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Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.99462890625,"confidence_rate":0.9999300599792602}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-03","page":3,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"25c0b542f55a449f83cf7cf4e121cd57","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1732,129],[1815,129],[1815,165],[1732,165]],"region":{"top_left_x":1731,"top_left_y":128,"width":85,"height":38},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cfe519ad8a734686a6eead5a7f67db37","type":"page_info","conversion_output":false,"text":"Page 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[511,215],[1766,215],[1766,256],[511,256]],"region":{"top_left_x":511,"top_left_y":214,"width":1256,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1097191fe1934e2fa0fc38709ec630e0","type":"text","conversion_output":true,"text":"technology-enhanced, collaborative care model for treating obese and depressed adults in","text_display":"\ntechnology-enhanced, collaborative care model for treating obese and depressed adults in","confidence":1,"confidence_rate":1},{"cnt":[[56,251],[116,251],[116,2374],[56,2374]],"region":{"top_left_x":55,"top_left_y":251,"width":62,"height":2124},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a095bc8be444bd0a1cdfdeed8c3c610","type":"rotated_container","conversion_output":false,"children_ids":["7d10c54261db40608ca45c1581be4ffe"],"text":"","text_display":""},{"cnt":[[57,251],[112,251],[112,2371],[57,2371]],"region":{"top_left_x":56,"top_left_y":251,"width":56,"height":2120},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d10c54261db40608ca45c1581be4ffe","type":"table","conversion_output":true,"parent_id":"2a095bc8be444bd0a1cdfdeed8c3c610","text":"Author Manuscript Author Manuscript Author Manuscript Author Manuscript","text_display":"\n\nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript","confidence":0.9990236759185791,"confidence_rate":0.9999871474379078},{"cnt":[[516,262],[1497,262],[1497,307],[516,307]],"region":{"top_left_x":515,"top_left_y":262,"width":983,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cf27c459d1e41a1a8fec6e30034c026","type":"text","conversion_output":true,"text":"primary care. This paper describes the study design and methodology.","text_display":"\nprimary care. This paper describes the study design and methodology.","confidence":1,"confidence_rate":1},{"cnt":[[305,352],[535,352],[535,402],[305,402]],"region":{"top_left_x":305,"top_left_y":352,"width":230,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66fd2239a9414a0a9f6eff0bb9a93231","type":"section_header","conversion_output":false,"children_ids":["1b92fdba46fc4b64b02ee33dff8a97d1"],"text":"","text_display":""},{"cnt":[[305,357],[531,357],[531,397],[305,397]],"region":{"top_left_x":305,"top_left_y":356,"width":226,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b92fdba46fc4b64b02ee33dff8a97d1","type":"text","conversion_output":true,"parent_id":"66fd2239a9414a0a9f6eff0bb9a93231","text":"2. Methods","text_display":"\n\n\\section*{2. 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First, PAMF","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[516,561],[1656,561],[1656,604],[516,604]],"region":{"top_left_x":515,"top_left_y":560,"width":1142,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f837cb6070cf46d687bab94fc39863e4","type":"text","conversion_output":true,"text":"patient electronic health records (EHRs) will be pre-screened to identify potential","text_display":" patient electronic health records (EHRs) will be pre-screened to identify potential","confidence":1,"confidence_rate":1},{"cnt":[[516,610],[1794,610],[1794,655],[516,655]],"region":{"top_left_x":515,"top_left_y":610,"width":1279,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c55e19f004554fbcbc9b537258376303","type":"text","conversion_output":true,"text":"participants meeting basic eligibility criteria (e.g., age, BMI, time with PAMF, and absence","text_display":" participants meeting basic eligibility criteria (e.g., age, BMI, time with PAMF, and absence","confidence":1,"confidence_rate":1},{"cnt":[[516,657],[1721,657],[1721,700],[516,700]],"region":{"top_left_x":515,"top_left_y":657,"width":1206,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b7189c21d6748a8b885ff628e2208eb","type":"text","conversion_output":true,"text":"of exclusionary medical or psychiatric comorbidities). Second, primary care providers","text_display":" of exclusionary medical or psychiatric comorbidities). Second, primary care providers","confidence":1,"confidence_rate":1},{"cnt":[[516,707],[1639,707],[1639,750],[516,750]],"region":{"top_left_x":515,"top_left_y":706,"width":1125,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b41c5c8faddc409e8bc14156566480d9","type":"text","conversion_output":true,"text":"(PCPs) will review lists of potentially eligible patients, exclude those they deem","text_display":" (PCPs) will review lists of potentially eligible patients, exclude those they deem","confidence":0.99560546875,"confidence_rate":0.9999493781136879},{"cnt":[[516,756],[1781,756],[1781,799],[516,799]],"region":{"top_left_x":515,"top_left_y":756,"width":1267,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec0b66acb4f64bf88e10b97f7b3051aa","type":"text","conversion_output":true,"text":"inappropriate for the study because of medical reasons, and authorize study contact for the","text_display":" inappropriate for the study because of medical reasons, and authorize study contact for the","confidence":1,"confidence_rate":1},{"cnt":[[516,804],[1772,804],[1772,846],[516,846]],"region":{"top_left_x":515,"top_left_y":803,"width":1258,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80c6f56cc3e144bda59fa5ca7a9f6a89","type":"text","conversion_output":true,"text":"rest. Third, patients will be mailed or emailed study invitations that contain a web link for","text_display":" rest. Third, patients will be mailed or emailed study invitations that contain a web link for","confidence":1,"confidence_rate":1},{"cnt":[[516,853],[1798,853],[1798,896],[516,896]],"region":{"top_left_x":515,"top_left_y":852,"width":1284,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bcc70b72fa146179f951a74264387d0","type":"text","conversion_output":true,"text":"the study screening form that patients can complete on their own or with research staff over","text_display":" the study screening form that patients can complete on their own or with research staff over","confidence":1,"confidence_rate":1},{"cnt":[[516,902],[1768,902],[1768,943],[516,943]],"region":{"top_left_x":515,"top_left_y":902,"width":1254,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d07cd2bf6eb4b10930471811ea4ca72","type":"text","conversion_output":true,"text":"the phone. Research staff will begin calling patients 2 weeks after the invitations are sent.","text_display":" the phone. Research staff will begin calling patients 2 weeks after the invitations are sent.","confidence":1,"confidence_rate":1},{"cnt":[[516,950],[1781,950],[1781,993],[516,993]],"region":{"top_left_x":515,"top_left_y":949,"width":1267,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f096686d9b9c4dca8ebe104ad92db81a","type":"text","conversion_output":true,"text":"Fourth, patients who screen eligible must complete the baseline assessment consisting of a","text_display":" Fourth, patients who screen eligible must complete the baseline assessment consisting of a","confidence":1,"confidence_rate":1},{"cnt":[[516,999],[1779,999],[1779,1042],[516,1042]],"region":{"top_left_x":515,"top_left_y":999,"width":1264,"height":43},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e41401287694e1f8d3d92b489955907","type":"text","conversion_output":true,"text":"self-administered online questionnaire and an in-person examination visit. Finally, a study","text_display":" self-administered online questionnaire and an in-person examination visit. Finally, a study","confidence":1,"confidence_rate":1},{"cnt":[[516,1044],[1727,1044],[1727,1089],[516,1089]],"region":{"top_left_x":515,"top_left_y":1044,"width":1213,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b4b6eb1bc7b4e37b86a63f962bb822b","type":"text","conversion_output":true,"text":"physician will review patients' EHRs to confirm final eligibility before randomization.","text_display":" physician will review patients' EHRs to confirm final eligibility before randomization.","confidence":1,"confidence_rate":1},{"cnt":[[516,1096],[1790,1096],[1790,1139],[516,1139]],"region":{"top_left_x":515,"top_left_y":1095,"width":1275,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bb21ebd8d754bef83cc1cf0ec5ba38f","type":"text","conversion_output":true,"text":"Based on the demographics of obese and depressed patients seen in primary care at PAMF,","text_display":" Based on the demographics of obese and depressed patients seen in primary care at PAMF,","confidence":1,"confidence_rate":1},{"cnt":[[516,1143],[1742,1143],[1742,1188],[516,1188]],"region":{"top_left_x":515,"top_left_y":1142,"width":1228,"height":47},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd08c8440ae34af2998d640bed1762bc","type":"text","conversion_output":true,"text":"the gender and minority racial/ethnic composition of the target enrollment population is","text_display":" the gender and minority racial/ethnic composition of the target enrollment population is","confidence":1,"confidence_rate":1},{"cnt":[[516,1192],[1725,1192],[1725,1235],[516,1235]],"region":{"top_left_x":515,"top_left_y":1192,"width":1211,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57421d5387664b518d50d5092239bb1b","type":"text","conversion_output":true,"text":"estimated to be \\(64 \\%\\) female, \\(10 \\%\\) non-Hispanic black, 18\\% Hispanic/Latino, and 44\\%","text_display":" estimated to be \\(64 \\%\\) female, \\(10 \\%\\) non-Hispanic black, 18\\% Hispanic/Latino, and 44\\%","confidence":0.5861490101829151,"confidence_rate":0.9941470720158276},{"cnt":[[516,1242],[612,1242],[612,1278],[516,1278]],"region":{"top_left_x":515,"top_left_y":1241,"width":98,"height":38},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e53f981f021f459fb41e431c7a693b94","type":"text","conversion_output":true,"text":"Asian.","text_display":" Asian.","confidence":1,"confidence_rate":1},{"cnt":[[303,1328],[855,1328],[855,1377],[303,1377]],"region":{"top_left_x":302,"top_left_y":1327,"width":554,"height":51},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae05fb7dbbfd41038510e17662c616f7","type":"section_header","conversion_output":false,"children_ids":["39c23d84b9e946ce8c24c48cd58766a5"],"text":"","text_display":""},{"cnt":[[305,1332],[853,1332],[853,1375],[305,1375]],"region":{"top_left_x":305,"top_left_y":1332,"width":548,"height":43},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39c23d84b9e946ce8c24c48cd58766a5","type":"text","conversion_output":true,"parent_id":"ae05fb7dbbfd41038510e17662c616f7","text":"2.4. Randomization and Blinding","text_display":"\n\n\\subsection*{2.4. 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The web-based randomization program","text_display":" control group or the I-CARE intervention group. The web-based randomization program","confidence":1,"confidence_rate":1},{"cnt":[[516,1583],[1809,1583],[1809,1631],[516,1631]],"region":{"top_left_x":515,"top_left_y":1583,"width":1294,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a586b155e74144e79288ae39dc8893f3","type":"text","conversion_output":true,"text":"uses Pocock's minimization, a covariate-adaptive method, \\({ }^{26,27}\\) to achieve better than chance","text_display":" uses Pocock's minimization, a covariate-adaptive method, \\({ }^{26,27}\\) to achieve better than chance","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[516,1637],[1811,1637],[1811,1680],[516,1680]],"region":{"top_left_x":515,"top_left_y":1637,"width":1297,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66b833b27a194abe923c29e84dce870b","type":"text","conversion_output":true,"text":"marginal balance between study arms across multiple baseline characteristics: clinic, gender,","text_display":" marginal balance between study arms across multiple baseline characteristics: clinic, gender,","confidence":1,"confidence_rate":1},{"cnt":[[516,1684],[1721,1684],[1721,1729],[516,1729]],"region":{"top_left_x":515,"top_left_y":1684,"width":1206,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c573956f32540ee86fbd7799526562a","type":"text","conversion_output":true,"text":"age, race/ethnicity, education, BMI, SCL-20 score, therapeutic class of antidepressant","text_display":" age, race/ethnicity, education, BMI, SCL-20 score, therapeutic class of antidepressant","confidence":1,"confidence_rate":1},{"cnt":[[516,1732],[1749,1732],[1749,1777],[516,1777]],"region":{"top_left_x":515,"top_left_y":1731,"width":1234,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d30b6439ed344fd7ae6b357bf029f22f","type":"text","conversion_output":true,"text":"medication taken, and number of hospitalization. The system's computational algorithm","text_display":" medication taken, and number of hospitalization. The system's computational algorithm","confidence":1,"confidence_rate":1},{"cnt":[[516,1783],[1764,1783],[1764,1824],[516,1824]],"region":{"top_left_x":515,"top_left_y":1783,"width":1249,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85e8d48b192745049aa42602ce01ff07","type":"text","conversion_output":true,"text":"automatically adjusts the randomization probability based on the characteristics of all the","text_display":" automatically adjusts the randomization probability based on the characteristics of all the","confidence":1,"confidence_rate":1},{"cnt":[[516,1830],[1794,1830],[1794,1876],[516,1876]],"region":{"top_left_x":515,"top_left_y":1830,"width":1279,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ffa0f0df0a24deba0ac9061dda6bcac","type":"text","conversion_output":true,"text":"previously randomized participants, thus minimizing the total covariate imbalance between","text_display":" previously randomized participants, thus minimizing the total covariate imbalance between","confidence":1,"confidence_rate":1},{"cnt":[[516,1876],[1721,1876],[1721,1923],[516,1923]],"region":{"top_left_x":515,"top_left_y":1875,"width":1206,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30d6ad20d74a4cafabe818ed4ca09203","type":"text","conversion_output":true,"text":"arms after each new patient is randomized. Efron's biased-coin method \\({ }^{28}\\) is applied to","text_display":" arms after each new patient is randomized. Efron's biased-coin method \\({ }^{28}\\) is applied to","confidence":1,"confidence_rate":1},{"cnt":[[516,1929],[1742,1929],[1742,1970],[516,1970]],"region":{"top_left_x":515,"top_left_y":1929,"width":1228,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef08ae67ef944e63998de69edfd24945","type":"text","conversion_output":true,"text":"protect allocation concealment with the use of non-extreme randomization probabilities","text_display":" protect allocation concealment with the use of non-extreme randomization probabilities","confidence":1,"confidence_rate":1},{"cnt":[[516,1977],[1762,1977],[1762,2022],[516,2022]],"region":{"top_left_x":515,"top_left_y":1976,"width":1247,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"881d70045fd347d681e046ee79f5e318","type":"text","conversion_output":true,"text":"\\((2 / 3: 1 / 3)\\). Specifically, for each patient about to be randomized, the system automatically","text_display":" \\((2 / 3: 1 / 3)\\). Specifically, for each patient about to be randomized, the system automatically","confidence":0.67578125,"confidence_rate":0.9958833823861309},{"cnt":[[516,2024],[1807,2024],[1807,2067],[516,2067]],"region":{"top_left_x":515,"top_left_y":2023,"width":1292,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"283e8ce0a6a749628babf423750baf76","type":"text","conversion_output":true,"text":"calculates an imbalance score for each of the above-mentioned baseline covariates, and then","text_display":" calculates an imbalance score for each of the above-mentioned baseline covariates, and then","confidence":0.9990234375,"confidence_rate":0.999989822555459},{"cnt":[[516,2075],[1760,2075],[1760,2116],[516,2116]],"region":{"top_left_x":515,"top_left_y":2075,"width":1245,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"823a922176854a08a57fc9fdda93e5f9","type":"text","conversion_output":true,"text":"a total imbalance score, S , by summing across the covariates. If \\(S =0\\), the randomization","text_display":" a total imbalance score, S , by summing across the covariates. If \\(S =0\\), the randomization","confidence":1,"confidence_rate":1},{"cnt":[[516,2123],[1775,2123],[1775,2168],[516,2168]],"region":{"top_left_x":515,"top_left_y":2122,"width":1260,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f2ea680e58b46c28c7afdd3e05d2339","type":"text","conversion_output":true,"text":"probability for receiving the intervention for that patient will be set to \\(\\frac{1}{2}\\), and if \\(S <0\\) ( \\(S >\\)","text_display":" probability for receiving the intervention for that patient will be set to \\(\\frac{1}{2}\\), and if \\(S <0\\) ( \\(S >\\)","confidence":0.9956109506310895,"confidence_rate":0.999962080809275},{"cnt":[[516,2170],[1308,2170],[1308,2215],[516,2215]],"region":{"top_left_x":515,"top_left_y":2169,"width":794,"height":47},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffdbc7acd72e4f0dad887c37cd75d213","type":"text","conversion_output":true,"text":"0 ), the randomization probability will be set to \\(2 / 3(1 / 3)\\).","text_display":" 0 ), the randomization probability will be set to \\(2 / 3(1 / 3)\\).","confidence":0.93603515625,"confidence_rate":0.9990138858869091},{"cnt":[[516,2256],[1798,2256],[1798,2299],[516,2299]],"region":{"top_left_x":515,"top_left_y":2255,"width":1284,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"448ffc0ac7d84bd2b74acdabc98496a1","type":"text","conversion_output":true,"text":"By design, treatment assignments are identifiable to participants and the lifestyle coach, but","text_display":"\n\nBy design, treatment assignments are identifiable to participants and the lifestyle coach, but","confidence":1,"confidence_rate":1},{"cnt":[[516,2303],[1772,2303],[1772,2346],[516,2346]],"region":{"top_left_x":515,"top_left_y":2303,"width":1258,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6f87a92cdbe44d5bbdb4791556c75b4","type":"text","conversion_output":true,"text":"the investigators, data and safety monitoring board members, outcome assessors, and data","text_display":" the investigators, data and safety monitoring board members, outcome assessors, and data","confidence":1,"confidence_rate":1},{"cnt":[[556,2479],[1381,2479],[1381,2516],[556,2516]],"region":{"top_left_x":556,"top_left_y":2479,"width":826,"height":37},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d7eeb477c25c40cda04cff110f44d438","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.99462890625,"confidence_rate":0.9999300599792602}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-05","page":5,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f352f7fda904107b79b9d6450e50dcb","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1732,129],[1815,129],[1815,165],[1732,165]],"region":{"top_left_x":1731,"top_left_y":128,"width":85,"height":38},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c28f0cbcfe48403980553b1442bc4096","type":"page_info","conversion_output":false,"text":"Page 5","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[516,215],[1807,215],[1807,256],[516,256]],"region":{"top_left_x":515,"top_left_y":214,"width":1292,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1445f4f001a64645965a199d0129a8f7","type":"text","conversion_output":true,"text":"analyst will be blinded throughout the trial. 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Continuation of Usual Care}","confidence":1,"confidence_rate":1},{"cnt":[[518,417],[1777,417],[1777,458],[518,458]],"region":{"top_left_x":517,"top_left_y":416,"width":1260,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8e9743ed369455d9df4dde39a99fe67","type":"text","conversion_output":true,"text":"We will recruit from patients who have used PAMF for routine care for at least 1 year and","text_display":"\n\nWe will recruit from patients who have used PAMF for routine care for at least 1 year and","confidence":1,"confidence_rate":1},{"cnt":[[518,464],[1807,464],[1807,505],[518,505]],"region":{"top_left_x":517,"top_left_y":464,"width":1290,"height":41},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68e1c06eeb8a42a39e1abd0e9e6663f6","type":"text","conversion_output":true,"text":"thus have a higher likelihood of an established relationship with their PCP. During informed","text_display":" thus have a higher likelihood of an established relationship with their PCP. During informed","confidence":1,"confidence_rate":1},{"cnt":[[518,513],[1790,513],[1790,554],[518,554]],"region":{"top_left_x":517,"top_left_y":513,"width":1273,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ac8b6b153ae4f81abec219dc85f3f64","type":"text","conversion_output":true,"text":"consent, patients will be clearly instructed that they should continue to receive any medical","text_display":" consent, patients will be clearly instructed that they should continue to receive any medical","confidence":1,"confidence_rate":1},{"cnt":[[518,563],[1605,563],[1605,604],[518,604]],"region":{"top_left_x":517,"top_left_y":562,"width":1088,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"198c8e8a257a423daf58fbe67561db87","type":"text","conversion_output":true,"text":"care (e.g., depression and weight control care) as usual. For patient safety and","text_display":" care (e.g., depression and weight control care) as usual. For patient safety and","confidence":1,"confidence_rate":1},{"cnt":[[518,610],[1704,610],[1704,655],[518,655]],"region":{"top_left_x":517,"top_left_y":610,"width":1187,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11ce3fa7fd174efba27e6d05214cc8ae","type":"text","conversion_output":true,"text":"generalizability, no standard care will be withheld at any time from participants once","text_display":" generalizability, no standard care will be withheld at any time from participants once","confidence":1,"confidence_rate":1},{"cnt":[[518,657],[1807,657],[1807,698],[518,698]],"region":{"top_left_x":517,"top_left_y":657,"width":1290,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d02d7373aa5a40b0863b10df37ccbfa5","type":"text","conversion_output":true,"text":"enrolled, regardless of treatment assignment. They will be advised to consult with their PCP","text_display":" enrolled, regardless of treatment assignment. They will be advised to consult with their PCP","confidence":1,"confidence_rate":1},{"cnt":[[516,707],[1815,707],[1815,750],[516,750]],"region":{"top_left_x":515,"top_left_y":706,"width":1301,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4daa4804b7a4a039049c62c211d03c1","type":"text","conversion_output":true,"text":"about their conditions. PCPs will be free to prescribe medications or refer patients for mental","text_display":" about their conditions. PCPs will be free to prescribe medications or refer patients for mental","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[516,756],[1779,756],[1779,797],[516,797]],"region":{"top_left_x":515,"top_left_y":756,"width":1264,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0e2bb51977d46f1bd6fe59cb167d9ce","type":"text","conversion_output":true,"text":"health and/or obesity consultation, and patients will be free to seek care in the community.","text_display":" health and/or obesity consultation, and patients will be free to seek care in the community.","confidence":1,"confidence_rate":1},{"cnt":[[516,804],[1815,804],[1815,846],[516,846]],"region":{"top_left_x":515,"top_left_y":803,"width":1301,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a8433c8228e46d69bb3137ee09f6269","type":"text","conversion_output":true,"text":"All participants will receive information on PAMF health and wellness classes and programs","text_display":" All participants will receive information on PAMF health and wellness classes and programs","confidence":1,"confidence_rate":1},{"cnt":[[516,853],[1618,853],[1618,896],[516,896]],"region":{"top_left_x":515,"top_left_y":852,"width":1103,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cc96960cb35474e83824bb95e111bcb","type":"text","conversion_output":true,"text":"relating to mood and weight, as well as a Fitbit ZIP™ wireless activity tracker.","text_display":" relating to mood and weight, as well as a Fitbit ZIP™ wireless activity tracker.","confidence":0.89697265625,"confidence_rate":0.9987510116596374},{"cnt":[[516,937],[1699,937],[1699,978],[516,978]],"region":{"top_left_x":515,"top_left_y":936,"width":1185,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92d2dbfa2bd2445ca0b6551d0021a829","type":"text","conversion_output":true,"text":"To retain the integrity of usual care, PCPs will not be told which of their patients are","text_display":"\n\nTo retain the integrity of usual care, PCPs will not be told which of their patients are","confidence":1,"confidence_rate":1},{"cnt":[[518,984],[1811,984],[1811,1029],[518,1029]],"region":{"top_left_x":517,"top_left_y":983,"width":1295,"height":47},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b7515f4512e41a1b26c88dd04ed3e63","type":"text","conversion_output":true,"text":"enrolled in the study and in which treatment group if enrolled. They will only identify which","text_display":" enrolled in the study and in which treatment group if enrolled. They will only identify which","confidence":1,"confidence_rate":1},{"cnt":[[518,1033],[1794,1033],[1794,1076],[518,1076]],"region":{"top_left_x":517,"top_left_y":1033,"width":1277,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99273252d54445d19e8a1b1e828bfc2a","type":"text","conversion_output":true,"text":"of their patients are in the I-CARE intervention if and when they are contacted by the study","text_display":" of their patients are in the I-CARE intervention if and when they are contacted by the study","confidence":1,"confidence_rate":1},{"cnt":[[518,1083],[1807,1083],[1807,1124],[518,1124]],"region":{"top_left_x":517,"top_left_y":1082,"width":1290,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44b603bffeb54711984e86e47956d81c","type":"text","conversion_output":true,"text":"care team to make antidepressant medication changes. We anticipate the number of I-CARE","text_display":" care team to make antidepressant medication changes. We anticipate the number of I-CARE","confidence":1,"confidence_rate":1},{"cnt":[[516,1130],[1777,1130],[1777,1175],[516,1175]],"region":{"top_left_x":515,"top_left_y":1130,"width":1262,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64f3110eebfd4957999212284675e41f","type":"text","conversion_output":true,"text":"participants per PCP to be small considering we will be recruiting at multiple large PAMF","text_display":" participants per PCP to be small considering we will be recruiting at multiple large PAMF","confidence":1,"confidence_rate":1},{"cnt":[[516,1182],[810,1182],[810,1222],[516,1222]],"region":{"top_left_x":515,"top_left_y":1181,"width":295,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0741bc50e2ca4c0596fd16c0b97f9836","type":"text","conversion_output":true,"text":"primary care clinics.","text_display":" primary care clinics.","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[518,1263],[1669,1263],[1669,1308],[518,1308]],"region":{"top_left_x":517,"top_left_y":1263,"width":1153,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0603dddcc1e043b398d335f4bd8afbdd","type":"text","conversion_output":true,"text":"Based on our prior primary care-based trials, we anticipate low rates of changes in","text_display":"\n\nBased on our prior primary care-based trials, we anticipate low rates of changes in","confidence":1,"confidence_rate":1},{"cnt":[[516,1311],[1815,1311],[1815,1354],[516,1354]],"region":{"top_left_x":515,"top_left_y":1310,"width":1301,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3cc7d5ff04a242ab9e9bd208b61699a9","type":"text","conversion_output":true,"text":"concomitant therapy for depression or obesity in usual care within the 12-month intervention","text_display":" concomitant therapy for depression or obesity in usual care within the 12-month intervention","confidence":0.96142578125,"confidence_rate":0.9995945367840826},{"cnt":[[516,1354],[1815,1354],[1815,1403],[516,1403]],"region":{"top_left_x":515,"top_left_y":1353,"width":1301,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9915d6c8e0b4b2aac5aae046904da42","type":"text","conversion_output":true,"text":"period. In the TEAMcare study, \\({ }^{29}\\) the number of antidepressant medication initiations and/or","text_display":" period. In the TEAMcare study, \\({ }^{29}\\) the number of antidepressant medication initiations and/or","confidence":1,"confidence_rate":1},{"cnt":[[516,1405],[1768,1405],[1768,1450],[516,1450]],"region":{"top_left_x":515,"top_left_y":1405,"width":1254,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fbc9ce3a4324546887cdbfe5efd5a04","type":"text","conversion_output":true,"text":"adjustments in the TEAMcare intervention (3.37; 95\\% CI, 2.92-3.89) was 6.2 times ( \\(P <\\).","text_display":" adjustments in the TEAMcare intervention (3.37; 95\\% CI, 2.92-3.89) was 6.2 times ( \\(P <\\).","confidence":0.9743118723854423,"confidence_rate":0.999742371517949},{"cnt":[[516,1452],[1811,1452],[1811,1497],[516,1497]],"region":{"top_left_x":515,"top_left_y":1452,"width":1297,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d646921cd7f848f28ee44f8bad69d113","type":"text","conversion_output":true,"text":"001) that of usual care ( 0.53 ; 0.34-0.82) over 12 months. In the 15-month E-LITE trial, \\({ }^{24}\\) no","text_display":" 001) that of usual care ( 0.53 ; 0.34-0.82) over 12 months. In the 15-month E-LITE trial, \\({ }^{24}\\) no","confidence":0.4324876407483935,"confidence_rate":0.9928001686161306},{"cnt":[[516,1504],[1807,1504],[1807,1549],[516,1549]],"region":{"top_left_x":515,"top_left_y":1503,"width":1292,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c163f850ac54643a6be42416f545798","type":"text","conversion_output":true,"text":"one had drug or surgical treatment for obesity; 15 of the \\(81(19 \\%)\\) usual care controls used a","text_display":" one had drug or surgical treatment for obesity; 15 of the \\(81(19 \\%)\\) usual care controls used a","confidence":0.77734375,"confidence_rate":0.997557622229591},{"cnt":[[516,1555],[1772,1555],[1772,1596],[516,1596]],"region":{"top_left_x":515,"top_left_y":1555,"width":1258,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3af158ce3a5e440390cdee81c2fd31a5","type":"text","conversion_output":true,"text":"nonstudy weight-loss program ( 13 in a commercial program and 2 in a routine class at the","text_display":" nonstudy weight-loss program ( 13 in a commercial program and 2 in a routine class at the","confidence":0.9985356330871582,"confidence_rate":0.9999853457059158},{"cnt":[[516,1603],[1661,1603],[1661,1646],[516,1646]],"region":{"top_left_x":515,"top_left_y":1602,"width":1146,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"907e0109ef5e47c9a04b65fea3576fc2","type":"text","conversion_output":true,"text":"clinic), compared to 5 of the \\(79(6 \\%)\\) coach-led and 3 of the \\(81(4 \\%)\\) self-directed","text_display":" clinic), compared to 5 of the \\(79(6 \\%)\\) coach-led and 3 of the \\(81(4 \\%)\\) self-directed","confidence":0.8269844055175781,"confidence_rate":0.9980434686640802},{"cnt":[[516,1650],[1326,1650],[1326,1695],[516,1695]],"region":{"top_left_x":515,"top_left_y":1650,"width":811,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"287b95e075624ad18820786ae40dc27d","type":"text","conversion_output":true,"text":"participants (all used a commercial program) ( \\(P=0.003\\) ).","text_display":" participants (all used a commercial program) ( \\(P=0.003\\) ).","confidence":0.92724609375,"confidence_rate":0.9988385784289003},{"cnt":[[516,1736],[1781,1736],[1781,1777],[516,1777]],"region":{"top_left_x":515,"top_left_y":1735,"width":1267,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e0e71e0e6d049efb1654fe96ee61552","type":"text","conversion_output":true,"text":"As we have done in those trials, from the EHR we will determine PCP orders and referrals","text_display":"\n\nAs we have done in those trials, from the EHR we will determine PCP orders and referrals","confidence":1,"confidence_rate":1},{"cnt":[[516,1783],[1747,1783],[1747,1826],[516,1826]],"region":{"top_left_x":515,"top_left_y":1783,"width":1232,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2303efdc4f743c28b9c2e1fb5a3dce7","type":"text","conversion_output":true,"text":"throughout the trial period for intervention and control participants. We will also survey","text_display":" throughout the trial period for intervention and control participants. We will also survey","confidence":1,"confidence_rate":1},{"cnt":[[516,1833],[1772,1833],[1772,1876],[516,1876]],"region":{"top_left_x":515,"top_left_y":1832,"width":1258,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdaf2eff14ba43da933121292bae735b","type":"text","conversion_output":true,"text":"participants about any programs or products that they may have used on their own to treat","text_display":" participants about any programs or products that they may have used on their own to treat","confidence":1,"confidence_rate":1},{"cnt":[[516,1882],[1815,1882],[1815,1923],[516,1923]],"region":{"top_left_x":515,"top_left_y":1882,"width":1301,"height":41},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2027b94be10545fe81b4e5deaf713e49","type":"text","conversion_output":true,"text":"depression or obesity during the trial. We will conduct secondary analyses using data on out-","text_display":" depression or obesity during the trial. We will conduct secondary analyses using data on out-","confidence":1,"confidence_rate":1},{"cnt":[[516,1929],[1807,1929],[1807,1972],[516,1972]],"region":{"top_left_x":515,"top_left_y":1929,"width":1292,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"246c33d826e9454382ff968b7d4a4e30","type":"text","conversion_output":true,"text":"of-study treatments to elucidate their potential confounding effects on the primary intention-","text_display":"of-study treatments to elucidate their potential confounding effects on the primary intention-","confidence":1,"confidence_rate":1},{"cnt":[[516,1977],[754,1977],[754,2022],[516,2022]],"region":{"top_left_x":515,"top_left_y":1976,"width":240,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6487e19ca00f4a2a8359aac8ae4466c9","type":"text","conversion_output":true,"text":"to-treat findings.","text_display":"to-treat findings.","confidence":1,"confidence_rate":1},{"cnt":[[305,2067],[587,2067],[587,2108],[305,2108]],"region":{"top_left_x":305,"top_left_y":2066,"width":282,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54b769568e0643e782c1f48bb7a94405","type":"section_header","conversion_output":false,"children_ids":["74d998c32b634bcf97a758a9bb54675c"],"text":"","text_display":""},{"cnt":[[305,2069],[582,2069],[582,2103],[305,2103]],"region":{"top_left_x":305,"top_left_y":2068,"width":278,"height":36},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74d998c32b634bcf97a758a9bb54675c","type":"text","conversion_output":true,"parent_id":"54b769568e0643e782c1f48bb7a94405","text":"2.6. Intervention","text_display":"\n\n\\subsection*{2.6. Intervention}","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[516,2131],[1794,2131],[1794,2172],[516,2172]],"region":{"top_left_x":515,"top_left_y":2131,"width":1279,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25363740d06d47d88ef374e9ed8b180d","type":"text","conversion_output":true,"text":"Participants in the control group will receive no intervention from the study. Participants in","text_display":"\n\nParticipants in the control group will receive no intervention from the study. Participants in","confidence":1,"confidence_rate":1},{"cnt":[[516,2179],[1772,2179],[1772,2221],[516,2221]],"region":{"top_left_x":515,"top_left_y":2178,"width":1258,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f478e8dcb7494cc488a02117d93f3700","type":"text","conversion_output":true,"text":"the I-CARE group will complete a 12 -month integrated intervention for comorbid obesity","text_display":" the I-CARE group will complete a 12 -month integrated intervention for comorbid obesity","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[516,2230],[741,2230],[741,2271],[516,2271]],"region":{"top_left_x":515,"top_left_y":2230,"width":227,"height":41},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e16a89cd0ff341a6ba834cd44aa2c524","type":"text","conversion_output":true,"text":"and depression.","text_display":" and depression.","confidence":1,"confidence_rate":1},{"cnt":[[516,2318],[1807,2318],[1807,2361],[516,2361]],"region":{"top_left_x":515,"top_left_y":2318,"width":1292,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fdd7e4fae0a41c7968d69d06a92cdea","type":"text","conversion_output":true,"text":"2.6.1. 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During the maintenance","text_display":" solving session due to overlap with PST) during visits 6 through 9. 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The","text_display":" participants and provide between-session support via EHR-embedded secure email. The","confidence":1,"confidence_rate":1},{"cnt":[[516,1590],[1803,1590],[1803,1635],[516,1635]],"region":{"top_left_x":515,"top_left_y":1589,"width":1288,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a66f4796f7f4dbbacc81eaf105b8d6a","type":"text","conversion_output":true,"text":"coach will provide lifestyle counseling following the GLB program on weight management,","text_display":" coach will provide lifestyle counseling following the GLB program on weight management,","confidence":1,"confidence_rate":1},{"cnt":[[516,1637],[1807,1637],[1807,1682],[516,1682]],"region":{"top_left_x":515,"top_left_y":1637,"width":1292,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29a32d48535c42c59858f9bc5301cff4","type":"text","conversion_output":true,"text":"healthy eating, and physical activity after GLB is introduced. The coach and participant will","text_display":" healthy eating, and physical activity after GLB is introduced. The coach and participant will","confidence":1,"confidence_rate":1},{"cnt":[[516,1687],[1772,1687],[1772,1732],[516,1732]],"region":{"top_left_x":515,"top_left_y":1686,"width":1258,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b43d1cc2f8348ebbdfe1453896d25d7","type":"text","conversion_output":true,"text":"develop a maintenance plan once targeted depression and weight loss goals (or a personal","text_display":" develop a maintenance plan once targeted depression and weight loss goals (or a personal","confidence":1,"confidence_rate":1},{"cnt":[[516,1732],[1790,1732],[1790,1781],[516,1781]],"region":{"top_left_x":515,"top_left_y":1731,"width":1275,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7ba9e6baf9042839a4033c88a9e90c9","type":"text","conversion_output":true,"text":"maximum achievable level of improvement) are reached for at least 1 month, and a relapse","text_display":" maximum achievable level of improvement) are reached for at least 1 month, and a relapse","confidence":1,"confidence_rate":1},{"cnt":[[516,1783],[1807,1783],[1807,1828],[516,1828]],"region":{"top_left_x":515,"top_left_y":1783,"width":1292,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa10e3d5fbcf4184bf342f799190ad90","type":"text","conversion_output":true,"text":"prevention plan when the participant is nearing the end of the 12-month intervention. 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After each one-on-one visit, the coach will document patient progress on key","text_display":" providers. After each one-on-one visit, the coach will document patient progress on key","confidence":1,"confidence_rate":1},{"cnt":[[516,2312],[1691,2312],[1691,2357],[516,2357]],"region":{"top_left_x":515,"top_left_y":2311,"width":1176,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6f2871a52c2475bb199d33aff6f7f47","type":"text","conversion_output":true,"text":"intervention tracking parameters (e.g., date and content; most current Patient Health","text_display":" intervention tracking parameters (e.g., date and content; most current Patient Health","confidence":0.9990234375,"confidence_rate":0.9999891440628391},{"cnt":[[516,2359],[1721,2359],[1721,2408],[516,2408]],"region":{"top_left_x":515,"top_left_y":2358,"width":1206,"height":51},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68a7426b1c084f41bcd10f835522336a","type":"text","conversion_output":true,"text":"Questionnaire-9 [PHQ-9] score; pedometer steps; self-reported weight and minutes of","text_display":" Questionnaire-9 [PHQ-9] score; pedometer steps; self-reported weight and minutes of","confidence":0.9931750223063884,"confidence_rate":0.9999221805920739},{"cnt":[[554,2479],[1381,2479],[1381,2516],[554,2516]],"region":{"top_left_x":554,"top_left_y":2479,"width":828,"height":37},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3ba3d5af72ba4d2db6d19551733a21e6","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.998046875,"confidence_rate":0.9999746102595223}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-08","page":8,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c039b33fb3fa4023bddd6fbc4d6101f8","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1732,131],[1815,131],[1815,165],[1732,165]],"region":{"top_left_x":1731,"top_left_y":131,"width":85,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d7b3428facfc4958836967ee4545e68e","type":"page_info","conversion_output":false,"text":"Page 8","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[511,202],[1721,202],[1721,260],[511,260]],"region":{"top_left_x":511,"top_left_y":201,"width":1210,"height":59},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbc4f5571a0448e58d284543f3929014","type":"text","conversion_output":true,"text":"physical activity) in the EHR-viewable by all providers on the patient's care team to","text_display":"\nphysical activity) in the EHR-viewable by all providers on the patient's care team to","confidence":0.876584529876709,"confidence_rate":0.998537491187409},{"cnt":[[54,249],[118,249],[118,2374],[54,2374]],"region":{"top_left_x":53,"top_left_y":249,"width":66,"height":2126},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"faefeb0fba88448a9af33a3ff1f804e3","type":"rotated_container","conversion_output":false,"children_ids":["8638016c504642e991ce815b8076ab33"],"text":"","text_display":""},{"cnt":[[59,254],[114,254],[114,2372],[59,2372]],"region":{"top_left_x":58,"top_left_y":254,"width":56,"height":2118},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8638016c504642e991ce815b8076ab33","type":"table","conversion_output":true,"parent_id":"faefeb0fba88448a9af33a3ff1f804e3","text":"Author Manuscript Author Manuscript Author Manuscript Author Manuscript","text_display":"\n\nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript","confidence":0.9970729344058782,"confidence_rate":0.9999614302460895},{"cnt":[[516,262],[1811,262],[1811,307],[516,307]],"region":{"top_left_x":515,"top_left_y":262,"width":1297,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a0a01ead61744f98f6abeb1db16566a","type":"text","conversion_output":true,"text":"facilitate care coordination. Working together as a study care team, the coach will meet for 2","text_display":"\nfacilitate care coordination. Working together as a study care team, the coach will meet for 2","confidence":1,"confidence_rate":1},{"cnt":[[516,309],[1745,309],[1745,354],[516,354]],"region":{"top_left_x":515,"top_left_y":309,"width":1230,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e627e2058a146509c9028e036b8883c","type":"text","conversion_output":true,"text":"hours each week with the study psychiatrist, study physician, and intervention manager.","text_display":" hours each week with the study psychiatrist, study physician, and intervention manager.","confidence":1,"confidence_rate":1},{"cnt":[[516,357],[1772,357],[1772,402],[516,402]],"region":{"top_left_x":515,"top_left_y":356,"width":1258,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84de37b0c18b4ee2988d04c745324745","type":"text","conversion_output":true,"text":"They use an online tracking database to view each participant's progress for ongoing case","text_display":" They use an online tracking database to view each participant's progress for ongoing case","confidence":1,"confidence_rate":1},{"cnt":[[516,408],[1710,408],[1710,453],[516,453]],"region":{"top_left_x":515,"top_left_y":408,"width":1196,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcff197dbaa64b52b0990cd23925c7c1","type":"text","conversion_output":true,"text":"management. The form will include a flag for cases not meeting pre-defined progress","text_display":" management. The form will include a flag for cases not meeting pre-defined progress","confidence":1,"confidence_rate":1},{"cnt":[[516,455],[1811,455],[1811,501],[516,501]],"region":{"top_left_x":515,"top_left_y":455,"width":1297,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68b8b1522e064a9b9f0dc0f11fbea170","type":"text","conversion_output":true,"text":"milestones for depression (e.g., compared to visit 1, PHQ-9 score \\(<25 \\%\\) decrease by week 4;","text_display":" milestones for depression (e.g., compared to visit 1, PHQ-9 score \\(<25 \\%\\) decrease by week 4;","confidence":0.993659496307373,"confidence_rate":0.9999350971056796},{"cnt":[[516,505],[1729,505],[1729,552],[516,552]],"region":{"top_left_x":515,"top_left_y":504,"width":1215,"height":49},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f95174de03164d20a5b2348f434377cc","type":"text","conversion_output":true,"text":"another \\(<25 \\%\\) decrease by week 8; or PHQ-9 score \\(>5\\) or \\(<50 \\%\\) decrease by week 12),","text_display":" another \\(<25 \\%\\) decrease by week 8; or PHQ-9 score \\(>5\\) or \\(<50 \\%\\) decrease by week 12),","confidence":0.9199993421789259,"confidence_rate":0.9991133473094017},{"cnt":[[516,554],[1768,554],[1768,599],[516,599]],"region":{"top_left_x":515,"top_left_y":554,"width":1254,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20168b21ebb7443d8f89fe5a5af5b44c","type":"text","conversion_output":true,"text":"weight loss (e.g., <3\\% decrease by week 12; <5\\% decrease by week 20), and for physical","text_display":" weight loss (e.g., <3\\% decrease by week 12; <5\\% decrease by week 20), and for physical","confidence":0.9365768432617188,"confidence_rate":0.9992802184331169},{"cnt":[[516,602],[1803,602],[1803,647],[516,647]],"region":{"top_left_x":515,"top_left_y":601,"width":1288,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b869002b7b46402b92703e46bce478f5","type":"text","conversion_output":true,"text":"activity (e.g., <150 minutes/week of moderate-intensity physical activity or <8000 steps per","text_display":" activity (e.g., <150 minutes/week of moderate-intensity physical activity or <8000 steps per","confidence":0.9741334915161133,"confidence_rate":0.9997298619599755},{"cnt":[[516,649],[1783,649],[1783,694],[516,694]],"region":{"top_left_x":515,"top_left_y":648,"width":1269,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2437f14a76e3401896ff8120c8c63e78","type":"text","conversion_output":true,"text":"day by week 12). Each week the coach and supervisors will discuss new and flagged cases","text_display":" day by week 12). Each week the coach and supervisors will discuss new and flagged cases","confidence":1,"confidence_rate":1},{"cnt":[[516,700],[1751,700],[1751,746],[516,746]],"region":{"top_left_x":515,"top_left_y":700,"width":1236,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3552b934926e4a4a997ef8d95017a0f1","type":"text","conversion_output":true,"text":"(5-10 minutes of discussion per case). The study psychiatrist and physician will provide","text_display":" (5-10 minutes of discussion per case). The study psychiatrist and physician will provide","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[516,748],[1783,748],[1783,793],[516,793]],"region":{"top_left_x":515,"top_left_y":747,"width":1269,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a07d79d23dc4be0bce0ac8aa116d692","type":"text","conversion_output":true,"text":"psychiatric and medical advice to the coach during case review meetings, but they will not","text_display":" psychiatric and medical advice to the coach during case review meetings, but they will not","confidence":1,"confidence_rate":1},{"cnt":[[516,795],[1777,795],[1777,844],[516,844]],"region":{"top_left_x":515,"top_left_y":794,"width":1262,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bacccebd16d405888b486e4a0898493","type":"text","conversion_output":true,"text":"directly interact with intervention participants. Consistent with stepped care strategies, for","text_display":" directly interact with intervention participants. Consistent with stepped care strategies, for","confidence":1,"confidence_rate":1},{"cnt":[[516,844],[1807,844],[1807,892],[516,892]],"region":{"top_left_x":515,"top_left_y":844,"width":1292,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d59daa9ba38434d8fb37d5d55345ee8","type":"text","conversion_output":true,"text":"patients with unremitting depression symptoms the supervising psychiatrist will recommend","text_display":" patients with unremitting depression symptoms the supervising psychiatrist will recommend","confidence":1,"confidence_rate":1},{"cnt":[[516,894],[1777,894],[1777,939],[516,939]],"region":{"top_left_x":515,"top_left_y":893,"width":1262,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b9d4b462dd3490da83a9644c72fd055","type":"text","conversion_output":true,"text":"antidepressant medication changes, according to the study medication protocol (Appendix","text_display":" antidepressant medication changes, according to the study medication protocol (Appendix","confidence":1,"confidence_rate":1},{"cnt":[[516,941],[1749,941],[1749,988],[516,988]],"region":{"top_left_x":515,"top_left_y":941,"width":1234,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"871d6ed66e6c41c18654336360a780b7","type":"text","conversion_output":true,"text":"A), taking into account potential medical or substance abuse etiologies. The psychiatrist","text_display":" A), taking into account potential medical or substance abuse etiologies. The psychiatrist","confidence":1,"confidence_rate":1},{"cnt":[[516,993],[1721,993],[1721,1038],[516,1038]],"region":{"top_left_x":515,"top_left_y":992,"width":1206,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b10db5e7297c43e68c54c204e08e37c5","type":"text","conversion_output":true,"text":"communicates her recommendations via secure EHR staff messaging to PCPs who, as","text_display":" communicates her recommendations via secure EHR staff messaging to PCPs who, as","confidence":1,"confidence_rate":1},{"cnt":[[516,1040],[1747,1040],[1747,1085],[516,1085]],"region":{"top_left_x":515,"top_left_y":1039,"width":1232,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4da0421c75e4147bfa58c9c0644a696","type":"text","conversion_output":true,"text":"treating physicians, will be responsible for prescribing the recommended antidepressant","text_display":" treating physicians, will be responsible for prescribing the recommended antidepressant","confidence":1,"confidence_rate":1},{"cnt":[[516,1087],[1725,1087],[1725,1137],[516,1137]],"region":{"top_left_x":515,"top_left_y":1087,"width":1211,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c66b5f7f25e746b4b6ae666c8cac07f9","type":"text","conversion_output":true,"text":"medications. PCPs may consult the study psychiatrist if they have questions about any","text_display":" medications. PCPs may consult the study psychiatrist if they have questions about any","confidence":1,"confidence_rate":1},{"cnt":[[516,1139],[1738,1139],[1738,1184],[516,1184]],"region":{"top_left_x":515,"top_left_y":1138,"width":1224,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"033fd5d5c6814c658d3824936f39e0e6","type":"text","conversion_output":true,"text":"recommended medication changes. The coach will monitor condition status, coordinate","text_display":" recommended medication changes. The coach will monitor condition status, coordinate","confidence":1,"confidence_rate":1},{"cnt":[[516,1182],[1706,1182],[1706,1231],[516,1231]],"region":{"top_left_x":515,"top_left_y":1181,"width":1191,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"413858fb812a4530b403f53e223815e2","type":"text","conversion_output":true,"text":"communication between the supervising psychiatrist and the patient's PCP regarding","text_display":" communication between the supervising psychiatrist and the patient's PCP regarding","confidence":1,"confidence_rate":1},{"cnt":[[516,1233],[1706,1233],[1706,1283],[516,1283]],"region":{"top_left_x":515,"top_left_y":1233,"width":1191,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f688ae60ac0f4f54b02868ec62d46c26","type":"text","conversion_output":true,"text":"medication changes, and help problem solve barriers to medication adherence during","text_display":" medication changes, and help problem solve barriers to medication adherence during","confidence":1,"confidence_rate":1},{"cnt":[[516,1280],[754,1280],[754,1326],[516,1326]],"region":{"top_left_x":515,"top_left_y":1280,"width":240,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ace7b8b418604451a8122d76db4daa89","type":"text","conversion_output":true,"text":"scheduled visits.","text_display":" scheduled visits.","confidence":1,"confidence_rate":1},{"cnt":[[301,1369],[681,1369],[681,1424],[301,1424]],"region":{"top_left_x":300,"top_left_y":1368,"width":382,"height":57},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d5f27c24aac4b1d920af9501b672f58","type":"section_header","conversion_output":false,"children_ids":["6bcdb42f2b1a4687bcae8fc04d20589b"],"text":"","text_display":""},{"cnt":[[305,1375],[677,1375],[677,1420],[305,1420]],"region":{"top_left_x":305,"top_left_y":1375,"width":372,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bcdb42f2b1a4687bcae8fc04d20589b","type":"text","conversion_output":true,"parent_id":"7d5f27c24aac4b1d920af9501b672f58","text":"2.7. Participant Safety","text_display":"\n\n\\subsection*{2.7. 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During screening women who are pregnant,","text_display":" assessments and before randomization. During screening women who are pregnant,","confidence":1,"confidence_rate":1},{"cnt":[[516,1629],[1738,1629],[1738,1678],[516,1678]],"region":{"top_left_x":515,"top_left_y":1628,"width":1224,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"886cf47ddf5a4dc0ad3ffa657cebef21","type":"text","conversion_output":true,"text":"lactating, or planning to become pregnant during the study period will be excluded. If a","text_display":" lactating, or planning to become pregnant during the study period will be excluded. If a","confidence":1,"confidence_rate":1},{"cnt":[[516,1678],[1652,1678],[1652,1725],[516,1725]],"region":{"top_left_x":515,"top_left_y":1677,"width":1138,"height":49},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e63037f33af462d86c26fcfda255776","type":"text","conversion_output":true,"text":"participant becomes pregnant during the study, she will be excluded from further","text_display":" participant becomes pregnant during the study, she will be excluded from further","confidence":1,"confidence_rate":1},{"cnt":[[516,1727],[1712,1727],[1712,1775],[516,1775]],"region":{"top_left_x":515,"top_left_y":1727,"width":1198,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88e2a972ad4c4ce6846ae5e9abf82f4b","type":"text","conversion_output":true,"text":"participation in all study activities, and her PCP will be notified. 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Participants who are","confidence":1,"confidence_rate":1},{"cnt":[[516,1775],[1710,1775],[1710,1824],[516,1824]],"region":{"top_left_x":515,"top_left_y":1774,"width":1196,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a09316dd2f548a398a60837f5414295","type":"text","conversion_output":true,"text":"diagnosed with any other exclusionary condition (e.g., coronary heart disease, stroke,","text_display":" diagnosed with any other exclusionary condition (e.g., coronary heart disease, stroke,","confidence":1,"confidence_rate":1},{"cnt":[[516,1824],[1807,1824],[1807,1871],[516,1871]],"region":{"top_left_x":515,"top_left_y":1824,"width":1292,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7e155ed5205483290b2c812a8f30eb9","type":"text","conversion_output":true,"text":"diabetes, and cancer) following randomization may continue in the trial with approval of the","text_display":" diabetes, and cancer) following randomization may continue in the trial with approval of the","confidence":1,"confidence_rate":1},{"cnt":[[516,1873],[1785,1873],[1785,1919],[516,1919]],"region":{"top_left_x":515,"top_left_y":1873,"width":1271,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"206a3bdf7c5c48f39f7469ae6588ef45","type":"text","conversion_output":true,"text":"study physician. Established alert levels (e.g., for high blood pressure) and alert conditions","text_display":" study physician. Established alert levels (e.g., for high blood pressure) and alert conditions","confidence":1,"confidence_rate":1},{"cnt":[[516,1921],[1781,1921],[1781,1970],[516,1970]],"region":{"top_left_x":515,"top_left_y":1920,"width":1267,"height":51},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68586152f8004840bf69cec97f14dd78","type":"text","conversion_output":true,"text":"(e.g., suicidality, angina, and peripheral vascular disease) will help ensure that participants","text_display":" (e.g., suicidality, angina, and peripheral vascular disease) will help ensure that participants","confidence":1,"confidence_rate":1},{"cnt":[[516,1970],[1811,1970],[1811,2017],[516,2017]],"region":{"top_left_x":515,"top_left_y":1970,"width":1297,"height":48},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4860c9d0548d4874b075226468ec7c08","type":"text","conversion_output":true,"text":"are referred for further evaluation and therapy when clinically indicated. The PHQ-9 and the","text_display":" are referred for further evaluation and therapy when clinically indicated. The PHQ-9 and the","confidence":1,"confidence_rate":1},{"cnt":[[516,2020],[1792,2020],[1792,2065],[516,2065]],"region":{"top_left_x":515,"top_left_y":2019,"width":1277,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09a205e0791948feb355cab37b3be7c1","type":"text","conversion_output":true,"text":"SCL-20 will be used to assess suicidal risk. Study staff will follow the self-harm protection","text_display":" SCL-20 will be used to assess suicidal risk. Study staff will follow the self-harm protection","confidence":0.9990236759185791,"confidence_rate":0.9999900326925697},{"cnt":[[516,2067],[1725,2067],[1725,2116],[516,2116]],"region":{"top_left_x":515,"top_left_y":2066,"width":1211,"height":51},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bde0d82aa193441a908dfcdfe287b714","type":"text","conversion_output":true,"text":"protocol (Appendix B) if a participant responds \" 2 \" (\"more than half the days\") or \" 3 \"","text_display":" protocol (Appendix B) if a participant responds \" 2 \" (\"more than half the days\") or \" 3 \"","confidence":0.8812985941767693,"confidence_rate":0.9987497052008771},{"cnt":[[516,2114],[1656,2114],[1656,2163],[516,2163]],"region":{"top_left_x":515,"top_left_y":2114,"width":1142,"height":50},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7589b13c4344fe19ddae84246883d6e","type":"text","conversion_output":true,"text":"(\"nearly every day\") to item 9 of the PHQ- 9 or responds \" 3 \" ('quite a bit\") or \" 4 \"","text_display":" (\"nearly every day\") to item 9 of the PHQ- 9 or responds \" 3 \" ('quite a bit\") or \" 4 \"","confidence":0.5504390873772991,"confidence_rate":0.9942756872627527},{"cnt":[[516,2161],[1068,2161],[1068,2211],[516,2211]],"region":{"top_left_x":515,"top_left_y":2161,"width":553,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"465ae39a24084017b695535c24d1392f","type":"text","conversion_output":true,"text":"(\"extremely\") to item 2 of the SCL-20.","text_display":" (\"extremely\") to item 2 of the SCL-20.","confidence":1,"confidence_rate":1},{"cnt":[[516,2247],[1742,2247],[1742,2297],[516,2297]],"region":{"top_left_x":515,"top_left_y":2247,"width":1228,"height":50},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b393c698dc04ccab4365084586442fe","type":"text","conversion_output":true,"text":"To ensure unbiased ascertainment between the intervention and control group, outcome","text_display":"\n\nTo ensure unbiased ascertainment between the intervention and control group, outcome","confidence":1,"confidence_rate":1},{"cnt":[[516,2295],[1738,2295],[1738,2344],[516,2344]],"region":{"top_left_x":515,"top_left_y":2294,"width":1224,"height":50},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19dae2135749461598017e2e640177cc","type":"text","conversion_output":true,"text":"assessors will systematically screen all participants for adverse events during in-person","text_display":" assessors will systematically screen all participants for adverse events during in-person","confidence":1,"confidence_rate":1},{"cnt":[[516,2346],[1781,2346],[1781,2391],[516,2391]],"region":{"top_left_x":515,"top_left_y":2346,"width":1267,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2abf1cdd14b54d9abc3821018a7090be","type":"text","conversion_output":true,"text":"assessments at baseline, \\(6,12,18\\), and 24 months using a standard interview and reporting","text_display":" assessments at baseline, \\(6,12,18\\), and 24 months using a standard interview and reporting","confidence":0.978590726852417,"confidence_rate":0.9997836056555889},{"cnt":[[554,2479],[1381,2479],[1381,2516],[554,2516]],"region":{"top_left_x":554,"top_left_y":2479,"width":828,"height":37},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"efba8197e5634c7191f57d9fef177f86","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.998046875,"confidence_rate":0.9999746102595223}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-09","page":9,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c80e6255bdd4489f951da6edf41b4fed","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1732,131],[1815,131],[1815,165],[1732,165]],"region":{"top_left_x":1731,"top_left_y":131,"width":85,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8453cd2a81c847b8b3587fe62b81a1da","type":"page_info","conversion_output":false,"text":"Page 9","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[516,206],[1721,206],[1721,256],[516,256]],"region":{"top_left_x":515,"top_left_y":206,"width":1206,"height":50},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04e2ba68cc344eb187d514b525d6677f","type":"text","conversion_output":true,"text":"form as done in our previous trials. \\({ }^{25,30,40}\\) Positive response will be recorded and then","text_display":"\nform as done in our previous trials. \\({ }^{25,30,40}\\) Positive response will be recorded and then","confidence":1,"confidence_rate":1},{"cnt":[[56,251],[118,251],[118,2374],[56,2374]],"region":{"top_left_x":55,"top_left_y":251,"width":64,"height":2124},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"213c4410a3374b2fb9680f3ea6594344","type":"rotated_container","conversion_output":false,"children_ids":["a40d6308075a437b9692987c7354d16e"],"text":"","text_display":""},{"cnt":[[59,251],[114,251],[114,2371],[59,2371]],"region":{"top_left_x":58,"top_left_y":251,"width":56,"height":2120},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a40d6308075a437b9692987c7354d16e","type":"table","conversion_output":true,"parent_id":"213c4410a3374b2fb9680f3ea6594344","text":"Author Manuscript Author Manuscript Author Manuscript Author Manuscript","text_display":"\n\nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript","confidence":0.9980480668600649,"confidence_rate":0.9999742919009319},{"cnt":[[516,262],[1815,262],[1815,305],[516,305]],"region":{"top_left_x":515,"top_left_y":262,"width":1301,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac7047821660403291d76209240ee832","type":"text","conversion_output":true,"text":"reviewed by the study safety officer for seriousness, study relatedness, and expectedness. An","text_display":"\nreviewed by the study safety officer for seriousness, study relatedness, and expectedness. An","confidence":1,"confidence_rate":1},{"cnt":[[516,312],[1781,312],[1781,354],[516,354]],"region":{"top_left_x":515,"top_left_y":311,"width":1267,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4eb7a51493e447b8fc7db22925255e5","type":"text","conversion_output":true,"text":"adverse event is defined as any untoward medical or psychological event experienced by a","text_display":" adverse event is defined as any untoward medical or psychological event experienced by a","confidence":1,"confidence_rate":1},{"cnt":[[516,361],[1699,361],[1699,402],[516,402]],"region":{"top_left_x":515,"top_left_y":360,"width":1185,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f300694d5315438a85ec9df9edc865e4","type":"text","conversion_output":true,"text":"patient during or as a result of his/her participation in the study that represents a new","text_display":" patient during or as a result of his/her participation in the study that represents a new","confidence":1,"confidence_rate":1},{"cnt":[[518,408],[1721,408],[1721,449],[518,449]],"region":{"top_left_x":517,"top_left_y":408,"width":1204,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2674b9f4b7d4707841a7392bd3483dc","type":"text","conversion_output":true,"text":"symptom or an exacerbation of an existing condition, whether or not considered study","text_display":" symptom or an exacerbation of an existing condition, whether or not considered study","confidence":1,"confidence_rate":1},{"cnt":[[516,458],[1732,458],[1732,501],[516,501]],"region":{"top_left_x":515,"top_left_y":457,"width":1217,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b33fb7ac81804c1ab74b6e3885b3931d","type":"text","conversion_output":true,"text":"related based on appropriate medical judgment. Documentation in EHR will be used to","text_display":" related based on appropriate medical judgment. Documentation in EHR will be used to","confidence":1,"confidence_rate":1},{"cnt":[[516,507],[1740,507],[1740,548],[516,548]],"region":{"top_left_x":515,"top_left_y":507,"width":1226,"height":41},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5bf5aa3cc4b423ca1f8cfa7d743f473","type":"text","conversion_output":true,"text":"verify patient self-reports. Adverse events discovered outside these planned evaluations","text_display":" verify patient self-reports. Adverse events discovered outside these planned evaluations","confidence":1,"confidence_rate":1},{"cnt":[[516,554],[1803,554],[1803,595],[516,595]],"region":{"top_left_x":515,"top_left_y":554,"width":1288,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7bdc35a1059469b88902c30497c98a6","type":"text","conversion_output":true,"text":"(e.g., during intervention encounters) will be duly noted and followed up with, as needed, to","text_display":" (e.g., during intervention encounters) will be duly noted and followed up with, as needed, to","confidence":1,"confidence_rate":1},{"cnt":[[516,604],[1742,604],[1742,647],[516,647]],"region":{"top_left_x":515,"top_left_y":603,"width":1228,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06226be3f8de4b41ab02c43ef66d533a","type":"text","conversion_output":true,"text":"assure participant safety. We will report adverse events according to the data and safety","text_display":" assure participant safety. We will report adverse events according to the data and safety","confidence":1,"confidence_rate":1},{"cnt":[[516,649],[956,649],[956,694],[516,694]],"region":{"top_left_x":515,"top_left_y":648,"width":442,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94dfb865c7354684ac93fe243b33b174","type":"text","conversion_output":true,"text":"monitoring plan (Appendix C).","text_display":" monitoring plan (Appendix C).","confidence":1,"confidence_rate":1},{"cnt":[[305,739],[546,739],[546,784],[305,784]],"region":{"top_left_x":305,"top_left_y":739,"width":241,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2f3a4e573d14e098125a4f050a0b7a6","type":"section_header","conversion_output":false,"children_ids":["a6958c8b0b8c4c359434d41845adfcf5"],"text":"","text_display":""},{"cnt":[[309,743],[544,743],[544,780],[309,780]],"region":{"top_left_x":309,"top_left_y":743,"width":235,"height":37},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6958c8b0b8c4c359434d41845adfcf5","type":"text","conversion_output":true,"parent_id":"e2f3a4e573d14e098125a4f050a0b7a6","text":"2.8. Retention","text_display":"\n\n\\subsection*{2.8. Retention}","confidence":0.9951171875,"confidence_rate":0.9997424135823042},{"cnt":[[518,799],[1794,799],[1794,846],[518,846]],"region":{"top_left_x":517,"top_left_y":799,"width":1277,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0da39b22fba04c819966b2857626a9c0","type":"text","conversion_output":true,"text":"As we have done in our previous trials, \\({ }^{24,25,30,40}\\) we will implement a series of strategies to","text_display":"\n\nAs we have done in our previous trials, \\({ }^{24,25,30,40}\\) we will implement a series of strategies to","confidence":0.9462890625,"confidence_rate":0.9994982423433266},{"cnt":[[518,853],[1738,853],[1738,896],[518,896]],"region":{"top_left_x":517,"top_left_y":852,"width":1222,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49d89be4448648d18a213f1f10815d0b","type":"text","conversion_output":true,"text":"minimize loss to follow-up: (1) careful staff selection and standardized training in trial-","text_display":" minimize loss to follow-up: (1) careful staff selection and standardized training in trial","confidence":1,"confidence_rate":1},{"cnt":[[518,902],[1729,902],[1729,943],[518,943]],"region":{"top_left_x":517,"top_left_y":902,"width":1213,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"177ee1f3837d4422b6aff7629e9a3682","type":"text","conversion_output":true,"text":"specific protocols, rapport building, motivational interviewing, and problem solving as","text_display":"specific protocols, rapport building, motivational interviewing, and problem solving as","confidence":1,"confidence_rate":1},{"cnt":[[518,950],[1693,950],[1693,993],[518,993]],"region":{"top_left_x":517,"top_left_y":949,"width":1176,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf246cd483ef4a8d81cfeaca4c62a4e7","type":"text","conversion_output":true,"text":"appropriate to their study roles; (2) legally adequate, effective informed consent; (3)","text_display":" appropriate to their study roles; (2) legally adequate, effective informed consent; (3)","confidence":0.9990236759185791,"confidence_rate":0.9999893826542317},{"cnt":[[518,999],[1721,999],[1721,1042],[518,1042]],"region":{"top_left_x":517,"top_left_y":999,"width":1204,"height":43},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dea363cc4baa4d799066c137622613c2","type":"text","conversion_output":true,"text":"education of participants about the importance of follow-up assessments regardless of","text_display":" education of participants about the importance of follow-up assessments regardless of","confidence":1,"confidence_rate":1},{"cnt":[[516,1048],[1790,1048],[1790,1089],[516,1089]],"region":{"top_left_x":515,"top_left_y":1048,"width":1275,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72ac67148ce44982be3517c28963985a","type":"text","conversion_output":true,"text":"treatment adherence; (4) prudent participant incentives (e.g., pedometer, cash incentives of","text_display":" treatment adherence; (4) prudent participant incentives (e.g., pedometer, cash incentives of","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[518,1096],[1777,1096],[1777,1137],[518,1137]],"region":{"top_left_x":517,"top_left_y":1095,"width":1260,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"818ac2070c2741559e3f3f75a9022cb2","type":"text","conversion_output":true,"text":"\\(\\$ 20\\) ) and flexible scheduling (outside of work hours, multiple locations); (5) promotion of","text_display":" \\(\\$ 20\\) ) and flexible scheduling (outside of work hours, multiple locations); (5) promotion of","confidence":0.9631056618720777,"confidence_rate":0.9996043714223406},{"cnt":[[518,1145],[1807,1145],[1807,1188],[518,1188]],"region":{"top_left_x":517,"top_left_y":1145,"width":1290,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cab5cdcc547544de8ebf6afb3dbde499","type":"text","conversion_output":true,"text":"study \"brand\" identity with a logo and a website; (6) ongoing monitoring of recruitment and","text_display":" study \"brand\" identity with a logo and a website; (6) ongoing monitoring of recruitment and","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[516,1195],[1757,1195],[1757,1235],[516,1235]],"region":{"top_left_x":515,"top_left_y":1194,"width":1243,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b561e8b5d0f4cb6a1f5f5333ed91143","type":"text","conversion_output":true,"text":"retention; (7) up-to-date participant contact information and two emergency contacts; (8)","text_display":" retention; (7) up-to-date participant contact information and two emergency contacts; (8)","confidence":1,"confidence_rate":1},{"cnt":[[516,1242],[1749,1242],[1749,1283],[516,1283]],"region":{"top_left_x":515,"top_left_y":1241,"width":1234,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"954d527c330c4c9bb0de1534ac69c515","type":"text","conversion_output":true,"text":"diligent efforts to re-engage inactive participants; and (9) alternative means of obtaining","text_display":" diligent efforts to re-engage inactive participants; and (9) alternative means of obtaining","confidence":1,"confidence_rate":1},{"cnt":[[516,1293],[728,1293],[728,1326],[516,1326]],"region":{"top_left_x":515,"top_left_y":1293,"width":214,"height":33},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30c9f1f49f524001b00ae673f4421e4d","type":"text","conversion_output":true,"text":"measurements.","text_display":" measurements.","confidence":1,"confidence_rate":1},{"cnt":[[305,1377],[1291,1377],[1291,1429],[305,1429]],"region":{"top_left_x":305,"top_left_y":1377,"width":987,"height":52},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2042331d66824d848ba1d2a8aebc7b39","type":"section_header","conversion_output":false,"children_ids":["27beb46f406046aab6c29aa7a2882e0c"],"text":"","text_display":""},{"cnt":[[305,1379],[1287,1379],[1287,1424],[305,1424]],"region":{"top_left_x":305,"top_left_y":1379,"width":982,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27beb46f406046aab6c29aa7a2882e0c","type":"text","conversion_output":true,"parent_id":"2042331d66824d848ba1d2a8aebc7b39","text":"2.9. 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BMI will be calculated based on height and weight measured per","text_display":" score at 12 months. 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Additional secondary outcome measures will include depression treatment","confidence":1,"confidence_rate":1},{"cnt":[[516,1878],[1811,1878],[1811,1919],[516,1919]],"region":{"top_left_x":515,"top_left_y":1877,"width":1297,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86e718d089e24d3abdae0af856a8f08f","type":"text","conversion_output":true,"text":"response (>50\\% decline in SCL-20 score from baseline) and remission (SCL-20 score<0.5),","text_display":" response (>50\\% decline in SCL-20 score from baseline) and remission (SCL-20 score<0.5),","confidence":0.8599445755826309,"confidence_rate":0.9983612644262065},{"cnt":[[516,1921],[1779,1921],[1779,1966],[516,1966]],"region":{"top_left_x":515,"top_left_y":1920,"width":1264,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e08b8ff840fc459f90ccd0515a18e41d","type":"text","conversion_output":true,"text":"waist circumference and resting blood pressure according to standardized protocols, \\({ }^{41}\\) and","text_display":" waist circumference and resting blood pressure according to standardized protocols, \\({ }^{41}\\) and","confidence":0.71240234375,"confidence_rate":0.9967755674213866},{"cnt":[[516,1972],[1145,1972],[1145,2015],[516,2015]],"region":{"top_left_x":515,"top_left_y":1972,"width":631,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6162def9f14549ed8b600db639685d0c","type":"text","conversion_output":true,"text":"the following measures at 12 and 24 months:","text_display":" the following measures at 12 and 24 months:","confidence":0.9970703125,"confidence_rate":0.9999456683753719},{"cnt":[[516,2065],[1783,2065],[1783,2108],[516,2108]],"region":{"top_left_x":515,"top_left_y":2064,"width":1269,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bff00d1356948879c0de6f0c4e84542","type":"text","conversion_output":true,"text":"Obesity-specific problems: The Obesity-Related Problem Scale specifically measures the","text_display":"\n\nObesity-specific problems: The Obesity-Related Problem Scale specifically measures the","confidence":1,"confidence_rate":1},{"cnt":[[516,2110],[1798,2110],[1798,2155],[516,2155]],"region":{"top_left_x":515,"top_left_y":2109,"width":1284,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59a6809091c04b9dba069fd7549ac974","type":"text","conversion_output":true,"text":"impact of obesity on psychosocial functioning. The 8-item scale has high internal reliability","text_display":" impact of obesity on psychosocial functioning. The 8-item scale has high internal reliability","confidence":0.51953125,"confidence_rate":0.9933403528040887},{"cnt":[[516,2161],[1815,2161],[1815,2202],[516,2202]],"region":{"top_left_x":515,"top_left_y":2161,"width":1301,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"398031fc0c094d76a3cb39d0e7b4f4e3","type":"text","conversion_output":true,"text":"and sound test-retest reliability, correlates strongly with a wide range of theoretically related","text_display":" and sound test-retest reliability, correlates strongly with a wide range of theoretically related","confidence":1,"confidence_rate":1},{"cnt":[[516,2204],[1336,2204],[1336,2254],[516,2254]],"region":{"top_left_x":515,"top_left_y":2204,"width":822,"height":50},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bc05525a174436c96e0f5aa2306bf44","type":"text","conversion_output":true,"text":"constructs, and is responsive to weight loss intervention. \\({ }^{44}\\)","text_display":" constructs, and is responsive to weight loss intervention. \\({ }^{44}\\)","confidence":0.98779296875,"confidence_rate":0.9998294291462007},{"cnt":[[516,2299],[1785,2299],[1785,2344],[516,2344]],"region":{"top_left_x":515,"top_left_y":2298,"width":1271,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a35da611c804e98ac2b55750b452a7b","type":"text","conversion_output":true,"text":"Anxiety: Anxiety will be measured with the Generalized Anxiety Disorder Scale (GAD-7)","text_display":"\n\nAnxiety: Anxiety will be measured with the Generalized Anxiety Disorder Scale (GAD-7)","confidence":1,"confidence_rate":1},{"cnt":[[516,2350],[1699,2350],[1699,2391],[516,2391]],"region":{"top_left_x":515,"top_left_y":2350,"width":1185,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fecd222a29f14c9f9b4ce5ffa2b77288","type":"text","conversion_output":true,"text":"and the Panic Disorder module of the Mini-International Neuropsychiatric Interview","text_display":" and the Panic Disorder module of the Mini-International Neuropsychiatric Interview","confidence":1,"confidence_rate":1},{"cnt":[[556,2479],[1381,2479],[1381,2516],[556,2516]],"region":{"top_left_x":556,"top_left_y":2479,"width":826,"height":37},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4cdcba74245c494a9f1f06c835aa6cca","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.99462890625,"confidence_rate":0.9999300599792602}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-10","page":10,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"45734e3d693e4870973510111f0a9f8f","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,133],[1815,133],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":133,"width":98,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"87d314d736e14ff6bd21269572439edf","type":"page_info","conversion_output":false,"text":"Page 10","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[511,215],[1760,215],[1760,256],[511,256]],"region":{"top_left_x":511,"top_left_y":214,"width":1249,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7172e5cd9dd14a959f0f773f61f1ca74","type":"text","conversion_output":true,"text":"(MINI). GAD-7 is a valid and reliable 7-question scale for screening generalized anxiety","text_display":"\n(MINI). 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\\({ }^{46}\\) and in the present study we will specifically","text_display":" MINI has high validity and reliability scores; \\({ }^{46}\\) and in the present study we will specifically","confidence":1,"confidence_rate":1},{"cnt":[[516,357],[1111,357],[1111,402],[516,402]],"region":{"top_left_x":515,"top_left_y":356,"width":596,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"237ebf9701b84c77b90d7736eaa95574","type":"text","conversion_output":true,"text":"use module E to screen for panic disorder.","text_display":" use module E to screen for panic disorder.","confidence":1,"confidence_rate":1},{"cnt":[[516,451],[1687,451],[1687,494],[516,494]],"region":{"top_left_x":515,"top_left_y":451,"width":1172,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9520ef7eea6c40e1a2a784cf82c60b70","type":"text","conversion_output":true,"text":"Disability: The Sheehan Disability Scale is a validated questionnaire that measures","text_display":"\n\nDisability: The Sheehan Disability Scale is a validated questionnaire that measures","confidence":1,"confidence_rate":1},{"cnt":[[516,494],[1794,494],[1794,544],[516,544]],"region":{"top_left_x":515,"top_left_y":494,"width":1279,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c6ffe49cf7243ba943f392b4e1c42e3","type":"text","conversion_output":true,"text":"functional disability and is sensitive to treatment effects in clinical trials. \\({ }^{47}\\) Patients rate the","text_display":" functional disability and is sensitive to treatment effects in clinical trials. \\({ }^{47}\\) Patients rate the","confidence":1,"confidence_rate":1},{"cnt":[[516,546],[1721,546],[1721,591],[516,591]],"region":{"top_left_x":515,"top_left_y":545,"width":1206,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1647c2f60612444ba6bc72fc213ad62c","type":"text","conversion_output":true,"text":"extent to which they symptoms impair work/school, social, and family life on a visual","text_display":" extent to which they symptoms impair work/school, social, and family life on a visual","confidence":1,"confidence_rate":1},{"cnt":[[516,597],[1790,597],[1790,640],[516,640]],"region":{"top_left_x":515,"top_left_y":597,"width":1275,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9749d8106624be1bf10dbd335b3158e","type":"text","conversion_output":true,"text":"analog scale from 0 to 10 and answer the number of days when their symptoms cause them","text_display":" analog scale from 0 to 10 and answer the number of days when their symptoms cause them","confidence":1,"confidence_rate":1},{"cnt":[[516,645],[1319,645],[1319,690],[516,690]],"region":{"top_left_x":515,"top_left_y":644,"width":805,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5580a2b703c544039bec4cddb5e37b67","type":"text","conversion_output":true,"text":"to miss work/school and be unproductive at work/school.","text_display":" to miss work/school and be unproductive at work/school.","confidence":1,"confidence_rate":1},{"cnt":[[516,735],[1721,735],[1721,780],[516,780]],"region":{"top_left_x":515,"top_left_y":734,"width":1206,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02875c401bd34ab7b74514c8fa7acf2d","type":"text","conversion_output":true,"text":"Quality of life: Quality of life will be measured with the Short Form-8 Health Survey","text_display":"\n\nQuality of life: Quality of life will be measured with the Short Form-8 Health Survey","confidence":0.9658203125,"confidence_rate":0.9996136582716735},{"cnt":[[518,784],[1794,784],[1794,827],[518,827]],"region":{"top_left_x":517,"top_left_y":784,"width":1277,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02006fada6674480b70058e345fa0a09","type":"text","conversion_output":true,"text":"(SF-8) and Euro-QoL 5D. 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It has been shown to be a valid and reliable tool to measure","text_display":" analogue scale from 0 to 100 . 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Direct medical costs","text_display":"\n\nCosts: These include direct medical costs and direct nonmedical costs. 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We","text_display":" utilization (e.g., office visits, in-patient stays, procedures, medications, laboratory tests). We","confidence":1,"confidence_rate":1},{"cnt":[[516,1508],[1747,1508],[1747,1551],[516,1551]],"region":{"top_left_x":515,"top_left_y":1508,"width":1232,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a15e4164699c49a6ab91fae8665a7d18","type":"text","conversion_output":true,"text":"will also interview participants about their medication use (with the aid of containers of","text_display":" will also interview participants about their medication use (with the aid of containers of","confidence":1,"confidence_rate":1},{"cnt":[[516,1555],[1768,1555],[1768,1601],[516,1601]],"region":{"top_left_x":515,"top_left_y":1555,"width":1254,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78815b114f6d46e3969c46cc8cea6034","type":"text","conversion_output":true,"text":"regularly-taken medication brought by participants to the visits), general wellness service","text_display":" regularly-taken medication brought by participants to the visits), general wellness service","confidence":1,"confidence_rate":1},{"cnt":[[516,1605],[1783,1605],[1783,1648],[516,1648]],"region":{"top_left_x":515,"top_left_y":1604,"width":1269,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d4e524c35114b5ba0619f0dde02a564","type":"text","conversion_output":true,"text":"use, and out of network health care utilization. Also, we will survey the coach and patients","text_display":" use, and out of network health care utilization. Also, we will survey the coach and patients","confidence":1,"confidence_rate":1},{"cnt":[[516,1652],[1712,1652],[1712,1695],[516,1695]],"region":{"top_left_x":515,"top_left_y":1652,"width":1198,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20d67bf3a0e149fda05705fb77bdd377","type":"text","conversion_output":true,"text":"using adapted resource utilization and cost capture instruments based on the Diabetes","text_display":" using adapted resource utilization and cost capture instruments based on the Diabetes","confidence":1,"confidence_rate":1},{"cnt":[[516,1695],[1583,1695],[1583,1745],[516,1745]],"region":{"top_left_x":515,"top_left_y":1695,"width":1069,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d23a6ed98ae4c6c8c324c5d1c01f2ca","type":"text","conversion_output":true,"text":"Prevention Program and Diabetes Prevention Program translation trials. \\({ }^{50,51}\\)","text_display":" Prevention Program and Diabetes Prevention Program translation trials. \\({ }^{50,51}\\)","confidence":0.6767126120394096,"confidence_rate":0.9955214541512375},{"cnt":[[516,1792],[1768,1792],[1768,1837],[516,1837]],"region":{"top_left_x":515,"top_left_y":1791,"width":1254,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b96d940bcb564699a1d377b2c6108e69","type":"text","conversion_output":true,"text":"2.9.3. Potential effect modifiers and mediators-To complement the primary and","text_display":"\n2.9.3. Potential effect modifiers and mediators-To complement the primary and","confidence":0.8298373222351074,"confidence_rate":0.9977278828004121},{"cnt":[[516,1841],[1781,1841],[1781,1884],[516,1884]],"region":{"top_left_x":515,"top_left_y":1841,"width":1267,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2da25dbb77a54662a98db55a9c54aa08","type":"text","conversion_output":true,"text":"secondary findings, we will explore for whom and under what condition (effect modifiers)","text_display":" secondary findings, we will explore for whom and under what condition (effect modifiers)","confidence":1,"confidence_rate":1},{"cnt":[[516,1891],[1811,1891],[1811,1931],[516,1931]],"region":{"top_left_x":515,"top_left_y":1890,"width":1297,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6b2462d747a4fbf9e07c1a7afc3183a","type":"text","conversion_output":true,"text":"and how (mediators) treatment effects occur. Data will be collected on measures of potential","text_display":" and how (mediators) treatment effects occur. Data will be collected on measures of potential","confidence":1,"confidence_rate":1},{"cnt":[[516,1938],[1772,1938],[1772,1983],[516,1983]],"region":{"top_left_x":515,"top_left_y":1937,"width":1258,"height":47},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8808de996c1149fe8b3b74a8b8d28349","type":"text","conversion_output":true,"text":"moderators (e.g., gender, age, race/ethnicity, education, posttraumatic stress disorder) and","text_display":" moderators (e.g., gender, age, race/ethnicity, education, posttraumatic stress disorder) and","confidence":1,"confidence_rate":1},{"cnt":[[516,1989],[1687,1989],[1687,2030],[516,2030]],"region":{"top_left_x":515,"top_left_y":1989,"width":1172,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52db9edf1a6343328905e42275b13921","type":"text","conversion_output":true,"text":"mediators (e.g. dietary intake, physical activity, problem solving, and sleep quality)","text_display":" mediators (e.g. dietary intake, physical activity, problem solving, and sleep quality)","confidence":1,"confidence_rate":1},{"cnt":[[516,2037],[1772,2037],[1772,2078],[516,2078]],"region":{"top_left_x":515,"top_left_y":2036,"width":1258,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"302794b7c79a4d4ab3471d4e4311b3a7","type":"text","conversion_output":true,"text":"responses to the intervention. Posttraumatic stress disorder (PTSD) will be measured with","text_display":" responses to the intervention. Posttraumatic stress disorder (PTSD) will be measured with","confidence":1,"confidence_rate":1},{"cnt":[[516,2080],[1717,2080],[1717,2129],[516,2129]],"region":{"top_left_x":515,"top_left_y":2079,"width":1202,"height":51},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fa59341148a4232860328ac413fd47c","type":"text","conversion_output":true,"text":"the 17-item PTSD checklist - Civilian Version that has high reliability and validity. \\({ }^{52}\\)","text_display":" the 17-item PTSD checklist - Civilian Version that has high reliability and validity. \\({ }^{52}\\)","confidence":0.37032508850097656,"confidence_rate":0.9900160922104311},{"cnt":[[516,2127],[1738,2127],[1738,2176],[516,2176]],"region":{"top_left_x":515,"top_left_y":2126,"width":1224,"height":51},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb458696b5664e5b87e2fd8b08c8aef6","type":"text","conversion_output":true,"text":"Participants' dietary intake will be assessed by multiple-pass 24 -hour diet recalls, \\({ }^{53}\\) the","text_display":" Participants' dietary intake will be assessed by multiple-pass 24 -hour diet recalls, \\({ }^{53}\\) the","confidence":0.8540039409417659,"confidence_rate":0.9985663062629745},{"cnt":[[516,2179],[1807,2179],[1807,2226],[516,2226]],"region":{"top_left_x":515,"top_left_y":2178,"width":1292,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cb0d383046f49d6ac8d4f2dfeb9a346","type":"text","conversion_output":true,"text":"gold-standard dietary assessment method. Physical activity will be measured using Stanford","text_display":" gold-standard dietary assessment method. Physical activity will be measured using Stanford","confidence":1,"confidence_rate":1},{"cnt":[[516,2230],[1749,2230],[1749,2275],[516,2275]],"region":{"top_left_x":515,"top_left_y":2230,"width":1234,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3065acb3dd3546cc9c8e01d5d7b350a9","type":"text","conversion_output":true,"text":"7-day Physical Activity Recall, which is a reliable measure that is sensitive to change in","text_display":" 7-day Physical Activity Recall, which is a reliable measure that is sensitive to change in","confidence":1,"confidence_rate":1},{"cnt":[[516,2273],[1772,2273],[1772,2322],[516,2322]],"region":{"top_left_x":515,"top_left_y":2273,"width":1258,"height":50},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18a71478e7ca44b0b662799d5337fe60","type":"text","conversion_output":true,"text":"physical activity. \\({ }^{54}\\) Participants' problem solving skills will be assessed using the reliable","text_display":" physical activity. \\({ }^{54}\\) Participants' problem solving skills will be assessed using the reliable","confidence":1,"confidence_rate":1},{"cnt":[[516,2329],[1790,2329],[1790,2374],[516,2374]],"region":{"top_left_x":515,"top_left_y":2328,"width":1275,"height":47},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2adae1eafaca4467bbcc667df62f38ab","type":"text","conversion_output":true,"text":"and valid Social Problem-Solving Inventory-Revised: Short Form that contains 25 items in","text_display":" and valid Social Problem-Solving Inventory-Revised: Short Form that contains 25 items in","confidence":0.99951171875,"confidence_rate":0.9999949125077527},{"cnt":[[559,2479],[1381,2479],[1381,2516],[559,2516]],"region":{"top_left_x":558,"top_left_y":2479,"width":824,"height":37},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7dedc79c1d7f477c852ff289110ca997","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-11","page":11,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"397d584366e344c083036b60f20df67b","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,133],[1815,133],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":133,"width":98,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"343a257e8e1a46c79df983303db27884","type":"page_info","conversion_output":false,"text":"Page 11","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[511,215],[1772,215],[1772,256],[511,256]],"region":{"top_left_x":511,"top_left_y":214,"width":1262,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bf3410ce1094162bb924a61caef53f4","type":"text","conversion_output":true,"text":"the following five scales: positive problem orientation, rational problem solving, negative","text_display":"\nthe following five scales: positive problem orientation, rational problem solving, negative","confidence":1,"confidence_rate":1},{"cnt":[[56,254],[118,254],[118,2374],[56,2374]],"region":{"top_left_x":55,"top_left_y":253,"width":64,"height":2122},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b7dea26c6e3433298a74f6fe247be9d","type":"rotated_container","conversion_output":false,"children_ids":["eda30e82e3bf4db39d651511b22927f8"],"text":"","text_display":""},{"cnt":[[59,253],[114,253],[114,2373],[59,2373]],"region":{"top_left_x":58,"top_left_y":253,"width":56,"height":2120},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eda30e82e3bf4db39d651511b22927f8","type":"table","conversion_output":true,"parent_id":"5b7dea26c6e3433298a74f6fe247be9d","text":"Author Manuscript Author Manuscript Author Manuscript Author Manuscript","text_display":"\n\nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript","confidence":0.9970729344058782,"confidence_rate":0.9999614302460895},{"cnt":[[516,258],[1772,258],[1772,307],[516,307]],"region":{"top_left_x":515,"top_left_y":257,"width":1258,"height":51},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1d53fa3c40a4f23904880faf8f64c0c","type":"text","conversion_output":true,"text":"problem orientation, impulsive/careless style, and avoidance style. \\({ }^{55}\\) Sleep quality will be","text_display":"\nproblem orientation, impulsive/careless style, and avoidance style. \\({ }^{55}\\) Sleep quality will be","confidence":1,"confidence_rate":1},{"cnt":[[516,312],[1745,312],[1745,354],[516,354]],"region":{"top_left_x":515,"top_left_y":311,"width":1230,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9408d602302e4fba958c7364fce03e90","type":"text","conversion_output":true,"text":"measured with the 8-item PROMIS sleep disturbance and sleep impairment scales short","text_display":" measured with the 8-item PROMIS sleep disturbance and sleep impairment scales short","confidence":0.9541015625,"confidence_rate":0.9994662203115855},{"cnt":[[516,352],[642,352],[642,397],[516,397]],"region":{"top_left_x":515,"top_left_y":352,"width":128,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8a529771dec4b4fab92113424880435","type":"text","conversion_output":true,"text":"forms. \\({ }^{56}\\)","text_display":" forms. \\({ }^{56}\\)","confidence":1,"confidence_rate":1},{"cnt":[[516,451],[1734,451],[1734,492],[516,492]],"region":{"top_left_x":515,"top_left_y":451,"width":1219,"height":41},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"374b9b7e33e047199cff1e45c664ec89","type":"text","conversion_output":true,"text":"2.9.4. Process measures-As in an effectiveness-and-preliminary-implementation","text_display":"\n2.9.4. Process measures-As in an effectiveness-and-preliminary-implementation","confidence":1,"confidence_rate":1},{"cnt":[[516,501],[1755,501],[1755,544],[516,544]],"region":{"top_left_x":515,"top_left_y":500,"width":1241,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cc7d487d60c447aa8f1ae51256eb240","type":"text","conversion_output":true,"text":"(Type 1 hybrid) design, we will use mixed methods to collect process measures that will","text_display":" (Type 1 hybrid) design, we will use mixed methods to collect process measures that will","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[516,550],[1775,550],[1775,591],[516,591]],"region":{"top_left_x":515,"top_left_y":550,"width":1260,"height":41},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a4500edd0694b85832b1eb5379220bb","type":"text","conversion_output":true,"text":"provide a nuanced understanding of why the intervention is (or is not) more effective than","text_display":" provide a nuanced understanding of why the intervention is (or is not) more effective than","confidence":1,"confidence_rate":1},{"cnt":[[516,597],[1775,597],[1775,638],[516,638]],"region":{"top_left_x":515,"top_left_y":597,"width":1260,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b99ae8bf7dec4bf8a9c2c90ce99c63c7","type":"text","conversion_output":true,"text":"usual care, whether high intervention fidelity is achieved, what barriers and enablers there","text_display":" usual care, whether high intervention fidelity is achieved, what barriers and enablers there","confidence":1,"confidence_rate":1},{"cnt":[[516,645],[1803,645],[1803,688],[516,688]],"region":{"top_left_x":515,"top_left_y":644,"width":1288,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a751b5724b44e3498bbd8a9581aecd5","type":"text","conversion_output":true,"text":"are, how these may translate into real-world implementation, and what modifications can be","text_display":" are, how these may translate into real-world implementation, and what modifications can be","confidence":1,"confidence_rate":1},{"cnt":[[516,690],[1790,690],[1790,737],[516,737]],"region":{"top_left_x":515,"top_left_y":689,"width":1275,"height":48},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4e956ce94ea43e994cf1720a2a4a9b0","type":"text","conversion_output":true,"text":"made to maximize implementation success. \\({ }^{22}\\) We will frame the process evaluation around","text_display":" made to maximize implementation success. \\({ }^{22}\\) We will frame the process evaluation around","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[516,743],[1704,743],[1704,784],[516,784]],"region":{"top_left_x":515,"top_left_y":743,"width":1189,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e2d3d43afdb4299aadb02af4ae17e60","type":"text","conversion_output":true,"text":"the RE-AIM framework (Table 4). In addition to focusing on effectiveness, RE-AIM","text_display":" the RE-AIM framework (Table 4). In addition to focusing on effectiveness, RE-AIM","confidence":1,"confidence_rate":1},{"cnt":[[516,791],[1760,791],[1760,831],[516,831]],"region":{"top_left_x":515,"top_left_y":790,"width":1245,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec64db8e89ac41589cf70f6c45110de0","type":"text","conversion_output":true,"text":"examines the reach, adoption, implementation, and maintenance of the program, and any","text_display":" examines the reach, adoption, implementation, and maintenance of the program, and any","confidence":1,"confidence_rate":1},{"cnt":[[516,834],[1755,834],[1755,883],[516,883]],"region":{"top_left_x":515,"top_left_y":833,"width":1241,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00d937bc707e4786bd79064722e010c2","type":"text","conversion_output":true,"text":"barriers or enablers in each of these domains. \\({ }^{57,58}\\) We will conduct survey and interview","text_display":" barriers or enablers in each of these domains. \\({ }^{57,58}\\) We will conduct survey and interview","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[516,889],[1755,889],[1755,930],[516,930]],"region":{"top_left_x":515,"top_left_y":889,"width":1241,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ac16ad68c4648f1b839e5a6a67e818f","type":"text","conversion_output":true,"text":"different stakeholders, including participants, recruitment staff, study care team, internal","text_display":" different stakeholders, including participants, recruitment staff, study care team, internal","confidence":1,"confidence_rate":1},{"cnt":[[516,937],[1687,937],[1687,982],[516,982]],"region":{"top_left_x":515,"top_left_y":936,"width":1172,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"adb38580d2954c048b28c5138da2b901","type":"text","conversion_output":true,"text":"experts (study physician advisors), PCPs, and medical and administrative leaders at","text_display":" experts (study physician advisors), PCPs, and medical and administrative leaders at","confidence":1,"confidence_rate":1},{"cnt":[[516,986],[1515,986],[1515,1029],[516,1029]],"region":{"top_left_x":515,"top_left_y":986,"width":1000,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b28c4faaa60642a68a331b3733bf4b51","type":"text","conversion_output":true,"text":"participating clinics, at multiple time points throughout the trial period.","text_display":" participating clinics, at multiple time points throughout the trial period.","confidence":1,"confidence_rate":1},{"cnt":[[516,1070],[1755,1070],[1755,1111],[516,1111]],"region":{"top_left_x":515,"top_left_y":1069,"width":1241,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6233d19c05ea49328d23cc829b5d2cee","type":"text","conversion_output":true,"text":"In addition to qualitative evaluation through surveys and interviews, we will also collect","text_display":"\n\nIn addition to qualitative evaluation through surveys and interviews, we will also collect","confidence":1,"confidence_rate":1},{"cnt":[[518,1119],[1811,1119],[1811,1162],[518,1162]],"region":{"top_left_x":517,"top_left_y":1119,"width":1295,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4c8a791a8164ba7b1471e4f6c9afc5c","type":"text","conversion_output":true,"text":"data on the screening process, e.g., the proportion and representativeness of the patients who","text_display":" data on the screening process, e.g., the proportion and representativeness of the patients who","confidence":1,"confidence_rate":1},{"cnt":[[516,1164],[1807,1164],[1807,1210],[516,1210]],"region":{"top_left_x":515,"top_left_y":1164,"width":1292,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69baf5d009d94b55b684e233eed3e190","type":"text","conversion_output":true,"text":"are eligible at initial and subsequent screenings, reasons for exclusion, and demographics of","text_display":" are eligible at initial and subsequent screenings, reasons for exclusion, and demographics of","confidence":1,"confidence_rate":1},{"cnt":[[516,1216],[1764,1216],[1764,1257],[516,1257]],"region":{"top_left_x":515,"top_left_y":1216,"width":1249,"height":41},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11a08575ef904ad58a0a9d98c571186b","type":"text","conversion_output":true,"text":"patients who screen ineligible or decline participation. We also will assess the proportion","text_display":" patients who screen ineligible or decline participation. We also will assess the proportion","confidence":1,"confidence_rate":1},{"cnt":[[516,1263],[1815,1263],[1815,1308],[516,1308]],"region":{"top_left_x":515,"top_left_y":1263,"width":1301,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75cc0436678c4c7fb19f3f878674b363","type":"text","conversion_output":true,"text":"and representativeness of physicians willing to approve screening of their potentially eligible","text_display":" and representativeness of physicians willing to approve screening of their potentially eligible","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[516,1313],[1792,1313],[1792,1356],[516,1356]],"region":{"top_left_x":515,"top_left_y":1312,"width":1277,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20a37d6018e24beaa3e2854e2467a353","type":"text","conversion_output":true,"text":"patients, patient retention rates, and the representatives of patients who complete follow-up","text_display":" patients, patient retention rates, and the representatives of patients who complete follow-up","confidence":1,"confidence_rate":1},{"cnt":[[516,1362],[1038,1362],[1038,1403],[516,1403]],"region":{"top_left_x":515,"top_left_y":1362,"width":523,"height":41},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36413f5fd08f4487bb42beab4ed5b604","type":"text","conversion_output":true,"text":"assessments and reasons for dropout.","text_display":" assessments and reasons for dropout.","confidence":1,"confidence_rate":1},{"cnt":[[516,1444],[1796,1444],[1796,1487],[516,1487]],"region":{"top_left_x":515,"top_left_y":1443,"width":1282,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"703445dbf7d94d219181f196bf016e4a","type":"text","conversion_output":true,"text":"Intervention exposure and adherence measures will include attendance at one-on-one visits,","text_display":"\n\nIntervention exposure and adherence measures will include attendance at one-on-one visits,","confidence":1,"confidence_rate":1},{"cnt":[[516,1491],[1729,1491],[1729,1536],[516,1536]],"region":{"top_left_x":515,"top_left_y":1491,"width":1215,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64c05ff80c944232b4aea591bab0b906","type":"text","conversion_output":true,"text":"reasons for missed visits, frequency of self-monitoring records and secure emails, self-","text_display":" reasons for missed visits, frequency of self-monitoring records and secure emails, self","confidence":1,"confidence_rate":1},{"cnt":[[516,1543],[1781,1543],[1781,1583],[516,1583]],"region":{"top_left_x":515,"top_left_y":1542,"width":1267,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1b7f17cfeb34a71a5471109327de8e3","type":"text","conversion_output":true,"text":"reported completion of in-home videos, and number of completed counselling phone calls.","text_display":"reported completion of in-home videos, and number of completed counselling phone calls.","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[518,1590],[1721,1590],[1721,1635],[518,1635]],"region":{"top_left_x":517,"top_left_y":1589,"width":1204,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"587abeddcefa4a47a630622b99369e86","type":"text","conversion_output":true,"text":"Self-monitoring data obtained during intervention program will be used for adherence","text_display":" Self-monitoring data obtained during intervention program will be used for adherence","confidence":1,"confidence_rate":1},{"cnt":[[516,1637],[1691,1637],[1691,1682],[516,1682]],"region":{"top_left_x":515,"top_left_y":1637,"width":1176,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e60d70ec48e4671a25a006612826c89","type":"text","conversion_output":true,"text":"monitoring and for the coach to use in tailoring feedback for individual participants.","text_display":" monitoring and for the coach to use in tailoring feedback for individual participants.","confidence":1,"confidence_rate":1},{"cnt":[[305,1727],[724,1727],[724,1777],[305,1777]],"region":{"top_left_x":305,"top_left_y":1727,"width":420,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f00d45be51784d32a9fe9bd3f7126bcc","type":"section_header","conversion_output":false,"children_ids":["5fc29937191f40e598e6d6c5da302b4d"],"text":"","text_display":""},{"cnt":[[309,1732],[720,1732],[720,1772],[309,1772]],"region":{"top_left_x":309,"top_left_y":1731,"width":411,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fc29937191f40e598e6d6c5da302b4d","type":"text","conversion_output":true,"parent_id":"f00d45be51784d32a9fe9bd3f7126bcc","text":"2.10. Statistical Analysis","text_display":"\n\n\\subsection*{2.10. Statistical Analysis}","confidence":0.9990234375,"confidence_rate":0.9999684830886739},{"cnt":[[516,1792],[1671,1792],[1671,1835],[516,1835]],"region":{"top_left_x":515,"top_left_y":1791,"width":1157,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1385439d10994b4d846d2bd061146c07","type":"text","conversion_output":true,"text":"2.10.1. Analytic plan-Repeated-measures mixed-effects linear (for continuous","text_display":"\n2.10.1. Analytic plan-Repeated-measures mixed-effects linear (for continuous","confidence":0.9560546875,"confidence_rate":0.9994453370543845},{"cnt":[[516,1843],[1742,1843],[1742,1884],[516,1884]],"region":{"top_left_x":515,"top_left_y":1843,"width":1228,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf5e21b7db7d474786085ca9cf14e3a3","type":"text","conversion_output":true,"text":"outcomes) or logistic models (for categorical outcomes) using intention-to-treat tests of","text_display":" outcomes) or logistic models (for categorical outcomes) using intention-to-treat tests of","confidence":1,"confidence_rate":1},{"cnt":[[516,1891],[1732,1891],[1732,1931],[516,1931]],"region":{"top_left_x":515,"top_left_y":1890,"width":1217,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ca974b4c77647cdbbe05b5031e0cbb5","type":"text","conversion_output":true,"text":"group by time interactions will evaluate between-group differences in primary (Aim 1,","text_display":" group by time interactions will evaluate between-group differences in primary (Aim 1,","confidence":1,"confidence_rate":1},{"cnt":[[518,1938],[1807,1938],[1807,1983],[518,1983]],"region":{"top_left_x":517,"top_left_y":1937,"width":1290,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff3d96ad311e47b689ae311966b08d39","type":"text","conversion_output":true,"text":"Hypotheses 1 and 2) and secondary outcomes. The fixed effects of each model will include","text_display":" Hypotheses 1 and 2) and secondary outcomes. The fixed effects of each model will include","confidence":1,"confidence_rate":1},{"cnt":[[516,1989],[1781,1989],[1781,2030],[516,2030]],"region":{"top_left_x":515,"top_left_y":1989,"width":1267,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a31acce8ef2c437485cd48fa5efbadd6","type":"text","conversion_output":true,"text":"the baseline value of the outcome of interest, randomization balancing factors, group, time","text_display":" the baseline value of the outcome of interest, randomization balancing factors, group, time","confidence":1,"confidence_rate":1},{"cnt":[[516,2037],[1708,2037],[1708,2082],[516,2082]],"region":{"top_left_x":515,"top_left_y":2036,"width":1194,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95c415902d774b73b4f627b05598ddcb","type":"text","conversion_output":true,"text":"point, and group-by-time interaction indicators. The models will account for the non-","text_display":" point, and group-by-time interaction indicators. The models will account for the non","confidence":1,"confidence_rate":1},{"cnt":[[518,2086],[1760,2086],[1760,2129],[518,2129]],"region":{"top_left_x":517,"top_left_y":2086,"width":1243,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae96b40388be40b3a34acfe92ccb7148","type":"text","conversion_output":true,"text":"independence of repeated measures using a covariance structure within participants to be","text_display":"independence of repeated measures using a covariance structure within participants to be","confidence":0.99658203125,"confidence_rate":0.9999631853728411},{"cnt":[[516,2136],[1749,2136],[1749,2176],[516,2176]],"region":{"top_left_x":515,"top_left_y":2135,"width":1234,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62f6119b7b4b4524aab78dd2fdbb5538","type":"text","conversion_output":true,"text":"determined by the least Bayesian Information Criterion and clustering of patients within","text_display":" determined by the least Bayesian Information Criterion and clustering of patients within","confidence":1,"confidence_rate":1},{"cnt":[[516,2183],[1807,2183],[1807,2224],[516,2224]],"region":{"top_left_x":515,"top_left_y":2182,"width":1292,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6325822051a54f8c97c676547b5e14e6","type":"text","conversion_output":true,"text":"primary care providers. Maximum likelihood estimation in mixed modeling will be used for","text_display":" primary care providers. Maximum likelihood estimation in mixed modeling will be used for","confidence":1,"confidence_rate":1},{"cnt":[[516,2230],[1794,2230],[1794,2275],[516,2275]],"region":{"top_left_x":515,"top_left_y":2230,"width":1279,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10b7cb239b124c24bc4759142f58c0d6","type":"text","conversion_output":true,"text":"missing data. We will document the extent and pattern of missing data and the reasons, and","text_display":" missing data. We will document the extent and pattern of missing data and the reasons, and","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[516,2282],[1663,2282],[1663,2322],[516,2322]],"region":{"top_left_x":515,"top_left_y":2281,"width":1148,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed36e90c40a644b994a90d43a79d8152","type":"text","conversion_output":true,"text":"will conduct sensitivity analyses of the impact of missing data (e.g., with multiple","text_display":" will conduct sensitivity analyses of the impact of missing data (e.g., with multiple","confidence":1,"confidence_rate":1},{"cnt":[[516,2325],[1811,2325],[1811,2374],[516,2374]],"region":{"top_left_x":515,"top_left_y":2324,"width":1297,"height":51},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a33207a13384846bfc28e089b418bf2","type":"text","conversion_output":true,"text":"imputation, \\({ }^{59-61}\\) on stability of the primary results). Models will be adjusted for nonlinearity","text_display":" imputation, \\({ }^{59-61}\\) on stability of the primary results). Models will be adjusted for nonlinearity","confidence":1,"confidence_rate":1},{"cnt":[[559,2479],[1381,2479],[1381,2516],[559,2516]],"region":{"top_left_x":558,"top_left_y":2479,"width":824,"height":37},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3a0712a14eae477398b898a9c2821089","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-12","page":12,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"65e6feb6112d44d8b0506c008c8d9f94","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,133],[1815,133],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":133,"width":98,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6aa54025eaac49b197533fcc98798acf","type":"page_info","conversion_output":false,"text":"Page 12","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[511,202],[1790,202],[1790,260],[511,260]],"region":{"top_left_x":511,"top_left_y":201,"width":1279,"height":59},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba0768d6fa774530bc94198dd130fd52","type":"text","conversion_output":true,"text":"and/or unequal variances based on residuals from a model using residual plots. Polynomial","text_display":"\nand/or unequal variances based on residuals from a model using residual plots. Polynomial","confidence":1,"confidence_rate":1},{"cnt":[[54,249],[118,249],[118,2376],[54,2376]],"region":{"top_left_x":53,"top_left_y":249,"width":66,"height":2128},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f217645c1151448296eb44cbe13e987e","type":"rotated_container","conversion_output":false,"children_ids":["ad740db4d4e14f62bac5a0f3e7c861a8"],"text":"","text_display":""},{"cnt":[[59,254],[114,254],[114,2372],[59,2372]],"region":{"top_left_x":58,"top_left_y":254,"width":56,"height":2118},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad740db4d4e14f62bac5a0f3e7c861a8","type":"table","conversion_output":true,"parent_id":"f217645c1151448296eb44cbe13e987e","text":"Author Manuscript Author Manuscript Author Manuscript Author Manuscript","text_display":"\n\nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript","confidence":0.9970729344058782,"confidence_rate":0.9999614302460895},{"cnt":[[516,262],[1742,262],[1742,307],[516,307]],"region":{"top_left_x":515,"top_left_y":262,"width":1228,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"378318bffe584c0689de2e1dd5c7fe73","type":"text","conversion_output":true,"text":"terms may be included if indicated. Appropriate transformation of the outcome variable","text_display":"\nterms may be included if indicated. Appropriate transformation of the outcome variable","confidence":1,"confidence_rate":1},{"cnt":[[516,309],[1760,309],[1760,354],[516,354]],"region":{"top_left_x":515,"top_left_y":309,"width":1245,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b38d3660c6874745b4975178e81e3fea","type":"text","conversion_output":true,"text":"(e.g., logarithmic) will be considered as a remedy for unequal variances. Also, the model","text_display":" (e.g., logarithmic) will be considered as a remedy for unequal variances. Also, the model","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[516,357],[1779,357],[1779,402],[516,402]],"region":{"top_left_x":515,"top_left_y":356,"width":1264,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d1fe5b0023847d5b213b690d41e50f4","type":"text","conversion_output":true,"text":"could be altered to a heterogeneous variance model if participants in different intervention","text_display":" could be altered to a heterogeneous variance model if participants in different intervention","confidence":1,"confidence_rate":1},{"cnt":[[516,408],[1772,408],[1772,453],[516,453]],"region":{"top_left_x":515,"top_left_y":408,"width":1258,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"063fe5f25f5343eba86f62418bfb737b","type":"text","conversion_output":true,"text":"arms are found to have different variances. We will verify that mixed model-based results","text_display":" arms are found to have different variances. We will verify that mixed model-based results","confidence":1,"confidence_rate":1},{"cnt":[[516,455],[1689,455],[1689,501],[516,501]],"region":{"top_left_x":515,"top_left_y":455,"width":1174,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ca56b4073474877ad876f7b59c42e3f","type":"text","conversion_output":true,"text":"are not sensitive to violations of model assumptions with permutation and bootstrap","text_display":" are not sensitive to violations of model assumptions with permutation and bootstrap","confidence":1,"confidence_rate":1},{"cnt":[[516,498],[819,498],[819,548],[516,548]],"region":{"top_left_x":515,"top_left_y":498,"width":304,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a467e8938d114e71a3c399cca57cd1b4","type":"text","conversion_output":true,"text":"resampling tests. \\({ }^{62,63}\\)","text_display":" resampling tests. \\({ }^{62,63}\\)","confidence":0.99951171875,"confidence_rate":0.9999856353826395},{"cnt":[[516,589],[1721,589],[1721,634],[516,634]],"region":{"top_left_x":515,"top_left_y":588,"width":1206,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5be45560a8044f2a9dad84cad189d44","type":"text","conversion_output":true,"text":"Mediation analyses will explore changes in potential putative mediators (e.g. problem","text_display":"\n\nMediation analyses will explore changes in potential putative mediators (e.g. problem","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[516,636],[1772,636],[1772,683],[516,683]],"region":{"top_left_x":515,"top_left_y":635,"width":1258,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44816dfe68f94e7f87b834886792d857","type":"text","conversion_output":true,"text":"solving, antidepressant medication change, physical activity, dietary intake, sleep quality)","text_display":" solving, antidepressant medication change, physical activity, dietary intake, sleep quality)","confidence":1,"confidence_rate":1},{"cnt":[[516,683],[1745,683],[1745,728],[516,728]],"region":{"top_left_x":515,"top_left_y":683,"width":1230,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2304c52c9b2a4633abb17afa2f75cef5","type":"text","conversion_output":true,"text":"and their effects on treatment response. Using MacKinnon's product of coefficients test","text_display":" and their effects on treatment response. Using MacKinnon's product of coefficients test","confidence":0.99853515625,"confidence_rate":0.9999840662390905},{"cnt":[[516,728],[1644,728],[1644,780],[516,780]],"region":{"top_left_x":515,"top_left_y":728,"width":1129,"height":52},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0654499aafb447ccad92d1a8b36f2037","type":"text","conversion_output":true,"text":"\\((\\alpha \\beta)^{64}\\) we will examine longitudinal and contemporaneous mediation separately.","text_display":" \\((\\alpha \\beta)^{64}\\) we will examine longitudinal and contemporaneous mediation separately.","confidence":1,"confidence_rate":1},{"cnt":[[516,782],[1781,782],[1781,827],[516,827]],"region":{"top_left_x":515,"top_left_y":782,"width":1267,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28a519ebf1e34a2e94e838478e517d51","type":"text","conversion_output":true,"text":"Longitudinal mediation refers to changes in mediators from baseline to 6 months followed","text_display":" Longitudinal mediation refers to changes in mediators from baseline to 6 months followed","confidence":1,"confidence_rate":1},{"cnt":[[516,829],[1691,829],[1691,879],[516,879]],"region":{"top_left_x":515,"top_left_y":829,"width":1176,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e64fb1ced244e49aca468a23f02b81e","type":"text","conversion_output":true,"text":"by change in BMI and/or SCL-20. Contemporaneous mediation refers to changes in","text_display":" by change in BMI and/or SCL-20. Contemporaneous mediation refers to changes in","confidence":1,"confidence_rate":1},{"cnt":[[516,879],[1732,879],[1732,926],[516,926]],"region":{"top_left_x":515,"top_left_y":878,"width":1217,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07d7657e49684599ad5f3fa0f7458456","type":"text","conversion_output":true,"text":"mediators and change in BMI and/or SCL-20 from baseline to 12 months. Asymmetric","text_display":" mediators and change in BMI and/or SCL-20 from baseline to 12 months. Asymmetric","confidence":1,"confidence_rate":1},{"cnt":[[516,928],[1717,928],[1717,973],[516,973]],"region":{"top_left_x":515,"top_left_y":928,"width":1202,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27855f3bd5d74701b2adb4bfd9ad9f86","type":"text","conversion_output":true,"text":"confidence limits will be constructed based on the distribution of the product with the","text_display":" confidence limits will be constructed based on the distribution of the product with the","confidence":1,"confidence_rate":1},{"cnt":[[516,975],[1734,975],[1734,1021],[516,1021]],"region":{"top_left_x":515,"top_left_y":975,"width":1219,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7501e17062ce4f1aaa65ecb212579e07","type":"text","conversion_output":true,"text":"PRODCLIN program. Because multicollinearity may be present in a multiple mediator","text_display":" PRODCLIN program. Because multicollinearity may be present in a multiple mediator","confidence":0.9990234375,"confidence_rate":0.9999886391383975},{"cnt":[[516,1025],[1682,1025],[1682,1070],[516,1070]],"region":{"top_left_x":515,"top_left_y":1024,"width":1168,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc51d5cfa9134c05b4f96a2a77559422","type":"text","conversion_output":true,"text":"model, we first will test each mediator separately in a single-mediator model. Next,","text_display":" model, we first will test each mediator separately in a single-mediator model. Next,","confidence":1,"confidence_rate":1},{"cnt":[[516,1074],[1798,1074],[1798,1119],[516,1119]],"region":{"top_left_x":515,"top_left_y":1074,"width":1284,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab96a19174b948078590bb7d9b000b05","type":"text","conversion_output":true,"text":"multiple-mediator models will be used to test for independent and suppression effects when","text_display":" multiple-mediator models will be used to test for independent and suppression effects when","confidence":1,"confidence_rate":1},{"cnt":[[516,1121],[1755,1121],[1755,1167],[516,1167]],"region":{"top_left_x":515,"top_left_y":1121,"width":1241,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"476652412e154b0492c49c45a7760769","type":"text","conversion_output":true,"text":"all variables found to be at least marginally significant in the single-mediator models are","text_display":" all variables found to be at least marginally significant in the single-mediator models are","confidence":1,"confidence_rate":1},{"cnt":[[516,1171],[1783,1171],[1783,1216],[516,1216]],"region":{"top_left_x":515,"top_left_y":1170,"width":1269,"height":47},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce0e1246d489423283890e7994b5efe6","type":"text","conversion_output":true,"text":"entered simultaneously. To determine the extent of mediated effect, the percentage of total","text_display":" entered simultaneously. To determine the extent of mediated effect, the percentage of total","confidence":1,"confidence_rate":1},{"cnt":[[516,1220],[1766,1220],[1766,1265],[516,1265]],"region":{"top_left_x":515,"top_left_y":1220,"width":1252,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee844f2701f2478fb57019f324b156fa","type":"text","conversion_output":true,"text":"effect mediated will be calculated for each significant mediator as \\(\\alpha \\beta /(\\alpha \\beta+\\gamma)\\), where \\(\\gamma\\) is","text_display":" effect mediated will be calculated for each significant mediator as \\(\\alpha \\beta /(\\alpha \\beta+\\gamma)\\), where \\(\\gamma\\) is","confidence":0.9985356330871582,"confidence_rate":0.9999854907968839},{"cnt":[[516,1268],[1098,1268],[1098,1311],[516,1311]],"region":{"top_left_x":515,"top_left_y":1267,"width":583,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cbc20fca34743388517e362bac7deb6","type":"text","conversion_output":true,"text":"the direct intervention effect on outcome.","text_display":" the direct intervention effect on outcome.","confidence":1,"confidence_rate":1},{"cnt":[[516,1351],[1777,1351],[1777,1396],[516,1396]],"region":{"top_left_x":515,"top_left_y":1351,"width":1262,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c03dfd778cc04d70bfd03855a84f7706","type":"text","conversion_output":true,"text":"Moderation analyses will explore differences in intervention effect by potential subgroups","text_display":"\n\nModeration analyses will explore differences in intervention effect by potential subgroups","confidence":1,"confidence_rate":1},{"cnt":[[516,1401],[1815,1401],[1815,1446],[516,1446]],"region":{"top_left_x":515,"top_left_y":1400,"width":1301,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78d254117c1d4f18ba3fccecb3cc5a4c","type":"text","conversion_output":true,"text":"(e.g., according to gender, age, race/ethnicity, and education). These analyses will follow the","text_display":" (e.g., according to gender, age, race/ethnicity, and education). These analyses will follow the","confidence":1,"confidence_rate":1},{"cnt":[[516,1448],[1760,1448],[1760,1493],[516,1493]],"region":{"top_left_x":515,"top_left_y":1448,"width":1245,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59c3809780e44d47a4db0438a375d4f6","type":"text","conversion_output":true,"text":"same general analytic approach as described above for primary and secondary outcomes,","text_display":" same general analytic approach as described above for primary and secondary outcomes,","confidence":1,"confidence_rate":1},{"cnt":[[516,1497],[1815,1497],[1815,1543],[516,1543]],"region":{"top_left_x":515,"top_left_y":1497,"width":1301,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07dc00f99fb749c59cc48b304e83c04f","type":"text","conversion_output":true,"text":"with the inclusion of appropriate moderator main effects and moderator-by-group interaction","text_display":" with the inclusion of appropriate moderator main effects and moderator-by-group interaction","confidence":1,"confidence_rate":1},{"cnt":[[516,1551],[608,1551],[608,1586],[516,1586]],"region":{"top_left_x":515,"top_left_y":1551,"width":94,"height":35},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8a5e9c659c747b0abc97f7b48df1d9e","type":"text","conversion_output":true,"text":"terms.","text_display":" terms.","confidence":1,"confidence_rate":1},{"cnt":[[516,1629],[1815,1629],[1815,1674],[516,1674]],"region":{"top_left_x":515,"top_left_y":1628,"width":1301,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84cbc505e27f48b0a7bd6641f7bcd174","type":"text","conversion_output":true,"text":"Cost-effectiveness analyses (Aim 1, Hypothesis 3) will extend and combine existing models","text_display":"\n\nCost-effectiveness analyses (Aim 1, Hypothesis 3) will extend and combine existing models","confidence":1,"confidence_rate":1},{"cnt":[[516,1723],[516,1670],[1704,1672],[1704,1725]],"region":{"top_left_x":515,"top_left_y":1669,"width":1189,"height":57},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0ff8d25a7884781a9238628791992a7","type":"text","conversion_output":true,"text":"for obesity and depression that we and others have developed. \\({ }^{65-70}\\) We will compare","text_display":" for obesity and depression that we and others have developed. \\({ }^{65-70}\\) We will compare","confidence":1,"confidence_rate":1},{"cnt":[[516,1727],[1772,1727],[1772,1772],[516,1772]],"region":{"top_left_x":515,"top_left_y":1727,"width":1258,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8896b3c852f4e818a624de0e1f39de9","type":"text","conversion_output":true,"text":"incremental costs, estimated from the perspectives of health systems (direct medical costs","text_display":" incremental costs, estimated from the perspectives of health systems (direct medical costs","confidence":1,"confidence_rate":1},{"cnt":[[516,1775],[1803,1775],[1803,1820],[516,1820]],"region":{"top_left_x":515,"top_left_y":1774,"width":1288,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3dd2d66e408449f8864c27639b048547","type":"text","conversion_output":true,"text":"only) and society (direct medical and non-medical costs), to incremental benefits, expressed","text_display":" only) and society (direct medical and non-medical costs), to incremental benefits, expressed","confidence":1,"confidence_rate":1},{"cnt":[[516,1826],[1803,1826],[1803,1869],[516,1869]],"region":{"top_left_x":515,"top_left_y":1826,"width":1288,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fd724eadc87493a99b7ad946a6a700e","type":"text","conversion_output":true,"text":"as quality-adjusted life years gained. We will also consider the number needed to treat as an","text_display":" as quality-adjusted life years gained. We will also consider the number needed to treat as an","confidence":1,"confidence_rate":1},{"cnt":[[516,1873],[1755,1873],[1755,1919],[516,1919]],"region":{"top_left_x":515,"top_left_y":1873,"width":1241,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9b34cd6bb4d447fb203cf999dac3e47","type":"text","conversion_output":true,"text":"important and clinically-relevant outcome and estimate the intervention cost per number","text_display":" important and clinically-relevant outcome and estimate the intervention cost per number","confidence":1,"confidence_rate":1},{"cnt":[[516,1921],[1704,1921],[1704,1966],[516,1966]],"region":{"top_left_x":515,"top_left_y":1920,"width":1189,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"632ecdd8ce954829a77f1feec9c88a21","type":"text","conversion_output":true,"text":"needed to treat. The use of quality-adjusted life years allows for comparisons of both","text_display":" needed to treat. The use of quality-adjusted life years allows for comparisons of both","confidence":1,"confidence_rate":1},{"cnt":[[516,1972],[1764,1972],[1764,2015],[516,2015]],"region":{"top_left_x":515,"top_left_y":1972,"width":1249,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d54fcac2b24a47efbf6f59a91a6ec3ad","type":"text","conversion_output":true,"text":"changes in morbidity and health status as well as mortality effects based on change in the","text_display":" changes in morbidity and health status as well as mortality effects based on change in the","confidence":1,"confidence_rate":1},{"cnt":[[516,2020],[1798,2020],[1798,2065],[516,2065]],"region":{"top_left_x":515,"top_left_y":2019,"width":1284,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18615ab9415b4d85be87b580c3a9d0d5","type":"text","conversion_output":true,"text":"risk of death and, among survivors, reduction in quality of life due to nonfatal events, given","text_display":" risk of death and, among survivors, reduction in quality of life due to nonfatal events, given","confidence":1,"confidence_rate":1},{"cnt":[[516,2062],[1704,2062],[1704,2112],[516,2112]],"region":{"top_left_x":515,"top_left_y":2062,"width":1189,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dbdf31ee21e40a0ac5e76ceb33a50ff","type":"text","conversion_output":true,"text":"the probabilities of disease progression in the target population. \\({ }^{68,71}\\) We will convert","text_display":" the probabilities of disease progression in the target population. \\({ }^{68,71}\\) We will convert","confidence":0.9970703125,"confidence_rate":0.9999715150908018},{"cnt":[[516,2116],[1775,2116],[1775,2159],[516,2159]],"region":{"top_left_x":515,"top_left_y":2116,"width":1260,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e525f7d387345ef8f675f5ed71c8315","type":"text","conversion_output":true,"text":"Cohen's \\(d\\) effect sizes to estimates of the number needed to treat to have one more patient","text_display":" Cohen's \\(d\\) effect sizes to estimates of the number needed to treat to have one more patient","confidence":1,"confidence_rate":1},{"cnt":[[516,2161],[1732,2161],[1732,2206],[516,2206]],"region":{"top_left_x":515,"top_left_y":2161,"width":1217,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b305fc4bb07b4475aa7ba6556476b474","type":"text","conversion_output":true,"text":"with better outcomes in the intervention arm vs. usual care. \\({ }^{72}\\) We will exclude from all","text_display":" with better outcomes in the intervention arm vs. usual care. \\({ }^{72}\\) We will exclude from all","confidence":1,"confidence_rate":1},{"cnt":[[516,2213],[1704,2213],[1704,2258],[516,2258]],"region":{"top_left_x":515,"top_left_y":2212,"width":1189,"height":47},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fd189d8aab044258ca7bbfc84ca87cb","type":"text","conversion_output":true,"text":"analyses research-related costs, such as costs of recruitment, screening, and outcome","text_display":" analyses research-related costs, such as costs of recruitment, screening, and outcome","confidence":1,"confidence_rate":1},{"cnt":[[516,2262],[1777,2262],[1777,2305],[516,2305]],"region":{"top_left_x":515,"top_left_y":2262,"width":1262,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72d16dfc6325474abfe977d0dbbe50fa","type":"text","conversion_output":true,"text":"surveillance that are beyond those recommended for routine clinical practice. Intervention","text_display":" surveillance that are beyond those recommended for routine clinical practice. Intervention","confidence":1,"confidence_rate":1},{"cnt":[[516,2312],[1710,2312],[1710,2357],[516,2357]],"region":{"top_left_x":515,"top_left_y":2311,"width":1196,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa1a9ee7ca994ac4af31c40483a41256","type":"text","conversion_output":true,"text":"start-up costs, fixed costs of sustaining the intervention, and marginal costs of adding","text_display":" start-up costs, fixed costs of sustaining the intervention, and marginal costs of adding","confidence":1,"confidence_rate":1},{"cnt":[[516,2359],[1807,2359],[1807,2408],[516,2408]],"region":{"top_left_x":515,"top_left_y":2358,"width":1292,"height":51},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a69f4a3f29449ff82f8460f9be44dd3","type":"text","conversion_output":true,"text":"additional participants to the intervention will be differentiated because they are relevant for","text_display":" additional participants to the intervention will be differentiated because they are relevant for","confidence":1,"confidence_rate":1},{"cnt":[[556,2479],[1381,2479],[1381,2516],[556,2516]],"region":{"top_left_x":556,"top_left_y":2479,"width":826,"height":37},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"830cc44b679a4bfa827998245ec35228","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.994140625,"confidence_rate":0.9999236833214998}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-13","page":13,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fee39970de0243e1ae497e6c9d568514","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,133],[1815,133],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":133,"width":98,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f58290988b944e08b64e2dbe183922cb","type":"page_info","conversion_output":false,"text":"Page 13","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[511,202],[1783,202],[1783,260],[511,260]],"region":{"top_left_x":511,"top_left_y":201,"width":1273,"height":59},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7c8d746f9364e19aa532882c0b53aca","type":"text","conversion_output":true,"text":"different decisions: whether to implement the intervention in the first place and whether to","text_display":"\ndifferent decisions: whether to implement the intervention in the first place and whether to","confidence":1,"confidence_rate":1},{"cnt":[[54,247],[118,247],[118,2378],[54,2378]],"region":{"top_left_x":53,"top_left_y":247,"width":66,"height":2132},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6abd61eb7fa948fa824ce6442bc266fb","type":"rotated_container","conversion_output":false,"children_ids":["393b6f263a8445d2856cc5d60591b127"],"text":"","text_display":""},{"cnt":[[59,252],[114,252],[114,2372],[59,2372]],"region":{"top_left_x":58,"top_left_y":252,"width":56,"height":2121},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"393b6f263a8445d2856cc5d60591b127","type":"table","conversion_output":true,"parent_id":"6abd61eb7fa948fa824ce6442bc266fb","text":"Author Manuscript Author Manuscript Author Manuscript Author Manuscript","text_display":"\n\nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript","confidence":0.9970729344058782,"confidence_rate":0.9999614302460895},{"cnt":[[516,262],[1781,262],[1781,305],[516,305]],"region":{"top_left_x":515,"top_left_y":262,"width":1267,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c98656d16cb4b65a25131c63f595b5f","type":"text","conversion_output":true,"text":"sustain or expand it over time. We will use simulation models, similar to those in Diabetes","text_display":"\nsustain or expand it over time. We will use simulation models, similar to those in Diabetes","confidence":1,"confidence_rate":1},{"cnt":[[516,305],[1807,305],[1807,354],[516,354]],"region":{"top_left_x":515,"top_left_y":305,"width":1292,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0eb3a02aab7e427f80607613b137b47e","type":"text","conversion_output":true,"text":"Prevention Program and Sequenced Treatment Alternatives to Relieve Depression, \\(68,73,74\\) to","text_display":" Prevention Program and Sequenced Treatment Alternatives to Relieve Depression, \\(68,73,74\\) to","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[516,357],[1794,357],[1794,404],[516,404]],"region":{"top_left_x":515,"top_left_y":356,"width":1279,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"079188ccfdc84eb0bb5043489eceaf8c","type":"text","conversion_output":true,"text":"analyze incremental cost-effectiveness ratios during the trial and projected into 5-, 10-, 20-,","text_display":" analyze incremental cost-effectiveness ratios during the trial and projected into 5-, 10-, 20-,","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[516,408],[1760,408],[1760,451],[516,451]],"region":{"top_left_x":515,"top_left_y":408,"width":1245,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3f859cfbec54948b867d1105444a1b8","type":"text","conversion_output":true,"text":"30-year, and lifetime horizons. Cost-utility estimates with different time horizons will be","text_display":" 30-year, and lifetime horizons. Cost-utility estimates with different time horizons will be","confidence":0.75341796875,"confidence_rate":0.9970550206739275},{"cnt":[[516,455],[1762,455],[1762,501],[516,501]],"region":{"top_left_x":515,"top_left_y":455,"width":1247,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd4d5a7d7c644f019a4b9bb67ee3e220","type":"text","conversion_output":true,"text":"useful for stakeholders deciding on program implementation. Sensitivity analyses will be","text_display":" useful for stakeholders deciding on program implementation. Sensitivity analyses will be","confidence":1,"confidence_rate":1},{"cnt":[[516,498],[1629,498],[1629,552],[516,552]],"region":{"top_left_x":515,"top_left_y":498,"width":1114,"height":55},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbdc932b14224feca89ce0eb2e74f56b","type":"text","conversion_output":true,"text":"performed and results will be interpreted according to standard guidelines. \\({ }^{75-77}\\)","text_display":" performed and results will be interpreted according to standard guidelines. \\({ }^{75-77}\\)","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[516,580],[1790,580],[1790,634],[516,634]],"region":{"top_left_x":515,"top_left_y":580,"width":1275,"height":54},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12a58fccc8324589ad208074f57fac87","type":"text","conversion_output":true,"text":"We will analyze quantitative process data using standard tests, e.g., Student's \\(t\\)-tests and \\(\\chi^{2}\\)","text_display":"\n\nWe will analyze quantitative process data using standard tests, e.g., Student's \\(t\\)-tests and \\(\\chi^{2}\\)","confidence":1,"confidence_rate":1},{"cnt":[[516,636],[1781,636],[1781,681],[516,681]],"region":{"top_left_x":515,"top_left_y":635,"width":1267,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa595126ddec4acba065424eeeb544c5","type":"text","conversion_output":true,"text":"tests for continuous and categorical variables, respectively (Aim 2). We will use NVivo to","text_display":" tests for continuous and categorical variables, respectively (Aim 2). We will use NVivo to","confidence":1,"confidence_rate":1},{"cnt":[[516,681],[1693,681],[1693,733],[516,733]],"region":{"top_left_x":515,"top_left_y":681,"width":1178,"height":52},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80770afdba724f599a81aec1309e4e9a","type":"text","conversion_output":true,"text":"analyze all qualitative data. \\({ }^{78}\\) Two independent and trained researchers will code all","text_display":" analyze all qualitative data. \\({ }^{78}\\) Two independent and trained researchers will code all","confidence":1,"confidence_rate":1},{"cnt":[[516,735],[1781,735],[1781,780],[516,780]],"region":{"top_left_x":515,"top_left_y":734,"width":1267,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e22227837194b3ba63a9ccca34433de","type":"text","conversion_output":true,"text":"qualitative data separately by stakeholder group (e.g., participants, recruitment staff, study","text_display":" qualitative data separately by stakeholder group (e.g., participants, recruitment staff, study","confidence":1,"confidence_rate":1},{"cnt":[[516,782],[1783,782],[1783,827],[516,827]],"region":{"top_left_x":515,"top_left_y":782,"width":1269,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e97d87aa04ae4be0bc974c16b7305de3","type":"text","conversion_output":true,"text":"care team, internal experts, PCPs, and medical and administrative leaders) using principles","text_display":" care team, internal experts, PCPs, and medical and administrative leaders) using principles","confidence":1,"confidence_rate":1},{"cnt":[[516,827],[1747,827],[1747,879],[516,879]],"region":{"top_left_x":515,"top_left_y":827,"width":1232,"height":52},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4a47a36c0c547d989fee5036d7f3d06","type":"text","conversion_output":true,"text":"of content analysis. \\({ }^{79}\\) Codes will be developed based on the RE-AIM domains assessed.","text_display":" of content analysis. \\({ }^{79}\\) Codes will be developed based on the RE-AIM domains assessed.","confidence":1,"confidence_rate":1},{"cnt":[[516,879],[1781,879],[1781,926],[516,926]],"region":{"top_left_x":515,"top_left_y":878,"width":1267,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3603b96e141840bbb469ca4f2c41457d","type":"text","conversion_output":true,"text":"Quantitative process data and qualitative data will be combined to draw conclusions about","text_display":" Quantitative process data and qualitative data will be combined to draw conclusions about","confidence":1,"confidence_rate":1},{"cnt":[[516,924],[1528,924],[1528,973],[516,973]],"region":{"top_left_x":515,"top_left_y":923,"width":1013,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a039e8b450f14ead9fd8e005962b076f","type":"text","conversion_output":true,"text":"reach, adoption, implementation, and maintenance of the intervention. \\({ }^{80}\\)","text_display":" reach, adoption, implementation, and maintenance of the intervention. \\({ }^{80}\\)","confidence":1,"confidence_rate":1},{"cnt":[[516,1018],[1798,1018],[1798,1068],[516,1068]],"region":{"top_left_x":515,"top_left_y":1018,"width":1284,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f00c1a1c150542f78176a93ffaa950de","type":"text","conversion_output":true,"text":"2.10.2. Sample size and data interpretation-The trial with 202 participants per arm","text_display":"\n2.10.2. Sample size and data interpretation-The trial with 202 participants per arm","confidence":0.9442639350891113,"confidence_rate":0.9993699836024085},{"cnt":[[516,1068],[1794,1068],[1794,1115],[516,1115]],"region":{"top_left_x":515,"top_left_y":1067,"width":1279,"height":49},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa825e6f87db43a9b64e1b2e48f82c95","type":"text","conversion_output":true,"text":"has \\(90 \\%\\) power to detect a standardized mean difference of 0.35 (Cohen's \\(d\\) ) in the primary","text_display":" has \\(90 \\%\\) power to detect a standardized mean difference of 0.35 (Cohen's \\(d\\) ) in the primary","confidence":0.9960973262786865,"confidence_rate":0.9999624015816049},{"cnt":[[516,1117],[1794,1117],[1794,1162],[516,1162]],"region":{"top_left_x":515,"top_left_y":1117,"width":1279,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c65200573de47b6bb0a6420dd0b9ab0","type":"text","conversion_output":true,"text":"endpoints of BMI and SCL-20 scores at 12 months between the intervention and usual care","text_display":" endpoints of BMI and SCL-20 scores at 12 months between the intervention and usual care","confidence":1,"confidence_rate":1},{"cnt":[[516,1164],[1790,1164],[1790,1210],[516,1210]],"region":{"top_left_x":515,"top_left_y":1164,"width":1275,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5e92bda79cc4ae8881d2406dcd8e392","type":"text","conversion_output":true,"text":"group at \\(\\alpha=5 \\%\\) (2-sided), assuming at least \\(85 \\%\\) retention at 12 months based on prior trial","text_display":" group at \\(\\alpha=5 \\%\\) (2-sided), assuming at least \\(85 \\%\\) retention at 12 months based on prior trial","confidence":0.7432503890013322,"confidence_rate":0.9971509672407349},{"cnt":[[516,1210],[1760,1210],[1760,1261],[516,1261]],"region":{"top_left_x":515,"top_left_y":1209,"width":1245,"height":53},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cd827cc43f44c60a7b58aef29208592","type":"text","conversion_output":true,"text":"experiences. \\(32,33,38,81,82\\) We used a \\(t\\)-test with simplified assumptions to estimate power,","text_display":" experiences. \\(32,33,38,81,82\\) We used a \\(t\\)-test with simplified assumptions to estimate power,","confidence":0.51513671875,"confidence_rate":0.9935806639937173},{"cnt":[[516,1263],[1727,1263],[1727,1308],[516,1308]],"region":{"top_left_x":515,"top_left_y":1263,"width":1213,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"325e3f699ca5411eae6973f27dddb146","type":"text","conversion_output":true,"text":"whereas actual power likely will be greater due to increased efficiency associated with","text_display":" whereas actual power likely will be greater due to increased efficiency associated with","confidence":1,"confidence_rate":1},{"cnt":[[516,1308],[1712,1308],[1712,1360],[516,1360]],"region":{"top_left_x":515,"top_left_y":1308,"width":1198,"height":52},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9147bdfe972949e4942ad4a42eaf03d4","type":"text","conversion_output":true,"text":"repeated-measures mixed models with baseline and covariate adjustments. \\({ }^{83}\\) Because","text_display":" repeated-measures mixed models with baseline and covariate adjustments. \\({ }^{83}\\) Because","confidence":1,"confidence_rate":1},{"cnt":[[516,1360],[1695,1360],[1695,1407],[516,1407]],"region":{"top_left_x":515,"top_left_y":1359,"width":1181,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af40b2ece0304d7f8117f9f61b8be917","type":"text","conversion_output":true,"text":"treatment success will be judged on both (not either) primary outcomes, multiplicity","text_display":" treatment success will be judged on both (not either) primary outcomes, multiplicity","confidence":1,"confidence_rate":1},{"cnt":[[516,1405],[1695,1405],[1695,1454],[516,1454]],"region":{"top_left_x":515,"top_left_y":1405,"width":1181,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07f8c588ac0a4ee5b4c088ea671d3d7a","type":"text","conversion_output":true,"text":"adjustment is unnecessary. \\({ }^{84}\\) No multiplicity adjustment will be made for secondary","text_display":" adjustment is unnecessary. \\({ }^{84}\\) No multiplicity adjustment will be made for secondary","confidence":1,"confidence_rate":1},{"cnt":[[516,1457],[1723,1457],[1723,1502],[516,1502]],"region":{"top_left_x":515,"top_left_y":1456,"width":1209,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"668340941e094a0f9d0271dd8a22b7e4","type":"text","conversion_output":true,"text":"analyses, which are intended to complement the primary findings and to inform future","text_display":" analyses, which are intended to complement the primary findings and to inform future","confidence":1,"confidence_rate":1},{"cnt":[[516,1504],[1772,1504],[1772,1553],[516,1553]],"region":{"top_left_x":515,"top_left_y":1503,"width":1258,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"892ab96f8f99403684efb074fc50abbb","type":"text","conversion_output":true,"text":"research. They will be interpreted within that context, considering the totality of evidence","text_display":" research. They will be interpreted within that context, considering the totality of evidence","confidence":1,"confidence_rate":1},{"cnt":[[516,1549],[724,1549],[724,1596],[516,1596]],"region":{"top_left_x":515,"top_left_y":1549,"width":210,"height":48},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73e1154eb16a4ea2b68ae65ecd261da8","type":"text","conversion_output":true,"text":"available. \\({ }^{84,85}\\)","text_display":" available. \\({ }^{84,85}\\)","confidence":0.99853515625,"confidence_rate":0.9999457082263518},{"cnt":[[516,1637],[1751,1637],[1751,1687],[516,1687]],"region":{"top_left_x":515,"top_left_y":1637,"width":1236,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b93dc0fa670c47449b7f4393db94144d","type":"text","conversion_output":true,"text":"We chose a \\(d\\) of 0.35 as the minimum important between-group difference based on our","text_display":"\n\nWe chose a \\(d\\) of 0.35 as the minimum important between-group difference based on our","confidence":0.97705078125,"confidence_rate":0.9997530448433857},{"cnt":[[516,1689],[1755,1689],[1755,1734],[516,1734]],"region":{"top_left_x":515,"top_left_y":1688,"width":1241,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c5b2818a7ea49e88a8d20f5dbb2321b","type":"text","conversion_output":true,"text":"prior studies and other available literature. Previously, we observed a standardized mean","text_display":" prior studies and other available literature. Previously, we observed a standardized mean","confidence":1,"confidence_rate":1},{"cnt":[[516,1732],[1790,1732],[1790,1781],[516,1781]],"region":{"top_left_x":515,"top_left_y":1731,"width":1275,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"280ef9a7c35542d5887c3be03dbbe05b","type":"text","conversion_output":true,"text":"difference of 0.46 between usual care and the GLB weight loss intervention being tested in","text_display":" difference of 0.46 between usual care and the GLB weight loss intervention being tested in","confidence":1,"confidence_rate":1},{"cnt":[[516,1783],[1687,1783],[1687,1828],[516,1828]],"region":{"top_left_x":515,"top_left_y":1783,"width":1172,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b402f72e36974b93a865873b8b24de8e","type":"text","conversion_output":true,"text":"the current trial. This corresponded to a mean of \\(5.0 \\%\\) vs. \\(2.6 \\%\\) weight loss over 15","text_display":" the current trial. This corresponded to a mean of \\(5.0 \\%\\) vs. \\(2.6 \\%\\) weight loss over 15","confidence":0.9960966110229492,"confidence_rate":0.9999579468296076},{"cnt":[[516,1826],[1760,1826],[1760,1880],[516,1880]],"region":{"top_left_x":515,"top_left_y":1826,"width":1245,"height":54},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9080bcd79a6e4c2cb6541e763a71785e","type":"text","conversion_output":true,"text":"months. \\({ }^{24}\\) Weight loss of \\(\\geq 5 \\%\\) is widely regarded clinically significant, \\({ }^{86}\\) while a weight","text_display":" months. \\({ }^{24}\\) Weight loss of \\(\\geq 5 \\%\\) is widely regarded clinically significant, \\({ }^{86}\\) while a weight","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[516,1878],[1760,1878],[1760,1927],[516,1927]],"region":{"top_left_x":515,"top_left_y":1877,"width":1245,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4a6e64e2a114c64b05037dc8bd34919","type":"text","conversion_output":true,"text":"change of \\(<3 \\%\\) defines weight maintenance. \\({ }^{87}\\) Hence, the net BMI lowering effect of the","text_display":" change of \\(<3 \\%\\) defines weight maintenance. \\({ }^{87}\\) Hence, the net BMI lowering effect of the","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[516,1929],[1757,1929],[1757,1979],[516,1979]],"region":{"top_left_x":515,"top_left_y":1929,"width":1243,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b62c790af3144a8a1de8e264b702c73","type":"text","conversion_output":true,"text":"intervention relates to the minimal clinically important difference in weight reduction. A","text_display":" intervention relates to the minimal clinically important difference in weight reduction. A","confidence":1,"confidence_rate":1},{"cnt":[[516,1977],[1708,1977],[1708,2024],[516,2024]],"region":{"top_left_x":515,"top_left_y":1976,"width":1194,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e0e56f6dee940c09bd0c853afb43f23","type":"text","conversion_output":true,"text":"meta-analysis of behavioral weight-loss studies reported effect sizes of \\(0.61-0.67\\) for","text_display":" meta-analysis of behavioral weight-loss studies reported effect sizes of \\(0.61-0.67\\) for","confidence":0.751953125,"confidence_rate":0.996971814541869},{"cnt":[[516,2024],[1738,2024],[1738,2073],[516,2073]],"region":{"top_left_x":515,"top_left_y":2023,"width":1224,"height":51},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7177398442c04f90a2665e7b9caebe34","type":"text","conversion_output":true,"text":"improvements in depression and self-esteem. \\({ }^{88}\\) The \\(d\\) effect sizes in the PEARLS trials","text_display":" improvements in depression and self-esteem. \\({ }^{88}\\) The \\(d\\) effect sizes in the PEARLS trials","confidence":1,"confidence_rate":1},{"cnt":[[516,2071],[1755,2071],[1755,2123],[516,2123]],"region":{"top_left_x":515,"top_left_y":2071,"width":1241,"height":52},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c89816d527e4bc5b29cddfa7148dab5","type":"text","conversion_output":true,"text":"ranged from \\(0.35-0.74 .^{32,33}\\) Further, the National Institute for Clinical Excellence in the","text_display":" ranged from \\(0.35-0.74 .^{32,33}\\) Further, the National Institute for Clinical Excellence in the","confidence":0.8013148559257388,"confidence_rate":0.9978926870264763},{"cnt":[[516,2123],[1783,2123],[1783,2172],[516,2172]],"region":{"top_left_x":515,"top_left_y":2122,"width":1269,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28f04bd4bdbe44a590963c38cfa224d9","type":"text","conversion_output":true,"text":"U.K. defines a threshold of clinical significance for depression treatment as a standardized","text_display":" U.K. defines a threshold of clinical significance for depression treatment as a standardized","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[516,2168],[810,2168],[810,2215],[516,2215]],"region":{"top_left_x":515,"top_left_y":2167,"width":295,"height":49},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4151bbb104b94152869c97e34f6d8ff3","type":"text","conversion_output":true,"text":"effect size of 0.50. \\({ }^{89}\\)","text_display":" effect size of 0.50. \\({ }^{89}\\)","confidence":0.763671875,"confidence_rate":0.9921014451417489},{"cnt":[[554,2477],[1381,2477],[1381,2516],[554,2516]],"region":{"top_left_x":554,"top_left_y":2477,"width":828,"height":39},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c903264cd3ae4917812e076b41c2c002","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999936571565041}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-14","page":14,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d6e12d316a68475ca9bd847b2f4f9ecf","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,131],[1815,131],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":131,"width":98,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"216134041f8e4a81a7b2a7ac3f72a38a","type":"page_info","conversion_output":false,"text":"Page 14","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[303,208],[655,208],[655,260],[303,260]],"region":{"top_left_x":302,"top_left_y":208,"width":354,"height":52},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2e63ff6315e48bda5c1ab28b04bf643","type":"section_header","conversion_output":false,"children_ids":["a20623e9359b456e80de772b5ed164fc"],"text":"","text_display":""},{"cnt":[[305,215],[655,215],[655,256],[305,256]],"region":{"top_left_x":305,"top_left_y":214,"width":351,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a20623e9359b456e80de772b5ed164fc","type":"text","conversion_output":true,"parent_id":"c2e63ff6315e48bda5c1ab28b04bf643","text":"2.11. 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The content is solely the","confidence":1,"confidence_rate":1},{"cnt":[[518,683],[1783,683],[1783,718],[518,718]],"region":{"top_left_x":517,"top_left_y":683,"width":1267,"height":35},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"78f8c3415d7344b8a0b2352934101a4e","type":"text","conversion_output":true,"text":"responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and","text_display":" responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and","confidence":0.99951171875,"confidence_rate":0.9999959300041316},{"cnt":[[518,718],[1815,718],[1815,750],[518,750]],"region":{"top_left_x":517,"top_left_y":717,"width":1299,"height":33},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a8355194db9d45c2aa82d4fb2f088146","type":"text","conversion_output":true,"text":"Blood Institute or the National Institutes of Health. No sponsor or funding source has a role in the design or conduct","text_display":" Blood Institute or the National Institutes of Health. No sponsor or funding source has a role in the design or conduct","confidence":0.9975595474243164,"confidence_rate":0.9999801348693963},{"cnt":[[518,752],[1815,752],[1815,784],[518,784]],"region":{"top_left_x":517,"top_left_y":751,"width":1299,"height":34},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"418a4c18206748e995c0c1661fddd2ff","type":"text","conversion_output":true,"text":"of the study; collection, management, analysis or interpretation of the data; or preparation, review or approval of the","text_display":" of the study; collection, management, analysis or interpretation of the data; or preparation, review or approval of the","confidence":1,"confidence_rate":1},{"cnt":[[516,782],[655,782],[655,819],[516,819]],"region":{"top_left_x":515,"top_left_y":782,"width":141,"height":37},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c6f7f3b3dbea4387bc8a3b4d86e5ea30","type":"text","conversion_output":true,"text":"manuscript.","text_display":" manuscript.","confidence":1,"confidence_rate":1},{"cnt":[[516,851],[1803,851],[1803,883],[516,883]],"region":{"top_left_x":515,"top_left_y":850,"width":1288,"height":34},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"49f462652daa4cb5a20574947a3d1066","type":"text","conversion_output":true,"text":"The authors dedicate this work to the deceased Wayne Katon, MD, who contributed significantly to the conception","text_display":"\n\nThe authors dedicate this work to the deceased Wayne Katon, MD, who contributed significantly to the conception","confidence":1,"confidence_rate":1},{"cnt":[[518,885],[1721,885],[1721,917],[518,917]],"region":{"top_left_x":517,"top_left_y":885,"width":1204,"height":33},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"66e848c8822848d79066f29d1b8f6a4a","type":"text","conversion_output":true,"text":"and design of the RAINBOW study. The authors extend special thanks to RAINBOW participants and their","text_display":" and design of the RAINBOW study. The authors extend special thanks to RAINBOW participants and their","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[518,915],[1792,915],[1792,950],[518,950]],"region":{"top_left_x":517,"top_left_y":915,"width":1275,"height":35},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"42b2b9d5c57d44c0ad5177be57d8434e","type":"text","conversion_output":true,"text":"families who make this study possible. The authors also thank the study physician advisors (Meg Durbin, MD, Ed","text_display":" families who make this study possible. The authors also thank the study physician advisors (Meg Durbin, MD, Ed","confidence":1,"confidence_rate":1},{"cnt":[[518,950],[1794,950],[1794,982],[518,982]],"region":{"top_left_x":517,"top_left_y":949,"width":1277,"height":33},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a380fbd0a7454edcbb33ccf1aa952b89","type":"text","conversion_output":true,"text":"Yu, MD, and Bahar Aghighi, MD), the study Data and Safety Monitoring Board members (William Haskell, PhD,","text_display":" Yu, MD, and Bahar Aghighi, MD), the study Data and Safety Monitoring Board members (William Haskell, PhD,","confidence":1,"confidence_rate":1},{"cnt":[[516,982],[1779,982],[1779,1016],[516,1016]],"region":{"top_left_x":515,"top_left_y":981,"width":1264,"height":36},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2215f6aa152e4a9685da02d18f9f0700","type":"text","conversion_output":true,"text":"Mickey Trockel, MD, Sandra Tsai, MD, and Manisha Desai, PhD), and the study team members who have made","text_display":" Mickey Trockel, MD, Sandra Tsai, MD, and Manisha Desai, PhD), and the study team members who have made","confidence":1,"confidence_rate":1},{"cnt":[[516,1014],[1785,1014],[1785,1051],[516,1051]],"region":{"top_left_x":515,"top_left_y":1014,"width":1271,"height":37},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4eae3d2e9a58441ea4464e7680f763fd","type":"text","conversion_output":true,"text":"substantial contributions to the conduct of the study (Veronica Luna, BS, Andrea Blonstein, MBA, RD, Elizabeth","text_display":" substantial contributions to the conduct of the study (Veronica Luna, BS, Andrea Blonstein, MBA, RD, Elizabeth","confidence":1,"confidence_rate":1},{"cnt":[[516,1048],[1525,1048],[1525,1081],[516,1081]],"region":{"top_left_x":515,"top_left_y":1048,"width":1011,"height":33},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fe3f084037c6455bae95c85709b26ce1","type":"text","conversion_output":true,"text":"Jameiro, MD, Nancy Wittels, MS, Elizabeth Ward, MD, and Lenard Lesser, MD, MSHS).","text_display":" Jameiro, MD, Nancy Wittels, MS, Elizabeth Ward, MD, and Lenard Lesser, MD, MSHS).","confidence":1,"confidence_rate":1},{"cnt":[[518,1117],[1807,1117],[1807,1149],[518,1149]],"region":{"top_left_x":517,"top_left_y":1117,"width":1290,"height":33},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cf367757d51f448d9c4d77866cf93241","type":"text","conversion_output":true,"text":"Investigators at Palo Alto Medical Foundation Research Institute, the University of Washington, and the University","text_display":"\n\nInvestigators at Palo Alto Medical Foundation Research Institute, the University of Washington, and the University","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[518,1147],[1738,1147],[1738,1184],[518,1184]],"region":{"top_left_x":517,"top_left_y":1147,"width":1222,"height":37},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f3cea20cff314720955c859be398d64e","type":"text","conversion_output":true,"text":"of Pittsburgh collaborated to create the RAINBOW I-CARE intervention, which integrates adaptations of the","text_display":" of Pittsburgh collaborated to create the RAINBOW I-CARE intervention, which integrates adaptations of the","confidence":1,"confidence_rate":1},{"cnt":[[518,1182],[1742,1182],[1742,1214],[518,1214]],"region":{"top_left_x":517,"top_left_y":1181,"width":1226,"height":33},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b9b5db3d17ea4aa2b61af976b1555860","type":"text","conversion_output":true,"text":"Program to Encourage Active, Rewarding Lives for Seniors and the Group Lifestyle Balance \\({ }^{\\text {TM }}\\) Program. The","text_display":" Program to Encourage Active, Rewarding Lives for Seniors and the Group Lifestyle Balance \\({ }^{\\text {TM }}\\) Program. The","confidence":0.9844324344303459,"confidence_rate":0.9998734756453472},{"cnt":[[518,1216],[1818,1216],[1818,1248],[518,1248]],"region":{"top_left_x":517,"top_left_y":1216,"width":1301,"height":33},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f4204ed0f2714907b77604b015f42d6e","type":"text","conversion_output":true,"text":"University of Washington and the University of Pittsburgh provided training and support for RAINBOW study staff","text_display":" University of Washington and the University of Pittsburgh provided training and support for RAINBOW study staff","confidence":1,"confidence_rate":1},{"cnt":[[518,1248],[1102,1248],[1102,1278],[518,1278]],"region":{"top_left_x":517,"top_left_y":1248,"width":586,"height":31},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f43be0d83c64ce4ba4fd968fb9c9acb","type":"text","conversion_output":true,"text":"at Palo Alto Medical Foundation Research Institute.","text_display":" at Palo Alto Medical Foundation Research Institute.","confidence":0.996584415435791,"confidence_rate":0.9999389048844254},{"cnt":[[305,1332],[1102,1332],[1102,1388],[305,1388]],"region":{"top_left_x":305,"top_left_y":1332,"width":798,"height":56},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1c82fce67854369bb53d177b8239a36","type":"section_header","conversion_output":false,"children_ids":["23391a909320455ab6f48642c51e3f3b"],"text":"","text_display":""},{"cnt":[[305,1336],[1096,1336],[1096,1384],[305,1384]],"region":{"top_left_x":305,"top_left_y":1336,"width":791,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23391a909320455ab6f48642c51e3f3b","type":"text","conversion_output":true,"parent_id":"e1c82fce67854369bb53d177b8239a36","text":"Appendix A. Study Medication Protocol","text_display":"\n\n\\section*{Appendix A. Study Medication Protocol}","confidence":1,"confidence_rate":1},{"cnt":[[305,1414],[1311,1414],[1311,1470],[305,1470]],"region":{"top_left_x":305,"top_left_y":1413,"width":1006,"height":57},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f0be8305fb146ab920cc3e2d1ea2aee","type":"section_header","conversion_output":false,"children_ids":["e6f82e21d811486e9d9fba6dc96de0b2"],"text":"","text_display":""},{"cnt":[[309,1418],[1308,1418],[1308,1467],[309,1467]],"region":{"top_left_x":309,"top_left_y":1417,"width":1000,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6f82e21d811486e9d9fba6dc96de0b2","type":"text","conversion_output":true,"parent_id":"0f0be8305fb146ab920cc3e2d1ea2aee","text":"I-CARE Treatment of Depression with Medications","text_display":"\n\n\\section*{I-CARE Treatment of Depression with Medications}","confidence":1,"confidence_rate":1},{"cnt":[[305,1491],[788,1491],[788,1538],[305,1538]],"region":{"top_left_x":305,"top_left_y":1491,"width":484,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"775e94fb974249ab8f2f571aa3caf866","type":"section_header","conversion_output":false,"children_ids":["9418459937634f19b172f42d7893dc39"],"text":"","text_display":""},{"cnt":[[305,1495],[784,1495],[784,1536],[305,1536]],"region":{"top_left_x":305,"top_left_y":1495,"width":480,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9418459937634f19b172f42d7893dc39","type":"text","conversion_output":true,"parent_id":"775e94fb974249ab8f2f571aa3caf866","text":"A. Initiating Antidepressants","text_display":"\n\n\\section*{A. Initiating Antidepressants}","confidence":1,"confidence_rate":1},{"cnt":[[518,1555],[1734,1555],[1734,1601],[518,1601]],"region":{"top_left_x":517,"top_left_y":1555,"width":1217,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a22f3f2dc3c04d6a8301500dc442c30b","type":"text","conversion_output":true,"text":"When starting patients on antidepressants, they need to understand that side effects can","text_display":"\n\nWhen starting patients on antidepressants, they need to understand that side effects can","confidence":1,"confidence_rate":1},{"cnt":[[518,1607],[1747,1607],[1747,1648],[518,1648]],"region":{"top_left_x":517,"top_left_y":1607,"width":1230,"height":41},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b71cef722c224619b5bd358983ea25bf","type":"text","conversion_output":true,"text":"occur before the medication's therapeutic effects help them to feel better. It is helpful to","text_display":" occur before the medication's therapeutic effects help them to feel better. 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appetite with insufficient","confidence":1,"confidence_rate":1},{"cnt":[[640,1332],[1790,1332],[1790,1377],[640,1377]],"region":{"top_left_x":640,"top_left_y":1332,"width":1150,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ec0587e1cb54417bbbeff3ad1a6a1d2","type":"text","conversion_output":true,"text":"oral intake or weight loss, suspected alcohol or drug misuse, or severe medication","text_display":" oral intake or weight loss, suspected alcohol or drug misuse, or severe medication","confidence":1,"confidence_rate":1},{"cnt":[[640,1379],[814,1379],[814,1420],[640,1420]],"region":{"top_left_x":640,"top_left_y":1379,"width":175,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22ee57a88a7d4aab8fcb07cc973b9eda","type":"text","conversion_output":true,"text":"side effects.","text_display":" side effects.","confidence":1,"confidence_rate":1},{"cnt":[[580,1448],[1534,1448],[1534,1493],[580,1493]],"region":{"top_left_x":580,"top_left_y":1448,"width":954,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7925b51121914579b3bac6ec06ad08bf","type":"text","conversion_output":true,"text":"- Create My Better Health Plan initially and update at each visit.","text_display":"\n- Create My Better Health Plan initially and update at each visit.","confidence":1,"confidence_rate":1},{"cnt":[[301,1536],[868,1536],[868,1583],[301,1583]],"region":{"top_left_x":300,"top_left_y":1536,"width":568,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"265f5cf458d2450cad5c87a52bf23f50","type":"section_header","conversion_output":false,"children_ids":["c59ef1b5d17d494ab09bd367f9e18882"],"text":"","text_display":""},{"cnt":[[305,1543],[864,1543],[864,1579],[305,1579]],"region":{"top_left_x":305,"top_left_y":1542,"width":559,"height":38},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c59ef1b5d17d494ab09bd367f9e18882","type":"text","conversion_output":true,"parent_id":"265f5cf458d2450cad5c87a52bf23f50","text":"ANTIDEPRESSANT MEDICATION","text_display":"\n\n\\section*{ANTIDEPRESSANT 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If PHQ-9 hasn't","text_display":" Fluoxetine \\(10 mg /\\) day \\(\\times 1\\) week; then \\(20 mg /\\) day \\(\\times 1\\) week. If PHQ-9 hasn't","confidence":0.8817285413620982,"confidence_rate":0.9986327719592575},{"cnt":[[578,1650],[1674,1650],[1674,1695],[578,1695]],"region":{"top_left_x":577,"top_left_y":1650,"width":1097,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ef0935e669d4f5e8042a7b32c026cf4","type":"text","conversion_output":true,"text":"decreased by \\(50 \\%\\) or more, increase to \\(30 mg /\\) day. At week 4, if PHQ-9 hasn't","text_display":" decreased by \\(50 \\%\\) or more, increase to \\(30 mg /\\) day. At week 4, if PHQ-9 hasn't","confidence":0.8473923113555443,"confidence_rate":0.9981411509942436},{"cnt":[[578,1697],[1721,1697],[1721,1745],[578,1745]],"region":{"top_left_x":577,"top_left_y":1697,"width":1144,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f7103a555464d54b283f2fce3609d7f","type":"text","conversion_output":true,"text":"decreased by \\(50 \\%\\) or more, increase to \\(40 mg /\\) day. Can increase fluoxetine up to a","text_display":" decreased by \\(50 \\%\\) or more, increase to \\(40 mg /\\) day. Can increase fluoxetine up to a","confidence":0.7301274504925459,"confidence_rate":0.9966594625802934},{"cnt":[[578,1749],[1205,1749],[1205,1794],[578,1794]],"region":{"top_left_x":577,"top_left_y":1748,"width":629,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6642b3efedee478994ef55d35eecc024","type":"text","conversion_output":true,"text":"maximum of \\(60 mg /\\) day as needed/tolerated.","text_display":" maximum of \\(60 mg /\\) day as needed/tolerated.","confidence":0.990744105540216,"confidence_rate":0.9998211891343018},{"cnt":[[580,1818],[677,1818],[677,1863],[580,1863]],"region":{"top_left_x":580,"top_left_y":1817,"width":97,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a8c8d29a22a461697f988573cd0dbce","type":"form_field","conversion_output":true,"text":"","text_display":"\n\\(\\_\\_\\_\\_\\)"},{"cnt":[[675,1818],[1721,1818],[1721,1863],[675,1863]],"region":{"top_left_x":674,"top_left_y":1817,"width":1047,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b3837e902e74c3dbf2f3d63b6265c7f","type":"text","conversion_output":true,"text":"If two or more negative SSRI trials or for those patients with preexisting","text_display":" If two or more negative SSRI trials or for those patients with preexisting","confidence":1,"confidence_rate":1},{"cnt":[[580,1867],[1764,1867],[1764,1910],[580,1910]],"region":{"top_left_x":580,"top_left_y":1866,"width":1184,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ea770721d06424c82b2938d09da9220","type":"text","conversion_output":true,"text":"diabetes-related sexual dysfunction, start Bupropion SR \\(100 mg /\\) day for 1 week; then","text_display":" diabetes-related sexual dysfunction, start Bupropion SR \\(100 mg /\\) day for 1 week; then","confidence":0.99755859375,"confidence_rate":0.9999748004067751},{"cnt":[[580,1916],[1747,1916],[1747,1962],[580,1962]],"region":{"top_left_x":580,"top_left_y":1916,"width":1167,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37463bdc7b3d4c568d8eafe1eea5213d","type":"text","conversion_output":true,"text":"\\(100 mg 2 \\times /\\) day for a week; then 200 mg in am \\& 100 mg in pm. If PHQ-9 at 4 weeks","text_display":" \\(100 mg 2 \\times /\\) day for a week; then 200 mg in am \\& 100 mg in pm. If PHQ-9 at 4 weeks","confidence":0.6590518141384948,"confidence_rate":0.9957544143933448},{"cnt":[[580,1964],[1330,1964],[1330,2009],[580,2009]],"region":{"top_left_x":580,"top_left_y":1963,"width":750,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a65ed85d44c4a4ca7099d5ca200349d","type":"text","conversion_output":true,"text":"isn't decreased by \\(50 \\%\\), increase dose to 200 mg BID.","text_display":" isn't decreased by \\(50 \\%\\), increase dose to 200 mg BID.","confidence":0.9990236759185791,"confidence_rate":0.9999852000944255},{"cnt":[[580,2032],[677,2032],[677,2078],[580,2078]],"region":{"top_left_x":580,"top_left_y":2032,"width":97,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd87bfe9939b44d49af30d0800309b15","type":"form_field","conversion_output":true,"text":"","text_display":"\n\\(\\_\\_\\_\\_\\)"},{"cnt":[[675,2035],[1732,2035],[1732,2078],[675,2078]],"region":{"top_left_x":674,"top_left_y":2034,"width":1058,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73be376132d24c26b843e693d070e6b1","type":"text","conversion_output":true,"text":"If patient doesn't fit above criteria, or has significant medical or psychiatric","text_display":" If patient doesn't fit above criteria, or has significant medical or psychiatric","confidence":1,"confidence_rate":1},{"cnt":[[580,2084],[1712,2084],[1712,2127],[580,2127]],"region":{"top_left_x":580,"top_left_y":2083,"width":1133,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"540d59eadf9a4289adeb75f108d71a1a","type":"text","conversion_output":true,"text":"symptoms, antidepressant medications to be suggested by CAREteam consulting","text_display":" symptoms, antidepressant medications to be suggested by CAREteam consulting","confidence":1,"confidence_rate":1},{"cnt":[[578,2131],[862,2131],[862,2176],[578,2176]],"region":{"top_left_x":577,"top_left_y":2131,"width":285,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6556e0a5b9a54b7997e98afe70899990","type":"text","conversion_output":true,"text":"psychiatrist or PCP.","text_display":" psychiatrist or PCP.","confidence":1,"confidence_rate":1},{"cnt":[[559,2479],[1381,2479],[1381,2516],[559,2516]],"region":{"top_left_x":558,"top_left_y":2479,"width":824,"height":37},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"374e0755fd2b4dc1b31dacf7177c2842","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-21","page":21,"lines":[{"cnt":[[266,131],[372,131],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":131,"width":106,"height":31},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"03e8b0baa056474db2e8f4aa3c8aa9df","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,129],[1815,129],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":128,"width":98,"height":38},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fd466f0f7da046e480e88a1d84f2ac36","type":"page_info","conversion_output":false,"text":"Page 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\\multicolumn{5}{|l|}{Antidepressant Medications} \\\\\n\\hline Drug & Starting dose & Usual Dose & Indications & Side Effects \\\\\n\\hline \\multicolumn{5}{|l|}{Starting antidepressants: improvement often seen in first two weeks. If not seen by 8 weeks, likely needs new agent or second agent. Check in at least weekly when starting antidepressants. \\(3 / 3\\) of people with depression will improve with antidepressants.} \\\\\n\\hline \\multicolumn{5}{|c|}{Stopping antidepressants: Recurrence of depression is common. \\(64 \\%\\) of patients with depression had a recurrence 10 years after stopping their antidepressants. If patients do decide to stop their antidepressants, encourage them to talk with their PCP prior to stopping and help them understand that there are fewer problems when antidepressant dosages are tapered over a two week period.} \\\\\n\\hline \\multicolumn{5}{|l|}{Selective serotonin reuptake inhibitors (SSRIs)} \\\\\n\\hline Citalopram (Celexa) & 10 & 20-40 & Max FDA daily recommended dose for patients \\(>60 yrs\\) old is 20 mg & \\multirow[t]{3}{*}{Jitteriness, restlessness, agitation, GI distress, nausea, diarrhea, insomnia usually improve in 2 weeks. Weight gain for some patients.} \\\\\n\\hline Fluoxetine (Prozac) & 10 & 20-60 & First line (weight gain less likely) & \\\\\n\\hline Fluvoxamine (Luvox) & 50 & 50-300 & & \\\\\n\\hline Paroxetine (Paxil) & 20 & 20-60 & Worst for sexual dysfunction, weight gain, sedation; mild anticholinergic effects (helps diarrhea) & Same as above. \\\\\n\\hline Paroxetine CR (Paxil CR) & 25 & 25-75 & & Same as above. \\\\\n\\hline Sertraline (Zoloft) & 50 & 50-200 & & Same as above. \\\\\n\\hline \\multicolumn{5}{|l|}{Dopamine-norepinephrine reuptake inhibitors} \\\\\n\\hline Bupropion SR (Wellbutrin SR) **When dose > 100 mg give bid. & 100 & 300-400 & Weight gain rare. May improve sexual functioning. Useful for lethargic patients. & Contraindicated in patients with seizure history or eating disorders. \\\\\n\\hline \\multicolumn{5}{|l|}{Serotonin-norepinephrine reuptake inhibitors (SNRIs)} \\\\\n\\hline \\begin{tabular}{l}\nVenlafaxine XR (Effexor XR) \\\\\n**When dose \\(>75\\) mg, give bid.\n\\end{tabular} & 37.5, 75 \\& 100 & 75-300 & & Effective for diabetic neuropathy, fibromyalgia, chronic pain. \\\\\n\\hline Duloxetine (Cymbalta)— & 30 & 60-120 & & Effective for diabetic neuropathy, fibromyalgia, chronic pain. \\\\\n\\hline \\multicolumn{5}{|l|}{Serotonin modulators} \\\\\n\\hline Trazodone (Desyrel) & 25-50 & 50-300 & Useful for insomnia associated with depression/ anxiety. & Doses \\(>50 mg\\) can cause orthostatic hypotension or (rarely) priapism. \\\\\n\\hline \\multicolumn{5}{|l|}{Tricyclics and tetracyclics} \\\\\n\\hline Amitriptyline (Elavil) & 25-50 & 100-300 & & \\multirow{4}{*}{Anticholinergic side effects and weight gain. Elders particularly susceptible to memory change, confusion, hallucinations, sedation} \\\\\n\\hline Amoxapine (Asendin) & 50 & 100-400 & & \\\\\n\\hline Clomipramine (Anafranil) & 25 & 100-250 & & \\\\\n\\hline Maprotiline (Ludiomil) & 50 & 100-225 & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline \\multicolumn{5}{|l|}{Antidepressant Medications} \\\\\n\\hline Drug & Starting dose & Usual Dose & Indications & Side Effects \\\\\n\\hline \\multicolumn{5}{|l|}{Starting antidepressants: improvement often seen in first two weeks. If not seen by 8 weeks, likely needs new agent or second agent. Check in at least weekly when starting antidepressants. \\(3 / 3\\) of people with depression will improve with antidepressants.} \\\\\n\\hline \\multicolumn{5}{|c|}{Stopping antidepressants: Recurrence of depression is common. \\(64 \\%\\) of patients with depression had a recurrence 10 years after stopping their antidepressants. If patients do decide to stop their antidepressants, encourage them to talk with their PCP prior to stopping and help them understand that there are fewer problems when antidepressant dosages are tapered over a two week period.} \\\\\n\\hline \\multicolumn{5}{|l|}{Selective serotonin reuptake inhibitors (SSRIs)} \\\\\n\\hline Citalopram (Celexa) & 10 & 20-40 & Max FDA daily recommended dose for patients \\(>60 yrs\\) old is 20 mg & \\multirow[t]{3}{*}{Jitteriness, restlessness, agitation, GI distress, nausea, diarrhea, insomnia usually improve in 2 weeks. Weight gain for some patients.} \\\\\n\\hline Fluoxetine (Prozac) & 10 & 20-60 & First line (weight gain less likely) & \\\\\n\\hline Fluvoxamine (Luvox) & 50 & 50-300 & & \\\\\n\\hline Paroxetine (Paxil) & 20 & 20-60 & Worst for sexual dysfunction, weight gain, sedation; mild anticholinergic effects (helps diarrhea) & Same as above. \\\\\n\\hline Paroxetine CR (Paxil CR) & 25 & 25-75 & & Same as above. \\\\\n\\hline Sertraline (Zoloft) & 50 & 50-200 & & Same as above. \\\\\n\\hline \\multicolumn{5}{|l|}{Dopamine-norepinephrine reuptake inhibitors} \\\\\n\\hline Bupropion SR (Wellbutrin SR) **When dose > 100 mg give bid. & 100 & 300-400 & Weight gain rare. May improve sexual functioning. Useful for lethargic patients. & Contraindicated in patients with seizure history or eating disorders. \\\\\n\\hline \\multicolumn{5}{|l|}{Serotonin-norepinephrine reuptake inhibitors (SNRIs)} \\\\\n\\hline \\begin{tabular}{l}\nVenlafaxine XR (Effexor XR) \\\\\n**When dose \\(>75\\) mg, give bid.\n\\end{tabular} & 37.5, 75 \\& 100 & 75-300 & & Effective for diabetic neuropathy, fibromyalgia, chronic pain. \\\\\n\\hline Duloxetine (Cymbalta)— & 30 & 60-120 & & Effective for diabetic neuropathy, fibromyalgia, chronic pain. \\\\\n\\hline \\multicolumn{5}{|l|}{Serotonin modulators} \\\\\n\\hline Trazodone (Desyrel) & 25-50 & 50-300 & Useful for insomnia associated with depression/ anxiety. & Doses \\(>50 mg\\) can cause orthostatic hypotension or (rarely) priapism. \\\\\n\\hline \\multicolumn{5}{|l|}{Tricyclics and tetracyclics} \\\\\n\\hline Amitriptyline (Elavil) & 25-50 & 100-300 & & \\multirow{4}{*}{Anticholinergic side effects and weight gain. 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The research staff will generate daily reports (except for weekends and holidays)","text_display":"\n2. 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For example, these may include treatment retention rates and","text_display":" between treatment groups. For example, these may include treatment retention rates and","confidence":1,"confidence_rate":1},{"cnt":[[516,1152],[1777,1152],[1777,1192],[516,1192]],"region":{"top_left_x":515,"top_left_y":1151,"width":1262,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4eeb4d3a83a04c41803d9175b064555d","type":"text","conversion_output":true,"text":"reasons for drop-outs. In addition, mean (SD) changes in SCL-20 score, weight, BMI, and","text_display":" reasons for drop-outs. In addition, mean (SD) changes in SCL-20 score, weight, BMI, and","confidence":1,"confidence_rate":1},{"cnt":[[518,1199],[1772,1199],[1772,1244],[518,1244]],"region":{"top_left_x":517,"top_left_y":1198,"width":1256,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"369bc80527084ea88882549256724719","type":"text","conversion_output":true,"text":"cardiovascular risk factors from baseline to follow-up will be reported for all participants,","text_display":" cardiovascular risk factors from baseline to follow-up will be reported for all participants,","confidence":1,"confidence_rate":1},{"cnt":[[516,1250],[1764,1250],[1764,1291],[516,1291]],"region":{"top_left_x":515,"top_left_y":1250,"width":1249,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9a72694fe06470295042f54bc344907","type":"text","conversion_output":true,"text":"irrespective of random assignment, because as noted above, interim outcome analyses by","text_display":" irrespective of random assignment, because as noted above, interim outcome analyses by","confidence":1,"confidence_rate":1},{"cnt":[[516,1298],[995,1298],[995,1338],[516,1338]],"region":{"top_left_x":515,"top_left_y":1297,"width":480,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b84e780771a4f50b7c49e5cf6477456","type":"text","conversion_output":true,"text":"group are not planned in this trial.","text_display":" group are not planned in this trial.","confidence":1,"confidence_rate":1},{"cnt":[[305,1384],[681,1384],[681,1433],[305,1433]],"region":{"top_left_x":305,"top_left_y":1383,"width":377,"height":51},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45e4fbb37747427cbf08da227c3d1786","type":"section_header","conversion_output":false,"children_ids":["a1f3fb62c605473bb471b70c5c5dfa0d"],"text":"","text_display":""},{"cnt":[[309,1388],[677,1388],[677,1429],[309,1429]],"region":{"top_left_x":309,"top_left_y":1387,"width":368,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1f3fb62c605473bb471b70c5c5dfa0d","type":"text","conversion_output":true,"parent_id":"45e4fbb37747427cbf08da227c3d1786","text":"Study Stopping Rules","text_display":"\n\n\\section*{Study Stopping Rules}","confidence":1,"confidence_rate":1},{"cnt":[[516,1450],[1708,1450],[1708,1493],[516,1493]],"region":{"top_left_x":515,"top_left_y":1450,"width":1194,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd6411a8006b470fb40b99a1bb3d0b9b","type":"text","conversion_output":true,"text":"Formal stopping rules for safety, efficacy, and futility are not proposed as part of this","text_display":"\n\nFormal stopping rules for safety, efficacy, and futility are not proposed as part of this","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[516,1500],[1704,1500],[1704,1540],[516,1540]],"region":{"top_left_x":515,"top_left_y":1499,"width":1189,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c19e2b5702bb4d98bb76fa58839811e8","type":"text","conversion_output":true,"text":"application but may be established per recommendations of the DSMB following the","text_display":" application but may be established per recommendations of the DSMB following the","confidence":1,"confidence_rate":1},{"cnt":[[516,1547],[1815,1547],[1815,1590],[516,1590]],"region":{"top_left_x":515,"top_left_y":1546,"width":1301,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"376e1ec0bf054e519e0cc48b6b7e8127","type":"text","conversion_output":true,"text":"funding of the grant. If at any time during the course of the study, the DSMB judges that risk","text_display":" funding of the grant. 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Faith MS, Butryn M, Wadden TA, Fabricatore A, Nguyen AM, Heymsfield SB. Evidence for","text_display":"\n1. Faith MS, Butryn M, Wadden TA, Fabricatore A, Nguyen AM, Heymsfield SB. Evidence for","confidence":1,"confidence_rate":1},{"cnt":[[552,473],[1742,473],[1742,509],[552,509]],"region":{"top_left_x":552,"top_left_y":472,"width":1191,"height":38},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96a591592bb649ae95148bdad1823279","type":"text","conversion_output":true,"text":"prospective associations among depression and obesity in population-based studies. Obes Rev.","text_display":" prospective associations among depression and obesity in population-based studies. Obes Rev.","confidence":1,"confidence_rate":1},{"cnt":[[552,511],[1188,511],[1188,548],[552,548]],"region":{"top_left_x":552,"top_left_y":511,"width":637,"height":37},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2456eaaac7d746b9b801bbf477125918","type":"text","conversion_output":true,"text":"May; 2011 12(5):e438-453. [PubMed: 21414128]","text_display":" May; 2011 12(5):e438-453. [PubMed: 21414128]","confidence":0.9560546875,"confidence_rate":0.99913613943739},{"cnt":[[518,554],[1798,554],[1798,591],[518,591]],"region":{"top_left_x":517,"top_left_y":554,"width":1282,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9beda822502d41e9bbaa23281ae65883","type":"text","conversion_output":true,"text":"2. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of","text_display":"\n2. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of","confidence":1,"confidence_rate":1},{"cnt":[[552,593],[1764,593],[1764,632],[552,632]],"region":{"top_left_x":552,"top_left_y":592,"width":1212,"height":40},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fed41591148244f8801c311b51325db6","type":"text","conversion_output":true,"text":"body mass index among US adults, 1999-2010. JAMA. Feb 1; 2012 307(5):491-497. [PubMed:","text_display":" body mass index among US adults, 1999-2010. JAMA. Feb 1; 2012 307(5):491-497. [PubMed:","confidence":1,"confidence_rate":1},{"cnt":[[550,632],[694,632],[694,672],[550,672]],"region":{"top_left_x":550,"top_left_y":631,"width":144,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b665dd436c394923b1d13b13c91012f6","type":"text","conversion_output":true,"text":"22253363]","text_display":" 22253363]","confidence":1,"confidence_rate":1},{"cnt":[[516,679],[1811,679],[1811,715],[516,715]],"region":{"top_left_x":515,"top_left_y":678,"width":1297,"height":38},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a48bae7c1af43099683c5dd4d32a069","type":"text","conversion_output":true,"text":"3. Nguyen NT, Nguyen XM, Lane J, Wang P. Relationship between obesity and diabetes in a US adult","text_display":"\n3. Nguyen NT, Nguyen XM, Lane J, Wang P. 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Design and methods for a randomized clinical trial","confidence":1,"confidence_rate":1},{"cnt":[[569,1603],[1794,1603],[1794,1639],[569,1639]],"region":{"top_left_x":569,"top_left_y":1602,"width":1225,"height":38},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"aa05517d10344276895c645dfedc21e8","type":"text","conversion_output":true,"text":"treating comorbid obesity and major depressive disorder. BMC Psychiatry. 2008; 8:77. [PubMed:","text_display":" treating comorbid obesity and major depressive disorder. BMC Psychiatry. 2008; 8:77. 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The Pathways Study: a randomized trial of collaborative","confidence":1,"confidence_rate":1},{"cnt":[[571,1723],[1798,1723],[1798,1760],[571,1760]],"region":{"top_left_x":571,"top_left_y":1723,"width":1228,"height":37},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"861a2e85e8774701a4a438d3559d8020","type":"text","conversion_output":true,"text":"care in patients with diabetes and depression. Arch Gen Psychiatry. Oct; 2004 61(10):1042-1049.","text_display":" care in patients with diabetes and depression. Arch Gen Psychiatry. Oct; 2004 61(10):1042-1049.","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[571,1762],[844,1762],[844,1798],[571,1798]],"region":{"top_left_x":571,"top_left_y":1761,"width":274,"height":38},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c137f3d4a8c24d39a00dbda90232f462","type":"text","conversion_output":true,"text":"[PubMed: 15466678]","text_display":" [PubMed: 15466678]","confidence":1,"confidence_rate":1},{"cnt":[[518,1805],[1798,1805],[1798,1841],[518,1841]],"region":{"top_left_x":517,"top_left_y":1804,"width":1282,"height":38},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5bca9fb2f9894031968fe67f36bf0487","type":"text","conversion_output":true,"text":"97. Unutzer J, Katon W, Callahan CM, et al. Collaborative care management of late-life depression in","text_display":"\n97. Unutzer J, Katon W, Callahan CM, et al. Collaborative care management of late-life depression in","confidence":1,"confidence_rate":1},{"cnt":[[569,1843],[1798,1843],[1798,1880],[569,1880]],"region":{"top_left_x":569,"top_left_y":1843,"width":1230,"height":37},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"db33e2dbfa5d4b62a38fa8920eb91faa","type":"text","conversion_output":true,"text":"the primary care setting: a randomized controlled trial. JAMA. Dec 11; 2002 288(22):2836-2845.","text_display":" the primary care setting: a randomized controlled trial. JAMA. Dec 11; 2002 288(22):2836-2845.","confidence":1,"confidence_rate":1},{"cnt":[[571,1882],[844,1882],[844,1919],[571,1919]],"region":{"top_left_x":571,"top_left_y":1882,"width":274,"height":37},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e310cc1c38da4c218b93db3f3e88069e","type":"text","conversion_output":true,"text":"[PubMed: 12472325]","text_display":" [PubMed: 12472325]","confidence":1,"confidence_rate":1},{"cnt":[[518,1927],[1807,1927],[1807,1966],[518,1966]],"region":{"top_left_x":517,"top_left_y":1927,"width":1290,"height":39},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9cc8f3567a3d48a881e5f6ce71a3063f","type":"text","conversion_output":true,"text":"98. Katon W, Pedersen HS, Ribe AR, et al. Effect of Depression and Diabetes Mellitus on the Risk for","text_display":"\n98. Katon W, Pedersen HS, Ribe AR, et al. Effect of Depression and Diabetes Mellitus on the Risk for","confidence":1,"confidence_rate":1},{"cnt":[[569,1964],[1669,1964],[1669,2004],[569,2004]],"region":{"top_left_x":569,"top_left_y":1963,"width":1101,"height":42},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1e793d55dad44d37a1897f52615bbffc","type":"text","conversion_output":true,"text":"Dementia: A National Population-Based Cohort Study. JAMA psychiatry. Apr 15.2015","text_display":" Dementia: A National Population-Based Cohort Study. JAMA psychiatry. Apr 15.2015","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[559,2479],[1381,2479],[1381,2514],[559,2514]],"region":{"top_left_x":558,"top_left_y":2479,"width":824,"height":35},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e047923b1d1a432da3d59723ab7157be","type":"page_info","conversion_output":false,"text":"Contemp Clin Trials. Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"85fc35e0-71df-4699-9a58-76d90d77b52d-37","page":37,"lines":[{"cnt":[[266,133],[372,133],[372,161],[266,161]],"region":{"top_left_x":266,"top_left_y":133,"width":106,"height":29},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ffa8773edcd54c70a5e03fb314656428","type":"page_info","conversion_output":false,"text":"Ma et al.","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999651148586358},{"cnt":[[1719,133],[1815,133],[1815,165],[1719,165]],"region":{"top_left_x":1718,"top_left_y":133,"width":98,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ad4d61bd70db47dabdcfbdb9d89a4683","type":"page_info","conversion_output":false,"text":"Page 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& Prescreening (Electronic health record data) & PCP Clearance & Screening (Patient reports by phone or online) & Baseline Visit (In-person interview, physical exam and, if clinically indicated, study physician clearance) \\\\\n\\hline Inclusion Criteria: (patients will be included if meeting all of the following) & & & & \\\\\n\\hline Ethnicity: All ethnic groups & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Gender: Both men and women & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Age: \\(\\geq 18\\) years & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Body mass index \\(\\geq 30.0 kg / m ^{2}\\) (non-Asians) or \\(\\geq 27.0 kg / m ^{2}\\) (Asians) & \\(\\sqrt{ }\\) & & & \\(\\sqrt{ }\\) \\\\\n\\hline Clinically significant depression PHQ-9 \\(\\geq 10\\) & & & \\(\\sqrt{ }\\) & \\\\\n\\hline PAMF patient for \\(\\geq 1\\) year and seen in primary care at least once in the preceding 24 months & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Able and willing to enroll and provide written, informed consent, i.e., to: meet the time and data collection requirements of the study; be randomized to one of two intervention arms; participate in follow-up for 24 months; and allow extraction of relevant information from their medical records. & & & & \\(\\sqrt{ }\\) \\\\\n\\hline Exclusion Criteria: (patients will be excluded if meeting any of the following) & & & & \\\\\n\\hline Active suicidal ideation per PHQ-9 interview that includes active plan and/or intent (item \\#9 \\(\\geq 2\\) ) & & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Any Axis I disorder other than Minor or Major Depressive Disorder and/or Dysthymia, with the exception of any comorbid Anxiety Disorder & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & & \\\\\n\\hline Active Bulimia Nervosa within the past 3 months (however Binge Eating Disorder without purging is not an exclusionary condition) & & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Active alcohol or substance use disorder (including prescription drugs) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Ongoing psychiatric care with a provider outside of PAMF & & & \\(\\sqrt{ }\\) & \\\\\n\\hline Had bariatric surgery within the past 12 months or plan to undergo bariatric surgery during the study period & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Pre-existing diabetes (other than during pregnancy) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) \\\\\n\\hline Pre-existing cardiovascular disease: e.g., coronary heart disease (myocardial infarction, angina pectoris, percutaneous coronary intervention, and coronary artery bypass graft surgery), cerebrovascular disease (stroke, transient ischemic attack), peripheral vascular disease, heart failure, or aortic aneurysm. & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) \\\\\n\\hline Diagnosis of cancer (other than non-melanoma skin cancer) that is/was active or treated with radiation or chemotherapy within the past year & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Severe medical comorbidities that require aggressive treatment, e.g., stage 4 or greater renal disease, liver failure & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Diagnosis of a terminal illness and/or residence in a long-term care facility & & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Cognitive impairment based on the Callahan 6-item screener & & & & \\(\\sqrt{ }\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|}\n\\hline & Prescreening (Electronic health record data) & PCP Clearance & Screening (Patient reports by phone or online) & Baseline Visit (In-person interview, physical exam and, if clinically indicated, study physician clearance) \\\\\n\\hline Inclusion Criteria: (patients will be included if meeting all of the following) & & & & \\\\\n\\hline Ethnicity: All ethnic groups & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Gender: Both men and women & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Age: \\(\\geq 18\\) years & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Body mass index \\(\\geq 30.0 kg / m ^{2}\\) (non-Asians) or \\(\\geq 27.0 kg / m ^{2}\\) (Asians) & \\(\\sqrt{ }\\) & & & \\(\\sqrt{ }\\) \\\\\n\\hline Clinically significant depression PHQ-9 \\(\\geq 10\\) & & & \\(\\sqrt{ }\\) & \\\\\n\\hline PAMF patient for \\(\\geq 1\\) year and seen in primary care at least once in the preceding 24 months & \\(\\sqrt{ }\\) & & & \\\\\n\\hline Able and willing to enroll and provide written, informed consent, i.e., to: meet the time and data collection requirements of the study; be randomized to one of two intervention arms; participate in follow-up for 24 months; and allow extraction of relevant information from their medical records. & & & & \\(\\sqrt{ }\\) \\\\\n\\hline Exclusion Criteria: (patients will be excluded if meeting any of the following) & & & & \\\\\n\\hline Active suicidal ideation per PHQ-9 interview that includes active plan and/or intent (item \\#9 \\(\\geq 2\\) ) & & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Any Axis I disorder other than Minor or Major Depressive Disorder and/or Dysthymia, with the exception of any comorbid Anxiety Disorder & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & & \\\\\n\\hline Active Bulimia Nervosa within the past 3 months (however Binge Eating Disorder without purging is not an exclusionary condition) & & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Active alcohol or substance use disorder (including prescription drugs) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Ongoing psychiatric care with a provider outside of PAMF & & & \\(\\sqrt{ }\\) & \\\\\n\\hline Had bariatric surgery within the past 12 months or plan to undergo bariatric surgery during the study period & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\\\\n\\hline Pre-existing diabetes (other than during pregnancy) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) & \\(\\sqrt{ }\\) 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Week & Visit \\({ }^{c}\\) & Minutes & Content \\\\\n\\hline 1 & 1 & 60 & \\begin{tabular}{l}\n- Introduction to I-CARE Mood and I-CARE Lifestyle \\({ }^{d}\\) sequenced integration (5 min) \\\\\n- Technology: Fitbit, MyFitnessPal - using, linking, friend requests to coach; My Health Online. \\({ }^{e}\\) Encouragement to wear Fitbit and check uploads ( 10 min ) \\\\\n- Physical activity safety guidelines handout (GLB Session 4, pages 3,4) \\\\\n- Evaluation of bathroom scale ownership \\\\\n- I-CARE Mood Session 1 ( 45 min )\n\\end{tabular} \\\\\n\\hline 2 & 2 & 60 & \\begin{tabular}{l}\n- I-CARE Mood Session 2 ( 60 min ) \\\\\n- Provision of bathroom scale to participants requiring one\n\\end{tabular} \\\\\n\\hline 3 & 3 & 60 & - I-CARE Mood Session 3 ( 60 min ) \\\\\n\\hline 4 & 4 & 60 & \\begin{tabular}{l}\n- I-CARE Mood Session 4 ( 50 min ) \\\\\n- Technology: MyFitnessPal - explanation of logging physical activity minutes and weight; introduction to logging diet; importance of self-monitoring ( 10 min )\n\\end{tabular} \\\\\n\\hline 6 & 5 & 60 & \\begin{tabular}{l}\n- I-CARE Mood Session 5 ( 45 min ) \\\\\n- I-CARE Lifestyle introduction and self-study guidelines (5 min) \\\\\n- Technology: MyFitnessPal - review of logging physical activity and weight; explanation of logging diet; importance of self-monitoring ( 10 min )\n\\end{tabular} \\\\\n\\hline 8 & 6 & 60 & \\begin{tabular}{l}\n- I-CARE Lifestyle Progress Check ( 5 min ) \\\\\n- I-CARE Mood Session 6 ( 30 min ) \\\\\n- Technology: MyFitnessPal, Fitbit, My Health Online check in (5 min) \\\\\n- Goals confirmation: weight, physical activity, steps (5 min) \\\\\n- Optional tools to reduce calorie intake: meal plans, packaged meals (5 min) \\\\\n- I-CARE Lifestyle Session (GLB Sessions \\#1,2) (10 min)\n\\end{tabular} \\\\\n\\hline 12 & 7 & 60 & \\begin{tabular}{l}\n- I-CARE Lifestyle Progress Check ( 10 min) \\\\\n- I-CARE Mood Session 7 ( 35 min ) \\\\\n- I-CARE Lifestyle Session (GLB Sessions 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sequenced integration (5 min) \\\\\n- Technology: Fitbit, MyFitnessPal - using, linking, friend requests to coach; My Health Online. \\({ }^{e}\\) Encouragement to wear Fitbit and check uploads ( 10 min ) \\\\\n- Physical activity safety guidelines handout (GLB Session 4, pages 3,4) \\\\\n- Evaluation of bathroom scale ownership \\\\\n- I-CARE Mood Session 1 ( 45 min )\n\\end{tabular} \\\\\n\\hline 2 & 2 & 60 & \\begin{tabular}{l}\n- I-CARE Mood Session 2 ( 60 min ) \\\\\n- Provision of bathroom scale to participants requiring one\n\\end{tabular} \\\\\n\\hline 3 & 3 & 60 & - I-CARE Mood Session 3 ( 60 min ) \\\\\n\\hline 4 & 4 & 60 & \\begin{tabular}{l}\n- I-CARE Mood Session 4 ( 50 min ) \\\\\n- Technology: MyFitnessPal - explanation of logging physical activity minutes and weight; introduction to logging diet; importance of self-monitoring ( 10 min )\n\\end{tabular} \\\\\n\\hline 6 & 5 & 60 & \\begin{tabular}{l}\n- I-CARE Mood Session 5 ( 45 min ) \\\\\n- I-CARE Lifestyle introduction and self-study guidelines (5 min) \\\\\n- Technology: MyFitnessPal - review of logging physical activity and weight; explanation of logging diet; importance of self-monitoring ( 10 min )\n\\end{tabular} \\\\\n\\hline 8 & 6 & 60 & \\begin{tabular}{l}\n- I-CARE Lifestyle Progress Check ( 5 min ) \\\\\n- I-CARE Mood Session 6 ( 30 min ) \\\\\n- Technology: MyFitnessPal, Fitbit, My Health Online check in (5 min) \\\\\n- Goals confirmation: weight, physical activity, steps (5 min) \\\\\n- Optional tools to reduce calorie intake: meal plans, packaged meals (5 min) \\\\\n- I-CARE Lifestyle Session (GLB Sessions \\#1,2) (10 min)\n\\end{tabular} \\\\\n\\hline 12 & 7 & 60 & \\begin{tabular}{l}\n- I-CARE Lifestyle Progress Check ( 10 min) \\\\\n- I-CARE Mood Session 7 ( 35 min ) \\\\\n- I-CARE Lifestyle Session (GLB Sessions \\#3,4,5,6) (15 min)\n\\end{tabular} \\\\\n\\hline 16 & 8 & 60 & \\begin{tabular}{l}\n- I-CARE Lifestyle Progress Check ( 10 min) \\\\\n- I-CARE Mood Session 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\\multirow{2}{*}{Study Measures} & \\multirow{2}{*}{Instrument} & \\multirow{2}{*}{Collection Method} & \\multicolumn{6}{|c|}{Month} \\\\\n\\hline & & & Screening & 0 & 6 & 12 & 18 & 24 \\\\\n\\hline \\multicolumn{9}{|c|}{} \\\\\n\\hline Depression severity & Patient Health Questionnaire-9 (PHQ-9 and Dysthymia questions) & Self-report & x & & & & & \\\\\n\\hline Suicidal ideation & PHQ-9 (item \\#9 \\(\\geq 2\\) ) & Self-report & x & & & & & \\\\\n\\hline Bulimia nervosa & PHQ eating disorder module & Self-report & x & & & & & \\\\\n\\hline Alcohol/substance abuse & CAGE Adapted to Include Drugs (CAGE-AID) & Self-report & x & & & & & \\\\\n\\hline Cognitive Impairment & 6-item Screener & Interview & & x & & & & \\\\\n\\hline \\multicolumn{9}{|c|}{Primary/Secondary Outcomes} \\\\\n\\hline BMI (height) & Height & Biophysical & & x & & & & \\\\\n\\hline BMI (weight) & Weight & Biophysical & & & x x & x & x & x \\\\\n\\hline Depression severity treatment response, and remission & Depression symptom Checklist-20 (SCL-20) & Self-report & & x & x & x & x & x \\\\\n\\hline Cardiovascular risk factors & Blood pressure, waist circumference & Biophysical & & x & x & x & x & x \\\\\n\\hline Obesity-specific health related questions & Obesity-related Problem Scale & Self-report & & x & x & x & x & x \\\\\n\\hline Anxiety & Generalized Anxiety Disorder Scale (GAD-7); Panic Disorder module of the Mini-International Neuropsychiatric Interview (MINI) & Self-report & & x & x & x & x & x \\\\\n\\hline Disability & Sheehan Disability Scale & Self-report & & x & x & x & x & x \\\\\n\\hline Generic health related quality of life & SF-8 Health Survey & Self-report & & x & x & x & x & x \\\\\n\\hline Utility based quality of life & EuroQOL-5D-5L & Self-report & & x & x & x & x & x \\\\\n\\hline \\multirow{5}{*}{Direct medical costs, direct nonmedical costs} & Health care utilization: from electronic health record (EHR); intervention cost: coach time, survey lifestyle coach for Intervention process accounting, intervention-related patient \"out-of-pocket\" costs. & EHR; process documentation; self-report & & x & x & x & x & x \\\\\n\\hline & Absenteeism-Presenteeism questionnaire & Self-report & & x & x & x & x & x \\\\\n\\hline & Participant Expense Survey & Self-report & & x & x & x & x & x \\\\\n\\hline & Medication use, general wellness services, and out of network health care utilization questionnaire & Interview & & x & x & x & x & x \\\\\n\\hline & \\multicolumn{8}{|c|}{Potential effect modifiers} \\\\\n\\hline Sociodemographics & Age, gender, education, race/ethnicity & Self-report & & x & & & & \\\\\n\\hline Posttraumatic stress disorder (PTSD) & 17-item PTSD checklist - Civilian Version (PCL-C) & Self-report & & x & & & & \\\\\n\\hline \\multicolumn{9}{|c|}{Potential effect mediators} \\\\\n\\hline Dietary intake & 24-hr diet recalls & Interview & & x & x & x & x & x \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|l|}\n\\hline \\multirow{2}{*}{Study Measures} & \\multirow{2}{*}{Instrument} & \\multirow{2}{*}{Collection Method} & \\multicolumn{6}{|c|}{Month} \\\\\n\\hline & & & Screening & 0 & 6 & 12 & 18 & 24 \\\\\n\\hline \\multicolumn{9}{|c|}{} \\\\\n\\hline Depression severity & Patient Health Questionnaire-9 (PHQ-9 and Dysthymia questions) & Self-report & x & & & & & \\\\\n\\hline Suicidal ideation & PHQ-9 (item \\#9 \\(\\geq 2\\) ) & Self-report & x & & & & & \\\\\n\\hline Bulimia nervosa & PHQ eating disorder module & Self-report & x & & & & & \\\\\n\\hline Alcohol/substance abuse & CAGE Adapted to Include Drugs (CAGE-AID) & Self-report & x & & & & & \\\\\n\\hline Cognitive Impairment & 6-item Screener & Interview & & x & & & & \\\\\n\\hline \\multicolumn{9}{|c|}{Primary/Secondary Outcomes} \\\\\n\\hline BMI (height) & Height & Biophysical & & x & & & & \\\\\n\\hline BMI (weight) & Weight & Biophysical & & & x x & x & x & x \\\\\n\\hline Depression severity treatment response, and remission & Depression symptom Checklist-20 (SCL-20) & Self-report & & x & x & x & x & x \\\\\n\\hline Cardiovascular risk factors & Blood pressure, waist circumference & Biophysical & & x & x & x & x & x \\\\\n\\hline Obesity-specific health related questions & Obesity-related Problem Scale & Self-report & & x & x & x & x & x \\\\\n\\hline Anxiety & Generalized Anxiety Disorder Scale (GAD-7); Panic Disorder module of the Mini-International Neuropsychiatric Interview (MINI) & Self-report & & x & x & x & x & x \\\\\n\\hline Disability & Sheehan Disability Scale & Self-report & & x & x & x & x & x \\\\\n\\hline Generic health related quality of life & SF-8 Health Survey & Self-report & & x & x & x & x & x \\\\\n\\hline Utility based quality of life & EuroQOL-5D-5L & Self-report & & x & x & x & x & x \\\\\n\\hline \\multirow{5}{*}{Direct medical costs, direct nonmedical costs} & Health care utilization: from electronic health record (EHR); intervention cost: coach time, survey lifestyle coach for Intervention process accounting, intervention-related patient \"out-of-pocket\" costs. & EHR; process documentation; self-report & & x & x & x & x & x \\\\\n\\hline & Absenteeism-Presenteeism questionnaire & Self-report & & x & x & x & x & x \\\\\n\\hline & Participant Expense Survey & Self-report & & x & x & x & x & x \\\\\n\\hline & Medication use, general wellness services, and out of network health care utilization questionnaire & Interview & & x & x & x & x & x \\\\\n\\hline & \\multicolumn{8}{|c|}{Potential effect modifiers} \\\\\n\\hline Sociodemographics & Age, gender, education, race/ethnicity & Self-report & & x & & & & \\\\\n\\hline Posttraumatic stress disorder (PTSD) & 17-item PTSD checklist - Civilian Version (PCL-C) & Self-report & & x & & & & \\\\\n\\hline \\multicolumn{9}{|c|}{Potential effect mediators} \\\\\n\\hline Dietary intake & 24-hr diet recalls & Interview & & x & x & x & 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Was there variability in these factors related to demographics or other characteristics? How were the barriers addressed? Were the solutions successful? What could be changed to maximize reach? \\\\\n\\hline Adoption & Using administrative data we will describe the characteristics of participating clinics, and the percentage and characteristics of PCPs approached that participated (e.g., PCPs referring patients for screening or making recommended antidepressant medication changes). & Via interviews with internal experts, PCPs, and medical and administrative leaders we will ask: What were the barriers to and enablers of clinic and PCP participation? Why did the barriers exist? What recommendations do they have for addressing barriers and maximizing adoption? \\\\\n\\hline Implementation (staff perspective) & Using intervention tracking data we will assess time and resources required for coach training, intervention delivery, coach supervision, and fidelity assurance. & Via interviews with study care team, internal experts, PCPs, and medical and administrative leaders we will ask: What were the barriers to and enablers of delivering the intervention, and were they different across participating clinics? How might these factors translate or not to real-world implementation? Were certain components more challenging to deliver than others? What modifications could be made to maximize realworld implementation? \\\\\n\\hline Implementation (patient perspective) & Using intervention tracking data we will assess participants' receipt of and adherence to the intervention, e.g., by monitoring the number of in-person sessions, phone calls and DVD sessions completed, reasons for missed sessions, secure email and self-monitoring frequency, and consistency of adherence across participant subgroups. & Via interviews with a \\(10 \\%\\) random sample of intervention participants we will ask: How relevant and acceptable were the knowledge and skills gained? How often did they practice the intervention strategies? What were the perceived benefits? What problems did they encounter? How satisfied were they with program format, materials, and coach performance? \\\\\n\\hline Maintenance & Using follow-up data through 24 months we will assess attrition rates and adverse events by participant characteristics and treatment condition; the durability of intervention effects on depression, obesity, and health-related quality of life; and simulation model-based projections of cost-effectiveness within trial and long term. & Via interviews with study care team, internal experts, PCPs, and medical and administrative leaders we will ask: How could the intervention be integrated into regular care and sustained after the study ended? 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How might these factors translate or not to real-world implementation? Were certain components more challenging to deliver than others? What modifications could be made to maximize realworld implementation?","text_display":"Via interviews with study care team, internal experts, PCPs, and medical and administrative leaders we will ask: What were the barriers to and enablers of delivering the intervention, and were they different across participating clinics? How might these factors translate or not to real-world implementation? Were certain components more challenging to deliver than others? What modifications could be made to maximize realworld implementation?","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9999973729108298},{"cnt":[[1187,1010],[1753,1010],[1753,1040],[1187,1040]],"region":{"top_left_x":1187,"top_left_y":1009,"width":566,"height":32},"line":65,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f861b162dabd43d8a9bb54a07909f810","type":"text","conversion_output":false,"parent_id":"0a4b0d6dec104acb865e6d4ddec57716","text":"Via interviews with study care team, internal experts,","text_display":"Via interviews with study care team, internal experts,","confidence":1,"confidence_rate":1},{"cnt":[[1187,1037],[1756,1037],[1756,1066],[1187,1066]],"region":{"top_left_x":1187,"top_left_y":1037,"width":570,"height":30},"line":66,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d026154118e646dd874c67b896a579bf","type":"text","conversion_output":false,"parent_id":"0a4b0d6dec104acb865e6d4ddec57716","text":"PCPs, and medical and administrative leaders we will","text_display":" PCPs, and medical and administrative leaders we will","confidence":1,"confidence_rate":1},{"cnt":[[1187,1065],[1787,1065],[1787,1097],[1187,1097]],"region":{"top_left_x":1187,"top_left_y":1064,"width":601,"height":34},"line":67,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5be21a36677747829f9cbc2d6ee09e1d","type":"text","conversion_output":false,"parent_id":"0a4b0d6dec104acb865e6d4ddec57716","text":"ask: What were the barriers to and enablers of delivering","text_display":" ask: What were the barriers to and enablers of delivering","confidence":0.99853515625,"confidence_rate":0.9999763564459245},{"cnt":[[1187,1092],[1687,1092],[1687,1125],[1187,1125]],"region":{"top_left_x":1187,"top_left_y":1092,"width":501,"height":33},"line":68,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"75df41f51fe54ed7a6e317cf7ec0141b","type":"text","conversion_output":false,"parent_id":"0a4b0d6dec104acb865e6d4ddec57716","text":"the intervention, and were they different across","text_display":" the intervention, and were they different across","confidence":1,"confidence_rate":1},{"cnt":[[1187,1120],[1797,1120],[1797,1152],[1187,1152]],"region":{"top_left_x":1187,"top_left_y":1119,"width":611,"height":34},"line":69,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2f3ea38add7d4f979171b54d4b7c1bf2","type":"text","conversion_output":false,"parent_id":"0a4b0d6dec104acb865e6d4ddec57716","text":"participating clinics? How might these factors translate or","text_display":" participating clinics? How might these factors translate or","confidence":1,"confidence_rate":1},{"cnt":[[1187,1150],[1693,1150],[1693,1180],[1187,1180]],"region":{"top_left_x":1187,"top_left_y":1150,"width":506,"height":30},"line":70,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"871a21c1f77c4fdabbd0347e663400ea","type":"text","conversion_output":false,"parent_id":"0a4b0d6dec104acb865e6d4ddec57716","text":"not to real-world implementation? Were certain","text_display":" not to real-world implementation? 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How often did they practice the intervention strategies? What were the perceived benefits? What problems did they encounter? How satisfied were they with program format, materials, and coach performance?","text_display":"Via interviews with a \\(10 \\%\\) random sample of intervention participants we will ask: How relevant and acceptable were the knowledge and skills gained? How often did they practice the intervention strategies? What were the perceived benefits? What problems did they encounter? 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the durability of intervention effects on depression, obesity, and health-related quality of life; and simulation model-based projections of cost-effectiveness within trial and long term.","text_display":"Using follow-up data through 24 months we will assess attrition rates and adverse events by participant characteristics and treatment condition; the durability of intervention effects on depression, obesity, and health-related quality of life; and simulation model-based projections of cost-effectiveness within trial and long term.","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99853515625,"confidence_rate":0.9999951046268714},{"cnt":[[703,1599],[1134,1599],[1134,1632],[703,1632]],"region":{"top_left_x":702,"top_left_y":1599,"width":432,"height":33},"line":95,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"85ddfe77155d4f2c94431531ff746ed8","type":"text","conversion_output":false,"parent_id":"e3940c08e8ce4a9da1aef6ccd1d9f6ae","text":"Using follow-up data through 24 months","text_display":"Using follow-up data through 24 months","confidence":1,"confidence_rate":1},{"cnt":[[703,1628],[1134,1628],[1134,1656],[703,1656]],"region":{"top_left_x":702,"top_left_y":1628,"width":432,"height":28},"line":96,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a6e760d98a5247b896c0205699e8c1d6","type":"text","conversion_output":false,"parent_id":"e3940c08e8ce4a9da1aef6ccd1d9f6ae","text":"we will assess attrition rates and adverse","text_display":" we will assess attrition rates and adverse","confidence":1,"confidence_rate":1},{"cnt":[[703,1656],[1129,1656],[1129,1688],[703,1688]],"region":{"top_left_x":702,"top_left_y":1655,"width":427,"height":34},"line":97,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8e250616de3e4c748004546a87333fc5","type":"text","conversion_output":false,"parent_id":"e3940c08e8ce4a9da1aef6ccd1d9f6ae","text":"events by participant characteristics and","text_display":" events by participant characteristics and","confidence":1,"confidence_rate":1},{"cnt":[[703,1683],[1100,1683],[1100,1716],[703,1716]],"region":{"top_left_x":702,"top_left_y":1683,"width":398,"height":33},"line":98,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"68804fdf62ad4bd38c2bba2b139e8f53","type":"text","conversion_output":false,"parent_id":"e3940c08e8ce4a9da1aef6ccd1d9f6ae","text":"treatment condition; 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What resources, policies, and care process redesigns would be needed to maximize sustainability?","text_display":"Via interviews with study care team, internal experts, PCPs, and medical and administrative leaders we will ask: How could the intervention be integrated into regular care and sustained after the study ended? What resources, policies, and care process redesigns would be needed to maximize sustainability?","cell_row":6,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.998046875,"confidence_rate":0.9999948279635449},{"cnt":[[1187,1597],[1753,1597],[1753,1633],[1187,1633]],"region":{"top_left_x":1187,"top_left_y":1597,"width":566,"height":37},"line":105,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c6acc186834345dd9e04d415824b6e26","type":"text","conversion_output":false,"parent_id":"8a0ff7131bdd4e86b44609aff9b7b8f5","text":"Via interviews with study care team, internal experts,","text_display":"Via interviews with study care team, internal experts,","confidence":1,"confidence_rate":1},{"cnt":[[1187,1628],[1756,1628],[1756,1658],[1187,1658]],"region":{"top_left_x":1187,"top_left_y":1628,"width":570,"height":30},"line":106,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"75a1e2c6a5c145a8bc70c5ddf5e06a45","type":"text","conversion_output":false,"parent_id":"8a0ff7131bdd4e86b44609aff9b7b8f5","text":"PCPs, and medical and administrative leaders we will","text_display":" PCPs, and medical and administrative leaders we will","confidence":1,"confidence_rate":1},{"cnt":[[1187,1656],[1799,1656],[1799,1688],[1187,1688]],"region":{"top_left_x":1187,"top_left_y":1655,"width":613,"height":34},"line":107,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d52cf43e2e3043f0a180ebff69e1a640","type":"text","conversion_output":false,"parent_id":"8a0ff7131bdd4e86b44609aff9b7b8f5","text":"ask: How could the intervention be integrated into regular","text_display":" ask: How could the intervention be integrated into regular","confidence":0.998046875,"confidence_rate":0.9999689681825158},{"cnt":[[1187,1683],[1797,1683],[1797,1716],[1187,1716]],"region":{"top_left_x":1187,"top_left_y":1683,"width":611,"height":33},"line":108,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d4986b85a2cb4841a18a8291031f580f","type":"text","conversion_output":false,"parent_id":"8a0ff7131bdd4e86b44609aff9b7b8f5","text":"care and sustained after the study ended? What resources,","text_display":" care and sustained after the study ended? 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Author manuscript; available in PMC 2016 July 01.","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}
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