a6f7","type":"text","conversion_output":true,"text":"measures for this economic evaluation. The primary effectiveness measures will be life-","text_display":" measures for this economic evaluation. The primary effectiveness measures will be life","confidence":1,"confidence_rate":1},{"cnt":[[309,1659],[1760,1659],[1760,1704],[309,1704]],"region":{"top_left_x":309,"top_left_y":1658,"width":1451,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4ca5fdc7c674a61918cf6a9adbc2661","type":"text","conversion_output":true,"text":"years gained and QALY gained. The measure of life-year gained is determined by the","text_display":"years gained and QALY gained. The measure of life-year gained is determined by the","confidence":1,"confidence_rate":1},{"cnt":[[309,1702],[1714,1702],[1714,1747],[309,1747]],"region":{"top_left_x":309,"top_left_y":1701,"width":1406,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"975f5d101a454b6991fed9ae29f7e403","type":"text","conversion_output":true,"text":"difference in number of life-years between intensive therapy and standard therapy.","text_display":" difference in number of life-years between intensive therapy and standard therapy.","confidence":1,"confidence_rate":1},{"cnt":[[309,1745],[1751,1745],[1751,1790],[309,1790]],"region":{"top_left_x":309,"top_left_y":1744,"width":1442,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02489737b32349afa4ccb18814a4c021","type":"text","conversion_output":true,"text":"QALYs adjust life-years gained by the quality of the participant's overall HRQL during","text_display":" QALYs adjust life-years gained by the quality of the participant's overall HRQL during","confidence":1,"confidence_rate":1},{"cnt":[[309,1792],[707,1792],[707,1833],[309,1833]],"region":{"top_left_x":309,"top_left_y":1791,"width":398,"height":42},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f39d5da6b6546df89b96f06bd010081","type":"text","conversion_output":true,"text":"these life-years gained.","text_display":" these life-years gained.","confidence":0.9990234375,"confidence_rate":0.9999663095451973},{"cnt":[[305,1873],[518,1873],[518,1916],[305,1916]],"region":{"top_left_x":305,"top_left_y":1873,"width":213,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1294bc31ee2045e7b0d35bbef285eaba","type":"section_header","conversion_output":false,"children_ids":["a85fcf852d714288921cc736832dab1e"],"text":"","text_display":""},{"cnt":[[309,1878],[518,1878],[518,1914],[309,1914]],"region":{"top_left_x":309,"top_left_y":1877,"width":209,"height":38},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a85fcf852d714288921cc736832dab1e","type":"text","conversion_output":true,"parent_id":"1294bc31ee2045e7b0d35bbef285eaba","text":"7.4.3 Costs","text_display":"\n\n\\subsection*{7.4.3 Costs}","confidence":1,"confidence_rate":1},{"cnt":[[309,1964],[1783,1964],[1783,2009],[309,2009]],"region":{"top_left_x":309,"top_left_y":1963,"width":1475,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e4964ca5e404a368c11c5783cc41fd1","type":"text","conversion_output":true,"text":"All direct medical costs associated with treatment of hypertension and its complications","text_display":"\n\nAll direct medical costs associated with treatment of hypertension and its complications","confidence":1,"confidence_rate":1},{"cnt":[[309,2007],[1790,2007],[1790,2052],[309,2052]],"region":{"top_left_x":309,"top_left_y":2006,"width":1481,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ed21a42bca84f62b417ee317e5b832c","type":"text","conversion_output":true,"text":"and costs for treating adverse effects of the therapy will be considered. These costs will","text_display":" and costs for treating adverse effects of the therapy will be considered. These costs will","confidence":1,"confidence_rate":1},{"cnt":[[309,2054],[1669,2054],[1669,2095],[309,2095]],"region":{"top_left_x":309,"top_left_y":2053,"width":1361,"height":42},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5785dd71d01c4e77a952ea0a6780f8fc","type":"text","conversion_output":true,"text":"include costs of inpatient care, outpatient care, medications, medical equipment,","text_display":" include costs of inpatient care, outpatient care, medications, medical equipment,","confidence":1,"confidence_rate":1},{"cnt":[[309,2097],[1732,2097],[1732,2142],[309,2142]],"region":{"top_left_x":309,"top_left_y":2096,"width":1423,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73279c78aef84d11abcecdb5615f0e09","type":"text","conversion_output":true,"text":"supplies, laboratory tests, and professional services. The participant's costs such as","text_display":" supplies, laboratory tests, and professional services. The participant's costs such as","confidence":1,"confidence_rate":1},{"cnt":[[309,2140],[1777,2140],[1777,2185],[309,2185]],"region":{"top_left_x":309,"top_left_y":2139,"width":1468,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5446b4d8c0a4851be08679a53d04927","type":"text","conversion_output":true,"text":"waiting time, transportation, lodging, and informal care arising from the disease will not","text_display":" waiting time, transportation, lodging, and informal care arising from the disease will not","confidence":1,"confidence_rate":1},{"cnt":[[309,2185],[1794,2185],[1794,2228],[309,2228]],"region":{"top_left_x":309,"top_left_y":2184,"width":1485,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d90491a473945f999107c77a147e65c","type":"text","conversion_output":true,"text":"be included. Likewise, opportunity costs of premature death, productivity loss, and long-","text_display":" be included. Likewise, opportunity costs of premature death, productivity loss, and long","confidence":1,"confidence_rate":1},{"cnt":[[309,2230],[1147,2230],[1147,2273],[309,2273]],"region":{"top_left_x":309,"top_left_y":2230,"width":839,"height":44},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1a5fddefe384628a29a748e441f2c56","type":"text","conversion_output":true,"text":"term disability will not be considered in this study.","text_display":"term disability will not be considered in this study.","confidence":1,"confidence_rate":1},{"cnt":[[305,2445],[819,2445],[819,2488],[305,2488]],"region":{"top_left_x":305,"top_left_y":2444,"width":514,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9942503ea33f41ca879fba1912c5a8a8","type":"section_header","conversion_output":false,"children_ids":["0b6ff783e323443a92f8b25aecfea2ee"],"text":"","text_display":""},{"cnt":[[309,2449],[814,2449],[814,2486],[309,2486]],"region":{"top_left_x":309,"top_left_y":2449,"width":506,"height":37},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b6ff783e323443a92f8b25aecfea2ee","type":"text","conversion_output":true,"parent_id":"9942503ea33f41ca879fba1912c5a8a8","text":"7.4.3.1 Cost Data Collection","text_display":"\n\n\\subsection*{7.4.3.1 Cost Data Collection}","confidence":1,"confidence_rate":1},{"cnt":[[309,2638],[488,2638],[488,2671],[309,2671]],"region":{"top_left_x":309,"top_left_y":2638,"width":179,"height":33},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47bd1330720d4b08aa1157444852b5f0","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a96cb9dd4666421bb1c01b1dd684251e","type":"page_info","conversion_output":false,"text":"48","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1525,2638],[1815,2638],[1815,2675],[1525,2675]],"region":{"top_left_x":1525,"top_left_y":2638,"width":291,"height":37},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79057be0f8d84f59b3aba78ebe16a2fe","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-051","page":51,"lines":[{"cnt":[[309,296],[1755,296],[1755,342],[309,342]],"region":{"top_left_x":309,"top_left_y":296,"width":1447,"height":46},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9092d6b733ef42dc9aa2c11843e83dbb","type":"text","conversion_output":true,"text":"Hospitalizations are the primary cost drivers in most cost-effectiveness analyses, and","text_display":"\n\nHospitalizations are the primary cost drivers in most cost-effectiveness analyses, and","confidence":1,"confidence_rate":1},{"cnt":[[309,339],[1738,339],[1738,385],[309,385]],"region":{"top_left_x":309,"top_left_y":339,"width":1430,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73834a276b8a47e288a2caa0e0ac7d8e","type":"text","conversion_output":true,"text":"SPRINT has proposed obtaining hospitalization events via multiple sources. Patient","text_display":" SPRINT has proposed obtaining hospitalization events via multiple sources. Patient","confidence":1,"confidence_rate":1},{"cnt":[[309,385],[1661,385],[1661,428],[309,428]],"region":{"top_left_x":309,"top_left_y":384,"width":1352,"height":44},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d27c221353d340ec9851ad7a8e7cd2f2","type":"text","conversion_output":true,"text":"report of hospitalizations, along with emergency department (ED) visits, stays in","text_display":" report of hospitalizations, along with emergency department (ED) visits, stays in","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[309,430],[1798,430],[1798,475],[309,475]],"region":{"top_left_x":309,"top_left_y":429,"width":1490,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d650fa595e634a35b7920780d1ad947b","type":"text","conversion_output":true,"text":"rehabilitation facilities, and day-surgery admissions, are obtained every 3 months during","text_display":" rehabilitation facilities, and day-surgery admissions, are obtained every 3 months during","confidence":1,"confidence_rate":1},{"cnt":[[309,473],[1708,473],[1708,516],[309,516]],"region":{"top_left_x":309,"top_left_y":472,"width":1400,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e1f72d8d5344b5dbbede38eaeb79532","type":"text","conversion_output":true,"text":"scheduled SPRINT study visits. Discharge summaries and other pertinent records","text_display":" scheduled SPRINT study visits. 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Because of","text_display":" constitute many of the admissions that might be expected to differ by arm. Because of","confidence":1,"confidence_rate":1},{"cnt":[[309,735],[1721,735],[1721,780],[309,780]],"region":{"top_left_x":309,"top_left_y":734,"width":1412,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06b8243d7ed64335bbc820f57125bb1f","type":"text","conversion_output":true,"text":"the large proportion of VA and Medicare patients in SPRINT, we also will be able to","text_display":" the large proportion of VA and Medicare patients in SPRINT, we also will be able to","confidence":1,"confidence_rate":1},{"cnt":[[309,780],[1794,780],[1794,823],[309,823]],"region":{"top_left_x":309,"top_left_y":779,"width":1485,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e11fd4d7e284605b9badbc5c401d041","type":"text","conversion_output":true,"text":"determine hospitalizations, dates of admission, length of stay, and reason for admission","text_display":" determine hospitalizations, dates of admission, length of stay, and reason for admission","confidence":1,"confidence_rate":1},{"cnt":[[309,825],[1721,825],[1721,866],[309,866]],"region":{"top_left_x":309,"top_left_y":825,"width":1412,"height":41},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e632c77f1e734400b21b38a6db7aa34a","type":"text","conversion_output":true,"text":"via Medicare and VA databases for those hospitalizations for which we do not have","text_display":" via Medicare and VA databases for those hospitalizations for which we do not have","confidence":1,"confidence_rate":1},{"cnt":[[309,868],[1790,868],[1790,913],[309,913]],"region":{"top_left_x":309,"top_left_y":867,"width":1481,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b7e0b098dc9475cacef6b1f6b0cfcc2","type":"text","conversion_output":true,"text":"discharge summaries. For the limited number of remaining patient reports for which we","text_display":" discharge summaries. For the limited number of remaining patient reports for which we","confidence":1,"confidence_rate":1},{"cnt":[[309,911],[1798,911],[1798,956],[309,956]],"region":{"top_left_x":309,"top_left_y":910,"width":1490,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1829a2ca49054ed09cba478ccbe7fab5","type":"text","conversion_output":true,"text":"have neither discharge summaries nor database information, we will perform regression","text_display":" have neither discharge summaries nor database information, we will perform regression","confidence":1,"confidence_rate":1},{"cnt":[[309,956],[1751,956],[1751,999],[309,999]],"region":{"top_left_x":309,"top_left_y":956,"width":1442,"height":44},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"390afc59c87f45c793dee2d3d07d462f","type":"text","conversion_output":true,"text":"analyses of reported vs. actual length of stay and costs for all those with such data to","text_display":" analyses of reported vs. actual length of stay and costs for all those with such data to","confidence":1,"confidence_rate":1},{"cnt":[[309,1001],[1605,1001],[1605,1042],[309,1042]],"region":{"top_left_x":309,"top_left_y":1001,"width":1296,"height":41},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f30a2c3026d946c290e5e056b6e145b0","type":"text","conversion_output":true,"text":"estimate the costs of the undocumented hospitalizations. Cost estimates for","text_display":" estimate the costs of the undocumented hospitalizations. Cost estimates for","confidence":1,"confidence_rate":1},{"cnt":[[309,1044],[1790,1044],[1790,1087],[309,1087]],"region":{"top_left_x":309,"top_left_y":1044,"width":1481,"height":44},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a77e96022b4d47a0be7c94d94f67bfbd","type":"text","conversion_output":true,"text":"hospitalizations will be based on DRG-specific Medicare cost weights. For professional","text_display":" hospitalizations will be based on DRG-specific Medicare cost weights. For professional","confidence":1,"confidence_rate":1},{"cnt":[[309,1087],[1781,1087],[1781,1130],[309,1130]],"region":{"top_left_x":309,"top_left_y":1087,"width":1473,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de4d89335dd744018836c3b1a6ee5f64","type":"text","conversion_output":true,"text":"costs associated with hospitalizations we plan to obtain these costs from Medicare and","text_display":" costs associated with hospitalizations we plan to obtain these costs from Medicare and","confidence":1,"confidence_rate":1},{"cnt":[[309,1130],[1781,1130],[1781,1175],[309,1175]],"region":{"top_left_x":309,"top_left_y":1130,"width":1473,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aba1e8c03b824205a0c71066e291f2d5","type":"text","conversion_output":true,"text":"VA databases as available in a subsample and use these data to estimate professional","text_display":" VA databases as available in a subsample and use these data to estimate professional","confidence":1,"confidence_rate":1},{"cnt":[[309,1175],[1760,1175],[1760,1218],[309,1218]],"region":{"top_left_x":309,"top_left_y":1175,"width":1451,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f71bdc6521c46c8be0d43905761a211","type":"text","conversion_output":true,"text":"costs for the entire sample based on these subsample analyses. We will also explore","text_display":" costs for the entire sample based on these subsample analyses. We will also explore","confidence":1,"confidence_rate":1},{"cnt":[[309,1220],[1729,1220],[1729,1261],[309,1261]],"region":{"top_left_x":309,"top_left_y":1220,"width":1421,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20bb94798b7143a19be295471a501d11","type":"text","conversion_output":true,"text":"whether these databases allow us to obtain costs associated with ED visits, stays in","text_display":" whether these databases allow us to obtain costs associated with ED visits, stays in","confidence":0.998046875,"confidence_rate":0.9999780335577174},{"cnt":[[309,1263],[1184,1263],[1184,1308],[309,1308]],"region":{"top_left_x":309,"top_left_y":1263,"width":875,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"141690c1f89d4c5295dbb6053661bbae","type":"text","conversion_output":true,"text":"rehabilitation facilities, and day surgery admissions.","text_display":" rehabilitation facilities, and day surgery admissions.","confidence":1,"confidence_rate":1},{"cnt":[[305,1345],[1412,1345],[1412,1396],[305,1396]],"region":{"top_left_x":305,"top_left_y":1344,"width":1107,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28c63b485ed945a6b3d7829b37cb528d","type":"section_header","conversion_output":false,"children_ids":["da21b2a52126433cb96eb20131269d72"],"text":"","text_display":""},{"cnt":[[309,1349],[1407,1349],[1407,1394],[309,1394]],"region":{"top_left_x":309,"top_left_y":1349,"width":1099,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da21b2a52126433cb96eb20131269d72","type":"text","conversion_output":true,"parent_id":"28c63b485ed945a6b3d7829b37cb528d","text":"7.4.3.2 Intensive and Standard Therapy Non-Research Costs","text_display":"\n\n\\subsection*{7.4.3.2 Intensive and Standard Therapy Non-Research Costs}","confidence":1,"confidence_rate":1},{"cnt":[[309,1439],[1669,1439],[1669,1480],[309,1480]],"region":{"top_left_x":309,"top_left_y":1439,"width":1361,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2be4cb94f6c941ce810f1e81c06442e5","type":"text","conversion_output":true,"text":"For medications, we plan to use study medication logs to obtain the medications","text_display":"\n\nFor medications, we plan to use study medication logs to obtain the medications","confidence":1,"confidence_rate":1},{"cnt":[[309,1482],[1738,1482],[1738,1525],[309,1525]],"region":{"top_left_x":309,"top_left_y":1482,"width":1430,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5559b2cb921a4040b7759e28669afe4f","type":"text","conversion_output":true,"text":"prescribed by the study. This log also includes blood pressure lowering medications","text_display":" prescribed by the study. This log also includes blood pressure lowering medications","confidence":1,"confidence_rate":1},{"cnt":[[309,1525],[1708,1525],[1708,1571],[309,1571]],"region":{"top_left_x":309,"top_left_y":1525,"width":1400,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34088152028749ebb767aa93ae88386a","type":"text","conversion_output":true,"text":"prescribed by other healthcare providers. Medication costs will be estimated using","text_display":" prescribed by other healthcare providers. Medication costs will be estimated using","confidence":1,"confidence_rate":1},{"cnt":[[309,1571],[1601,1571],[1601,1613],[309,1613]],"region":{"top_left_x":309,"top_left_y":1570,"width":1292,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53d21993c81141a79e7ade198a28b9cb","type":"text","conversion_output":true,"text":"median wholesale price. We will obtain information on non-study prescribed","text_display":" median wholesale price. We will obtain information on non-study prescribed","confidence":1,"confidence_rate":1},{"cnt":[[309,1616],[1815,1616],[1815,1656],[309,1656]],"region":{"top_left_x":309,"top_left_y":1615,"width":1507,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68f9c68adef7471b898fb523efaed28e","type":"text","conversion_output":true,"text":"medications (concomitant medications) from participants annually and will estimate costs","text_display":" medications (concomitant medications) from participants annually and will estimate costs","confidence":1,"confidence_rate":1},{"cnt":[[309,1659],[1794,1659],[1794,1704],[309,1704]],"region":{"top_left_x":309,"top_left_y":1658,"width":1485,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13bd6ff597a54958b5547c92870dbf11","type":"text","conversion_output":true,"text":"for these medications based on the most commonly used doses in clinical practice. We","text_display":" for these medications based on the most commonly used doses in clinical practice. We","confidence":1,"confidence_rate":1},{"cnt":[[309,1702],[1725,1702],[1725,1747],[309,1747]],"region":{"top_left_x":309,"top_left_y":1701,"width":1417,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d17218fa50d4ea6a5e9a7ca2cafff94","type":"text","conversion_output":true,"text":"will not obtain cost data on non-study related labs, as this source of utilization is not","text_display":" will not obtain cost data on non-study related labs, as this source of utilization is not","confidence":1,"confidence_rate":1},{"cnt":[[309,1747],[1732,1747],[1732,1790],[309,1790]],"region":{"top_left_x":309,"top_left_y":1746,"width":1423,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cf39b2924fc4620b887df00fb4f480a","type":"text","conversion_output":true,"text":"expected to differ by group. To estimate non-research related costs for the SPRINT","text_display":" expected to differ by group. To estimate non-research related costs for the SPRINT","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[309,1792],[1781,1792],[1781,1833],[309,1833]],"region":{"top_left_x":309,"top_left_y":1791,"width":1473,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2bacc84448341d6b84956850d694054","type":"text","conversion_output":true,"text":"office visits, we plan to obtain estimated CPT codes (minus research-specific activities)","text_display":" office visits, we plan to obtain estimated CPT codes (minus research-specific activities)","confidence":1,"confidence_rate":1},{"cnt":[[309,1835],[1687,1835],[1687,1871],[309,1871]],"region":{"top_left_x":309,"top_left_y":1834,"width":1378,"height":38},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c10c0f6129284a01a445348ff53ffcd2","type":"text","conversion_output":true,"text":"from clinic staff for a random subset of these visits to estimate costs via Medicare","text_display":" from clinic staff for a random subset of these visits to estimate costs via Medicare","confidence":1,"confidence_rate":1},{"cnt":[[309,1878],[1811,1878],[1811,1923],[309,1923]],"region":{"top_left_x":309,"top_left_y":1877,"width":1503,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bb8250bb2c94554820bf3ad1647edd1","type":"text","conversion_output":true,"text":"payment rates. Non-study outpatient visits will not be obtained but will be estimated with","text_display":" payment rates. Non-study outpatient visits will not be obtained but will be estimated with","confidence":0.9990234375,"confidence_rate":0.9999897154250147},{"cnt":[[309,1921],[1652,1921],[1652,1966],[309,1966]],"region":{"top_left_x":309,"top_left_y":1920,"width":1344,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b47d5400620d413f851cad87546ea257","type":"text","conversion_output":true,"text":"non-study medication costs by age using national health care expenditure data.","text_display":" non-study medication costs by age using national health care expenditure data.","confidence":1,"confidence_rate":1},{"cnt":[[305,2007],[1111,2007],[1111,2056],[305,2056]],"region":{"top_left_x":305,"top_left_y":2006,"width":806,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bee7bc5a94f433d824a67897842f158","type":"section_header","conversion_output":false,"children_ids":["e81618566152478e8a67f506855b3b53"],"text":"","text_display":""},{"cnt":[[309,2011],[1109,2011],[1109,2052],[309,2052]],"region":{"top_left_x":309,"top_left_y":2010,"width":800,"height":42},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e81618566152478e8a67f506855b3b53","type":"text","conversion_output":true,"parent_id":"4bee7bc5a94f433d824a67897842f158","text":"7.4.3.3 Data Analysis for Cost-Effectiveness","text_display":"\n\n\\subsection*{7.4.3.3 Data Analysis for Cost-Effectiveness}","confidence":0.9990234375,"confidence_rate":0.9999800606141427},{"cnt":[[309,2097],[1803,2097],[1803,2142],[309,2142]],"region":{"top_left_x":309,"top_left_y":2096,"width":1494,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a012c6f4b594ea9b4fb16c63336c967","type":"text","conversion_output":true,"text":"Two methods of cost-effectiveness analysis (CEA) and cost-utility analysis (CUA) will be","text_display":"\n\nTwo methods of cost-effectiveness analysis (CEA) and cost-utility analysis (CUA) will be","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[309,2142],[1781,2142],[1781,2179],[309,2179]],"region":{"top_left_x":309,"top_left_y":2141,"width":1473,"height":38},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccf9f3dd3d6e464397a95a4d7fcfef48","type":"text","conversion_output":true,"text":"used in the economic evaluation. The ratios of cost to outcome derived from CEA/CUA","text_display":" used in the economic evaluation. The ratios of cost to outcome derived from CEA/CUA","confidence":1,"confidence_rate":1},{"cnt":[[309,2187],[1734,2187],[1734,2228],[309,2228]],"region":{"top_left_x":309,"top_left_y":2187,"width":1425,"height":41},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8389009cc05a4cd6a8b47283b2cbf26c","type":"text","conversion_output":true,"text":"are used to compare cost-effectiveness among treatment strategies. An incremental","text_display":" are used to compare cost-effectiveness among treatment strategies. An incremental","confidence":1,"confidence_rate":1},{"cnt":[[309,2230],[1807,2230],[1807,2273],[309,2273]],"region":{"top_left_x":309,"top_left_y":2230,"width":1498,"height":44},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8641372fa3648b0a068f9b7d64c8dde","type":"text","conversion_output":true,"text":"cost-effectiveness ratio (ICER) will be calculated, which provides a summary of the cost-","text_display":" cost-effectiveness ratio (ICER) will be calculated, which provides a summary of the cost","confidence":0.998046875,"confidence_rate":0.9999792019733479},{"cnt":[[309,2273],[1210,2273],[1210,2310],[309,2310]],"region":{"top_left_x":309,"top_left_y":2273,"width":901,"height":37},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccf5e35f3ceb499e9b6158e3bdce2964","type":"text","conversion_output":true,"text":"effectiveness of one intervention relative to the other.","text_display":"effectiveness of one intervention relative to the other.","confidence":1,"confidence_rate":1},{"cnt":[[309,2638],[490,2638],[490,2671],[309,2671]],"region":{"top_left_x":309,"top_left_y":2638,"width":181,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0acad89cbbe740f8bcccd8c70fb29d5f","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6981c1d11f694523b63b6df2e4a68705","type":"page_info","conversion_output":false,"text":"49","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1525,2638],[1815,2638],[1815,2675],[1525,2675]],"region":{"top_left_x":1525,"top_left_y":2638,"width":291,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fed94920ccef423baec26aac61f5a560","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-052","page":52,"lines":[{"cnt":[[305,249],[1669,249],[1669,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1365,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c24c33db1fbe4e1b838f940c39afd34a","type":"text","conversion_output":true,"text":"The basic formula to calculate incremental CEA ratio and CUA ratio of a specific","text_display":"\n\nThe basic formula to calculate incremental CEA ratio and CUA ratio of a specific","confidence":1,"confidence_rate":1},{"cnt":[[305,296],[1571,296],[1571,342],[305,342]],"region":{"top_left_x":305,"top_left_y":296,"width":1266,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9eec96a44ea4de48d39bc8c0c36bb87","type":"text","conversion_output":true,"text":"treatment A relative to the reference treatment B is presented as following:","text_display":" treatment A relative to the reference treatment B is presented as following:","confidence":0.67919921875,"confidence_rate":0.9952355737838189},{"cnt":[[432,380],[1442,380],[1442,608],[432,608]],"region":{"top_left_x":431,"top_left_y":380,"width":1011,"height":229},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec5d6c8c0f544a22bd0608425f9628d6","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/0af9d5ab-703e-4ab1-bbab-51f070cc030a-052.jpg?height=229&width=1011&top_left_y=380&top_left_x=431)"},{"cnt":[[305,645],[1790,645],[1790,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1485,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c23413c6df544a8e997a4b2eaf9acef8","type":"text","conversion_output":true,"text":"The ratio of incremental cost to incremental effectiveness represents cost-effectiveness","text_display":"\n\nThe ratio of incremental cost to incremental effectiveness represents cost-effectiveness","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[1760,692],[1760,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1455,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac8f883b817d4b598cf56b0d1c1a89df","type":"text","conversion_output":true,"text":"of the intensive BP treatment. Bootstrap methods will be used to calculate confidence","text_display":" of the intensive BP treatment. Bootstrap methods will be used to calculate confidence","confidence":1,"confidence_rate":1},{"cnt":[[307,735],[1813,735],[1813,782],[307,782]],"region":{"top_left_x":307,"top_left_y":734,"width":1507,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fc13af3af51485fad9a38cf5725d209","type":"text","conversion_output":true,"text":"intervals for cost-effectiveness ratios. All costs will be adjusted to the baseline year using","text_display":" intervals for cost-effectiveness ratios. All costs will be adjusted to the baseline year using","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1807,778],[1807,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1502,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"014c9d8d942344efb3f43a0f0a79785a","type":"text","conversion_output":true,"text":"the medical component of the Consumer Price Index. Future costs and outcomes will be","text_display":" the medical component of the Consumer Price Index. Future costs and outcomes will be","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[305,821],[1794,821],[1794,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1489,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b805a9ca47d450384e680266b67afa7","type":"text","conversion_output":true,"text":"discounted by \\(3 \\%\\). Estimates of utilization over time will be adjusted for the presence of","text_display":" discounted by \\(3 \\%\\). Estimates of utilization over time will be adjusted for the presence of","confidence":1,"confidence_rate":1},{"cnt":[[305,866],[1699,866],[1699,913],[305,913]],"region":{"top_left_x":305,"top_left_y":865,"width":1395,"height":49},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a601bef13f4b47ccbc30e7d1e0b52ddd","type":"text","conversion_output":true,"text":"censored data with variable follow-up. Sensitivity analysis will explore the effect of","text_display":" censored data with variable follow-up. Sensitivity analysis will explore the effect of","confidence":1,"confidence_rate":1},{"cnt":[[305,911],[1807,911],[1807,956],[305,956]],"region":{"top_left_x":305,"top_left_y":910,"width":1502,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d347078819814a51abf2d127258cf20c","type":"text","conversion_output":true,"text":"correlations between costs and outcomes, which will also be empirically examined in the","text_display":" correlations between costs and outcomes, which will also be empirically examined in the","confidence":1,"confidence_rate":1},{"cnt":[[305,954],[711,954],[711,999],[305,999]],"region":{"top_left_x":305,"top_left_y":953,"width":407,"height":47},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c945717fb2e84b9b9cd027a4a227d3ed","type":"text","conversion_output":true,"text":"cost and outcome data.","text_display":" cost and outcome data.","confidence":1,"confidence_rate":1},{"cnt":[[305,1040],[1721,1040],[1721,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1416,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b53f31d3e7e34c1291f25b8e4538eee5","type":"text","conversion_output":true,"text":"QALYs will be calculated by summing the area under each individual's QALY curve","text_display":"\n\nQALYs will be calculated by summing the area under each individual's QALY curve","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[305,1087],[1717,1087],[1717,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":1412,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b26576b448da4dfa8614a177e5a8b736","type":"text","conversion_output":true,"text":"(constructed by plotting the EQ-5D scores for each interview during follow-up). The","text_display":" (constructed by plotting the EQ-5D scores for each interview during follow-up). The","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1794,1130],[1794,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1489,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dd31ddb70b1440bafadeb29ccf6e4b6","type":"text","conversion_output":true,"text":"estimates of mean differences in costs and outcomes - which will be used to create net","text_display":" estimates of mean differences in costs and outcomes - which will be used to create net","confidence":1,"confidence_rate":1},{"cnt":[[305,1173],[1669,1173],[1669,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1365,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e1478cf7a27417fa1d6f4878a776de6","type":"text","conversion_output":true,"text":"health benefits and the cost per QALY ratios -- will be derived from multivariable","text_display":" health benefits and the cost per QALY ratios -- will be derived from multivariable","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[1676,1216],[1676,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1371,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffd6684dd512405d812ecd33ae88397c","type":"text","conversion_output":true,"text":"regression analyses. For the evaluation of the difference in costs, the dependent","text_display":" regression analyses. For the evaluation of the difference in costs, the dependent","confidence":1,"confidence_rate":1},{"cnt":[[305,1261],[1807,1261],[1807,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1261,"width":1502,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e50e28c9e11e45c5b7cb96dd11b984d6","type":"text","conversion_output":true,"text":"variable in the regression will either be costs or the natural log of costs (determination of","text_display":" variable in the regression will either be costs or the natural log of costs (determination of","confidence":1,"confidence_rate":1},{"cnt":[[305,1306],[1790,1306],[1790,1354],[305,1354]],"region":{"top_left_x":305,"top_left_y":1306,"width":1485,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5669176282bb4fdbafebeb9794c26e4b","type":"text","conversion_output":true,"text":"the form of the dependent variable will be based on statistical tests of its distribution). If","text_display":" the form of the dependent variable will be based on statistical tests of its distribution). 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SPRINT adjudicators will be guided by specific, pre-specified","text_display":" therapy or procedure. SPRINT adjudicators will be guided by specific, pre-specified","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[309,1813],[1772,1813],[1772,1858],[309,1858]],"region":{"top_left_x":309,"top_left_y":1813,"width":1464,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed1b84b44b0c4c3cb9dd32f2fe1c1181","type":"text","conversion_output":true,"text":"definitions and operational rules. Adjudicators will use their clinical interpretation of the","text_display":" definitions and operational rules. 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ischemic ECG changes or imaging findings on exercise or","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1764,382],[1764,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1459,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bc2e297544b4413a0be2e608aa8fce0","type":"text","conversion_output":true,"text":"pharmacologic stress testing associated with the index hospitalization; or resting ECG","text_display":" pharmacologic stress testing associated with the index hospitalization; or resting ECG","confidence":1,"confidence_rate":1},{"cnt":[[305,425],[1586,425],[1586,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1281,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9aee7e1e7e854cb48ec15ecb699f4822","type":"text","conversion_output":true,"text":"findings consistent with ischemia occurring with symptoms during the index","text_display":" findings consistent with ischemia occurring with symptoms during the index","confidence":1,"confidence_rate":1},{"cnt":[[305,471],[569,471],[569,518],[305,518]],"region":{"top_left_x":305,"top_left_y":470,"width":265,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36f85365e96c43d594427c6c779a99a6","type":"text","conversion_output":true,"text":"hospitalization.","text_display":" hospitalization.","confidence":1,"confidence_rate":1},{"cnt":[[301,554],[535,554],[535,606],[301,606]],"region":{"top_left_x":300,"top_left_y":554,"width":235,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe7148d38d7b40a28d6dd13efeef8b3f","type":"section_header","conversion_output":false,"children_ids":["d203c44f7b3442d586ab45494cbc9b0b"],"text":"","text_display":""},{"cnt":[[305,559],[531,559],[531,599],[305,599]],"region":{"top_left_x":305,"top_left_y":558,"width":226,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d203c44f7b3442d586ab45494cbc9b0b","type":"text","conversion_output":true,"parent_id":"fe7148d38d7b40a28d6dd13efeef8b3f","text":"9.1.2 Stroke","text_display":"\n\n\\subsection*{9.1.2 Stroke}","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1729,645],[1729,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1425,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"680c9f987c5c45bd887a9565230e1a58","type":"text","conversion_output":true,"text":"9.1.2.1 Stroke: SPRINT will use standard case definitions for both fatal and nonfatal","text_display":"\n9.1.2.1 Stroke: SPRINT will use standard case definitions for both fatal and nonfatal","confidence":0.9931640625,"confidence_rate":0.9999237872426632},{"cnt":[[305,692],[1712,692],[1712,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1408,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db8722112d2b44459a2b0cb727076d02","type":"text","conversion_output":true,"text":"stroke. Stroke will be defined based on all available data, including symptoms and","text_display":" stroke. Stroke will be defined based on all available data, including symptoms and","confidence":1,"confidence_rate":1},{"cnt":[[305,735],[1506,735],[1506,782],[305,782]],"region":{"top_left_x":305,"top_left_y":734,"width":1202,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"542324c6045840ebb1bc7b9a39ac717b","type":"text","conversion_output":true,"text":"signs, imaging of the brain and large vessels, and cardiac testing, e.g.,","text_display":" signs, imaging of the brain and large vessels, and cardiac testing, e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1760,778],[1760,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1455,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b084e33d77e8455e802b330bc84ccb89","type":"text","conversion_output":true,"text":"echocardiography. Adjudicators will use their clinical judgment based on the available","text_display":" echocardiography. Adjudicators will use their clinical judgment based on the available","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1699,821],[1699,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1395,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5a81fde5f834d5697b8a062b3b10ea2","type":"text","conversion_output":true,"text":"evidence to classify each case, and will be guided by pre-specified definitions and","text_display":" evidence to classify each case, and will be guided by pre-specified definitions and","confidence":1,"confidence_rate":1},{"cnt":[[305,866],[1571,866],[1571,913],[305,913]],"region":{"top_left_x":305,"top_left_y":865,"width":1266,"height":49},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24bc855d8e3748a181c369e5ca3ce0c8","type":"text","conversion_output":true,"text":"operational rules. Stroke is GENERALLY defined as neurological deficit of","text_display":" operational rules. Stroke is GENERALLY defined as neurological deficit of","confidence":1,"confidence_rate":1},{"cnt":[[305,911],[1809,911],[1809,956],[305,956]],"region":{"top_left_x":305,"top_left_y":910,"width":1504,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"638b96a378264486b227e4cd66c9ed15","type":"text","conversion_output":true,"text":"cerebrovascular cause that persists beyond 24 hours or is interrupted by death within 24","text_display":" cerebrovascular cause that persists beyond 24 hours or is interrupted by death within 24","confidence":0.99853515625,"confidence_rate":0.9999845694066055},{"cnt":[[305,954],[1594,954],[1594,1003],[305,1003]],"region":{"top_left_x":305,"top_left_y":953,"width":1290,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f8a35f147134145aa797b7b03e8f3e6","type":"text","conversion_output":true,"text":"hours. (World Health Organization, 1978 Cerebrovascular Disorders (Offset","text_display":" hours. (World Health Organization, 1978 Cerebrovascular Disorders (Offset","confidence":1,"confidence_rate":1},{"cnt":[[305,997],[1755,997],[1755,1046],[305,1046]],"region":{"top_left_x":305,"top_left_y":996,"width":1451,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dac4e287cc0d4bc5b663322b6417dce4","type":"text","conversion_output":true,"text":"Publications). Geneva: World Health Organization. ISBN 9241700432. Exclusionary","text_display":" Publications). Geneva: World Health Organization. ISBN 9241700432. Exclusionary","confidence":1,"confidence_rate":1},{"cnt":[[305,1042],[1738,1042],[1738,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1041,"width":1434,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45fdf81c4b6540f2bb016c9091d622de","type":"text","conversion_output":true,"text":"conditions for stroke include major brain trauma, intracranial neoplasm, coma due to","text_display":" conditions for stroke include major brain trauma, intracranial neoplasm, coma due to","confidence":1,"confidence_rate":1},{"cnt":[[305,1087],[1807,1087],[1807,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":1502,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c53f1a6bca63400ca35e08d45fb8dfb3","type":"text","conversion_output":true,"text":"metabolic disorders or disorders of fluid or electrolyte balance, peripheral neuropathy, or","text_display":" metabolic disorders or disorders of fluid or electrolyte balance, peripheral neuropathy, or","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1631,1130],[1631,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1326,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d864dbef470d4bb19084a21c26c5967b","type":"text","conversion_output":true,"text":"central nervous system infections. Stroke will be classified as brain infarction,","text_display":" central nervous system infections. Stroke will be classified as brain infarction,","confidence":1,"confidence_rate":1},{"cnt":[[305,1173],[1729,1173],[1729,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1425,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73d7ee9377374a4288e9c6d3dd487412","type":"text","conversion_output":true,"text":"subarachnoid hemorrhage, intraparenchymal hemorrhage, other hemorrhage, other","text_display":" subarachnoid hemorrhage, intraparenchymal hemorrhage, other hemorrhage, other","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[1815,1216],[1815,1265],[305,1265]],"region":{"top_left_x":305,"top_left_y":1216,"width":1511,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a0c40648aca4396bc8aa1a557fa2cfb","type":"text","conversion_output":true,"text":"type, or unknown type. In SPRINT, brain infarction (ischemic stroke) is defined as a new","text_display":" type, or unknown type. In SPRINT, brain infarction (ischemic stroke) is defined as a new","confidence":1,"confidence_rate":1},{"cnt":[[305,1261],[1721,1261],[1721,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1261,"width":1416,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91b285e718bd4cafbe68347991a31fed","type":"text","conversion_output":true,"text":"lesion detected by computed tomography or magnetic resonance imaging or, in the","text_display":" lesion detected by computed tomography or magnetic resonance imaging or, in the","confidence":1,"confidence_rate":1},{"cnt":[[305,1306],[1790,1306],[1790,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":1485,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58708f615aa142a7aef913ea9433ab05","type":"text","conversion_output":true,"text":"absence of a new lesion ON AVAILABLE IMAGING, clinical findings consistent with the","text_display":" absence of a new lesion ON AVAILABLE IMAGING, clinical findings consistent with the","confidence":1,"confidence_rate":1},{"cnt":[[305,1349],[1781,1349],[1781,1394],[305,1394]],"region":{"top_left_x":305,"top_left_y":1349,"width":1477,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c55fa9c9972a4ef8889fc5e0f1bc8a4d","type":"text","conversion_output":true,"text":"occurrence of stroke that lasted for more than 24 hours (N Engl J Med 2001;345:1444-","text_display":" occurrence of stroke that lasted for more than 24 hours (N Engl J Med 2001;345:1444","confidence":0.9863574286043786,"confidence_rate":0.99985070151121},{"cnt":[[305,1392],[1734,1392],[1734,1442],[305,1442]],"region":{"top_left_x":305,"top_left_y":1392,"width":1429,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4945347254024026a3ba79454da90646","type":"text","conversion_output":true,"text":"51). Brain infarctions will be further sub-typed using the Causative Classification of","text_display":"51). Brain infarctions will be further sub-typed using the Causative Classification of","confidence":0.5034141540527344,"confidence_rate":0.992486150517425},{"cnt":[[305,1437],[1755,1437],[1755,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1437,"width":1451,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dcabf4160984959972985d9e826aedb","type":"text","conversion_output":true,"text":"Stroke system as evident, probable, or possible cases of large artery atherosclerosis,","text_display":" Stroke system as evident, probable, or possible cases of large artery atherosclerosis,","confidence":1,"confidence_rate":1},{"cnt":[[305,1482],[1792,1482],[1792,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1482,"width":1487,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e2027035c1c4c58898029ea4284ae67","type":"text","conversion_output":true,"text":"cardio-aortic embolism, small artery occlusion, other causes, and undetermined causes","text_display":" cardio-aortic embolism, small artery occlusion, other causes, and undetermined causes","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1783,1525],[1783,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1525,"width":1479,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dbcdf7cade3455ca98a2866936e0371","type":"text","conversion_output":true,"text":"(Ay and others, 2007). Strokes following invasive cardiovascular interventions will also","text_display":" (Ay and others, 2007). Strokes following invasive cardiovascular interventions will also","confidence":0.9990234375,"confidence_rate":0.9999894942525209},{"cnt":[[305,1568],[679,1568],[679,1611],[305,1611]],"region":{"top_left_x":305,"top_left_y":1568,"width":374,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"227967bcbab04fbb82e73b4f24180a33","type":"text","conversion_output":true,"text":"be classified as such.","text_display":" be classified as such.","confidence":1,"confidence_rate":1},{"cnt":[[301,1650],[471,1650],[471,1704],[301,1704]],"region":{"top_left_x":300,"top_left_y":1650,"width":171,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd65696f595b4ddbaaa819b040f3fc11","type":"section_header","conversion_output":false,"children_ids":["1864e6bc73a141debae2c8cc6919c315"],"text":"","text_display":""},{"cnt":[[305,1656],[466,1656],[466,1699],[305,1699]],"region":{"top_left_x":305,"top_left_y":1656,"width":162,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1864e6bc73a141debae2c8cc6919c315","type":"text","conversion_output":true,"parent_id":"cd65696f595b4ddbaaa819b040f3fc11","text":"9.1.3 HF","text_display":"\n\n\\subsection*{9.1.3 HF}","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1820,1745],[1820,1794],[305,1794]],"region":{"top_left_x":305,"top_left_y":1744,"width":1515,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7de7302c69f4476b02ca7ed35a16468","type":"text","conversion_output":true,"text":"9.1.3.1 HF: Defined as hospitalization, or emergency department visit requiring treatment","text_display":"\n9.1.3.1 HF: Defined as hospitalization, or emergency department visit requiring treatment","confidence":0.9762101173400879,"confidence_rate":0.9997438899126463},{"cnt":[[305,1790],[1695,1790],[1695,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1789,"width":1391,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53ea62e68dce4b92b653ccf2cc8d9ebd","type":"text","conversion_output":true,"text":"with infusion therapy, for a clinical syndrome that presents with multiple signs and","text_display":" with infusion therapy, for a clinical syndrome that presents with multiple signs and","confidence":1,"confidence_rate":1},{"cnt":[[305,1833],[1772,1833],[1772,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1832,"width":1468,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c8bd3b74e26441dba290ef2ebff51cb","type":"text","conversion_output":true,"text":"symptoms consistent with cardiac decompensation/inadequate cardiac pump function.","text_display":" symptoms consistent with cardiac decompensation/inadequate cardiac pump function.","confidence":1,"confidence_rate":1},{"cnt":[[305,1878],[1803,1878],[1803,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1877,"width":1498,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4a4b4be50f2440e886cd1106399107e","type":"text","conversion_output":true,"text":"Adjudication will use the ARIC study adjudication system (Rosamond and others, 2009).","text_display":" Adjudication will use the ARIC study adjudication system (Rosamond and others, 2009).","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1682,1921],[1682,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1378,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"135ecf04e91e483cae4caf506417a58b","type":"text","conversion_output":true,"text":"The SPRINT HF outcome will include definite or possible acute decompensation,","text_display":" The SPRINT HF outcome will include definite or possible acute decompensation,","confidence":1,"confidence_rate":1},{"cnt":[[305,1964],[1783,1964],[1783,2013],[305,2013]],"region":{"top_left_x":305,"top_left_y":1963,"width":1479,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94520c0e4f0c41f5a54a375e4245a53f","type":"text","conversion_output":true,"text":"including HF with preserved left ventricular ejection fraction as well as HF with reduced","text_display":" including HF with preserved left ventricular ejection fraction as well as HF with reduced","confidence":1,"confidence_rate":1},{"cnt":[[305,2007],[1798,2007],[1798,2056],[305,2056]],"region":{"top_left_x":305,"top_left_y":2006,"width":1494,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b94e366cc4444aa88f2fe3ba10d5e395","type":"text","conversion_output":true,"text":"ejection fraction. HF cases may also be adjudicated as chronic stable HF but this is not","text_display":" ejection fraction. HF cases may also be adjudicated as chronic stable HF but this is not","confidence":1,"confidence_rate":1},{"cnt":[[305,2054],[1639,2054],[1639,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2053,"width":1335,"height":47},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3d0a9771fc745ea9b79d2aa8f19d00e","type":"text","conversion_output":true,"text":"considered a SPRINT outcome. In SPRINT, HF will include a variety of clinical","text_display":" considered a SPRINT outcome. In SPRINT, HF will include a variety of clinical","confidence":1,"confidence_rate":1},{"cnt":[[305,2097],[1674,2097],[1674,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2096,"width":1369,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce2d4bf109cc4f44ab81e33dff56d9ce","type":"text","conversion_output":true,"text":"presentations, including acute or subacute HF as the primary reason for hospital","text_display":" presentations, including acute or subacute HF as the primary reason for hospital","confidence":1,"confidence_rate":1},{"cnt":[[305,2140],[1794,2140],[1794,2187],[305,2187]],"region":{"top_left_x":305,"top_left_y":2139,"width":1489,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"403ee7f63dc14a398911ea506b65bf9d","type":"text","conversion_output":true,"text":"admission or for emergency department visit where HF was diagnosed and intravenous","text_display":" admission or for emergency department visit where HF was diagnosed and intravenous","confidence":1,"confidence_rate":1},{"cnt":[[305,2185],[1695,2185],[1695,2230],[305,2230]],"region":{"top_left_x":305,"top_left_y":2184,"width":1391,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"424f7def5ca24852b90db59fbde84102","type":"text","conversion_output":true,"text":"treatment was given. The identification and classification of HF cases will rely on","text_display":" treatment was given. The identification and classification of HF cases will rely on","confidence":0.96142578125,"confidence_rate":0.9995815991761721},{"cnt":[[305,2228],[1777,2228],[1777,2275],[305,2275]],"region":{"top_left_x":305,"top_left_y":2227,"width":1472,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7d2b84aaea14beba2c547e5a3dd0bd3","type":"text","conversion_output":true,"text":"multiple pieces of key clinical data as well as adjudicators' clinical judgment, guided by","text_display":" multiple pieces of key clinical data as well as adjudicators' clinical judgment, guided by","confidence":1,"confidence_rate":1},{"cnt":[[305,2273],[1766,2273],[1766,2318],[305,2318]],"region":{"top_left_x":305,"top_left_y":2273,"width":1462,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d323727c52754a63b025ee2dba1873d3","type":"text","conversion_output":true,"text":"specific, pre-specified definitions and operational rules. No identification of HF should","text_display":" specific, pre-specified definitions and operational rules. No identification of HF should","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1704,2316],[1704,2361],[305,2361]],"region":{"top_left_x":305,"top_left_y":2316,"width":1399,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b0c12fcf5c3408b9dccead82b03beff","type":"text","conversion_output":true,"text":"rely on a single piece of data such as the presence of dyspnea or of edema, a low","text_display":" rely on a single piece of data such as the presence of dyspnea or of edema, a low","confidence":1,"confidence_rate":1},{"cnt":[[305,2359],[1772,2359],[1772,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1468,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a80db752677b423ab0b41749f7b6b9cd","type":"text","conversion_output":true,"text":"ejection fraction, or an increased brain naturetic peptide (BNP) value. Adjudicators will","text_display":" ejection fraction, or an increased brain naturetic peptide (BNP) value. Adjudicators will","confidence":1,"confidence_rate":1},{"cnt":[[305,2402],[1766,2402],[1766,2451],[305,2451]],"region":{"top_left_x":305,"top_left_y":2401,"width":1462,"height":51},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06b0bd7e16714463b526f44fc367e563","type":"text","conversion_output":true,"text":"use both the data available and clinical judgment to distinguish between \"definite\" and","text_display":" use both the data available and clinical judgment to distinguish between \"definite\" and","confidence":1,"confidence_rate":1},{"cnt":[[305,2447],[1751,2447],[1751,2494],[305,2494]],"region":{"top_left_x":305,"top_left_y":2447,"width":1446,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d18c989cf92f441597cecff85577c6da","type":"text","conversion_output":true,"text":"\"possible\" decompensated HF. \"Definite\" decompensated HF will be assigned when","text_display":" \"possible\" decompensated 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presence of co-morbidity could","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1678,382],[1678,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1373,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73d518803d094f278879b51c115cf87d","type":"text","conversion_output":true,"text":"account for the acute symptoms (chronic obstructive pulmonary disease (COPD)","text_display":" account for the acute symptoms (chronic obstructive pulmonary disease (COPD)","confidence":1,"confidence_rate":1},{"cnt":[[305,430],[778,430],[778,475],[305,475]],"region":{"top_left_x":305,"top_left_y":429,"width":473,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec108355ed2c4ad09bf6a1cf733b6dd5","type":"text","conversion_output":true,"text":"exacerbation, for example).","text_display":" exacerbation, for 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the fluid overload can be purely the consequence","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1777,602],[1777,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1472,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65154e0e766f49bdbb98187c43b5bbd8","type":"text","conversion_output":true,"text":"of fluid retention by the kidney or absence of kidneys. Under these circumstances, the","text_display":" of fluid retention by the kidney or absence of kidneys. Under these circumstances, the","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1665,645],[1665,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1361,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a33ce595d8d74d9d8aa0f430bea5d2f6","type":"text","conversion_output":true,"text":"adjudicators will again use their best judgment, utilizing all available information.","text_display":" adjudicators will again use their best judgment, utilizing all available information.","confidence":1,"confidence_rate":1},{"cnt":[[301,728],[614,728],[614,780],[301,780]],"region":{"top_left_x":300,"top_left_y":728,"width":315,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64ba215825094ce2a2f95a9aa7a909bb","type":"section_header","conversion_output":false,"children_ids":["3c7d269954214114b4d090796285bafb"],"text":"","text_display":""},{"cnt":[[305,735],[608,735],[608,776],[305,776]],"region":{"top_left_x":305,"top_left_y":734,"width":304,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c7d269954214114b4d090796285bafb","type":"text","conversion_output":true,"parent_id":"64ba215825094ce2a2f95a9aa7a909bb","text":"9.1.4 CVD Death","text_display":"\n\n\\subsection*{9.1.4 CVD Death}","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1783,821],[1783,868],[305,868]],"region":{"top_left_x":305,"top_left_y":820,"width":1479,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e1c641600a74acebbd042acc4120b03","type":"text","conversion_output":true,"text":"9.1.4.1 CVD Death: SPRINT will use standard case definitions for classification of CVD","text_display":"\n9.1.4.1 CVD Death: SPRINT will use standard case definitions for classification of CVD","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[305,868],[1639,868],[1639,913],[305,913]],"region":{"top_left_x":305,"top_left_y":867,"width":1335,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b155c0a9689e4939beda97da33519b88","type":"text","conversion_output":true,"text":"death. Definite CVD events will be defined based on temporal relationship to a","text_display":" death. Definite CVD events will be defined based on temporal relationship to a","confidence":1,"confidence_rate":1},{"cnt":[[305,911],[1772,911],[1772,956],[305,956]],"region":{"top_left_x":305,"top_left_y":910,"width":1468,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78855887472a438ba2336a8b539590c8","type":"text","conversion_output":true,"text":"documented event (e.g., hospitalization for MI or for stroke), or postmortem findings of","text_display":" documented event (e.g., hospitalization for MI or for stroke), or postmortem findings of","confidence":0.5849609375,"confidence_rate":0.9945983767936738},{"cnt":[[305,954],[1811,954],[1811,1001],[305,1001]],"region":{"top_left_x":305,"top_left_y":953,"width":1507,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09dd2941cfd84d0697303536e818561e","type":"text","conversion_output":true,"text":"an acute CVD event. Probable coronary heart disease (CHD) death (Luepker, 2003) will","text_display":" an acute CVD event. Probable coronary heart disease (CHD) death (Luepker, 2003) will","confidence":1,"confidence_rate":1},{"cnt":[[305,999],[1794,999],[1794,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":999,"width":1489,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe1a037eb31b4963b0dbd84d39d60863","type":"text","conversion_output":true,"text":"be defined based on autopsy findings consistent with chronic CHD, prior history of CHD","text_display":" be defined based on autopsy findings consistent with chronic CHD, prior history of CHD","confidence":0.99853515625,"confidence_rate":0.999983891144227},{"cnt":[[305,1042],[1695,1042],[1695,1087],[305,1087]],"region":{"top_left_x":305,"top_left_y":1041,"width":1391,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b215b0bfdb94ac09923797c39bb6586","type":"text","conversion_output":true,"text":"or documented symptoms consistent with CHD prior to death, and the absence of","text_display":" or documented symptoms consistent with CHD prior to death, and the absence of","confidence":1,"confidence_rate":1},{"cnt":[[305,1087],[1751,1087],[1751,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":1446,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e1028eead0a49cea09f5b155b2ec66d","type":"text","conversion_output":true,"text":"another likely cause of death. Possible fatal CHD will be adjudicated based on death","text_display":" another likely cause of death. Possible fatal CHD will be adjudicated based on death","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1751,1130],[1751,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1446,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1c47d020d314345938d01aed627e47d","type":"text","conversion_output":true,"text":"certificate information consistent with an underlying CHD cause and no evidence of a","text_display":" certificate information consistent with an underlying CHD cause and no evidence of a","confidence":1,"confidence_rate":1},{"cnt":[[305,1173],[1637,1173],[1637,1220],[305,1220]],"region":{"top_left_x":305,"top_left_y":1173,"width":1333,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3782495acc0a4653a0bcde5c014c2905","type":"text","conversion_output":true,"text":"non-coronary cause. Stroke deaths will be categorized based on the temporal","text_display":" non-coronary cause. Stroke deaths will be categorized based on the temporal","confidence":1,"confidence_rate":1},{"cnt":[[305,1216],[1813,1216],[1813,1263],[305,1263]],"region":{"top_left_x":305,"top_left_y":1216,"width":1509,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33aa0acb37be4759ac74b2c0733c2f74","type":"text","conversion_output":true,"text":"relationship between the stroke event and death, in cases where the underlying cause of","text_display":" relationship between the stroke event and death, in cases where the underlying cause of","confidence":1,"confidence_rate":1},{"cnt":[[305,1263],[1755,1263],[1755,1304],[305,1304]],"region":{"top_left_x":305,"top_left_y":1263,"width":1451,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e44b937629b453b8bcaabc0d0f67276","type":"text","conversion_output":true,"text":"death is attributed to stroke. Proximal stroke death is a death attributed to stroke and","text_display":" death is attributed to stroke. Proximal stroke death is a death attributed to stroke and","confidence":1,"confidence_rate":1},{"cnt":[[305,1306],[1794,1306],[1794,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":1489,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"472b2b899cd24780b5d3c0434f76d810","type":"text","conversion_output":true,"text":"occurring within 30 days of stroke; remote stroke death is underlying cause attributed to","text_display":" occurring within 30 days of stroke; remote stroke death is underlying cause attributed to","confidence":0.99755859375,"confidence_rate":0.9999748004067751},{"cnt":[[305,1349],[1790,1349],[1790,1394],[305,1394]],"region":{"top_left_x":305,"top_left_y":1349,"width":1485,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01faa5534de84420951831fbd3e2735d","type":"text","conversion_output":true,"text":"stroke and more than 30 days from stroke to death. Other forms of CVD death will also","text_display":" stroke and more than 30 days from stroke to death. Other forms of CVD death will also","confidence":1,"confidence_rate":1},{"cnt":[[305,1392],[1699,1392],[1699,1439],[305,1439]],"region":{"top_left_x":305,"top_left_y":1392,"width":1395,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54e2a43c3a3a497bb73b447cdb02f5b1","type":"text","conversion_output":true,"text":"be adjudicated and include ruptured abdominal aortic aneurysm, and documented","text_display":" be adjudicated and include ruptured abdominal aortic aneurysm, and documented","confidence":1,"confidence_rate":1},{"cnt":[[305,1439],[505,1439],[505,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1439,"width":200,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b9e547e43a147889adcd66254fa4c81","type":"text","conversion_output":true,"text":"arrhythmia.","text_display":" arrhythmia.","confidence":1,"confidence_rate":1},{"cnt":[[301,1521],[776,1521],[776,1575],[301,1575]],"region":{"top_left_x":300,"top_left_y":1521,"width":476,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b3ad074c25a45758ca311aa94cf2bb9","type":"section_header","conversion_output":false,"children_ids":["cf415caf10474611874c272642e12a50"],"text":"","text_display":""},{"cnt":[[305,1525],[771,1525],[771,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1525,"width":467,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf415caf10474611874c272642e12a50","type":"text","conversion_output":true,"parent_id":"5b3ad074c25a45758ca311aa94cf2bb9","text":"9.2 Secondary Outcomes","text_display":"\n\n\\subsection*{9.2 Secondary Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1764,1611],[1764,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1459,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ee6c9d049d34251bb118032522f8a30","type":"text","conversion_output":true,"text":"In addition to the primary outcome, SPRINT will assess additional clinical outcomes in","text_display":"\n\nIn addition to the primary outcome, SPRINT will assess additional clinical outcomes in","confidence":1,"confidence_rate":1},{"cnt":[[305,1659],[1777,1659],[1777,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1658,"width":1472,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e55b665d32394923bed274c6ac6c6b20","type":"text","conversion_output":true,"text":"order to more fully evaluate the relative effects of treating to a SBP goal lower than the","text_display":" order to more fully evaluate the relative effects of treating to a SBP goal lower than the","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[305,1702],[1798,1702],[1798,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1701,"width":1494,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02d0190f707844b3914e0e16344f7c0d","type":"text","conversion_output":true,"text":"currently recommended goal. In order to do so, data will be collected on secondary and","text_display":" currently recommended goal. In order to do so, data will be collected on secondary and","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1738,1745],[1738,1792],[305,1792]],"region":{"top_left_x":305,"top_left_y":1744,"width":1434,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa45cc4a9a524092882ccadd0dcf364a","type":"text","conversion_output":true,"text":"other trial outcomes. Main secondary outcomes are included in the analysis plan in","text_display":" other trial outcomes. Main secondary outcomes are included in the analysis plan in","confidence":1,"confidence_rate":1},{"cnt":[[305,1788],[518,1788],[518,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1787,"width":213,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2caa58a6db44f64b924a279f46a8ef3","type":"text","conversion_output":true,"text":"Chapter 10.","text_display":" Chapter 10.","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[305,1876],[1723,1876],[1723,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1875,"width":1419,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09132b19f9894f07ba4b92e9cf4d367b","type":"text","conversion_output":true,"text":"9.2.1 Main secondary cardiovascular composite outcome: The main secondary","text_display":"\n9.2.1 Main secondary cardiovascular composite outcome: The main secondary","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1665,1921],[1665,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1361,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fedda09f459497e9a04993f9e063775","type":"text","conversion_output":true,"text":"composite outcome of SPRINT is comprised of the first occurrence of any of the","text_display":" composite outcome of SPRINT is comprised of the first occurrence of any of the","confidence":0.9150390625,"confidence_rate":0.9989308307238811},{"cnt":[[305,1965],[1742,1963],[1742,2011],[305,2013]],"region":{"top_left_x":305,"top_left_y":1963,"width":1438,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b44ad4bb4c94ea4b1a21dc05409518b","type":"text","conversion_output":true,"text":"components of the primary outcome and all cause mortality. A major and analogous","text_display":" components of the primary outcome and all cause mortality. A major and analogous","confidence":1,"confidence_rate":1},{"cnt":[[305,2011],[1790,2011],[1790,2056],[305,2056]],"region":{"top_left_x":305,"top_left_y":2010,"width":1485,"height":47},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b055de9a5f9a46f590f0ef7cef2d5ead","type":"text","conversion_output":true,"text":"secondary outcome of CVD-free survival, defined as survival without any of the primary","text_display":" secondary outcome of CVD-free survival, defined as survival without any of the primary","confidence":1,"confidence_rate":1},{"cnt":[[305,2054],[1813,2054],[1813,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2053,"width":1509,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"102175e83b8144cd948303c8379c7695","type":"text","conversion_output":true,"text":"or secondary CVD outcomes, will also be examined because of the significant proportion","text_display":" or secondary CVD outcomes, will also be examined because of the significant proportion","confidence":1,"confidence_rate":1},{"cnt":[[305,2097],[1740,2097],[1740,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2096,"width":1436,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8c2ade2f8064346bdd9724785f22c94","type":"text","conversion_output":true,"text":"of elderly in the trial and the public health importance of the issue of CVD in that age","text_display":" of elderly in the trial and the public health importance of the issue of CVD in that age","confidence":1,"confidence_rate":1},{"cnt":[[305,2140],[1661,2140],[1661,2187],[305,2187]],"region":{"top_left_x":305,"top_left_y":2139,"width":1356,"height":49},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b3d557a53d645a3a4ea792b8e266025","type":"text","conversion_output":true,"text":"group. All cause mortality and components of the primary outcome will also be","text_display":" group. All cause mortality and components of the primary outcome will also be","confidence":1,"confidence_rate":1},{"cnt":[[305,2185],[492,2185],[492,2224],[305,2224]],"region":{"top_left_x":305,"top_left_y":2184,"width":187,"height":40},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24236ae16dcb4a38aea07a1efeb61d32","type":"text","conversion_output":true,"text":"examined.","text_display":" examined.","confidence":1,"confidence_rate":1},{"cnt":[[305,2271],[1796,2271],[1796,2318],[305,2318]],"region":{"top_left_x":305,"top_left_y":2270,"width":1492,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f8fbe0165234bf38262ebe9c5fda9a5","type":"text","conversion_output":true,"text":"9.2.2 Main secondary renal outcome: The main secondary renal outcome of SPRINT","text_display":"\n9.2.2 Main secondary renal outcome: The main secondary renal outcome of SPRINT","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1747,2316],[1747,2361],[305,2361]],"region":{"top_left_x":305,"top_left_y":2316,"width":1442,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c851853f8090442ea4b5acd1a4315d1b","type":"text","conversion_output":true,"text":"will be the composite of a \\(50 \\%\\) decrease in eGFR or development of ESRD requiring","text_display":" will be the composite of a \\(50 \\%\\) decrease in eGFR or development of ESRD requiring","confidence":0.6399993896484375,"confidence_rate":0.9949413829317706},{"cnt":[[305,2359],[1764,2359],[1764,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1459,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07e7f526762f4a01bf4574d4bb2e6468","type":"text","conversion_output":true,"text":"chronic dialysis or kidney transplantation. This outcome applies to the CKD subgroup","text_display":" chronic dialysis or kidney transplantation. This outcome applies to the CKD subgroup","confidence":1,"confidence_rate":1},{"cnt":[[305,2406],[397,2406],[397,2451],[305,2451]],"region":{"top_left_x":305,"top_left_y":2406,"width":93,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c242c73940742e78c361d6388eb7b24","type":"text","conversion_output":true,"text":"only.","text_display":" only.","confidence":1,"confidence_rate":1},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"998ad653b9314581b68f1759658db3ec","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c226a56baa24382a32dcbb1722cd5ab","type":"page_info","conversion_output":false,"text":"57","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2636],[1815,2636],[1815,2675],[1521,2675]],"region":{"top_left_x":1521,"top_left_y":2636,"width":295,"height":39},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d561012f851d4b79a956d558a638ee61","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-060","page":60,"lines":[{"cnt":[[305,249],[1815,249],[1815,296],[305,296]],"region":{"top_left_x":305,"top_left_y":249,"width":1511,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aca26e8e7e804a289fdbdb485d0ad58b","type":"text","conversion_output":true,"text":"9.2.3 Main secondary cognitive outcomes: SPRINT MIND will evaluate the incidence","text_display":"\n9.2.3 Main secondary cognitive outcomes: SPRINT MIND will evaluate the incidence","confidence":1,"confidence_rate":1},{"cnt":[[305,294],[1798,294],[1798,342],[305,342]],"region":{"top_left_x":305,"top_left_y":294,"width":1494,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"401c5e27035e4857a3ccbd959ac3b948","type":"text","conversion_output":true,"text":"of all-cause dementia as adjudicated by an expert panel as the most important outcome","text_display":" of all-cause dementia as adjudicated by an expert panel as the most important outcome","confidence":1,"confidence_rate":1},{"cnt":[[305,339],[1815,339],[1815,385],[305,385]],"region":{"top_left_x":305,"top_left_y":339,"width":1511,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b049ce1973944d3bab1eb0845e4f3740","type":"text","conversion_output":true,"text":"for the MIND study. The second most important outcome is cognitive impairment among","text_display":" for the MIND study. The second most important outcome is cognitive impairment among","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[305,382],[1708,382],[1708,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1404,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a70af9f9e9f24c92bc9193c8906c4782","type":"text","conversion_output":true,"text":"the Extensive Cognitive Assessment Battery participants will be tested with the full","text_display":" the Extensive Cognitive Assessment Battery participants will be tested with the full","confidence":1,"confidence_rate":1},{"cnt":[[305,425],[1695,425],[1695,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1391,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d277f1242514888b94d2b6194217f84","type":"text","conversion_output":true,"text":"assessment battery (6.4.1.3 and 6.6.2). Each test score from the full assessment","text_display":" assessment battery (6.4.1.3 and 6.6.2). Each test score from the full assessment","confidence":1,"confidence_rate":1},{"cnt":[[305,468],[1772,468],[1772,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1468,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95530bf9abdb401bb54db29eba3446ec","type":"text","conversion_output":true,"text":"battery will be classified as indicating \"impairment (1)\" or \"no impairment ( 0 )\" based on","text_display":" battery will be classified as indicating \"impairment (1)\" or \"no impairment ( 0 )\" based on","confidence":0.6451528469808636,"confidence_rate":0.9955828348191588},{"cnt":[[305,516],[1734,516],[1734,561],[305,561]],"region":{"top_left_x":305,"top_left_y":515,"width":1429,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef537a84c2474c0ba792cd6a4f42d074","type":"text","conversion_output":true,"text":"norms. A sum of impairment scores will be calculated indicating the total number of","text_display":" norms. A sum of impairment scores will be calculated indicating the total number of","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[305,559],[1665,559],[1665,606],[305,606]],"region":{"top_left_x":305,"top_left_y":558,"width":1361,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abebd9067d684c0a84fb3fce6452d278","type":"text","conversion_output":true,"text":"impairments. Detailed definitions of these outcomes are contained in chapter 6.","text_display":" impairments. Detailed definitions of these outcomes are contained in chapter 6.","confidence":0.96875,"confidence_rate":0.9996175587117953},{"cnt":[[305,645],[1674,645],[1674,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1369,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"961763f76933475e9f4be3c51c9c8de2","type":"text","conversion_output":true,"text":"9.2.4 Additional secondary outcomes: In addition to the secondary outcomes","text_display":"\n9.2.4 Additional secondary outcomes: In addition to the secondary outcomes","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[1803,692],[1803,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1498,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a9e0ccf9ea84c0eb76bf655ab083c9a","type":"text","conversion_output":true,"text":"specified in Chapter 10, other outcomes will also be examined separately and combined","text_display":" specified in Chapter 10, other outcomes will also be examined separately and combined","confidence":1,"confidence_rate":1},{"cnt":[[305,735],[1583,735],[1583,782],[305,782]],"region":{"top_left_x":305,"top_left_y":734,"width":1279,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"549dd609027043268aedeb9f49f51abe","type":"text","conversion_output":true,"text":"with other outcomes in composites (e.g., CVD-free survival defined above):","text_display":" with other outcomes in composites (e.g., CVD-free survival defined above):","confidence":1,"confidence_rate":1},{"cnt":[[305,780],[1682,780],[1682,827],[305,827]],"region":{"top_left_x":305,"top_left_y":779,"width":1378,"height":49},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a36e87e74e4f44fba5b5031bc3eade0f","type":"text","conversion_output":true,"text":"- Peripheral arterial disease, including carotid and peripheral revascularization,","text_display":"\n- Peripheral arterial disease, including carotid and peripheral revascularization,","confidence":1,"confidence_rate":1},{"cnt":[[370,825],[1669,825],[1669,870],[370,870]],"region":{"top_left_x":369,"top_left_y":825,"width":1301,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7605b03ed8f04762a2ffa5b2e7dd5576","type":"text","conversion_output":true,"text":"abdominal aortic aneurysm repair, and other objectively defined PAD events","text_display":" abdominal aortic aneurysm repair, and other objectively defined PAD events","confidence":1,"confidence_rate":1},{"cnt":[[305,872],[834,872],[834,917],[305,917]],"region":{"top_left_x":305,"top_left_y":872,"width":529,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed86b84c4cf346c7a1aeb6519a416f78","type":"text","conversion_output":true,"text":"- Coronary revascularization","text_display":"\n- Coronary revascularization","confidence":1,"confidence_rate":1},{"cnt":[[305,915],[1706,915],[1706,965],[305,965]],"region":{"top_left_x":305,"top_left_y":915,"width":1401,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b06d2818e6841a7b28c242cc52ea22c","type":"text","conversion_output":true,"text":"- Transient Ischemic Attack (TIA): TIA in SPRINT will be defined as one or more","text_display":"\n- Transient Ischemic Attack (TIA): TIA in SPRINT will be defined as one or more","confidence":1,"confidence_rate":1},{"cnt":[[370,962],[1755,962],[1755,1008],[370,1008]],"region":{"top_left_x":369,"top_left_y":962,"width":1387,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f05be42727874e87b1773a908e6327a3","type":"text","conversion_output":true,"text":"transient episodes of the sudden onset of a focal neurological deficit, no lesion on","text_display":" transient episodes of the sudden onset of a focal neurological deficit, no lesion on","confidence":1,"confidence_rate":1},{"cnt":[[370,1005],[1772,1005],[1772,1053],[370,1053]],"region":{"top_left_x":369,"top_left_y":1005,"width":1404,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47a51a9b7df94b05992d7645b032ffca","type":"text","conversion_output":true,"text":"brain imaging consistent with the deficit, and no signs or symptoms consistent with","text_display":" brain imaging consistent with the deficit, and no signs or symptoms consistent with","confidence":1,"confidence_rate":1},{"cnt":[[370,1048],[1214,1048],[1214,1096],[370,1096]],"region":{"top_left_x":369,"top_left_y":1048,"width":845,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a4e39b766fd41d99074d36c37dd8714","type":"text","conversion_output":true,"text":"seizures, migraine, or other non-vascular causes.","text_display":" seizures, migraine, or other non-vascular causes.","confidence":1,"confidence_rate":1},{"cnt":[[305,1096],[1740,1096],[1740,1143],[305,1143]],"region":{"top_left_x":305,"top_left_y":1095,"width":1436,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2fcf032c544459580add6bbafc9eb11","type":"text","conversion_output":true,"text":"- ECG diagnosed Left Ventricular Hypertrophy (LVH): ECG-diagnosed LVH will be","text_display":"\n- ECG diagnosed Left Ventricular Hypertrophy (LVH): ECG-diagnosed LVH will be","confidence":1,"confidence_rate":1},{"cnt":[[370,1141],[1725,1141],[1725,1188],[370,1188]],"region":{"top_left_x":369,"top_left_y":1140,"width":1357,"height":49},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32c85b4bcbe747338c194d0d605de649","type":"text","conversion_output":true,"text":"defined primarily using the sex-specific Cornell voltage criteria. Other ECG-LVH","text_display":" defined primarily using the sex-specific Cornell voltage criteria. Other ECG-LVH","confidence":1,"confidence_rate":1},{"cnt":[[370,1182],[1742,1182],[1742,1231],[370,1231]],"region":{"top_left_x":369,"top_left_y":1181,"width":1374,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"721a669c30fb4dfa833d08307e0ceddf","type":"text","conversion_output":true,"text":"criteria mentioned in the American Heart Association (AHA)/American College of","text_display":" criteria mentioned in the American Heart Association (AHA)/American College of","confidence":1,"confidence_rate":1},{"cnt":[[370,1229],[1725,1229],[1725,1274],[370,1274]],"region":{"top_left_x":369,"top_left_y":1228,"width":1357,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05f2065195c34ab9ad24b0df7be08a20","type":"text","conversion_output":true,"text":"Cardiology (ACC) statement on ECG changes associated with cardiac chamber","text_display":" Cardiology (ACC) statement on ECG changes associated with cardiac chamber","confidence":1,"confidence_rate":1},{"cnt":[[370,1272],[1467,1272],[1467,1317],[370,1317]],"region":{"top_left_x":369,"top_left_y":1271,"width":1099,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ef581fc212047a0a5db558c536ad025","type":"text","conversion_output":true,"text":"hypertrophy (Hancock and others, 2009) will be also considered.","text_display":" hypertrophy (Hancock and others, 2009) will be also considered.","confidence":1,"confidence_rate":1},{"cnt":[[305,1319],[1807,1319],[1807,1364],[305,1364]],"region":{"top_left_x":305,"top_left_y":1319,"width":1502,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2943433daa5245ff8738ef96634e5c0e","type":"text","conversion_output":true,"text":"- Atrial fibrillation or flutter: In SPRINT, atrial fibrillation/flutter will be primarily detected","text_display":"\n- Atrial fibrillation or flutter: In SPRINT, atrial fibrillation/flutter will be primarily detected","confidence":1,"confidence_rate":1},{"cnt":[[370,1362],[1729,1362],[1729,1409],[370,1409]],"region":{"top_left_x":369,"top_left_y":1362,"width":1361,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86020561a54d4e10a4247456b26ee81d","type":"text","conversion_output":true,"text":"from the scheduled study ECGs using Minnesota ECG classification (Minnesota","text_display":" from the scheduled study ECGs using Minnesota ECG classification (Minnesota","confidence":1,"confidence_rate":1},{"cnt":[[370,1405],[1772,1405],[1772,1452],[370,1452]],"region":{"top_left_x":369,"top_left_y":1405,"width":1404,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd7eded6040743b1bb71220e348e1fb9","type":"text","conversion_output":true,"text":"code 8.3). Other sources of detection include hospital discharge ICD code (ICD-10","text_display":" code 8.3). Other sources of detection include hospital discharge ICD code (ICD-10","confidence":1,"confidence_rate":1},{"cnt":[[370,1448],[1171,1448],[1171,1497],[370,1497]],"region":{"top_left_x":369,"top_left_y":1448,"width":802,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"518963a5e734476d97797ceaed29b7b0","type":"text","conversion_output":true,"text":"code 148 or ICD-9 code 427.3) and self-report.","text_display":" code 148 or ICD-9 code 427.3) and self-report.","confidence":1,"confidence_rate":1},{"cnt":[[305,1495],[746,1495],[746,1538],[305,1538]],"region":{"top_left_x":305,"top_left_y":1495,"width":441,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37eaa770c28b414285be20f5b67a510d","type":"text","conversion_output":true,"text":"- Other renal outcomes","text_display":"\n- Other renal outcomes","confidence":1,"confidence_rate":1},{"cnt":[[432,1538],[1811,1538],[1811,1583],[432,1583]],"region":{"top_left_x":431,"top_left_y":1538,"width":1381,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8f11e5ff72d499a8733954caf28f824","type":"text","conversion_output":true,"text":"- Incident CKD, defined as a \\(>30 \\%\\) decrease in eGFR and an end value of <60","text_display":"\n- Incident CKD, defined as a \\(>30 \\%\\) decrease in eGFR and an end value of <60","confidence":0.8013742743059993,"confidence_rate":0.9973033111249003},{"cnt":[[494,1577],[1772,1577],[1772,1631],[494,1631]],"region":{"top_left_x":494,"top_left_y":1576,"width":1279,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dc176ced55342fab34763297ecc2e6c","type":"text","conversion_output":true,"text":"\\(ml / min / 1.73 M ^{2}\\). This outcome applies only to the non-CKD subgroup. This","text_display":" \\(ml / min / 1.73 M ^{2}\\). This outcome applies only to the non-CKD subgroup. 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This outcome","text_display":" (ACR) ratio from a value \\(<10 mg / g\\) to a value of \\(>10 mg / g\\). This outcome","confidence":1,"confidence_rate":1},{"cnt":[[494,1805],[1725,1805],[1725,1850],[494,1850]],"region":{"top_left_x":494,"top_left_y":1804,"width":1232,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6181682095444d41a058cd13a2f6eb8c","type":"text","conversion_output":true,"text":"applies to CKD and non-CKD subjects. This increase in ACR requires a","text_display":" applies to CKD and non-CKD subjects. 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The primary objective is to determine whether the","text_display":" been guided by power computations. The primary objective is to determine whether the","confidence":1,"confidence_rate":1},{"cnt":[[305,494],[1674,494],[1674,539],[305,539]],"region":{"top_left_x":305,"top_left_y":494,"width":1369,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d05aaee61a24d999e57f0153f993e29","type":"text","conversion_output":true,"text":"intensive BP treatment strategy will, when compared to a standard BP treatment","text_display":" intensive BP treatment strategy will, when compared to a standard BP treatment","confidence":1,"confidence_rate":1},{"cnt":[[305,537],[1768,537],[1768,587],[305,587]],"region":{"top_left_x":305,"top_left_y":537,"width":1464,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37a221991b4d4d9a9b13419f10fb5ddb","type":"text","conversion_output":true,"text":"strategy, reduce the incidence of serious cardiovascular events, defined as MI, stroke,","text_display":" strategy, reduce the incidence of serious cardiovascular events, defined as MI, stroke,","confidence":0.8460738658905029,"confidence_rate":0.9981848167104277},{"cnt":[[305,580],[1772,580],[1772,629],[305,629]],"region":{"top_left_x":305,"top_left_y":580,"width":1468,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8182def0a0b1486fb0801ab087a072cf","type":"text","conversion_output":true,"text":"heart failure, non-Ml acute coronary syndrome or other cardiovascular death. This will","text_display":" heart failure, non-Ml acute coronary syndrome or other cardiovascular death. This will","confidence":0.515625,"confidence_rate":0.992747574795959},{"cnt":[[305,627],[930,627],[930,672],[305,672]],"region":{"top_left_x":305,"top_left_y":627,"width":626,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a44477a21d6d4d82a32d332e77274644","type":"text","conversion_output":true,"text":"be tested in all SPRINT participants.","text_display":" be tested in all SPRINT participants.","confidence":1,"confidence_rate":1},{"cnt":[[305,713],[1689,713],[1689,763],[305,763]],"region":{"top_left_x":305,"top_left_y":713,"width":1384,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23924635fb93488384161cea0da6dc1f","type":"text","conversion_output":true,"text":"The key secondary objectives are to determine whether the intensive BP strategy","text_display":"\n\nThe key secondary objectives are to determine whether the intensive BP strategy","confidence":1,"confidence_rate":1},{"cnt":[[305,761],[741,761],[741,801],[305,801]],"region":{"top_left_x":305,"top_left_y":760,"width":437,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42b0d864f4104f7897e5489425178cec","type":"text","conversion_output":true,"text":"reduces the incidence of:","text_display":" reduces the incidence of:","confidence":1,"confidence_rate":1},{"cnt":[[434,804],[741,804],[741,849],[434,849]],"region":{"top_left_x":433,"top_left_y":803,"width":309,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a5fdabebd19481b9d839f0b310a27e5","type":"text","conversion_output":true,"text":"1) total mortality,","text_display":"\n1) total mortality,","confidence":1,"confidence_rate":1},{"cnt":[[430,846],[846,846],[846,892],[430,892]],"region":{"top_left_x":429,"top_left_y":846,"width":418,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9cf885bc5934f899a042368bcd8a451","type":"text","conversion_output":true,"text":"2) progression of CKD,","text_display":"\n2) progression of CKD,","confidence":0.9487795829772949,"confidence_rate":0.9980545330361029},{"cnt":[[432,889],[831,889],[831,937],[432,937]],"region":{"top_left_x":431,"top_left_y":889,"width":401,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99664e77a10944c9a110d5b8ffb7d12b","type":"text","conversion_output":true,"text":"3) probable dementia,","text_display":"\n3) probable dementia,","confidence":0.82470703125,"confidence_rate":0.9926148258209074},{"cnt":[[430,935],[939,935],[939,982],[430,982]],"region":{"top_left_x":429,"top_left_y":934,"width":510,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4612c1acf5844a99b992bacc75360eef","type":"text","conversion_output":true,"text":"4) cognitive impairment, and","text_display":"\n4) cognitive impairment, and","confidence":1,"confidence_rate":1},{"cnt":[[430,975],[1141,975],[1141,1025],[430,1025]],"region":{"top_left_x":429,"top_left_y":975,"width":712,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"963556b898f5444f9ae1e231331bc308","type":"text","conversion_output":true,"text":"5) white matter lesions detected by MRI.","text_display":"\n5) white matter lesions detected by MRI.","confidence":1,"confidence_rate":1},{"cnt":[[305,1023],[1611,1023],[1611,1068],[305,1068]],"region":{"top_left_x":305,"top_left_y":1022,"width":1307,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7348f3f5b2dd48ffb98121047a0e3a9a","type":"text","conversion_output":true,"text":"The primary analysis of each of these objectives will be in different groups of","text_display":"\n\nThe primary analysis of each of these objectives will be in different groups of","confidence":1,"confidence_rate":1},{"cnt":[[305,1066],[1785,1066],[1785,1111],[305,1111]],"region":{"top_left_x":305,"top_left_y":1065,"width":1481,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ba7f7ffd19140bda0b10cae4c29528c","type":"text","conversion_output":true,"text":"participants. The analysis plan to address the primary and each secondary objective is","text_display":" participants. The analysis plan to address the primary and each secondary objective is","confidence":1,"confidence_rate":1},{"cnt":[[305,1109],[1607,1109],[1607,1158],[305,1158]],"region":{"top_left_x":305,"top_left_y":1108,"width":1303,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c2e8604ab204992b10f47b6962fd70c","type":"text","conversion_output":true,"text":"described below, followed by estimates of the required sample size for each.","text_display":" described below, followed by estimates of the required sample size for each.","confidence":1,"confidence_rate":1},{"cnt":[[301,1190],[655,1190],[655,1250],[301,1250]],"region":{"top_left_x":300,"top_left_y":1190,"width":356,"height":61},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5790dbe64ac74df798185b279c810782","type":"section_header","conversion_output":false,"children_ids":["2e68ea97f76e4a58bf053f3b35ef6aa1"],"text":"","text_display":""},{"cnt":[[309,1195],[651,1195],[651,1244],[309,1244]],"region":{"top_left_x":309,"top_left_y":1194,"width":342,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e68ea97f76e4a58bf053f3b35ef6aa1","type":"text","conversion_output":true,"parent_id":"5790dbe64ac74df798185b279c810782","text":"10.1 Analysis Plan","text_display":"\n\n\\subsection*{10.1 Analysis Plan}","confidence":1,"confidence_rate":1},{"cnt":[[305,1285],[1747,1285],[1747,1332],[305,1332]],"region":{"top_left_x":305,"top_left_y":1284,"width":1442,"height":49},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f559d06774df4ec194e0bbc8ab28c788","type":"text","conversion_output":true,"text":"This section describes some of the key pre-specified analyses directed at the study's","text_display":"\n\nThis section describes some of the key pre-specified analyses directed at the study's","confidence":1,"confidence_rate":1},{"cnt":[[305,1328],[1794,1328],[1794,1377],[305,1377]],"region":{"top_left_x":305,"top_left_y":1327,"width":1489,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d31858168d5b49248b1e002bb82a2a40","type":"text","conversion_output":true,"text":"primary and key secondary objectives. 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Many other outcomes and measurements, such","confidence":1,"confidence_rate":1},{"cnt":[[305,1375],[1751,1375],[1751,1420],[305,1420]],"region":{"top_left_x":305,"top_left_y":1375,"width":1446,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00c5093af71741b7bbc6425e7a0cf246","type":"text","conversion_output":true,"text":"as blood pressure, adverse event experiences, health related quality of life, cost, and","text_display":" as blood pressure, adverse event experiences, health related quality of life, cost, and","confidence":1,"confidence_rate":1},{"cnt":[[305,1418],[1678,1418],[1678,1463],[305,1463]],"region":{"top_left_x":305,"top_left_y":1417,"width":1373,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a71d2f3c4fe404a83c89fca8b0fb09c","type":"text","conversion_output":true,"text":"results of assays performed on blood and urine specimens will also be analyzed.","text_display":" results of assays performed on blood and urine specimens will also be analyzed.","confidence":1,"confidence_rate":1},{"cnt":[[301,1497],[1605,1497],[1605,1558],[301,1558]],"region":{"top_left_x":300,"top_left_y":1497,"width":1305,"height":61},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1139d7015d4416f9778da4f6daeac6b","type":"section_header","conversion_output":false,"children_ids":["bfdbce43499146ee8fd07098728b29ac"],"text":"","text_display":""},{"cnt":[[309,1504],[1601,1504],[1601,1553],[309,1553]],"region":{"top_left_x":309,"top_left_y":1503,"width":1292,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfdbce43499146ee8fd07098728b29ac","type":"text","conversion_output":true,"parent_id":"b1139d7015d4416f9778da4f6daeac6b","text":"10.1.1 Analysis of the Primary Outcome in all Randomized Participants","text_display":"\n\n\\subsection*{10.1.1 Analysis of the Primary Outcome in all Randomized Participants}","confidence":1,"confidence_rate":1},{"cnt":[[305,1590],[1764,1590],[1764,1639],[305,1639]],"region":{"top_left_x":305,"top_left_y":1589,"width":1459,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb17cc9d26e04a21bc2c2e43b64119da","type":"text","conversion_output":true,"text":"The primary analysis will apply Cox proportional hazards regression (Cox, 1972) to all","text_display":"\n\nThe primary analysis will apply Cox proportional hazards regression (Cox, 1972) to all","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[305,1637],[1790,1637],[1790,1682],[305,1682]],"region":{"top_left_x":305,"top_left_y":1637,"width":1485,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6017ac5441d84ba881ff50251fd30ebe","type":"text","conversion_output":true,"text":"randomized participants to compare the time from randomization to the first occurrence","text_display":" randomized participants to compare the time from randomization to the first occurrence","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[305,1680],[1803,1680],[1803,1725],[305,1725]],"region":{"top_left_x":305,"top_left_y":1680,"width":1498,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2f6077f87d94295ade76409e8a7fc43","type":"text","conversion_output":true,"text":"of the primary CVD composite endpoint between the randomized BP groups. The model","text_display":" of the primary CVD composite endpoint between the randomized BP groups. The model","confidence":1,"confidence_rate":1},{"cnt":[[305,1723],[1803,1723],[1803,1770],[305,1770]],"region":{"top_left_x":305,"top_left_y":1723,"width":1498,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc5694026d204b37806ffb34514498ab","type":"text","conversion_output":true,"text":"will include an indicator for intervention arm as its sole predictor variable. Clinical site at","text_display":" will include an indicator for intervention arm as its sole predictor variable. 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All randomized participants in these analyses will be grouped","text_display":"to-treat principle. All randomized participants in these analyses will be grouped","confidence":1,"confidence_rate":1},{"cnt":[[305,2118],[1760,2118],[1760,2168],[305,2168]],"region":{"top_left_x":305,"top_left_y":2118,"width":1455,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98c7d0f738a14625b4a2eae4ae85213d","type":"text","conversion_output":true,"text":"according to their intervention assignment at randomization, regardless of adherence.","text_display":" according to their intervention assignment at randomization, regardless of adherence.","confidence":1,"confidence_rate":1},{"cnt":[[301,2200],[1399,2200],[1399,2260],[301,2260]],"region":{"top_left_x":300,"top_left_y":2200,"width":1099,"height":61},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4141a514663a44249abe8ccb019591f7","type":"section_header","conversion_output":false,"children_ids":["eb4713abf8a54c5f99709588a463359d"],"text":"","text_display":""},{"cnt":[[309,2206],[1390,2206],[1390,2254],[309,2254]],"region":{"top_left_x":309,"top_left_y":2206,"width":1082,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb4713abf8a54c5f99709588a463359d","type":"text","conversion_output":true,"parent_id":"4141a514663a44249abe8ccb019591f7","text":"10.1.2 Secondary analyses supporting the primary analysis","text_display":"\n\n\\subsection*{10.1.2 Secondary analyses supporting the primary analysis}","confidence":1,"confidence_rate":1},{"cnt":[[305,2295],[1790,2295],[1790,2342],[305,2342]],"region":{"top_left_x":305,"top_left_y":2294,"width":1485,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55dc35595deb4061bfd3005127cfe82d","type":"text","conversion_output":true,"text":"10.1.2.1 Secondary outcomes. A number of secondary outcomes will be analyzed to","text_display":"\n10.1.2.1 Secondary outcomes. A number of secondary outcomes will be analyzed to","confidence":1,"confidence_rate":1},{"cnt":[[305,2340],[1678,2340],[1678,2387],[305,2387]],"region":{"top_left_x":305,"top_left_y":2339,"width":1373,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7113715dcd7b49d7be9d293c29dfbc54","type":"text","conversion_output":true,"text":"clarify the interpretation of the results of the primary analysis. These will include:","text_display":" clarify the interpretation of the results of the primary analysis. These will include:","confidence":1,"confidence_rate":1},{"cnt":[[370,2385],[849,2385],[849,2430],[370,2430]],"region":{"top_left_x":369,"top_left_y":2384,"width":480,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f4135ae910948ecbafd24862a401b7d","type":"text","conversion_output":true,"text":"a) all myocardial infarction,","text_display":"\na) all myocardial infarction,","confidence":1,"confidence_rate":1},{"cnt":[[370,2428],[604,2428],[604,2473],[370,2473]],"region":{"top_left_x":369,"top_left_y":2427,"width":235,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58438ff5ff1e4f15ad7339a37a5b77ff","type":"text","conversion_output":true,"text":"b) all stroke,","text_display":"\nb) all 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and","confidence":1,"confidence_rate":1},{"cnt":[[370,430],[1727,430],[1727,475],[370,475]],"region":{"top_left_x":369,"top_left_y":429,"width":1359,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91a90090394d42969b8405a0d5e269a8","type":"text","conversion_output":true,"text":"g) a composite of total mortality and the primary composite outcome (i.e. major","text_display":"\ng) a composite of total mortality and the primary composite outcome (i.e. major","confidence":1,"confidence_rate":1},{"cnt":[[434,473],[879,473],[879,518],[434,518]],"region":{"top_left_x":433,"top_left_y":472,"width":446,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4383dc389a24c6b8b8e4f295df01e4d","type":"text","conversion_output":true,"text":"CVD event- free survival).","text_display":" CVD event- free 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These will be reported with \\(95 \\%\\) confidence intervals and nominal p-","text_display":" primary analysis. 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In addition to the analysis of the secondary outcomes","text_display":"\n10.1.2.2 Subgroup analyses. In addition to the analysis of the secondary outcomes","confidence":1,"confidence_rate":1},{"cnt":[[309,868],[1706,868],[1706,913],[309,913]],"region":{"top_left_x":309,"top_left_y":867,"width":1397,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0db13bf4d6494527b1da38d4c51ff847","type":"text","conversion_output":true,"text":"described above, a set of analyses will be reported to explore whether intervention","text_display":" described above, a set of analyses will be reported to explore whether intervention","confidence":1,"confidence_rate":1},{"cnt":[[309,911],[1712,911],[1712,956],[309,956]],"region":{"top_left_x":309,"top_left_y":910,"width":1404,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd20f7780e21451f9cd7b79f189d9c15","type":"text","conversion_output":true,"text":"effects on the primary and confirmatory secondary outcomes are consistent across","text_display":" effects on the primary and confirmatory secondary outcomes are consistent across","confidence":1,"confidence_rate":1},{"cnt":[[309,954],[1076,954],[1076,999],[309,999]],"region":{"top_left_x":309,"top_left_y":953,"width":768,"height":47},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92e4c7c2df39457faecba1a9290e8d91","type":"text","conversion_output":true,"text":"subgroups of interest. These subgroups are:","text_display":" subgroups of interest. These subgroups are:","confidence":1,"confidence_rate":1},{"cnt":[[370,997],[1463,997],[1463,1044],[370,1044]],"region":{"top_left_x":369,"top_left_y":996,"width":1095,"height":49},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50119b1971244feeb2f5ef002c21dc40","type":"text","conversion_output":true,"text":"a) CKD (defined as eGFR < 60 at randomization) vs. non-CKD,","text_display":"\na) CKD (defined as eGFR < 60 at randomization) vs. non-CKD,","confidence":0.9975595474243164,"confidence_rate":0.9999635314809043},{"cnt":[[370,1042],[1523,1042],[1523,1089],[370,1089]],"region":{"top_left_x":369,"top_left_y":1041,"width":1155,"height":49},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"186fc232982744c6a609642781003c7e","type":"text","conversion_output":true,"text":"b) senior vs. non-senior (aged \\(\\geq 75\\) at randomization vs. aged \\(<75\\) ),","text_display":"\nb) senior vs. non-senior (aged \\(\\geq 75\\) at randomization vs. aged \\(<75\\) ),","confidence":0.99365234375,"confidence_rate":0.999918363739053},{"cnt":[[372,1087],[715,1087],[715,1132],[372,1132]],"region":{"top_left_x":371,"top_left_y":1087,"width":345,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f88a915c92b8429b95066397ed26eae8","type":"text","conversion_output":true,"text":"c) male vs. female,","text_display":"\nc) male vs. female,","confidence":1,"confidence_rate":1},{"cnt":[[370,1130],[776,1130],[776,1175],[370,1175]],"region":{"top_left_x":369,"top_left_y":1130,"width":407,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea0ee6b175f8478c94c962d6666ef749","type":"text","conversion_output":true,"text":"d) black vs. non-black,","text_display":"\nd) black vs. non-black,","confidence":1,"confidence_rate":1},{"cnt":[[370,1173],[1811,1173],[1811,1222],[370,1222]],"region":{"top_left_x":369,"top_left_y":1173,"width":1443,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af9bd85f1285486eb4510c308c613802","type":"text","conversion_output":true,"text":"e) with and without a history of CVD at randomization (as defined in Chapter 3), and","text_display":"\ne) with and without a history of CVD at randomization (as defined in Chapter 3), and","confidence":1,"confidence_rate":1},{"cnt":[[370,1216],[1197,1216],[1197,1265],[370,1265]],"region":{"top_left_x":369,"top_left_y":1216,"width":828,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fad64a5170cf42d988812e62ce49c381","type":"text","conversion_output":true,"text":"f) tertiles of systolic blood pressure at baseline.","text_display":"\nf) tertiles of systolic blood pressure at baseline.","confidence":1,"confidence_rate":1},{"cnt":[[309,1306],[1745,1306],[1745,1351],[309,1351]],"region":{"top_left_x":309,"top_left_y":1306,"width":1436,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"689b846017ca464bb4bbdbc8c7bb1ad9","type":"text","conversion_output":true,"text":"The subgroups defined by CKD, age and race are motivated by biologically plausible","text_display":"\n\nThe subgroups defined by CKD, age and race are motivated by biologically plausible","confidence":1,"confidence_rate":1},{"cnt":[[309,1349],[1803,1349],[1803,1394],[309,1394]],"region":{"top_left_x":309,"top_left_y":1349,"width":1494,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d252b6332c784f71923332e325b6053e","type":"text","conversion_output":true,"text":"hypotheses. For each subgroup analysis, a proportional hazards model will be used that","text_display":" hypotheses. For each subgroup analysis, a proportional hazards model will be used that","confidence":1,"confidence_rate":1},{"cnt":[[309,1394],[1775,1394],[1775,1439],[309,1439]],"region":{"top_left_x":309,"top_left_y":1394,"width":1466,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"998d590782fd4df2817f52c1e26c366b","type":"text","conversion_output":true,"text":"is similar to the one described for the primary analysis above, but with additional terms","text_display":" is similar to the one described for the primary analysis above, but with additional terms","confidence":1,"confidence_rate":1},{"cnt":[[309,1437],[1729,1437],[1729,1485],[309,1485]],"region":{"top_left_x":309,"top_left_y":1437,"width":1421,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54fc725d07f549868631949f3836cb39","type":"text","conversion_output":true,"text":"identifying subgroup membership and the intervention by subgroup interaction. The","text_display":" identifying subgroup membership and the intervention by subgroup interaction. The","confidence":1,"confidence_rate":1},{"cnt":[[309,1482],[1811,1482],[1811,1528],[309,1528]],"region":{"top_left_x":309,"top_left_y":1482,"width":1503,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a0f6fc9c81c4e899f4dd07aa83d04f7","type":"text","conversion_output":true,"text":"nominal \\(p\\)-value for the interaction term using a likelihood ratio test will be reported along","text_display":" nominal \\(p\\)-value for the interaction term using a likelihood ratio test will be reported along","confidence":0.7975332736968994,"confidence_rate":0.9977844997859335},{"cnt":[[309,1525],[1751,1525],[1751,1571],[309,1571]],"region":{"top_left_x":309,"top_left_y":1525,"width":1442,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee1a1943e3574133be97895404a155dd","type":"text","conversion_output":true,"text":"with within subgroup estimates of the intervention effect and associated nominal 95\\%","text_display":" with within subgroup estimates of the intervention effect and associated nominal 95\\%","confidence":0.9951171875,"confidence_rate":0.9999450040698964},{"cnt":[[309,1568],[1749,1568],[1749,1616],[309,1616]],"region":{"top_left_x":309,"top_left_y":1568,"width":1440,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8734e8df2f5d4be48241a1e6bb7defc0","type":"text","conversion_output":true,"text":"confidence intervals. We will report the Hommel adjusted p-values for the interaction","text_display":" confidence intervals. We will report the Hommel adjusted p-values for the interaction","confidence":0.82421875,"confidence_rate":0.9978543129401993},{"cnt":[[309,1611],[436,1611],[436,1652],[309,1652]],"region":{"top_left_x":309,"top_left_y":1611,"width":128,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a84ed6d8a5e4b67aa8a0fefbd80916d","type":"text","conversion_output":true,"text":"effects.","text_display":" effects.","confidence":1,"confidence_rate":1},{"cnt":[[305,1697],[1137,1697],[1137,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1697,"width":832,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c489d3fb942f4c8ab61ea705caae1d7b","type":"section_header","conversion_output":false,"children_ids":["aee81d4a24de48e5b40773ecf0314340"],"text":"","text_display":""},{"cnt":[[309,1702],[1132,1702],[1132,1742],[309,1742]],"region":{"top_left_x":309,"top_left_y":1701,"width":824,"height":42},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aee81d4a24de48e5b40773ecf0314340","type":"text","conversion_output":true,"parent_id":"c489d3fb942f4c8ab61ea705caae1d7b","text":"10.1.3 Non-cardiovascular clinical outcomes","text_display":"\n\n\\subsection*{10.1.3 Non-cardiovascular clinical outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[305,1783],[1205,1783],[1205,1835],[305,1835]],"region":{"top_left_x":305,"top_left_y":1783,"width":901,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"905de1adf9b149a6a829fd97b5b959a6","type":"section_header","conversion_output":false,"children_ids":["fe557c79643847b69e68501d991c2e5c"],"text":"","text_display":""},{"cnt":[[309,1788],[1201,1788],[1201,1828],[309,1828]],"region":{"top_left_x":309,"top_left_y":1787,"width":892,"height":42},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe557c79643847b69e68501d991c2e5c","type":"text","conversion_output":true,"parent_id":"905de1adf9b149a6a829fd97b5b959a6","text":"10.1.3.1. Acute vs. chronic effects of intervention","text_display":"\n\n\\subsection*{10.1.3.1. 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In the long term, however, lower SBP may protect these organs from","text_display":" SPRINT. In the long term, however, lower SBP may protect these organs from","confidence":1,"confidence_rate":1},{"cnt":[[309,2007],[1792,2007],[1792,2054],[309,2054]],"region":{"top_left_x":309,"top_left_y":2006,"width":1483,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5564c64fdfda4d79b7594acbf1b6017e","type":"text","conversion_output":true,"text":"hypertension-related damage. We will examine the possibility of acute effects as part of","text_display":" hypertension-related damage. We will examine the possibility of acute effects as part of","confidence":1,"confidence_rate":1},{"cnt":[[309,2054],[1785,2054],[1785,2099],[309,2099]],"region":{"top_left_x":309,"top_left_y":2053,"width":1477,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e79e0203ca94e2d830e7b48b079ff90","type":"text","conversion_output":true,"text":"the data monitoring plan, particularly if differential adverse effects are observed early in","text_display":" the data monitoring plan, particularly if differential adverse effects are observed early in","confidence":1,"confidence_rate":1},{"cnt":[[309,2097],[1790,2097],[1790,2142],[309,2142]],"region":{"top_left_x":309,"top_left_y":2096,"width":1481,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7233e06b15cc45e287d399695bfc7f15","type":"text","conversion_output":true,"text":"the trial; we also will examine the possibility of acute effects as part of the data analysis","text_display":" the trial; we also will examine the possibility of acute effects as part of the data analysis","confidence":1,"confidence_rate":1},{"cnt":[[309,2140],[672,2140],[672,2181],[309,2181]],"region":{"top_left_x":309,"top_left_y":2139,"width":364,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28dee7fee6d64a4eb58302156ce1a9dc","type":"text","conversion_output":true,"text":"at the end of the trial.","text_display":" at the end of the trial.","confidence":1,"confidence_rate":1},{"cnt":[[305,2221],[763,2221],[763,2271],[305,2271]],"region":{"top_left_x":305,"top_left_y":2221,"width":458,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a01e27b5b4fd4dfb911692c20abe9030","type":"section_header","conversion_output":false,"children_ids":["3aea0f5cd05449f09e7ff9c77368794d"],"text":"","text_display":""},{"cnt":[[309,2226],[758,2226],[758,2267],[309,2267]],"region":{"top_left_x":309,"top_left_y":2225,"width":450,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3aea0f5cd05449f09e7ff9c77368794d","type":"text","conversion_output":true,"parent_id":"a01e27b5b4fd4dfb911692c20abe9030","text":"10.1.3.2 Renal outcomes","text_display":"\n\n\\subsection*{10.1.3.2 Renal outcomes}","confidence":0.9990234375,"confidence_rate":0.9999651063356614},{"cnt":[[309,2316],[1807,2316],[1807,2361],[309,2361]],"region":{"top_left_x":309,"top_left_y":2316,"width":1498,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa101223b70345be98c58efb09a3cc81","type":"text","conversion_output":true,"text":"Renal outcomes are of particular importance in SPRINT, both to assess the incidence of","text_display":"\n\nRenal outcomes are of particular importance in SPRINT, both to assess the incidence of","confidence":1,"confidence_rate":1},{"cnt":[[309,2359],[1697,2359],[1697,2408],[309,2408]],"region":{"top_left_x":309,"top_left_y":2358,"width":1389,"height":51},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3881a1f5cb6847faa9a2bf6e45b23c14","type":"text","conversion_output":true,"text":"new kidney disease among participants free of CKD at baseline and to assess the","text_display":" new kidney disease among participants free of CKD at baseline and to assess the","confidence":1,"confidence_rate":1},{"cnt":[[309,2402],[1704,2402],[1704,2451],[309,2451]],"region":{"top_left_x":309,"top_left_y":2401,"width":1395,"height":51},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d162c57eebf4ecb970a3885c8e363a9","type":"text","conversion_output":true,"text":"progression of kidney disease among those with CKD at baseline. Because some","text_display":" progression of kidney disease among those with CKD at baseline. Because some","confidence":1,"confidence_rate":1},{"cnt":[[309,2638],[492,2638],[492,2675],[309,2675]],"region":{"top_left_x":309,"top_left_y":2638,"width":183,"height":37},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cbef50d4a6a451b99197baf0ff4cdda","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9422e61ef38d40c8a6a2a19466e0b966","type":"page_info","conversion_output":false,"text":"60","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994},{"cnt":[[1525,2634],[1815,2634],[1815,2675],[1525,2675]],"region":{"top_left_x":1525,"top_left_y":2633,"width":291,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87d720a893fc4611ae7658191e8724df","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-063","page":63,"lines":[{"cnt":[[305,249],[1781,249],[1781,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1477,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"266aef96945f4fd2963457e01d727d5a","type":"text","conversion_output":true,"text":"outcomes are more interpretable in either people with CKD or without CKD at baseline,","text_display":"\noutcomes are more interpretable in either people with CKD or without CKD at baseline,","confidence":1,"confidence_rate":1},{"cnt":[[305,296],[1201,296],[1201,346],[305,346]],"region":{"top_left_x":305,"top_left_y":296,"width":896,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3c2c7ed09af452eb9857b0c7c3c6a30","type":"text","conversion_output":true,"text":"some analyses will be restricted to these subgroups.","text_display":" some analyses will be restricted to these subgroups.","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1790,382],[1790,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1485,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03a1bd68cf114a3db601dd7a2627ad6c","type":"text","conversion_output":true,"text":"The primary hypothesis for the renal outcomes is whether, in the subgroup with CKD at","text_display":"\n\nThe primary hypothesis for the renal outcomes is whether, in the subgroup with CKD at","confidence":1,"confidence_rate":1},{"cnt":[[305,425],[1714,425],[1714,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1410,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5452b98d16074c48a85e54fdc8c7e030","type":"text","conversion_output":true,"text":"baseline, the rate of a composite of a 50\\% decrease in eGFR or ESRD undergoing","text_display":" baseline, the rate of a composite of a 50\\% decrease in eGFR or ESRD undergoing","confidence":0.98583984375,"confidence_rate":0.9998281910518534},{"cnt":[[305,468],[1792,468],[1792,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1487,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7914af5687ba4d79b6513b2163af049b","type":"text","conversion_output":true,"text":"chronic dialysis or kidney transplantation is lower in the intensive intervention arm. The","text_display":" chronic dialysis or kidney transplantation is lower in the intensive intervention arm. The","confidence":1,"confidence_rate":1},{"cnt":[[305,511],[1738,511],[1738,561],[305,561]],"region":{"top_left_x":305,"top_left_y":511,"width":1434,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f2153f580e24887a7cb78f57faef019","type":"text","conversion_output":true,"text":"decline in eGFR must be seen on two visits at least three months apart. This will be","text_display":" decline in eGFR must be seen on two visits at least three months apart. 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These","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[511,692],[511,733],[305,733]],"region":{"top_left_x":305,"top_left_y":691,"width":207,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5b473a7c74f4933b0c6a023ee0ccc1f","type":"text","conversion_output":true,"text":"will include:","text_display":" will include:","confidence":1,"confidence_rate":1},{"cnt":[[365,731],[1794,728],[1794,782],[365,784]],"region":{"top_left_x":365,"top_left_y":728,"width":1430,"height":57},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1aa55a4a91a4fe98848d42047c2cd12","type":"text","conversion_output":true,"text":"a) incident CKD in the non-CKD subgroup, defined as a \\(30 \\%\\) decline from baseline","text_display":"\na) incident CKD in the non-CKD subgroup, defined as a \\(30 \\%\\) decline from baseline","confidence":1,"confidence_rate":1},{"cnt":[[430,773],[1807,773],[1807,827],[430,827]],"region":{"top_left_x":429,"top_left_y":773,"width":1378,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e456ffae556476ca9aeb9b3b8000ed6","type":"text","conversion_output":true,"text":"eGFR to a value of \\(<60 mL / min / 1.73 m^{2}\\) (observed on two visits at least 3 months","text_display":" eGFR to a value of \\(<60 mL / min / 1.73 m^{2}\\) (observed on two visits at least 3 months","confidence":0.9970715045928955,"confidence_rate":0.9999718004760767},{"cnt":[[430,821],[1714,821],[1714,870],[430,870]],"region":{"top_left_x":429,"top_left_y":820,"width":1286,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50057aa806c14e0db9c677b7982144e9","type":"text","conversion_output":true,"text":"apart. There must be a decrease of at least \\(30 \\%\\) AND the end value of this","text_display":" apart. 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This outcome applies","text_display":" (ACR) ratio from a value \\(<10 mg / g\\) to a value of \\(>10 mg / g\\). This outcome applies","confidence":1,"confidence_rate":1},{"cnt":[[430,1040],[1777,1040],[1777,1089],[430,1089]],"region":{"top_left_x":429,"top_left_y":1039,"width":1348,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8df48a052266427ab28ed4485fc6d80b","type":"text","conversion_output":true,"text":"to CKD and non-CKD subjects. This increase in ACR must be observed at two","text_display":" to CKD and non-CKD subjects. 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The analytical approach will be the same as for the primary CV analysis as","text_display":" subgroups. The analytical approach will be the same as for the primary CV analysis as","confidence":0.99658203125,"confidence_rate":0.9999619582419443},{"cnt":[[305,1306],[1130,1306],[1130,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":826,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8853c5f0cb1143e88aa406cd139ae13c","type":"text","conversion_output":true,"text":"described in 10.1.2.2. The renal subgroups are:","text_display":" described in 10.1.2.2. The renal subgroups are:","confidence":1,"confidence_rate":1},{"cnt":[[370,1349],[1467,1349],[1467,1399],[370,1399]],"region":{"top_left_x":369,"top_left_y":1349,"width":1099,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6339e0a0f7ea4bb5be8460cae0157ee3","type":"text","conversion_output":true,"text":"a) urinary albumin/creatinine ratio ( \\(>300 mg / g\\) and \\(\\leq 300 mg / g\\) ),","text_display":"\na) urinary albumin/creatinine ratio ( \\(>300 mg / g\\) and \\(\\leq 300 mg / g\\) ),","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[370,1392],[776,1392],[776,1442],[370,1442]],"region":{"top_left_x":369,"top_left_y":1392,"width":407,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"211c0c2edc23448e86ef0e25236cf705","type":"text","conversion_output":true,"text":"b) black vs. non-black,","text_display":"\nb) black vs. non-black,","confidence":1,"confidence_rate":1},{"cnt":[[370,1435],[1528,1435],[1528,1485],[370,1485]],"region":{"top_left_x":369,"top_left_y":1435,"width":1159,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"caebae3b7ff7405db747d5e611a81585","type":"text","conversion_output":true,"text":"c) senior vs. non-senior (aged \\(75+\\) at randomization vs. aged \\(<75\\) ),","text_display":"\nc) senior vs. non-senior (aged \\(75+\\) at randomization vs. aged \\(<75\\) ),","confidence":0.9848990440368652,"confidence_rate":0.9998049403544731},{"cnt":[[370,1482],[707,1482],[707,1528],[370,1528]],"region":{"top_left_x":369,"top_left_y":1482,"width":338,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8456d7cdc12a4e168fcda6d9ee3b90ec","type":"text","conversion_output":true,"text":"d) male vs female,","text_display":"\nd) male vs female,","confidence":1,"confidence_rate":1},{"cnt":[[370,1525],[784,1525],[784,1573],[370,1573]],"region":{"top_left_x":369,"top_left_y":1525,"width":416,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9e8674b750a4c52b68c45fbaf1c4ef8","type":"text","conversion_output":true,"text":"e) eGFR (median split)","text_display":"\ne) eGFR (median split)","confidence":1,"confidence_rate":1},{"cnt":[[305,1568],[1704,1568],[1704,1618],[305,1618]],"region":{"top_left_x":305,"top_left_y":1568,"width":1399,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5140732618124e1c93d639dc60e1fa05","type":"text","conversion_output":true,"text":"The subgroups defined by albumin/creatinine ratio, age and race are motivated by","text_display":"\n\nThe subgroups defined by albumin/creatinine ratio, age and race are motivated by","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1665,1611],[1665,1661],[305,1661]],"region":{"top_left_x":305,"top_left_y":1611,"width":1361,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9007ef14f60041c98b8fa2b928dbca18","type":"text","conversion_output":true,"text":"biologically plausible hypotheses. The main renal outcome composite is defined","text_display":" biologically plausible hypotheses. The main renal outcome composite is defined","confidence":1,"confidence_rate":1},{"cnt":[[305,1656],[1727,1656],[1727,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1656,"width":1423,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ba9ed785fec431e9cd3f08dbdb65985","type":"text","conversion_output":true,"text":"differently for the CKD and non-CKD strata, so that these will be separate analyses.","text_display":" differently for the CKD and non-CKD strata, so that these will be separate analyses.","confidence":1,"confidence_rate":1},{"cnt":[[303,1738],[1098,1738],[1098,1798],[303,1798]],"region":{"top_left_x":302,"top_left_y":1738,"width":796,"height":61},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ce541edd98148f3a1a1e4c1b0915812","type":"section_header","conversion_output":false,"children_ids":["6e5a63eeb4c342248da995c6f65b585d"],"text":"","text_display":""},{"cnt":[[309,1745],[1094,1745],[1094,1794],[309,1794]],"region":{"top_left_x":309,"top_left_y":1744,"width":785,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e5a63eeb4c342248da995c6f65b585d","type":"text","conversion_output":true,"parent_id":"0ce541edd98148f3a1a1e4c1b0915812","text":"10.1.3.3 Dementia and cognitive outcomes.","text_display":"\n\n\\subsection*{10.1.3.3 Dementia and cognitive outcomes.}","confidence":0.9990236759185791,"confidence_rate":0.9999787654211912},{"cnt":[[305,1830],[1717,1830],[1717,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1830,"width":1412,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa1e7381476a42bd9b28caa040a9c531","type":"text","conversion_output":true,"text":"The primary outcome for SPRINT MIND will be the first identification of adjudicated","text_display":"\n\nThe primary outcome for SPRINT MIND will be the first identification of adjudicated","confidence":1,"confidence_rate":1},{"cnt":[[305,1876],[1691,1876],[1691,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1875,"width":1386,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1571a26d016b4a83a41de653f55f0db6","type":"text","conversion_output":true,"text":"dementia. Cox proportional hazards models (as described above for the SPRINT","text_display":" dementia. Cox proportional hazards models (as described above for the SPRINT","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1691,1921],[1691,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1386,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c49d4e415d1c4966ac2252857fb83758","type":"text","conversion_output":true,"text":"primary outcome) will be used to compare the time from randomization to the first","text_display":" primary outcome) will be used to compare the time from randomization to the first","confidence":1,"confidence_rate":1},{"cnt":[[305,1964],[1691,1964],[1691,2013],[305,2013]],"region":{"top_left_x":305,"top_left_y":1963,"width":1386,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d69bed45be5f4ddd93e3a7a0f0dd3f08","type":"text","conversion_output":true,"text":"identification of dementia between the two treatment arms. All participants will be","text_display":" identification of dementia between the two treatment arms. All participants will be","confidence":1,"confidence_rate":1},{"cnt":[[305,2007],[900,2007],[900,2052],[305,2052]],"region":{"top_left_x":305,"top_left_y":2006,"width":596,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a59db9ade2974ba6a54c8ccc8d903aa5","type":"text","conversion_output":true,"text":"screened for dementia at baseline.","text_display":" screened for dementia at baseline.","confidence":1,"confidence_rate":1},{"cnt":[[309,2093],[1704,2093],[1704,2142],[309,2142]],"region":{"top_left_x":309,"top_left_y":2092,"width":1395,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2034c9147bb14f71b106efdfb0903ad3","type":"text","conversion_output":true,"text":"Secondary analyses. Secondary analyses in the areas of cognitive function, small","text_display":"\n\nSecondary analyses. Secondary analyses in the areas of cognitive function, small","confidence":1,"confidence_rate":1},{"cnt":[[305,2140],[1768,2140],[1768,2187],[305,2187]],"region":{"top_left_x":305,"top_left_y":2139,"width":1464,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0435cda101b047c7bf0b010b8e0e9649","type":"text","conversion_output":true,"text":"vessel ischemic disease (SVID) lesion load, and mild cognitive impairment will also be","text_display":" vessel ischemic disease (SVID) lesion load, and mild cognitive impairment will also be","confidence":1,"confidence_rate":1},{"cnt":[[305,2183],[1029,2183],[1029,2232],[305,2232]],"region":{"top_left_x":305,"top_left_y":2182,"width":725,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07a13e566112497c9988c758c94f366d","type":"text","conversion_output":true,"text":"performed to support the primary analysis.","text_display":" performed to support the primary analysis.","confidence":0.99951171875,"confidence_rate":0.9999896085540317},{"cnt":[[305,2269],[1807,2269],[1807,2318],[305,2318]],"region":{"top_left_x":305,"top_left_y":2268,"width":1502,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82dbb3af3b054de5a70a17c02ae1fd51","type":"text","conversion_output":true,"text":"Cognitive Function. A cognitive assessment battery will be administered at baseline and","text_display":"\n\nCognitive Function. A cognitive assessment battery will be administered at baseline and","confidence":1,"confidence_rate":1},{"cnt":[[305,2316],[1764,2316],[1764,2363],[305,2363]],"region":{"top_left_x":305,"top_left_y":2316,"width":1459,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8de76b8bc394c48b1be2ca08ce6fa96","type":"text","conversion_output":true,"text":"2 and 4 years post-randomization in a subsample of 2800 . The primary outcomes will","text_display":" 2 and 4 years post-randomization in a subsample of 2800 . The primary outcomes will","confidence":0.9576181983575225,"confidence_rate":0.9995344511887384},{"cnt":[[305,2359],[1721,2359],[1721,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1416,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"295a99c797c042ce81554484d7162a5a","type":"text","conversion_output":true,"text":"be composite scores for two domains: 1) Memory, consisting of the Hopkins Verbal","text_display":" be composite scores for two domains: 1) Memory, consisting of the Hopkins Verbal","confidence":0.99609375,"confidence_rate":0.9999539551857287},{"cnt":[[305,2402],[1639,2402],[1639,2451],[305,2451]],"region":{"top_left_x":305,"top_left_y":2401,"width":1335,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1530484305944cb3ad102b7eb6197462","type":"text","conversion_output":true,"text":"Learning Test, Logical Memory and the Modified Rey Osterrieth Figure, and 2)","text_display":" Learning Test, Logical Memory and the Modified Rey Osterrieth Figure, and 2)","confidence":0.98583984375,"confidence_rate":0.9998239492290454},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be00ecc87c634a59b6e5939a4069ccc3","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"709a8a798e2c4d22991559aaf2b75b09","type":"page_info","conversion_output":false,"text":"61","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2677],[1521,2677]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"944a756a895d4477a1f9acd15a709bb3","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-064","page":64,"lines":[{"cnt":[[309,251],[1725,251],[1725,299],[309,299]],"region":{"top_left_x":309,"top_left_y":251,"width":1417,"height":48},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"027162ab54124cd2a810a4886b9a895e","type":"text","conversion_output":true,"text":"Processing Speed, consisting of Trails Making Tests and Digit Symbol Coding Test.","text_display":"\n\nProcessing Speed, consisting of Trails Making Tests and Digit Symbol Coding Test.","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[309,296],[1738,296],[1738,342],[309,342]],"region":{"top_left_x":309,"top_left_y":296,"width":1430,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5afc4979057d48cebcd4032b1e0bd05b","type":"text","conversion_output":true,"text":"Changes in impairment over time will be compared between the two treatment arms.","text_display":" Changes in impairment over time will be compared between the two treatment arms.","confidence":1,"confidence_rate":1},{"cnt":[[309,382],[1652,382],[1652,432],[309,432]],"region":{"top_left_x":309,"top_left_y":382,"width":1344,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1441bf0663c14bc0b7a839115da0ed70","type":"text","conversion_output":true,"text":"Supporting analyses will also be conducted on the effect of the interventions on","text_display":"\n\nSupporting analyses will also be conducted on the effect of the interventions on","confidence":1,"confidence_rate":1},{"cnt":[[309,430],[1772,430],[1772,475],[309,475]],"region":{"top_left_x":309,"top_left_y":429,"width":1464,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b7de259d6544b0f89233603a2d91c5c","type":"text","conversion_output":true,"text":"individual domains of memory over 48 months. Follow-up test scores will be compared","text_display":" individual domains of memory over 48 months. Follow-up test scores will be compared","confidence":1,"confidence_rate":1},{"cnt":[[309,473],[1785,473],[1785,518],[309,518]],"region":{"top_left_x":309,"top_left_y":472,"width":1477,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"249fe3ee7c4642b28fe040e6ed1bd3e7","type":"text","conversion_output":true,"text":"using mixed-effects analysis of covariance models (Laird, 1982). Mixed-effects models","text_display":" using mixed-effects analysis of covariance models (Laird, 1982). Mixed-effects models","confidence":1,"confidence_rate":1},{"cnt":[[309,516],[1712,516],[1712,561],[309,561]],"region":{"top_left_x":309,"top_left_y":515,"width":1404,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5b6eae19a074924a41b47f7d0feedbb","type":"text","conversion_output":true,"text":"allow for departure from linearity in the relationship between the outcome and time.","text_display":" allow for departure from linearity in the relationship between the outcome and time.","confidence":1,"confidence_rate":1},{"cnt":[[309,559],[1641,559],[1641,599],[309,599]],"region":{"top_left_x":309,"top_left_y":558,"width":1333,"height":42},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a68fe9790e074f9a9cfe42a22eb6144a","type":"text","conversion_output":true,"text":"Estimates of the difference in mean levels of the outcome between control and","text_display":" Estimates of the difference in mean levels of the outcome between control and","confidence":1,"confidence_rate":1},{"cnt":[[309,604],[1807,604],[1807,649],[309,649]],"region":{"top_left_x":309,"top_left_y":603,"width":1498,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecf2050e75e3483fa9bb693b87e97409","type":"text","conversion_output":true,"text":"intervention groups will be obtained using maximum likelihood techniques. Sensitivity of","text_display":" intervention groups will be obtained using maximum likelihood techniques. Sensitivity of","confidence":1,"confidence_rate":1},{"cnt":[[309,649],[1674,649],[1674,694],[309,694]],"region":{"top_left_x":309,"top_left_y":648,"width":1365,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16ee89f1c67748cab70b30fb22b64db8","type":"text","conversion_output":true,"text":"results to missing data will be investigated through the use of multiple imputation","text_display":" results to missing data will be investigated through the use of multiple imputation","confidence":1,"confidence_rate":1},{"cnt":[[309,692],[750,692],[750,737],[309,737]],"region":{"top_left_x":309,"top_left_y":691,"width":441,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50da146f3a2b469baa5aecb70fe7140e","type":"text","conversion_output":true,"text":"techniques (Rubin, 1987).","text_display":" techniques (Rubin, 1987).","confidence":1,"confidence_rate":1},{"cnt":[[309,778],[1725,778],[1725,827],[309,827]],"region":{"top_left_x":309,"top_left_y":777,"width":1417,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6785880665ab4dd780b77a18ce4e4e08","type":"text","conversion_output":true,"text":"Magnetic Resonance Imaging (MRI). Other than age, hypertension is the strongest","text_display":"\n\nMagnetic Resonance Imaging (MRI). Other than age, hypertension is the strongest","confidence":1,"confidence_rate":1},{"cnt":[[309,821],[1747,821],[1747,868],[309,868]],"region":{"top_left_x":309,"top_left_y":820,"width":1438,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbf856c7a14741d49fbf69930fbbda93","type":"text","conversion_output":true,"text":"correlate of SVID. Total SVID lesion load including abnormal white matter, abnormal","text_display":" correlate of SVID. Total SVID lesion load including abnormal white matter, abnormal","confidence":1,"confidence_rate":1},{"cnt":[[309,868],[1813,868],[1813,913],[309,913]],"region":{"top_left_x":309,"top_left_y":867,"width":1505,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9d315359f864409b2646ee83cc0f596","type":"text","conversion_output":true,"text":"gray matter and abnormal basal ganglia will be the SPRINT measure of total SVID lesion","text_display":" gray matter and abnormal basal ganglia will be the SPRINT measure of total SVID lesion","confidence":1,"confidence_rate":1},{"cnt":[[309,911],[1813,911],[1813,956],[309,956]],"region":{"top_left_x":309,"top_left_y":910,"width":1505,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3acac49425c941d5a0bf53e401c7a005","type":"text","conversion_output":true,"text":"load. Differences in total SVID lesion between treatment groups at 48 months will be the","text_display":" load. Differences in total SVID lesion between treatment groups at 48 months will be the","confidence":1,"confidence_rate":1},{"cnt":[[309,954],[1764,954],[1764,999],[309,999]],"region":{"top_left_x":309,"top_left_y":953,"width":1455,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed1214da37da41509403b6bec5909f6e","type":"text","conversion_output":true,"text":"main outcomes of the MRI component. Furthermore, differences in total brain volume","text_display":" main outcomes of the MRI component. Furthermore, differences in total brain volume","confidence":1,"confidence_rate":1},{"cnt":[[309,997],[1727,997],[1727,1042],[309,1042]],"region":{"top_left_x":309,"top_left_y":996,"width":1419,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3be6d40cfa53466a9fbd77686c7c5852","type":"text","conversion_output":true,"text":"will also be compared after 48 months. These measures are continuous and will be","text_display":" will also be compared after 48 months. These measures are continuous and will be","confidence":1,"confidence_rate":1},{"cnt":[[309,1042],[1678,1042],[1678,1087],[309,1087]],"region":{"top_left_x":309,"top_left_y":1041,"width":1369,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54bc6007b31b40319f57eff6eac4a353","type":"text","conversion_output":true,"text":"analyzed using mixed effects analysis of covariance models as described above.","text_display":" analyzed using mixed effects analysis of covariance models as described above.","confidence":0.99609375,"confidence_rate":0.9999528456982913},{"cnt":[[309,1130],[1721,1130],[1721,1175],[309,1175]],"region":{"top_left_x":309,"top_left_y":1130,"width":1412,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c4b77a42fdf4511b83dec3ab4904bb6","type":"text","conversion_output":true,"text":"Mild Cognitive Impairment (MCI). This outcome is defined as the time to the first of","text_display":"\n\nMild Cognitive Impairment (MCI). This outcome is defined as the time to the first of","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[309,1173],[1714,1173],[1714,1220],[309,1220]],"region":{"top_left_x":309,"top_left_y":1173,"width":1406,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8854d8bb63564ef092b708eb92a00c75","type":"text","conversion_output":true,"text":"two consecutive occurrences of MCl . Analytical methods used for dementia will be","text_display":" two consecutive occurrences of MCl . Analytical methods used for dementia will be","confidence":0.7910114815458655,"confidence_rate":0.9974549528760626},{"cnt":[[309,1216],[1738,1216],[1738,1263],[309,1263]],"region":{"top_left_x":309,"top_left_y":1216,"width":1430,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32de1b8af51c45c1aa79a2e52d90a06e","type":"text","conversion_output":true,"text":"applied to the analyses of MCI, in those free of MCI at baseline. Furthermore, these","text_display":" applied to the analyses of MCI, in those free of MCI at baseline. 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Analyses of the cognitive outcomes will also explore the intervention effects","text_display":"\n\nSubgroups. Analyses of the cognitive outcomes will also explore the intervention effects","confidence":1,"confidence_rate":1},{"cnt":[[309,1437],[1813,1437],[1813,1485],[309,1485]],"region":{"top_left_x":309,"top_left_y":1437,"width":1505,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"396e1b36b3a547f8a7b9788710f8d03f","type":"text","conversion_output":true,"text":"within subgroups. The analytic approach will be the same as for the primary CV analysis","text_display":" within subgroups. The analytic approach will be the same as for the primary CV analysis","confidence":0.9873106479644775,"confidence_rate":0.9998611993131659},{"cnt":[[309,1482],[1085,1482],[1085,1528],[309,1528]],"region":{"top_left_x":309,"top_left_y":1482,"width":776,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a1aa4d12ad743b99114d3246dcdff7c","type":"text","conversion_output":true,"text":"as described in 10.1.2.2. The subgroups are:","text_display":" as described in 10.1.2.2. The subgroups are:","confidence":1,"confidence_rate":1},{"cnt":[[434,1525],[1523,1525],[1523,1571],[434,1571]],"region":{"top_left_x":433,"top_left_y":1525,"width":1091,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1d78b7b4b36450391b2d15a9433a5e4","type":"text","conversion_output":true,"text":"a) CKD (defined as eGFR < 60 at randomization) vs. non-CKD,","text_display":"\na) CKD (defined as eGFR < 60 at randomization) vs. non-CKD,","confidence":0.781087742652744,"confidence_rate":0.9963192118305826},{"cnt":[[434,1568],[1588,1568],[1588,1618],[434,1618]],"region":{"top_left_x":433,"top_left_y":1568,"width":1155,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"759d2af1e03b4dec9ca9af10bbc867f3","type":"text","conversion_output":true,"text":"b) senior vs. non-senior (aged \\(75+\\) at randomization vs. aged \\(<75\\) ),","text_display":"\nb) senior vs. non-senior (aged \\(75+\\) at 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non-black,","confidence":1,"confidence_rate":1},{"cnt":[[434,1702],[1800,1702],[1800,1747],[434,1747]],"region":{"top_left_x":433,"top_left_y":1701,"width":1368,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7461ca2815254a2fa0ce72ee1fc208b0","type":"text","conversion_output":true,"text":"e) with and without a history of CVD at randomization (as defined in Chapter 3),","text_display":"\ne) with and without a history of CVD at randomization (as defined in Chapter 3),","confidence":1,"confidence_rate":1},{"cnt":[[432,1745],[1261,1745],[1261,1790],[432,1790]],"region":{"top_left_x":431,"top_left_y":1744,"width":831,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80ea24317fe54dcd960681175fa61bd0","type":"text","conversion_output":true,"text":"f) tertiles of systolic blood pressure at baseline,","text_display":"\nf) tertiles of systolic blood pressure at 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Exploratory","text_display":"\n\nWe expect to explore fully the rich set of data that SPRINT will obtain. Exploratory","confidence":1,"confidence_rate":1},{"cnt":[[309,2185],[1811,2185],[1811,2228],[309,2228]],"region":{"top_left_x":309,"top_left_y":2184,"width":1503,"height":44},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2f1ad8dac364e9f98198acc4d9e33c7","type":"text","conversion_output":true,"text":"analyses of biologically plausible subgroups are of particular interest. Some of these will","text_display":" analyses of biologically plausible subgroups are of particular interest. Some of these will","confidence":1,"confidence_rate":1},{"cnt":[[309,2228],[1682,2228],[1682,2273],[309,2273]],"region":{"top_left_x":309,"top_left_y":2227,"width":1374,"height":47},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"080bd82d7b5548fcad410e0a45de7f14","type":"text","conversion_output":true,"text":"be further articulation of supporting subgroup analyses described above, such as","text_display":" be further articulation of supporting subgroup analyses described above, such as","confidence":1,"confidence_rate":1},{"cnt":[[309,2273],[1772,2273],[1772,2318],[309,2318]],"region":{"top_left_x":309,"top_left_y":2273,"width":1464,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0020d984229c450eacde916323b42189","type":"text","conversion_output":true,"text":"analysis of continuous baseline factors as continuous variables rather as pre-specified","text_display":" analysis of continuous baseline factors as continuous variables rather as pre-specified","confidence":1,"confidence_rate":1},{"cnt":[[309,2316],[1777,2316],[1777,2361],[309,2361]],"region":{"top_left_x":309,"top_left_y":2316,"width":1468,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab5f5d23706e47f38efd661993d9cd1e","type":"text","conversion_output":true,"text":"categorical variables. Other analyses will involve baseline variables that are not listed","text_display":" categorical variables. Other analyses will involve baseline variables that are not listed","confidence":1,"confidence_rate":1},{"cnt":[[309,2359],[1766,2359],[1766,2404],[309,2404]],"region":{"top_left_x":309,"top_left_y":2358,"width":1458,"height":47},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"296e35caba5f4c27b47f629e14dd4138","type":"text","conversion_output":true,"text":"in the pre-specified subgroup but which may modify treatment effect, such as diastolic","text_display":" in the pre-specified subgroup but which may modify treatment effect, such as diastolic","confidence":1,"confidence_rate":1},{"cnt":[[309,2402],[1248,2402],[1248,2451],[309,2451]],"region":{"top_left_x":309,"top_left_y":2401,"width":940,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f603dc3a3844f6b87cd201a68a83f26","type":"text","conversion_output":true,"text":"blood pressure or presence of the metabolic syndrome.","text_display":" blood pressure or presence of the metabolic syndrome.","confidence":1,"confidence_rate":1},{"cnt":[[309,2638],[492,2638],[492,2673],[309,2673]],"region":{"top_left_x":309,"top_left_y":2638,"width":183,"height":35},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b66dd2a4ab744379a2c408279b09d3e1","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"976efcfc0e8b4e9cbe2cc3dc60a126d1","type":"page_info","conversion_output":false,"text":"62","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1525,2638],[1815,2638],[1815,2675],[1525,2675]],"region":{"top_left_x":1525,"top_left_y":2638,"width":291,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63fc166a7d674bca9b04dc90aa94c51c","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-065","page":65,"lines":[{"cnt":[[303,288],[681,288],[681,346],[303,346]],"region":{"top_left_x":302,"top_left_y":287,"width":380,"height":59},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"389c71e605734d32b8eac0e738869c66","type":"section_header","conversion_output":false,"children_ids":["a709f939676640ff89d186e461400779"],"text":"","text_display":""},{"cnt":[[309,292],[677,292],[677,342],[309,342]],"region":{"top_left_x":309,"top_left_y":292,"width":368,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a709f939676640ff89d186e461400779","type":"text","conversion_output":true,"parent_id":"389c71e605734d32b8eac0e738869c66","text":"10.1.5 Missing data","text_display":"\n\n\\subsection*{10.1.5 Missing data}","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1820,382],[1820,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1515,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"349cf7a43c254796ae66bf6a630875e9","type":"text","conversion_output":true,"text":"Consistent with an intention-to-treat analysis, we will categorize all participants by their","text_display":"\n\nConsistent with an intention-to-treat analysis, we will categorize all participants by their","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[305,425],[1818,425],[1818,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1513,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a46c378d657d40989979be6be777971b","type":"text","conversion_output":true,"text":"randomization group, regardless of compliance, in our primary analyses. For those","text_display":" randomization group, regardless of compliance, in our primary analyses. For those","confidence":1,"confidence_rate":1},{"cnt":[[305,468],[1820,468],[1820,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1515,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b43540102484a8788bd5cabf2bfae5a","type":"text","conversion_output":true,"text":"participants lost to follow-up, we plan to use all available information until the time of","text_display":" participants lost to follow-up, we plan to use all available information until the time of","confidence":1,"confidence_rate":1},{"cnt":[[305,516],[750,516],[750,561],[305,561]],"region":{"top_left_x":305,"top_left_y":515,"width":445,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"632d4e512d9f4bc2bfbb838770b339c7","type":"text","conversion_output":true,"text":"death or loss to follow-up.","text_display":" death or loss to follow-up.","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1818,602],[1818,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1513,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f399a40d8f248ed843fb7f4be212c42","type":"text","conversion_output":true,"text":"Our approach to handling missing outcomes in clinical trials is consistent with the","text_display":"\n\nOur approach to handling missing outcomes in clinical trials is consistent with the","confidence":1,"confidence_rate":1},{"cnt":[[305,645],[1815,645],[1815,694],[305,694]],"region":{"top_left_x":305,"top_left_y":644,"width":1511,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e76b0f1a0c34a818e79583d57b925f2","type":"text","conversion_output":true,"text":"opinion of Molenberghs and Kenward (2007, p9), who state that while ignorable,","text_display":" opinion of Molenberghs and Kenward (2007, p9), who state that while ignorable,","confidence":0.99951171875,"confidence_rate":0.999994115673962},{"cnt":[[305,692],[1815,692],[1815,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1511,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae926cb6918b473f9c4ca03d16380453","type":"text","conversion_output":true,"text":"missing-at-random (MAR) analyses are reasonable for the primary analysis, exploration","text_display":" missing-at-random (MAR) analyses are reasonable for the primary analysis, exploration","confidence":1,"confidence_rate":1},{"cnt":[[305,735],[1818,735],[1818,780],[305,780]],"region":{"top_left_x":305,"top_left_y":734,"width":1513,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a8891209fa94de3a3e5e98ae254925d","type":"text","conversion_output":true,"text":"of the sensitivity of conclusion to the MAR assumption may include models which allow","text_display":" of the sensitivity of conclusion to the MAR assumption may include models which allow","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[1815,778],[1815,827],[305,827]],"region":{"top_left_x":305,"top_left_y":777,"width":1511,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61ea4ed114514c9b890ed6dfb689a6ec","type":"text","conversion_output":true,"text":"for missingness that is not random. If loss to follow-up is related to the level of the","text_display":" for missingness that is not random. If loss to follow-up is related to the level of the","confidence":1,"confidence_rate":1},{"cnt":[[305,821],[1815,821],[1815,870],[305,870]],"region":{"top_left_x":305,"top_left_y":820,"width":1511,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"945eecba887f4e4da059c8b704560628","type":"text","conversion_output":true,"text":"outcome being analyzed (e.g. as often occurs when analyzing health related outcomes),","text_display":" outcome being analyzed (e.g. as often occurs when analyzing health related outcomes),","confidence":1,"confidence_rate":1},{"cnt":[[305,866],[1815,866],[1815,913],[305,913]],"region":{"top_left_x":305,"top_left_y":865,"width":1511,"height":49},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f92681eee089416c8cc6702acb029c5a","type":"text","conversion_output":true,"text":"then results obtained under the assumption of independent loss to follow-up may be","text_display":" then results obtained under the assumption of independent loss to follow-up may be","confidence":1,"confidence_rate":1},{"cnt":[[305,911],[1815,911],[1815,956],[305,956]],"region":{"top_left_x":305,"top_left_y":910,"width":1511,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df8eb9928a984272a3ae7de09cfb6778","type":"text","conversion_output":true,"text":"biased. The magnitude of this problem will be investigated by using measurements","text_display":" biased. The magnitude of this problem will be investigated by using measurements","confidence":1,"confidence_rate":1},{"cnt":[[305,954],[1815,954],[1815,1001],[305,1001]],"region":{"top_left_x":305,"top_left_y":953,"width":1511,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be618c32caae4e7a9ab92cb20b7ab8c2","type":"text","conversion_output":true,"text":"taken at previous visits to predict loss to follow-up. Variables determined to predict loss","text_display":" taken at previous visits to predict loss to follow-up. Variables determined to predict loss","confidence":1,"confidence_rate":1},{"cnt":[[305,997],[1815,997],[1815,1044],[305,1044]],"region":{"top_left_x":305,"top_left_y":996,"width":1511,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfe7d311161041eb932f815e6a5f6e21","type":"text","conversion_output":true,"text":"to follow-up will be included in our predictive models in order to satisfy the conditions","text_display":" to follow-up will be included in our predictive models in order to satisfy the conditions","confidence":1,"confidence_rate":1},{"cnt":[[305,1040],[1815,1040],[1815,1089],[305,1089]],"region":{"top_left_x":305,"top_left_y":1039,"width":1511,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04ef53e4a6cc4a1998868fac7cc4d30a","type":"text","conversion_output":true,"text":"described by Little and Rubin (1987) for the data to be considered MAR. Maximum","text_display":" described by Little and Rubin (1987) for the data to be considered MAR. Maximum","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[305,1087],[1818,1087],[1818,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":1513,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c7c697ca7f941f98a68d7eb6a5455b6","type":"text","conversion_output":true,"text":"likelihood techniques will be used to estimate parameters. If necessary, other","text_display":" likelihood techniques will be used to estimate parameters. If necessary, other","confidence":1,"confidence_rate":1},{"cnt":[[305,1130],[1815,1130],[1815,1175],[305,1175]],"region":{"top_left_x":305,"top_left_y":1130,"width":1511,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0be92799e0e45b3a818eec55f2fbb90","type":"text","conversion_output":true,"text":"approaches may be examined in consideration of how robust the results will be and","text_display":" approaches may be examined in consideration of how robust the results will be and","confidence":1,"confidence_rate":1},{"cnt":[[305,1173],[1502,1173],[1502,1222],[305,1222]],"region":{"top_left_x":305,"top_left_y":1173,"width":1197,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"205deb0255a94d89ae480ea8a3080baa","type":"text","conversion_output":true,"text":"whether they provide appropriately conservative estimates for the trial.","text_display":" whether they provide appropriately conservative estimates for the trial.","confidence":1,"confidence_rate":1},{"cnt":[[305,1259],[1815,1259],[1815,1308],[305,1308]],"region":{"top_left_x":305,"top_left_y":1258,"width":1511,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c1a8770ee2d4004a34025f76c22c275","type":"text","conversion_output":true,"text":"In order to explore the possibility of a relationship between ESRD and CV outcomes, we","text_display":"\n\nIn order to explore the possibility of a relationship between ESRD and CV outcomes, we","confidence":1,"confidence_rate":1},{"cnt":[[305,1306],[1815,1306],[1815,1351],[305,1351]],"region":{"top_left_x":305,"top_left_y":1306,"width":1511,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae8fa425f04a427998e88b6b078b7e2e","type":"text","conversion_output":true,"text":"will conduct sensitivity analyses which treat ESRD as a censoring point for the primary","text_display":" will conduct sensitivity analyses which treat ESRD as a censoring point for the primary","confidence":1,"confidence_rate":1},{"cnt":[[305,1349],[1815,1349],[1815,1396],[305,1396]],"region":{"top_left_x":305,"top_left_y":1349,"width":1511,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"112b03cc12d640c99c980bb9cdf1a601","type":"text","conversion_output":true,"text":"outcome. This exploration may include an auxiliary composite outcome combining the","text_display":" outcome. This exploration may include an auxiliary composite outcome combining the","confidence":1,"confidence_rate":1},{"cnt":[[305,1392],[1029,1392],[1029,1442],[305,1442]],"region":{"top_left_x":305,"top_left_y":1392,"width":725,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a0dff3ee84845d4b916ab94cfaa6654","type":"text","conversion_output":true,"text":"events in the primary outcome and ESRD.","text_display":" events in the primary outcome and ESRD.","confidence":1,"confidence_rate":1},{"cnt":[[305,1480],[1815,1480],[1815,1528],[305,1528]],"region":{"top_left_x":305,"top_left_y":1480,"width":1511,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b377dc6fc4794681a02c83e5811a87b7","type":"text","conversion_output":true,"text":"Robustness of inferences to missing outcome data will be further explored in sensitivity","text_display":"\n\nRobustness of inferences to missing outcome data will be further explored in sensitivity","confidence":1,"confidence_rate":1},{"cnt":[[305,1525],[1815,1525],[1815,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1525,"width":1511,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6211d0b928014f6f86a971f93e393ccb","type":"text","conversion_output":true,"text":"analyses. These analyses will include examination of several \"worst-case\" scenarios,","text_display":" analyses. These analyses will include examination of several \"worst-case\" scenarios,","confidence":1,"confidence_rate":1},{"cnt":[[305,1568],[1815,1568],[1815,1613],[305,1613]],"region":{"top_left_x":305,"top_left_y":1568,"width":1511,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0279e4fd19ca41a7be7cddff4c5bd426","type":"text","conversion_output":true,"text":"including opposite and pooled imputation approaches (Wittes, Lakatos \\& Probstfield","text_display":" including opposite and pooled imputation approaches (Wittes, Lakatos \\& Probstfield","confidence":1,"confidence_rate":1},{"cnt":[[305,1611],[1815,1611],[1815,1659],[305,1659]],"region":{"top_left_x":305,"top_left_y":1611,"width":1511,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56b2408659d6495195341521929e6878","type":"text","conversion_output":true,"text":"1989; Proschan et al., 2001). These types of scenarios are members of a broad class","text_display":" 1989; Proschan et al., 2001). These types of scenarios are members of a broad class","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[305,1656],[1815,1656],[1815,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1656,"width":1511,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da2c0cb866a941d0a25cd812c392058c","type":"text","conversion_output":true,"text":"that can be parameterized as pattern mixture models (Little 1993) and allow for","text_display":" that can be parameterized as pattern mixture models (Little 1993) and allow for","confidence":1,"confidence_rate":1},{"cnt":[[305,1702],[1815,1702],[1815,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1701,"width":1511,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"229483cc502343efa363f897e4bc0d94","type":"text","conversion_output":true,"text":"examination of sensitivity of conclusions to missing-not-at-random (MNAR) mechanisms","text_display":" examination of sensitivity of conclusions to missing-not-at-random (MNAR) mechanisms","confidence":0.99658203125,"confidence_rate":0.9999615308146822},{"cnt":[[305,1745],[896,1745],[896,1794],[305,1794]],"region":{"top_left_x":305,"top_left_y":1744,"width":591,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"299d49b773464208bff2b30693327e62","type":"text","conversion_output":true,"text":"(Mohlenberg and Kenward, 2007).","text_display":" (Mohlenberg and Kenward, 2007).","confidence":1,"confidence_rate":1},{"cnt":[[305,1830],[1818,1830],[1818,1880],[305,1880]],"region":{"top_left_x":305,"top_left_y":1830,"width":1513,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca80108e2930484987420e98666ae98f","type":"text","conversion_output":true,"text":"The MRI substudy involves two assessments-one at baseline and one at 48 months-","text_display":"\n\nThe MRI substudy involves two assessments-one at baseline and one at 48 months","confidence":1,"confidence_rate":1},{"cnt":[[305,1876],[1815,1876],[1815,1923],[305,1923]],"region":{"top_left_x":305,"top_left_y":1875,"width":1511,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb5223d656194226b933627f5b6930e7","type":"text","conversion_output":true,"text":"in 640 participants, thus limiting the range of analytic strategies. We recommend using","text_display":"in 640 participants, thus limiting the range of analytic strategies. We recommend using","confidence":1,"confidence_rate":1},{"cnt":[[305,1921],[1815,1921],[1815,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":1511,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3332f9ab9de49d7b5e727235b5eccf9","type":"text","conversion_output":true,"text":"maximum likelihood based general linear models for analyzing outcomes. Intracranial","text_display":" maximum likelihood based general linear models for analyzing outcomes. Intracranial","confidence":1,"confidence_rate":1},{"cnt":[[305,1964],[1815,1964],[1815,2009],[305,2009]],"region":{"top_left_x":305,"top_left_y":1963,"width":1511,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a78f1197f0a94d718f67b26ab733981b","type":"text","conversion_output":true,"text":"volume will be included as a covariate. The validity of the MAR assumption can be","text_display":" volume will be included as a covariate. The validity of the MAR assumption can be","confidence":1,"confidence_rate":1},{"cnt":[[305,2007],[1815,2007],[1815,2054],[305,2054]],"region":{"top_left_x":305,"top_left_y":2006,"width":1511,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1567646daff0424194a4365e002258d9","type":"text","conversion_output":true,"text":"improved by including baseline covariates that predict missingness. If loss to follow-up","text_display":" improved by including baseline covariates that predict missingness. If loss to follow-up","confidence":1,"confidence_rate":1},{"cnt":[[305,2052],[1815,2052],[1815,2099],[305,2099]],"region":{"top_left_x":305,"top_left_y":2051,"width":1511,"height":49},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e78853aa5624268a54f554f29d4af93","type":"text","conversion_output":true,"text":"is related to the unobserved cognitive outcome then our results may be biased. Again,","text_display":" is related to the unobserved cognitive outcome then our results may be biased. Again,","confidence":1,"confidence_rate":1},{"cnt":[[305,2093],[1665,2093],[1665,2142],[305,2142]],"region":{"top_left_x":305,"top_left_y":2092,"width":1361,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"693b7df63f9c4975a43534d9c292b7ae","type":"text","conversion_output":true,"text":"some modeling and sensitivity analysis options may be considered if necessary.","text_display":" some modeling and sensitivity analysis options may be considered if necessary.","confidence":1,"confidence_rate":1},{"cnt":[[301,2176],[1317,2176],[1317,2237],[301,2237]],"region":{"top_left_x":300,"top_left_y":2176,"width":1017,"height":61},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83b06891bf504b02b32d81b11f873228","type":"section_header","conversion_output":false,"children_ids":["64fcfc4509c844518dc05c88ed6f38af"],"text":"","text_display":""},{"cnt":[[305,2183],[1313,2183],[1313,2230],[305,2230]],"region":{"top_left_x":305,"top_left_y":2182,"width":1008,"height":49},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64fcfc4509c844518dc05c88ed6f38af","type":"text","conversion_output":true,"parent_id":"83b06891bf504b02b32d81b11f873228","text":"10.2 Sample Size Estimation and Power Calculations","text_display":"\n\n\\subsection*{10.2 Sample Size Estimation and Power Calculations}","confidence":1,"confidence_rate":1},{"cnt":[[301,2264],[765,2264],[765,2322],[301,2322]],"region":{"top_left_x":300,"top_left_y":2264,"width":465,"height":59},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6be3b09091d428898d5d6592e1d3f79","type":"section_header","conversion_output":false,"children_ids":["6b6c5a6daa1843dea911ac25beca5843"],"text":"","text_display":""},{"cnt":[[309,2269],[758,2269],[758,2318],[309,2318]],"region":{"top_left_x":309,"top_left_y":2268,"width":450,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b6c5a6daa1843dea911ac25beca5843","type":"text","conversion_output":true,"parent_id":"d6be3b09091d428898d5d6592e1d3f79","text":"10.2.1 Primary Outcome","text_display":"\n\n\\subsection*{10.2.1 Primary Outcome}","confidence":1,"confidence_rate":1},{"cnt":[[305,2359],[1811,2359],[1811,2408],[305,2408]],"region":{"top_left_x":305,"top_left_y":2358,"width":1507,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dca71bda1a0c43d2b504ac1c13dc2c6a","type":"text","conversion_output":true,"text":"We have assumed a \\(2.2 \\% / yr\\) event rate of the primary outcome in the standard group, a","text_display":"\n\nWe have assumed a \\(2.2 \\% / yr\\) event rate of the primary outcome in the standard group, a","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[305,2402],[1790,2402],[1790,2451],[305,2451]],"region":{"top_left_x":305,"top_left_y":2401,"width":1485,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37441beb41c541de9f91c4ae53e09428","type":"text","conversion_output":true,"text":"\\(20 \\%\\) effect size for the intervention (hazard ratio of 0.8 ), a two-year uniform recruitment","text_display":" \\(20 \\%\\) effect size for the intervention (hazard ratio of 0.8 ), a two-year uniform recruitment","confidence":0.9956073760986328,"confidence_rate":0.9999550795822252},{"cnt":[[305,2445],[1781,2445],[1781,2494],[305,2494]],"region":{"top_left_x":305,"top_left_y":2444,"width":1477,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"725698de190d4b488f249ec1efa3eb05","type":"text","conversion_output":true,"text":"period, a total study length of 5 years and 10 months, a \\(2 \\% / yr\\) rate of loss to follow-up,","text_display":" period, a total study length of 5 years and 10 months, a \\(2 \\% / yr\\) rate of loss to follow-up,","confidence":0.941057151183486,"confidence_rate":0.99942703772711},{"cnt":[[305,2634],[492,2634],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2633,"width":187,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34d1cbe780cf4b6499b272e4d5b50c88","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bd8e03165334881a7b3c46c4fd4e4b2","type":"page_info","conversion_output":false,"text":"63","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2675],[1521,2675]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45c7b97607d34899858a414673a42ffb","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-066","page":66,"lines":[{"cnt":[[305,249],[1740,249],[1740,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1436,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1e71dd4eeb14229bb067eecf049b6f2","type":"text","conversion_output":true,"text":"and a two-sided test at the \\(5 \\%\\) level. With these assumptions, power for a variety of","text_display":"\nand a two-sided test at the \\(5 \\%\\) level. With these assumptions, power for a variety of","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[305,294],[1790,294],[1790,342],[305,342]],"region":{"top_left_x":305,"top_left_y":294,"width":1485,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d95af395e964c3cab8eec2f8bcaa1ea","type":"text","conversion_output":true,"text":"sample sizes is presented in Table 1. Power is also presented for hazard ratios of 0.78","text_display":" sample sizes is presented in Table 1. Power is also presented for hazard ratios of 0.78","confidence":1,"confidence_rate":1},{"cnt":[[305,339],[1772,339],[1772,387],[305,387]],"region":{"top_left_x":305,"top_left_y":339,"width":1468,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ae6d95b12bf4b75857f18f07712a66c","type":"text","conversion_output":true,"text":"and 0.82 and for event rates of 2.0 and \\(2.4 \\% / yr\\). A sample size of 9250 provides high","text_display":" and 0.82 and for event rates of 2.0 and \\(2.4 \\% / yr\\). A sample size of 9250 provides high","confidence":0.9985356330871582,"confidence_rate":0.9999860435245741},{"cnt":[[305,382],[1745,382],[1745,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1440,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b040f9b6e77469ab8c7fc782086540e","type":"text","conversion_output":true,"text":"power for a hazard ratio of 0.8 (representing a \\(20 \\%\\) effect) and a \\(2.2 \\% / yr\\) event rate.","text_display":" power for a hazard ratio of 0.8 (representing a \\(20 \\%\\) effect) and a \\(2.2 \\% / yr\\) event rate.","confidence":0.8846967830322683,"confidence_rate":0.9987996395319809},{"cnt":[[305,425],[1783,425],[1783,475],[305,475]],"region":{"top_left_x":305,"top_left_y":425,"width":1479,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f72b11029de4aa48407611b9f248e85","type":"text","conversion_output":true,"text":"This sample size would also provide over \\(80 \\%\\) power for an effect of \\(18 \\%\\) (hazard ratio","text_display":" This sample size would also provide over \\(80 \\%\\) power for an effect of \\(18 \\%\\) (hazard ratio","confidence":0.995610237121582,"confidence_rate":0.9999541736940408},{"cnt":[[305,468],[1798,468],[1798,518],[305,518]],"region":{"top_left_x":305,"top_left_y":468,"width":1494,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d45e6fd2fd0a4b289c89f33bf7e13283","type":"text","conversion_output":true,"text":"of 0.82 ) with an event rate of \\(2.2 \\% / yr\\) and would have reasonable power of \\(77.3 \\%\\) even","text_display":" of 0.82 ) with an event rate of \\(2.2 \\% / yr\\) and would have reasonable power of \\(77.3 \\%\\) even","confidence":0.9956109506310895,"confidence_rate":0.9999568763266917},{"cnt":[[305,513],[1764,513],[1764,561],[305,561]],"region":{"top_left_x":305,"top_left_y":513,"width":1459,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0710ac24ebe34364859f42fbdb1e6c7f","type":"text","conversion_output":true,"text":"with a smaller than assumed event rate of \\(2.0 \\% / yr\\) and an \\(18 \\%\\) effect. Depending on","text_display":" with a smaller than assumed event rate of \\(2.0 \\% / yr\\) and an \\(18 \\%\\) effect. Depending on","confidence":0.9970715045928955,"confidence_rate":0.9999691289834682},{"cnt":[[305,559],[1818,559],[1818,606],[305,606]],"region":{"top_left_x":305,"top_left_y":558,"width":1513,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd56ae71910b4abfac54473e367f5c79","type":"text","conversion_output":true,"text":"the observed event rate and treatment effect, the table below shows that sample sizes of","text_display":" the observed event rate and treatment effect, the table below shows that sample sizes of","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1199,602],[1199,651],[305,651]],"region":{"top_left_x":305,"top_left_y":601,"width":894,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"936dba613aae45839a6e3a669dc46dde","type":"text","conversion_output":true,"text":"8500 to 10000 would be consistent with study goals.","text_display":" 8500 to 10000 would be consistent with study 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\\multicolumn{10}{|l|}{Table 1: Power for the SPRINT primary outcome.} \\\\\n\\hline & \\multicolumn{9}{|c|}{Event Rate} \\\\\n\\hline & \\multicolumn{3}{|c|}{2.0 \\%/yr} & \\multicolumn{3}{|c|}{2.2 \\%/yr} & \\multicolumn{3}{|c|}{2.4 \\%/yr} \\\\\n\\hline N\\Hazard Ratio & 0.78 & 0.8 & 0.82 & 0.78 & 0.8 & 0.82 & 0.78 & 0.8 & 0.82 \\\\\n\\hline 8500 & 89.4 & 82.7 & 73.7 & 91.9 & 85.9 & 77.6 & 93.9 & 88.6 & 80.9 \\\\\n\\hline 8750 & 90.3 & 83.7 & 75.0 & 92.6 & 86.9 & 78.7 & 94.5 & 89.5 & 82.0 \\\\\n\\hline 9000 & 91.0 & 84.7 & 76.1 & 93.3 & 87.8 & 79.8 & 95.0 & 90.3 & 83.0 \\\\\n\\hline 9250 & 91.7 & 85.7 & 77.3 & 93.9 & 88.7 & 80.9 & 95.5 & 91.0 & 84.0 \\\\\n\\hline 9500 & 92.4 & 86.6 & 78.3 & 94.4 & 89.4 & 81.9 & 95.9 & 91.7 & 85.0 \\\\\n\\hline 9750 & 93.0 & 87.4 & 79.4 & 94.9 & 90.2 & 82.9 & 96.4 & 92.4 & 85.9 \\\\\n\\hline 10000 & 93.6 & 88.2 & 80.4 & 95.4 & 90.9 & 83.8 & 96.7 & 93.0 & 86.7 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Details of the event rate estimation are given in Appendix","text_display":" and \\(3 \\% / yr\\) loss to follow-up. Details of the event rate estimation are given in Appendix","confidence":0.9892756876070052,"confidence_rate":0.99988998327367},{"cnt":[[305,1005],[352,1005],[352,1048],[305,1048]],"region":{"top_left_x":305,"top_left_y":1005,"width":48,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69f63a7a63ad41f1ae07d56b58b4d288","type":"text","conversion_output":true,"text":"3.","text_display":" 3.","confidence":1,"confidence_rate":1},{"cnt":[[344,1085],[1781,1085],[1781,1330],[344,1330]],"region":{"top_left_x":343,"top_left_y":1084,"width":1439,"height":246},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd7c781e04c543fc849c9deb8f91b938","type":"table","conversion_output":true,"text":"\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline \\multicolumn{6}{|c|}{ Table 10.2. Power for the SPRINT MIND primary outcomes. } \\\\\n\\hline & \\multicolumn{5}{|c|}{ Event Rate (\\%/yr) } \\\\\n\\hline Hazard Ratio & 3.1 & 3.2 & 3.3 & 3.4 & 3.5 \\\\\n\\hline 0.80 & 96.3 & 96.7 & 97.1 & 97.4 & 97.7 \\\\\n\\hline 0.85 & 79.0 & 80.2 & 81.3 & 82.4 & 83.4 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline \\multicolumn{6}{|c|}{ Table 10.2. 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The report details the recommended \"windows\" that","text_display":" visits is automatically generated. 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Other key study personnel (e.g.,","text_display":" annually so that each PI has the opportunity to serve). 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These subcommittees and groups and their charges are detailed","text_display":" Steering Committee. 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The SPRINT DSMB may include experts in","confidence":1,"confidence_rate":1},{"cnt":[[305,2447],[1687,2447],[1687,2494],[305,2494]],"region":{"top_left_x":305,"top_left_y":2447,"width":1382,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2ed37488c254d1392d8b00d4fe80229","type":"text","conversion_output":true,"text":"cardiovascular medicine (particularly hypertension), kidney disease, clinical trials,","text_display":" cardiovascular medicine (particularly hypertension), kidney disease, clinical trials,","confidence":1,"confidence_rate":1},{"cnt":[[305,2638],[492,2638],[492,2675],[305,2675]],"region":{"top_left_x":305,"top_left_y":2638,"width":187,"height":37},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5aaf37b933e84703874f7a4d2c46cae6","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1038,2638],[1089,2638],[1089,2679],[1038,2679]],"region":{"top_left_x":1037,"top_left_y":2638,"width":53,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8467f2c13dd049fd827502c8e31b896a","type":"page_info","conversion_output":false,"text":"79","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2634],[1815,2634],[1815,2675],[1521,2675]],"region":{"top_left_x":1521,"top_left_y":2633,"width":295,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"797eadea78594f9ba397bc59e081b0f9","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-082","page":82,"lines":[{"cnt":[[305,249],[1811,249],[1811,299],[305,299]],"region":{"top_left_x":305,"top_left_y":249,"width":1507,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2d79f9409b54faa9056589a716d340d","type":"text","conversion_output":true,"text":"geriatrics, biostatistics, bioethics, quality of life, cost effectiveness, cognitive function and","text_display":"\ngeriatrics, biostatistics, bioethics, quality of life, cost effectiveness, cognitive function and","confidence":1,"confidence_rate":1},{"cnt":[[305,296],[1785,296],[1785,342],[305,342]],"region":{"top_left_x":305,"top_left_y":296,"width":1481,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b8cb8d6ef384ac9811974f37dbca2ac","type":"text","conversion_output":true,"text":"other areas as needed. DSMB participants include the Steering Committee Chair (who","text_display":" other areas as needed. DSMB participants include the Steering Committee Chair (who","confidence":1,"confidence_rate":1},{"cnt":[[305,339],[1553,339],[1553,387],[305,387]],"region":{"top_left_x":305,"top_left_y":339,"width":1249,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ed7601bd1fd470b9a25988a2f2a8c97","type":"text","conversion_output":true,"text":"is unblinded) and Vice-Chair (who is blinded), CC PI and senior staff, and","text_display":" is unblinded) and Vice-Chair (who is blinded), CC PI and senior staff, and","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1742,382],[1742,432],[305,432]],"region":{"top_left_x":305,"top_left_y":382,"width":1438,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99f2330c55f64396a3fface8080cc54e","type":"text","conversion_output":true,"text":"representatives from the NHLBI and other NIH sponsors. The DSMB normally meets","text_display":" representatives from the NHLBI and other NIH sponsors. 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In addition, the CC may provide data to the DSMB","text_display":" continuation and protocol changes. In addition, the CC may provide data to the DSMB","confidence":1,"confidence_rate":1},{"cnt":[[305,559],[1717,559],[1717,604],[305,604]],"region":{"top_left_x":305,"top_left_y":558,"width":1412,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c201fc8c2ff7451fb9ed3198c6f8863e","type":"text","conversion_output":true,"text":"Chair to ensure early identification of any major adverse outcomes of therapy. The","text_display":" Chair to ensure early identification of any major adverse outcomes of therapy. The","confidence":1,"confidence_rate":1},{"cnt":[[305,602],[1682,602],[1682,649],[305,649]],"region":{"top_left_x":305,"top_left_y":601,"width":1378,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32df000fd6d84476b9ce631bf7b68e30","type":"text","conversion_output":true,"text":"DSMB has the responsibility to recommend to the NHLBI whether the trial should","text_display":" DSMB has the responsibility to recommend to the NHLBI whether the trial should","confidence":1,"confidence_rate":1},{"cnt":[[305,647],[1729,647],[1729,694],[305,694]],"region":{"top_left_x":305,"top_left_y":646,"width":1425,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a41ba3e1a0514a37a22985bcccc8d46b","type":"text","conversion_output":true,"text":"continue, whether the protocol should be modified, or whether there should be early","text_display":" continue, whether the protocol should be modified, or whether there should be early","confidence":1,"confidence_rate":1},{"cnt":[[305,692],[1663,692],[1663,737],[305,737]],"region":{"top_left_x":305,"top_left_y":691,"width":1358,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"853078536ea04580b6887cd0ee6ff9c7","type":"text","conversion_output":true,"text":"termination. 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This policy was developed to meet two goals. First, the","text_display":" is presented in the MOP. This policy was developed to meet two goals. 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The policy applies to all investigators analyzing,","confidence":1,"confidence_rate":1},{"cnt":[[305,1702],[1738,1702],[1738,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1701,"width":1434,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c77ec4955f7549158154c4926a1156a1","type":"text","conversion_output":true,"text":"presenting, and publishing data from main SPRINT, SPRINT-MIND, SPRINT-Senior","text_display":" presenting, and publishing data from main SPRINT, SPRINT-MIND, SPRINT-Senior","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1783,1745],[1783,1792],[305,1792]],"region":{"top_left_x":305,"top_left_y":1744,"width":1479,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d5371d68c7e45908bd22753e36dd857","type":"text","conversion_output":true,"text":"(hereafter collectively called \"SPRINT\")and ancillary studies, except for those using the","text_display":" (hereafter collectively called \"SPRINT\")and ancillary studies, except for those using the","confidence":1,"confidence_rate":1},{"cnt":[[305,1788],[1502,1788],[1502,1837],[305,1837]],"region":{"top_left_x":305,"top_left_y":1787,"width":1197,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"037220adf29545a78ec3980bab8a11f6","type":"text","conversion_output":true,"text":"NHLBI Data Repository data (see https://biolincc.nhlbi.nih.gov/home/).","text_display":" NHLBI Data Repository data (see https://biolincc.nhlbi.nih.gov/home/).","confidence":0.99951171875,"confidence_rate":0.9999934880145616},{"cnt":[[305,1876],[1164,1876],[1164,1927],[305,1927]],"region":{"top_left_x":305,"top_left_y":1875,"width":860,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63dff01abee2425aa0f5771005d4ed76","type":"text","conversion_output":true,"text":"There are several principles underlying this policy:","text_display":"\n\nThere are several principles underlying this policy:","confidence":1,"confidence_rate":1},{"cnt":[[305,1964],[1729,1964],[1729,2013],[305,2013]],"region":{"top_left_x":305,"top_left_y":1963,"width":1425,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdd23fe3bc7c4b288813ef255c405a2b","type":"text","conversion_output":true,"text":"1. Research questions and hypotheses to be addressed using SPRINT Study data","text_display":"\n1. 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AAA: & Abdominal Aortic Aneurysm \\\\\n\\hline AASK: & African American Study of Kidney Disease and Hypertension \\\\\n\\hline ABI: & Ankle Brachial Index \\\\\n\\hline ACC: & American College of Cardiology \\\\\n\\hline ACCORD: & Action to Control \\\\\n\\hline & Cardiovascular Risk in \\\\\n\\hline ACE: & Angiotensin Converting \\\\\n\\hline & Enzyme \\\\\n\\hline ACR: & Albumin to Creatinine Ratio \\\\\n\\hline ACS: & Acute Coronary Syndrome \\\\\n\\hline AD: & Alzheimer's Disease \\\\\n\\hline AE: & Adverse Event \\\\\n\\hline AHA: & American Heart Association \\\\\n\\hline ALLHAT: & Antihypertensive and Lipid- \\\\\n\\hline & Lowering Treatment to Prevent \\\\\n\\hline & Heart Attack Trial \\\\\n\\hline ARB: & Angiotensis Receptor Blocker \\\\\n\\hline ARIC: & Atherosclerosis Risk in Communities \\\\\n\\hline AS: & Ancillary Science \\\\\n\\hline ASCOT: & Anglo-Scandinavian Cardiac Outcomes Trial \\\\\n\\hline BID: & Twice Daily \\\\\n\\hline BNT: & Boston Naming Test \\\\\n\\hline BP: & Blood Pressure \\\\\n\\hline BPH: & Benign Prostatic Hyperplasia \\\\\n\\hline CABG: & Coronary Artery Bypass \\\\\n\\hline & Grafting \\\\\n\\hline CAD: & Coronary Artery Disease \\\\\n\\hline CAMELOT: & Comparision of Amlodipine vs \\\\\n\\hline & Enalapril to Limit Occurrences \\\\\n\\hline CC: & Coordinating Center \\\\\n\\hline CCB: & Calcium Channel Blockers \\\\\n\\hline CCN: & Clinical Center Network \\\\\n\\hline CE: & Carotid Endarterectomy \\\\\n\\hline CEA: & Cost-Effectiveness Analysis \\\\\n\\hline CHD: & Coronary Heart Disease \\\\\n\\hline CHF: & Chronic Heart Failure \\\\\n\\hline CHS: & Cardiovascular Health Study \\\\\n\\hline CKD: & Chronic Kidney Disease \\\\\n\\hline Co-PI: & Co-Principal Investigator \\\\\n\\hline CPT: & Current Procedural \\\\\n\\hline CUA: & Cost-Utility Analysis \\\\\n\\hline CV: & Cardiovascular \\\\\n\\hline CVD: & Cardiovascular Disease \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{APPENDIX 1: Abbreviations Used}\n\\begin{tabular}{|l|l|}\n\\hline AAA: & Abdominal Aortic Aneurysm \\\\\n\\hline AASK: & African American Study of Kidney Disease and Hypertension \\\\\n\\hline ABI: & Ankle Brachial Index \\\\\n\\hline ACC: & American College of Cardiology \\\\\n\\hline ACCORD: & Action to Control \\\\\n\\hline & Cardiovascular Risk in \\\\\n\\hline ACE: & Angiotensin Converting \\\\\n\\hline & Enzyme \\\\\n\\hline ACR: & Albumin to Creatinine Ratio \\\\\n\\hline ACS: & Acute Coronary Syndrome \\\\\n\\hline AD: & Alzheimer's Disease \\\\\n\\hline AE: & Adverse Event \\\\\n\\hline AHA: & American Heart Association \\\\\n\\hline ALLHAT: & Antihypertensive and Lipid- \\\\\n\\hline & Lowering Treatment to Prevent \\\\\n\\hline & Heart Attack Trial \\\\\n\\hline ARB: & Angiotensis Receptor Blocker \\\\\n\\hline ARIC: & Atherosclerosis Risk in Communities 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(Note: ALLHAT used hospitalized angina rather than non-MI acute","confidence":0.979578093562916,"confidence_rate":0.999793688117334},{"cnt":[[245,795],[604,795],[604,840],[245,840]],"region":{"top_left_x":244,"top_left_y":794,"width":360,"height":47},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e01ccc2627284f77aaf3e9fda8aaeec1","type":"text","conversion_output":true,"text":"coronary syndrome.)","text_display":" coronary syndrome.)","confidence":1,"confidence_rate":1},{"cnt":[[245,881],[1867,881],[1867,930],[245,930]],"region":{"top_left_x":244,"top_left_y":880,"width":1623,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4f809c8e19a42c5a0dad423860110be","type":"text","conversion_output":true,"text":"This rate of \\(4.39 \\% / yr\\) provides a starting point for the estimation of event rates we will expect in","text_display":"\n\nThis rate of \\(4.39 \\% / yr\\) provides a starting point for the estimation of event rates we will expect in","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[1815,924],[1815,971],[245,971]],"region":{"top_left_x":244,"top_left_y":923,"width":1572,"height":49},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2018e3f37164444ac85db1a71204a6c","type":"text","conversion_output":true,"text":"SPRINT. Several factors can be considered which suggest that these rates should be either","text_display":" SPRINT. Several factors can be considered which suggest that these rates should be either","confidence":1,"confidence_rate":1},{"cnt":[[245,971],[1818,971],[1818,1016],[245,1016]],"region":{"top_left_x":244,"top_left_y":971,"width":1574,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afce725d575d4f1fbda109be9041645c","type":"text","conversion_output":true,"text":"increased or decreased. Factors arguing for an increased event rate include (1) SPRINT will","text_display":" increased or decreased. Factors arguing for an increased event rate include (1) SPRINT will","confidence":1,"confidence_rate":1},{"cnt":[[245,1014],[1867,1014],[1867,1059],[245,1059]],"region":{"top_left_x":244,"top_left_y":1014,"width":1623,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72a89d375ab94b1fa48eab84774a83ae","type":"text","conversion_output":true,"text":"have an older cohort of participants than did ALLHAT, (2) SPRINT will use the Framingham risk","text_display":" have an older cohort of participants than did ALLHAT, (2) SPRINT will use the Framingham risk","confidence":1,"confidence_rate":1},{"cnt":[[245,1057],[1779,1057],[1779,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1057,"width":1535,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20bcda078ea4442ba2803ffdbf070d57","type":"text","conversion_output":true,"text":"score of \\(\\geq 15 \\% 10\\)-year CVD risk as an inclusion criterion, and (3) inclusion of a substantial","text_display":" score of \\(\\geq 15 \\% 10\\)-year CVD risk as an inclusion criterion, and (3) inclusion of a substantial","confidence":0.96435546875,"confidence_rate":0.9996371127712621},{"cnt":[[245,1102],[1798,1102],[1798,1147],[245,1147]],"region":{"top_left_x":244,"top_left_y":1102,"width":1555,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35fcb849dcc64319990b46368bc47c6d","type":"text","conversion_output":true,"text":"group of participants with Stage 3 or Stage 4 CKD. Factors that are expected to reduce the","text_display":" group of participants with Stage 3 or Stage 4 CKD. Factors that are expected to reduce the","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,1145],[1871,1145],[1871,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1145,"width":1628,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a52ed05d77f4f74a333576b1efcfccd","type":"text","conversion_output":true,"text":"event rate include (1) the temporal trend towards a reduction in CVD event rates in the U.S. and","text_display":" event rate include (1) the temporal trend towards a reduction in CVD event rates in the U.S. and","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1841,1190],[1841,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1190,"width":1598,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"310bc20b5a1f4e85a5fcaa51b5e939d0","type":"text","conversion_output":true,"text":"(2) a more rigorous definition of non-Ml acute coronary syndrome that will be used in SPRINT.","text_display":" (2) a more rigorous definition of non-Ml acute coronary syndrome that will be used in SPRINT.","confidence":0.64404296875,"confidence_rate":0.9955203714234886},{"cnt":[[245,1233],[1790,1233],[1790,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1233,"width":1546,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14fc888655f64a83955d78019c1f1456","type":"text","conversion_output":true,"text":"It is difficult to precisely estimate the impact that these five factors will have on the SPRINT","text_display":" It is difficult to precisely estimate the impact that these five factors will have on the SPRINT","confidence":1,"confidence_rate":1},{"cnt":[[245,1278],[434,1278],[434,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1278,"width":190,"height":39},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b23a592a58644345b9e05fabbce4efc9","type":"text","conversion_output":true,"text":"event rate.","text_display":" event rate.","confidence":1,"confidence_rate":1},{"cnt":[[245,1366],[1837,1366],[1837,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1366,"width":1593,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7ca0b5b78ac462192f80df492cfc190","type":"text","conversion_output":true,"text":"In ALLHAT, event rates increased substantially with age. The event rate for participants 70 to","text_display":"\n\nIn ALLHAT, event rates increased substantially with age. The event rate for participants 70 to","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1815,1409],[1815,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1409,"width":1572,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55cbd7ea883548dd9b1de907cf9b884c","type":"text","conversion_output":true,"text":"\\(<75\\) years old was \\(5.19 \\% / yr\\); for participants \\(\\geq 75\\) years old, the event rate was \\(6.99 \\% / yr\\). In","text_display":" \\(<75\\) years old was \\(5.19 \\% / yr\\); for participants \\(\\geq 75\\) years old, the event rate was \\(6.99 \\% / yr\\). In","confidence":0.9742294490570202,"confidence_rate":0.9997669161941245},{"cnt":[[245,1452],[1828,1452],[1828,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1452,"width":1585,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cc6245bdb724ff5ac5f0ea3899a211e","type":"text","conversion_output":true,"text":"ALLHAT \\(17.7 \\%\\) of the participants were 70 to \\(<75\\) years old, while \\(18.5 \\%\\) were \\(\\geq 75\\) years old.","text_display":" ALLHAT \\(17.7 \\%\\) of the participants were 70 to \\(<75\\) years old, while \\(18.5 \\%\\) were \\(\\geq 75\\) years old.","confidence":0.9853763580322266,"confidence_rate":0.9998660851363524},{"cnt":[[245,1497],[1762,1497],[1762,1543],[245,1543]],"region":{"top_left_x":244,"top_left_y":1497,"width":1518,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64296ed54acf496b918dbef4bbdfe8c5","type":"text","conversion_output":true,"text":"We expect that participants in these age categories will represent a greater fraction of the","text_display":" We expect that participants in these age categories will represent a greater fraction of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1540],[1818,1540],[1818,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1540,"width":1574,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89a38266c2f64375bf17b6f45a3236ef","type":"text","conversion_output":true,"text":"SPRINT cohort. Approximately \\(50 \\%\\) ( 4625 participants) are expected to be at least 70 years","text_display":" SPRINT cohort. Approximately \\(50 \\%\\) ( 4625 participants) are expected to be at least 70 years","confidence":1,"confidence_rate":1},{"cnt":[[245,1586],[1811,1586],[1811,1631],[245,1631]],"region":{"top_left_x":244,"top_left_y":1585,"width":1568,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"022ff9166ab7417ab679a9bc4118cf02","type":"text","conversion_output":true,"text":"old, while \\(35.1 \\%\\) ( 3250 participants) are expected to be \\(\\geq 75\\) years old. This will likely yield a","text_display":" old, while \\(35.1 \\%\\) ( 3250 participants) are expected to be \\(\\geq 75\\) years old. This will likely yield a","confidence":0.99755859375,"confidence_rate":0.9999777785074303},{"cnt":[[245,1629],[1130,1629],[1130,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1628,"width":887,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d543fb66bb3049a5a511639131fed741","type":"text","conversion_output":true,"text":"higher event rate in SPRINT, compared to ALLHAT.","text_display":" higher event rate in SPRINT, compared to ALLHAT.","confidence":1,"confidence_rate":1},{"cnt":[[245,1714],[1846,1714],[1846,1764],[245,1764]],"region":{"top_left_x":244,"top_left_y":1714,"width":1602,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a660bb81f8241da801a3ead749b075b","type":"text","conversion_output":true,"text":"The event rate in ALLHAT among participants with 10 -year Framingham risk \\(\\geq 15 \\%\\) at baseline","text_display":"\n\nThe event rate in ALLHAT among participants with 10 -year Framingham risk \\(\\geq 15 \\%\\) at baseline","confidence":0.994140625,"confidence_rate":0.9999418174502049},{"cnt":[[245,1762],[1846,1762],[1846,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1761,"width":1602,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6064144e8039446f958bfc1fda079463","type":"text","conversion_output":true,"text":"was \\(4.67 \\% / yr\\). Our including people with \\(\\geq 15 \\% 10\\)-year risk will help to ensure a higher event","text_display":" was \\(4.67 \\% / yr\\). Our including people with \\(\\geq 15 \\% 10\\)-year risk will help to ensure a higher event","confidence":0.9921996551565826,"confidence_rate":0.9999268164474899},{"cnt":[[245,1805],[329,1805],[329,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1804,"width":85,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac7ec347ef4e405f864d198bf6935629","type":"text","conversion_output":true,"text":"rate.","text_display":" rate.","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1850,1886],[1850,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1886,"width":1606,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58aef247b5e44fcaa7c5a7a05781ed6d","type":"text","conversion_output":true,"text":"We expect that 4300 SPRINT participants will have eGFR 20 to \\(<60 mL / min / 1.73 m^{2}\\) with equal","text_display":"\n\nWe expect that 4300 SPRINT participants will have eGFR 20 to \\(<60 mL / min / 1.73 m^{2}\\) with equal","confidence":0.99853515625,"confidence_rate":0.999987577045958},{"cnt":[[245,1931],[1803,1931],[1803,1983],[245,1983]],"region":{"top_left_x":244,"top_left_y":1931,"width":1559,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e9567c1f8ae40a5a6153fd6fd2cff2f","type":"text","conversion_output":true,"text":"numbers above and below \\(45 mL / min / 1.73 m^{2}\\). In ALLHAT, the event rate was \\(5.89 \\% / yr\\) for","text_display":" numbers above and below \\(45 mL / min / 1.73 m^{2}\\). In ALLHAT, the event rate was \\(5.89 \\% / yr\\) for","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,1977],[1878,1977],[1878,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1976,"width":1634,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22f4d7355ebd4dcfb680cb6185dbe346","type":"text","conversion_output":true,"text":"those with eGFR 45 to \\(<60 mL / min / 1.73 m^{2}\\). Among those \\(<45\\), the event rate was \\(8.24 \\% / yr\\). In","text_display":" those with eGFR 45 to \\(<60 mL / min / 1.73 m^{2}\\). Among those \\(<45\\), the event rate was \\(8.24 \\% / yr\\). In","confidence":0.9417630021926016,"confidence_rate":0.9995276578399663},{"cnt":[[245,2020],[1755,2020],[1755,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2019,"width":1512,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b34307f4d81b4df29c6abe2144875999","type":"text","conversion_output":true,"text":"ALLHAT, \\(18.6 \\%\\) had eGFR \\(<60 mL / min / 1.73 m^{2}\\) as compared with the expected \\(46.7 \\%\\) in","text_display":" ALLHAT, \\(18.6 \\%\\) had eGFR \\(<60 mL / min / 1.73 m^{2}\\) as compared with the expected \\(46.7 \\%\\) in","confidence":0.9931671619415283,"confidence_rate":0.9999365178596985},{"cnt":[[245,2067],[1800,2067],[1800,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2066,"width":1557,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"486c43a3d8e8439cb126c84f60d820db","type":"text","conversion_output":true,"text":"SPRINT. Increasing the numbers of participants with CKD in SPRINT will help increase the","text_display":" SPRINT. Increasing the numbers of participants with CKD in SPRINT will help increase the","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[453,2110],[453,2153],[245,2153]],"region":{"top_left_x":244,"top_left_y":2109,"width":210,"height":44},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"800c4d7386f6433f9ee047bbb71f2d97","type":"text","conversion_output":true,"text":"event rates.","text_display":" event rates.","confidence":1,"confidence_rate":1},{"cnt":[[245,2200],[1858,2200],[1858,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2200,"width":1615,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0117bdb1ded1437897580976735a77ec","type":"text","conversion_output":true,"text":"We compared ALLHAT participants with diabetes to participants in the ACCORD BP trial (all of","text_display":"\n\nWe compared ALLHAT participants with diabetes to participants in the ACCORD BP trial (all of","confidence":0.99853515625,"confidence_rate":0.9999848875607663},{"cnt":[[245,2243],[1837,2243],[1837,2288],[245,2288]],"region":{"top_left_x":244,"top_left_y":2242,"width":1593,"height":47},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c72d16a0bdc44fa891b82616c7af609","type":"text","conversion_output":true,"text":"whom have diabetes) using outcome variables that are as similar as possible. In ALLHAT the","text_display":" whom have diabetes) using outcome variables that are as similar as possible. In ALLHAT the","confidence":1,"confidence_rate":1},{"cnt":[[245,2286],[1772,2286],[1772,2333],[245,2333]],"region":{"top_left_x":244,"top_left_y":2285,"width":1529,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c83e0b48beb04c148dd0f19910be104e","type":"text","conversion_output":true,"text":"event rate was \\(5.90 \\% / yr\\). The corresponding event rate in ACCORD was \\(3.43 \\% / yr\\). The","text_display":" event rate was \\(5.90 \\% / yr\\). The corresponding event rate in ACCORD was \\(3.43 \\% / yr\\). The","confidence":0.7065610885620117,"confidence_rate":0.9965325693291193},{"cnt":[[245,2331],[1772,2331],[1772,2378],[245,2378]],"region":{"top_left_x":244,"top_left_y":2331,"width":1529,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5222da7fa5704b0eb96e534250f5799d","type":"text","conversion_output":true,"text":"reduction in event rates between ALLHAT and ACCORD could be due to a temporal trend","text_display":" reduction in event rates between ALLHAT and ACCORD could be due to a temporal trend","confidence":1,"confidence_rate":1},{"cnt":[[245,2374],[1824,2374],[1824,2421],[245,2421]],"region":{"top_left_x":244,"top_left_y":2374,"width":1581,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db312d9365b1480c81049559953a619a","type":"text","conversion_output":true,"text":"(ALLHAT was 1994-1999, ACCORD was 2001-2009), because ALLHAT participants were","text_display":" (ALLHAT was 1994-1999, ACCORD was 2001-2009), because ALLHAT participants were","confidence":0.99951171875,"confidence_rate":0.999994115673962},{"cnt":[[245,2419],[1575,2419],[1575,2466],[245,2466]],"region":{"top_left_x":244,"top_left_y":2419,"width":1331,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bc6da45cf8549a687535814eca7f2ca","type":"text","conversion_output":true,"text":"older (mean 67 years) than ACCORD (mean 62.2 years), or for other reasons.","text_display":" older (mean 67 years) than ACCORD (mean 62.2 years), or for other reasons.","confidence":1,"confidence_rate":1},{"cnt":[[305,2587],[492,2587],[492,2623],[305,2623]],"region":{"top_left_x":305,"top_left_y":2586,"width":187,"height":38},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f2e3d9a0b6c46fc944172fd24f57acb","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1031,2587],[1096,2587],[1096,2625],[1031,2625]],"region":{"top_left_x":1031,"top_left_y":2586,"width":65,"height":40},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d305c20a6ba4827a56a4138688e70c9","type":"page_info","conversion_output":false,"text":"104","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2587],[1815,2587],[1815,2625],[1521,2625]],"region":{"top_left_x":1521,"top_left_y":2586,"width":295,"height":40},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d724863a1fb449fa7d2c62c9843dece","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-107","page":107,"lines":[{"cnt":[[245,296],[1865,296],[1865,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1621,"height":46},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bec2a153d832473bb5ae59025caeac4a","type":"text","conversion_output":true,"text":"Exactly how we should use the ALLHAT data to estimate the event rates for SPRINT is unclear.","text_display":"\n\nExactly how we should use the ALLHAT data to estimate the event rates for SPRINT is unclear.","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1828,339],[1828,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1585,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66d6dc82386c453696eda32851fdcf8c","type":"text","conversion_output":true,"text":"Since the rates in ACCORD were approximately half of those in ALLHAT, for the purposes of","text_display":" Since the rates in ACCORD were approximately half of those in ALLHAT, for the purposes of","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,385],[1740,385],[1740,432],[245,432]],"region":{"top_left_x":244,"top_left_y":384,"width":1497,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd5d4bc412e34c94966d15fad5473eac","type":"text","conversion_output":true,"text":"power we will assume that the SPRINT rates will also be half of the ALLHAT rates. This","text_display":" power we will assume that the SPRINT rates will also be half of the ALLHAT rates. This","confidence":1,"confidence_rate":1},{"cnt":[[245,430],[1835,430],[1835,475],[245,475]],"region":{"top_left_x":244,"top_left_y":429,"width":1591,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3a45a821d1f486084f5d69b5f6aa98e","type":"text","conversion_output":true,"text":"assumption balances the possibility of a further temporal trend in event rate reduction with the","text_display":" assumption balances the possibility of a further temporal trend in event rate reduction with the","confidence":1,"confidence_rate":1},{"cnt":[[245,473],[1824,473],[1824,518],[245,518]],"region":{"top_left_x":244,"top_left_y":472,"width":1581,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf2d1fbcc928448b971f653ee659127e","type":"text","conversion_output":true,"text":"fact that participants recruited for SPRINT will be older, have lower kidney function, and have","text_display":" fact that participants recruited for SPRINT will be older, have lower kidney function, and have","confidence":1,"confidence_rate":1},{"cnt":[[245,516],[1846,516],[1846,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":1602,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c8d77576588449db0bec8c580d400e7","type":"text","conversion_output":true,"text":"greater Framingham CVD risk scores than those recruited in either ALLHAT or ACCORD. We","text_display":" greater Framingham CVD risk scores than those recruited in either ALLHAT or ACCORD. We","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1841,559],[1841,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1598,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"deb35a5493634662b4d7d7c6dab8453f","type":"text","conversion_output":true,"text":"expect that this may be slightly conservative. Thus, we assume that the event rate in SPRINT","text_display":" expect that this may be slightly conservative. Thus, we assume that the event rate in SPRINT","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[245,602],[1764,604],[1764,651]],"region":{"top_left_x":244,"top_left_y":601,"width":1520,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56c43480f2f7444183a2c37fe9f85694","type":"text","conversion_output":true,"text":"will be approximately \\(2.2 \\% / yr\\) for the composite outcome including non-fatal MI, non-fatal","text_display":" will be approximately \\(2.2 \\% / yr\\) for the composite outcome including non-fatal MI, non-fatal","confidence":1,"confidence_rate":1},{"cnt":[[245,647],[1833,647],[1833,694],[245,694]],"region":{"top_left_x":244,"top_left_y":646,"width":1589,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c5d854a35c1490c86de071905c06f64","type":"text","conversion_output":true,"text":"stroke, cardiovascular death, hospitalized heart failure, and non-Ml acute coronary syndrome.","text_display":" stroke, cardiovascular death, hospitalized heart failure, and non-Ml acute coronary syndrome.","confidence":0.9990236759185791,"confidence_rate":0.9999900326925697},{"cnt":[[245,735],[1772,735],[1772,780],[245,780]],"region":{"top_left_x":244,"top_left_y":734,"width":1529,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df4d8b914f28479cbd44c69dc94f3057","type":"text","conversion_output":true,"text":"We have assumed a 2 -year uniform accrual period, 3 years 10 months minimum follow-up","text_display":"\n\nWe have assumed a 2 -year uniform accrual period, 3 years 10 months minimum follow-up","confidence":0.99169921875,"confidence_rate":0.9999158073365324},{"cnt":[[245,778],[1869,778],[1869,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1626,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fb68dc5667f4c439c0813321f6b42ce","type":"text","conversion_output":true,"text":"(assumes that closeout visits occur uniformly over a 4 -month period), and a 2 sided significance","text_display":" (assumes that closeout visits occur uniformly over a 4 -month period), and a 2 sided significance","confidence":0.682283878326416,"confidence_rate":0.996466355624976},{"cnt":[[245,821],[1751,821],[1751,870],[245,870]],"region":{"top_left_x":244,"top_left_y":820,"width":1507,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a14fa3df30a474fbdce080255848e29","type":"text","conversion_output":true,"text":"level of 0.05 . The effect size for the primary outcome is assumed to be \\(20 \\%\\) in the entire","text_display":" level of 0.05 . The effect size for the primary outcome is assumed to be \\(20 \\%\\) in the entire","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[245,868],[1790,868],[1790,913],[245,913]],"region":{"top_left_x":244,"top_left_y":867,"width":1546,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6637da6bdc804aef93e2c5a4991a13b7","type":"text","conversion_output":true,"text":"sample and the CKD subsample, and \\(25 \\%\\) in the Senior subsample. Loss to follow-up and","text_display":" sample and the CKD subsample, and \\(25 \\%\\) in the Senior subsample. Loss to follow-up and","confidence":0.99853515625,"confidence_rate":0.9999840662390905},{"cnt":[[245,911],[1828,911],[1828,956],[245,956]],"region":{"top_left_x":244,"top_left_y":910,"width":1585,"height":47},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab327deace3147d991d0c2d7df83c55d","type":"text","conversion_output":true,"text":"events are assumed to follow an exponential model. We expect that the annual rate of loss to","text_display":" events are assumed to follow an exponential model. We expect that the annual rate of loss to","confidence":1,"confidence_rate":1},{"cnt":[[245,954],[1734,954],[1734,1001],[245,1001]],"region":{"top_left_x":244,"top_left_y":953,"width":1490,"height":49},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd0457a14c1846efa2a9270da976ac22","type":"text","conversion_output":true,"text":"follow-up will be approximately \\(2 \\%\\) but have included rates up to \\(3 \\%\\) to be conservative.","text_display":" follow-up will be approximately \\(2 \\%\\) but have included rates up to \\(3 \\%\\) to be conservative.","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,997],[1846,997],[1846,1044],[245,1044]],"region":{"top_left_x":244,"top_left_y":996,"width":1602,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dfb107457cc47afbcc9f56252da8418","type":"text","conversion_output":true,"text":"Calculations made using two methods (Lachin and Foulkes, 1986;Lakatos, 1988) were similar.","text_display":" Calculations made using two methods (Lachin and Foulkes, 1986;Lakatos, 1988) were similar.","confidence":1,"confidence_rate":1},{"cnt":[[245,1042],[1846,1042],[1846,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1041,"width":1602,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0db76ce982b44de0bd097457b2696a17","type":"text","conversion_output":true,"text":"Power for the primary outcome for a range of event rates and annual loss rates is presented in","text_display":" Power for the primary outcome for a range of event rates and annual loss rates is presented in","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[986,1087],[986,1128],[245,1128]],"region":{"top_left_x":244,"top_left_y":1087,"width":743,"height":41},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"830a61cf5bc844548f6dc55a9af6e33e","type":"text","conversion_output":true,"text":"Table 1 for the assumed effect size of \\(20 \\%\\).","text_display":" Table 1 for the assumed effect size of \\(20 \\%\\).","confidence":0.77197265625,"confidence_rate":0.9953054874877901},{"cnt":[[541,1169],[1583,1169],[1583,1540],[541,1540]],"region":{"top_left_x":541,"top_left_y":1168,"width":1043,"height":373},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04cda33dce8a4a8fb3df82820032c5b1","type":"table","conversion_output":true,"text":"\\begin{tabular}{|}\n\\hline Table 1. Power for the primary outcome in entire sample of \\\\\n9250 participants for a 20\\% effect (Hazard Ratio of 0.8). \\\\\n\\hline \\begin{tabular}{c} \nAnnual \\\\\nLoss \\\\\nRate (\\%/yr)\n\\end{tabular} & \\multicolumn{5}{|c|}{ Annual Standard Arm Event Rate (\\%/yr) } \\\\\n\\cline { 2 - 6 } & 1.8 & 2.0 & 2.2 & 2.4 & 2.6 \\\\\n\\hline 1 & 82.9 & 86.5 & 89.4 & 91.7 & 93.5 \\\\\n\\hline 2 & 82.0 & 85.7 & 88.7 & 91.0 & 93.0 \\\\\n\\hline 3 & 81.1 & 84.8 & 87.9 & 90.4 & 92.4 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|}\n\\hline Table 1. Power for the primary outcome in entire sample of \\\\\n9250 participants for a 20\\% effect (Hazard Ratio of 0.8). \\\\\n\\hline \\begin{tabular}{c} \nAnnual \\\\\nLoss \\\\\nRate (\\%/yr)\n\\end{tabular} & \\multicolumn{5}{|c|}{ Annual Standard Arm Event Rate (\\%/yr) } \\\\\n\\cline { 2 - 6 } & 1.8 & 2.0 & 2.2 & 2.4 & 2.6 \\\\\n\\hline 1 & 82.9 & 86.5 & 89.4 & 91.7 & 93.5 \\\\\n\\hline 2 & 82.0 & 85.7 & 88.7 & 91.0 & 93.0 \\\\\n\\hline 3 & 81.1 & 84.8 & 87.9 & 90.4 & 92.4 \\\\\n\\hline\n\\end{tabular}","confidence":0.3489353579127802,"confidence_rate":0.9974539281216391},{"cnt":[[245,1577],[1803,1577],[1803,1626],[245,1626]],"region":{"top_left_x":244,"top_left_y":1576,"width":1559,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2d84a5568164d39be7ac9ec68d51f9f","type":"text","conversion_output":true,"text":"In ALLHAT the event rates were \\(5.89 \\% / yr\\) and \\(8.24 \\% / yr\\) for people whose eGFR was 45 to","text_display":"\n\nIn ALLHAT the event rates were \\(5.89 \\% / yr\\) and \\(8.24 \\% / yr\\) for people whose eGFR was 45 to","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,1618],[1775,1618],[1775,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1617,"width":1531,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"040a46d4c2a74e64ae318ad10fc5a6c1","type":"text","conversion_output":true,"text":"\\(<60\\) or \\(<45 mL / min / 1.73 m^{2}\\). We will assume that the event rate for the primary outcome in","text_display":" \\(<60\\) or \\(<45 mL / min / 1.73 m^{2}\\). We will assume that the event rate for the primary outcome in","confidence":0.943359375,"confidence_rate":0.9994700679964366},{"cnt":[[245,1663],[1755,1663],[1755,1712],[245,1712]],"region":{"top_left_x":244,"top_left_y":1662,"width":1512,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6724f40f58794b6baadbdf5908678edf","type":"text","conversion_output":true,"text":"SPRINT will be \\(4 \\% / yr\\) among participants with eGFR \\(<60 mL / min / 1.73 m^{2}\\). Power for the","text_display":" SPRINT will be \\(4 \\% / yr\\) among participants with eGFR \\(<60 mL / min / 1.73 m^{2}\\). Power for the","confidence":1,"confidence_rate":1},{"cnt":[[245,1710],[1828,1710],[1828,1757],[245,1757]],"region":{"top_left_x":244,"top_left_y":1710,"width":1585,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23d000ed471246daa4fa529b179babff","type":"text","conversion_output":true,"text":"primary outcome among SPRINT participants with CKD for a range of event rates and annual","text_display":" primary outcome among SPRINT participants with CKD for a range of event rates and annual","confidence":1,"confidence_rate":1},{"cnt":[[245,1753],[1420,1753],[1420,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1753,"width":1177,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb0891841ad249d9b382eaa6a77c7f49","type":"text","conversion_output":true,"text":"loss rates is presented in Table 2 for the assumed effect size of \\(20 \\%\\).","text_display":" loss rates is presented in Table 2 for the assumed effect size of \\(20 \\%\\).","confidence":0.6179165840148926,"confidence_rate":0.9941464454453732},{"cnt":[[606,1835],[1519,1835],[1519,2297],[606,2297]],"region":{"top_left_x":605,"top_left_y":1834,"width":914,"height":463},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d39422ae760c4211826300849698a877","type":"table","conversion_output":true,"text":"\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline \\multicolumn{6}{|c|}{\\begin{tabular}{c} \nTable 2. Power for the primary outcome in CKD \\\\\nsubsample (eGFR \\(<60 mL / min / 1.73 m^{2}\\) ) of 4300 \\\\\nsarticipants for a \\(20 \\%\\) effect (Hazard Ratio of 0.8 ). \\\\\n\\hline \\begin{tabular}{c} \nAnnual \\\\\nLoss \\\\\nRate \\\\\n(\\%/yr)\n\\end{tabular} \\\\\n\\cline { 2 - 6 } \\\\\n\\hline 1\n\\end{tabular}} \\\\\n\\cline { 2 - 6 } & 3.5 & 3.75 & 4.0 & 4.25 & 4.5 \\\\\n\\hline 2 & 76.9 & 80.5 & 82.7 & 84.8 & 86.6 \\\\\n\\hline 3 & 75.9 & 78.6 & 81.9 & 83.9 & 85.8 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline \\multicolumn{6}{|c|}{\\begin{tabular}{c} \nTable 2. Power for the primary outcome in CKD \\\\\nsubsample (eGFR \\(<60 mL / min / 1.73 m^{2}\\) ) of 4300 \\\\\nsarticipants for a \\(20 \\%\\) effect (Hazard Ratio of 0.8 ). \\\\\n\\hline \\begin{tabular}{c} \nAnnual \\\\\nLoss \\\\\nRate \\\\\n(\\%/yr)\n\\end{tabular} \\\\\n\\cline { 2 - 6 } \\\\\n\\hline 1\n\\end{tabular}} \\\\\n\\cline { 2 - 6 } & 3.5 & 3.75 & 4.0 & 4.25 & 4.5 \\\\\n\\hline 2 & 76.9 & 80.5 & 82.7 & 84.8 & 86.6 \\\\\n\\hline 3 & 75.9 & 78.6 & 81.9 & 83.9 & 85.8 \\\\\n\\hline\n\\end{tabular}","confidence":0.01748463130219523,"confidence_rate":0.9906554585113321},{"cnt":[[245,2380],[1876,2380],[1876,2428],[245,2428]],"region":{"top_left_x":244,"top_left_y":2380,"width":1632,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef45b414022a4f24a09a31830079a7be","type":"text","conversion_output":true,"text":"In ALLHAT, the event rate was \\(6.99 \\% / yr\\) among participants at least 75 years old. Applying the","text_display":"\n\nIn ALLHAT, the event rate was \\(6.99 \\% / yr\\) among participants at least 75 years old. Applying the","confidence":0.9990236759185791,"confidence_rate":0.999990871060396},{"cnt":[[245,2426],[1815,2426],[1815,2471],[245,2471]],"region":{"top_left_x":244,"top_left_y":2425,"width":1572,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4514d4b769ed4c2ea78a58bac51d0379","type":"text","conversion_output":true,"text":"same halving as was done above for the entire sample, we will assume that the event rate in","text_display":" same halving as was done above for the entire sample, we will assume that the event rate in","confidence":1,"confidence_rate":1},{"cnt":[[305,2587],[492,2587],[492,2623],[305,2623]],"region":{"top_left_x":305,"top_left_y":2586,"width":187,"height":38},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5fa177f18964fdd8aba2660edae3c28","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1031,2587],[1098,2587],[1098,2625],[1031,2625]],"region":{"top_left_x":1031,"top_left_y":2586,"width":67,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cfa9e68392c4846a008ba5b9015fbbc","type":"page_info","conversion_output":false,"text":"105","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2587],[1815,2587],[1815,2628],[1521,2628]],"region":{"top_left_x":1521,"top_left_y":2586,"width":295,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f2b3be32ace4ecc88c0f5bb43ddc7e3","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-108","page":108,"lines":[{"cnt":[[245,249],[1833,249],[1833,299],[245,299]],"region":{"top_left_x":244,"top_left_y":249,"width":1589,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0660dc86135e491ea81659872e227af5","type":"text","conversion_output":true,"text":"SPRINT will be \\(3.5 \\%\\) /year among participants \\(\\geq 75\\) years old. Power for the primary outcome","text_display":"\n\nSPRINT will be \\(3.5 \\%\\) /year among participants \\(\\geq 75\\) years old. Power for the primary outcome","confidence":0.99853515625,"confidence_rate":0.9999853409306202},{"cnt":[[243,294],[1854,294],[1854,342],[243,342]],"region":{"top_left_x":242,"top_left_y":294,"width":1613,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"043b19d310324c399059ae9f0c903c8e","type":"text","conversion_output":true,"text":"among SPRINT Senior for a range of event rates and annual loss rates is presented in Table 3","text_display":" among SPRINT Senior for a range of event rates and annual loss rates is presented in Table 3","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[243,339],[853,339],[853,382],[243,382]],"region":{"top_left_x":242,"top_left_y":339,"width":611,"height":44},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3db74736df354595a7076931202d78a9","type":"text","conversion_output":true,"text":"for the assumed effect size of \\(25 \\%\\).","text_display":" for the assumed effect size of \\(25 \\%\\).","confidence":0.99853515625,"confidence_rate":0.9999666842440162},{"cnt":[[455,466],[1669,466],[1669,924],[455,924]],"region":{"top_left_x":455,"top_left_y":466,"width":1215,"height":458},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bda9867aeda4d5ab424511d121203b9","type":"table","conversion_output":true,"text":"\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline \\multicolumn{6}{|c|}{\\begin{tabular}{c} \nTable 3. Power for the primary outcome in Senior subsample ( \\(\\geq 75\\) \\\\\nyears old) of 3250 participants for a \\(25 \\%\\) effect (Hazard Ratio of \\\\\n0.75 ).\n\\end{tabular}} \\\\\n\\hline \\multicolumn{6}{|c|}{\\begin{tabular}{c} \nAnnual Standard Arm Event Rate (\\%/yr) \\\\\nAnnual \\\\\nLoss \\\\\nRate \\\\\n\\((\\% / yr )\\)\n\\end{tabular}} \\\\\n\\cline { 2 - 6 } & 3.0 & 3.25 & 3.5 & 3.75 & 4.0 \\\\\n\\hline 1 & 79.9 & 82.8 & 85.3 & 87.5 & 89.4 \\\\\n\\hline 2 & 79.0 & 81.9 & 84.5 & 86.7 & 88.6 \\\\\n\\hline 3 & 78.0 & 81.0 & 83.6 & 85.9 & 87.9 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|c|c|c|c|c|c|}\n\\hline \\multicolumn{6}{|c|}{\\begin{tabular}{c} \nTable 3. Power for the primary outcome in Senior subsample ( \\(\\geq 75\\) \\\\\nyears old) of 3250 participants for a \\(25 \\%\\) effect (Hazard Ratio of \\\\\n0.75 ).\n\\end{tabular}} \\\\\n\\hline \\multicolumn{6}{|c|}{\\begin{tabular}{c} \nAnnual Standard Arm Event Rate (\\%/yr) \\\\\nAnnual \\\\\nLoss \\\\\nRate \\\\\n\\((\\% / yr )\\)\n\\end{tabular}} \\\\\n\\cline { 2 - 6 } & 3.0 & 3.25 & 3.5 & 3.75 & 4.0 \\\\\n\\hline 1 & 79.9 & 82.8 & 85.3 & 87.5 & 89.4 \\\\\n\\hline 2 & 79.0 & 81.9 & 84.5 & 86.7 & 88.6 \\\\\n\\hline 3 & 78.0 & 81.0 & 83.6 & 85.9 & 87.9 \\\\\n\\hline\n\\end{tabular}","confidence":0.06186217004644518,"confidence_rate":0.994302031630003},{"cnt":[[305,2587],[492,2587],[492,2623],[305,2623]],"region":{"top_left_x":305,"top_left_y":2586,"width":187,"height":38},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39eebca574ec41b8bc7c260f16932fff","type":"page_info","conversion_output":false,"text":"Version 4.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1031,2587],[1096,2587],[1096,2625],[1031,2625]],"region":{"top_left_x":1031,"top_left_y":2586,"width":65,"height":40},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8099ceffcc1046eeb506e724c58788d8","type":"page_info","conversion_output":false,"text":"106","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1521,2587],[1815,2587],[1815,2628],[1521,2628]],"region":{"top_left_x":1521,"top_left_y":2586,"width":295,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba31fc51bf324bf9872bdc906aa80826","type":"page_info","conversion_output":false,"text":"November 1, 2012","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0af9d5ab-703e-4ab1-bbab-51f070cc030a-109","page":109,"lines":[{"cnt":[[241,335],[1745,335],[1745,436],[241,436]],"region":{"top_left_x":240,"top_left_y":335,"width":1505,"height":102},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68eb2f2071e74ba399e96063e570ef8f","type":"section_header","conversion_output":false,"children_ids":["18f4382f33f144d893a3ad9470b6b2f9","aad970fccbe74d89927f2873e98f9163"],"text":"","text_display":""},{"cnt":[[245,339],[1738,339],[1738,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":1495,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18f4382f33f144d893a3ad9470b6b2f9","type":"text","conversion_output":true,"parent_id":"68eb2f2071e74ba399e96063e570ef8f","text":"APPENDIX 3: Computational Details and Sensitivity Analyses for the MIND","text_display":"\n\n\\section*{APPENDIX 3: Computational Details and Sensitivity Analyses for the MIND","confidence":0.9990236759185791,"confidence_rate":0.9999871474379078},{"cnt":[[245,391],[449,391],[449,432],[245,432]],"region":{"top_left_x":244,"top_left_y":391,"width":206,"height":41},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aad970fccbe74d89927f2873e98f9163","type":"text","conversion_output":true,"parent_id":"68eb2f2071e74ba399e96063e570ef8f","text":"outcomes","text_display":" outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[1869,477],[1869,524],[245,524]],"region":{"top_left_x":244,"top_left_y":476,"width":1626,"height":49},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a3169f40c7b4fa3899dd2a132e9983b","type":"text","conversion_output":true,"text":"Dementia. The primary outcome for SPRINT MIND is all-cause dementia. Table 1 summarizes","text_display":"\n\nDementia. The primary outcome for SPRINT MIND is all-cause dementia. Table 1 summarizes","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1781,524],[1781,569],[245,569]],"region":{"top_left_x":244,"top_left_y":524,"width":1538,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80d1311f3b5b4620acee61ecd268c4fe","type":"text","conversion_output":true,"text":"dementia rates from HYVET-COG (Peters, 2008), the Ginkgo Evaluation of Memory Study","text_display":" dementia rates from HYVET-COG (Peters, 2008), the Ginkgo Evaluation of Memory Study","confidence":1,"confidence_rate":1},{"cnt":[[245,567],[1828,567],[1828,612],[245,612]],"region":{"top_left_x":244,"top_left_y":567,"width":1585,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae1c009ca9fa4e1daad8bc9f09740c40","type":"text","conversion_output":true,"text":"(GEMS) (DeKosky, 2008), the Cardiovascular Health Study (CHS) (Fitzpatrick, 2004) and the","text_display":" (GEMS) (DeKosky, 2008), the Cardiovascular Health Study (CHS) (Fitzpatrick, 2004) and the","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,610],[1835,610],[1835,655],[245,655]],"region":{"top_left_x":244,"top_left_y":610,"width":1591,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57fc7e47bb834d69aa34e01ade4a3d43","type":"text","conversion_output":true,"text":"Women's Health Initiative Memory Study (WHIMS) (Shumaker, 2004). In HYVET-COG, there","text_display":" Women's Health Initiative Memory Study (WHIMS) (Shumaker, 2004). In HYVET-COG, there","confidence":1,"confidence_rate":1},{"cnt":[[245,655],[1772,655],[1772,698],[245,698]],"region":{"top_left_x":244,"top_left_y":655,"width":1529,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c2d2197ee574467b3c5a344d0524acd","type":"text","conversion_output":true,"text":"was a \\(14 \\%\\) non-significant decline in dementia. Overall annual dementia rate varied from","text_display":" was a \\(14 \\%\\) non-significant decline in dementia. Overall annual dementia rate varied from","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[245,698],[1807,698],[1807,746],[245,746]],"region":{"top_left_x":244,"top_left_y":698,"width":1563,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49344d4bfe1845c7b10bb424fa9c820e","type":"text","conversion_output":true,"text":"\\(0.13 \\%\\) to \\(3.86 \\%\\). The Women's Health Initiative Memory Study (WHIMS) (Shumaker, 2004)","text_display":" \\(0.13 \\%\\) to \\(3.86 \\%\\). The Women's Health Initiative Memory Study (WHIMS) (Shumaker, 2004)","confidence":1,"confidence_rate":1},{"cnt":[[245,743],[1779,743],[1779,788],[245,788]],"region":{"top_left_x":244,"top_left_y":743,"width":1535,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4560c8f94a894c2586c50d3a84cae875","type":"text","conversion_output":true,"text":"recruited women 65 and older with a mean age of 69 in two hormone replacement therapy","text_display":" recruited women 65 and older with a mean age of 69 in two hormone replacement therapy","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1833,786],[1833,831],[245,831]],"region":{"top_left_x":244,"top_left_y":786,"width":1589,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8cf19709da0483cb41f7ef60afac0d1","type":"text","conversion_output":true,"text":"interventions. Both trials were stopped early because of unexpected increased health risks in","text_display":" interventions. Both trials were stopped early because of unexpected increased health risks in","confidence":1,"confidence_rate":1},{"cnt":[[245,829],[1858,829],[1858,879],[245,879]],"region":{"top_left_x":244,"top_left_y":829,"width":1615,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9338463f481647b6a0b4960bcd2808b6","type":"text","conversion_output":true,"text":"women receiving the hormone therapy. Of the studies reported here, WHIMS may be the least","text_display":" women receiving the hormone therapy. Of the studies reported here, WHIMS may be the least","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[569,872],[569,915],[245,915]],"region":{"top_left_x":244,"top_left_y":872,"width":326,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9ea43f53fc44c08bf52f0fd1bac0767","type":"text","conversion_output":true,"text":"similar to SPRINT.","text_display":" similar to SPRINT.","confidence":1,"confidence_rate":1},{"cnt":[[402,999],[1714,999],[1714,1680],[402,1680]],"region":{"top_left_x":401,"top_left_y":999,"width":1314,"height":682},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"370afb99650f4af8b01963f78fa1ab03","type":"table","conversion_output":true,"children_ids":["b642866c78a24bc2ae2d31a81d3b1f73","83e8721cd43c4fc3a34b1dc54b08079d","206551e4833a4a6d806ba8e8d3731890","4d70a297c4b3450cb26a0c59c1559e26","09b5dda8ced3442f80f32b2a335d8cb4","01a0bec2af8e49e6acf9ccbb9512332a","16e55424083e489fb4ce5643de48d7b5","eca90ad3f09b43038f5e432a0a61bbb2","dba1caf8ed6243a3af494e40b2c8adcf","21816da4c6a4439b9429799e4ac8d939","d1293a80b6cf4f5a8eb02946175790ac","2c746d21637f4370a47a5c048b3fdca5","0f614d4b47c84c2187302b3662d2162e","f7b01b48eefa459680b6098e612a1dd9","7cdf874a026b4d0ebbb99dd07accd583","47af1e56f756454c8263c29db6fc2e7e","4fec2a1aa47d471a8ab517491987e473","2c2748def14d4a91afdddc4dae82b7f7","1e32d2212bfd42f8a11c9dd69a73a61b","f85d3017fc56414cbe65a502ce790e72","0b3f32d45ece4b9e8a0f485b09d134f3","21c79e4d789449578e043dfc3a6418b5","c3ddf064a24c49d581a2077359035c9c","bab9b1838e024c4b92ebeafdca83971d","bcf06b4d262b47e79287cedd052eeec9","13e7f83821624d67af8d2c7870976d5f","6c67c8fac134459f91ee3657f2c4344b","6ca497905763434eba7c3ffce3c98c25","b76f2ac69d674cd2b87395337c2b0c5a","022fa802c5154d0e98b095847229ae4a","9fa966b9627d414d850161fbb540f871","11ffa3eb1ff04a06926a38cccd564fbe","03f231448d674f8aa2c54d2d67bebb70","97631b0351974dbaae91e39d77af703f","86222735ab7940e597b87baa5c6fa10d","ba1ee0ddfe0e4a7b9bb54f49c5373181","9e3c02448bc948e69b7a3559b0be8f39","2facefa0ed5c46d297d187ca51de1e0a","c310211402db40a0858626a895c26220","ec132457fa5a4f2590ce4c35e978162e","c388a089d156457db9786d0fc99c7689","d176555dfcf34998a53c31be50fe86a3","78285cfc205947c0a14e501485e63f2d","15bb9ed46e9e48aca9d84862a34ff918","2a19c18bda4849a9a69e79905a37399a"],"selected_labels":["4105157607454fd7a4f3b5478af1bd65"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline \\multicolumn{6}{|c|}{Table 1. Annual rates of dementia from previous studies.} \\\\\n\\hline Age & eGFR & HYVET-COG & GEMS & CHS & WHIMS \\\\\n\\hline <75 & & & & 1.29 & 0.08 \\\\\n\\hline 75+ & & & 3.09 (3.86) \\({ }^{1}\\) & 4.55 & 0.81 \\\\\n\\hline & <45 & & 4.87 (6.39) & & \\\\\n\\hline & 45-59.9 & & 3.02 (3.20) & & \\\\\n\\hline & 60-89.9 & & 2.87 (3.70) & & \\\\\n\\hline & 90+ & & 3.86 (4.51) & & \\\\\n\\hline 80+ & & 3.50 & & & \\\\\n\\hline ALL & & 3.50 & 3.09 (3.86) & 2.62 & 0.13 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline \\multicolumn{6}{|c|}{Table 1. Annual rates of dementia from previous studies.} \\\\\n\\hline Age & eGFR & HYVET-COG & GEMS & CHS & WHIMS \\\\\n\\hline <75 & & & & 1.29 & 0.08 \\\\\n\\hline 75+ & & & 3.09 (3.86) \\({ }^{1}\\) & 4.55 & 0.81 \\\\\n\\hline & <45 & & 4.87 (6.39) & & \\\\\n\\hline & 45-59.9 & & 3.02 (3.20) & & \\\\\n\\hline & 60-89.9 & & 2.87 (3.70) & & \\\\\n\\hline & 90+ & & 3.86 (4.51) & & \\\\\n\\hline 80+ & & 3.50 & & & \\\\\n\\hline ALL & & 3.50 & 3.09 (3.86) & 2.62 & 0.13 \\\\\n\\hline\n\\end{tabular}\n\\captionsetup{labelformat=empty}\n\\caption{\\({ }^{1}\\) With prior 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SPRINT will include 2,800 participants receiving the extended cognitive","text_display":"\n\nCognitive Function. SPRINT will include 2,800 participants receiving the extended cognitive","confidence":0.9990236759185791,"confidence_rate":0.999990133371946},{"cnt":[[245,2202],[1880,2202],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2202,"width":1636,"height":48},"line":71,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51739d16207d45c9b7e449d86923998c","type":"text","conversion_output":true,"text":"battery at baseline, and years 2 and 4 post randomization. We obtained the standard deviations","text_display":" battery at baseline, and years 2 and 4 post randomization. We obtained the standard deviations","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1871,2247],[1871,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1628,"height":46},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab18b7dcdd7b4e4daeae9feb32608fa5","type":"text","conversion_output":true,"text":"for several of the tests included in the SPRINT battery to determine detectable differences. The","text_display":" for several of the tests included in the SPRINT battery to determine detectable differences. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[1867,2290],[1867,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2290,"width":1623,"height":46},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e24f6e5919045ac815b9f1082a384c6","type":"text","conversion_output":true,"text":"standard deviation for the Digit Symbol Substitution Test is from actual ACCORD MIND data 40","text_display":" standard deviation for the Digit Symbol Substitution Test is from actual ACCORD MIND data 40","confidence":1,"confidence_rate":1},{"cnt":[[245,2333],[1871,2333],[1871,2380],[245,2380]],"region":{"top_left_x":244,"top_left_y":2333,"width":1628,"height":48},"line":74,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fad00be2033f48cdbcfdc87ff5ebb057","type":"text","conversion_output":true,"text":"months post randomization adjusted for baseline and stratifying factors. Actual means were not","text_display":" months post randomization adjusted for baseline and stratifying factors. Actual means were not","confidence":1,"confidence_rate":1},{"cnt":[[245,2378],[1846,2378],[1846,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2378,"width":1602,"height":48},"line":75,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50c6ef5833cd4afbaf30f75e9d1b7bd4","type":"text","conversion_output":true,"text":"available so we used the ACCORD MIND assumptions in their sample size calculations based","text_display":" available so we used the ACCORD MIND assumptions in their sample size calculations based","confidence":1,"confidence_rate":1},{"cnt":[[245,2423],[1824,2423],[1824,2469],[245,2469]],"region":{"top_left_x":244,"top_left_y":2423,"width":1581,"height":46},"line":76,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cd02cf0becf47aeb076635a6d3f9e68","type":"text","conversion_output":true,"text":"on CHS data. GEMS provided us with standard deviations and means for Trails A \\& B, Digit","text_display":" on CHS data. 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Table 2 shows that we can detect mean differences for","text_display":"\n\nSpan and the Boston Naming Test. Table 2 shows that we can detect mean differences for","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1747,296],[1747,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1503,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1682e2a4c894da29d738072bb276952","type":"text","conversion_output":true,"text":"each test of \\(5.1 \\%\\) or less between the two SPRINT treatment groups at year 4 , with \\(90 \\%\\)","text_display":" each test of \\(5.1 \\%\\) or less between the two SPRINT treatment groups at year 4 , with \\(90 \\%\\)","confidence":0.43228840609663166,"confidence_rate":0.9913019828474569},{"cnt":[[245,339],[1738,339],[1738,385],[245,385]],"region":{"top_left_x":244,"top_left_y":339,"width":1495,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5f3d14f557c49d7b73bcb536087c276","type":"text","conversion_output":true,"text":"statistical power, assuming \\(3 \\%\\) /year loss to follow-up. The statistical power will even be","text_display":" statistical power, assuming \\(3 \\%\\) /year loss to follow-up. The statistical power will even be","confidence":0.6368958950042725,"confidence_rate":0.9954070182422822},{"cnt":[[245,382],[1422,382],[1422,432],[245,432]],"region":{"top_left_x":244,"top_left_y":382,"width":1179,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83b8e9e8b4134317ac679651ff76416d","type":"text","conversion_output":true,"text":"increased when combining the scores for these tests in each domain.","text_display":" increased when combining the scores for these tests in each domain.","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1386,468],[1386,518],[245,518]],"region":{"top_left_x":244,"top_left_y":468,"width":1142,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6dc80810b81499ba70a6986c9e76b1a","type":"figure_label","conversion_output":false,"text":"Table 2. 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Means, standard deviations and power for cognitive tests.}\n\\begin{tabular}{|l|l|l|l|}\n\\hline Cognitive Test & Mean (STD) & \\multicolumn{2}{|c|}{Power} \\\\\n\\hline & & 80\\% & 90\\% \\\\\n\\hline Effect Size & & 0.114 & 0.132 \\\\\n\\hline Digit Symbol Substitution Test & \\(39.5^{1}(7.9)^{2}\\) & 0.90 (2.4\\%) & 1.05 (2.7\\%) \\\\\n\\hline Trails A \\({ }^{3}\\) & 47.5 (18.1) & 2.07 (4.4\\%) & 2.40 (5.1\\%) \\\\\n\\hline Trails B \\({ }^{3}\\) & 124.4 (40.6) & 4.65 (3.7\\%) & 5.38 (4.3\\%) \\\\\n\\hline Digit Span \\({ }^{3}\\) & 13.9 (2.6) & 0.30 (2.2\\%) & 0.34 (2.4\\%) \\\\\n\\hline Boston Naming Test \\({ }^{3}\\) & 26.2 (2.6) & 0.30 (1.1\\%) & 0.34 (1.3\\%) 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