diff --git "a/documents/10.1001_jama.2019.0234/sap.lines.json" "b/documents/10.1001_jama.2019.0234/sap.lines.json"
new file mode 100644--- /dev/null
+++ "b/documents/10.1001_jama.2019.0234/sap.lines.json"
@@ -0,0 +1 @@
+{"pages":[{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-01","page":1,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cff543ae5154fcb8cb82e7b87b8c2d9","type":"page_info","conversion_output":false,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75cde4bafd9c45638ec03e534c36de4f","type":"page_info","conversion_output":false,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bc7e1cfe7bc47719a721e334d881c39","type":"page_info","conversion_output":false,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[726,292],[1399,292],[1399,350],[726,350]],"region":{"top_left_x":726,"top_left_y":292,"width":673,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f22037e80837487fa2908b504f679fa1","type":"section_header","conversion_output":false,"children_ids":["3a9faa8932c740ceb7d9f3b3bf28b58b"],"text":"","text_display":""},{"cnt":[[730,296],[1394,296],[1394,342],[730,342]],"region":{"top_left_x":730,"top_left_y":296,"width":665,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a9faa8932c740ceb7d9f3b3bf28b58b","type":"text","conversion_output":true,"parent_id":"f22037e80837487fa2908b504f679fa1","text":"SUPPLEMENTARY APPENDIXES","text_display":"\\section*{SUPPLEMENTARY APPENDIXES}","confidence":1,"confidence_rate":1},{"cnt":[[241,432],[408,432],[408,479],[241,479]],"region":{"top_left_x":240,"top_left_y":431,"width":169,"height":49},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb4da48611404ce89e38b5d31715a7b9","type":"section_header","conversion_output":false,"children_ids":["4eab01602a7d43d1a5a80f2d52501216"],"text":"","text_display":""},{"cnt":[[245,438],[406,438],[406,471],[245,471]],"region":{"top_left_x":244,"top_left_y":438,"width":163,"height":33},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4eab01602a7d43d1a5a80f2d52501216","type":"text","conversion_output":true,"parent_id":"fb4da48611404ce89e38b5d31715a7b9","text":"Contents","text_display":"\n\n\\section*{Contents}","confidence":1,"confidence_rate":1},{"cnt":[[245,481],[1412,481],[1412,518],[245,518]],"region":{"top_left_x":244,"top_left_y":481,"width":1168,"height":37},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"962664f73bce48128bcdf78fbd74c5ca","type":"text","conversion_output":true,"text":"eAPPENDIX 1. STUDY PROTOCOL AND STATISTICAL ANALYSIS PLAN","text_display":"\neAPPENDIX 1. STUDY PROTOCOL AND STATISTICAL ANALYSIS PLAN","confidence":0.99560546875,"confidence_rate":0.9999289667877371},{"cnt":[[245,546],[1680,546],[1680,582],[245,582]],"region":{"top_left_x":244,"top_left_y":545,"width":1437,"height":38},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45bce2ce9efc4f24acc33e5d06f330b8","type":"text","conversion_output":true,"text":"eAPPENDIX 2. FAST TRACK PROTOCOL AND INTRAVENOUS DRUG ADMINISTRATION","text_display":"\neAPPENDIX 2. FAST TRACK PROTOCOL AND INTRAVENOUS DRUG ADMINISTRATION","confidence":1,"confidence_rate":1},{"cnt":[[245,591],[466,591],[466,627],[245,627]],"region":{"top_left_x":244,"top_left_y":590,"width":223,"height":38},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58ef0b6663504ac5a85e9400f52a0c9e","type":"text","conversion_output":true,"text":"GUIDELINES","text_display":" GUIDELINES","confidence":1,"confidence_rate":1},{"cnt":[[245,653],[492,653],[492,690],[245,690]],"region":{"top_left_x":244,"top_left_y":653,"width":248,"height":37},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83621db9e70e42d2b1e80a05cdbc44eb","type":"text","conversion_output":true,"text":"REFERENCES","text_display":"\n\nREFERENCES","confidence":1,"confidence_rate":1},{"cnt":[[245,885],[1794,885],[1794,930],[245,930]],"region":{"top_left_x":244,"top_left_y":885,"width":1550,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90987736bb07458c9c56fe0dadc933d1","type":"text","conversion_output":true,"text":"This supplementary material has been provided by the authors to give readers additional information","text_display":"\n\nThis supplementary material has been provided by the authors to give readers additional information","confidence":1,"confidence_rate":1},{"cnt":[[245,932],[509,932],[509,969],[245,969]],"region":{"top_left_x":244,"top_left_y":932,"width":266,"height":37},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0747137ff27c4d7cad6b54cc65aa0d66","type":"text","conversion_output":true,"text":"about their work.","text_display":" about their work.","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-02","page":2,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79f6abc2879d4751a474cfd3faf906fa","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"108c0250a9f340a1bb45b8d22d9fabda","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,249],[245,249]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c82ddfe906e498589593dc20a67a7f4","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1433,249],[1433,290],[245,290]],"region":{"top_left_x":244,"top_left_y":249,"width":1190,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a35e00f06267444e8029ea8f9cc9aba0","type":"text","conversion_output":true,"text":"eAPPENDIX 1. STUDY PROTOCOL AND STATISTICAL ANALYSIS PLAN","text_display":"\neAPPENDIX 1. STUDY PROTOCOL AND STATISTICAL ANALYSIS PLAN","confidence":0.99755859375,"confidence_rate":0.9999605751103785},{"cnt":[[363,372],[1613,372],[1613,1145],[363,1145]],"region":{"top_left_x":363,"top_left_y":371,"width":1251,"height":775},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3366e2998744ab59a136e6bcbbcf23b","type":"table","conversion_output":true,"children_ids":["cf3613c4bb9a480693d4069256e426c4","c6a1b082639645be8ed48e7e4b083384","4d2db3739e1d4dfc9929f1b9d1aeb8ea","9098883cc9e0443b8ef35b6e99ddd8f8","dec1bce9dae848d18cbc10502d2aae37","1ec5e89cf05443768ac34b7426f94826","0c49428fcb374c3eaa3f6af57ec2ac31","9ec70ad6cd994ac48f157d8cf5b873d1","a2fb7dc782aa400c98dc96a0de9ddb38","a22284579b8142a5a8a966866ffdcb89","ab01230fe890488a80bb84fb44630cad","af52af8b563448d09b92e461189f7c4b","480fef1c069a4e92a6ea30aa1f203627","f8d01e8f50b54cdca63afe8b35625ee0","bf0467e0ac3f459bac7e41038e0e624e","784163bd0ac6457bb66d04ef1687fd5e","e38f0abbff6344c5b4f2ebd85ede67a1","09f2175a3686487c8c2a77b7ec116729","394177aad1de4af0abfc714cd61269d0","188023f21eea46dcaf6f82400cc2528b","f680b0785c414237883f7e310232841b","b8b0d1bd1cf7467fab607a03d24b7df5","1e789b29d2cb47e299dcff9c20b2379c","141f4699a2f9465986c96e669e3d74ec","5d1366b329f14e6fa600b487a7004419"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline ![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=194\\&width=159\\&top_left_y=375\\&top_left_x=367) & Beth Israel Deaconess Medical Center & \\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=103\\&width=88\\&top_left_y=435\\&top_left_x=1181) \\\\\nHARVARD MEDICAL TEACHING HOSPITA\n\\end{tabular} \\\\\n\\hline Principal Investigator: & & Balachundhar Subramaniam, MD, MPH \\\\\n\\hline Study Sponsor: & & Mallinckrodt Pharmaceuticals \\\\\n\\hline Study Coordinating Center: & & Beth Israel Deaconess Medical Center \\\\\n\\hline Original Protocol Version Date: & 01/29/2015 & \\\\\n\\hline IRB Protocol Number: & 2014P000413 & \\\\\n\\hline Clinicaltrials.gov NCT: & NCT02546765 & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline ![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=194\\&width=159\\&top_left_y=375\\&top_left_x=367) & Beth Israel Deaconess Medical Center & \\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=103\\&width=88\\&top_left_y=435\\&top_left_x=1181) \\\\\nHARVARD MEDICAL TEACHING HOSPITA\n\\end{tabular} \\\\\n\\hline Principal Investigator: & & Balachundhar Subramaniam, MD, MPH \\\\\n\\hline Study Sponsor: & & Mallinckrodt Pharmaceuticals \\\\\n\\hline Study Coordinating Center: & & Beth Israel Deaconess Medical Center \\\\\n\\hline Original Protocol Version Date: & 01/29/2015 & \\\\\n\\hline IRB Protocol Number: & 2014P000413 & \\\\\n\\hline Clinicaltrials.gov NCT: & NCT02546765 & \\\\\n\\hline\n\\end{tabular}","confidence":0,"confidence_rate":0},{"cnt":[[363,371],[896,371],[896,1146],[363,1146]],"region":{"top_left_x":363,"top_left_y":371,"width":533,"height":776},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf3613c4bb9a480693d4069256e426c4","type":"table_column","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[991,371],[1136,371],[1136,1146],[991,1146]],"region":{"top_left_x":990,"top_left_y":371,"width":147,"height":776},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6a1b082639645be8ed48e7e4b083384","type":"table_column","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[1171,371],[1615,371],[1615,1146],[1171,1146]],"region":{"top_left_x":1170,"top_left_y":371,"width":445,"height":776},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d2db3739e1d4dfc9929f1b9d1aeb8ea","type":"table_column","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,371],[1615,371],[1615,572],[363,572]],"region":{"top_left_x":363,"top_left_y":371,"width":1252,"height":202},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9098883cc9e0443b8ef35b6e99ddd8f8","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,687],[1612,687],[1612,737],[363,737]],"region":{"top_left_x":363,"top_left_y":687,"width":1250,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dec1bce9dae848d18cbc10502d2aae37","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,765],[1615,765],[1615,817],[363,817]],"region":{"top_left_x":363,"top_left_y":765,"width":1252,"height":53},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ec5e89cf05443768ac34b7426f94826","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,850],[1612,850],[1612,902],[363,902]],"region":{"top_left_x":363,"top_left_y":849,"width":1250,"height":53},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c49428fcb374c3eaa3f6af57ec2ac31","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,930],[1612,930],[1612,984],[363,984]],"region":{"top_left_x":363,"top_left_y":929,"width":1250,"height":55},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ec70ad6cd994ac48f157d8cf5b873d1","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,1014],[1615,1014],[1615,1060],[363,1060]],"region":{"top_left_x":363,"top_left_y":1014,"width":1252,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2fb7dc782aa400c98dc96a0de9ddb38","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,1094],[1615,1094],[1615,1144],[363,1144]],"region":{"top_left_x":363,"top_left_y":1094,"width":1252,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a22284579b8142a5a8a966866ffdcb89","type":"table_row","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"","text_display":""},{"cnt":[[363,568],[365,369],[528,371],[525,570]],"region":{"top_left_x":362,"top_left_y":369,"width":166,"height":201},"line":16,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"ab01230fe890488a80bb84fb44630cad","type":"complex_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","children_ids":["ccca9862334041f6979a5b9921ca3825"],"text":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=194\\&width=159\\&top_left_y=375\\&top_left_x=367)","text_display":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=194\\&width=159\\&top_left_y=375\\&top_left_x=367)","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0,"confidence_rate":0},{"cnt":[[367,375],[525,375],[525,568],[367,568]],"region":{"top_left_x":367,"top_left_y":375,"width":159,"height":194},"line":17,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"ccca9862334041f6979a5b9921ca3825","type":"diagram","conversion_output":false,"parent_id":"ab01230fe890488a80bb84fb44630cad","text":"","text_display":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=194\\&width=159\\&top_left_y=375\\&top_left_x=367)"},{"cnt":[[541,427],[1123,427],[1123,546],[541,546]],"region":{"top_left_x":540,"top_left_y":427,"width":584,"height":120},"line":18,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"af52af8b563448d09b92e461189f7c4b","type":"complex_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","children_ids":["151f57b608444289a6e0111b8383f2a7","50553d3c38514d7193adbe26d906481b"],"text":"Beth Israel Deaconess Medical Center","text_display":"Beth Israel Deaconess Medical Center","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[549,432],[1121,432],[1121,484],[549,484]],"region":{"top_left_x":549,"top_left_y":431,"width":572,"height":53},"line":19,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"151f57b608444289a6e0111b8383f2a7","type":"text","conversion_output":false,"parent_id":"af52af8b563448d09b92e461189f7c4b","text":"Beth Israel Deaconess","text_display":"Beth Israel Deaconess","confidence":1,"confidence_rate":1},{"cnt":[[549,488],[959,488],[959,540],[549,540]],"region":{"top_left_x":549,"top_left_y":487,"width":410,"height":53},"line":20,"column":0,"font_size":56,"is_printed":true,"is_handwritten":false,"id":"50553d3c38514d7193adbe26d906481b","type":"text","conversion_output":false,"parent_id":"af52af8b563448d09b92e461189f7c4b","text":"Medical Center","text_display":" Medical Center","confidence":1,"confidence_rate":1},{"cnt":[[1182,432],[1615,432],[1615,540],[1182,540]],"region":{"top_left_x":1181,"top_left_y":431,"width":434,"height":109},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"480fef1c069a4e92a6ea30aa1f203627","type":"complex_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","children_ids":["332d5fb8d7654f65910bf4c79c0ac3d1","0c92b4fe54b641ffbed6683ee5796e72","b8261131696b4c608f006d93977b871c"],"text":"\\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=103\\&width=88\\&top_left_y=435\\&top_left_x=1181) \\\\\nHARVARD MEDICAL TEACHING HOSPITA\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=103\\&width=88\\&top_left_y=435\\&top_left_x=1181) \\\\\nHARVARD MEDICAL TEACHING HOSPITA\n\\end{tabular}","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.994140625,"confidence_rate":0.999860090538504},{"cnt":[[1182,436],[1268,436],[1268,538],[1182,538]],"region":{"top_left_x":1181,"top_left_y":435,"width":88,"height":103},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"332d5fb8d7654f65910bf4c79c0ac3d1","type":"diagram","conversion_output":false,"parent_id":"480fef1c069a4e92a6ea30aa1f203627","text":"","text_display":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-02.jpg?height=103\\&width=88\\&top_left_y=435\\&top_left_x=1181)","subtype":"logo"},{"cnt":[[1290,449],[1612,449],[1612,481],[1290,481]],"region":{"top_left_x":1289,"top_left_y":448,"width":324,"height":34},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c92b4fe54b641ffbed6683ee5796e72","type":"text","conversion_output":false,"parent_id":"480fef1c069a4e92a6ea30aa1f203627","text":"HARVARD MEDICAL","text_display":"\nHARVARD MEDICAL","confidence":1,"confidence_rate":1},{"cnt":[[1285,488],[1612,488],[1612,520],[1285,520]],"region":{"top_left_x":1285,"top_left_y":487,"width":328,"height":34},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8261131696b4c608f006d93977b871c","type":"text","conversion_output":false,"parent_id":"480fef1c069a4e92a6ea30aa1f203627","text":"TEACHING HOSPITA","text_display":" TEACHING HOSPITA","confidence":0.994140625,"confidence_rate":0.9997202006516653},{"cnt":[[374,691],[740,691],[740,733],[374,733]],"region":{"top_left_x":373,"top_left_y":691,"width":367,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8d01e8f50b54cdca63afe8b35625ee0","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Principal Investigator:","text_display":"Principal Investigator:","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1000,691],[1612,691],[1612,728],[1000,728]],"region":{"top_left_x":999,"top_left_y":691,"width":614,"height":38},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf0467e0ac3f459bac7e41038e0e624e","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Balachundhar Subramaniam, MD, MPH","text_display":"Balachundhar Subramaniam, MD, MPH","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[374,774],[634,774],[634,815],[374,815]],"region":{"top_left_x":373,"top_left_y":773,"width":261,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"784163bd0ac6457bb66d04ef1687fd5e","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Study Sponsor:","text_display":"Study Sponsor:","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1000,774],[1452,774],[1452,808],[1000,808]],"region":{"top_left_x":999,"top_left_y":773,"width":454,"height":36},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e38f0abbff6344c5b4f2ebd85ede67a1","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Mallinckrodt Pharmaceuticals","text_display":"Mallinckrodt Pharmaceuticals","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999852000944255},{"cnt":[[374,856],[829,856],[829,897],[374,897]],"region":{"top_left_x":373,"top_left_y":856,"width":456,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09f2175a3686487c8c2a77b7ec116729","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Study Coordinating Center:","text_display":"Study Coordinating Center:","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999684830886739},{"cnt":[[1000,856],[1595,856],[1595,889],[1000,889]],"region":{"top_left_x":999,"top_left_y":856,"width":597,"height":33},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"394177aad1de4af0abfc714cd61269d0","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Beth Israel Deaconess Medical Center","text_display":"Beth Israel Deaconess Medical Center","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[374,938],[889,938],[889,980],[374,980]],"region":{"top_left_x":373,"top_left_y":938,"width":517,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"188023f21eea46dcaf6f82400cc2528b","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Original Protocol Version Date:","text_display":"Original Protocol Version Date:","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1000,938],[1175,938],[1175,971],[1000,971]],"region":{"top_left_x":999,"top_left_y":938,"width":177,"height":33},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f680b0785c414237883f7e310232841b","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"01/29/2015","text_display":"01/29/2015","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[374,1021],[738,1021],[738,1053],[374,1053]],"region":{"top_left_x":373,"top_left_y":1020,"width":365,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8b0d1bd1cf7467fab607a03d24b7df5","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"IRB Protocol Number:","text_display":"IRB Protocol Number:","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1000,1021],[1218,1021],[1218,1053],[1000,1053]],"region":{"top_left_x":999,"top_left_y":1020,"width":220,"height":34},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e789b29d2cb47e299dcff9c20b2379c","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"2014P000413","text_display":"2014P000413","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[374,1099],[746,1099],[746,1140],[374,1140]],"region":{"top_left_x":373,"top_left_y":1098,"width":374,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"141f4699a2f9465986c96e669e3d74ec","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"Clinicaltrials.gov NCT:","text_display":"Clinicaltrials.gov NCT:","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9921910762786865,"confidence_rate":0.9997200544410312},{"cnt":[[1000,1101],[1227,1101],[1227,1135],[1000,1135]],"region":{"top_left_x":999,"top_left_y":1100,"width":229,"height":36},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d1366b329f14e6fa600b487a7004419","type":"simple_cell","conversion_output":false,"parent_id":"f3366e2998744ab59a136e6bcbbcf23b","text":"NCT02546765","text_display":"NCT02546765","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[894,1259],[1233,1259],[1233,1308],[894,1308]],"region":{"top_left_x":893,"top_left_y":1258,"width":341,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd6291bb2ede4ab8844604b5a9ad77f2","type":"section_header","conversion_output":false,"children_ids":["f77185ddafc54b70a50f77d336257e72"],"text":"","text_display":""},{"cnt":[[898,1261],[1229,1261],[1229,1302],[898,1302]],"region":{"top_left_x":898,"top_left_y":1261,"width":331,"height":41},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f77185ddafc54b70a50f77d336257e72","type":"text","conversion_output":true,"parent_id":"cd6291bb2ede4ab8844604b5a9ad77f2","text":"STUDY PROTOCOL","text_display":"\n\n\\section*{STUDY PROTOCOL}","confidence":1,"confidence_rate":1},{"cnt":[[243,1336],[397,1336],[397,1386],[243,1386]],"region":{"top_left_x":242,"top_left_y":1336,"width":156,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfe811270f87440faf2781ac28fd1ce8","type":"section_header","conversion_output":false,"children_ids":["4652fbd650854ed99a879546b2b157e3"],"text":"","text_display":""},{"cnt":[[247,1341],[393,1341],[393,1381],[247,1381]],"region":{"top_left_x":247,"top_left_y":1340,"width":147,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4652fbd650854ed99a879546b2b157e3","type":"text","conversion_output":true,"parent_id":"bfe811270f87440faf2781ac28fd1ce8","text":"Purpose","text_display":"\n\n\\section*{Purpose}","confidence":1,"confidence_rate":1},{"cnt":[[247,1384],[1880,1384],[1880,1429],[247,1429]],"region":{"top_left_x":247,"top_left_y":1383,"width":1633,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3cc1e71cb994d7fb2acc40879a081f3","type":"text","conversion_output":true,"text":"The goal of this randomized clinical trial is to evaluate the effect of intravenous (IV) acetaminophen vs","text_display":"\n\nThe goal of this randomized clinical trial is to evaluate the effect of intravenous (IV) acetaminophen vs","confidence":1,"confidence_rate":1},{"cnt":[[247,1431],[1878,1431],[1878,1474],[247,1474]],"region":{"top_left_x":247,"top_left_y":1430,"width":1631,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"178ed9fbb93047f5aefbaaccfe0744f4","type":"text","conversion_output":true,"text":"placebo, combined with IV propofol vs dexmedetomidine, for postoperative sedation and analgesia","text_display":" placebo, combined with IV propofol vs dexmedetomidine, for postoperative sedation and analgesia","confidence":1,"confidence_rate":1},{"cnt":[[247,1474],[1880,1474],[1880,1519],[247,1519]],"region":{"top_left_x":247,"top_left_y":1473,"width":1633,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9733f8fbf6d47d0942ea0651022045f","type":"text","conversion_output":true,"text":"respectively, in adult patients 60 years or older undergoing coronary artery bypass grafting (CABG) or","text_display":" respectively, in adult patients 60 years or older undergoing coronary artery bypass grafting (CABG) or","confidence":1,"confidence_rate":1},{"cnt":[[247,1521],[1880,1521],[1880,1566],[247,1566]],"region":{"top_left_x":247,"top_left_y":1521,"width":1633,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1dfbea9bbcc465ea1eb0aa3727c63f2","type":"text","conversion_output":true,"text":"combined CABG/valve surgeries to assess the incidence of postoperative delirium with the Confusion","text_display":" combined CABG/valve surgeries to assess the incidence of postoperative delirium with the Confusion","confidence":1,"confidence_rate":1},{"cnt":[[245,1566],[1880,1566],[1880,1611],[245,1611]],"region":{"top_left_x":244,"top_left_y":1566,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6be206922614410395f12ddb7059ad91","type":"text","conversion_output":true,"text":"Assessment Method (CAM or CAM-ICU). It is possible that there may be a benefit to those enrolled in the","text_display":" Assessment Method (CAM or CAM-ICU). It is possible that there may be a benefit to those enrolled in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1880,1611],[1880,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1611,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7059e3d855ee411694ef5653613320a1","type":"text","conversion_output":true,"text":"dexmedetomidine and acetaminophen group, as their incidence of delirium could possibly be reduced,","text_display":" dexmedetomidine and acetaminophen group, as their incidence of delirium could possibly be reduced,","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[793,1659],[793,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":549,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68e72056ad344ab688c358fb2583582c","type":"text","conversion_output":true,"text":"however we cannot guarantee this.","text_display":" however we cannot guarantee this.","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[1880,1740],[1880,1785],[245,1785]],"region":{"top_left_x":244,"top_left_y":1740,"width":1636,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b8a079bef9441f7ada8fc5bd2b17de5","type":"text","conversion_output":true,"text":"Additionally, this study will assess postoperative cognition following cardiac surgery through 1 -year using a","text_display":"\n\nAdditionally, this study will assess postoperative cognition following cardiac surgery through 1 -year using a","confidence":0.8829259872436523,"confidence_rate":0.9989453539749625},{"cnt":[[245,1783],[1880,1783],[1880,1830],[245,1830]],"region":{"top_left_x":244,"top_left_y":1783,"width":1636,"height":48},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"242406a118134287893009fedfad34a0","type":"text","conversion_output":true,"text":"cognitive assessment scale and compare postoperative analgesic requirements in patients with and without","text_display":" cognitive assessment scale and compare postoperative analgesic requirements in patients with and without","confidence":1,"confidence_rate":1},{"cnt":[[245,1830],[544,1830],[544,1876],[245,1876]],"region":{"top_left_x":244,"top_left_y":1830,"width":300,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dfb5941d4df4c4a9d596e2f44eab03d","type":"text","conversion_output":true,"text":"IV acetaminophen.","text_display":" IV acetaminophen.","confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be8855c1bdce46e9b2dd6260d3a1c386","type":"page_info","conversion_output":false,"text":"2","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-03","page":3,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29dfd086f3854b78bbce409c8ff54833","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1762,168],[1762,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1518,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ceedeaa6b564978bc0009e1d417d014","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d0d1aa44ab2450482dbdb9bc22544dc","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[243,247],[522,247],[522,299],[243,299]],"region":{"top_left_x":242,"top_left_y":247,"width":281,"height":52},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1754cf547fa14f08bbc3bc236cf51633","type":"section_header","conversion_output":false,"children_ids":["59ec3201bea54672b53df1afd99d6415"],"text":"","text_display":""},{"cnt":[[247,254],[518,254],[518,294],[247,294]],"region":{"top_left_x":247,"top_left_y":253,"width":271,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59ec3201bea54672b53df1afd99d6415","type":"text","conversion_output":true,"parent_id":"1754cf547fa14f08bbc3bc236cf51633","text":"Study Summary","text_display":"\n\n\\section*{Study Summary}","confidence":1,"confidence_rate":1},{"cnt":[[243,382],[1886,382],[1886,2075],[243,2075]],"region":{"top_left_x":242,"top_left_y":382,"width":1645,"height":1694},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3a4937954624fdfb027bb89db43ff73","type":"table","conversion_output":true,"children_ids":["293e60becbce442dbb0eb93f88a139fd","762b1908a71f47c8bd23b23bd420cb6b","7b3ce9aeaddc4604b8b5989f2a6a592a","e01317e9af9a40faa9e447ce0682dee2","ad16f7d4e67042d6b2a65cdd9f9cd03f","c074af81163d4c26befcef80535f55b4","e770997fe1cd4d52ac4c973be8fd6898","aa9ba80dc8474ac29c3619485fb6303b","dc8c95a0445d41ff8eeb9dbda0074fef","76bdf4dda9364101bd6d3b6b7b0c4367","fe9e5a1636f14e3fa45409f5eef9ebdc","43aeb39b48924ac083b100c18677c5d7","54e9137d4e454526b211847b29136769","1dd38b02fb164a5db92a62eb39fd8c39","36062c786213421aa613cef8360388a3","e3d76e9fcd2a4351b21893de3add39f5","1cbda80448e842fab760e5843a6ce3b1","2cf4888f3c3641279022152276753c06","4490b439cc44407593c11135132fff8d","5d04141aaa664185bfffd93bf26ca1dc","3795efa074cf4928a83b6cc67432a6ee","b92a88c77b9a413eb5286334267f35fa","0933e1268a164a4ca790b22358f2fe8b","6401b2b1801844d3a1959ed547aff5a7","ba8b260ab2944306afa29221bc528d84","729592e2c76845a7866e7da46569187a","81a44a5829b344679130117df849baec","4e689b08caf04f62843f61c0623e3b4c","3ef7ba7f93ef4086b1de2c6ceb11eb96"],"text":"\\begin{tabular}{|l|l|}\n\\hline Title & Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or Dexmedetomidine, on Postoperative InHospital Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial \\\\\n\\hline Objective & To evaluate the effect of postoperative IV acetaminophen (paracetamol) vs placebo, combined with IV propofol vs dexmedetomidine, on postoperative delirium among older patients undergoing cardiac surgery \\\\\n\\hline Inclusion Criteria & Patients 60 years or older undergoing CABG with or without aortic and/or mitral valve replacement requiring cardiopulmonary bypass \\\\\n\\hline Exclusion Criteria & Patients with preoperative left ventricular ejection fraction (LVEF) <30\\%, pre-existing cognitive impairment, Alzheimer's disease, Parkinson's disease, medications for cognitive decline, history of recent seizures, serum creatinine \\(>2 mg / dL\\), liver dysfunction, recent history of alcohol abuse, English language limitations, hypersensitivity to study medications, and undergoing emergent surgery \\\\\n\\hline Study Design & Single center, randomized, triple blind, placebo controlled, factorial design clinical trial \\\\\n\\hline & Patients were randomized to one of four factorial groups which included randomization to receive postoperative analgesia with intravenous acetaminophen or placebo every 6 hours for 48 hours. In addition, patients were randomized to receive postoperative sedation starting at chest closure and continued for up to 6 hours postoperatively or until extubation with intravenous dexmedetomidine or propofol. \\\\\n\\hline & The incidence of postoperative in-hospital delirium was assessed daily using the CAM or CAM-ICU during the patient's hospitalization. In addition, follow up assessments were conducted at one month and one year. \\\\\n\\hline Study Discontinuation & Patient request or any serious adverse event thought to be related to study procedures \\\\\n\\hline Key Roles & Principal Investigator: Balachundhar Subramaniam, MD MPH \\\\\n\\hline & Institution: Beth Israel Deaconess Medical Center, Boston MA \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Title & Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or Dexmedetomidine, on Postoperative InHospital Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial \\\\\n\\hline Objective & To evaluate the effect of postoperative IV acetaminophen (paracetamol) vs placebo, combined with IV propofol vs dexmedetomidine, on postoperative delirium among older patients undergoing cardiac surgery \\\\\n\\hline Inclusion Criteria & Patients 60 years or older undergoing CABG with or without aortic and/or mitral valve replacement requiring cardiopulmonary bypass \\\\\n\\hline Exclusion Criteria & Patients with preoperative left ventricular ejection fraction (LVEF) <30\\%, pre-existing cognitive impairment, Alzheimer's disease, Parkinson's disease, medications for cognitive decline, history of recent seizures, serum creatinine \\(>2 mg / dL\\), liver dysfunction, recent history of alcohol abuse, English language limitations, hypersensitivity to study medications, and undergoing emergent surgery \\\\\n\\hline Study Design & Single center, randomized, triple blind, placebo controlled, factorial design clinical trial \\\\\n\\hline & Patients were randomized to one of four factorial groups which included randomization to receive postoperative analgesia with intravenous acetaminophen or placebo every 6 hours for 48 hours. In addition, patients were randomized to receive postoperative sedation starting at chest closure and continued for up to 6 hours postoperatively or until extubation with intravenous dexmedetomidine or propofol. \\\\\n\\hline & The incidence of postoperative in-hospital delirium was assessed daily using the CAM or CAM-ICU during the patient's hospitalization. In addition, follow up assessments were conducted at one month and one year. \\\\\n\\hline Study Discontinuation & Patient request or any serious adverse event thought to be related to study procedures \\\\\n\\hline Key Roles & Principal Investigator: Balachundhar Subramaniam, MD MPH \\\\\n\\hline & Institution: Beth Israel Deaconess Medical Center, Boston MA \\\\\n\\hline\n\\end{tabular}","confidence":0.7166220190748618,"confidence_rate":0.9999586498066139},{"cnt":[[242,382],[625,382],[625,2075],[242,2075]],"region":{"top_left_x":242,"top_left_y":382,"width":384,"height":1694},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"293e60becbce442dbb0eb93f88a139fd","type":"table_column","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[738,382],[1883,382],[1883,2075],[738,2075]],"region":{"top_left_x":737,"top_left_y":382,"width":1147,"height":1694},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"762b1908a71f47c8bd23b23bd420cb6b","type":"table_column","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,382],[1890,382],[1890,568],[242,568]],"region":{"top_left_x":242,"top_left_y":382,"width":1648,"height":187},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b3ce9aeaddc4604b8b5989f2a6a592a","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,599],[1890,599],[1890,744],[242,744]],"region":{"top_left_x":242,"top_left_y":598,"width":1648,"height":146},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e01317e9af9a40faa9e447ce0682dee2","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,772],[1890,772],[1890,869],[242,869]],"region":{"top_left_x":242,"top_left_y":771,"width":1648,"height":99},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad16f7d4e67042d6b2a65cdd9f9cd03f","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,897],[1890,897],[1890,1185],[242,1185]],"region":{"top_left_x":242,"top_left_y":897,"width":1648,"height":289},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c074af81163d4c26befcef80535f55b4","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,1209],[1890,1209],[1890,1307],[242,1307]],"region":{"top_left_x":242,"top_left_y":1209,"width":1648,"height":98},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e770997fe1cd4d52ac4c973be8fd6898","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,1337],[1890,1337],[1890,1623],[242,1623]],"region":{"top_left_x":242,"top_left_y":1336,"width":1648,"height":287},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa9ba80dc8474ac29c3619485fb6303b","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,1649],[1890,1649],[1890,1794],[242,1794]],"region":{"top_left_x":242,"top_left_y":1648,"width":1648,"height":146},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc8c95a0445d41ff8eeb9dbda0074fef","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,1820],[1890,1820],[1890,1917],[242,1917]],"region":{"top_left_x":242,"top_left_y":1819,"width":1648,"height":99},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76bdf4dda9364101bd6d3b6b7b0c4367","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,1948],[1890,1948],[1890,2000],[242,2000]],"region":{"top_left_x":242,"top_left_y":1947,"width":1648,"height":53},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe9e5a1636f14e3fa45409f5eef9ebdc","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[242,2030],[1890,2030],[1890,2073],[242,2073]],"region":{"top_left_x":242,"top_left_y":2029,"width":1648,"height":45},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43aeb39b48924ac083b100c18677c5d7","type":"table_row","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"","text_display":""},{"cnt":[[246,386],[324,386],[324,425],[246,425]],"region":{"top_left_x":246,"top_left_y":386,"width":79,"height":40},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54e9137d4e454526b211847b29136769","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Title","text_display":"Title","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[744,384],[1883,384],[1883,564],[744,564]],"region":{"top_left_x":744,"top_left_y":384,"width":1140,"height":180},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dd38b02fb164a5db92a62eb39fd8c39","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["10df9dd89dc7428495ee4afef81f1af5","0893aa831a4c4d939848e3e8a7c85dfb","a54b768b8c70460fa59b82b0aa1666fc","e6cafe05e0e04e429995d6e2ca9316da"],"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or Dexmedetomidine, on Postoperative InHospital Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial","text_display":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or Dexmedetomidine, on Postoperative InHospital Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,386],[1877,386],[1877,427],[749,427]],"region":{"top_left_x":748,"top_left_y":386,"width":1129,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10df9dd89dc7428495ee4afef81f1af5","type":"text","conversion_output":false,"parent_id":"1dd38b02fb164a5db92a62eb39fd8c39","text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo,","text_display":"Effect of Postoperative Intravenous Acetaminophen versus Placebo,","confidence":1,"confidence_rate":1},{"cnt":[[749,430],[1877,430],[1877,473],[749,473]],"region":{"top_left_x":748,"top_left_y":429,"width":1129,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0893aa831a4c4d939848e3e8a7c85dfb","type":"text","conversion_output":false,"parent_id":"1dd38b02fb164a5db92a62eb39fd8c39","text":"Combined with Propofol or Dexmedetomidine, on Postoperative In-","text_display":" Combined with Propofol or Dexmedetomidine, on Postoperative In","confidence":1,"confidence_rate":1},{"cnt":[[749,477],[1877,477],[1877,518],[749,518]],"region":{"top_left_x":748,"top_left_y":477,"width":1129,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a54b768b8c70460fa59b82b0aa1666fc","type":"text","conversion_output":false,"parent_id":"1dd38b02fb164a5db92a62eb39fd8c39","text":"Hospital Delirium Among Older Patients Following Cardiac Surgery: The","text_display":"Hospital Delirium Among Older Patients Following Cardiac Surgery: The","confidence":1,"confidence_rate":1},{"cnt":[[749,525],[1320,525],[1320,557],[749,557]],"region":{"top_left_x":748,"top_left_y":524,"width":573,"height":34},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6cafe05e0e04e429995d6e2ca9316da","type":"text","conversion_output":false,"parent_id":"1dd38b02fb164a5db92a62eb39fd8c39","text":"DEXACET Randomized Clinical Trial","text_display":" DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[246,607],[409,607],[409,646],[246,646]],"region":{"top_left_x":246,"top_left_y":607,"width":163,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36062c786213421aa613cef8360388a3","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Objective","text_display":"Objective","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[744,603],[1883,603],[1883,739],[744,739]],"region":{"top_left_x":744,"top_left_y":602,"width":1140,"height":138},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3d76e9fcd2a4351b21893de3add39f5","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["65dd4832fec549878f94d0689aaccda1","80033e3261994236ab31cfbdfc843f0e","c57e5ba26c324340baaed5cda10310db"],"text":"To evaluate the effect of postoperative IV acetaminophen (paracetamol) vs placebo, combined with IV propofol vs dexmedetomidine, on postoperative delirium among older patients undergoing cardiac surgery","text_display":"To evaluate the effect of postoperative IV acetaminophen (paracetamol) vs placebo, combined with IV propofol vs dexmedetomidine, on postoperative delirium among older patients undergoing cardiac surgery","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,607],[1877,607],[1877,644],[749,644]],"region":{"top_left_x":748,"top_left_y":607,"width":1129,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65dd4832fec549878f94d0689aaccda1","type":"text","conversion_output":false,"parent_id":"e3d76e9fcd2a4351b21893de3add39f5","text":"To evaluate the effect of postoperative IV acetaminophen (paracetamol)","text_display":"To evaluate the effect of postoperative IV acetaminophen (paracetamol)","confidence":1,"confidence_rate":1},{"cnt":[[749,651],[1877,651],[1877,692],[749,692]],"region":{"top_left_x":748,"top_left_y":650,"width":1129,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80033e3261994236ab31cfbdfc843f0e","type":"text","conversion_output":false,"parent_id":"e3d76e9fcd2a4351b21893de3add39f5","text":"vs placebo, combined with IV propofol vs dexmedetomidine, on","text_display":" vs placebo, combined with IV propofol vs dexmedetomidine, on","confidence":1,"confidence_rate":1},{"cnt":[[749,698],[1860,698],[1860,739],[749,739]],"region":{"top_left_x":748,"top_left_y":698,"width":1112,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c57e5ba26c324340baaed5cda10310db","type":"text","conversion_output":false,"parent_id":"e3d76e9fcd2a4351b21893de3add39f5","text":"postoperative delirium among older patients undergoing cardiac surgery","text_display":" postoperative delirium among older patients undergoing cardiac surgery","confidence":1,"confidence_rate":1},{"cnt":[[246,776],[534,776],[534,813],[246,813]],"region":{"top_left_x":246,"top_left_y":776,"width":289,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cbda80448e842fab760e5843a6ce3b1","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Inclusion Criteria","text_display":"Inclusion Criteria","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[747,776],[1881,776],[1881,865],[747,865]],"region":{"top_left_x":746,"top_left_y":776,"width":1136,"height":89},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2cf4888f3c3641279022152276753c06","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["2d10ae7a550a43fe91bcc6b5a0547551","dd8a111a9b274946a90ea80407446ad4"],"text":"Patients 60 years or older undergoing CABG with or without aortic and/or mitral valve replacement requiring cardiopulmonary bypass","text_display":"Patients 60 years or older undergoing CABG with or without aortic and/or mitral valve replacement requiring cardiopulmonary bypass","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,778],[1879,778],[1879,817],[749,817]],"region":{"top_left_x":748,"top_left_y":778,"width":1132,"height":40},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d10ae7a550a43fe91bcc6b5a0547551","type":"text","conversion_output":false,"parent_id":"2cf4888f3c3641279022152276753c06","text":"Patients 60 years or older undergoing CABG with or without aortic and/or","text_display":"Patients 60 years or older undergoing CABG with or without aortic and/or","confidence":1,"confidence_rate":1},{"cnt":[[749,824],[1658,824],[1658,865],[749,865]],"region":{"top_left_x":748,"top_left_y":823,"width":911,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd8a111a9b274946a90ea80407446ad4","type":"text","conversion_output":false,"parent_id":"2cf4888f3c3641279022152276753c06","text":"mitral valve replacement requiring cardiopulmonary bypass","text_display":" mitral valve replacement requiring cardiopulmonary bypass","confidence":1,"confidence_rate":1},{"cnt":[[248,906],[547,906],[547,939],[248,939]],"region":{"top_left_x":248,"top_left_y":906,"width":300,"height":33},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4490b439cc44407593c11135132fff8d","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Exclusion Criteria","text_display":"Exclusion Criteria","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[744,904],[1881,902],[1882,1180],[744,1182]],"region":{"top_left_x":743,"top_left_y":901,"width":1139,"height":282},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d04141aaa664185bfffd93bf26ca1dc","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["5cd914d138894ad8bcdd0d5c5215920a","8671030372364a8c8d959d7fbbcad562","5720d6c9a3464c84adc72caea4a4513d","26e34d3c68f44a2da512cd54b381ad3c","a1b58e94299844e2a1e2fdb5cf6b4885","cb141c3258974294b692e82efc6f86b7"],"text":"Patients with preoperative left ventricular ejection fraction (LVEF) <30\\%, pre-existing cognitive impairment, Alzheimer's disease, Parkinson's disease, medications for cognitive decline, history of recent seizures, serum creatinine \\(>2 mg / dL\\), liver dysfunction, recent history of alcohol abuse, English language limitations, hypersensitivity to study medications, and undergoing emergent surgery","text_display":"Patients with preoperative left ventricular ejection fraction (LVEF) <30\\%, pre-existing cognitive impairment, Alzheimer's disease, Parkinson's disease, medications for cognitive decline, history of recent seizures, serum creatinine \\(>2 mg / dL\\), liver dysfunction, recent history of alcohol abuse, English language limitations, hypersensitivity to study medications, and undergoing emergent surgery","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.7166220190748618,"confidence_rate":0.9992972792024006},{"cnt":[[749,906],[1877,906],[1877,943],[749,943]],"region":{"top_left_x":748,"top_left_y":906,"width":1129,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cd914d138894ad8bcdd0d5c5215920a","type":"text","conversion_output":false,"parent_id":"5d04141aaa664185bfffd93bf26ca1dc","text":"Patients with preoperative left ventricular ejection fraction (LVEF) <30\\%,","text_display":"Patients with preoperative left ventricular ejection fraction (LVEF) <30\\%,","confidence":0.7166220190748618,"confidence_rate":0.9957910755255484},{"cnt":[[749,949],[1877,949],[1877,991],[749,991]],"region":{"top_left_x":748,"top_left_y":949,"width":1129,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8671030372364a8c8d959d7fbbcad562","type":"text","conversion_output":false,"parent_id":"5d04141aaa664185bfffd93bf26ca1dc","text":"pre-existing cognitive impairment, Alzheimer's disease, Parkinson's","text_display":" pre-existing cognitive impairment, Alzheimer's disease, Parkinson's","confidence":1,"confidence_rate":1},{"cnt":[[749,997],[1875,997],[1875,1036],[749,1036]],"region":{"top_left_x":748,"top_left_y":996,"width":1127,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5720d6c9a3464c84adc72caea4a4513d","type":"text","conversion_output":false,"parent_id":"5d04141aaa664185bfffd93bf26ca1dc","text":"disease, medications for cognitive decline, history of recent seizures,","text_display":" disease, medications for cognitive decline, history of recent seizures,","confidence":1,"confidence_rate":1},{"cnt":[[749,1045],[1877,1045],[1877,1086],[749,1086]],"region":{"top_left_x":748,"top_left_y":1044,"width":1129,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26e34d3c68f44a2da512cd54b381ad3c","type":"text","conversion_output":false,"parent_id":"5d04141aaa664185bfffd93bf26ca1dc","text":"serum creatinine \\(>2 mg / dL\\), liver dysfunction, recent history of alcohol","text_display":" serum creatinine \\(>2 mg / dL\\), liver dysfunction, recent history of alcohol","confidence":1,"confidence_rate":1},{"cnt":[[749,1092],[1877,1092],[1877,1131],[749,1131]],"region":{"top_left_x":748,"top_left_y":1092,"width":1129,"height":40},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1b58e94299844e2a1e2fdb5cf6b4885","type":"text","conversion_output":false,"parent_id":"5d04141aaa664185bfffd93bf26ca1dc","text":"abuse, English language limitations, hypersensitivity to study medications,","text_display":" abuse, English language limitations, hypersensitivity to study medications,","confidence":1,"confidence_rate":1},{"cnt":[[749,1138],[1275,1138],[1275,1177],[749,1177]],"region":{"top_left_x":748,"top_left_y":1137,"width":527,"height":40},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb141c3258974294b692e82efc6f86b7","type":"text","conversion_output":false,"parent_id":"5d04141aaa664185bfffd93bf26ca1dc","text":"and undergoing emergent surgery","text_display":" and undergoing emergent surgery","confidence":1,"confidence_rate":1},{"cnt":[[246,1218],[474,1218],[474,1259],[246,1259]],"region":{"top_left_x":246,"top_left_y":1217,"width":228,"height":43},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3795efa074cf4928a83b6cc67432a6ee","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Study Design","text_display":"Study Design","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[747,1216],[1879,1216],[1879,1298],[747,1298]],"region":{"top_left_x":746,"top_left_y":1215,"width":1134,"height":84},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b92a88c77b9a413eb5286334267f35fa","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["8e1440f96ff44c39b5d5fdf7651e30eb","ce47a08bb7c84ccbbbcb725a9c7bb81d"],"text":"Single center, randomized, triple blind, placebo controlled, factorial design clinical trial","text_display":"Single center, randomized, triple blind, placebo controlled, factorial design clinical trial","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,1218],[1877,1218],[1877,1259],[749,1259]],"region":{"top_left_x":748,"top_left_y":1217,"width":1129,"height":43},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e1440f96ff44c39b5d5fdf7651e30eb","type":"text","conversion_output":false,"parent_id":"b92a88c77b9a413eb5286334267f35fa","text":"Single center, randomized, triple blind, placebo controlled, factorial design","text_display":"Single center, randomized, triple blind, placebo controlled, factorial design","confidence":1,"confidence_rate":1},{"cnt":[[749,1261],[922,1261],[922,1298],[749,1298]],"region":{"top_left_x":748,"top_left_y":1261,"width":174,"height":38},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce47a08bb7c84ccbbbcb725a9c7bb81d","type":"text","conversion_output":false,"parent_id":"b92a88c77b9a413eb5286334267f35fa","text":"clinical trial","text_display":" clinical trial","confidence":1,"confidence_rate":1},{"cnt":[[744,1341],[1888,1341],[1888,1614],[744,1614]],"region":{"top_left_x":744,"top_left_y":1341,"width":1144,"height":274},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0933e1268a164a4ca790b22358f2fe8b","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["07bba19f09384d91962b3ec955496f09","0092d81675b34e378c1264c94cb8947f","bde300543205429fbc8bc0a70ef734da","4aef95361a8b410c8cafb845eba4f141","7acbf4a355c74a07a102e323681c3731","ee0337647ed24c6583fe47abb10835d8"],"text":"Patients were randomized to one of four factorial groups which included randomization to receive postoperative analgesia with intravenous acetaminophen or placebo every 6 hours for 48 hours. In addition, patients were randomized to receive postoperative sedation starting at chest closure and continued for up to 6 hours postoperatively or until extubation with intravenous dexmedetomidine or propofol.","text_display":"Patients were randomized to one of four factorial groups which included randomization to receive postoperative analgesia with intravenous acetaminophen or placebo every 6 hours for 48 hours. In addition, patients were randomized to receive postoperative sedation starting at chest closure and continued for up to 6 hours postoperatively or until extubation with intravenous dexmedetomidine or propofol.","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,1343],[1877,1343],[1877,1385],[749,1385]],"region":{"top_left_x":748,"top_left_y":1343,"width":1129,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07bba19f09384d91962b3ec955496f09","type":"text","conversion_output":false,"parent_id":"0933e1268a164a4ca790b22358f2fe8b","text":"Patients were randomized to one of four factorial groups which included","text_display":"Patients were randomized to one of four factorial groups which included","confidence":1,"confidence_rate":1},{"cnt":[[749,1391],[1877,1391],[1877,1430],[749,1430]],"region":{"top_left_x":748,"top_left_y":1391,"width":1129,"height":40},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0092d81675b34e378c1264c94cb8947f","type":"text","conversion_output":false,"parent_id":"0933e1268a164a4ca790b22358f2fe8b","text":"randomization to receive postoperative analgesia with intravenous","text_display":" randomization to receive postoperative analgesia with intravenous","confidence":1,"confidence_rate":1},{"cnt":[[749,1439],[1877,1439],[1877,1476],[749,1476]],"region":{"top_left_x":748,"top_left_y":1438,"width":1129,"height":38},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bde300543205429fbc8bc0a70ef734da","type":"text","conversion_output":false,"parent_id":"0933e1268a164a4ca790b22358f2fe8b","text":"acetaminophen or placebo every 6 hours for 48 hours. In addition, patients","text_display":" acetaminophen or placebo every 6 hours for 48 hours. In addition, patients","confidence":1,"confidence_rate":1},{"cnt":[[749,1482],[1879,1482],[1879,1521],[749,1521]],"region":{"top_left_x":748,"top_left_y":1482,"width":1132,"height":40},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4aef95361a8b410c8cafb845eba4f141","type":"text","conversion_output":false,"parent_id":"0933e1268a164a4ca790b22358f2fe8b","text":"were randomized to receive postoperative sedation starting at chest","text_display":" were randomized to receive postoperative sedation starting at chest","confidence":1,"confidence_rate":1},{"cnt":[[749,1530],[1877,1530],[1877,1567],[749,1567]],"region":{"top_left_x":748,"top_left_y":1529,"width":1129,"height":38},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7acbf4a355c74a07a102e323681c3731","type":"text","conversion_output":false,"parent_id":"0933e1268a164a4ca790b22358f2fe8b","text":"closure and continued for up to 6 hours postoperatively or until extubation","text_display":" closure and continued for up to 6 hours postoperatively or until extubation","confidence":1,"confidence_rate":1},{"cnt":[[749,1573],[1470,1573],[1470,1614],[749,1614]],"region":{"top_left_x":748,"top_left_y":1573,"width":722,"height":42},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee0337647ed24c6583fe47abb10835d8","type":"text","conversion_output":false,"parent_id":"0933e1268a164a4ca790b22358f2fe8b","text":"with intravenous dexmedetomidine or propofol.","text_display":" with intravenous dexmedetomidine or propofol.","confidence":1,"confidence_rate":1},{"cnt":[[744,1653],[1881,1653],[1881,1787],[744,1787]],"region":{"top_left_x":744,"top_left_y":1653,"width":1138,"height":135},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6401b2b1801844d3a1959ed547aff5a7","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["f7f6332b0606462e8b5de02fb2f06162","65671b77316a4774bd50b0ffbb207e5b","f6e1dd6980d64f4c8c29976ad0f851c2"],"text":"The incidence of postoperative in-hospital delirium was assessed daily using the CAM or CAM-ICU during the patient's hospitalization. In addition, follow up assessments were conducted at one month and one year.","text_display":"The incidence of postoperative in-hospital delirium was assessed daily using the CAM or CAM-ICU during the patient's hospitalization. In addition, follow up assessments were conducted at one month and one year.","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,1655],[1877,1655],[1877,1692],[749,1692]],"region":{"top_left_x":748,"top_left_y":1655,"width":1129,"height":38},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7f6332b0606462e8b5de02fb2f06162","type":"text","conversion_output":false,"parent_id":"6401b2b1801844d3a1959ed547aff5a7","text":"The incidence of postoperative in-hospital delirium was assessed daily","text_display":"The incidence of postoperative in-hospital delirium was assessed daily","confidence":1,"confidence_rate":1},{"cnt":[[749,1701],[1875,1701],[1875,1740],[749,1740]],"region":{"top_left_x":748,"top_left_y":1700,"width":1127,"height":40},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65671b77316a4774bd50b0ffbb207e5b","type":"text","conversion_output":false,"parent_id":"6401b2b1801844d3a1959ed547aff5a7","text":"using the CAM or CAM-ICU during the patient's hospitalization. In addition,","text_display":" using the CAM or CAM-ICU during the patient's hospitalization. In addition,","confidence":1,"confidence_rate":1},{"cnt":[[749,1746],[1790,1746],[1790,1787],[749,1787]],"region":{"top_left_x":748,"top_left_y":1746,"width":1043,"height":42},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6e1dd6980d64f4c8c29976ad0f851c2","type":"text","conversion_output":false,"parent_id":"6401b2b1801844d3a1959ed547aff5a7","text":"follow up assessments were conducted at one month and one year.","text_display":" follow up assessments were conducted at one month and one year.","confidence":1,"confidence_rate":1},{"cnt":[[248,1826],[619,1826],[619,1865],[248,1865]],"region":{"top_left_x":248,"top_left_y":1826,"width":371,"height":40},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba8b260ab2944306afa29221bc528d84","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Study Discontinuation","text_display":"Study Discontinuation","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[747,1824],[1881,1824],[1881,1913],[747,1913]],"region":{"top_left_x":746,"top_left_y":1824,"width":1136,"height":90},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"729592e2c76845a7866e7da46569187a","type":"complex_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","children_ids":["b64f8d4467d5496c84d7c8f5a655bcd9","1f0d772590d0490287410f0f7a6216b7"],"text":"Patient request or any serious adverse event thought to be related to study procedures","text_display":"Patient request or any serious adverse event thought to be related to study procedures","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,1829],[1877,1829],[1877,1865],[749,1865]],"region":{"top_left_x":748,"top_left_y":1828,"width":1129,"height":38},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b64f8d4467d5496c84d7c8f5a655bcd9","type":"text","conversion_output":false,"parent_id":"729592e2c76845a7866e7da46569187a","text":"Patient request or any serious adverse event thought to be related to study","text_display":"Patient request or any serious adverse event thought to be related to study","confidence":1,"confidence_rate":1},{"cnt":[[749,1874],[924,1874],[924,1913],[749,1913]],"region":{"top_left_x":748,"top_left_y":1874,"width":177,"height":40},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f0d772590d0490287410f0f7a6216b7","type":"text","conversion_output":false,"parent_id":"729592e2c76845a7866e7da46569187a","text":"procedures","text_display":" procedures","confidence":1,"confidence_rate":1},{"cnt":[[248,1954],[417,1954],[417,1991],[248,1991]],"region":{"top_left_x":248,"top_left_y":1954,"width":170,"height":37},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81a44a5829b344679130117df849baec","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Key Roles","text_display":"Key Roles","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,1954],[1695,1954],[1695,1995],[749,1995]],"region":{"top_left_x":748,"top_left_y":1954,"width":948,"height":42},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e689b08caf04f62843f61c0623e3b4c","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Principal Investigator: Balachundhar Subramaniam, MD MPH","text_display":"Principal Investigator: Balachundhar Subramaniam, MD MPH","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[749,2034],[1704,2034],[1704,2071],[749,2071]],"region":{"top_left_x":748,"top_left_y":2034,"width":956,"height":38},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ef7ba7f93ef4086b1de2c6ceb11eb96","type":"simple_cell","conversion_output":false,"parent_id":"c3a4937954624fdfb027bb89db43ff73","text":"Institution: Beth Israel Deaconess Medical Center, Boston MA","text_display":"Institution: Beth Israel Deaconess Medical Center, Boston MA","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bcf0808cd50439ea0db40f5b027a4bd","type":"page_info","conversion_output":false,"text":"3","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-04","page":4,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b8c57d4051a48b794ae854ecf1b7584","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c89dd0c9ca0425ebefc8bf48118d8db","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7eb8b59006d349baa4bbd0abd9844a48","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,245],[748,245],[748,299],[241,299]],"region":{"top_left_x":240,"top_left_y":244,"width":508,"height":55},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8626c4b1c7a84980991de4e53d1984e5","type":"section_header","conversion_output":false,"children_ids":["8bd13bf08bcf42ae906d25b11724599a"],"text":"","text_display":""},{"cnt":[[245,249],[741,249],[741,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":498,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bd13bf08bcf42ae906d25b11724599a","type":"text","conversion_output":true,"parent_id":"8626c4b1c7a84980991de4e53d1984e5","text":"Significance and Background","text_display":"\n\n\\section*{Significance and Background}","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1882,296],[1882,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1639,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9cc989d9de14f208d891e9d70542c9a","type":"text","conversion_output":true,"text":"Approximately \\(50 \\%\\) of patients have postoperative delirium following cardiac surgery \\({ }^{1}\\). The growing body","text_display":"\n\nApproximately \\(50 \\%\\) of patients have postoperative delirium following cardiac surgery \\({ }^{1}\\). The growing body","confidence":0.99462890625,"confidence_rate":0.9999558569584918},{"cnt":[[245,339],[1880,339],[1880,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccb60e9ed28849ad8f848dc85d516480","type":"text","conversion_output":true,"text":"of evidence suggests that in-hospital delirium is associated with poor hospital outcomes, including a tenfold","text_display":" of evidence suggests that in-hospital delirium is associated with poor hospital outcomes, including a tenfold","confidence":1,"confidence_rate":1},{"cnt":[[245,387],[1880,387],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":386,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7016691365844737a3befede41e77aca","type":"text","conversion_output":true,"text":"increased risk of death, and a fivefold increased risk of nosocomial related complications \\({ }^{2}\\). Delirium has","text_display":" increased risk of death, and a fivefold increased risk of nosocomial related complications \\({ }^{2}\\). Delirium has","confidence":1,"confidence_rate":1},{"cnt":[[245,434],[1880,434],[1880,479],[245,479]],"region":{"top_left_x":244,"top_left_y":433,"width":1636,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54bac74ab43f4b94b7fa8e7363a4e84e","type":"text","conversion_output":true,"text":"also been associated with serious longer term outcomes such as poor functional recovery, and most","text_display":" also been associated with serious longer term outcomes such as poor functional recovery, and most","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[1880,477],[1880,526],[245,526]],"region":{"top_left_x":244,"top_left_y":476,"width":1636,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32a0258e9cfe4e9d96b8de72429cb7ad","type":"text","conversion_output":true,"text":"recently, impaired cognitive function for up to one year after cardiac surgery \\({ }^{3}\\). Importantly, intervenable","text_display":" recently, impaired cognitive function for up to one year after cardiac surgery \\({ }^{3}\\). Importantly, intervenable","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1880,524],[1880,569],[245,569]],"region":{"top_left_x":244,"top_left_y":524,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"866877c75ff64cc0881d7e6a60099ce8","type":"text","conversion_output":true,"text":"factors, such as perioperative sedation and analgesia with opioids may contribute to the etiology of delirium.","text_display":" factors, such as perioperative sedation and analgesia with opioids may contribute to the etiology of delirium.","confidence":1,"confidence_rate":1},{"cnt":[[245,571],[1880,571],[1880,617],[245,617]],"region":{"top_left_x":244,"top_left_y":571,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"944f75c13a4c4405a56303cb35af9c57","type":"text","conversion_output":true,"text":"In the setting of cardiac surgery done increasingly in older patients, there is an urgent need to test","text_display":" In the setting of cardiac surgery done increasingly in older patients, there is an urgent need to test","confidence":1,"confidence_rate":1},{"cnt":[[245,619],[1212,619],[1212,664],[245,664]],"region":{"top_left_x":244,"top_left_y":618,"width":968,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d271dc38ae1846c2baf879fa28333997","type":"text","conversion_output":true,"text":"alternative sedation and complementary analgesic techniques.","text_display":" alternative sedation and complementary analgesic techniques.","confidence":1,"confidence_rate":1},{"cnt":[[245,698],[1880,698],[1880,743],[245,743]],"region":{"top_left_x":244,"top_left_y":698,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08a463a4c01c40b588dfa88c17adb231","type":"text","conversion_output":true,"text":"Dexmedetomidine, a selective alpha-2 receptor agonist, provides sedation without causing respiratory","text_display":"\n\nDexmedetomidine, a selective alpha-2 receptor agonist, provides sedation without causing respiratory","confidence":0.99462890625,"confidence_rate":0.999948710173153},{"cnt":[[245,743],[1878,743],[1878,788],[245,788]],"region":{"top_left_x":244,"top_left_y":743,"width":1634,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b8fc58e7060473ba3e546d042bc35c8","type":"text","conversion_output":true,"text":"depression. Dexmedetomidine is also suggested to have an opioid sparing effect that makes it a unique","text_display":" depression. Dexmedetomidine is also suggested to have an opioid sparing effect that makes it a unique","confidence":1,"confidence_rate":1},{"cnt":[[245,791],[1880,791],[1880,836],[245,836]],"region":{"top_left_x":244,"top_left_y":790,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2a34edcfcf24bb08873802fadc50fcf","type":"text","conversion_output":true,"text":"sedative drug. Currently used sedation drugs (midazolam) release deliriogenic mediators through binding","text_display":" sedative drug. Currently used sedation drugs (midazolam) release deliriogenic mediators through binding","confidence":1,"confidence_rate":1},{"cnt":[[245,836],[1878,836],[1878,881],[245,881]],"region":{"top_left_x":244,"top_left_y":835,"width":1634,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3058e5415e0e469f85df272de36e8e43","type":"text","conversion_output":true,"text":"of Gamma-aminobutyric Acid (GABA) receptors. Dexmedetomidine has no effect on the GABA receptors.","text_display":" of Gamma-aminobutyric Acid (GABA) receptors. Dexmedetomidine has no effect on the GABA receptors.","confidence":1,"confidence_rate":1},{"cnt":[[245,881],[1878,881],[1878,926],[245,926]],"region":{"top_left_x":244,"top_left_y":880,"width":1634,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e037171988e4a10ac05bfa3f585c859","type":"text","conversion_output":true,"text":"Although these characteristics suggest dexmedetomidine to be a unique and promising drug for sedation","text_display":" Although these characteristics suggest dexmedetomidine to be a unique and promising drug for sedation","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1876,928],[1876,973],[245,973]],"region":{"top_left_x":244,"top_left_y":928,"width":1632,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"048a11ad94944b54a94064389a9e1d94","type":"text","conversion_output":true,"text":"following cardiac surgery, its efficacy on reducing the incidence, duration and long term effects of delirium","text_display":" following cardiac surgery, its efficacy on reducing the incidence, duration and long term effects of delirium","confidence":1,"confidence_rate":1},{"cnt":[[245,973],[758,973],[758,1018],[245,1018]],"region":{"top_left_x":244,"top_left_y":973,"width":515,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0815d6ef586447dcb6bf3ae0fcba8807","type":"text","conversion_output":true,"text":"has not been studied thoroughly.","text_display":" has not been studied thoroughly.","confidence":0.99951171875,"confidence_rate":0.9999868000736574},{"cnt":[[245,1053],[1880,1053],[1880,1098],[245,1098]],"region":{"top_left_x":244,"top_left_y":1052,"width":1636,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fc51414deb44a9fab2ca9232c03228e","type":"text","conversion_output":true,"text":"Studies involving use of dexmedetomidine in an attempt to reduce the incidence of delirium in cardiac","text_display":"\n\nStudies involving use of dexmedetomidine in an attempt to reduce the incidence of delirium in cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[1880,1100],[1880,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1100,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d61d55dca88e4d11b7e518c2095c7e79","type":"text","conversion_output":true,"text":"surgical patients provide conflicting results. One meta-analysis concluded that dexmedetomidine in cardiac","text_display":" surgical patients provide conflicting results. One meta-analysis concluded that dexmedetomidine in cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1878,1147],[1878,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1147,"width":1634,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5374abd99cf49c29b5bf9564dd32a68","type":"text","conversion_output":true,"text":"surgery shortened the ventilator time (but not the Intensive Care Unit (ICU) or hospital length of stay),","text_display":" surgery shortened the ventilator time (but not the Intensive Care Unit (ICU) or hospital length of stay),","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1880,1190],[1880,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1190,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"900f12c2e362464c9858c51dcd9250fe","type":"text","conversion_output":true,"text":"reduced the incidence of postoperative ventricular arrhythmias and delirium in cardiac surgical patients \\({ }^{4}\\).","text_display":" reduced the incidence of postoperative ventricular arrhythmias and delirium in cardiac surgical patients \\({ }^{4}\\).","confidence":1,"confidence_rate":1},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ed27082e3764675a9fd5eadf63e0ddd","type":"text","conversion_output":true,"text":"However, there are several issues with this meta-analysis, particularly for the systematic assessment of","text_display":" However, there are several issues with this meta-analysis, particularly for the systematic assessment of","confidence":1,"confidence_rate":1},{"cnt":[[245,1285],[1880,1285],[1880,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1284,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50af089697e2499e97b75481037a5dd3","type":"text","conversion_output":true,"text":"postoperative delirium. The problems with the four studies that formed the basis of this meta-analysis are","text_display":" postoperative delirium. The problems with the four studies that formed the basis of this meta-analysis are","confidence":1,"confidence_rate":1},{"cnt":[[245,1332],[831,1332],[831,1377],[245,1377]],"region":{"top_left_x":244,"top_left_y":1332,"width":588,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55776193efd14b338dc6df0bce565fd2","type":"text","conversion_output":true,"text":"explained in the next few paragraphs.","text_display":" explained in the next few paragraphs.","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1880,1409],[1880,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1409,"width":1636,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1470df95f05d4faf92119ce61df8652c","type":"text","conversion_output":true,"text":"In a retrospective study \\({ }^{5}\\) of administrative database from 250 hospitals, the incidence of postoperative","text_display":"\n\nIn a retrospective study \\({ }^{5}\\) of administrative database from 250 hospitals, the incidence of postoperative","confidence":1,"confidence_rate":1},{"cnt":[[245,1457],[1880,1457],[1880,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1456,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56d52ff7a20f466d977b3c4904c2fe9c","type":"text","conversion_output":true,"text":"delirium following cardiac surgery was significantly decreased with associated cost savings in the","text_display":" delirium following cardiac surgery was significantly decreased with associated cost savings in the","confidence":1,"confidence_rate":1},{"cnt":[[245,1502],[1880,1502],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1501,"width":1636,"height":49},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"058ff964431e4fe696586b2d4c77be87","type":"text","conversion_output":true,"text":"dexmedetomidine group. This study compared two regimens (dexmedetomidine, propofol plus narcotics","text_display":" dexmedetomidine group. This study compared two regimens (dexmedetomidine, propofol plus narcotics","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1880,1547],[1880,1592],[245,1592]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a774e515d6546d6acf91da45df9b9aa","type":"text","conversion_output":true,"text":"vs. propofol vs. narcotics). Propofol was used in the dexmedetomidine group as well. This trial specifically","text_display":" vs. propofol vs. narcotics). Propofol was used in the dexmedetomidine group as well. This trial specifically","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1300,1594],[1300,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1594,"width":1056,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a62e5e5c079b40228542e9c97ab223ba","type":"text","conversion_output":true,"text":"does not mention how delirium was assessed in individual hospitals.","text_display":" does not mention how delirium was assessed in individual hospitals.","confidence":1,"confidence_rate":1},{"cnt":[[245,1676],[1880,1676],[1880,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1675,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b1468a2921d46a9a82a1895ecc6fba2","type":"text","conversion_output":true,"text":"A randomized controlled trial \\({ }^{6}\\) comparing dexmedetomidine/propofol to morphine/propofol in cardiac","text_display":"\n\nA randomized controlled trial \\({ }^{6}\\) comparing dexmedetomidine/propofol to morphine/propofol in cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1880,1721],[1880,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1720,"width":1636,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b0657e1bc1451eb8d90ac4c0e4865b","type":"text","conversion_output":true,"text":"surgery patients showed a decreased duration of delirium ( 5 days to 2 days) in the dexmedetomidine group.","text_display":" surgery patients showed a decreased duration of delirium ( 5 days to 2 days) in the dexmedetomidine group.","confidence":0.9990236759185791,"confidence_rate":0.9999916513083871},{"cnt":[[245,1766],[1880,1766],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1766,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a323d98d35ab4aa89cc08dd25a1d89e1","type":"text","conversion_output":true,"text":"This study found a similar incidence of delirium in both the groups. Propofol was used as a sedative in both","text_display":" This study found a similar incidence of delirium in both the groups. Propofol was used as a sedative in both","confidence":1,"confidence_rate":1},{"cnt":[[245,1813],[1880,1813],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1813,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6585d6105b14264a8a8015ce9c91aff","type":"text","conversion_output":true,"text":"the groups and this could have attributed to similar incidences of delirium in both the groups. There is a","text_display":" the groups and this could have attributed to similar incidences of delirium in both the groups. There is a","confidence":1,"confidence_rate":1},{"cnt":[[245,1858],[1880,1858],[1880,1904],[245,1904]],"region":{"top_left_x":244,"top_left_y":1858,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c749446f664f4859b2d4d94205bddd21","type":"text","conversion_output":true,"text":"possibility the study was not powered adequately as the baseline incidence of delirium in the control group","text_display":" possibility the study was not powered adequately as the baseline incidence of delirium in the control group","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1880,1904],[1880,1949],[245,1949]],"region":{"top_left_x":244,"top_left_y":1903,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90a49afae853449383f6e962eb47f85d","type":"text","conversion_output":true,"text":"was a surprisingly low \\(15 \\%\\), much lower than other cardiac surgery studies that have employed state-of-","text_display":" was a surprisingly low \\(15 \\%\\), much lower than other cardiac surgery studies that have employed state-of","confidence":0.92626953125,"confidence_rate":0.9993102378491932},{"cnt":[[245,1951],[1880,1951],[1880,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1950,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3766d883dcb9472880a042741187fe52","type":"text","conversion_output":true,"text":"the art delirium measures. This study used CAM-ICU for assessing delirium both in intubated and extubated","text_display":"the art delirium measures. This study used CAM-ICU for assessing delirium both in intubated and extubated","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,1996],[1878,1996],[1878,2041],[245,2041]],"region":{"top_left_x":244,"top_left_y":1995,"width":1634,"height":47},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29dbb5aea2c94469b76b39e9510dd593","type":"text","conversion_output":true,"text":"patients. While the CAM-ICU, a delirium assessment that does not require any verbal responses by the","text_display":" patients. While the CAM-ICU, a delirium assessment that does not require any verbal responses by the","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1876,2041],[1876,2086],[245,2086]],"region":{"top_left_x":244,"top_left_y":2041,"width":1632,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98c7affe1ea04b488987063bd671f144","type":"text","conversion_output":true,"text":"patient, is state-of-the-art for intubated patients, it has reduced sensitivity for delirium in verbal patients.","text_display":" patient, is state-of-the-art for intubated patients, it has reduced sensitivity for delirium in verbal patients.","confidence":1,"confidence_rate":1},{"cnt":[[245,2088],[1253,2088],[1253,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2088,"width":1009,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23d6500c15b24eba87ca3ccb04873ce1","type":"text","conversion_output":true,"text":"This design could have underestimated the incidence of delirium.","text_display":" This design could have underestimated the incidence of delirium.","confidence":1,"confidence_rate":1},{"cnt":[[245,2168],[1880,2168],[1880,2215],[245,2215]],"region":{"top_left_x":244,"top_left_y":2167,"width":1636,"height":49},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3986e51da33d44b19abf4d63e5aca203","type":"text","conversion_output":true,"text":"The third study \\({ }^{7}\\) included in the meta-analysis was a prospective, randomized, open labeled trial comparing","text_display":"\n\nThe third study \\({ }^{7}\\) included in the meta-analysis was a prospective, randomized, open labeled trial comparing","confidence":1,"confidence_rate":1},{"cnt":[[245,2213],[1880,2213],[1880,2260],[245,2260]],"region":{"top_left_x":244,"top_left_y":2212,"width":1636,"height":49},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c920f8ddaf04d1bb2b5a4e4b618819f","type":"text","conversion_output":true,"text":"three groups (dexmedetomidine, midazolam, and propofol). This study reported a dramatically decreased","text_display":" three groups (dexmedetomidine, midazolam, and propofol). This study reported a dramatically decreased","confidence":0.998046875,"confidence_rate":0.9999815564452184},{"cnt":[[245,2260],[1880,2260],[1880,2305],[245,2305]],"region":{"top_left_x":244,"top_left_y":2260,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50a549a812754055a2bdff2ddbc9c691","type":"text","conversion_output":true,"text":"incidence of delirium in the dexmedetomidine group, \\(3 \\%\\), compared to \\(50 \\%\\) in propofol and midazolam","text_display":" incidence of delirium in the dexmedetomidine group, \\(3 \\%\\), compared to \\(50 \\%\\) in propofol and midazolam","confidence":0.9990236759185791,"confidence_rate":0.9999910385631244},{"cnt":[[245,2307],[1878,2307],[1878,2353],[245,2353]],"region":{"top_left_x":244,"top_left_y":2307,"width":1634,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f9affb616034debbda4bea5fb168815","type":"text","conversion_output":true,"text":"groups. This was a small study, with only 118 patients were recruited and only 90 patients finally analyzed,","text_display":" groups. This was a small study, with only 118 patients were recruited and only 90 patients finally analyzed,","confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"842fed55ae1046ddb49750f375b4553b","type":"page_info","conversion_output":false,"text":"4","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-05","page":5,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b048c288bbd4e9e9fc1c551dc69d438","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e96d08fbdef94107af673278d0d7ae1c","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5d32d76c4c147109b7fc1eca9279cdb","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1880,249],[1880,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0306d769ceab443ba6456174e7eaa3db","type":"text","conversion_output":true,"text":"with 28 patients randomized patients excluded for protocol violations. This introduces a significant selection","text_display":" with 28 patients randomized patients excluded for protocol violations. This introduces a significant selection","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87bf3a6d00f14faf89d5358715b1a1ef","type":"text","conversion_output":true,"text":"bias. Furthermore, a \\(94 \\%\\) reduction in the incidence of delirium was seen in this study. This effect size is","text_display":" bias. Furthermore, a \\(94 \\%\\) reduction in the incidence of delirium was seen in this study. This effect size is","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00a53d2508de4d0390ddb3f17839b1e4","type":"text","conversion_output":true,"text":"almost implausibly large and has not been seen in other studies. Nevertheless, this study can provide a","text_display":" almost implausibly large and has not been seen in other studies. Nevertheless, this study can provide a","confidence":1,"confidence_rate":1},{"cnt":[[245,387],[1452,387],[1452,432],[245,432]],"region":{"top_left_x":244,"top_left_y":386,"width":1209,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10442867985b4cfa84266142e7758191","type":"text","conversion_output":true,"text":"framework for sample size for future studies assuming the best case scenario.","text_display":" framework for sample size for future studies assuming the best case scenario.","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1880,468],[1880,513],[245,513]],"region":{"top_left_x":244,"top_left_y":468,"width":1636,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2473d2729654465b9ccdae041bab9c64","type":"text","conversion_output":true,"text":"The final study \\({ }^{8}\\) included in the meta-analysis was a prospective randomized control trial of 89 patients","text_display":"\n\nThe final study \\({ }^{8}\\) included in the meta-analysis was a prospective randomized control trial of 89 patients","confidence":0.99755859375,"confidence_rate":0.9999801270971291},{"cnt":[[245,511],[1880,511],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58ced9be6fac45589f3ce57d7032deac","type":"text","conversion_output":true,"text":"undergoing non emergent CABG. In this study, a patient satisfaction questionnaire was used to assess","text_display":" undergoing non emergent CABG. In this study, a patient satisfaction questionnaire was used to assess","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7823eb82323d41faa13b6eabbe153548","type":"text","conversion_output":true,"text":"pain, comfort and extubation process between intravenous dexmedetomidine and propofol groups. One","text_display":" pain, comfort and extubation process between intravenous dexmedetomidine and propofol groups. One","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1878,606],[1878,651],[245,651]],"region":{"top_left_x":244,"top_left_y":605,"width":1634,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55897d6298f141e0b587ac3c0deca146","type":"text","conversion_output":true,"text":"patient in each group was reported to have delirium. This study was not designed to identify patients with","text_display":" patient in each group was reported to have delirium. This study was not designed to identify patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,649],[1878,649],[1878,696],[245,696]],"region":{"top_left_x":244,"top_left_y":648,"width":1634,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc30772c76444413bc74866e7cf0d65f","type":"text","conversion_output":true,"text":"delirium with any specific tools such as CAM and thus could have grossly underestimated delirium","text_display":" delirium with any specific tools such as CAM and thus could have grossly underestimated delirium","confidence":1,"confidence_rate":1},{"cnt":[[245,696],[1880,696],[1880,743],[245,743]],"region":{"top_left_x":244,"top_left_y":696,"width":1636,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dff57b81d20845639520c062825d5444","type":"text","conversion_output":true,"text":"incidence. Thus, the meta-analysis represents a combination of poorly designed studies with differing","text_display":" incidence. Thus, the meta-analysis represents a combination of poorly designed studies with differing","confidence":1,"confidence_rate":1},{"cnt":[[245,743],[1876,743],[1876,788],[245,788]],"region":{"top_left_x":244,"top_left_y":743,"width":1632,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa717ec3737b4143bcc3d79f5ed4e970","type":"text","conversion_output":true,"text":"measurements, and is extremely unlikely to create a significant impact or practice change among clinicians.","text_display":" measurements, and is extremely unlikely to create a significant impact or practice change among clinicians.","confidence":1,"confidence_rate":1},{"cnt":[[245,791],[1772,791],[1772,836],[245,836]],"region":{"top_left_x":244,"top_left_y":790,"width":1529,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8e4142ce5a049fbb99927fce518dcf1","type":"text","conversion_output":true,"text":"Therefore, these findings will not result in a practice change in cardiac surgical intensive care units.","text_display":" Therefore, these findings will not result in a practice change in cardiac surgical intensive care units.","confidence":1,"confidence_rate":1},{"cnt":[[245,872],[1880,872],[1880,917],[245,917]],"region":{"top_left_x":244,"top_left_y":872,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"659a14ae1825465fa4b154894b746081","type":"text","conversion_output":true,"text":"Postoperative pain following cardiac surgery can be due to the sternal incision, chest tube sites and leg","text_display":"\n\nPostoperative pain following cardiac surgery can be due to the sternal incision, chest tube sites and leg","confidence":1,"confidence_rate":1},{"cnt":[[245,915],[1880,915],[1880,960],[245,960]],"region":{"top_left_x":244,"top_left_y":915,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8866afa64bb447aca46ea5c9bdb269f6","type":"text","conversion_output":true,"text":"incisions. Current pain relief strategy includes postoperative opioid administration (IV morphine or","text_display":" incisions. Current pain relief strategy includes postoperative opioid administration (IV morphine or","confidence":1,"confidence_rate":1},{"cnt":[[245,958],[1880,958],[1880,1008],[245,1008]],"region":{"top_left_x":244,"top_left_y":958,"width":1636,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2feb162b6d843a690f35999b853c876","type":"text","conversion_output":true,"text":"hydromorphone). While, inadequate pain relief increases the risk of postoperative delirium, opioids with","text_display":" hydromorphone). While, inadequate pain relief increases the risk of postoperative delirium, opioids with","confidence":1,"confidence_rate":1},{"cnt":[[245,1008],[1876,1008],[1876,1055],[245,1055]],"region":{"top_left_x":244,"top_left_y":1007,"width":1632,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dda69f3601804236924f8e50bf71a7d0","type":"text","conversion_output":true,"text":"their psychoactive properties also increase the risk of postoperative delirium, especially in elderly patients.","text_display":" their psychoactive properties also increase the risk of postoperative delirium, especially in elderly patients.","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1880,1053],[1880,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1052,"width":1636,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42c78cd9858344dc9f6eb958b8c0a6e7","type":"text","conversion_output":true,"text":"A multimodal balanced postoperative pain management is advantageous and provides several beneficial","text_display":" A multimodal balanced postoperative pain management is advantageous and provides several beneficial","confidence":1,"confidence_rate":1},{"cnt":[[245,1100],[1880,1100],[1880,1145],[245,1145]],"region":{"top_left_x":244,"top_left_y":1100,"width":1636,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a31b37fc6e684e97875e682faa25b70f","type":"text","conversion_output":true,"text":"effects. The options in cardiac surgery would include nonsteroidal anti-inflammatory drugs and","text_display":" effects. The options in cardiac surgery would include nonsteroidal anti-inflammatory drugs and","confidence":1,"confidence_rate":1},{"cnt":[[245,1145],[1878,1145],[1878,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1145,"width":1634,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01646c292dfb41a2961575df5f1c710a","type":"text","conversion_output":true,"text":"acetaminophen. Their postoperative use decreases the exposure of older patients to opioids and can be","text_display":" acetaminophen. Their postoperative use decreases the exposure of older patients to opioids and can be","confidence":1,"confidence_rate":1},{"cnt":[[245,1190],[1880,1190],[1880,1240],[245,1240]],"region":{"top_left_x":244,"top_left_y":1190,"width":1636,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03713c76c8334f83a1c234a2372eff54","type":"text","conversion_output":true,"text":"an effective delirium prevention strategy. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) have","text_display":" an effective delirium prevention strategy. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) have","confidence":0.9990234375,"confidence_rate":0.9999900302573734},{"cnt":[[245,1238],[1880,1238],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1237,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d78a66817d34becbfdd2239582de3d2","type":"text","conversion_output":true,"text":"contraindications after many kinds of surgery, including cardiac surgery, which include their deleterious","text_display":" contraindications after many kinds of surgery, including cardiac surgery, which include their deleterious","confidence":1,"confidence_rate":1},{"cnt":[[245,1283],[1076,1283],[1076,1330],[245,1330]],"region":{"top_left_x":244,"top_left_y":1282,"width":833,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1c424ee2c504fe3ac193e0e86e9a982","type":"text","conversion_output":true,"text":"effects on the gastrointestinal tract and renal function.","text_display":" effects on the gastrointestinal tract and renal function.","confidence":1,"confidence_rate":1},{"cnt":[[245,1362],[1880,1362],[1880,1412],[245,1412]],"region":{"top_left_x":244,"top_left_y":1362,"width":1636,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"faeb839ecab4434d91a7786b92292480","type":"text","conversion_output":true,"text":"Acetaminophen has no psychoactive properties and is an attractive option as it lacks bleeding risks","text_display":"\n\nAcetaminophen has no psychoactive properties and is an attractive option as it lacks bleeding risks","confidence":1,"confidence_rate":1},{"cnt":[[245,1409],[1880,1409],[1880,1457],[245,1457]],"region":{"top_left_x":244,"top_left_y":1409,"width":1636,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51466f78c2214041b93deb391d1f073d","type":"text","conversion_output":true,"text":"associated with nonsteroidal agents. Acetaminophen is for the most part safe but could cause liver","text_display":" associated with nonsteroidal agents. Acetaminophen is for the most part safe but could cause liver","confidence":1,"confidence_rate":1},{"cnt":[[245,1454],[1878,1454],[1878,1502],[245,1502]],"region":{"top_left_x":244,"top_left_y":1454,"width":1634,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1db0291f06054620b6027a7fcc198808","type":"text","conversion_output":true,"text":"dysfunction in rare instances. Oral administration of acetaminophen achieves limited blood levels in","text_display":" dysfunction in rare instances. Oral administration of acetaminophen achieves limited blood levels in","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[1880,1500],[1880,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1636,"height":51},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2a0351f94f541c8b81890228bf9d690","type":"text","conversion_output":true,"text":"critically ill patients and therefore has limited efficacy. IV acetaminophen addresses this by allowing","text_display":" critically ill patients and therefore has limited efficacy. IV acetaminophen addresses this by allowing","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1880,1547],[1880,1594],[245,1594]],"region":{"top_left_x":244,"top_left_y":1546,"width":1636,"height":49},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f22ce78e5f6f4bb0adc3d2ecc98387a2","type":"text","conversion_output":true,"text":"administration in critically ill patients and providing superior bioavailability to oral preparations \\({ }^{9}\\). This","text_display":" administration in critically ill patients and providing superior bioavailability to oral preparations \\({ }^{9}\\). This","confidence":1,"confidence_rate":1},{"cnt":[[245,1592],[1880,1592],[1880,1639],[245,1639]],"region":{"top_left_x":244,"top_left_y":1591,"width":1636,"height":49},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de666e9fd80b4ce49ed785ddd24dd466","type":"text","conversion_output":true,"text":"approach has been shown to reduce pain intensity and also decrease the rescue intravenous morphine","text_display":" approach has been shown to reduce pain intensity and also decrease the rescue intravenous morphine","confidence":0.986328125,"confidence_rate":0.9998663565450225},{"cnt":[[245,1637],[827,1637],[827,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1637,"width":584,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a69094885894de9b80c0484e5937dad","type":"text","conversion_output":true,"text":"used during the postoperative period.","text_display":" used during the postoperative period.","confidence":1,"confidence_rate":1},{"cnt":[[245,1721],[1878,1721],[1878,1766],[245,1766]],"region":{"top_left_x":244,"top_left_y":1720,"width":1634,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3516afacbfd54cebb307ab7cb142498a","type":"text","conversion_output":true,"text":"IV acetaminophen has never been studied in the context of cardiac surgery and delirium prevention.","text_display":"\n\nIV acetaminophen has never been studied in the context of cardiac surgery and delirium prevention.","confidence":1,"confidence_rate":1},{"cnt":[[245,1764],[1880,1764],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1763,"width":1636,"height":49},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0726d3fb389c4754b506ad677256a752","type":"text","conversion_output":true,"text":"Additionally, comparing IV acetaminophen as an adjuvant analgesic in combination with IV propofol or IV","text_display":" Additionally, comparing IV acetaminophen as an adjuvant analgesic in combination with IV propofol or IV","confidence":1,"confidence_rate":1},{"cnt":[[245,1811],[1880,1811],[1880,1858],[245,1858]],"region":{"top_left_x":244,"top_left_y":1811,"width":1636,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"321c6b8960b84b8fae437549ffdca6e7","type":"text","conversion_output":true,"text":"dexmedetomidine may ascertain additive or synergistic effects on delirium prevention. Our randomized,","text_display":" dexmedetomidine may ascertain additive or synergistic effects on delirium prevention. Our randomized,","confidence":1,"confidence_rate":1},{"cnt":[[245,1858],[1880,1858],[1880,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1858,"width":1636,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfbe2be4c3bf47a38c60262a666c8290","type":"text","conversion_output":true,"text":"single-blind, pre-pilot study with 12 patients showed that in patients who received IV acetaminophen as","text_display":" single-blind, pre-pilot study with 12 patients showed that in patients who received IV acetaminophen as","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1878,1904],[1878,1951],[245,1951]],"region":{"top_left_x":244,"top_left_y":1903,"width":1634,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78ea2d047b1d487ea4abbde554b2e885","type":"text","conversion_output":true,"text":"adjuvant analgesic \\(( N =6)\\), the incidence of delirium was \\(17 \\%(1 / 6)\\) compared to \\(67 \\%(4 / 6)\\) in those who did","text_display":" adjuvant analgesic \\(( N =6)\\), the incidence of delirium was \\(17 \\%(1 / 6)\\) compared to \\(67 \\%(4 / 6)\\) in those who did","confidence":0.6996548933778968,"confidence_rate":0.9970280244642382},{"cnt":[[245,1951],[1880,1951],[1880,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1950,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6348f55b639441afb583760df2ca1999","type":"text","conversion_output":true,"text":"not. The total incidence was \\(42 \\%(5 / 12)\\). Despite the small sample size, this provocative finding suggests","text_display":" not. The total incidence was \\(42 \\%(5 / 12)\\). Despite the small sample size, this provocative finding suggests","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[245,1994],[1878,1994],[1878,2043],[245,2043]],"region":{"top_left_x":244,"top_left_y":1993,"width":1634,"height":51},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e1bccd5181c490aafd4b457787fcd36","type":"text","conversion_output":true,"text":"that IV acetaminophen with propofol or dexmedetomidine may offer a significant benefit in reducing the","text_display":" that IV acetaminophen with propofol or dexmedetomidine may offer a significant benefit in reducing the","confidence":1,"confidence_rate":1},{"cnt":[[245,2041],[1880,2041],[1880,2088],[245,2088]],"region":{"top_left_x":244,"top_left_y":2041,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c76ce355c5914c71a6030593293672ed","type":"text","conversion_output":true,"text":"incidence of delirium following cardiac surgery. If this benefit is proved in a larger study as proposed, this","text_display":" incidence of delirium following cardiac surgery. If this benefit is proved in a larger study as proposed, this","confidence":1,"confidence_rate":1},{"cnt":[[245,2088],[1179,2088],[1179,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2088,"width":936,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f238d4f7d3394a3ca62074fc1a37d4a4","type":"text","conversion_output":true,"text":"will have a significant impact in patient care and satisfaction.","text_display":" will have a significant impact in patient care and satisfaction.","confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c02b9f361c1e4b728a1b12a6161856e2","type":"page_info","conversion_output":false,"text":"5","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-06","page":6,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"505804baf97e46df8701e421ea1fc408","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3852e9db346a4229868815ef7e7b725b","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2d81afe7d954f98b9e30d910a3732c4","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,245],[599,245],[599,299],[241,299]],"region":{"top_left_x":240,"top_left_y":244,"width":360,"height":55},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14ed57d901fb41a59e402d4b8f1ca60f","type":"section_header","conversion_output":false,"children_ids":["49b631a7e409431f97dda246df33ccbb"],"text":"","text_display":""},{"cnt":[[245,249],[593,249],[593,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":349,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49b631a7e409431f97dda246df33ccbb","type":"text","conversion_output":true,"parent_id":"14ed57d901fb41a59e402d4b8f1ca60f","text":"Subject Recruitment","text_display":"\n\n\\section*{Subject Recruitment}","confidence":1,"confidence_rate":1},{"cnt":[[241,327],[419,327],[419,380],[241,380]],"region":{"top_left_x":240,"top_left_y":326,"width":179,"height":55},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b42ea235f5e4b05941f8f61ea7be91b","type":"section_header","conversion_output":false,"children_ids":["a0f7151b3168431a81d6a0a6a4985db7"],"text":"","text_display":""},{"cnt":[[245,331],[415,331],[415,376],[245,376]],"region":{"top_left_x":244,"top_left_y":330,"width":171,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0f7151b3168431a81d6a0a6a4985db7","type":"text","conversion_output":true,"parent_id":"1b42ea235f5e4b05941f8f61ea7be91b","text":"Screening","text_display":"\n\n\\section*{Screening}","confidence":1,"confidence_rate":1},{"cnt":[[245,374],[1880,374],[1880,423],[245,423]],"region":{"top_left_x":244,"top_left_y":373,"width":1636,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e9a6b840658492fb11df523be5a2660","type":"text","conversion_output":true,"text":"Eligible participants will be identified at preadmission testing clinic appointments, in the cardiac","text_display":"\n\nEligible participants will be identified at preadmission testing clinic appointments, in the cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,421],[1880,421],[1880,466],[245,466]],"region":{"top_left_x":244,"top_left_y":421,"width":1636,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31e2ba854ee84a7599401b75181446db","type":"text","conversion_output":true,"text":"catheterization lab or on the medical floors. At this time all inclusion and exclusion criteria will be assessed.","text_display":" catheterization lab or on the medical floors. At this time all inclusion and exclusion criteria will be assessed.","confidence":1,"confidence_rate":1},{"cnt":[[241,498],[518,498],[518,548],[241,548]],"region":{"top_left_x":240,"top_left_y":498,"width":278,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"917165aeb9c04269866400645e15674b","type":"section_header","conversion_output":false,"children_ids":["3e3f03a02dba4ad5b34da6ba20caa1e3"],"text":"","text_display":""},{"cnt":[[245,503],[513,503],[513,544],[245,544]],"region":{"top_left_x":244,"top_left_y":502,"width":270,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e3f03a02dba4ad5b34da6ba20caa1e3","type":"text","conversion_output":true,"parent_id":"917165aeb9c04269866400645e15674b","text":"Inclusion Criteria","text_display":"\n\n\\section*{Inclusion Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[245,546],[1880,546],[1880,595],[245,595]],"region":{"top_left_x":244,"top_left_y":545,"width":1636,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"619448b0217f408f8f16f09741311089","type":"text","conversion_output":true,"text":"Adult patients \\(\\geq 60\\) years of age who are undergoing CABG with/without valve (aortic and/or mitral)","text_display":"\n\nAdult patients \\(\\geq 60\\) years of age who are undergoing CABG with/without valve (aortic and/or mitral)","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[245,593],[685,593],[685,642],[245,642]],"region":{"top_left_x":244,"top_left_y":592,"width":442,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c11f92b888604b55a9e9734c9e26de79","type":"text","conversion_output":true,"text":"procedure requiring bypass.","text_display":" procedure requiring bypass.","confidence":1,"confidence_rate":1},{"cnt":[[241,670],[531,670],[531,720],[241,720]],"region":{"top_left_x":240,"top_left_y":670,"width":291,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25b447d2d8ac413cac922f30620ac4ca","type":"section_header","conversion_output":false,"children_ids":["0b0f591df1dd4301b5af51425a9b077b"],"text":"","text_display":""},{"cnt":[[245,675],[526,675],[526,715],[245,715]],"region":{"top_left_x":244,"top_left_y":674,"width":283,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b0f591df1dd4301b5af51425a9b077b","type":"text","conversion_output":true,"parent_id":"25b447d2d8ac413cac922f30620ac4ca","text":"Exclusion Criteria","text_display":"\n\n\\section*{Exclusion Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[245,722],[1880,722],[1880,767],[245,767]],"region":{"top_left_x":244,"top_left_y":721,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aea734d991fe4a268e669e08959c21de","type":"text","conversion_output":true,"text":"Patients will be excluded if they had a preoperative LVEF \\(<30 \\%\\) emergent procedure, isolated aortic","text_display":"\n\nPatients will be excluded if they had a preoperative LVEF \\(<30 \\%\\) emergent procedure, isolated aortic","confidence":1,"confidence_rate":1},{"cnt":[[245,767],[1880,767],[1880,814],[245,814]],"region":{"top_left_x":244,"top_left_y":766,"width":1636,"height":49},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06a330a9d842486cae0a1e7de01eff2b","type":"text","conversion_output":true,"text":"surgery, pre-existing cognitive impairment, Parkinson's disease, Alzheimer's disease, prophylactic","text_display":" surgery, pre-existing cognitive impairment, Parkinson's disease, Alzheimer's disease, prophylactic","confidence":1,"confidence_rate":1},{"cnt":[[245,812],[1880,812],[1880,862],[245,862]],"region":{"top_left_x":244,"top_left_y":812,"width":1636,"height":50},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9431f36e60144f269a6adc664e0912c9","type":"text","conversion_output":true,"text":"medications for cognitive decline, active history of drug or alcohol abuse, serum creatinine \\(>2 mg / dL\\), liver","text_display":" medications for cognitive decline, active history of drug or alcohol abuse, serum creatinine \\(>2 mg / dL\\), liver","confidence":1,"confidence_rate":1},{"cnt":[[245,859],[1880,859],[1880,904],[245,904]],"region":{"top_left_x":244,"top_left_y":859,"width":1636,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5994932eba2a47af8f5d9cee5b23be55","type":"text","conversion_output":true,"text":"dysfunction, non-English speaking, seizures in the last three months, emergent procedure or","text_display":" dysfunction, non-English speaking, seizures in the last three months, emergent procedure or","confidence":1,"confidence_rate":1},{"cnt":[[245,902],[952,902],[952,952],[245,952]],"region":{"top_left_x":244,"top_left_y":902,"width":708,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9dc570843ebd46799642dffa702e575d","type":"text","conversion_output":true,"text":"hypersensitivity to study drugs or procedures.","text_display":" hypersensitivity to study drugs or procedures.","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1457,997],[1457,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":996,"width":1213,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdc08f4eff804e4c96b238df71c41ca1","type":"text","conversion_output":true,"text":"Adult patients unqualified or incapable of giving legal consent will be excluded.","text_display":"\n\nAdult patients unqualified or incapable of giving legal consent will be excluded.","confidence":1,"confidence_rate":1},{"cnt":[[241,1074],[556,1074],[556,1124],[241,1124]],"region":{"top_left_x":240,"top_left_y":1074,"width":317,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"925fcdfc314f450e94a049fb95e60d03","type":"section_header","conversion_output":false,"children_ids":["120a9bda4f4c453cbf5ffc84f466c623"],"text":"","text_display":""},{"cnt":[[245,1079],[552,1079],[552,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1078,"width":309,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"120a9bda4f4c453cbf5ffc84f466c623","type":"text","conversion_output":true,"parent_id":"925fcdfc314f450e94a049fb95e60d03","text":"Informed Consent","text_display":"\n\n\\section*{Informed Consent}","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1880,1121],[1880,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1121,"width":1636,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93afc44049ee446eb835a6c766fe3d08","type":"text","conversion_output":true,"text":"Written informed consent will be obtained prior to initiation of any study-specific procedures. Consent will","text_display":"\n\nWritten informed consent will be obtained prior to initiation of any study-specific procedures. Consent will","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1880,1169],[1880,1216],[245,1216]],"region":{"top_left_x":244,"top_left_y":1168,"width":1636,"height":49},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e127bca14abe47e6ae5427ed97871ef5","type":"text","conversion_output":true,"text":"be obtained by one of the participating researchers of the study. At the time of consent, all study procedures","text_display":" be obtained by one of the participating researchers of the study. At the time of consent, all study procedures","confidence":1,"confidence_rate":1},{"cnt":[[245,1216],[1880,1216],[1880,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1216,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62bcd2e298904a1bbed7e8e4bd26b61c","type":"text","conversion_output":true,"text":"will be explained in detail, including the associated risks and benefits. The subjects will have the opportunity","text_display":" will be explained in detail, including the associated risks and benefits. The subjects will have the opportunity","confidence":1,"confidence_rate":1},{"cnt":[[245,1259],[1880,1259],[1880,1308],[245,1308]],"region":{"top_left_x":244,"top_left_y":1258,"width":1636,"height":51},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e116aa2b37104bd68e44acc535258aab","type":"text","conversion_output":true,"text":"to ask any and all questions, and will be reminded that participation is voluntarily. All subjects will be","text_display":" to ask any and all questions, and will be reminded that participation is voluntarily. All subjects will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1306],[1880,1306],[1880,1354],[245,1354]],"region":{"top_left_x":244,"top_left_y":1306,"width":1636,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ad5d30814c641498a78d0124982330f","type":"text","conversion_output":true,"text":"consented with curtains drawn or the door closed, assuring patient privacy. Written informed consent will","text_display":" consented with curtains drawn or the door closed, assuring patient privacy. Written informed consent will","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1880,1354],[1880,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1636,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a30806610d2f44a8a872b5bc429de2cf","type":"text","conversion_output":true,"text":"then be obtained from interested participants. The original signed form will remain with the investigator in","text_display":" then be obtained from interested participants. The original signed form will remain with the investigator in","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1699,1396],[1699,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1456,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f1502e801374eafb18bde7ffedb2696","type":"text","conversion_output":true,"text":"the study file. Copies will be given to the patient and filed in the official medical record as well.","text_display":" the study file. Copies will be given to the patient and filed in the official medical record as well.","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[241,1474],[728,1474],[728,1532],[241,1532]],"region":{"top_left_x":240,"top_left_y":1473,"width":489,"height":59},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dd20f9b9be447a085199979d12f971e","type":"section_header","conversion_output":false,"children_ids":["523104739bfb47ac9238b0a0758f7ee4"],"text":"","text_display":""},{"cnt":[[245,1480],[724,1480],[724,1528],[245,1528]],"region":{"top_left_x":244,"top_left_y":1480,"width":481,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"523104739bfb47ac9238b0a0758f7ee4","type":"text","conversion_output":true,"parent_id":"4dd20f9b9be447a085199979d12f971e","text":"Randomization and Blinding","text_display":"\n\n\\section*{Randomization and Blinding}","confidence":1,"confidence_rate":1},{"cnt":[[245,1525],[1880,1525],[1880,1573],[245,1573]],"region":{"top_left_x":244,"top_left_y":1525,"width":1636,"height":48},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40b41ca2683c4f25a772df89708f7f06","type":"text","conversion_output":true,"text":"After obtaining written informed consent, participants will be randomized to one of four groups by the","text_display":"\n\nAfter obtaining written informed consent, participants will be randomized to one of four groups by the","confidence":1,"confidence_rate":1},{"cnt":[[245,1571],[1880,1571],[1880,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1570,"width":1636,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8f3ba5fc7684ad99ec6fc69a5e167d8","type":"text","conversion_output":true,"text":"research pharmacy using a sequence of computer -generated random numbers. Blocked randomization","text_display":" research pharmacy using a sequence of computer -generated random numbers. Blocked randomization","confidence":0.9990236759185791,"confidence_rate":0.9999902320377446},{"cnt":[[245,1616],[1880,1616],[1880,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1615,"width":1636,"height":51},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31f6591f6c964fafa25cf01a2a7bc90f","type":"text","conversion_output":true,"text":"will be used to assign recruited participants to one of four combinations of analgesics and sedatives in a","text_display":" will be used to assign recruited participants to one of four combinations of analgesics and sedatives in a","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1880,1663],[1880,1710],[245,1710]],"region":{"top_left_x":244,"top_left_y":1662,"width":1636,"height":49},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ae12ed40d3646e883543d2a98bc1f15","type":"text","conversion_output":true,"text":"1:1:1:1 allocation: (1) acetaminophen and dexmedetomidine, (2) acetaminophen and propofol, (3) placebo","text_display":" 1:1:1:1 allocation: (1) acetaminophen and dexmedetomidine, (2) acetaminophen and propofol, (3) placebo","confidence":1,"confidence_rate":1},{"cnt":[[245,1708],[1880,1708],[1880,1755],[245,1755]],"region":{"top_left_x":244,"top_left_y":1708,"width":1636,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d976eab0b134104904a947b5a2d9efc","type":"text","conversion_output":true,"text":"and dexmedetomidine, or (4) placebo and propofol. In order to blind the patient, the care team, and the","text_display":" and dexmedetomidine, or (4) placebo and propofol. In order to blind the patient, the care team, and the","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,1753],[1880,1753],[1880,1800],[245,1800]],"region":{"top_left_x":244,"top_left_y":1753,"width":1636,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"651c94358fe9433393f2e222edae6e83","type":"text","conversion_output":true,"text":"research staff assessing outcomes to the analgesia group, 1 gram of IV acetaminophen and placebo ( \\(0.9 \\%\\)","text_display":" research staff assessing outcomes to the analgesia group, 1 gram of IV acetaminophen and placebo ( \\(0.9 \\%\\)","confidence":0.9917135238647461,"confidence_rate":0.9999243574080382},{"cnt":[[245,1800],[1880,1800],[1880,1848],[245,1848]],"region":{"top_left_x":244,"top_left_y":1800,"width":1636,"height":48},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6f963fc3bce43999c4d23a756539eb9","type":"text","conversion_output":true,"text":"saline) were distributed in equal volume IV bags. Due to the distinct appearance of propofol, there was no","text_display":" saline) were distributed in equal volume IV bags. Due to the distinct appearance of propofol, there was no","confidence":1,"confidence_rate":1},{"cnt":[[245,1848],[720,1848],[720,1893],[245,1893]],"region":{"top_left_x":244,"top_left_y":1847,"width":476,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"118b5f19a6604ce58ebddb1cb0d631e1","type":"text","conversion_output":true,"text":"blinding to the sedation group.","text_display":" blinding to the sedation group.","confidence":1,"confidence_rate":1},{"cnt":[[241,1921],[556,1921],[556,1979],[241,1979]],"region":{"top_left_x":240,"top_left_y":1920,"width":317,"height":59},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4dd41b807ec643fda8cf14d7c6c93876","type":"section_header","conversion_output":false,"children_ids":["10cce0cc4f0b45b6a6bff2182a183f42"],"text":"","text_display":""},{"cnt":[[245,1927],[552,1927],[552,1974],[245,1974]],"region":{"top_left_x":244,"top_left_y":1927,"width":309,"height":48},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10cce0cc4f0b45b6a6bff2182a183f42","type":"text","conversion_output":true,"parent_id":"4dd41b807ec643fda8cf14d7c6c93876","text":"Study Procedures","text_display":"\n\n\\section*{Study Procedures}","confidence":1,"confidence_rate":1},{"cnt":[[245,1970],[406,1970],[406,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1970,"width":163,"height":48},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98a7d9e478264187b7dda9bd5ec1c2d4","type":"section_header","conversion_output":false,"children_ids":["65c75c8d04fc4aaf84845ec3fc7a163a"],"text":"","text_display":""},{"cnt":[[249,1977],[402,1977],[402,2013],[249,2013]],"region":{"top_left_x":249,"top_left_y":1976,"width":153,"height":38},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65c75c8d04fc4aaf84845ec3fc7a163a","type":"text","conversion_output":true,"parent_id":"98a7d9e478264187b7dda9bd5ec1c2d4","text":"Overview","text_display":"\n\n\\section*{Overview}","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[1880,2020],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2019,"width":1636,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f2ff41562724e848f36b79afbf9dd97","type":"text","conversion_output":true,"text":"The proposed study is a randomized, placebo controlled, factorial design, triple blind, clinical trial designed","text_display":"\n\nThe proposed study is a randomized, placebo controlled, factorial design, triple blind, clinical trial designed","confidence":1,"confidence_rate":1},{"cnt":[[245,2065],[1880,2065],[1880,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2064,"width":1636,"height":48},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d63f5126c524534adfd00a1a57198de","type":"text","conversion_output":true,"text":"to evaluate the effect of postoperative IV acetaminophen versus placebo, combined with IV propofol versus","text_display":" to evaluate the effect of postoperative IV acetaminophen versus placebo, combined with IV propofol versus","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[1880,2110],[1880,2159],[245,2159]],"region":{"top_left_x":244,"top_left_y":2109,"width":1636,"height":51},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"844dcc41545c4493a5a6cd7074d01412","type":"text","conversion_output":true,"text":"dexmedetomidine, on postoperative delirium among older patients undergoing cardiac surgery. Patients","text_display":" dexmedetomidine, on postoperative delirium among older patients undergoing cardiac surgery. Patients","confidence":1,"confidence_rate":1},{"cnt":[[245,2157],[1880,2157],[1880,2204],[245,2204]],"region":{"top_left_x":244,"top_left_y":2157,"width":1636,"height":48},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c6d7a6e585842ef8030068cb15dd3fa","type":"text","conversion_output":true,"text":"will be randomized to one of four groups (1) acetaminophen and dexmedetomidine, (2) acetaminophen and","text_display":" will be randomized to one of four groups (1) acetaminophen and dexmedetomidine, (2) acetaminophen and","confidence":0.98681640625,"confidence_rate":0.9998748071886348},{"cnt":[[245,2202],[1880,2202],[1880,2249],[245,2249]],"region":{"top_left_x":244,"top_left_y":2202,"width":1636,"height":48},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfa98830c2774dc8aff7b240b00763d4","type":"text","conversion_output":true,"text":"propofol, (3) placebo and dexmedetomidine, or (4) placebo and propofol. It is possible that the participants","text_display":" propofol, (3) placebo and dexmedetomidine, or (4) placebo and propofol. It is possible that the participants","confidence":0.99267578125,"confidence_rate":0.9999349474918375},{"cnt":[[245,2247],[1880,2247],[1880,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2247,"width":1636,"height":50},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e08b815fc5f44b848e58b5295eb0a63e","type":"text","conversion_output":true,"text":"who receive acetaminophen and dexmedetomidine may benefit from the study as their incidence of delirium","text_display":" who receive acetaminophen and dexmedetomidine may benefit from the study as their incidence of delirium","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[245,2295],[1214,2295],[1214,2340],[245,2340]],"region":{"top_left_x":244,"top_left_y":2294,"width":970,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04acb99e0c194ef599614325e328bf99","type":"text","conversion_output":true,"text":"could possibly be reduced, however we cannot guarantee this.","text_display":" could possibly be reduced, however we cannot guarantee this.","confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a85562b5ea1b4c20a189d23ff84496af","type":"page_info","conversion_output":false,"text":"6","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-07","page":7,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a51a92517ff84159874ef48112b28c27","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"724858fb4dda47d7b5798267c362e953","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,249],[245,249]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7164b4cb3944369a3686e58de8e065a","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[466,249],[466,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":223,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e32d0f0064e24b3b96ac5b2fb89858ec","type":"text","conversion_output":true,"text":"Study Groups","text_display":"\nStudy Groups","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[741,296],[741,337],[245,337]],"region":{"top_left_x":244,"top_left_y":296,"width":498,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e267f4f911e84e46b12eb3f2062d410a","type":"text","conversion_output":true,"text":"The four treatment arms will be:","text_display":"\nThe four treatment arms will be:","confidence":1,"confidence_rate":1},{"cnt":[[370,339],[1033,339],[1033,387],[370,387]],"region":{"top_left_x":369,"top_left_y":339,"width":665,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"025a8f20153f493a8ad8f58df4550a0c","type":"text","conversion_output":true,"text":"1. Acetaminophen and dexmedetomidine","text_display":"\n1. Acetaminophen and dexmedetomidine","confidence":1,"confidence_rate":1},{"cnt":[[370,387],[887,387],[887,432],[370,432]],"region":{"top_left_x":369,"top_left_y":386,"width":519,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10f5ddce32184cc7b3d5045bde159635","type":"text","conversion_output":true,"text":"2. Acetaminophen and propofol","text_display":"\n2. Acetaminophen and propofol","confidence":1,"confidence_rate":1},{"cnt":[[370,434],[920,434],[920,475],[370,475]],"region":{"top_left_x":369,"top_left_y":433,"width":551,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4d7e135355e458d82bd65eac4c3a82c","type":"text","conversion_output":true,"text":"3. Placebo and dexmedetomidine","text_display":"\n3. Placebo and dexmedetomidine","confidence":1,"confidence_rate":1},{"cnt":[[370,477],[771,477],[771,526],[370,526]],"region":{"top_left_x":369,"top_left_y":476,"width":403,"height":51},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54b8259d71aa4714abbce0338346a2ab","type":"text","conversion_output":true,"text":"4. Placebo and propofol","text_display":"\n4. Placebo and propofol","confidence":1,"confidence_rate":1},{"cnt":[[245,571],[1880,571],[1880,617],[245,617]],"region":{"top_left_x":244,"top_left_y":571,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb0da36bca514092966bd2094ae7b216","type":"text","conversion_output":true,"text":"All study medications will be administered intravenously and doses will be weight-based.","text_display":"\n\nAll study medications will be administered intravenously and doses will be weight-based.","confidence":1,"confidence_rate":1},{"cnt":[[245,614],[1880,614],[1880,664],[245,664]],"region":{"top_left_x":244,"top_left_y":614,"width":1636,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5269bb86a1494778be351c0502b1e438","type":"text","conversion_output":true,"text":"Acetaminophen/placebo will be administered on ICU transfer and thereafter every six hours for a total of","text_display":" Acetaminophen/placebo will be administered on ICU transfer and thereafter every six hours for a total of","confidence":1,"confidence_rate":1},{"cnt":[[245,662],[1878,662],[1878,707],[245,707]],"region":{"top_left_x":244,"top_left_y":661,"width":1634,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59a019a686734bbc8f643cdd2fc2bad4","type":"text","conversion_output":true,"text":"eight doses. Volume of the placebo (saline) will match that of IV acetaminophen at \\(100 ml 0.9 \\%\\) sodium","text_display":" eight doses. Volume of the placebo (saline) will match that of IV acetaminophen at \\(100 ml 0.9 \\%\\) sodium","confidence":0.9941489668563008,"confidence_rate":0.9999466539911149},{"cnt":[[245,709],[1880,709],[1880,754],[245,754]],"region":{"top_left_x":244,"top_left_y":708,"width":1636,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"202589ad13f64669ac1aa76492246026","type":"text","conversion_output":true,"text":"chloride. Acetaminophen administration in any form other than the blinded study medication during this","text_display":" chloride. Acetaminophen administration in any form other than the blinded study medication during this","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1880,752],[1880,801],[245,801]],"region":{"top_left_x":244,"top_left_y":751,"width":1636,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ada92f8c14a8493d95e6cdf1dcb70c99","type":"text","conversion_output":true,"text":"time was not allowed. Propofol or dexmedetomidine was started during chest closure and continued for up","text_display":" time was not allowed. Propofol or dexmedetomidine was started during chest closure and continued for up","confidence":1,"confidence_rate":1},{"cnt":[[245,799],[1880,799],[1880,844],[245,844]],"region":{"top_left_x":244,"top_left_y":799,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9377cde8705a4061817da42791b67733","type":"text","conversion_output":true,"text":"to six hours postoperatively or until extubation, whichever occurred first. Participants in the","text_display":" to six hours postoperatively or until extubation, whichever occurred first. Participants in the","confidence":0.99267578125,"confidence_rate":0.9999264909766101},{"cnt":[[245,846],[1880,846],[1880,892],[245,892]],"region":{"top_left_x":244,"top_left_y":846,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94b3825a6186456c8c40c436e9189f19","type":"text","conversion_output":true,"text":"dexmedetomidine groups will get a bolus dose of \\(0.5-1 mcg / kg\\) IV during chest closure, followed by a","text_display":" dexmedetomidine groups will get a bolus dose of \\(0.5-1 mcg / kg\\) IV during chest closure, followed by a","confidence":1,"confidence_rate":1},{"cnt":[[245,894],[1878,894],[1878,939],[245,939]],"region":{"top_left_x":244,"top_left_y":893,"width":1634,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b3a553d849e460a95a7aa2906efd34d","type":"text","conversion_output":true,"text":"maintenance infusion of \\(0.1-1.4 mcg / kg / hour\\). Propofol infusions will be avoided in these participants.","text_display":" maintenance infusion of \\(0.1-1.4 mcg / kg / hour\\). Propofol infusions will be avoided in these participants.","confidence":0.826171875,"confidence_rate":0.9983966443469667},{"cnt":[[245,937],[1880,937],[1880,984],[245,984]],"region":{"top_left_x":244,"top_left_y":936,"width":1636,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"237d245e213145ada2fd7585b99d680d","type":"text","conversion_output":true,"text":"Patients in the propofol groups will receive propofol at a dose of \\(20-100 mcg / kg / min\\) and dexmedetomidine","text_display":" Patients in the propofol groups will receive propofol at a dose of \\(20-100 mcg / kg / min\\) and dexmedetomidine","confidence":1,"confidence_rate":1},{"cnt":[[245,984],[900,984],[900,1029],[245,1029]],"region":{"top_left_x":244,"top_left_y":983,"width":657,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4616135f8fc9495ead780e4adcd4951b","type":"text","conversion_output":true,"text":"infusions will be avoided in these patients.","text_display":" infusions will be avoided in these patients.","confidence":0.998046875,"confidence_rate":0.9999601021258229},{"cnt":[[243,1061],[419,1061],[419,1115],[243,1115]],"region":{"top_left_x":242,"top_left_y":1061,"width":177,"height":55},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70d7ebb9275447389405faed68d89c30","type":"section_header","conversion_output":false,"children_ids":["f1f2554b1e96408687a63a8b21c8d697"],"text":"","text_display":""},{"cnt":[[245,1066],[415,1066],[415,1111],[245,1111]],"region":{"top_left_x":244,"top_left_y":1065,"width":171,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1f2554b1e96408687a63a8b21c8d697","type":"text","conversion_output":true,"parent_id":"70d7ebb9275447389405faed68d89c30","text":"Pharmacy","text_display":"\n\n\\section*{Pharmacy}","confidence":1,"confidence_rate":1},{"cnt":[[245,1111],[1878,1111],[1878,1156],[245,1156]],"region":{"top_left_x":244,"top_left_y":1110,"width":1634,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81bdbfb1f1554f4cbe96e868d0cad513","type":"text","conversion_output":true,"text":"Once a participant is enrolled, the study team will contact the research pharmacy to randomize the subject.","text_display":"\n\nOnce a participant is enrolled, the study team will contact the research pharmacy to randomize the subject.","confidence":1,"confidence_rate":1},{"cnt":[[245,1156],[1880,1156],[1880,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1155,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a36a334024d8477d88125c2f966edea5","type":"text","conversion_output":true,"text":"The research pharmacy at Beth Israel Deaconess Medical Center will be responsible for preparation and","text_display":" The research pharmacy at Beth Israel Deaconess Medical Center will be responsible for preparation and","confidence":1,"confidence_rate":1},{"cnt":[[245,1203],[1878,1203],[1878,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1203,"width":1634,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99dd820716434a7795c338fa5fd10a63","type":"text","conversion_output":true,"text":"distribution of study medications. Study team members will physically deliver the first dose of the","text_display":" distribution of study medications. Study team members will physically deliver the first dose of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1248],[1880,1248],[1880,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1248,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d35e9672d74b48958f8e46f43e220b3f","type":"text","conversion_output":true,"text":"acetaminophen/placebo (saline) medication. Subsequently the research pharmacy will be responsible for","text_display":" acetaminophen/placebo (saline) medication. Subsequently the research pharmacy will be responsible for","confidence":0.9951171875,"confidence_rate":0.999953823968252},{"cnt":[[245,1293],[1880,1293],[1880,1341],[245,1341]],"region":{"top_left_x":244,"top_left_y":1293,"width":1636,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49b39f1f1a8346e688e444507d7655ca","type":"text","conversion_output":true,"text":"delivering the study medication to the ICU. Any unused drug will be returned to the research pharmacy for","text_display":" delivering the study medication to the ICU. Any unused drug will be returned to the research pharmacy for","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[389,1341],[389,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1340,"width":145,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51a3461c6a0343669729d323fb80642e","type":"text","conversion_output":true,"text":"disposal.","text_display":" disposal.","confidence":1,"confidence_rate":1},{"cnt":[[243,1418],[565,1418],[565,1472],[243,1472]],"region":{"top_left_x":242,"top_left_y":1417,"width":324,"height":55},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e26bfa261b134050bcb690b6a9a069d9","type":"section_header","conversion_output":false,"children_ids":["7ad5e1faec764ee38b9b96611d660a71"],"text":"","text_display":""},{"cnt":[[247,1422],[561,1422],[561,1467],[247,1467]],"region":{"top_left_x":247,"top_left_y":1422,"width":314,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ad5e1faec764ee38b9b96611d660a71","type":"text","conversion_output":true,"parent_id":"e26bfa261b134050bcb690b6a9a069d9","text":"Study Assessments","text_display":"\n\n\\section*{Study Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[245,1470],[1878,1470],[1878,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":1634,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6566485945ba4cf2baf91287ed69b4bb","type":"text","conversion_output":true,"text":"The assessments will be completed at specific time points. Once consent is obtained, a trained study team","text_display":"\n\nThe assessments will be completed at specific time points. Once consent is obtained, a trained study team","confidence":1,"confidence_rate":1},{"cnt":[[245,1515],[1878,1515],[1878,1558],[245,1558]],"region":{"top_left_x":244,"top_left_y":1514,"width":1634,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b27498a1a0f47e9bcfa8229c01ef158","type":"text","conversion_output":true,"text":"member blinded to treatment allocation will proceed with a baseline cognitive and delirium assessment.","text_display":" member blinded to treatment allocation will proceed with a baseline cognitive and delirium assessment.","confidence":1,"confidence_rate":1},{"cnt":[[245,1558],[1878,1558],[1878,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1557,"width":1634,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1dd4c2e5e934a6da3bdf74f99a250ae","type":"text","conversion_output":true,"text":"This will include the assessment of cognitive function using the Montreal Cognitive Assessment (MoCA),","text_display":" This will include the assessment of cognitive function using the Montreal Cognitive Assessment (MoCA),","confidence":1,"confidence_rate":1},{"cnt":[[245,1605],[1880,1605],[1880,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1604,"width":1636,"height":49},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74ce0413bc4b4bf09352e5be4ecb6565","type":"text","conversion_output":true,"text":"supplemented with days of the week backwards (DOWB) and months of the year backwards (MOYB) for","text_display":" supplemented with days of the week backwards (DOWB) and months of the year backwards (MOYB) for","confidence":1,"confidence_rate":1},{"cnt":[[245,1650],[1880,1650],[1880,1695],[245,1695]],"region":{"top_left_x":244,"top_left_y":1650,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28cfceb0b00b45a78be3049fb083e021","type":"text","conversion_output":true,"text":"additional attention testing, the Delirium Symptom Interview (DSI) to capture symptoms of delirium and the","text_display":" additional attention testing, the Delirium Symptom Interview (DSI) to capture symptoms of delirium and the","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1880,1697],[1880,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ba9f6fe81354eee9bd273e9c98d37e0","type":"text","conversion_output":true,"text":"Geriatric Depression Scale (GDS) to assess for baseline depression. Using data from the cognitive testing","text_display":" Geriatric Depression Scale (GDS) to assess for baseline depression. Using data from the cognitive testing","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[245,1742],[1880,1742],[1880,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1742,"width":1636,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"788c2b922a1c45cd8ff3f3ddf0e5d22c","type":"text","conversion_output":true,"text":"and DSI, a study team member will complete the Confusion Assessment Method (CAM), which includes a","text_display":" and DSI, a study team member will complete the Confusion Assessment Method (CAM), which includes a","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1880,1788],[1880,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1787,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88752b8e6fd046daac968c1d49509b42","type":"text","conversion_output":true,"text":"diagnosis of delirium using the CAM diagnostic algorithm. This detailed assessment will take no more than","text_display":" diagnosis of delirium using the CAM diagnostic algorithm. This detailed assessment will take no more than","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1880,1835],[1880,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1834,"width":1636,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d9db233839040c3a0efe45cff9d3759","type":"text","conversion_output":true,"text":"20-30 minutes. Every day, a study team member will administer a standard cognitive assessment and the","text_display":" 20-30 minutes. Every day, a study team member will administer a standard cognitive assessment and the","confidence":0.9931640625,"confidence_rate":0.9999352906828807},{"cnt":[[245,1880],[1880,1880],[1880,1927],[245,1927]],"region":{"top_left_x":244,"top_left_y":1879,"width":1636,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e4e47f87bef446badeed9a3856810ec","type":"text","conversion_output":true,"text":"CAM. These daily assessments will take approximately \\(10-15\\) minutes. On the day of discharge, the MoCA","text_display":" CAM. These daily assessments will take approximately \\(10-15\\) minutes. On the day of discharge, the MoCA","confidence":0.9598016738891602,"confidence_rate":0.9996236616077286},{"cnt":[[245,1927],[1880,1927],[1880,1972],[245,1972]],"region":{"top_left_x":244,"top_left_y":1927,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"062a41e481f04a2893e9d72871526037","type":"text","conversion_output":true,"text":"with DOW and MOY, the DSI, and CAM will be completed. (If the discharge assessment was performed in","text_display":" with DOW and MOY, the DSI, and CAM will be completed. (If the discharge assessment was performed in","confidence":1,"confidence_rate":1},{"cnt":[[245,1972],[1878,1972],[1878,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1972,"width":1634,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dbc7f13bee34f9dab811741cf34f7f4","type":"text","conversion_output":true,"text":"anticipation of discharge on a specific day but the discharge was delayed (i.e. logistical reasons, clinical","text_display":" anticipation of discharge on a specific day but the discharge was delayed (i.e. logistical reasons, clinical","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[245,2020],[1880,2020],[1880,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2019,"width":1636,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a713bd23b8447a8a6d37667cbb71e8a","type":"text","conversion_output":true,"text":"reasons), this will not be considered a protocol deviation.) A follow-up assessment will be administered at","text_display":" reasons), this will not be considered a protocol deviation.) A follow-up assessment will be administered at","confidence":1,"confidence_rate":1},{"cnt":[[247,2065],[1880,2065],[1880,2110],[247,2110]],"region":{"top_left_x":247,"top_left_y":2064,"width":1633,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b879b5123c964724858381ce17909444","type":"text","conversion_output":true,"text":"1 month and 1 year post-discharge over the telephone and will include a telephone version of the MoCA","text_display":" 1 month and 1 year post-discharge over the telephone and will include a telephone version of the MoCA","confidence":0.9990236759185791,"confidence_rate":0.9999909555872323},{"cnt":[[245,2110],[1880,2110],[1880,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2109,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1d8799524cc4aa986bd8aff673ec558","type":"text","conversion_output":true,"text":"known as the T-MoCA, DSI, GDS, and CAM. Assessments will be administered and scored by trained","text_display":" known as the T-MoCA, DSI, GDS, and CAM. Assessments will be administered and scored by trained","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[245,2157],[587,2157],[587,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2157,"width":343,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb61c5b06a85487298652f6f263e544d","type":"text","conversion_output":true,"text":"study team members.","text_display":" study team members.","confidence":1,"confidence_rate":1},{"cnt":[[245,2237],[1880,2237],[1880,2279],[245,2279]],"region":{"top_left_x":244,"top_left_y":2236,"width":1636,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf70d1d197264041beb0841e03d0c8f5","type":"text","conversion_output":true,"text":"If daily assessments are negative for three consecutive days (i.e. days \\(5,6 \\& 7\\) ), they will then be completed","text_display":"\n\nIf daily assessments are negative for three consecutive days (i.e. days \\(5,6 \\& 7\\) ), they will then be completed","confidence":0.761360616959359,"confidence_rate":0.997652344882906},{"cnt":[[245,2277],[1880,2277],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88f0194abdb04aeeac31c6ff2ee3dbcd","type":"text","conversion_output":true,"text":"every other day until date of discharge. In addition, these assessments will be done at the patient's convenience","text_display":" every other day until date of discharge. In addition, these assessments will be done at the patient's convenience","confidence":1,"confidence_rate":1},{"cnt":[[243,2316],[1824,2316],[1824,2361],[243,2361]],"region":{"top_left_x":242,"top_left_y":2316,"width":1583,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f29912f850947f4ae9edf319a2cb3e2","type":"text","conversion_output":true,"text":"to ensure ability to finish the evaluations. The table below outlines the assessments at various time points.","text_display":" to ensure ability to finish the evaluations. The table below outlines the assessments at various time points.","confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abc53ce9bdc543a09c945ed2a6d2e379","type":"page_info","conversion_output":false,"text":"7","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-08","page":8,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"198ca6feff9f46988d7f02b55283b0b7","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b768c4c7d43430bab72bdf1495a1d0f","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6286820b9e074cd5b6d4916316e8cc80","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[258,645],[1867,645],[1867,1274],[258,1274]],"region":{"top_left_x":257,"top_left_y":644,"width":1610,"height":631},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"468a9bfe7aeb46709d1194f11f1da4d8","type":"table","conversion_output":true,"children_ids":["ecdfcd5e5a584fb1a57b320f01f36845","e86482fea74c4d0583b3334e577bc8c5","86adfe5514e24427b2fff852813c8e56","89773211bb894d7cae7c92cf33195df6","440ce2f759c2442ebc48ce9bb1974dd3","b42cf67987234513b3f93c4decf85ea8","2cf22ed540014be382aa672b2e77127b","0d35c65425294616a8f0d5e8c4f4396e","c5ac5ba8f6594ebf89faec78a41cbfb3","68dbd92eabdb43c8b1221351f634e770","85d51c8fe6704750955774cdaf5d29f7","78160c0b38be4c1a81cec38f5bc12193","8eb335319024436ea0e512deab7a0242","548650faa90349fb9ab3131cbccd627b","74769a7291704c3b987f0d393f7c0ebb","330a7694764d4f83a98c60a97526e0b0","7d3c1f18d59a4181b706f441541329c3","148173e62800470a92cdcaba32e1c5db","68ec8dc11e7e420ca346a9eef821b5ae","267828d751c0425f9ef37bf519388e3d","cd654dcc70cf49cc907346a39ce02a32","2e26e11789ef4b21a7e662574e3d8bad","d1ea6a8c7f9e4856a70fc7994558c8ee","a4d7a09538824a7884d81068e2776223","5abf756b81c74beab65f48511f335a7c","1d8464f5c9cf449a885bf15d8fa39e39","987f8d95dbec49c8bb90932b58e77eba","7bb18ae117fc43d28c23cfa1b623c9b6","73f1d0e89efd44ddba13876661152e1c","26af13bd78974e43ad691f3ee28ad38a","31e737da743047ecb2386f204e7b3f8c","edd1a2cb56404b628962d3a0d374f6dc","8612c2fa17364dd08de4ba24c7f0af47","5a59f63b2ad54200ad836099a17cd584","9664d44b49fb43449afba462d1fda2f9","195b82a592064f4b90767d15b7c65335","45411517ccb24e3e9f1d881de8be39a3","76dadc9e21964baa9ca7b28337a151c4","c62242241f4740c2856cd9d32fe21267","4e593eb18ecb4d94887ebedc7ddb2272","96352396db074186b3a2674cc23b632c","eeafb00499da4e44ac57932c6f8b9c46","6902566e967e473e9a561e943640bb44","8c41c3f559804c0bba5d6f84b91a2c3a"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline \\multirow[b]{2}{*}{Assessments} & Baseline & Daily & Discharge & 1 month & 1 year \\\\\n\\hline & & & & & \\\\\n\\hline Montreal Cognitive Assessment (MoCA) with Days of the week (DOW) \\& Months of the year (MOY) & X & & X & & \\\\\n\\hline Delirium Symptom Interview (DSI) & X & X & X & X & X \\\\\n\\hline Geriatric Depression Scale (GDS) & X & & & X & X \\\\\n\\hline Confusion Assessment Method (CAM) & X & X & X & X & X \\\\\n\\hline Standard Cognitive Assessment & & X & & & \\\\\n\\hline Telephone Montreal Cognitive Assessment (t-MoCA) with DOW and MOY & & & & X & X \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline \\multirow[b]{2}{*}{Assessments} & Baseline & Daily & Discharge & 1 month & 1 year \\\\\n\\hline & & & & & \\\\\n\\hline Montreal Cognitive Assessment (MoCA) with Days of the week (DOW) \\& Months of the year (MOY) & X & & X & & \\\\\n\\hline Delirium Symptom Interview (DSI) & X & X & X & X & X \\\\\n\\hline Geriatric Depression Scale (GDS) & X & & & X & X \\\\\n\\hline Confusion Assessment Method (CAM) & X & X & X & X & X \\\\\n\\hline Standard Cognitive Assessment & & X & & & \\\\\n\\hline Telephone Montreal Cognitive Assessment (t-MoCA) with DOW and MOY & & & & X & X \\\\\n\\hline\n\\end{tabular}","confidence":1,"confidence_rate":1},{"cnt":[[274,644],[848,644],[848,1274],[274,1274]],"region":{"top_left_x":274,"top_left_y":644,"width":575,"height":631},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecdfcd5e5a584fb1a57b320f01f36845","type":"table_column","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[883,644],[1032,644],[1032,1274],[883,1274]],"region":{"top_left_x":882,"top_left_y":644,"width":151,"height":631},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e86482fea74c4d0583b3334e577bc8c5","type":"table_column","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[1112,644],[1203,644],[1203,1274],[1112,1274]],"region":{"top_left_x":1112,"top_left_y":644,"width":92,"height":631},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86adfe5514e24427b2fff852813c8e56","type":"table_column","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[1273,644],[1444,644],[1444,1274],[1273,1274]],"region":{"top_left_x":1272,"top_left_y":644,"width":172,"height":631},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89773211bb894d7cae7c92cf33195df6","type":"table_column","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[1487,644],[1632,644],[1632,1274],[1487,1274]],"region":{"top_left_x":1486,"top_left_y":644,"width":147,"height":631},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"440ce2f759c2442ebc48ce9bb1974dd3","type":"table_column","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[1701,1274],[1704,644],[1814,644],[1811,1275]],"region":{"top_left_x":1701,"top_left_y":643,"width":113,"height":632},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b42cf67987234513b3f93c4decf85ea8","type":"table_column","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,661],[1864,661],[1864,702],[257,702]],"region":{"top_left_x":257,"top_left_y":661,"width":1607,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2cf22ed540014be382aa672b2e77127b","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,713],[1864,713],[1864,754],[257,754]],"region":{"top_left_x":257,"top_left_y":713,"width":1607,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d35c65425294616a8f0d5e8c4f4396e","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,802],[1866,800],[1866,919],[257,921]],"region":{"top_left_x":256,"top_left_y":799,"width":1611,"height":123},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5ac5ba8f6594ebf89faec78a41cbfb3","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,939],[1864,939],[1864,980],[257,980]],"region":{"top_left_x":257,"top_left_y":938,"width":1607,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68dbd92eabdb43c8b1221351f634e770","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,990],[1864,990],[1864,1032],[257,1032]],"region":{"top_left_x":257,"top_left_y":990,"width":1607,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85d51c8fe6704750955774cdaf5d29f7","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,1049],[1864,1049],[1864,1092],[257,1092]],"region":{"top_left_x":257,"top_left_y":1048,"width":1607,"height":45},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78160c0b38be4c1a81cec38f5bc12193","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,1112],[1864,1112],[1864,1151],[257,1151]],"region":{"top_left_x":257,"top_left_y":1111,"width":1607,"height":40},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8eb335319024436ea0e512deab7a0242","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[257,1155],[1864,1155],[1864,1263],[257,1263]],"region":{"top_left_x":257,"top_left_y":1155,"width":1607,"height":109},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"548650faa90349fb9ab3131cbccd627b","type":"table_row","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"","text_display":""},{"cnt":[[279,661],[844,661],[844,750],[279,750]],"region":{"top_left_x":278,"top_left_y":661,"width":566,"height":90},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74769a7291704c3b987f0d393f7c0ebb","type":"table_spanning_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","children_ids":["f451a74ddacc4743b594688c3a6ed4bf"],"text":"","text_display":"Assessments","cell_row":0,"cell_column":0,"cell_row_span":2,"cell_col_span":1},{"cnt":[[283,713],[489,713],[489,746],[283,746]],"region":{"top_left_x":282,"top_left_y":713,"width":207,"height":33},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f451a74ddacc4743b594688c3a6ed4bf","type":"simple_cell","conversion_output":false,"parent_id":"74769a7291704c3b987f0d393f7c0ebb","text":"Assessments","text_display":"Assessments","cell_row":0,"cell_column":0,"cell_row_span":2,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[894,666],[1026,666],[1026,698],[894,698]],"region":{"top_left_x":893,"top_left_y":665,"width":133,"height":34},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"330a7694764d4f83a98c60a97526e0b0","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Baseline","text_display":"Baseline","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1119,666],[1201,666],[1201,700],[1119,700]],"region":{"top_left_x":1118,"top_left_y":665,"width":84,"height":36},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d3c1f18d59a4181b706f441541329c3","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Daily","text_display":"Daily","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1281,666],[1437,666],[1437,698],[1281,698]],"region":{"top_left_x":1281,"top_left_y":665,"width":157,"height":34},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"148173e62800470a92cdcaba32e1c5db","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Discharge","text_display":"Discharge","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1496,666],[1619,666],[1619,698],[1496,698]],"region":{"top_left_x":1495,"top_left_y":665,"width":125,"height":34},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68ec8dc11e7e420ca346a9eef821b5ae","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"1 month","text_display":"1 month","cell_row":0,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1708,666],[1805,666],[1805,698],[1708,698]],"region":{"top_left_x":1707,"top_left_y":665,"width":99,"height":34},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"267828d751c0425f9ef37bf519388e3d","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"1 year","text_display":"1 year","cell_row":0,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[279,804],[842,804],[842,917],[279,917]],"region":{"top_left_x":278,"top_left_y":804,"width":564,"height":113},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd654dcc70cf49cc907346a39ce02a32","type":"complex_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","children_ids":["9a625621f49f4a95912fa0e62c8a2271","788b22022c7a456cb8e986aee06d0cbe","df06c5a46b574b33bcecd9831a76b94b"],"text":"Montreal Cognitive Assessment (MoCA) with Days of the week (DOW) \\& Months of the year (MOY)","text_display":"Montreal Cognitive Assessment (MoCA) with Days of the week (DOW) \\& Months of the year (MOY)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[283,809],[840,809],[840,843],[283,843]],"region":{"top_left_x":282,"top_left_y":808,"width":558,"height":36},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a625621f49f4a95912fa0e62c8a2271","type":"text","conversion_output":false,"parent_id":"cd654dcc70cf49cc907346a39ce02a32","text":"Montreal Cognitive Assessment (MoCA)","text_display":"Montreal Cognitive Assessment (MoCA)","confidence":1,"confidence_rate":1},{"cnt":[[283,843],[835,843],[835,880],[283,880]],"region":{"top_left_x":282,"top_left_y":843,"width":554,"height":38},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"788b22022c7a456cb8e986aee06d0cbe","type":"text","conversion_output":false,"parent_id":"cd654dcc70cf49cc907346a39ce02a32","text":"with Days of the week (DOW) \\& Months","text_display":" with Days of the week (DOW) \\& Months","confidence":1,"confidence_rate":1},{"cnt":[[283,878],[536,878],[536,915],[283,915]],"region":{"top_left_x":282,"top_left_y":877,"width":255,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df06c5a46b574b33bcecd9831a76b94b","type":"text","conversion_output":false,"parent_id":"cd654dcc70cf49cc907346a39ce02a32","text":"of the year (MOY)","text_display":" of the year (MOY)","confidence":1,"confidence_rate":1},{"cnt":[[939,839],[976,839],[976,874],[939,874]],"region":{"top_left_x":939,"top_left_y":838,"width":37,"height":36},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e26e11789ef4b21a7e662574e3d8bad","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1342,839],[1377,839],[1377,874],[1342,874]],"region":{"top_left_x":1341,"top_left_y":838,"width":36,"height":36},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1ea6a8c7f9e4856a70fc7994558c8ee","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[283,943],[757,943],[757,980],[283,980]],"region":{"top_left_x":282,"top_left_y":942,"width":476,"height":38},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4d7a09538824a7884d81068e2776223","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Delirium Symptom Interview (DSI)","text_display":"Delirium Symptom Interview (DSI)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[939,941],[974,941],[974,971],[939,971]],"region":{"top_left_x":939,"top_left_y":940,"width":35,"height":31},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5abf756b81c74beab65f48511f335a7c","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1145,941],[1175,941],[1175,971],[1145,971]],"region":{"top_left_x":1144,"top_left_y":940,"width":32,"height":31},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d8464f5c9cf449a885bf15d8fa39e39","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":3,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1342,939],[1377,939],[1377,971],[1342,971]],"region":{"top_left_x":1341,"top_left_y":938,"width":36,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"987f8d95dbec49c8bb90932b58e77eba","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":3,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1543,941],[1574,941],[1574,971],[1543,971]],"region":{"top_left_x":1543,"top_left_y":940,"width":31,"height":31},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bb18ae117fc43d28c23cfa1b623c9b6","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":3,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1743,939],[1777,939],[1777,971],[1743,971]],"region":{"top_left_x":1742,"top_left_y":938,"width":36,"height":33},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73f1d0e89efd44ddba13876661152e1c","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":3,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[283,995],[755,995],[755,1032],[283,1032]],"region":{"top_left_x":282,"top_left_y":994,"width":474,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26af13bd78974e43ad691f3ee28ad38a","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Geriatric Depression Scale (GDS)","text_display":"Geriatric Depression Scale (GDS)","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[939,995],[976,995],[976,1025],[939,1025]],"region":{"top_left_x":939,"top_left_y":994,"width":37,"height":32},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31e737da743047ecb2386f204e7b3f8c","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1543,993],[1574,993],[1574,1025],[1543,1025]],"region":{"top_left_x":1543,"top_left_y":992,"width":31,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edd1a2cb56404b628962d3a0d374f6dc","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":4,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1743,993],[1777,993],[1777,1025],[1743,1025]],"region":{"top_left_x":1742,"top_left_y":992,"width":36,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8612c2fa17364dd08de4ba24c7f0af47","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":4,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[283,1053],[818,1053],[818,1090],[283,1090]],"region":{"top_left_x":282,"top_left_y":1053,"width":536,"height":38},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a59f63b2ad54200ad836099a17cd584","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Confusion Assessment Method (CAM)","text_display":"Confusion Assessment Method (CAM)","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[939,1051],[976,1051],[976,1086],[939,1086]],"region":{"top_left_x":939,"top_left_y":1051,"width":37,"height":35},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9664d44b49fb43449afba462d1fda2f9","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1145,1051],[1175,1051],[1175,1086],[1145,1086]],"region":{"top_left_x":1144,"top_left_y":1051,"width":32,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"195b82a592064f4b90767d15b7c65335","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1342,1051],[1377,1051],[1377,1086],[1342,1086]],"region":{"top_left_x":1341,"top_left_y":1051,"width":36,"height":35},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45411517ccb24e3e9f1d881de8be39a3","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":5,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1543,1051],[1574,1051],[1574,1086],[1543,1086]],"region":{"top_left_x":1543,"top_left_y":1051,"width":31,"height":35},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76dadc9e21964baa9ca7b28337a151c4","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":5,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1743,1051],[1777,1051],[1777,1086],[1743,1086]],"region":{"top_left_x":1742,"top_left_y":1051,"width":36,"height":35},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c62242241f4740c2856cd9d32fe21267","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":5,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[283,1114],[731,1114],[731,1149],[283,1149]],"region":{"top_left_x":282,"top_left_y":1113,"width":450,"height":36},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e593eb18ecb4d94887ebedc7ddb2272","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"Standard Cognitive Assessment","text_display":"Standard Cognitive Assessment","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1145,1112],[1175,1112],[1175,1142],[1145,1142]],"region":{"top_left_x":1144,"top_left_y":1111,"width":32,"height":32},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96352396db074186b3a2674cc23b632c","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":6,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[279,1159],[805,1159],[805,1263],[279,1263]],"region":{"top_left_x":278,"top_left_y":1159,"width":527,"height":105},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eeafb00499da4e44ac57932c6f8b9c46","type":"complex_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","children_ids":["c44bc3b82ce047cba6824c1797dd2d48","bbe716bcf8cc4757b94403464d6bba93","7f0aa9704a064754a5e64a294a9950a5"],"text":"Telephone Montreal Cognitive Assessment (t-MoCA) with DOW and MOY","text_display":"Telephone Montreal Cognitive Assessment (t-MoCA) with DOW and MOY","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[281,1159],[703,1159],[703,1194],[281,1194]],"region":{"top_left_x":280,"top_left_y":1159,"width":424,"height":36},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c44bc3b82ce047cba6824c1797dd2d48","type":"text","conversion_output":false,"parent_id":"eeafb00499da4e44ac57932c6f8b9c46","text":"Telephone Montreal Cognitive","text_display":"Telephone Montreal Cognitive","confidence":1,"confidence_rate":1},{"cnt":[[281,1194],[801,1194],[801,1231],[281,1231]],"region":{"top_left_x":280,"top_left_y":1194,"width":521,"height":37},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbe716bcf8cc4757b94403464d6bba93","type":"text","conversion_output":false,"parent_id":"eeafb00499da4e44ac57932c6f8b9c46","text":"Assessment (t-MoCA) with DOW and","text_display":" Assessment (t-MoCA) with DOW and","confidence":1,"confidence_rate":1},{"cnt":[[283,1229],[361,1229],[361,1263],[283,1263]],"region":{"top_left_x":282,"top_left_y":1228,"width":79,"height":36},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f0aa9704a064754a5e64a294a9950a5","type":"text","conversion_output":false,"parent_id":"eeafb00499da4e44ac57932c6f8b9c46","text":"MOY","text_display":" MOY","confidence":1,"confidence_rate":1},{"cnt":[[1543,1194],[1574,1194],[1574,1229],[1543,1229]],"region":{"top_left_x":1543,"top_left_y":1194,"width":31,"height":35},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6902566e967e473e9a561e943640bb44","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":7,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1743,1194],[1777,1194],[1777,1229],[1743,1229]],"region":{"top_left_x":1742,"top_left_y":1194,"width":36,"height":35},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c41c3f559804c0bba5d6f84b91a2c3a","type":"simple_cell","conversion_output":false,"parent_id":"468a9bfe7aeb46709d1194f11f1da4d8","text":"X","text_display":"X","cell_row":7,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[245,1315],[1880,1315],[1880,1358],[245,1358]],"region":{"top_left_x":244,"top_left_y":1314,"width":1636,"height":44},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4997ff4dc8cb44029f26eebadc11c9b7","type":"text","conversion_output":true,"text":"The delirium research assessments will not be provided to the treating clinicians. Treating clinicians will assess","text_display":"\n\nThe delirium research assessments will not be provided to the treating clinicians. Treating clinicians will assess","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1882,1354],[1882,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1353,"width":1639,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"999e16149a4047ee9e7688bef8565c7d","type":"text","conversion_output":true,"text":"and treat delirium as usual, including assessment and correction of reversible causes, behavioral management","text_display":" and treat delirium as usual, including assessment and correction of reversible causes, behavioral management","confidence":1,"confidence_rate":1},{"cnt":[[245,1394],[1850,1394],[1850,1437],[245,1437]],"region":{"top_left_x":244,"top_left_y":1394,"width":1606,"height":44},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93682e55db00440fb44fb37410952ced","type":"text","conversion_output":true,"text":"and use of IV haloperidol for agitation, if needed. Rescue doses of haloperidol will be recorded in the study.","text_display":" and use of IV haloperidol for agitation, if needed. Rescue doses of haloperidol will be recorded in the study.","confidence":0.9990234375,"confidence_rate":0.9999915040391533},{"cnt":[[241,1463],[526,1463],[526,1515],[241,1515]],"region":{"top_left_x":240,"top_left_y":1463,"width":287,"height":52},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"188efa5d955d4c1ab9cfdf639e5d5d66","type":"section_header","conversion_output":false,"children_ids":["8015c5c5ce574733a812fc061950ef4f"],"text":"","text_display":""},{"cnt":[[245,1470],[522,1470],[522,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":279,"height":46},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8015c5c5ce574733a812fc061950ef4f","type":"text","conversion_output":true,"parent_id":"188efa5d955d4c1ab9cfdf639e5d5d66","text":"Blood Acquisition","text_display":"\n\n\\section*{Blood Acquisition}","confidence":1,"confidence_rate":1},{"cnt":[[245,1512],[1880,1512],[1880,1560],[245,1560]],"region":{"top_left_x":244,"top_left_y":1512,"width":1636,"height":48},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d4ca4982d9149d98d78af0cd44fc1e5","type":"text","conversion_output":true,"text":"Blood will be collected at four times points 1) Baseline: at the time of the pre-operative study assessments","text_display":"\n\nBlood will be collected at four times points 1) Baseline: at the time of the pre-operative study assessments","confidence":0.5811870098114014,"confidence_rate":0.9952090118191386},{"cnt":[[245,1560],[1880,1560],[1880,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1559,"width":1636,"height":46},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"704d5e343bc14569b766d82ba28db6c8","type":"text","conversion_output":true,"text":"or on day of surgery; 2) on POD 1 while in the intensive care unit; 3) on POD 2 while in the intensive care","text_display":" or on day of surgery; 2) on POD 1 while in the intensive care unit; 3) on POD 2 while in the intensive care","confidence":1,"confidence_rate":1},{"cnt":[[245,1605],[1880,1605],[1880,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1604,"width":1636,"height":49},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b311ef5f21b4388b60299fa0bdae67d","type":"text","conversion_output":true,"text":"unit; and 4 ) within 48 hours prior to discharge or days \\(8-10\\), at the latest. A total of 80 ccs of blood will be","text_display":" unit; and 4 ) within 48 hours prior to discharge or days \\(8-10\\), at the latest. A total of 80 ccs of blood will be","confidence":0.8009976163182273,"confidence_rate":0.9983203719460763},{"cnt":[[245,1650],[1880,1650],[1880,1697],[245,1697]],"region":{"top_left_x":244,"top_left_y":1650,"width":1636,"height":48},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"632085d6b804497aa7773ec8a3cff55b","type":"text","conversion_output":true,"text":"collected. Blood samples will be collected into sterile vacuum tubes using either a vacutainer or butterfly","text_display":" collected. Blood samples will be collected into sterile vacuum tubes using either a vacutainer or butterfly","confidence":1,"confidence_rate":1},{"cnt":[[245,1697],[1882,1697],[1882,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1639,"height":46},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5df08b3dce4043f5ac42ba2f2a8042ce","type":"text","conversion_output":true,"text":"system, at the preference of the phlebotomist. All samples will be centrifuged. The plasma and buffy coat","text_display":" system, at the preference of the phlebotomist. All samples will be centrifuged. The plasma and buffy coat","confidence":1,"confidence_rate":1},{"cnt":[[245,1742],[1884,1742],[1884,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1742,"width":1641,"height":48},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f3d10af450b4949afa3150bfcb44187","type":"text","conversion_output":true,"text":"will be separated from red blood cells, aliquoted into small samples, labelled and frozen at -80 Celsius for","text_display":" will be separated from red blood cells, aliquoted into small samples, labelled and frozen at -80 Celsius for","confidence":0.98583984375,"confidence_rate":0.9998770647308961},{"cnt":[[245,1788],[1497,1788],[1497,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1254,"height":48},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e57f9b6d7104079836244b1827d7f81","type":"text","conversion_output":true,"text":"future use. Blood samples will be stored in a biomarker bank for further analysis.","text_display":" future use. Blood samples will be stored in a biomarker bank for further analysis.","confidence":1,"confidence_rate":1},{"cnt":[[241,1865],[479,1865],[479,1919],[241,1919]],"region":{"top_left_x":240,"top_left_y":1864,"width":240,"height":55},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"618fca0fe47b4bbf98bc427af052a3b8","type":"section_header","conversion_output":false,"children_ids":["eb3dcacb8da94eed990f7020c2319bd5"],"text":"","text_display":""},{"cnt":[[245,1869],[475,1869],[475,1914],[245,1914]],"region":{"top_left_x":244,"top_left_y":1869,"width":231,"height":46},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb3dcacb8da94eed990f7020c2319bd5","type":"text","conversion_output":true,"parent_id":"618fca0fe47b4bbf98bc427af052a3b8","text":"Blood Storage","text_display":"\n\n\\section*{Blood Storage}","confidence":1,"confidence_rate":1},{"cnt":[[245,1916],[1880,1916],[1880,1962],[245,1962]],"region":{"top_left_x":244,"top_left_y":1916,"width":1636,"height":46},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"366121f58da3497186efca8861d6c10b","type":"text","conversion_output":true,"text":"Using all blood samples from our participants, we will create a bio-repository of genetic material and plasma,","text_display":"\n\nUsing all blood samples from our participants, we will create a bio-repository of genetic material and plasma,","confidence":1,"confidence_rate":1},{"cnt":[[245,1962],[1880,1962],[1880,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1961,"width":1636,"height":46},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7372d2e7b1934154b5a3b78877020e01","type":"text","conversion_output":true,"text":"a resource for future biomarker discovery studies. The banked specimens will be coded and stored in a -","text_display":" a resource for future biomarker discovery studies. The banked specimens will be coded and stored in a ","confidence":0.5927734375,"confidence_rate":0.9951696389490777},{"cnt":[[245,2007],[1880,2007],[1880,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2006,"width":1636,"height":46},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fbc496c2ce14286888adb6b5790f8ec","type":"text","conversion_output":true,"text":"80 Celsius freezer at a BIDMC facility. A list linking study numbers to participants will be kept in a secure","text_display":"80 Celsius freezer at a BIDMC facility. A list linking study numbers to participants will be kept in a secure","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1880,2054],[1880,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2053,"width":1636,"height":47},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c06e84a4efee47e8a140194e6bb2c776","type":"text","conversion_output":true,"text":"computer database. In the future, the frozen plasma or DNA may be shared with other scientists studying","text_display":" computer database. In the future, the frozen plasma or DNA may be shared with other scientists studying","confidence":1,"confidence_rate":1},{"cnt":[[245,2099],[1880,2097],[1880,2144],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":1636,"height":51},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ae57e4e5f994c6882113bc2d9aa4d90","type":"text","conversion_output":true,"text":"a similar relationship between delirium and genetic factors after a formal application procedure and scientific","text_display":" a similar relationship between delirium and genetic factors after a formal application procedure and scientific","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1880,2144],[1880,2191],[245,2191]],"region":{"top_left_x":244,"top_left_y":2144,"width":1636,"height":48},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01b3ecd4451a435fa3d9a58e938a8291","type":"text","conversion_output":true,"text":"review process approved by the IRB. Information including contact information, rationale for studying data","text_display":" review process approved by the IRB. Information including contact information, rationale for studying data","confidence":1,"confidence_rate":1},{"cnt":[[245,2191],[1880,2191],[1880,2237],[245,2237]],"region":{"top_left_x":244,"top_left_y":2191,"width":1636,"height":46},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd3fc956d82d4fa882cd1db8f72d4b47","type":"text","conversion_output":true,"text":"and intended use of data may need to be approved by CCI/IRB prior to sharing data. All such studies will","text_display":" and intended use of data may need to be approved by CCI/IRB prior to sharing data. All such studies will","confidence":1,"confidence_rate":1},{"cnt":[[245,2237],[1880,2237],[1880,2284],[245,2284]],"region":{"top_left_x":244,"top_left_y":2236,"width":1636,"height":48},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2b2afc57de845819d57de1672e57db8","type":"text","conversion_output":true,"text":"be carried out under controlled access and under the close supervision of the study team. In these cases,","text_display":" be carried out under controlled access and under the close supervision of the study team. In these cases,","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,2282],[1882,2282],[1882,2329],[245,2329]],"region":{"top_left_x":244,"top_left_y":2281,"width":1639,"height":48},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f546f03a372b42b3b5c3a552a75da1b3","type":"text","conversion_output":true,"text":"the study investigators will maintain confidentiality of the specimens by maintaining the de-identification of","text_display":" the study investigators will maintain confidentiality of the specimens by maintaining the de-identification of","confidence":1,"confidence_rate":1},{"cnt":[[1852,2363],[1886,2363],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2363,"width":36,"height":39},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57f6bc44dda2455aa54a59cf8a4db072","type":"page_info","conversion_output":false,"text":"8","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-09","page":9,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"167b2d3cebc743d78cbc191e0b64c190","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6504cfc12dca4799b9e9ccbd4dc4b439","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29ed6058dc354c2cabd133240f96f4c5","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1880,249],[1880,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd137f0fff074754ad29cbbaf485a6ea","type":"text","conversion_output":true,"text":"patient information to the other scientists. We plan to store these specimens indefinitely. None of the","text_display":" patient information to the other scientists. We plan to store these specimens indefinitely. None of the","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96f9f3f46e864e56aad3a3491ef10b5c","type":"text","conversion_output":true,"text":"results from these studies will be shared with participants or their family members and none of the genetic","text_display":" results from these studies will be shared with participants or their family members and none of the genetic","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"509f57e141664e11aafaaf3bc5af47b5","type":"text","conversion_output":true,"text":"information obtained will be included in the patient's medical records. All patients approached for","text_display":" information obtained will be included in the patient's medical records. All patients approached for","confidence":1,"confidence_rate":1},{"cnt":[[245,387],[1880,387],[1880,432],[245,432]],"region":{"top_left_x":244,"top_left_y":386,"width":1636,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35c7437d867343828c076fb2cbb9dfde","type":"text","conversion_output":true,"text":"participation in study will also need to agree to participation in blood collection/storage as noted in informed","text_display":" participation in study will also need to agree to participation in blood collection/storage as noted in informed","confidence":1,"confidence_rate":1},{"cnt":[[245,434],[385,434],[385,475],[245,475]],"region":{"top_left_x":244,"top_left_y":433,"width":141,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf8bf105c5d941f08a493db78ca03636","type":"text","conversion_output":true,"text":"consent.","text_display":" consent.","confidence":1,"confidence_rate":1},{"cnt":[[241,511],[415,511],[415,565],[241,565]],"region":{"top_left_x":240,"top_left_y":511,"width":175,"height":55},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc5effa127ba4ddd85e3bf81637d68ea","type":"section_header","conversion_output":false,"children_ids":["5523b62f992445549f3b4a21f9e5e4df"],"text":"","text_display":""},{"cnt":[[245,516],[410,516],[410,561],[245,561]],"region":{"top_left_x":244,"top_left_y":515,"width":167,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5523b62f992445549f3b4a21f9e5e4df","type":"text","conversion_output":true,"parent_id":"dc5effa127ba4ddd85e3bf81637d68ea","text":"Follow Up","text_display":"\n\n\\section*{Follow Up}","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df2b630f23cc417abec3e415c6a8cf04","type":"text","conversion_output":true,"text":"A follow-up assessment will be administered at 1 month and 1 year post-discharge over the telephone and","text_display":"\n\nA follow-up assessment will be administered at 1 month and 1 year post-discharge over the telephone and","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[245,606],[1635,606],[1635,651],[245,651]],"region":{"top_left_x":244,"top_left_y":605,"width":1391,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cace0b22e0ba4e1cad2eaadf5f4ca70f","type":"text","conversion_output":true,"text":"will include a telephone version of the MoCA known as the T-MoCA, DSI, GDS, and CAM.","text_display":" will include a telephone version of the MoCA known as the T-MoCA, DSI, GDS, and CAM.","confidence":1,"confidence_rate":1},{"cnt":[[241,683],[535,683],[535,737],[241,737]],"region":{"top_left_x":240,"top_left_y":683,"width":295,"height":54},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4207c1bf22824f43a81dc2a5996e690f","type":"section_header","conversion_output":false,"children_ids":["5a0c93c741334874a12f44424940d2e5"],"text":"","text_display":""},{"cnt":[[245,688],[531,688],[531,733],[245,733]],"region":{"top_left_x":244,"top_left_y":687,"width":287,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a0c93c741334874a12f44424940d2e5","type":"text","conversion_output":true,"parent_id":"4207c1bf22824f43a81dc2a5996e690f","text":"Study Outcomes","text_display":"\n\n\\section*{Study Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[241,765],[529,765],[529,814],[241,814]],"region":{"top_left_x":240,"top_left_y":764,"width":289,"height":51},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d00c8de1a474b7a911ec43870a773a3","type":"section_header","conversion_output":false,"children_ids":["2fac983499ee42b381da648596a8a1cc"],"text":"","text_display":""},{"cnt":[[245,769],[522,769],[522,810],[245,810]],"region":{"top_left_x":244,"top_left_y":769,"width":279,"height":41},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fac983499ee42b381da648596a8a1cc","type":"text","conversion_output":true,"parent_id":"0d00c8de1a474b7a911ec43870a773a3","text":"Primary Outcome","text_display":"\n\n\\section*{Primary Outcome}","confidence":1,"confidence_rate":1},{"cnt":[[245,814],[1858,814],[1858,862],[245,862]],"region":{"top_left_x":244,"top_left_y":814,"width":1615,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e76f19b750184567a096c0ecdb8c58f8","type":"text","conversion_output":true,"text":"The primary objective of this study was the incidence of in-hospital delirium at any time during a patients'","text_display":"\n\nThe primary objective of this study was the incidence of in-hospital delirium at any time during a patients'","confidence":1,"confidence_rate":1},{"cnt":[[245,859],[455,859],[455,904],[245,904]],"region":{"top_left_x":244,"top_left_y":859,"width":212,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c80b87810599494abbc5c9fc0b80e737","type":"text","conversion_output":true,"text":"hospital stay.","text_display":" hospital stay.","confidence":1,"confidence_rate":1},{"cnt":[[243,937],[593,937],[593,988],[243,988]],"region":{"top_left_x":242,"top_left_y":936,"width":351,"height":53},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e2b2a012afb43e1963f4c6c0644a698","type":"section_header","conversion_output":false,"children_ids":["fc6214cd74104617bd636031b79f8faa"],"text":"","text_display":""},{"cnt":[[245,941],[589,941],[589,984],[245,984]],"region":{"top_left_x":244,"top_left_y":941,"width":345,"height":43},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc6214cd74104617bd636031b79f8faa","type":"text","conversion_output":true,"parent_id":"1e2b2a012afb43e1963f4c6c0644a698","text":"Secondary Outcomes","text_display":"\n\n\\section*{Secondary Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,986],[1824,986],[1824,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":986,"width":1581,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11e2e7e9703a4aeb9bd9ee2723cf0ed9","type":"text","conversion_output":true,"text":"The secondary outcomes included duration of delirium, postoperative neurocognition at discharge, 48-","text_display":"\n\nThe secondary outcomes included duration of delirium, postoperative neurocognition at discharge, 48","confidence":0.9892578125,"confidence_rate":0.9998971452770452},{"cnt":[[245,1031],[1491,1031],[1491,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1031,"width":1248,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18ceec08a51c4a439b8fa1c49afb9e97","type":"text","conversion_output":true,"text":"hour breakthrough analgesic requirements, and ICU and hospital lengths of stay.","text_display":"hour breakthrough analgesic requirements, and ICU and hospital lengths of stay.","confidence":1,"confidence_rate":1},{"cnt":[[241,1109],[494,1109],[494,1158],[241,1158]],"region":{"top_left_x":240,"top_left_y":1108,"width":255,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5626835d2984584ba13bbec532e3b01","type":"section_header","conversion_output":false,"children_ids":["71088bd47826487f858169c68031572e"],"text":"","text_display":""},{"cnt":[[245,1113],[488,1113],[488,1154],[245,1154]],"region":{"top_left_x":244,"top_left_y":1112,"width":244,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71088bd47826487f858169c68031572e","type":"text","conversion_output":true,"parent_id":"c5626835d2984584ba13bbec532e3b01","text":"Data Collection","text_display":"\n\n\\section*{Data Collection}","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[1880,1160],[1880,1203],[245,1203]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa8803b12daf4d1ab9778cc8e592bc45","type":"text","conversion_output":true,"text":"The participant's demographic data such as age, sex, ethnicity, race and body mass index will be recorded.","text_display":"\n\nThe participant's demographic data such as age, sex, ethnicity, race and body mass index will be recorded.","confidence":1,"confidence_rate":1},{"cnt":[[245,1199],[1880,1199],[1880,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1198,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edd9b6447a944a969343460d9c2a2465","type":"text","conversion_output":true,"text":"Patient comorbid conditions, surgery and anesthetic drugs used will be obtained from Society of Thoracic","text_display":" Patient comorbid conditions, surgery and anesthetic drugs used will be obtained from Society of Thoracic","confidence":1,"confidence_rate":1},{"cnt":[[245,1242],[1880,1242],[1880,1283],[245,1283]],"region":{"top_left_x":244,"top_left_y":1241,"width":1636,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cba0e309e0b4f799097f9baef3fc0e8","type":"text","conversion_output":true,"text":"Surgery database and Anesthesia Information Management System, which is a clinical outcomes registry that","text_display":" Surgery database and Anesthesia Information Management System, which is a clinical outcomes registry that","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[1880,1280],[1880,1321],[245,1321]],"region":{"top_left_x":244,"top_left_y":1280,"width":1636,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"811213ff7d2b4c5db2ed05d8b9d84ef2","type":"text","conversion_output":true,"text":"records and assesses the care of adult patients undergoing cardiac procedures at participating hospitals.","text_display":" records and assesses the care of adult patients undergoing cardiac procedures at participating hospitals.","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1880,1319],[1880,1362],[245,1362]],"region":{"top_left_x":244,"top_left_y":1319,"width":1636,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ff4705c53ac4eb8a325f1a876a7d160","type":"text","conversion_output":true,"text":"Pertinent characteristics include: preoperative medications, comorbidities, surgical characteristics, and","text_display":" Pertinent characteristics include: preoperative medications, comorbidities, surgical characteristics, and","confidence":1,"confidence_rate":1},{"cnt":[[245,1360],[1880,1360],[1880,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1359,"width":1636,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27e9f03f8ae943ed820c2c5b844d1f27","type":"text","conversion_output":true,"text":"postoperative outcomes, including 30 day mortality and major adverse events like renal failure during hospital","text_display":" postoperative outcomes, including 30 day mortality and major adverse events like renal failure during hospital","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1880,1401],[1880,1442],[245,1442]],"region":{"top_left_x":244,"top_left_y":1400,"width":1636,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c6043caa5a748ceadf5ee525589eaa2","type":"text","conversion_output":true,"text":"admission. Information on the sedatives and analgesics given within six hours prior to initiation of the cognitive","text_display":" admission. Information on the sedatives and analgesics given within six hours prior to initiation of the cognitive","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15205c9a0bad4d33b8e248d93fc993b4","type":"text","conversion_output":true,"text":"assessment will be recorded, as to determine whether there is an effect on performance. The total opioid","text_display":" assessment will be recorded, as to determine whether there is an effect on performance. The total opioid","confidence":1,"confidence_rate":1},{"cnt":[[245,1480],[1880,1480],[1880,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1480,"width":1636,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e98ea3aee23344bcbda8db7260e0eb07","type":"text","conversion_output":true,"text":"dosage administered during the first 48 hours post operatively, pain scores and patient delirium assessment","text_display":" dosage administered during the first 48 hours post operatively, pain scores and patient delirium assessment","confidence":1,"confidence_rate":1},{"cnt":[[245,1521],[1880,1521],[1880,1562],[245,1562]],"region":{"top_left_x":244,"top_left_y":1521,"width":1636,"height":41},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a210f7b4e824824a3ebcb6796f50654","type":"text","conversion_output":true,"text":"data will be collected using REDCap. REDCap is a web-based application that allows customized data","text_display":" data will be collected using REDCap. REDCap is a web-based application that allows customized data","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1880,1560],[1880,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1559,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44c9e58679d74fdf8a8dd6a5a5003658","type":"text","conversion_output":true,"text":"collection and entry. The study team will build and maintain the case report form electronically. Additionally,","text_display":" collection and entry. The study team will build and maintain the case report form electronically. Additionally,","confidence":1,"confidence_rate":1},{"cnt":[[245,1598],[1880,1598],[1880,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1598,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a336352ba3a40dfb0501007dd4a5db1","type":"text","conversion_output":true,"text":"internal audits will be conducted to ensure data completion and data quality. Data will be kept secure in","text_display":" internal audits will be conducted to ensure data completion and data quality. Data will be kept secure in","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1880,1641],[1880,1682],[245,1682]],"region":{"top_left_x":244,"top_left_y":1641,"width":1636,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c4b689308914711af751005de89082a","type":"text","conversion_output":true,"text":"computers with password protection. All data will be analyzed with modified intention to treat basis, in which","text_display":" computers with password protection. All data will be analyzed with modified intention to treat basis, in which","confidence":1,"confidence_rate":1},{"cnt":[[245,1680],[1446,1680],[1446,1721],[245,1721]],"region":{"top_left_x":244,"top_left_y":1680,"width":1202,"height":41},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3755a3d3d365492c899b956a2b5ee8fa","type":"text","conversion_output":true,"text":"all subjects who receive at least one dose of a study medication will be included.","text_display":" all subjects who receive at least one dose of a study medication will be included.","confidence":1,"confidence_rate":1},{"cnt":[[241,1749],[690,1749],[690,1803],[241,1803]],"region":{"top_left_x":240,"top_left_y":1748,"width":450,"height":55},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00399853eabd46b4b4dfeab39c7a188a","type":"section_header","conversion_output":false,"children_ids":["9de323a7aa7449c688fcd766ea5f8828"],"text":"","text_display":""},{"cnt":[[245,1753],[685,1753],[685,1798],[245,1798]],"region":{"top_left_x":244,"top_left_y":1753,"width":442,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9de323a7aa7449c688fcd766ea5f8828","type":"text","conversion_output":true,"parent_id":"00399853eabd46b4b4dfeab39c7a188a","text":"Data Security and Storage","text_display":"\n\n\\section*{Data Security and Storage}","confidence":1,"confidence_rate":1},{"cnt":[[245,1798],[1880,1798],[1880,1843],[245,1843]],"region":{"top_left_x":244,"top_left_y":1798,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fa1c7fb98df4991bea1153c71e96d18","type":"text","conversion_output":true,"text":"All data will be kept secure in the password-protected BIDMC network servers. The paper format will be","text_display":"\n\nAll data will be kept secure in the password-protected BIDMC network servers. The paper format will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1878,1843],[1878,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1843,"width":1634,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb22da4d678a4fb88b9cf4ac66e17fed","type":"text","conversion_output":true,"text":"stored in locked file cabinets during the study period. Study data will be entered in datasheets and stored","text_display":" stored in locked file cabinets during the study period. Study data will be entered in datasheets and stored","confidence":1,"confidence_rate":1},{"cnt":[[245,1891],[1880,1891],[1880,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1890,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"436a6c3a838a4177b9d51651115cb277","type":"text","conversion_output":true,"text":"on a secure password-protected computer on the BIDMC network. Each patient will be assigned a study-","text_display":" on a secure password-protected computer on the BIDMC network. Each patient will be assigned a study","confidence":1,"confidence_rate":1},{"cnt":[[245,1938],[1880,1938],[1880,1983],[245,1983]],"region":{"top_left_x":244,"top_left_y":1937,"width":1636,"height":47},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"400bf1dbb68143aab19945e05840188a","type":"text","conversion_output":true,"text":"specific ID number. The data will have all HIPAA identifiers removed and a random study number assigned","text_display":"specific ID number. The data will have all HIPAA identifiers removed and a random study number assigned","confidence":1,"confidence_rate":1},{"cnt":[[245,1983],[492,1983],[492,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1983,"width":248,"height":43},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5be91863e18b4edd92633e6471e5bfd9","type":"text","conversion_output":true,"text":"to each patient.","text_display":" to each patient.","confidence":1,"confidence_rate":1},{"cnt":[[241,2058],[535,2058],[535,2112],[241,2112]],"region":{"top_left_x":240,"top_left_y":2058,"width":295,"height":54},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7b04aa5b1f74721a30610ecd97ab0a7","type":"section_header","conversion_output":false,"children_ids":["238b06ded9934230b9ab67f398a1fb59"],"text":"","text_display":""},{"cnt":[[245,2062],[531,2062],[531,2108],[245,2108]],"region":{"top_left_x":244,"top_left_y":2062,"width":287,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"238b06ded9934230b9ab67f398a1fb59","type":"text","conversion_output":true,"parent_id":"c7b04aa5b1f74721a30610ecd97ab0a7","text":"Safety Reporting","text_display":"\n\n\\section*{Safety Reporting}","confidence":1,"confidence_rate":1},{"cnt":[[245,2110],[1843,2110],[1843,2155],[245,2155]],"region":{"top_left_x":244,"top_left_y":2109,"width":1600,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb2fbc8c75184b02a18e779f888ec5cd","type":"text","conversion_output":true,"text":"Our patient population is by definition undergoing high risk surgery and is critically ill. It is expected that","text_display":"\n\nOur patient population is by definition undergoing high risk surgery and is critically ill. It is expected that","confidence":1,"confidence_rate":1},{"cnt":[[245,2155],[1846,2155],[1846,2202],[245,2202]],"region":{"top_left_x":244,"top_left_y":2154,"width":1602,"height":49},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e653638956754f2bb3532f8f7e391ff4","type":"text","conversion_output":true,"text":"they will have a number of unrelated adverse health events during the course of their hospital stay. The","text_display":" they will have a number of unrelated adverse health events during the course of their hospital stay. The","confidence":1,"confidence_rate":1},{"cnt":[[245,2200],[1858,2200],[1858,2247],[245,2247]],"region":{"top_left_x":244,"top_left_y":2200,"width":1615,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02a1364d54d1496582079384d2243a43","type":"text","conversion_output":true,"text":"potential adverse effects such as the number of episodes of hypotension (predefined as \\(<90 mm\\) systolic","text_display":" potential adverse effects such as the number of episodes of hypotension (predefined as \\(<90 mm\\) systolic","confidence":0.8837890625,"confidence_rate":0.9988976003938604},{"cnt":[[245,2245],[1841,2245],[1841,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2245,"width":1598,"height":48},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a221cf41a47a4b7aa12db1aa4b9d6e57","type":"text","conversion_output":true,"text":"for 5 minutes or more), and bradycardia (predefined as <40 beats per minute), will be collected from the","text_display":" for 5 minutes or more), and bradycardia (predefined as <40 beats per minute), will be collected from the","confidence":0.78466796875,"confidence_rate":0.9978372116649477},{"cnt":[[245,2295],[428,2295],[428,2331],[245,2331]],"region":{"top_left_x":244,"top_left_y":2294,"width":184,"height":38},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f0892381ce84faf99fda7a5b97bc021","type":"text","conversion_output":true,"text":"ICU charts.","text_display":" ICU charts.","confidence":1,"confidence_rate":1},{"cnt":[[1852,2365],[1886,2365],[1886,2402],[1852,2402]],"region":{"top_left_x":1851,"top_left_y":2365,"width":36,"height":37},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f10029108b64749997d75a3617eb834","type":"page_info","conversion_output":false,"text":"9","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-10","page":10,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31ede58a24144a0588b72907db1fb175","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1266a9be6e8e44d0bd3f0497fc8cf40a","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6fcdfb8a1ed4ca5bc5345ab8309c283","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1549,249],[1549,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":1306,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b169e887d714608b56e822d1696d107","type":"text","conversion_output":true,"text":"Therefore, we will limit the scope of our AE monitoring and reporting to the following:","text_display":"\nTherefore, we will limit the scope of our AE monitoring and reporting to the following:","confidence":0.9975602623308077,"confidence_rate":0.9999734490624963},{"cnt":[[305,296],[1830,296],[1830,342],[305,342]],"region":{"top_left_x":305,"top_left_y":296,"width":1526,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a4aaab128a946f9bcec34191c53713a","type":"text","conversion_output":true,"text":"- All Serious Adverse Events, including an unexpected death, believed to be related to the study","text_display":"\n- All Serious Adverse Events, including an unexpected death, believed to be related to the study","confidence":1,"confidence_rate":1},{"cnt":[[305,344],[1777,344],[1777,389],[305,389]],"region":{"top_left_x":305,"top_left_y":343,"width":1472,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b09f4db150cf406784391b2639f2099c","type":"text","conversion_output":true,"text":"- Unexpected, non-serious Adverse Events believed to be possibly or probably related to the","text_display":"\n- Unexpected, non-serious Adverse Events believed to be possibly or probably related to the","confidence":1,"confidence_rate":1},{"cnt":[[370,389],[561,389],[561,428],[370,428]],"region":{"top_left_x":369,"top_left_y":388,"width":192,"height":40},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66482e319d9c4a68bba18fd7df0be7e9","type":"text","conversion_output":true,"text":"intervention","text_display":" intervention","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1828,468],[1828,513],[245,513]],"region":{"top_left_x":244,"top_left_y":468,"width":1585,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30d2965667644107bcc0a38644714f0f","type":"text","conversion_output":true,"text":"Evidence for adverse events will be assessed daily during the hospital stay, for a maximum of 10 days.","text_display":"\n\nEvidence for adverse events will be assessed daily during the hospital stay, for a maximum of 10 days.","confidence":1,"confidence_rate":1},{"cnt":[[241,546],[574,546],[574,597],[241,597]],"region":{"top_left_x":240,"top_left_y":545,"width":334,"height":53},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efec4b68119147018a80e954963cacfd","type":"section_header","conversion_output":false,"children_ids":["020805dc63f64f1caa395a73f1a3bc91"],"text":"","text_display":""},{"cnt":[[245,550],[569,550],[569,591],[245,591]],"region":{"top_left_x":244,"top_left_y":550,"width":326,"height":41},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"020805dc63f64f1caa395a73f1a3bc91","type":"text","conversion_output":true,"parent_id":"efec4b68119147018a80e954963cacfd","text":"Statistical Analysis","text_display":"\n\n\\section*{Statistical Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[245,595],[1775,595],[1775,638],[245,638]],"region":{"top_left_x":244,"top_left_y":595,"width":1531,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d064a32c2acd45dfaa2371bc8b760213","type":"text","conversion_output":true,"text":"Please refer to the Statistical Analysis Plan (SAP) for details of the power calculation and analyses.","text_display":"\n\nPlease refer to the Statistical Analysis Plan (SAP) for details of the power calculation and analyses.","confidence":1,"confidence_rate":1},{"cnt":[[241,670],[634,670],[634,724],[241,724]],"region":{"top_left_x":240,"top_left_y":670,"width":394,"height":55},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f29204995b84e96a6e463afac70fceb","type":"section_header","conversion_output":false,"children_ids":["01225946525844ffacb605571bf2bb81"],"text":"","text_display":""},{"cnt":[[245,675],[629,675],[629,720],[245,720]],"region":{"top_left_x":244,"top_left_y":674,"width":386,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01225946525844ffacb605571bf2bb81","type":"text","conversion_output":true,"parent_id":"2f29204995b84e96a6e463afac70fceb","text":"Benefits to the Subject","text_display":"\n\n\\section*{Benefits to the Subject}","confidence":1,"confidence_rate":1},{"cnt":[[245,722],[1882,722],[1882,767],[245,767]],"region":{"top_left_x":244,"top_left_y":721,"width":1639,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cc7490066e14f888172b4124094a30a","type":"text","conversion_output":true,"text":"There is a possible benefit to those enrolled in the dexmedetomidine and acetaminophen group, as their","text_display":"\n\nThere is a possible benefit to those enrolled in the dexmedetomidine and acetaminophen group, as their","confidence":1,"confidence_rate":1},{"cnt":[[245,769],[1880,769],[1880,814],[245,814]],"region":{"top_left_x":244,"top_left_y":769,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4b6845cafdf4afebf732751bfeec7d3","type":"text","conversion_output":true,"text":"incidence of delirium can possibly be reduced, however we cannot guarantee this. Society as a whole will","text_display":" incidence of delirium can possibly be reduced, however we cannot guarantee this. Society as a whole will","confidence":1,"confidence_rate":1},{"cnt":[[245,814],[1338,814],[1338,862],[245,862]],"region":{"top_left_x":244,"top_left_y":814,"width":1095,"height":48},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2d4ae8e7fdc4223989d717d743f4e58","type":"text","conversion_output":true,"text":"benefit in the future as a result of knowledge gained from the research.","text_display":" benefit in the future as a result of knowledge gained from the research.","confidence":1,"confidence_rate":1},{"cnt":[[241,889],[591,889],[591,943],[241,943]],"region":{"top_left_x":240,"top_left_y":889,"width":351,"height":55},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e122ebf3bfdf4ee7a1642129eae9a23d","type":"section_header","conversion_output":false,"children_ids":["bbe5a070cb83472faadccc61fd699faa"],"text":"","text_display":""},{"cnt":[[245,894],[587,894],[587,939],[245,939]],"region":{"top_left_x":244,"top_left_y":893,"width":343,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbe5a070cb83472faadccc61fd699faa","type":"text","conversion_output":true,"parent_id":"e122ebf3bfdf4ee7a1642129eae9a23d","text":"Risks to the Subject","text_display":"\n\n\\section*{Risks to the Subject}","confidence":1,"confidence_rate":1},{"cnt":[[241,971],[621,971],[621,1025],[241,1025]],"region":{"top_left_x":240,"top_left_y":971,"width":381,"height":54},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4108baecb3e42fc8db3d12091ace157","type":"section_header","conversion_output":false,"children_ids":["854412fd4f544565860500a017e6e8e6"],"text":"","text_display":""},{"cnt":[[245,975],[612,975],[612,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":975,"width":369,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"854412fd4f544565860500a017e6e8e6","type":"text","conversion_output":true,"parent_id":"f4108baecb3e42fc8db3d12091ace157","text":"Risk of the Drugs Used","text_display":"\n\n\\section*{Risk of the Drugs Used}","confidence":1,"confidence_rate":1},{"cnt":[[245,1023],[1878,1023],[1878,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1022,"width":1634,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0504e2be335e4084ae902288e0a7c848","type":"text","conversion_output":true,"text":"The drugs dexmedetomidine and acetaminophen are FDA approved for sedation and analgesic purposes.","text_display":"\n\nThe drugs dexmedetomidine and acetaminophen are FDA approved for sedation and analgesic purposes.","confidence":1,"confidence_rate":1},{"cnt":[[245,1066],[1880,1066],[1880,1111],[245,1111]],"region":{"top_left_x":244,"top_left_y":1065,"width":1636,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"046b0e5662894694a89cd2b8f0f365b4","type":"text","conversion_output":true,"text":"Bradycardia and hypotension are less common side effects with dexmedetomidine and in an intensively","text_display":" Bradycardia and hypotension are less common side effects with dexmedetomidine and in an intensively","confidence":1,"confidence_rate":1},{"cnt":[[245,1113],[1878,1113],[1878,1158],[245,1158]],"region":{"top_left_x":244,"top_left_y":1112,"width":1634,"height":47},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"474cabe427e84b6fa5b3c954dc7f803c","type":"text","conversion_output":true,"text":"monitored setting of cardiac surgical ICU, the risks of bradycardia and hypotension can be managed","text_display":" monitored setting of cardiac surgical ICU, the risks of bradycardia and hypotension can be managed","confidence":1,"confidence_rate":1},{"cnt":[[245,1160],[1880,1160],[1880,1205],[245,1205]],"region":{"top_left_x":244,"top_left_y":1160,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97b0f3cb67e34968919164a67ad4f0fd","type":"text","conversion_output":true,"text":"effectively. Liver dysfunction is a rare side effect associated with IV acetaminophen. However, the drug is","text_display":" effectively. Liver dysfunction is a rare side effect associated with IV acetaminophen. However, the drug is","confidence":1,"confidence_rate":1},{"cnt":[[245,1205],[1876,1205],[1876,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1205,"width":1632,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef19ae8f32144aab976bc6433407201b","type":"text","conversion_output":true,"text":"commonly used already in the perioperative setting routinely as the benefits seem to outweigh the risks.","text_display":" commonly used already in the perioperative setting routinely as the benefits seem to outweigh the risks.","confidence":1,"confidence_rate":1},{"cnt":[[245,1250],[1497,1250],[1497,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1250,"width":1254,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4709e014fc3b48628aff29a23911d549","type":"text","conversion_output":true,"text":"No routine monitoring is done for liver dysfunction in the current standard of care.","text_display":" No routine monitoring is done for liver dysfunction in the current standard of care.","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[241,1328],[769,1328],[769,1377],[241,1377]],"region":{"top_left_x":240,"top_left_y":1327,"width":530,"height":51},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43a8143273ce4432a5369785ba51b20e","type":"section_header","conversion_output":false,"children_ids":["b6a48b3844154ebf9536dcf037f28f0e"],"text":"","text_display":""},{"cnt":[[245,1332],[765,1332],[765,1371],[245,1371]],"region":{"top_left_x":244,"top_left_y":1332,"width":521,"height":39},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6a48b3844154ebf9536dcf037f28f0e","type":"text","conversion_output":true,"parent_id":"43a8143273ce4432a5369785ba51b20e","text":"Risk Associated with Blood Draw","text_display":"\n\n\\section*{Risk Associated with Blood Draw}","confidence":1,"confidence_rate":1},{"cnt":[[245,1377],[1878,1377],[1878,1422],[245,1422]],"region":{"top_left_x":244,"top_left_y":1377,"width":1634,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a61198b60a5447d4bb6c434b89cc8a79","type":"text","conversion_output":true,"text":"There is a small risk of phlebotomy to obtain serum for the serum biomarker assays at four time points","text_display":"\n\nThere is a small risk of phlebotomy to obtain serum for the serum biomarker assays at four time points","confidence":1,"confidence_rate":1},{"cnt":[[245,1422],[1880,1422],[1880,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1422,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09358cc9a4644b78b4bc536284368ef6","type":"text","conversion_output":true,"text":"during the study. Wherever possible, the serum collection will be obtained at the same time as phlebotomy","text_display":" during the study. Wherever possible, the serum collection will be obtained at the same time as phlebotomy","confidence":0.99658203125,"confidence_rate":0.9999688748175845},{"cnt":[[245,1470],[1880,1470],[1880,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1469,"width":1636,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6c314d574e84085acf4e0c77456beb4","type":"text","conversion_output":true,"text":"and other labs for routine clinical laboratory work, thereby eliminating an additional risk imposed by a","text_display":" and other labs for routine clinical laboratory work, thereby eliminating an additional risk imposed by a","confidence":1,"confidence_rate":1},{"cnt":[[245,1517],[1880,1517],[1880,1560],[245,1560]],"region":{"top_left_x":244,"top_left_y":1516,"width":1636,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ec55ce3cf3d4ce1a8a5a5aec6c26c0e","type":"text","conversion_output":true,"text":"separate phlebotomy for study purposes. However, in rare cases such as at the time of discharge, patients","text_display":" separate phlebotomy for study purposes. However, in rare cases such as at the time of discharge, patients","confidence":0.99560546875,"confidence_rate":0.9999599624780234},{"cnt":[[245,1560],[1880,1560],[1880,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1559,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aee9e1b04fdb4f03af35556db0fcd724","type":"text","conversion_output":true,"text":"may require a separate lab draw. The risks of the phlebotomy procedure itself are minimal and are primarily","text_display":" may require a separate lab draw. The risks of the phlebotomy procedure itself are minimal and are primarily","confidence":1,"confidence_rate":1},{"cnt":[[245,1607],[1880,1607],[1880,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1607,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"37eb22dbd06c428393dd41d773ee7d0f","type":"text","conversion_output":true,"text":"related to pain or bruising at the needle puncture site. Since the amount of blood required at each time","text_display":" related to pain or bruising at the needle puncture site. Since the amount of blood required at each time","confidence":1,"confidence_rate":1},{"cnt":[[245,1652],[1878,1652],[1878,1697],[245,1697]],"region":{"top_left_x":244,"top_left_y":1652,"width":1634,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ffe44ce1c024d95b72fcc416de7baa5","type":"text","conversion_output":true,"text":"point is small the risks from anemia or blood loss are negligible. The blood draws will total only 80 cc's","text_display":" point is small the risks from anemia or blood loss are negligible. The blood draws will total only 80 cc's","confidence":0.99609375,"confidence_rate":0.9999656681391664},{"cnt":[[245,1697],[1250,1697],[1250,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1007,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea4a7a8e555845e78b89d95524a0fbc7","type":"text","conversion_output":true,"text":"over a maximum of four weeks, which is considered minimal risk.","text_display":" over a maximum of four weeks, which is considered minimal risk.","confidence":1,"confidence_rate":1},{"cnt":[[241,1775],[754,1775],[754,1828],[241,1828]],"region":{"top_left_x":240,"top_left_y":1774,"width":515,"height":55},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb78312d2987404091773c0bd8fa5fee","type":"section_header","conversion_output":false,"children_ids":["31ca51c450584d3ca8c51c737bc62318"],"text":"","text_display":""},{"cnt":[[245,1779],[750,1779],[750,1824],[245,1824]],"region":{"top_left_x":244,"top_left_y":1778,"width":506,"height":47},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31ca51c450584d3ca8c51c737bc62318","type":"text","conversion_output":true,"parent_id":"cb78312d2987404091773c0bd8fa5fee","text":"Risk of Breach of Confidentiality","text_display":"\n\n\\section*{Risk of Breach of Confidentiality}","confidence":1,"confidence_rate":1},{"cnt":[[245,1826],[1880,1826],[1880,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1826,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9cd19af7ff84b848e3740a36161b3e8","type":"text","conversion_output":true,"text":"Patients will be referred to by a study number, and records will be password protected on BIDMC network","text_display":"\n\nPatients will be referred to by a study number, and records will be password protected on BIDMC network","confidence":1,"confidence_rate":1},{"cnt":[[245,1869],[1880,1869],[1880,1916],[245,1916]],"region":{"top_left_x":244,"top_left_y":1869,"width":1636,"height":48},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94c3d1cadd3444e49e9ecd68a0851383","type":"text","conversion_output":true,"text":"servers. No identifiable data will be shared with the funding agency, or across institutions. The information","text_display":" servers. No identifiable data will be shared with the funding agency, or across institutions. The information","confidence":1,"confidence_rate":1},{"cnt":[[245,1916],[1880,1916],[1880,1962],[245,1962]],"region":{"top_left_x":244,"top_left_y":1916,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94e6361db08441de96831d8bdbc527bc","type":"text","conversion_output":true,"text":"that we collect from this research project will be kept confidential. All information will be stored in a HIPAA","text_display":" that we collect from this research project will be kept confidential. All information will be stored in a HIPAA","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,1964],[563,1964],[563,2009],[245,2009]],"region":{"top_left_x":244,"top_left_y":1963,"width":319,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b9e6be66551442295c47520e1d307c9","type":"text","conversion_output":true,"text":"compliant database.","text_display":" compliant database.","confidence":1,"confidence_rate":1},{"cnt":[[241,2041],[535,2041],[535,2086],[241,2086]],"region":{"top_left_x":240,"top_left_y":2041,"width":295,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90ecfc7657724623a8044a98062bed5c","type":"section_header","conversion_output":false,"children_ids":["3e82ea3e38c240aa93e3e3f3ef227197"],"text":"","text_display":""},{"cnt":[[245,2045],[531,2045],[531,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2045,"width":287,"height":37},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e82ea3e38c240aa93e3e3f3ef227197","type":"text","conversion_output":true,"parent_id":"90ecfc7657724623a8044a98062bed5c","text":"Risk/Benefit Ratio","text_display":"\n\n\\section*{Risk/Benefit Ratio}","confidence":1,"confidence_rate":1},{"cnt":[[245,2088],[1878,2088],[1878,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2088,"width":1634,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7926763ddad2447195d811fa12cfeceb","type":"text","conversion_output":true,"text":"The drugs used for this study are approved by the FDA for sedation and analgesic purposes. When","text_display":"\n\nThe drugs used for this study are approved by the FDA for sedation and analgesic purposes. When","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1876,2136],[1876,2181],[245,2181]],"region":{"top_left_x":244,"top_left_y":2135,"width":1632,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48cb77e1996741b393fd007b07670eb5","type":"text","conversion_output":true,"text":"monitored in the intensive care setting, the risks of lower blood pressures or heart rates are far too small","text_display":" monitored in the intensive care setting, the risks of lower blood pressures or heart rates are far too small","confidence":1,"confidence_rate":1},{"cnt":[[245,2183],[1377,2183],[1377,2228],[245,2228]],"region":{"top_left_x":244,"top_left_y":2182,"width":1134,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8be037be557d4387bea0bbb93bf9f96e","type":"text","conversion_output":true,"text":"compared to the benefits of decreased delirium following cardiac surgery.","text_display":" compared to the benefits of decreased delirium following cardiac surgery.","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"306020c8d8234d0e947aaf0e1a026f0e","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-11","page":11,"lines":[{"cnt":[[245,125],[1721,125],[1721,170],[245,170]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bab49f64be6548dd95698ad3a98ea5b2","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"613b49a1ad6a4b6c82795e202a4c073e","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a02931b281dd494997f96780070c1c1d","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,245],[475,245],[475,294],[241,294]],"region":{"top_left_x":240,"top_left_y":244,"width":235,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d9cc02ecdcd4c9f93ce86e9e4978fb3","type":"section_header","conversion_output":false,"children_ids":["d027307c45014dac95f37c60d5c7df43"],"text":"","text_display":""},{"cnt":[[245,249],[466,249],[466,290],[245,290]],"region":{"top_left_x":244,"top_left_y":249,"width":223,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d027307c45014dac95f37c60d5c7df43","type":"text","conversion_output":true,"parent_id":"2d9cc02ecdcd4c9f93ce86e9e4978fb3","text":"Inducements","text_display":"\n\n\\section*{Inducements}","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"581dd8a60b2e483c8ab78ca4ea696d16","type":"text","conversion_output":true,"text":"No inducements will be offered. Neither patients nor healthcare providers will be paid as part of their","text_display":"\n\nNo inducements will be offered. Neither patients nor healthcare providers will be paid as part of their","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[638,339],[638,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":395,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dde4f64b7c74910975abf2959cbde03","type":"text","conversion_output":true,"text":"participation in the study.","text_display":" participation in the study.","confidence":1,"confidence_rate":1},{"cnt":[[241,419],[651,419],[651,471],[241,471]],"region":{"top_left_x":240,"top_left_y":418,"width":411,"height":53},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9107d316158427c877131caeeda47fe","type":"section_header","conversion_output":false,"children_ids":["6359fcf337624e09a6624e800334d956"],"text":"","text_display":""},{"cnt":[[245,425],[647,425],[647,466],[245,466]],"region":{"top_left_x":244,"top_left_y":425,"width":403,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6359fcf337624e09a6624e800334d956","type":"text","conversion_output":true,"parent_id":"f9107d316158427c877131caeeda47fe","text":"Participant Withdrawals","text_display":"\n\n\\section*{Participant Withdrawals}","confidence":1,"confidence_rate":1},{"cnt":[[245,468],[1880,468],[1880,513],[245,513]],"region":{"top_left_x":244,"top_left_y":468,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0772269b00064c85b90bcda14c36fec8","type":"text","conversion_output":true,"text":"Throughout the study participants will be reminded that participation is entirely voluntary and that they have","text_display":"\n\nThroughout the study participants will be reminded that participation is entirely voluntary and that they have","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1021,511],[1021,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":777,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"afd85411cbbd4aa7b7c0fa171f85b150","type":"text","conversion_output":true,"text":"the option to withdraw at any time, for any reason.","text_display":" the option to withdraw at any time, for any reason.","confidence":1,"confidence_rate":1},{"cnt":[[241,589],[565,589],[565,642],[241,642]],"region":{"top_left_x":240,"top_left_y":588,"width":326,"height":55},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fb4166d184b4f329f8b56dd26dc3743","type":"section_header","conversion_output":false,"children_ids":["39a9820fe0044913a4254e6086a47e35"],"text":"","text_display":""},{"cnt":[[245,593],[561,593],[561,638],[245,638]],"region":{"top_left_x":244,"top_left_y":592,"width":317,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39a9820fe0044913a4254e6086a47e35","type":"text","conversion_output":true,"parent_id":"7fb4166d184b4f329f8b56dd26dc3743","text":"Subject Protection","text_display":"\n\n\\section*{Subject Protection}","confidence":1,"confidence_rate":1},{"cnt":[[245,640],[1880,640],[1880,685],[245,685]],"region":{"top_left_x":244,"top_left_y":640,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47bf88a5b17a4c7bb8e4d945999a01ea","type":"text","conversion_output":true,"text":"Patients will be contacted directly for this study. The informed consent will be explained and obtained in a","text_display":"\n\nPatients will be contacted directly for this study. The informed consent will be explained and obtained in a","confidence":1,"confidence_rate":1},{"cnt":[[245,688],[1880,688],[1880,733],[245,733]],"region":{"top_left_x":244,"top_left_y":687,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"def3f2d9483149c9a66f074c7a0e23c1","type":"text","conversion_output":true,"text":"secure and private location such as the preadmission testing clinic, cardiac catheterization holding areas,","text_display":" secure and private location such as the preadmission testing clinic, cardiac catheterization holding areas,","confidence":1,"confidence_rate":1},{"cnt":[[245,733],[1880,733],[1880,778],[245,778]],"region":{"top_left_x":244,"top_left_y":732,"width":1636,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7d0044871ce4067805a327403b51f43","type":"text","conversion_output":true,"text":"cardiac surgery clinic, and/or in the pre-operative holding area. Patients will be informed that their decision","text_display":" cardiac surgery clinic, and/or in the pre-operative holding area. Patients will be informed that their decision","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1880,778],[1880,825],[245,825]],"region":{"top_left_x":244,"top_left_y":777,"width":1636,"height":48},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff8881ec8a714167957628e67add07e5","type":"text","conversion_output":true,"text":"to participate or not to participate will in no way affect their relationship with their health care provider.","text_display":" to participate or not to participate will in no way affect their relationship with their health care provider.","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1880,825],[1880,870],[245,870]],"region":{"top_left_x":244,"top_left_y":825,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fcd17af153c4d679b6b21963247a114","type":"text","conversion_output":true,"text":"Furthermore they will still receive all information about their analgesic management, as is the standard of","text_display":" Furthermore they will still receive all information about their analgesic management, as is the standard of","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1534,868],[1534,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1290,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4c15e0e0bf74d448ca8d77a954aee04","type":"text","conversion_output":true,"text":"care. Patients will also have the ability to discontinue their participation at any time.","text_display":" care. Patients will also have the ability to discontinue their participation at any time.","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b72f71932ea04a8f914d54deedd21eb3","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-12","page":12,"lines":[{"cnt":[[247,125],[1721,125],[1721,168],[247,168]],"region":{"top_left_x":247,"top_left_y":124,"width":1474,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d2378d31c75403fa90f4d571b584b31","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4ee5f8a545b45f7a4748df749544d66","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,249],[245,249]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"917ef1c5e9cc4743b04f5568a2ab5d0d","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[739,243],[1278,243],[1278,303],[739,303]],"region":{"top_left_x":739,"top_left_y":242,"width":540,"height":61},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd7043ede1404a9a9e55ca582d0eb8f0","type":"section_header","conversion_output":false,"children_ids":["f6ed91b578b04873bfb18501d56695b7"],"text":"","text_display":""},{"cnt":[[743,249],[1274,249],[1274,294],[743,294]],"region":{"top_left_x":743,"top_left_y":249,"width":532,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6ed91b578b04873bfb18501d56695b7","type":"text","conversion_output":true,"parent_id":"bd7043ede1404a9a9e55ca582d0eb8f0","text":"STATISTICAL ANALYSIS PLAN","text_display":"\n\n\\section*{STATISTICAL ANALYSIS PLAN}","confidence":1,"confidence_rate":1},{"cnt":[[241,372],[462,372],[462,419],[241,419]],"region":{"top_left_x":240,"top_left_y":371,"width":222,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e4cccc971ea4150bcbd61399f4c9196","type":"section_header","conversion_output":false,"children_ids":["d5e0223245094cd7abe4463481bb8589"],"text":"","text_display":""},{"cnt":[[245,374],[458,374],[458,415],[245,415]],"region":{"top_left_x":244,"top_left_y":373,"width":214,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5e0223245094cd7abe4463481bb8589","type":"text","conversion_output":true,"parent_id":"1e4cccc971ea4150bcbd61399f4c9196","text":"Introduction","text_display":"\n\n\\section*{Introduction}","confidence":1,"confidence_rate":1},{"cnt":[[245,438],[1815,438],[1815,483],[245,483]],"region":{"top_left_x":244,"top_left_y":438,"width":1572,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c49a97c8ebef432f9935e6f5f900f571","type":"text","conversion_output":true,"text":"This Statistical Analysis Plan describes the analysis of the prospective randomized controlled trial that","text_display":"\n\nThis Statistical Analysis Plan describes the analysis of the prospective randomized controlled trial that","confidence":1,"confidence_rate":1},{"cnt":[[245,483],[1841,483],[1841,529],[245,529]],"region":{"top_left_x":244,"top_left_y":483,"width":1598,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"add507484c084aa19cf1eb298889d8ae","type":"text","conversion_output":true,"text":"has been reviewed and approved by the Committee on Clinical Investigations at Beth Israel Deaconess","text_display":" has been reviewed and approved by the Committee on Clinical Investigations at Beth Israel Deaconess","confidence":1,"confidence_rate":1},{"cnt":[[245,529],[1848,529],[1848,576],[245,576]],"region":{"top_left_x":244,"top_left_y":528,"width":1604,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33196223b12a491ab5450320dbb4a5a8","type":"text","conversion_output":true,"text":"Medical Center (2014P000413) and will be conducted in accordance with all applicable human subjects'","text_display":" Medical Center (2014P000413) and will be conducted in accordance with all applicable human subjects'","confidence":1,"confidence_rate":1},{"cnt":[[245,576],[1139,576],[1139,621],[245,621]],"region":{"top_left_x":244,"top_left_y":575,"width":895,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf484fd0e195484797c28c2743f39863","type":"text","conversion_output":true,"text":"research requirements and applicable federal regulations.","text_display":" research requirements and applicable federal regulations.","confidence":1,"confidence_rate":1},{"cnt":[[241,653],[449,653],[449,707],[241,707]],"region":{"top_left_x":240,"top_left_y":653,"width":210,"height":54},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"106ca8e23f884f609e799e00cbce2103","type":"section_header","conversion_output":false,"children_ids":["0e4126badf464375a32b64f323c2cc69"],"text":"","text_display":""},{"cnt":[[245,657],[445,657],[445,703],[245,703]],"region":{"top_left_x":244,"top_left_y":657,"width":201,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e4126badf464375a32b64f323c2cc69","type":"text","conversion_output":true,"parent_id":"106ca8e23f884f609e799e00cbce2103","text":"Study Aims","text_display":"\n\n\\section*{Study Aims}","confidence":1,"confidence_rate":1},{"cnt":[[245,705],[1880,705],[1880,750],[245,750]],"region":{"top_left_x":244,"top_left_y":704,"width":1636,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa25e0d0143b44bda08acb524cf65a6c","type":"text","conversion_output":true,"text":"Briefly, this randomized, factorial clinical trial evaluates the effect of intravenous acetaminophen versus","text_display":"\n\nBriefly, this randomized, factorial clinical trial evaluates the effect of intravenous acetaminophen versus","confidence":1,"confidence_rate":1},{"cnt":[[245,748],[1880,748],[1880,793],[245,793]],"region":{"top_left_x":244,"top_left_y":747,"width":1636,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3af814a05eca47e9b2d8fe07f218d5c9","type":"text","conversion_output":true,"text":"placebo, combined with intravenous propofol versus dexmedetomidine, for postoperative sedation and","text_display":" placebo, combined with intravenous propofol versus dexmedetomidine, for postoperative sedation and","confidence":1,"confidence_rate":1},{"cnt":[[245,795],[1880,795],[1880,840],[245,840]],"region":{"top_left_x":244,"top_left_y":794,"width":1636,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5103f47f4944045adb17ea4116a597b","type":"text","conversion_output":true,"text":"analgesia respectively, in adult patients 60 years or older undergoing coronary artery bypass grafting","text_display":" analgesia respectively, in adult patients 60 years or older undergoing coronary artery bypass grafting","confidence":1,"confidence_rate":1},{"cnt":[[245,842],[1880,842],[1880,887],[245,887]],"region":{"top_left_x":244,"top_left_y":842,"width":1636,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b9238ba3c5d495898b5281075368cc0","type":"text","conversion_output":true,"text":"(CABG) or combined CABG/valve surgeries to assess the incidence and duration of postoperative delirium.","text_display":" (CABG) or combined CABG/valve surgeries to assess the incidence and duration of postoperative delirium.","confidence":0.99658203125,"confidence_rate":0.9999682984344538},{"cnt":[[241,915],[479,915],[479,969],[241,969]],"region":{"top_left_x":240,"top_left_y":915,"width":240,"height":54},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a36b8dce6b5d462d9fec27ae22a7a481","type":"section_header","conversion_output":false,"children_ids":["e50832ede36e42a281a68854c99f7262"],"text":"","text_display":""},{"cnt":[[245,922],[475,922],[475,965],[245,965]],"region":{"top_left_x":244,"top_left_y":921,"width":231,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e50832ede36e42a281a68854c99f7262","type":"text","conversion_output":true,"parent_id":"a36b8dce6b5d462d9fec27ae22a7a481","text":"Study Design","text_display":"\n\n\\section*{Study Design}","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1828,967],[1828,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":966,"width":1585,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87ac92459da44babb3d2cab56dab56eb","type":"text","conversion_output":true,"text":"This is a single-center randomized controlled factorial trial of two sedative and two analgesic regimens.","text_display":"\n\nThis is a single-center randomized controlled factorial trial of two sedative and two analgesic regimens.","confidence":1,"confidence_rate":1},{"cnt":[[241,1044],[707,1044],[707,1098],[241,1098]],"region":{"top_left_x":240,"top_left_y":1044,"width":467,"height":54},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd3cbb35b4204ef28aefe25d8cf35b14","type":"section_header","conversion_output":false,"children_ids":["785223b09988497b9b3d158a157d2e72"],"text":"","text_display":""},{"cnt":[[245,1048],[703,1048],[703,1094],[245,1094]],"region":{"top_left_x":244,"top_left_y":1048,"width":459,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"785223b09988497b9b3d158a157d2e72","type":"text","conversion_output":true,"parent_id":"fd3cbb35b4204ef28aefe25d8cf35b14","text":"Study Population and Sites","text_display":"\n\n\\section*{Study Population and Sites}","confidence":1,"confidence_rate":1},{"cnt":[[245,1094],[1880,1092],[1880,1139],[245,1141]],"region":{"top_left_x":244,"top_left_y":1092,"width":1636,"height":49},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed8822a1d70d4fef8678b539b079f336","type":"text","conversion_output":true,"text":"The study will prospectively enroll patients undergoing cardiac surgery at Beth Israel Deaconess Medical","text_display":"\n\nThe study will prospectively enroll patients undergoing cardiac surgery at Beth Israel Deaconess Medical","confidence":1,"confidence_rate":1},{"cnt":[[245,1139],[1876,1139],[1876,1184],[245,1184]],"region":{"top_left_x":244,"top_left_y":1138,"width":1632,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b6fcd596d5a4e03828c291517514b1b","type":"text","conversion_output":true,"text":"Center in Boston, Massachusetts. This includes patients enrolled between September 2015 and April 2018.","text_display":" Center in Boston, Massachusetts. This includes patients enrolled between September 2015 and April 2018.","confidence":1,"confidence_rate":1},{"cnt":[[241,1216],[507,1216],[507,1265],[241,1265]],"region":{"top_left_x":240,"top_left_y":1216,"width":268,"height":50},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b513ab76b10488f8fb8e5054e6c5617","type":"section_header","conversion_output":false,"children_ids":["00b998b10f2d4b1eb3b677d495d61ad8"],"text":"","text_display":""},{"cnt":[[245,1220],[501,1220],[501,1261],[245,1261]],"region":{"top_left_x":244,"top_left_y":1220,"width":257,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00b998b10f2d4b1eb3b677d495d61ad8","type":"text","conversion_output":true,"parent_id":"6b513ab76b10488f8fb8e5054e6c5617","text":"Randomization","text_display":"\n\n\\section*{Randomization}","confidence":1,"confidence_rate":1},{"cnt":[[245,1265],[1880,1265],[1880,1313],[245,1313]],"region":{"top_left_x":244,"top_left_y":1265,"width":1636,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd23387615654dff8dc58307dd1d4899","type":"text","conversion_output":true,"text":"Randomization will be by pre-prepared using a computer generated block randomization in SAS 9.3. Details","text_display":"\n\nRandomization will be by pre-prepared using a computer generated block randomization in SAS 9.3. Details","confidence":0.9980478286743164,"confidence_rate":0.999982072827706},{"cnt":[[245,1311],[1878,1311],[1878,1360],[245,1360]],"region":{"top_left_x":244,"top_left_y":1310,"width":1634,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a48392620dc24f45bab920b9c7906870","type":"text","conversion_output":true,"text":"of the block size are kept confidential until the completion of study enrollment. This schema will be created","text_display":" of the block size are kept confidential until the completion of study enrollment. This schema will be created","confidence":1,"confidence_rate":1},{"cnt":[[245,1358],[1880,1358],[1880,1405],[245,1405]],"region":{"top_left_x":244,"top_left_y":1357,"width":1636,"height":49},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e1b94c396054c4c8943ca03c5bc3431","type":"text","conversion_output":true,"text":"by the unblinded statistician (Ariel Mueller, MA) and sent to the research pharmacy. Members of the","text_display":" by the unblinded statistician (Ariel Mueller, MA) and sent to the research pharmacy. Members of the","confidence":1,"confidence_rate":1},{"cnt":[[245,1405],[1880,1405],[1880,1450],[245,1450]],"region":{"top_left_x":244,"top_left_y":1405,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9f756d8835043ad8438de86e1ce59a3","type":"text","conversion_output":true,"text":"research pharmacy will be responsible for preparing and dispensing the study medications following an","text_display":" research pharmacy will be responsible for preparing and dispensing the study medications following an","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[1878,1448],[1878,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1448,"width":1634,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a9a833ed308426cbdd600c66519d09c","type":"text","conversion_output":true,"text":"active order for study medications. Specifically this includes preparation and blinding of the placebo in","text_display":" active order for study medications. Specifically this includes preparation and blinding of the placebo in","confidence":1,"confidence_rate":1},{"cnt":[[245,1495],[1023,1495],[1023,1540],[245,1540]],"region":{"top_left_x":244,"top_left_y":1495,"width":779,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15f5d6323205437cbc91aad45114535f","type":"text","conversion_output":true,"text":"accordance with the study randomization schema.","text_display":" accordance with the study randomization schema.","confidence":1,"confidence_rate":1},{"cnt":[[245,1577],[1540,1577],[1540,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1576,"width":1297,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5125b0c15a4d4a25934fe9ffafbab0ec","type":"text","conversion_output":true,"text":"Patients will be randomized to one of four groups in a \\(1: 1: 1: 1\\) fashion. This includes:","text_display":"\n\nPatients will be randomized to one of four groups in a \\(1: 1: 1: 1\\) fashion. This includes:","confidence":0.9409465789794922,"confidence_rate":0.9993526679982592},{"cnt":[[305,1620],[978,1620],[978,1665],[305,1665]],"region":{"top_left_x":305,"top_left_y":1619,"width":673,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28b524fa140142fcb9924fb1cc22e0c0","type":"text","conversion_output":true,"text":"- Acetaminophen and Dexmedetomidine","text_display":"\n- Acetaminophen and Dexmedetomidine","confidence":1,"confidence_rate":1},{"cnt":[[305,1663],[827,1663],[827,1708],[305,1708]],"region":{"top_left_x":305,"top_left_y":1662,"width":523,"height":47},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce959808ded6448a992b59c6b69acee5","type":"text","conversion_output":true,"text":"- Acetaminophen and Propofol","text_display":"\n- Acetaminophen and Propofol","confidence":1,"confidence_rate":1},{"cnt":[[305,1706],[862,1706],[862,1747],[305,1747]],"region":{"top_left_x":305,"top_left_y":1705,"width":557,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c5482e15c354febb3d6afe473ce65d4","type":"text","conversion_output":true,"text":"- Placebo and Dexmedetomidine","text_display":"\n- Placebo and Dexmedetomidine","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[711,1745],[711,1790],[305,1790]],"region":{"top_left_x":305,"top_left_y":1744,"width":407,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8ae2e2a9c9e43ae8cea9f65f80e296f","type":"text","conversion_output":true,"text":"- Placebo and Propofol","text_display":"\n- Placebo and Propofol","confidence":1,"confidence_rate":1},{"cnt":[[241,1822],[565,1822],[565,1876],[241,1876]],"region":{"top_left_x":240,"top_left_y":1821,"width":326,"height":55},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fabad903553436c8e327db3d136fbbc","type":"section_header","conversion_output":false,"children_ids":["4d1cff9625ef479c963472bdf3401d66"],"text":"","text_display":""},{"cnt":[[245,1826],[561,1826],[561,1871],[245,1871]],"region":{"top_left_x":244,"top_left_y":1826,"width":317,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d1cff9625ef479c963472bdf3401d66","type":"text","conversion_output":true,"parent_id":"5fabad903553436c8e327db3d136fbbc","text":"Primary Endpoints","text_display":"\n\n\\section*{Primary Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[245,1873],[1880,1873],[1880,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1873,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50aaefea70264468bce9c36b7fbcfd6d","type":"text","conversion_output":true,"text":"The primary endpoint will be the incidence of in-hospital delirium. This is assessed via the Confusion","text_display":"\n\nThe primary endpoint will be the incidence of in-hospital delirium. This is assessed via the Confusion","confidence":1,"confidence_rate":1},{"cnt":[[245,1919],[1880,1919],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1918,"width":1636,"height":48},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"015a016f3b604cd5b3a54c48f18a26b2","type":"text","conversion_output":true,"text":"Assessment Method (or CAM-ICU for intubated patients) daily postoperatively, as specified in the study","text_display":" Assessment Method (or CAM-ICU for intubated patients) daily postoperatively, as specified in the study","confidence":0.9917030334472656,"confidence_rate":0.9999221378168458},{"cnt":[[245,1964],[1880,1964],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":1636,"height":51},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcbe7ac5479e46daa8fc0e22bcf1b94f","type":"text","conversion_output":true,"text":"protocol. If a patient is noted to be positive for delirium on any postoperative day, they will have been","text_display":" protocol. If a patient is noted to be positive for delirium on any postoperative day, they will have been","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1076,2011],[1076,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2010,"width":833,"height":47},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc6e5f224dee4726a3f595e1eed93413","type":"text","conversion_output":true,"text":"documented as achieving the primary study endpoint.","text_display":" documented as achieving the primary study endpoint.","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1880,2093],[1880,2138],[245,2138]],"region":{"top_left_x":244,"top_left_y":2092,"width":1636,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88cce5d1790c42af8fd4a20ccaa561dd","type":"text","conversion_output":true,"text":"Our pre-specified primary analysis will assess the incidence of delirium between patients receiving IV","text_display":"\n\nOur pre-specified primary analysis will assess the incidence of delirium between patients receiving IV","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[743,2136],[743,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":500,"height":50},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27c41c1fc92a4798ad108f3aecff5f70","type":"text","conversion_output":true,"text":"acetaminophen versus placebo.","text_display":" acetaminophen versus placebo.","confidence":1,"confidence_rate":1},{"cnt":[[241,2213],[617,2213],[617,2267],[241,2267]],"region":{"top_left_x":240,"top_left_y":2212,"width":377,"height":55},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a17e866c291745a2ba5f1342159a07bb","type":"section_header","conversion_output":false,"children_ids":["5948933de191461a8581b752e63d71de"],"text":"","text_display":""},{"cnt":[[245,2217],[610,2217],[610,2262],[245,2262]],"region":{"top_left_x":244,"top_left_y":2217,"width":367,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5948933de191461a8581b752e63d71de","type":"text","conversion_output":true,"parent_id":"a17e866c291745a2ba5f1342159a07bb","text":"Secondary Endpoints","text_display":"\n\n\\section*{Secondary Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[913,2264],[913,2310],[245,2310]],"region":{"top_left_x":244,"top_left_y":2264,"width":670,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56758c29b7304bb490593e64996415e3","type":"text","conversion_output":true,"text":"Secondary outcomes for this study include:","text_display":"\n\nSecondary outcomes for this study include:","confidence":1,"confidence_rate":1},{"cnt":[[305,2312],[681,2312],[681,2353],[305,2353]],"region":{"top_left_x":305,"top_left_y":2311,"width":377,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fdde286bd1042879c4d2ad56ae010ea","type":"text","conversion_output":true,"text":"- Duration of delirium","text_display":"\n- Duration of delirium","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23605dc21ced4db1b1013229be15278b","type":"page_info","conversion_output":false,"text":"12","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-13","page":13,"lines":[{"cnt":[[245,125],[1721,125],[1721,170],[245,170]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce7cf44fd4f144e09108346f4eee7cd6","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4186d13067d40daa515f8f48710e175","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"660502ba0dc2412cb606a07a7ded8017","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[432,249],[1884,249],[1884,294],[432,294]],"region":{"top_left_x":431,"top_left_y":249,"width":1454,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db7339d63a4a445ca56ac97ddb65b046","type":"text","conversion_output":true,"text":"- Definition: The number of days of being positive for delirium on the CAM or CAM-ICU","text_display":"\n- Definition: The number of days of being positive for delirium on the CAM or CAM-ICU","confidence":1,"confidence_rate":1},{"cnt":[[492,292],[1880,292],[1880,333],[492,333]],"region":{"top_left_x":491,"top_left_y":292,"width":1389,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18376f8451254c9da488776cd0827cd4","type":"text","conversion_output":true,"text":"instruments will be recorded and assessed. This will be assessed as a continuous variable.","text_display":" instruments will be recorded and assessed. This will be assessed as a continuous variable.","confidence":0.9951171875,"confidence_rate":0.9999484774075793},{"cnt":[[305,333],[1697,333],[1697,376],[305,376]],"region":{"top_left_x":305,"top_left_y":333,"width":1393,"height":43},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7459715264749a88011440dc13a6a77","type":"text","conversion_output":true,"text":"- Postoperative cognitive decline at discharge, one month and one year postoperatively","text_display":"\n- Postoperative cognitive decline at discharge, one month and one year postoperatively","confidence":1,"confidence_rate":1},{"cnt":[[430,374],[1884,374],[1884,415],[430,415]],"region":{"top_left_x":429,"top_left_y":373,"width":1456,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1476c031f6bb4eb597e5baf82fd5143e","type":"text","conversion_output":true,"text":"- Definition: This will be assessed by using the change in Montreal Cognitive Assessment","text_display":"\n- Definition: This will be assessed by using the change in Montreal Cognitive Assessment","confidence":1,"confidence_rate":1},{"cnt":[[494,412],[1833,412],[1833,458],[494,458]],"region":{"top_left_x":494,"top_left_y":412,"width":1339,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e7cce476dde4bdcbf36350dbafe8b5a","type":"text","conversion_output":true,"text":"score at this time point since baseline. This will be assessed as a continuous variable.","text_display":" score at this time point since baseline. This will be assessed as a continuous variable.","confidence":0.9936552047729492,"confidence_rate":0.9999315613851784},{"cnt":[[305,455],[1566,455],[1566,501],[305,501]],"region":{"top_left_x":305,"top_left_y":455,"width":1262,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10b7e2efef2b4d63bb57bbb9cb961ab6","type":"text","conversion_output":true,"text":"- Breakthrough analgesic requirements within the first 48 hours postoperatively","text_display":"\n- Breakthrough analgesic requirements within the first 48 hours postoperatively","confidence":1,"confidence_rate":1},{"cnt":[[432,494],[1884,494],[1884,539],[432,539]],"region":{"top_left_x":431,"top_left_y":494,"width":1454,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b653fc2dc8e24b36b76b5d14e9dcc0f6","type":"text","conversion_output":true,"text":"- Definition: This will be assessed by calculating the total morphine equivalent administered","text_display":"\n- Definition: This will be assessed by calculating the total morphine equivalent administered","confidence":1,"confidence_rate":1},{"cnt":[[494,535],[1880,535],[1880,578],[494,578]],"region":{"top_left_x":494,"top_left_y":534,"width":1386,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"708c069af7cc466caeb7b2686976c18b","type":"text","conversion_output":true,"text":"in the first 48 hours postoperatively, with time zero starting at ICU admission. This will be","text_display":" in the first 48 hours postoperatively, with time zero starting at ICU admission. This will be","confidence":1,"confidence_rate":1},{"cnt":[[494,576],[1042,576],[1042,614],[494,614]],"region":{"top_left_x":494,"top_left_y":575,"width":548,"height":40},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1cc7ad182bd4e2f9557bcdd9a2dab99","type":"text","conversion_output":true,"text":"assessed as a continuous variable.","text_display":" assessed as a continuous variable.","confidence":1,"confidence_rate":1},{"cnt":[[305,614],[973,614],[973,660],[305,660]],"region":{"top_left_x":305,"top_left_y":614,"width":669,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b29786db5c6341d58e999fb85704faec","type":"text","conversion_output":true,"text":"- Intensive care unit (ICU) length of stay","text_display":"\n- Intensive care unit (ICU) length of stay","confidence":1,"confidence_rate":1},{"cnt":[[432,657],[1766,657],[1766,700],[432,700]],"region":{"top_left_x":431,"top_left_y":657,"width":1336,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b569fa9d3b8a4cbc8311bfd6c18e2ef9","type":"text","conversion_output":true,"text":"- Definition: This will be defined as the number of hours admitted in the ICU prior to","text_display":"\n- Definition: This will be defined as the number of hours admitted in the ICU prior to","confidence":1,"confidence_rate":1},{"cnt":[[494,696],[1876,696],[1876,741],[494,741]],"region":{"top_left_x":494,"top_left_y":696,"width":1382,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69435c88ef3a4476b61066416d2c7a5a","type":"text","conversion_output":true,"text":"transfer to the general floor. This will be assessed as a continuous variable and reported","text_display":" transfer to the general floor. This will be assessed as a continuous variable and reported","confidence":0.982421875,"confidence_rate":0.9998133389502918},{"cnt":[[494,735],[638,735],[638,776],[494,776]],"region":{"top_left_x":494,"top_left_y":734,"width":145,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12c445a425e14f66a352e8cf27fa4a73","type":"text","conversion_output":true,"text":"in hours.","text_display":" in hours.","confidence":1,"confidence_rate":1},{"cnt":[[305,778],[724,778],[724,823],[305,823]],"region":{"top_left_x":305,"top_left_y":777,"width":420,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f7a477cfec54a3594fc8d49dde9b5e2","type":"text","conversion_output":true,"text":"- Hospital length of stay","text_display":"\n- Hospital length of stay","confidence":1,"confidence_rate":1},{"cnt":[[432,821],[1777,821],[1777,862],[432,862]],"region":{"top_left_x":431,"top_left_y":820,"width":1346,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"479fb313f4284b4085f9bc731ba714a8","type":"text","conversion_output":true,"text":"- Definition: This will be calculated as the day of hospital discharge minus the day of","text_display":"\n- Definition: This will be calculated as the day of hospital discharge minus the day of","confidence":1,"confidence_rate":1},{"cnt":[[494,859],[1837,859],[1837,904],[494,904]],"region":{"top_left_x":494,"top_left_y":859,"width":1343,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13aa0681fada45469082e217ba61156f","type":"text","conversion_output":true,"text":"surgery plus one. This will be assessed as a continuous variable and reported in days.","text_display":" surgery plus one. This will be assessed as a continuous variable and reported in days.","confidence":1,"confidence_rate":1},{"cnt":[[305,902],[1377,902],[1377,947],[305,947]],"region":{"top_left_x":305,"top_left_y":902,"width":1073,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f8d28e3bb39456b8dd58df41febfda9","type":"text","conversion_output":true,"text":"- Predefined potential adverse effects of the study drugs including:","text_display":"\n- Predefined potential adverse effects of the study drugs including:","confidence":1,"confidence_rate":1},{"cnt":[[432,941],[1257,941],[1257,986],[432,986]],"region":{"top_left_x":431,"top_left_y":941,"width":826,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f27a6c7cd02449299d9b91f3212859bc","type":"text","conversion_output":true,"text":"- Number and duration of episodes of hypotension","text_display":"\n- Number and duration of episodes of hypotension","confidence":1,"confidence_rate":1},{"cnt":[[556,982],[1850,982],[1850,1025],[556,1025]],"region":{"top_left_x":556,"top_left_y":981,"width":1294,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26a0c41d2a1549c78e48e7bc145f932b","type":"text","conversion_output":true,"text":"- Definition: This is predefined as less than 90 mm Hg systolic blood pressure for","text_display":"\n- Definition: This is predefined as less than 90 mm Hg systolic blood pressure for","confidence":0.49975156993605196,"confidence_rate":0.9924887410850564},{"cnt":[[614,1023],[947,1023],[947,1059],[614,1059]],"region":{"top_left_x":614,"top_left_y":1022,"width":334,"height":38},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00efb87a100e4564aaab334b3ce4dcc8","type":"text","conversion_output":true,"text":"five minutes or more","text_display":" five minutes or more","confidence":1,"confidence_rate":1},{"cnt":[[434,1061],[1248,1061],[1248,1104],[434,1104]],"region":{"top_left_x":433,"top_left_y":1061,"width":816,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c8c353d7f23430d80c66ba5fdf29aa3","type":"text","conversion_output":true,"text":"- Number and duration of episodes of bradycardia","text_display":"\n- Number and duration of episodes of bradycardia","confidence":1,"confidence_rate":1},{"cnt":[[556,1100],[1588,1100],[1588,1145],[556,1145]],"region":{"top_left_x":556,"top_left_y":1100,"width":1032,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9dc3af07f5f146bda0dc864193a64472","type":"text","conversion_output":true,"text":"- Definition: This is predefined as less than 40 beats per minute.","text_display":"\n- Definition: This is predefined as less than 40 beats per minute.","confidence":1,"confidence_rate":1},{"cnt":[[305,1143],[1665,1143],[1665,1188],[305,1188]],"region":{"top_left_x":305,"top_left_y":1142,"width":1361,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ed382f5cd364261b06a787f0ea4c3f9","type":"text","conversion_output":true,"text":"- The proportion of patients who complete the protocol successfully will be measured.","text_display":"\n- The proportion of patients who complete the protocol successfully will be measured.","confidence":1,"confidence_rate":1},{"cnt":[[305,1186],[1727,1186],[1727,1229],[305,1229]],"region":{"top_left_x":305,"top_left_y":1185,"width":1423,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f247cd5272d49dcbbe2899101469704","type":"text","conversion_output":true,"text":"- If this sedation and analgesic regimen is abandoned by the clinicians, the reason will be","text_display":"\n- If this sedation and analgesic regimen is abandoned by the clinicians, the reason will be","confidence":1,"confidence_rate":1},{"cnt":[[370,1225],[1085,1225],[1085,1270],[370,1270]],"region":{"top_left_x":369,"top_left_y":1224,"width":716,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e246300fa1c74118b101790fcc8f89c8","type":"text","conversion_output":true,"text":"qualitatively described at the end of the study.","text_display":" qualitatively described at the end of the study.","confidence":1,"confidence_rate":1},{"cnt":[[305,1268],[909,1268],[909,1313],[305,1313]],"region":{"top_left_x":305,"top_left_y":1267,"width":604,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0dc8aaef9214ab09477616fbc3cd984","type":"text","conversion_output":true,"text":"- Levels of inflammatory biomarkers","text_display":"\n- Levels of inflammatory biomarkers","confidence":1,"confidence_rate":1},{"cnt":[[241,1345],[436,1345],[436,1394],[241,1394]],"region":{"top_left_x":240,"top_left_y":1344,"width":197,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8571e6c01a34e3ba6fdf3b700e6edd7","type":"section_header","conversion_output":false,"children_ids":["d79d42c7ffbf45a79d1abb2c8c95c121"],"text":"","text_display":""},{"cnt":[[245,1349],[432,1349],[432,1388],[245,1388]],"region":{"top_left_x":244,"top_left_y":1349,"width":188,"height":39},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d79d42c7ffbf45a79d1abb2c8c95c121","type":"text","conversion_output":true,"parent_id":"c8571e6c01a34e3ba6fdf3b700e6edd7","text":"Covariates","text_display":"\n\n\\section*{Covariates}","confidence":1,"confidence_rate":1},{"cnt":[[245,1394],[1880,1394],[1880,1439],[245,1439]],"region":{"top_left_x":244,"top_left_y":1394,"width":1636,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b3054edf1654271890522473d9098c4","type":"text","conversion_output":true,"text":"Trial data will be collected managed using REDCap electronic data capture tools hosted at Beth Israel","text_display":"\n\nTrial data will be collected managed using REDCap electronic data capture tools hosted at Beth Israel","confidence":1,"confidence_rate":1},{"cnt":[[245,1439],[1880,1439],[1880,1485],[245,1485]],"region":{"top_left_x":244,"top_left_y":1439,"width":1636,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a94d86b80a454e3db01ff59531dfcdf1","type":"text","conversion_output":true,"text":"Deaconess Medical Center. REDCap (Research Electronic Data Capture) is a secure, web-based","text_display":" Deaconess Medical Center. REDCap (Research Electronic Data Capture) is a secure, web-based","confidence":1,"confidence_rate":1},{"cnt":[[245,1487],[1880,1487],[1880,1532],[245,1532]],"region":{"top_left_x":244,"top_left_y":1486,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39400fc5ac1340bbbb2a4219b33945b4","type":"text","conversion_output":true,"text":"application designed to support data capture for research studies, providing 1) an intuitive interface for","text_display":" application designed to support data capture for research studies, providing 1) an intuitive interface for","confidence":0.9931640625,"confidence_rate":0.9999382054269228},{"cnt":[[245,1532],[1880,1532],[1880,1577],[245,1577]],"region":{"top_left_x":244,"top_left_y":1531,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f3142dfb29246478237bfdfc9dcec90","type":"text","conversion_output":true,"text":"validated data entry; 2) audit trails for tracking data manipulation and export procedures; 3) automated","text_display":" validated data entry; 2) audit trails for tracking data manipulation and export procedures; 3) automated","confidence":0.51171875,"confidence_rate":0.993872245124697},{"cnt":[[245,1577],[1880,1577],[1880,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1576,"width":1636,"height":47},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f4ddf04068d4044869a7ca04eb1eb40","type":"text","conversion_output":true,"text":"export procedures for seamless data downloads to common statistical packages; and 4) procedures for","text_display":" export procedures for seamless data downloads to common statistical packages; and 4) procedures for","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1880,1624],[1880,1669],[245,1669]],"region":{"top_left_x":244,"top_left_y":1624,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24677cb6d2a4472f9565317a6b44147f","type":"text","conversion_output":true,"text":"importing data from external sources. The REDCap system includes validation rules for data entry to help","text_display":" importing data from external sources. The REDCap system includes validation rules for data entry to help","confidence":1,"confidence_rate":1},{"cnt":[[245,1671],[1384,1671],[1384,1714],[245,1714]],"region":{"top_left_x":244,"top_left_y":1671,"width":1140,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3feb21ac09504a9f9b1030edbe100626","type":"text","conversion_output":true,"text":"ensure data accuracy, and has a full audit trail of data entry and changes.","text_display":" ensure data accuracy, and has a full audit trail of data entry and changes.","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1796],[245,1796]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ce1207bfd3c4fc9941fb8677bb9ab63","type":"text","conversion_output":true,"text":"Data collection includes the participant's demographic data such as age, sex, ethnicity, race and body mass","text_display":"\n\nData collection includes the participant's demographic data such as age, sex, ethnicity, race and body mass","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1880,1796],[1880,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c34c2d8c5ded40ba9a63dc434dadadf9","type":"text","conversion_output":true,"text":"index will be recorded. Patient comorbid conditions, surgery and anesthetic drugs used will be obtained","text_display":" index will be recorded. Patient comorbid conditions, surgery and anesthetic drugs used will be obtained","confidence":1,"confidence_rate":1},{"cnt":[[245,1843],[1880,1843],[1880,1888],[245,1888]],"region":{"top_left_x":244,"top_left_y":1843,"width":1636,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffd01e9d92c54f94961fae19336d6e07","type":"text","conversion_output":true,"text":"from Society of Thoracic Surgery database and Anesthesia Information Management System, which is a","text_display":" from Society of Thoracic Surgery database and Anesthesia Information Management System, which is a","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1880,1886],[1880,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1886,"width":1636,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3871a37b84a24d019d5ed8cc8ffcc18e","type":"text","conversion_output":true,"text":"clinical outcomes registry that records and assesses the care of adult patients undergoing cardiac","text_display":" clinical outcomes registry that records and assesses the care of adult patients undergoing cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,1934],[1880,1934],[1880,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1933,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81e8b17c58a941efbc29049f00343ae9","type":"text","conversion_output":true,"text":"procedures at participating hospitals. Pertinent characteristics include preoperative medications,","text_display":" procedures at participating hospitals. Pertinent characteristics include preoperative medications,","confidence":1,"confidence_rate":1},{"cnt":[[245,1979],[1880,1979],[1880,2026],[245,2026]],"region":{"top_left_x":244,"top_left_y":1978,"width":1636,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0951d867f59644d28ae8df2c94e3be78","type":"text","conversion_output":true,"text":"comorbidities, surgical characteristics, and postoperative outcomes, including 30 day mortality and major","text_display":" comorbidities, surgical characteristics, and postoperative outcomes, including 30 day mortality and major","confidence":1,"confidence_rate":1},{"cnt":[[245,2024],[1880,2024],[1880,2071],[245,2071]],"region":{"top_left_x":244,"top_left_y":2023,"width":1636,"height":49},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80914e527a294cb9987b24858f2c9717","type":"text","conversion_output":true,"text":"adverse events like renal failure during hospital admission. Information on the sedatives and analgesics","text_display":" adverse events like renal failure during hospital admission. Information on the sedatives and analgesics","confidence":1,"confidence_rate":1},{"cnt":[[245,2071],[1880,2071],[1880,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ee5ede849aa45e7b9d577078b02c70b","type":"text","conversion_output":true,"text":"given within six hours prior to initiation of the cognitive assessment will be recorded, as to determine","text_display":" given within six hours prior to initiation of the cognitive assessment will be recorded, as to determine","confidence":1,"confidence_rate":1},{"cnt":[[245,2118],[1880,2118],[1880,2163],[245,2163]],"region":{"top_left_x":244,"top_left_y":2118,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4db413c0737b4a4fae8dbf7042a7becc","type":"text","conversion_output":true,"text":"whether there is an effect on performance. The total opioid dosage administered during the first 48 hours","text_display":" whether there is an effect on performance. The total opioid dosage administered during the first 48 hours","confidence":1,"confidence_rate":1},{"cnt":[[245,2161],[1781,2161],[1781,2211],[245,2211]],"region":{"top_left_x":244,"top_left_y":2161,"width":1538,"height":50},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e59c89cb50fc4a5084cf77dc2fe88f44","type":"text","conversion_output":true,"text":"post operatively, pain scores and patient delirium assessment data will be collected using REDCap.","text_display":" post operatively, pain scores and patient delirium assessment data will be collected using REDCap.","confidence":1,"confidence_rate":1},{"cnt":[[245,2243],[1880,2243],[1880,2290],[245,2290]],"region":{"top_left_x":244,"top_left_y":2242,"width":1636,"height":49},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"109728beef744728ab9be2c66bc537b4","type":"text","conversion_output":true,"text":"The overall flow and reporting of study recruitment, enrollment and follow up will follow the CONSORT","text_display":"\n\nThe overall flow and reporting of study recruitment, enrollment and follow up will follow the CONSORT","confidence":1,"confidence_rate":1},{"cnt":[[245,2290],[1265,2290],[1265,2335],[245,2335]],"region":{"top_left_x":244,"top_left_y":2290,"width":1022,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28cc14c53c3f4bcca86bc34c1e616daa","type":"text","conversion_output":true,"text":"recommendations for the reporting of randomized controlled trials.","text_display":" recommendations for the reporting of randomized controlled trials.","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d535e0e7418b45debdc2355bcb75b68b","type":"page_info","conversion_output":false,"text":"13","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-14","page":14,"lines":[{"cnt":[[245,125],[1721,125],[1721,170],[245,170]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b20fe48622740d7a9db5e0ac8fcf949","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86a8dac926594d9b80df1e539d6c8b94","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,249],[245,249]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b893e633d30749848b2b3f0843869fd9","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,245],[649,245],[649,299],[241,299]],"region":{"top_left_x":240,"top_left_y":244,"width":409,"height":55},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1c1290f22fe4b2cbecedbc5b5be2270","type":"section_header","conversion_output":false,"children_ids":["5e8ee73d78934d438f2d7550c3995d2e"],"text":"","text_display":""},{"cnt":[[245,249],[642,249],[642,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":399,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e8ee73d78934d438f2d7550c3995d2e","type":"text","conversion_output":true,"parent_id":"d1c1290f22fe4b2cbecedbc5b5be2270","text":"Sample Size Estimation","text_display":"\n\n\\section*{Sample Size Estimation}","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efac013e763547368bc2bc2074ee81f2","type":"text","conversion_output":true,"text":"This is a prospective, randomized, placebo controlled, double-blinded, factorial design study consisting of 120","text_display":"\n\nThis is a prospective, randomized, placebo controlled, double-blinded, factorial design study consisting of 120","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02f1bdbf8de440d795083c3b45515d3b","type":"text","conversion_output":true,"text":"patients to assess the incidence and duration of postoperative delirium following cardiac surgery. From the","text_display":" patients to assess the incidence and duration of postoperative delirium following cardiac surgery. From the","confidence":1,"confidence_rate":1},{"cnt":[[245,387],[1882,387],[1882,432],[245,432]],"region":{"top_left_x":244,"top_left_y":386,"width":1639,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ed64b68f7df4566a06c4da0d9c83147","type":"text","conversion_output":true,"text":"previous delirium studies conducted at our institution, the baseline delirium incidence was \\(50 \\%\\). The pilot","text_display":" previous delirium studies conducted at our institution, the baseline delirium incidence was \\(50 \\%\\). The pilot","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[245,434],[1880,434],[1880,479],[245,479]],"region":{"top_left_x":244,"top_left_y":433,"width":1636,"height":47},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c762524c44dc479998a6f3f8d2c507cf","type":"text","conversion_output":true,"text":"study showed a 66\\% reduction in the incidence of delirium. For the power calculation, a 50\\% reduction in the","text_display":" study showed a 66\\% reduction in the incidence of delirium. For the power calculation, a 50\\% reduction in the","confidence":0.8794074058532715,"confidence_rate":0.9988634163056295},{"cnt":[[245,477],[1880,477],[1880,526],[245,526]],"region":{"top_left_x":244,"top_left_y":476,"width":1636,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c25a06d102c24b96abf370d32cf2df8f","type":"text","conversion_output":true,"text":"delirium incidence was used. Each group needed 56 patients (alpha \\(=0.05\\) and 1 -Beta \\(=0.80\\) ). This study will","text_display":" delirium incidence was used. Each group needed 56 patients (alpha \\(=0.05\\) and 1 -Beta \\(=0.80\\) ). This study will","confidence":0.8901321143969909,"confidence_rate":0.9990693502503085},{"cnt":[[245,524],[883,524],[883,569],[245,569]],"region":{"top_left_x":244,"top_left_y":524,"width":640,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bd25ff45fd24301b8f0595d4c3fe4f6","type":"text","conversion_output":true,"text":"not be powered for secondary outcomes.","text_display":" not be powered for secondary outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[245,612],[1880,612],[1880,657],[245,657]],"region":{"top_left_x":244,"top_left_y":612,"width":1636,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c89cac188c944dbadfaf9292eaa90a1","type":"text","conversion_output":true,"text":"Because complete data from 112 patients is required in order for analysis, we plan to enroll enough patients","text_display":"\n\nBecause complete data from 112 patients is required in order for analysis, we plan to enroll enough patients","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[245,653],[1880,653],[1880,698],[245,698]],"region":{"top_left_x":244,"top_left_y":653,"width":1636,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e9c4e7e588d4d56b172e14a612d489c","type":"text","conversion_output":true,"text":"to obtain data from 120 patients who received the study intervention ( 60 patients per group - acetaminophen","text_display":" to obtain data from 120 patients who received the study intervention ( 60 patients per group - acetaminophen","confidence":0.9888012175266567,"confidence_rate":0.999905366150653},{"cnt":[[245,694],[1880,694],[1880,737],[245,737]],"region":{"top_left_x":244,"top_left_y":693,"width":1636,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f41bd5a1c3bd4fdbbb9e296c476dc3f4","type":"text","conversion_output":true,"text":"vs. no acetaminophen). We estimate that approximately 150 patients will be enrolled (consented) in order","text_display":" vs. no acetaminophen). We estimate that approximately 150 patients will be enrolled (consented) in order","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1880,735],[1880,776],[245,776]],"region":{"top_left_x":244,"top_left_y":734,"width":1636,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b9022a5a6d24cd2af30e714b0cddaf7","type":"text","conversion_output":true,"text":"to achieve this sample size. This increase is required because it is possible that patients can be withdrawn","text_display":" to achieve this sample size. This increase is required because it is possible that patients can be withdrawn","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[245,773],[1878,773],[1878,816],[245,816]],"region":{"top_left_x":244,"top_left_y":773,"width":1634,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a634572c2d04769a2735de3bc8c4243","type":"text","conversion_output":true,"text":"both before randomization (i.e. cancelled surgery) as well as after randomization but before receiving the","text_display":" both before randomization (i.e. cancelled surgery) as well as after randomization but before receiving the","confidence":1,"confidence_rate":1},{"cnt":[[245,814],[1880,814],[1880,857],[245,857]],"region":{"top_left_x":244,"top_left_y":814,"width":1636,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27eee5fc641d4206959a9f3a3084a3b4","type":"text","conversion_output":true,"text":"study intervention (i.e. change in surgery type intraoperatively). Enrollment will be stopped once a total of","text_display":" study intervention (i.e. change in surgery type intraoperatively). Enrollment will be stopped once a total of","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[245,855],[1583,855],[1583,898],[245,898]],"region":{"top_left_x":244,"top_left_y":855,"width":1340,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00985f227d294b00af613f99d8b2b7f1","type":"text","conversion_output":true,"text":"120 randomized patients have undergone surgery and received the study medications.","text_display":" 120 randomized patients have undergone surgery and received the study medications.","confidence":1,"confidence_rate":1},{"cnt":[[241,928],[939,928],[939,982],[241,982]],"region":{"top_left_x":240,"top_left_y":928,"width":699,"height":54},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c516662cde884878af505f4054b90bb6","type":"section_header","conversion_output":false,"children_ids":["a73cbb80aa274cc38f7baf0f760d669a"],"text":"","text_display":""},{"cnt":[[245,937],[932,937],[932,978],[245,978]],"region":{"top_left_x":244,"top_left_y":936,"width":689,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a73cbb80aa274cc38f7baf0f760d669a","type":"text","conversion_output":true,"parent_id":"c516662cde884878af505f4054b90bb6","text":"General Approach to Statistical Analyses","text_display":"\n\n\\section*{General Approach to Statistical Analyses}","confidence":0.9975607387024183,"confidence_rate":0.9999457294473185},{"cnt":[[245,980],[1878,980],[1878,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":979,"width":1634,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"312ddcbc3cca4c8ba681b3e4de7446b0","type":"text","conversion_output":true,"text":"Baseline and demographic characteristics will be summarized and presented using descriptive statistics.","text_display":"\n\nBaseline and demographic characteristics will be summarized and presented using descriptive statistics.","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1880,1027],[1880,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1026,"width":1636,"height":47},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec0b64cdd89f4c11bada086727bb82b4","type":"text","conversion_output":true,"text":"Continuous data will be presented as means ± standard deviations or medians (interquartile range)","text_display":" Continuous data will be presented as means ± standard deviations or medians (interquartile range)","confidence":0.9580078125,"confidence_rate":0.9995795066082735},{"cnt":[[245,1074],[1880,1074],[1880,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1074,"width":1636,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2ae059208a04f79bb298bd313fa10de","type":"text","conversion_output":true,"text":"depending on the distribution of the data. The Shapiro-Wilk test will be utilized in order to determine whether","text_display":" depending on the distribution of the data. The Shapiro-Wilk test will be utilized in order to determine whether","confidence":0.9990236759185791,"confidence_rate":0.9999915793372107},{"cnt":[[245,1117],[1880,1117],[1880,1162],[245,1162]],"region":{"top_left_x":244,"top_left_y":1117,"width":1636,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b404308ce9340ef95ec7606cb31f45d","type":"text","conversion_output":true,"text":"or not the data follows a Gaussian distribution. Differences in continuous data between study groups will","text_display":" or not the data follows a Gaussian distribution. Differences in continuous data between study groups will","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[1880,1164],[1880,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1164,"width":1636,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1914aeaf00664ee1916df19345a9e2ef","type":"text","conversion_output":true,"text":"be assessed using a parametric t-tests or Wilcoxon Rank-Sum tests as appropriate. Categorical data will","text_display":" be assessed using a parametric t-tests or Wilcoxon Rank-Sum tests as appropriate. Categorical data will","confidence":1,"confidence_rate":1},{"cnt":[[245,1212],[1880,1212],[1880,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1211,"width":1636,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34dae8eca61a426da88dfd8701ad3880","type":"text","conversion_output":true,"text":"be presented as frequencies and proportions and assessed with a chi-square test. In the event that cell","text_display":" be presented as frequencies and proportions and assessed with a chi-square test. In the event that cell","confidence":1,"confidence_rate":1},{"cnt":[[245,1255],[1880,1255],[1880,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1254,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed4275ae56b44397a07b8f6976bd39e8","type":"text","conversion_output":true,"text":"counts are small (less than 5), we will employ the use of a Fisher's Exact test. For all analyses two-sided","text_display":" counts are small (less than 5), we will employ the use of a Fisher's Exact test. For all analyses two-sided","confidence":0.7578125,"confidence_rate":0.9975269978721842},{"cnt":[[245,1302],[1880,1302],[1880,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1301,"width":1636,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd638c2eb14443a083e43553ad51f5d2","type":"text","conversion_output":true,"text":"p-values less than 0.05 will be considered statistically significant. SAS 9.3 (SAS Institute Inc., Cary, NC)","text_display":" p-values less than 0.05 will be considered statistically significant. SAS 9.3 (SAS Institute Inc., Cary, NC)","confidence":0.9819502830505371,"confidence_rate":0.9998469478467228},{"cnt":[[245,1349],[836,1349],[836,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1349,"width":592,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27475b0337bf4478aefafdfae99ec917","type":"text","conversion_output":true,"text":"or later will be utilized for all analyses.","text_display":" or later will be utilized for all analyses.","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[1880,1427],[1880,1472],[245,1472]],"region":{"top_left_x":244,"top_left_y":1426,"width":1636,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b557d01e18404a86858d934853c40efe","type":"text","conversion_output":true,"text":"Analyses will be performed on a modified intention to treat basis, in which all patient who receive at least","text_display":"\n\nAnalyses will be performed on a modified intention to treat basis, in which all patient who receive at least","confidence":1,"confidence_rate":1},{"cnt":[[245,1474],[1210,1474],[1210,1519],[245,1519]],"region":{"top_left_x":244,"top_left_y":1473,"width":966,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5549cf1d64154409a4d6f0128ee115f9","type":"text","conversion_output":true,"text":"one dose of any of the four study medications will be included.","text_display":" one dose of any of the four study medications will be included.","confidence":1,"confidence_rate":1},{"cnt":[[236,1560],[1081,1560],[1081,1618],[236,1618]],"region":{"top_left_x":236,"top_left_y":1559,"width":845,"height":59},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42ebd04a074a469eac872b23ff96263b","type":"section_header","conversion_output":false,"children_ids":["eb7a21706c4f4a4ea1139e26801280e8"],"text":"","text_display":""},{"cnt":[[245,1566],[1076,1566],[1076,1611],[245,1611]],"region":{"top_left_x":244,"top_left_y":1566,"width":833,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb7a21706c4f4a4ea1139e26801280e8","type":"text","conversion_output":true,"parent_id":"42ebd04a074a469eac872b23ff96263b","text":"Analysis of the Primary and Secondary Outcomes","text_display":"\n\n\\section*{Analysis of the Primary and Secondary Outcomes}","confidence":1,"confidence_rate":1},{"cnt":[[245,1611],[1880,1611],[1880,1656],[245,1656]],"region":{"top_left_x":244,"top_left_y":1611,"width":1636,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4132d3b0ea7844599fe4d18af1154633","type":"text","conversion_output":true,"text":"The DEXACET trial has been designed as a factorial, randomized controlled trial with four treatment groups.","text_display":"\n\nThe DEXACET trial has been designed as a factorial, randomized controlled trial with four treatment groups.","confidence":1,"confidence_rate":1},{"cnt":[[245,1659],[1880,1659],[1880,1704],[245,1704]],"region":{"top_left_x":244,"top_left_y":1658,"width":1636,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb3ca99bab994829809ac9fa5d904c9d","type":"text","conversion_output":true,"text":"We will therefore aim to test 1) the effect of acetaminophen versus placebo and 2) the effect of","text_display":" We will therefore aim to test 1) the effect of acetaminophen versus placebo and 2) the effect of","confidence":0.7901413440704346,"confidence_rate":0.997670604065431},{"cnt":[[245,1704],[1880,1704],[1880,1749],[245,1749]],"region":{"top_left_x":244,"top_left_y":1703,"width":1636,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48e232d2bb4544a6aa7c327fa81790fa","type":"text","conversion_output":true,"text":"dexmedetomidine in comparison to propofol in the event that there is no interaction between treatment","text_display":" dexmedetomidine in comparison to propofol in the event that there is no interaction between treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1749],[1880,1749],[1880,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1748,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f5007974fd7454ba2ed8cbc1bf526f7","type":"text","conversion_output":true,"text":"effects. However, the first of these (the effect of acetaminophen) is considered the most interesting and","text_display":" effects. However, the first of these (the effect of acetaminophen) is considered the most interesting and","confidence":1,"confidence_rate":1},{"cnt":[[245,1796],[1641,1796],[1641,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1796,"width":1398,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e5aa136e8744d00aa85dc9b04303a58","type":"text","conversion_output":true,"text":"the study has been powered to answer this question using an unadjusted chi-squared test.","text_display":" the study has been powered to answer this question using an unadjusted chi-squared test.","confidence":1,"confidence_rate":1},{"cnt":[[245,1878],[1880,1878],[1880,1923],[245,1923]],"region":{"top_left_x":244,"top_left_y":1877,"width":1636,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f4294099cdf40cf86e6f28164e1cb21","type":"text","conversion_output":true,"text":"To test whether or not there is an interaction we will compose a logistic regression model include indicator","text_display":"\n\nTo test whether or not there is an interaction we will compose a logistic regression model include indicator","confidence":1,"confidence_rate":1},{"cnt":[[245,1921],[1880,1921],[1880,1966],[245,1966]],"region":{"top_left_x":244,"top_left_y":1920,"width":1636,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"056b0fd50deb4be398c203e0cc9cc780","type":"text","conversion_output":true,"text":"variables for the acetaminophen group as well as the dexmedetomidine group. We will further include an","text_display":" variables for the acetaminophen group as well as the dexmedetomidine group. We will further include an","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1880,1968],[1880,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1967,"width":1636,"height":47},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45b37a476c724a60a8ff0d19cbd99a53","type":"text","conversion_output":true,"text":"interaction term in this model composed of the indicator variables multiplied together. If there is a significant","text_display":" interaction term in this model composed of the indicator variables multiplied together. If there is a significant","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1880,2015],[1880,2058],[245,2058]],"region":{"top_left_x":244,"top_left_y":2015,"width":1636,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3943d8e906bb486dafaff01c4ede9c32","type":"text","conversion_output":true,"text":"interaction between groups when assessing the incidence of in-hospital delirium, we will interpret the results","text_display":" interaction between groups when assessing the incidence of in-hospital delirium, we will interpret the results","confidence":1,"confidence_rate":1},{"cnt":[[245,2058],[1880,2058],[1880,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2058,"width":1636,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e062b400b02643b7b1c8ff7fe0d75ee9","type":"text","conversion_output":true,"text":"stratified by all four groups, presenting the main effects only after taking into account the other factor, in a","text_display":" stratified by all four groups, presenting the main effects only after taking into account the other factor, in a","confidence":1,"confidence_rate":1},{"cnt":[[247,2105],[1880,2105],[1880,2151],[247,2151]],"region":{"top_left_x":247,"top_left_y":2105,"width":1633,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f8fb005d7124aaaa5d42f69b5bd220d","type":"text","conversion_output":true,"text":"'inside the table analysis'. If the interaction term is not significant we will present the main effects by pooling","text_display":" 'inside the table analysis'. If the interaction term is not significant we will present the main effects by pooling","confidence":0.80810546875,"confidence_rate":0.998226052821345},{"cnt":[[245,2153],[685,2153],[685,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2152,"width":442,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4978ec2d5edd45dc8519d2660cf4b8d8","type":"text","conversion_output":true,"text":"data across the other factor.","text_display":" data across the other factor.","confidence":1,"confidence_rate":1},{"cnt":[[245,2230],[1880,2230],[1880,2277],[245,2277]],"region":{"top_left_x":244,"top_left_y":2230,"width":1636,"height":48},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b59d65d58c8e4d63b9b3df032c6abbce","type":"text","conversion_output":true,"text":"Kaplan Meier curves and a Cox proportional hazards model was used to compare time to experiencing","text_display":"\n\nKaplan Meier curves and a Cox proportional hazards model was used to compare time to experiencing","confidence":1,"confidence_rate":1},{"cnt":[[245,2277],[1880,2277],[1880,2322],[245,2322]],"region":{"top_left_x":244,"top_left_y":2277,"width":1636,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e446553f804e4d8489e459a8df254715","type":"text","conversion_output":true,"text":"delirium, after confirming the proportional hazards assumption is met. To test whether the Proportional","text_display":" delirium, after confirming the proportional hazards assumption is met. To test whether the Proportional","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caddfefb9d3545bb9256d7087e5512da","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-15","page":15,"lines":[{"cnt":[[245,125],[1721,125],[1721,170],[245,170]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4de103ac26ee406fba840a22b2913609","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a43a15c1cd224747bae7af6e52ad147a","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68ab2e7e67b143d4b394c74eba11ce5e","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1880,249],[1880,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":1636,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ccec0e507eb4829a11b0c68075c1831","type":"text","conversion_output":true,"text":"Hazards (PH) assumption holds, we will include a time varying covariate with group in the model. Given","text_display":"\nHazards (PH) assumption holds, we will include a time varying covariate with group in the model. Given","confidence":0.9980475902557373,"confidence_rate":0.9999817355109043},{"cnt":[[245,296],[1880,296],[1880,342],[245,342]],"region":{"top_left_x":244,"top_left_y":296,"width":1636,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"827d310a0bb4408a94de27cd6654e13f","type":"text","conversion_output":true,"text":"the factorial design this approach will be replicated in models for all four factorial groups, as well as the","text_display":" the factorial design this approach will be replicated in models for all four factorial groups, as well as the","confidence":1,"confidence_rate":1},{"cnt":[[245,339],[1880,339],[1880,389],[245,389]],"region":{"top_left_x":244,"top_left_y":339,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4aa3ad217d14d89831eb1b43a23136d","type":"text","conversion_output":true,"text":"pairwise comparisons (dexmedetomidine vs propofol; acetaminophen vs placebo) to ensure this","text_display":" pairwise comparisons (dexmedetomidine vs propofol; acetaminophen vs placebo) to ensure this","confidence":1,"confidence_rate":1},{"cnt":[[245,387],[1880,387],[1880,434],[245,434]],"region":{"top_left_x":244,"top_left_y":386,"width":1636,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"793e18fe13184ba18268be736251da7f","type":"text","conversion_output":true,"text":"assumption remains valid. In the event that this assumption is not valid, we will include a time-varying","text_display":" assumption remains valid. In the event that this assumption is not valid, we will include a time-varying","confidence":1,"confidence_rate":1},{"cnt":[[245,434],[1815,434],[1815,479],[245,479]],"region":{"top_left_x":244,"top_left_y":433,"width":1572,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46825e2c9250445b81abe6366736b862","type":"text","conversion_output":true,"text":"covariate in the model. Hazards ratios and their associated \\(95 \\%\\) confidence intervals will be reported.","text_display":" covariate in the model. Hazards ratios and their associated \\(95 \\%\\) confidence intervals will be reported.","confidence":0.9990236759185791,"confidence_rate":0.9999911200303706},{"cnt":[[245,511],[1880,511],[1880,561],[245,561]],"region":{"top_left_x":244,"top_left_y":511,"width":1636,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42393813c3284632b01d4672c8d91f1d","type":"text","conversion_output":true,"text":"Repeated measures analyses including generalized estimating equations with robust variance will be","text_display":"\n\nRepeated measures analyses including generalized estimating equations with robust variance will be","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1880,559],[1880,604],[245,604]],"region":{"top_left_x":244,"top_left_y":558,"width":1636,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e351d62e1d5749da96647467ee4b4d41","type":"text","conversion_output":true,"text":"employed to assess for differences in continuous variables that are measured at multiple time points over","text_display":" employed to assess for differences in continuous variables that are measured at multiple time points over","confidence":1,"confidence_rate":1},{"cnt":[[245,606],[1055,606],[1055,651],[245,651]],"region":{"top_left_x":244,"top_left_y":605,"width":811,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc2118527c3e450bb445396406de6ffc","type":"text","conversion_output":true,"text":"time between groups using mixed model regression.","text_display":" time between groups using mixed model regression.","confidence":1,"confidence_rate":1},{"cnt":[[245,688],[1878,688],[1878,733],[245,733]],"region":{"top_left_x":244,"top_left_y":687,"width":1634,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c743b88ac3734f2bad34badb349b016e","type":"text","conversion_output":true,"text":"Interrater reliability assessments of delirium will be assessed for approximately \\(10 \\%\\) of patients. This","text_display":"\n\nInterrater reliability assessments of delirium will be assessed for approximately \\(10 \\%\\) of patients. This","confidence":0.99609375,"confidence_rate":0.9999647402673945},{"cnt":[[245,733],[1878,733],[1878,778],[245,778]],"region":{"top_left_x":244,"top_left_y":732,"width":1634,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2157d42511ec4066bc668b3d201b0eff","type":"text","conversion_output":true,"text":"includes assessment of both for the presence of delirium, and for key features including acute change,","text_display":" includes assessment of both for the presence of delirium, and for key features including acute change,","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1878,778],[1878,823],[245,823]],"region":{"top_left_x":244,"top_left_y":777,"width":1634,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09b1631df519415dadb3b2a9f534e19f","type":"text","conversion_output":true,"text":"inattention, disorganized thinking and an altered level of consciousness. Percent agreement, kappa and","text_display":" inattention, disorganized thinking and an altered level of consciousness. Percent agreement, kappa and","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[750,825],[750,870],[245,870]],"region":{"top_left_x":244,"top_left_y":825,"width":506,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbc971a4dab748328d11038fbaf2ae21","type":"text","conversion_output":true,"text":"weighted kappa will be reported.","text_display":" weighted kappa will be reported.","confidence":1,"confidence_rate":1},{"cnt":[[245,904],[1878,904],[1878,950],[245,950]],"region":{"top_left_x":244,"top_left_y":904,"width":1634,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd0bb62a0d97432497c7272be4636410","type":"text","conversion_output":true,"text":"Given the nature of a randomized controlled trial, we do not anticipate seeing differences between groups","text_display":"\n\nGiven the nature of a randomized controlled trial, we do not anticipate seeing differences between groups","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[245,945],[1878,945],[1878,990],[245,990]],"region":{"top_left_x":244,"top_left_y":945,"width":1634,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c9f35978bcd45f6923f4196c4f23c79","type":"text","conversion_output":true,"text":"in baseline characteristics; however, we will perform a secondary analysis, adjusting for any differences","text_display":" in baseline characteristics; however, we will perform a secondary analysis, adjusting for any differences","confidence":1,"confidence_rate":1},{"cnt":[[245,986],[1880,986],[1880,1029],[245,1029]],"region":{"top_left_x":244,"top_left_y":986,"width":1636,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32643fb36b39438aafe0741c0fbe6ba6","type":"text","conversion_output":true,"text":"observed between groups and presenting adjusted odds ratios and their associated \\(95 \\%\\) confidence","text_display":" observed between groups and presenting adjusted odds ratios and their associated \\(95 \\%\\) confidence","confidence":0.99169921875,"confidence_rate":0.9999190768222336},{"cnt":[[245,1027],[393,1027],[393,1063],[245,1063]],"region":{"top_left_x":244,"top_left_y":1026,"width":150,"height":38},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47668000e72a403b8e5eac5d45a8d7c1","type":"text","conversion_output":true,"text":"intervals.","text_display":" intervals.","confidence":1,"confidence_rate":1},{"cnt":[[241,1102],[537,1102],[537,1154],[241,1154]],"region":{"top_left_x":240,"top_left_y":1102,"width":298,"height":52},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa7a00a5f4394b83ac98f5244a571a9a","type":"section_header","conversion_output":false,"children_ids":["694ae3702a674ac2a71867f21680c64a"],"text":"","text_display":""},{"cnt":[[245,1109],[531,1109],[531,1149],[245,1149]],"region":{"top_left_x":244,"top_left_y":1108,"width":287,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"694ae3702a674ac2a71867f21680c64a","type":"text","conversion_output":true,"parent_id":"fa7a00a5f4394b83ac98f5244a571a9a","text":"Interim Analyses","text_display":"\n\n\\section*{Interim Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,1154],[758,1154],[758,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1153,"width":515,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bde9c0894e4b402a891163e4ca62962c","type":"text","conversion_output":true,"text":"There will be no interim analysis.","text_display":"\n\nThere will be no interim analysis.","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[241,1229],[473,1229],[473,1283],[241,1283]],"region":{"top_left_x":240,"top_left_y":1228,"width":233,"height":55},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c344d85d07304d03bfe4f0ac5a51aed1","type":"section_header","conversion_output":false,"children_ids":["691063ad2a854cf199d912d6c1668391"],"text":"","text_display":""},{"cnt":[[245,1233],[468,1233],[468,1278],[245,1278]],"region":{"top_left_x":244,"top_left_y":1233,"width":225,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"691063ad2a854cf199d912d6c1668391","type":"text","conversion_output":true,"parent_id":"c344d85d07304d03bfe4f0ac5a51aed1","text":"Missing Data","text_display":"\n\n\\section*{Missing Data}","confidence":1,"confidence_rate":1},{"cnt":[[245,1280],[1878,1280],[1878,1326],[245,1326]],"region":{"top_left_x":244,"top_left_y":1280,"width":1634,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cd07187ddff472da4dd32422c434235","type":"text","conversion_output":true,"text":"The frequency and percentage of missing values for each variable will be collected, analyzed and reported","text_display":"\n\nThe frequency and percentage of missing values for each variable will be collected, analyzed and reported","confidence":1,"confidence_rate":1},{"cnt":[[245,1326],[1876,1326],[1876,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1325,"width":1632,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb0d6c4816574e2d901c1ff92ba51df3","type":"text","conversion_output":true,"text":"as necessary. If there are missing values for the outcome variable(s), individual patients will be excluded.","text_display":" as necessary. If there are missing values for the outcome variable(s), individual patients will be excluded.","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[1880,1371],[1880,1416],[245,1416]],"region":{"top_left_x":244,"top_left_y":1370,"width":1636,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69b7fcea94d14121b1bdbefdff89b114","type":"text","conversion_output":true,"text":"Highly incomplete covariates (>33\\% of observations missing) will be excluded from analyses. In the event","text_display":" Highly incomplete covariates (>33\\% of observations missing) will be excluded from analyses. In the event","confidence":0.9970715045928955,"confidence_rate":0.9999730940148176},{"cnt":[[245,1418],[1880,1418],[1880,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1417,"width":1636,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b78703aa2b3849ee85dbcc94e1714aa6","type":"text","conversion_output":true,"text":"that a variable is missing more than \\(10 \\%\\) of the time we will consider imputation. If missing values are","text_display":" that a variable is missing more than \\(10 \\%\\) of the time we will consider imputation. If missing values are","confidence":0.9951171875,"confidence_rate":0.9999559039238215},{"cnt":[[245,1463],[1878,1463],[1878,1508],[245,1508]],"region":{"top_left_x":244,"top_left_y":1463,"width":1634,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3279792b066043d09629af4ad8a4d039","type":"text","conversion_output":true,"text":"missing at random (MAR) or not at random (MNAR), multiple imputation will be performed. Missing values,","text_display":" missing at random (MAR) or not at random (MNAR), multiple imputation will be performed. Missing values,","confidence":1,"confidence_rate":1},{"cnt":[[245,1508],[1878,1508],[1878,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1508,"width":1634,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb9ffb0e8bb2457db85b2a5d5a12e679","type":"text","conversion_output":true,"text":"selection or exclusion of observations and variables and handling of missing values in the statistical analysis","text_display":" selection or exclusion of observations and variables and handling of missing values in the statistical analysis","confidence":1,"confidence_rate":1},{"cnt":[[245,1555],[1540,1555],[1540,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1555,"width":1297,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f63b1febcd048dbba82dc603e385c9a","type":"text","conversion_output":true,"text":"will be describes carefully and sensitivity analysis will be provided in the manuscript.","text_display":" will be describes carefully and sensitivity analysis will be provided in the manuscript.","confidence":1,"confidence_rate":1},{"cnt":[[241,1629],[715,1629],[715,1687],[241,1687]],"region":{"top_left_x":240,"top_left_y":1628,"width":476,"height":59},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e109322ed964cfcb56d5fe2d0c916ad","type":"section_header","conversion_output":false,"children_ids":["f6af3606c659486c82f9ad214d5677ed"],"text":"","text_display":""},{"cnt":[[245,1637],[707,1637],[707,1680],[245,1680]],"region":{"top_left_x":244,"top_left_y":1637,"width":463,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6af3606c659486c82f9ad214d5677ed","type":"text","conversion_output":true,"parent_id":"2e109322ed964cfcb56d5fe2d0c916ad","text":"Statistical Analytical Issues","text_display":"\n\n\\section*{Statistical Analytical Issues}","confidence":1,"confidence_rate":1},{"cnt":[[241,1678],[677,1678],[677,1729],[241,1729]],"region":{"top_left_x":240,"top_left_y":1677,"width":437,"height":53},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4fa9484216b4c7981ac2b4e0afa3097","type":"section_header","conversion_output":false,"children_ids":["c05585ec2c7a4af5ae65dae82a1ac1b8"],"text":"","text_display":""},{"cnt":[[245,1684],[672,1684],[672,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1684,"width":429,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c05585ec2c7a4af5ae65dae82a1ac1b8","type":"text","conversion_output":true,"parent_id":"a4fa9484216b4c7981ac2b4e0afa3097","text":"Adjustments for Covariates","text_display":"\n\n\\section*{Adjustments for Covariates}","confidence":1,"confidence_rate":1},{"cnt":[[245,1727],[1882,1727],[1882,1772],[245,1772]],"region":{"top_left_x":244,"top_left_y":1727,"width":1639,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb156f9b331f4b7fa6f1c601ae542f08","type":"text","conversion_output":true,"text":"Given the randomized nature of this study, there will be no covariate adjustment in the primary analysis. If","text_display":"\n\nGiven the randomized nature of this study, there will be no covariate adjustment in the primary analysis. If","confidence":1,"confidence_rate":1},{"cnt":[[245,1766],[1880,1766],[1880,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1766,"width":1636,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2769ccb9cd4c4a6c8a3e49caeb25f8c9","type":"text","conversion_output":true,"text":"differences between groups persist after randomization we will perform a post hoc analysis including","text_display":" differences between groups persist after randomization we will perform a post hoc analysis including","confidence":1,"confidence_rate":1},{"cnt":[[245,1809],[1059,1809],[1059,1850],[245,1850]],"region":{"top_left_x":244,"top_left_y":1808,"width":816,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4427db2ae554c6ab4ffbdeb11b9fcb5","type":"text","conversion_output":true,"text":"variables that are significantly differ between groups.","text_display":" variables that are significantly differ between groups.","confidence":0.99951171875,"confidence_rate":0.999991860024828},{"cnt":[[241,1886],[595,1886],[595,1938],[241,1938]],"region":{"top_left_x":240,"top_left_y":1886,"width":356,"height":52},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f89d47c36f85445e9beb7790e6d6beba","type":"section_header","conversion_output":false,"children_ids":["5ced4d48d4824e3a8150afbdd7e5a236"],"text":"","text_display":""},{"cnt":[[245,1891],[587,1891],[587,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1890,"width":343,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ced4d48d4824e3a8150afbdd7e5a236","type":"text","conversion_output":true,"parent_id":"f89d47c36f85445e9beb7790e6d6beba","text":"Multiple Comparisons","text_display":"\n\n\\section*{Multiple Comparisons}","confidence":1,"confidence_rate":1},{"cnt":[[245,1936],[1880,1936],[1880,1979],[245,1979]],"region":{"top_left_x":244,"top_left_y":1935,"width":1636,"height":44},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"534a3d2c83194186bb82b0b8779f07a6","type":"text","conversion_output":true,"text":"There will be no adjustment for multiple testing. Results of secondary outcomes and post hoc analyses will","text_display":"\n\nThere will be no adjustment for multiple testing. Results of secondary outcomes and post hoc analyses will","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[245,1977],[810,1977],[810,2020],[245,2020]],"region":{"top_left_x":244,"top_left_y":1976,"width":566,"height":44},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2205f5dd3e584a63ad0552b25ce75494","type":"text","conversion_output":true,"text":"therefore be considered exploratory.","text_display":" therefore be considered exploratory.","confidence":1,"confidence_rate":1},{"cnt":[[240,2052],[700,2050],[701,2103],[241,2106]],"region":{"top_left_x":240,"top_left_y":2049,"width":461,"height":57},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8a915fbbbc747ca94c56e266a453682","type":"section_header","conversion_output":false,"children_ids":["326ebd0f8570488bbefd7e8744dbe65f"],"text":"","text_display":""},{"cnt":[[245,2058],[694,2058],[694,2099],[245,2099]],"region":{"top_left_x":244,"top_left_y":2058,"width":450,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"326ebd0f8570488bbefd7e8744dbe65f","type":"text","conversion_output":true,"parent_id":"e8a915fbbbc747ca94c56e266a453682","text":"Examination of Subgroups","text_display":"\n\n\\section*{Examination of Subgroups}","confidence":0.9931640625,"confidence_rate":0.9997634966075137},{"cnt":[[245,2101],[1878,2101],[1878,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2101,"width":1634,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44f2ee72062c4f9e8cd7cdf3c0807c58","type":"text","conversion_output":true,"text":"Our pre-specified primary analysis will assess the incidence of delirium between patients receiving","text_display":"\n\nOur pre-specified primary analysis will assess the incidence of delirium between patients receiving","confidence":1,"confidence_rate":1},{"cnt":[[245,2148],[1880,2148],[1880,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2148,"width":1636,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ec42d8e972d40198e8a15e7f72384cd","type":"text","conversion_output":true,"text":"intravenous acetaminophen versus placebo. Predefined subgroup analyses will be performed for our","text_display":" intravenous acetaminophen versus placebo. Predefined subgroup analyses will be performed for our","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1145,2196],[1145,2239],[245,2239]],"region":{"top_left_x":244,"top_left_y":2195,"width":902,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94ea5c152620479298cdcddca298a935","type":"text","conversion_output":true,"text":"primary and secondary outcomes for the following groups:","text_display":" primary and secondary outcomes for the following groups:","confidence":1,"confidence_rate":1},{"cnt":[[309,2243],[1240,2243],[1240,2288],[309,2288]],"region":{"top_left_x":309,"top_left_y":2242,"width":931,"height":47},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbcd309dd4e2479da029e42debf0394b","type":"text","conversion_output":true,"text":"- Two sedative groups: dexmedetomidine versus propofol","text_display":"\n- Two sedative groups: dexmedetomidine versus propofol","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbe32fa8eef04e6f8542ee48229b6b4f","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-16","page":16,"lines":[{"cnt":[[245,125],[1721,125],[1721,170],[245,170]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e83b4178b1344eda1f5b629618ad113","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7276c5ea5b24219952917f61ac82175","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb369eecbe81459f8136de6003eac672","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[305,254],[1880,254],[1880,299],[305,299]],"region":{"top_left_x":305,"top_left_y":253,"width":1575,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c26306f787d34ab2bf74564f995520a3","type":"text","conversion_output":true,"text":"- All four factorial groups including both sedatives (dexmedetomidine and propofol) and analgesics","text_display":"\n- All four factorial groups including both sedatives (dexmedetomidine and propofol) and analgesics","confidence":1,"confidence_rate":1},{"cnt":[[370,296],[849,296],[849,346],[370,346]],"region":{"top_left_x":369,"top_left_y":296,"width":480,"height":50},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff1ab0ee60944caeadb37e897c69e2ab","type":"text","conversion_output":true,"text":"(acetaminophen and placebo).","text_display":" (acetaminophen and placebo).","confidence":1,"confidence_rate":1},{"cnt":[[241,374],[569,374],[569,428],[241,428]],"region":{"top_left_x":240,"top_left_y":373,"width":330,"height":55},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e24c02f2d1ad485e8695969d244c37de","type":"section_header","conversion_output":false,"children_ids":["e83f45eb73bb43f2982b93a6889ed60b"],"text":"","text_display":""},{"cnt":[[245,378],[565,378],[565,423],[245,423]],"region":{"top_left_x":244,"top_left_y":378,"width":322,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e83f45eb73bb43f2982b93a6889ed60b","type":"text","conversion_output":true,"parent_id":"e24c02f2d1ad485e8695969d244c37de","text":"Post-hoc Analyses","text_display":"\n\n\\section*{Post-hoc Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[245,425],[1442,425],[1442,471],[245,471]],"region":{"top_left_x":244,"top_left_y":425,"width":1198,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7d63f48fc824726bc8d60ec362e4d3f","type":"text","conversion_output":true,"text":"Post-hoc data driven analyses are allowed after the following are undertaken:","text_display":"\n\nPost-hoc data driven analyses are allowed after the following are undertaken:","confidence":1,"confidence_rate":1},{"cnt":[[309,486],[1854,486],[1854,535],[309,535]],"region":{"top_left_x":309,"top_left_y":485,"width":1546,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b24c649f594d4f748d2ae3a3faccb1c2","type":"text","conversion_output":true,"text":"(a) Document which analyses were conducted after the results for the Primary and Secondary Aims","text_display":"\n(a) Document which analyses were conducted after the results for the Primary and Secondary Aims","confidence":1,"confidence_rate":1},{"cnt":[[370,529],[587,529],[587,574],[370,574]],"region":{"top_left_x":369,"top_left_y":528,"width":218,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed1dd39599054972a90ad6e53ff55754","type":"text","conversion_output":true,"text":"are analyzed.","text_display":" are analyzed.","confidence":1,"confidence_rate":1},{"cnt":[[309,571],[1038,571],[1038,617],[309,617]],"region":{"top_left_x":309,"top_left_y":571,"width":729,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbf39d2ac2b64025bbaf5155d22d5112","type":"text","conversion_output":true,"text":"(b) Document the rationale for these analyses.","text_display":"\n(b) Document the rationale for these analyses.","confidence":1,"confidence_rate":1},{"cnt":[[309,612],[1777,612],[1777,660],[309,660]],"region":{"top_left_x":309,"top_left_y":612,"width":1468,"height":48},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8bc74fbd7fa43a78fd4195036da63ee","type":"text","conversion_output":true,"text":"(c) Pre-specify their interpretation in the context of the primary and secondary results and their","text_display":"\n(c) Pre-specify their interpretation in the context of the primary and secondary results and their","confidence":1,"confidence_rate":1},{"cnt":[[370,655],[965,655],[965,700],[370,700]],"region":{"top_left_x":369,"top_left_y":655,"width":596,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4da7e61657549a2bd4fdb6f4c1da718","type":"text","conversion_output":true,"text":"impact on the overall trial conclusions.","text_display":" impact on the overall trial conclusions.","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3acc6694487b40f0b2ed3c0dca89b1c6","type":"page_info","conversion_output":false,"text":"16","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-17","page":17,"lines":[{"cnt":[[247,125],[1721,125],[1721,168],[247,168]],"region":{"top_left_x":247,"top_left_y":124,"width":1474,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c7cff0a4a73419398b73f84e8d9ceda","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7405ac990694c07b509fa6fd54ae5c6","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,249],[245,249]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02d75af6b60f466f9128051364d286f2","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[245,249],[1699,249],[1699,294],[245,294]],"region":{"top_left_x":244,"top_left_y":249,"width":1456,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d87c8a0637e54d34b0256de5546154c1","type":"text","conversion_output":true,"text":"eAPPENDIX 2. FAST TRACK PROTOCOL AND INTRAVENOUS DRUG ADMINISTRATION","text_display":"\neAPPENDIX 2. FAST TRACK PROTOCOL AND INTRAVENOUS DRUG ADMINISTRATION","confidence":1,"confidence_rate":1},{"cnt":[[245,296],[466,296],[466,337],[245,337]],"region":{"top_left_x":244,"top_left_y":296,"width":223,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5de5c393ed34675ad3b85d6f49a3881","type":"text","conversion_output":true,"text":"GUIDELINES","text_display":" GUIDELINES","confidence":1,"confidence_rate":1},{"cnt":[[621,400],[1506,400],[1506,455],[621,455]],"region":{"top_left_x":620,"top_left_y":399,"width":887,"height":57},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0573e8b3d92a4c9293e9873d38a59254","type":"section_header","conversion_output":false,"children_ids":["04f1e60f637b435da8afa47686566268"],"text":"","text_display":""},{"cnt":[[627,404],[1500,404],[1500,449],[627,449]],"region":{"top_left_x":627,"top_left_y":403,"width":873,"height":47},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04f1e60f637b435da8afa47686566268","type":"text","conversion_output":true,"parent_id":"0573e8b3d92a4c9293e9873d38a59254","text":"FAST TRACK PROTOCOL FOR CARDIAC SURGERY","text_display":"\n\n\\section*{FAST TRACK PROTOCOL FOR CARDIAC SURGERY}","confidence":1,"confidence_rate":1},{"cnt":[[367,487],[732,487],[732,599],[367,599]],"region":{"top_left_x":367,"top_left_y":487,"width":365,"height":112},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"859cba4666b140ceb3d9043ec91bf198","type":"column","conversion_output":false,"children_ids":["b3a060c0ad7b448f81bb0d5bd57a5eed","16760115ef2246ffbbdca26d3ed7726a"],"text":"","text_display":""},{"cnt":[[370,490],[518,490],[518,526],[370,526]],"region":{"top_left_x":369,"top_left_y":489,"width":149,"height":38},"line":9,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3a060c0ad7b448f81bb0d5bd57a5eed","type":"text","conversion_output":true,"parent_id":"859cba4666b140ceb3d9043ec91bf198","text":"Version:","text_display":"\n\nVersion:","confidence":1,"confidence_rate":1},{"cnt":[[370,554],[728,554],[728,595],[370,595]],"region":{"top_left_x":369,"top_left_y":554,"width":360,"height":42},"line":10,"column":1,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16760115ef2246ffbbdca26d3ed7726a","type":"text","conversion_output":true,"parent_id":"859cba4666b140ceb3d9043ec91bf198","text":"Institutional Authors:","text_display":"\nInstitutional Authors:","confidence":1,"confidence_rate":1},{"cnt":[[994,483],[1883,483],[1883,646],[994,646]],"region":{"top_left_x":994,"top_left_y":483,"width":889,"height":163},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d100894e8594aa0ba494f7b4842e6f0","type":"column","conversion_output":false,"children_ids":["70d3c1ccc9124ec6be49a273146ac127","150f272695174e41bbf06cf221888924","118ecd00b2c04505ac708803688db8e8"],"text":"","text_display":""},{"cnt":[[997,486],[1132,486],[1132,526],[997,526]],"region":{"top_left_x":996,"top_left_y":485,"width":137,"height":42},"line":12,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70d3c1ccc9124ec6be49a273146ac127","type":"text","conversion_output":true,"parent_id":"3d100894e8594aa0ba494f7b4842e6f0","text":"12/2015","text_display":"\n\n12/2015","confidence":1,"confidence_rate":1},{"cnt":[[997,554],[1880,554],[1880,599],[997,599]],"region":{"top_left_x":996,"top_left_y":554,"width":884,"height":46},"line":13,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"150f272695174e41bbf06cf221888924","type":"text","conversion_output":true,"parent_id":"3d100894e8594aa0ba494f7b4842e6f0","text":"BIDMC Perioperative Cardiovascular Intensive Care Unit","text_display":"\nBIDMC Perioperative Cardiovascular Intensive Care Unit","confidence":1,"confidence_rate":1},{"cnt":[[997,602],[1173,602],[1173,642],[997,642]],"region":{"top_left_x":996,"top_left_y":601,"width":178,"height":42},"line":14,"column":2,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"118ecd00b2c04505ac708803688db8e8","type":"text","conversion_output":true,"parent_id":"3d100894e8594aa0ba494f7b4842e6f0","text":"Committee","text_display":" Committee","confidence":1,"confidence_rate":1},{"cnt":[[241,722],[1205,722],[1205,780],[241,780]],"region":{"top_left_x":240,"top_left_y":721,"width":966,"height":59},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d65db603449847f085b936c7a3fcb7e7","type":"section_header","conversion_output":false,"children_ids":["ac8f47fd10744a83a0e9a00f19ffb0e0"],"text":"","text_display":""},{"cnt":[[245,726],[1197,726],[1197,776],[245,776]],"region":{"top_left_x":244,"top_left_y":726,"width":953,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac8f47fd10744a83a0e9a00f19ffb0e0","type":"text","conversion_output":true,"parent_id":"d65db603449847f085b936c7a3fcb7e7","text":"Cardiac Surgery Fast Track Ventilator Weaning Guideline","text_display":"\n\n\\section*{Cardiac Surgery Fast Track Ventilator Weaning Guideline}","confidence":1,"confidence_rate":1},{"cnt":[[245,808],[1880,808],[1880,855],[245,855]],"region":{"top_left_x":244,"top_left_y":807,"width":1636,"height":49},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c43dd1b448f4c5f8bdc439b6e234815","type":"text","conversion_output":true,"text":"Purpose: Patients who have undergone an uncomplicated cardiac surgical procedure should be able to","text_display":"\n\nPurpose: Patients who have undergone an uncomplicated cardiac surgical procedure should be able to","confidence":1,"confidence_rate":1},{"cnt":[[245,855],[1880,855],[1880,900],[245,900]],"region":{"top_left_x":244,"top_left_y":855,"width":1636,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2855ffae5914401835979e5020c909c","type":"text","conversion_output":true,"text":"wean quickly from the ventilator, fostering a more rapid recovery. The fast track weaning guideline provides","text_display":" wean quickly from the ventilator, fostering a more rapid recovery. The fast track weaning guideline provides","confidence":1,"confidence_rate":1},{"cnt":[[245,902],[1583,902],[1583,947],[245,947]],"region":{"top_left_x":244,"top_left_y":902,"width":1340,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea70b5b94ed24a78a15a6ba9c84f0c7d","type":"text","conversion_output":true,"text":"a decision-making framework that will expedite the process of weaning most efficiently","text_display":" a decision-making framework that will expedite the process of weaning most efficiently","confidence":1,"confidence_rate":1},{"cnt":[[245,982],[1880,982],[1880,1027],[245,1027]],"region":{"top_left_x":244,"top_left_y":981,"width":1636,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2f05543f41542448efa880e85985ae3","type":"text","conversion_output":true,"text":"Patient Selection: Selection of patients for fast track ventilator weaning will be made at time of handoff in","text_display":"\n\nPatient Selection: Selection of patients for fast track ventilator weaning will be made at time of handoff in","confidence":1,"confidence_rate":1},{"cnt":[[245,1027],[1880,1027],[1880,1072],[245,1072]],"region":{"top_left_x":244,"top_left_y":1026,"width":1636,"height":47},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ebeff3daa67447289dbfa8d7dae12d9","type":"text","conversion_output":true,"text":"Cardiovascular Intensive Care Unit (CVICU). It is a collaborative decision by the healthcare team at which","text_display":" Cardiovascular Intensive Care Unit (CVICU). It is a collaborative decision by the healthcare team at which","confidence":0.9990236759185791,"confidence_rate":0.9999912000297451},{"cnt":[[245,1074],[827,1074],[827,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1074,"width":584,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71ab65fa132d410691fe7dc9357aadcd","type":"text","conversion_output":true,"text":"time an order is placed in the system.","text_display":" time an order is placed in the system.","confidence":1,"confidence_rate":1},{"cnt":[[241,1147],[700,1147],[700,1205],[241,1205]],"region":{"top_left_x":240,"top_left_y":1147,"width":461,"height":59},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec765f3134b2482ca00ec4ef2299b973","type":"section_header","conversion_output":false,"children_ids":["c23900939bd44f2f9878704e5f0f3af7"],"text":"","text_display":""},{"cnt":[[245,1154],[694,1154],[694,1201],[245,1201]],"region":{"top_left_x":244,"top_left_y":1153,"width":450,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c23900939bd44f2f9878704e5f0f3af7","type":"text","conversion_output":true,"parent_id":"ec765f3134b2482ca00ec4ef2299b973","text":"Ventilator Settings on Arrival","text_display":"\n\n\\section*{Ventilator Settings on Arrival}","confidence":0.9990236759185791,"confidence_rate":0.9999720917895494},{"cnt":[[245,1233],[1880,1233],[1880,1280],[245,1280]],"region":{"top_left_x":244,"top_left_y":1233,"width":1636,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef6f74eaf1184afc9da30d8d2022910d","type":"text","conversion_output":true,"text":"All patients are placed on: assist control positive end expiratory pressure (PEEP) 5, fraction of inspired","text_display":"\n\nAll patients are placed on: assist control positive end expiratory pressure (PEEP) 5, fraction of inspired","confidence":0.9990236759185791,"confidence_rate":0.9999912000297451},{"cnt":[[245,1280],[1882,1280],[1882,1328],[245,1328]],"region":{"top_left_x":244,"top_left_y":1280,"width":1639,"height":48},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f02bb7528bee4e05a6f21dfa752dd5c6","type":"text","conversion_output":true,"text":"oxygen (FiO2) \\(100 \\%\\), tidal volume (vT) \\(6-10 ml / kg\\) (ideal body weight) and respiratory rate \\(12-14\\) (or per","text_display":" oxygen (FiO2) \\(100 \\%\\), tidal volume (vT) \\(6-10 ml / kg\\) (ideal body weight) and respiratory rate \\(12-14\\) (or per","confidence":0.6598695268075971,"confidence_rate":0.9966259233245205},{"cnt":[[245,1326],[436,1326],[436,1373],[245,1373]],"region":{"top_left_x":244,"top_left_y":1325,"width":193,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae9cc02c2bc54934ace86456b28a60c9","type":"text","conversion_output":true,"text":"anesthesia)","text_display":" anesthesia)","confidence":1,"confidence_rate":1},{"cnt":[[241,1401],[879,1401],[879,1459],[241,1459]],"region":{"top_left_x":240,"top_left_y":1400,"width":639,"height":59},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cccfdefabb14f17a1372e145d7aa3cf","type":"section_header","conversion_output":false,"children_ids":["ddf4e9b9de924639ad462c2f3488e9a5"],"text":"","text_display":""},{"cnt":[[245,1405],[874,1405],[874,1454],[245,1454]],"region":{"top_left_x":244,"top_left_y":1405,"width":631,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddf4e9b9de924639ad462c2f3488e9a5","type":"text","conversion_output":true,"parent_id":"9cccfdefabb14f17a1372e145d7aa3cf","text":"Extubation Goal (4 hours for Fast Track)","text_display":"\n\n\\section*{Extubation Goal (4 hours for Fast Track)}","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[305,1489],[1081,1489],[1081,1532],[305,1532]],"region":{"top_left_x":305,"top_left_y":1488,"width":776,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6bdafb4af2e4b8f8858696470f7a539","type":"text","conversion_output":true,"text":"- Nurse will write time of arrival on White Board","text_display":"\n- Nurse will write time of arrival on White Board","confidence":1,"confidence_rate":1},{"cnt":[[434,1530],[1882,1530],[1882,1575],[434,1575]],"region":{"top_left_x":433,"top_left_y":1529,"width":1450,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6589a557ee0248dd996ea454ba4616b5","type":"text","conversion_output":true,"text":"- This allows all members of the team to know when 23 hours is up to prevent Society of","text_display":"\n- This allows all members of the team to know when 23 hours is up to prevent Society of","confidence":1,"confidence_rate":1},{"cnt":[[494,1573],[1452,1573],[1452,1618],[494,1618]],"region":{"top_left_x":494,"top_left_y":1572,"width":959,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec3bdfcd57ed4f049356654802ed8b1d","type":"text","conversion_output":true,"text":"Thoracic Surgeons (STS) designation of prolonged ventilation","text_display":" Thoracic Surgeons (STS) designation of prolonged ventilation","confidence":0.9970715045928955,"confidence_rate":0.9999548811434265},{"cnt":[[241,1684],[569,1684],[569,1738],[241,1738]],"region":{"top_left_x":240,"top_left_y":1684,"width":330,"height":55},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a01c0a76e21f48ac9edd3f117d1af9a8","type":"section_header","conversion_output":false,"children_ids":["20ec36a8e0bd4e91a0f77cfbd3c261ad"],"text":"","text_display":""},{"cnt":[[245,1693],[565,1693],[565,1732],[245,1732]],"region":{"top_left_x":244,"top_left_y":1692,"width":322,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20ec36a8e0bd4e91a0f77cfbd3c261ad","type":"text","conversion_output":true,"parent_id":"a01c0a76e21f48ac9edd3f117d1af9a8","text":"PRE-EXTUBATION","text_display":"\n\n\\section*{PRE-EXTUBATION}","confidence":1,"confidence_rate":1},{"cnt":[[281,1766],[535,1766],[535,1818],[281,1818]],"region":{"top_left_x":281,"top_left_y":1766,"width":254,"height":52},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c252da8b45c46b88a66821ecb1d8ea6","type":"section_header","conversion_output":false,"children_ids":["d89a8c199f4542faa571a8e689467b2e"],"text":"","text_display":""},{"cnt":[[288,1770],[531,1770],[531,1815],[288,1815]],"region":{"top_left_x":287,"top_left_y":1770,"width":244,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d89a8c199f4542faa571a8e689467b2e","type":"text","conversion_output":true,"parent_id":"6c252da8b45c46b88a66821ecb1d8ea6","text":"I. Hand Off","text_display":"\n\n\\section*{I. Hand Off}","confidence":0.99951171875,"confidence_rate":0.9999694754347522},{"cnt":[[370,1813],[1257,1813],[1257,1858],[370,1858]],"region":{"top_left_x":369,"top_left_y":1813,"width":888,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0cbf3fde9f1411ebe0cb75f6afdc8da","type":"text","conversion_output":true,"text":"- Patient designated as appropriate for fast track wean","text_display":"\n- Patient designated as appropriate for fast track wean","confidence":1,"confidence_rate":1},{"cnt":[[494,1856],[776,1856],[776,1895],[494,1895]],"region":{"top_left_x":494,"top_left_y":1856,"width":282,"height":39},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65fff039c9e646efa29d8bf6b4271704","type":"text","conversion_output":true,"text":"- CVICU Nurse","text_display":"\n- CVICU Nurse","confidence":1,"confidence_rate":1},{"cnt":[[494,1895],[741,1895],[741,1936],[494,1936]],"region":{"top_left_x":494,"top_left_y":1894,"width":248,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc0024e5503e47faa99689c88f04c17b","type":"text","conversion_output":true,"text":"- Anesthesia","text_display":"\n- Anesthesia","confidence":1,"confidence_rate":1},{"cnt":[[494,1934],[1096,1934],[1096,1979],[494,1979]],"region":{"top_left_x":494,"top_left_y":1933,"width":602,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"420e4862fd7349148c7a9ce4a85addf3","type":"text","conversion_output":true,"text":"- Intensive Care Unit (ICU) Provider","text_display":"\n- Intensive Care Unit (ICU) Provider","confidence":1,"confidence_rate":1},{"cnt":[[494,1972],[1098,1972],[1098,2017],[494,2017]],"region":{"top_left_x":494,"top_left_y":1972,"width":604,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76862d66cb5c4a74b80933eb9ea01deb","type":"text","conversion_output":true,"text":"- CVICU Respiratory Therapist (RT)","text_display":"\n- CVICU Respiratory Therapist (RT)","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[271,2045],[638,2045],[638,2103],[271,2103]],"region":{"top_left_x":270,"top_left_y":2045,"width":369,"height":59},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ebee44fc3f04cfbb36020170c818ac3","type":"section_header","conversion_output":false,"children_ids":["72e697367e6d4221aad62cf58f123c8f"],"text":"","text_display":""},{"cnt":[[277,2054],[634,2054],[634,2099],[277,2099]],"region":{"top_left_x":277,"top_left_y":2053,"width":357,"height":47},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72e697367e6d4221aad62cf58f123c8f","type":"text","conversion_output":true,"parent_id":"3ebee44fc3f04cfbb36020170c818ac3","text":"II. Difficult Airway","text_display":"\n\n\\section*{II. Difficult Airway}","confidence":1,"confidence_rate":1},{"cnt":[[370,2097],[1652,2097],[1652,2142],[370,2142]],"region":{"top_left_x":369,"top_left_y":2096,"width":1284,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2ce978612594c96aab5c3529f113850","type":"text","conversion_output":true,"text":"- ICU Provider, Intensivist, Registered Nurse (RN), and RT discuss plan in detail","text_display":"\n- ICU Provider, Intensivist, Registered Nurse (RN), and RT discuss plan in detail","confidence":1,"confidence_rate":1},{"cnt":[[494,2136],[1474,2136],[1474,2181],[494,2181]],"region":{"top_left_x":494,"top_left_y":2135,"width":980,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d95c7a052aff48599e38f0024104e670","type":"text","conversion_output":true,"text":"- Who needs to be notified when patient ready to extubated?","text_display":"\n- Who needs to be notified when patient ready to extubated?","confidence":1,"confidence_rate":1},{"cnt":[[494,2174],[1594,2174],[1594,2219],[494,2219]],"region":{"top_left_x":494,"top_left_y":2174,"width":1101,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"379385d5ef3447d6a92ad20a4a78751a","type":"text","conversion_output":true,"text":"- Does ICU Provider or Intensivist want to be present for extubation?","text_display":"\n- Does ICU Provider or Intensivist want to be present for extubation?","confidence":1,"confidence_rate":1},{"cnt":[[494,2213],[1386,2213],[1386,2262],[494,2262]],"region":{"top_left_x":494,"top_left_y":2212,"width":892,"height":51},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"532d997c820c44ca93bea129fedb4340","type":"text","conversion_output":true,"text":"- What additional equipment is needed at the bedside?","text_display":"\n- What additional equipment is needed at the bedside?","confidence":1,"confidence_rate":1},{"cnt":[[262,2288],[758,2288],[758,2348],[262,2348]],"region":{"top_left_x":262,"top_left_y":2288,"width":497,"height":61},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"107637420f6f41c993f7ac2092bcfab3","type":"section_header","conversion_output":false,"children_ids":["0b1bf7c287db4b72b956b1571d419cde"],"text":"","text_display":""},{"cnt":[[269,2295],[754,2295],[754,2340],[269,2340]],"region":{"top_left_x":268,"top_left_y":2294,"width":487,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b1bf7c287db4b72b956b1571d419cde","type":"text","conversion_output":true,"parent_id":"107637420f6f41c993f7ac2092bcfab3","text":"III. Rewarming Guidelines","text_display":"\n\n\\section*{III. Rewarming Guidelines}","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c87a3ad3084f4fa5b0ebb8d1381d4dd5","type":"page_info","conversion_output":false,"text":"18","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-18","page":18,"lines":[{"cnt":[[245,125],[1721,125],[1721,170],[245,170]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"996f8e5d1ce94fbca2a7cc747907e422","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23a7a18edead490c83cf4c89d47fff9c","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6671f17de014b5eb47164bb1ff5863b","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[370,254],[769,254],[769,294],[370,294]],"region":{"top_left_x":369,"top_left_y":253,"width":401,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcbe9e51839b4f918864f7cdc2d63f1e","type":"text","conversion_output":true,"text":"- All Patients on arrival","text_display":"\n- All Patients on arrival","confidence":1,"confidence_rate":1},{"cnt":[[494,296],[1274,296],[1274,342],[494,342]],"region":{"top_left_x":494,"top_left_y":296,"width":781,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b43fe0c84b194f22b40b89cdbdbe1e37","type":"text","conversion_output":true,"text":"- Change intravenous fluid (IVF) to warmed IVF","text_display":"\n- Change intravenous fluid (IVF) to warmed IVF","confidence":1,"confidence_rate":1},{"cnt":[[494,339],[840,339],[840,380],[494,380]],"region":{"top_left_x":494,"top_left_y":339,"width":347,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a41207e22fc4a56bf8292ee0ccc612d","type":"text","conversion_output":true,"text":"- Warmed blankets","text_display":"\n- Warmed blankets","confidence":1,"confidence_rate":1},{"cnt":[[494,378],[1412,378],[1412,423],[494,423]],"region":{"top_left_x":494,"top_left_y":378,"width":918,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f7580dba68b48489d8d690ed23e2d83","type":"text","conversion_output":true,"text":"- Hourly temperature for the first 4 hours postoperatively","text_display":"\n- Hourly temperature for the first 4 hours postoperatively","confidence":1,"confidence_rate":1},{"cnt":[[494,417],[1506,417],[1506,462],[494,462]],"region":{"top_left_x":494,"top_left_y":416,"width":1013,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a789c5da570745ac97c6d8bb9a182d2a","type":"text","conversion_output":true,"text":"- Record temperature prior to administration of reversal agents","text_display":"\n- Record temperature prior to administration of reversal agents","confidence":1,"confidence_rate":1},{"cnt":[[370,460],[924,460],[924,505],[370,505]],"region":{"top_left_x":369,"top_left_y":459,"width":555,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92d0a0a3d95a4fa388dfb5113339012c","type":"text","conversion_output":true,"text":"- If Temperature \\(\\leq 36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\)","text_display":"\n- If Temperature \\(\\leq 36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\)","confidence":0.9083354473114014,"confidence_rate":0.9982211852059976},{"cnt":[[494,507],[935,507],[935,552],[494,552]],"region":{"top_left_x":494,"top_left_y":507,"width":441,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4df255e6e054266a9fb7d8c4f638627","type":"text","conversion_output":true,"text":"- Bair Hugger set at \\(42^{\\circ} C\\)","text_display":"\n- Bair Hugger set at \\(42^{\\circ} C\\)","confidence":1,"confidence_rate":1},{"cnt":[[494,546],[1523,546],[1523,591],[494,591]],"region":{"top_left_x":494,"top_left_y":545,"width":1030,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05efa2de88bf44fd9108c8e3606ae41c","type":"text","conversion_output":true,"text":"- May remove when temp \\(>36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\) for at least one hour","text_display":"\n- May remove when temp \\(>36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\) for at least one hour","confidence":0.98583984375,"confidence_rate":0.9998341838903301},{"cnt":[[494,589],[1373,589],[1373,629],[494,629]],"region":{"top_left_x":494,"top_left_y":588,"width":879,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d3748ae9133409db8e60202aff74ae0","type":"text","conversion_output":true,"text":"- Suggest defer bath until \\(>36^{\\circ} C\\) for at least one hour","text_display":"\n- Suggest defer bath until \\(>36^{\\circ} C\\) for at least one hour","confidence":1,"confidence_rate":1},{"cnt":[[370,627],[870,627],[870,668],[370,668]],"region":{"top_left_x":369,"top_left_y":627,"width":502,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bd6a1447aa74581adced66584825703","type":"text","conversion_output":true,"text":"- Nasal Thermometer Probes","text_display":"\n- Nasal Thermometer Probes","confidence":1,"confidence_rate":1},{"cnt":[[494,675],[1414,675],[1414,720],[494,720]],"region":{"top_left_x":494,"top_left_y":674,"width":920,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eafe9cf040be4a83b82d48900213ee77","type":"text","conversion_output":true,"text":"- May be used if still in place from Operating Room (OR)","text_display":"\n- May be used if still in place from Operating Room (OR)","confidence":1,"confidence_rate":1},{"cnt":[[494,713],[1882,713],[1882,758],[494,758]],"region":{"top_left_x":494,"top_left_y":713,"width":1389,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9638a18f09e24c0093175a79814bbf95","type":"text","conversion_output":true,"text":"- Should be removed when reversal agents are administered or at 8 hours, whichever","text_display":"\n- Should be removed when reversal agents are administered or at 8 hours, whichever","confidence":1,"confidence_rate":1},{"cnt":[[556,756],[741,756],[741,795],[556,795]],"region":{"top_left_x":556,"top_left_y":756,"width":186,"height":39},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5eb86674dd7a4812831225636d477a39","type":"text","conversion_output":true,"text":"comes first","text_display":" comes first","confidence":1,"confidence_rate":1},{"cnt":[[494,795],[1480,795],[1480,840],[494,840]],"region":{"top_left_x":494,"top_left_y":794,"width":987,"height":47},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c26984df965d44c8b84aab22b85fb644","type":"text","conversion_output":true,"text":"- If accuracy is being questioned, switch to oral temperatures","text_display":"\n- If accuracy is being questioned, switch to oral temperatures","confidence":1,"confidence_rate":1},{"cnt":[[266,907],[672,907],[672,967],[266,967]],"region":{"top_left_x":266,"top_left_y":906,"width":407,"height":61},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bccc768a0a2e46a4bbf9a04cf517d35c","type":"section_header","conversion_output":false,"children_ids":["e92bdd9d306d495c8e30f678c5b2fdc5"],"text":"","text_display":""},{"cnt":[[273,915],[666,915],[666,960],[273,960]],"region":{"top_left_x":272,"top_left_y":915,"width":395,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e92bdd9d306d495c8e30f678c5b2fdc5","type":"text","conversion_output":true,"parent_id":"bccc768a0a2e46a4bbf9a04cf517d35c","text":"IV. Weaning Criteria","text_display":"\n\n\\section*{IV. Weaning Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[402,993],[1626,993],[1626,1566],[402,1566]],"region":{"top_left_x":401,"top_left_y":992,"width":1226,"height":575},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d313d954d734f068132fc01c229e5e5","type":"table","conversion_output":true,"children_ids":["5928c289dd64471499e8b828d1df1cd9","8bdf3fb82be546a78d97ab5041246065","c9e2702d67e247b8bbd9ff645278a8a1","8343872f7b7547d39f0887261bfbee57","56f2e71fae2049faba7ab04a8c2d239c","e3582bd111574bcf88158fb313df86f5","89cd61e463c8430db4c9043d115da395","58bf30a8089140b8b4ae60ae9cc93bd8","c6f852125af446d59d6d8a13e38900db","ec7664000fdf4d069ead4d144701da90","58220b602a8349c69058eea1fd18c1d7","fca859deb17d4f7c9856ae6e7d3fc8c4","66f176b1ec4f4178977884321b12ff7c","1fd3ee5e246041199f4bde6ce1804b2d","b7930abe668d49259aef2999986540ab","341715ad90484b41a423d69452ef56d4","d9137dfcc9a446b188a3b537dc404a57","e57d5db33843403686c99d5d94e90e4d","5eb4bab1271a41b08a1b5e3afb6e75ee","87c3bc202aaf49dabc0274375a11548b","86c052ac14844612a1dbc65f5e003c7a","727377bf920749099612d07eecbc9223","1f13520f4d734c11a0a87e964f206e82","c0bac6f313484365a22bf01b74839492","ba37cfaaeaab4bc083595ebad7c0e5ed","6fb60c8c2547472782e17212c63d0bfe","87adfa766e2849e38d6a1512e7dd9c5a","983911059d974041ac1af7893ea99e61","9f6a06415f4b40049d6aff78a333504d","10da89ae784f4aeeb69bc24f5f9a1a53","02ef0390c92f43d6a192621e6cd6df3b"],"text":"\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|l|}{Patient Criteria for Ventilator Weaning} \\\\\n\\hline Parameter & Criteria \\\\\n\\hline Richmond Agitation-Sedation Scale (RASS) & +1 thru -1 \\\\\n\\hline Cardiac Index & \\(\\geq 2.0 L / min / m ^{2}\\) \\\\\n\\hline Mean Arterial Pressure (MAP) & \\(>60 mm Hg <80 mm Hg\\) \\\\\n\\hline Cardiac Rhythm & Stable \\\\\n\\hline Inotropic Support & No more than one inotropic drip \\\\\n\\hline Chest Tube Drainage & \\(<100 ml /\\) hour \\\\\n\\hline Core Temperature & \\(\\geq 35^{\\circ} C\\) \\\\\n\\hline pH & \\(\\geq 7.32\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|l|}{Patient Criteria for Ventilator Weaning} \\\\\n\\hline Parameter & Criteria \\\\\n\\hline Richmond Agitation-Sedation Scale (RASS) & +1 thru -1 \\\\\n\\hline Cardiac Index & \\(\\geq 2.0 L / min / m ^{2}\\) \\\\\n\\hline Mean Arterial Pressure (MAP) & \\(>60 mm Hg <80 mm Hg\\) \\\\\n\\hline Cardiac Rhythm & Stable \\\\\n\\hline Inotropic Support & No more than one inotropic drip \\\\\n\\hline Chest Tube Drainage & \\(<100 ml /\\) hour \\\\\n\\hline Core Temperature & \\(\\geq 35^{\\circ} C\\) \\\\\n\\hline pH & \\(\\geq 7.32\\) \\\\\n\\hline\n\\end{tabular}","confidence":0.9951212396845222,"confidence_rate":0.9999856998089232},{"cnt":[[420,992],[979,992],[979,1568],[420,1568]],"region":{"top_left_x":420,"top_left_y":992,"width":560,"height":577},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5928c289dd64471499e8b828d1df1cd9","type":"table_column","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[999,992],[1501,992],[1501,1566],[999,1566]],"region":{"top_left_x":998,"top_left_y":992,"width":504,"height":574},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bdf3fb82be546a78d97ab5041246065","type":"table_column","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1016],[1620,1016],[1620,1068],[401,1068]],"region":{"top_left_x":401,"top_left_y":1015,"width":1220,"height":53},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9e2702d67e247b8bbd9ff645278a8a1","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1083],[1622,1083],[1622,1126],[401,1126]],"region":{"top_left_x":401,"top_left_y":1082,"width":1222,"height":45},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8343872f7b7547d39f0887261bfbee57","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1126],[1625,1126],[1625,1215],[401,1215]],"region":{"top_left_x":401,"top_left_y":1126,"width":1224,"height":90},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56f2e71fae2049faba7ab04a8c2d239c","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1217],[1622,1217],[1622,1263],[401,1263]],"region":{"top_left_x":401,"top_left_y":1217,"width":1222,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3582bd111574bcf88158fb313df86f5","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1265],[1622,1265],[1622,1315],[401,1315]],"region":{"top_left_x":401,"top_left_y":1264,"width":1222,"height":51},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89cd61e463c8430db4c9043d115da395","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1315],[1622,1315],[1622,1362],[401,1362]],"region":{"top_left_x":401,"top_left_y":1314,"width":1222,"height":49},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58bf30a8089140b8b4ae60ae9cc93bd8","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1362],[1620,1362],[1620,1412],[401,1412]],"region":{"top_left_x":401,"top_left_y":1362,"width":1220,"height":51},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6f852125af446d59d6d8a13e38900db","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1410],[1622,1410],[1622,1458],[401,1458]],"region":{"top_left_x":401,"top_left_y":1409,"width":1222,"height":49},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec7664000fdf4d069ead4d144701da90","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1462],[1622,1462],[1622,1510],[401,1510]],"region":{"top_left_x":401,"top_left_y":1461,"width":1222,"height":49},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58220b602a8349c69058eea1fd18c1d7","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[401,1514],[1620,1514],[1620,1559],[401,1559]],"region":{"top_left_x":401,"top_left_y":1513,"width":1220,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fca859deb17d4f7c9856ae6e7d3fc8c4","type":"table_row","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"","text_display":""},{"cnt":[[423,1018],[1499,1018],[1499,1068],[423,1068]],"region":{"top_left_x":422,"top_left_y":1017,"width":1077,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66f176b1ec4f4178977884321b12ff7c","type":"table_spanning_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","children_ids":["6d120ac5eb3740719350c975eba94e2a"],"text":"","text_display":"Patient Criteria for Ventilator Weaning","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2},{"cnt":[[427,1022],[1057,1022],[1057,1063],[427,1063]],"region":{"top_left_x":426,"top_left_y":1022,"width":632,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d120ac5eb3740719350c975eba94e2a","type":"simple_cell","conversion_output":false,"parent_id":"66f176b1ec4f4178977884321b12ff7c","text":"Patient Criteria for Ventilator Weaning","text_display":"Patient Criteria for Ventilator Weaning","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2,"confidence":1,"confidence_rate":1},{"cnt":[[427,1087],[605,1087],[605,1122],[427,1122]],"region":{"top_left_x":426,"top_left_y":1087,"width":179,"height":35},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fd3ee5e246041199f4bde6ce1804b2d","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Parameter","text_display":"Parameter","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1087],[1131,1087],[1131,1122],[1003,1122]],"region":{"top_left_x":1003,"top_left_y":1087,"width":128,"height":35},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7930abe668d49259aef2999986540ab","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Criteria","text_display":"Criteria","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[425,1126],[975,1126],[975,1213],[425,1213]],"region":{"top_left_x":424,"top_left_y":1126,"width":551,"height":87},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"341715ad90484b41a423d69452ef56d4","type":"complex_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","children_ids":["acad61a1f8a043f492f26f0c79e7868a","f01f8feabdb943e7ac82dddd4c532611"],"text":"Richmond Agitation-Sedation Scale (RASS)","text_display":"Richmond Agitation-Sedation Scale (RASS)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1131],[975,1131],[975,1172],[427,1172]],"region":{"top_left_x":426,"top_left_y":1130,"width":549,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acad61a1f8a043f492f26f0c79e7868a","type":"text","conversion_output":false,"parent_id":"341715ad90484b41a423d69452ef56d4","text":"Richmond Agitation-Sedation","text_display":"Richmond Agitation-Sedation","confidence":1,"confidence_rate":1},{"cnt":[[427,1170],[646,1170],[646,1211],[427,1211]],"region":{"top_left_x":426,"top_left_y":1169,"width":220,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f01f8feabdb943e7ac82dddd4c532611","type":"text","conversion_output":false,"parent_id":"341715ad90484b41a423d69452ef56d4","text":"Scale (RASS)","text_display":" Scale (RASS)","confidence":1,"confidence_rate":1},{"cnt":[[1003,1170],[1157,1170],[1157,1206],[1003,1206]],"region":{"top_left_x":1003,"top_left_y":1169,"width":154,"height":38},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9137dfcc9a446b188a3b537dc404a57","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"+1 thru -1","text_display":"+1 thru -1","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1222],[648,1222],[648,1258],[427,1258]],"region":{"top_left_x":426,"top_left_y":1221,"width":222,"height":38},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e57d5db33843403686c99d5d94e90e4d","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Cardiac Index","text_display":"Cardiac Index","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1222],[1235,1222],[1235,1258],[1003,1258]],"region":{"top_left_x":1003,"top_left_y":1221,"width":232,"height":38},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5eb4bab1271a41b08a1b5e3afb6e75ee","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"\\(\\geq 2.0 L / min / m ^{2}\\)","text_display":"\\(\\geq 2.0 L / min / m ^{2}\\)","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1269],[897,1269],[897,1312],[427,1312]],"region":{"top_left_x":426,"top_left_y":1269,"width":471,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87c3bc202aaf49dabc0274375a11548b","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Mean Arterial Pressure (MAP)","text_display":"Mean Arterial Pressure (MAP)","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1269],[1382,1267],[1382,1312],[1003,1315]],"region":{"top_left_x":1002,"top_left_y":1267,"width":381,"height":48},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86c052ac14844612a1dbc65f5e003c7a","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"\\(>60 mm Hg <80 mm Hg\\)","text_display":"\\(>60 mm Hg <80 mm Hg\\)","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1317],[680,1317],[680,1362],[427,1362]],"region":{"top_left_x":426,"top_left_y":1316,"width":255,"height":47},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"727377bf920749099612d07eecbc9223","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Cardiac Rhythm","text_display":"Cardiac Rhythm","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1317],[1109,1317],[1109,1358],[1003,1358]],"region":{"top_left_x":1003,"top_left_y":1316,"width":107,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f13520f4d734c11a0a87e964f206e82","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Stable","text_display":"Stable","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1367],[700,1367],[700,1410],[427,1410]],"region":{"top_left_x":426,"top_left_y":1366,"width":274,"height":44},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0bac6f313484365a22bf01b74839492","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Inotropic Support","text_display":"Inotropic Support","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1364],[1497,1364],[1497,1410],[1003,1410]],"region":{"top_left_x":1003,"top_left_y":1364,"width":494,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba37cfaaeaab4bc083595ebad7c0e5ed","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"No more than one inotropic drip","text_display":"No more than one inotropic drip","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1412],[763,1412],[763,1455],[427,1455]],"region":{"top_left_x":426,"top_left_y":1412,"width":337,"height":44},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fb60c8c2547472782e17212c63d0bfe","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Chest Tube Drainage","text_display":"Chest Tube Drainage","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1412],[1226,1412],[1226,1453],[1003,1453]],"region":{"top_left_x":1003,"top_left_y":1412,"width":224,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87adfa766e2849e38d6a1512e7dd9c5a","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"\\(<100 ml /\\) hour","text_display":"\\(<100 ml /\\) hour","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9951212396845222,"confidence_rate":0.999742627846036},{"cnt":[[427,1466],[717,1466],[717,1510],[427,1510]],"region":{"top_left_x":426,"top_left_y":1466,"width":292,"height":44},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"983911059d974041ac1af7893ea99e61","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"Core Temperature","text_display":"Core Temperature","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1464],[1131,1464],[1131,1505],[1003,1505]],"region":{"top_left_x":1003,"top_left_y":1464,"width":128,"height":42},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f6a06415f4b40049d6aff78a333504d","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"\\(\\geq 35^{\\circ} C\\)","text_display":"\\(\\geq 35^{\\circ} C\\)","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[427,1516],[479,1516],[479,1559],[427,1559]],"region":{"top_left_x":426,"top_left_y":1516,"width":53,"height":44},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10da89ae784f4aeeb69bc24f5f9a1a53","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"pH","text_display":"pH","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1003,1516],[1109,1516],[1109,1555],[1003,1555]],"region":{"top_left_x":1003,"top_left_y":1516,"width":107,"height":40},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02ef0390c92f43d6a192621e6cd6df3b","type":"simple_cell","conversion_output":false,"parent_id":"4d313d954d734f068132fc01c229e5e5","text":"\\(\\geq 7.32\\)","text_display":"\\(\\geq 7.32\\)","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[279,1637],[1835,1637],[1835,1687],[279,1687]],"region":{"top_left_x":279,"top_left_y":1637,"width":1556,"height":50},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"774f1ce960b945e399a8d356ce57ec39","type":"text","conversion_output":true,"text":"V. Page ICU Provider at time patient placed on Continuous Positive Airway Pressure (CPAP) 5/5","text_display":"\nV. Page ICU Provider at time patient placed on Continuous Positive Airway Pressure (CPAP) 5/5","confidence":0.67919921875,"confidence_rate":0.9960604255217771},{"cnt":[[494,1680],[1184,1680],[1184,1725],[494,1725]],"region":{"top_left_x":494,"top_left_y":1680,"width":690,"height":46},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9326ef781c2442aca64fe5177eed3892","type":"text","conversion_output":true,"text":"- Notify provider if cuff leak present or not","text_display":"\n- Notify provider if cuff leak present or not","confidence":1,"confidence_rate":1},{"cnt":[[271,1764],[1605,1764],[1605,1811],[271,1811]],"region":{"top_left_x":270,"top_left_y":1763,"width":1335,"height":49},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31342ac6d373476684d0a04b9f985abb","type":"text","conversion_output":true,"text":"VI. Arterial Blood Gas (ABG) should be obtained 30 minutes after placed on CPAP","text_display":"\nVI. Arterial Blood Gas (ABG) should be obtained 30 minutes after placed on CPAP","confidence":1,"confidence_rate":1},{"cnt":[[494,1809],[1629,1809],[1629,1854],[494,1854]],"region":{"top_left_x":494,"top_left_y":1808,"width":1135,"height":47},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf1e49ce8a68467a9a93b747193ccfb5","type":"text","conversion_output":true,"text":"- Patient condition may warrant earlier sampling to expedite extubation","text_display":"\n- Patient condition may warrant earlier sampling to expedite extubation","confidence":1,"confidence_rate":1},{"cnt":[[619,1852],[1085,1852],[1085,1893],[619,1893]],"region":{"top_left_x":618,"top_left_y":1851,"width":467,"height":42},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62bebdaaed4243f28a40a933fea6e9cf","type":"text","conversion_output":true,"text":"- Should discuss with team","text_display":"\n- Should discuss with team","confidence":1,"confidence_rate":1},{"cnt":[[1835,2363],[1886,2363],[1886,2402],[1835,2402]],"region":{"top_left_x":1834,"top_left_y":2363,"width":53,"height":39},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2401b354e3eb494caab7494f2f827ead","type":"page_info","conversion_output":false,"text":"19","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-19","page":19,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76c73c85afe14fb5993b21ab1ac97970","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b668e69c52c45d79f02e35cb03b2a22","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1109916ba4184350807d34279b59c500","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,327],[483,327],[483,374],[241,374]],"region":{"top_left_x":240,"top_left_y":326,"width":244,"height":48},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4dbd7f41d4a4c63a5f536ad5ddbabe9","type":"section_header","conversion_output":false,"children_ids":["354701175fdd4011a56821b346f2c0d3"],"text":"","text_display":""},{"cnt":[[245,331],[479,331],[479,370],[245,370]],"region":{"top_left_x":244,"top_left_y":330,"width":236,"height":40},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"354701175fdd4011a56821b346f2c0d3","type":"text","conversion_output":true,"parent_id":"b4dbd7f41d4a4c63a5f536ad5ddbabe9","text":"EXTUBATION","text_display":"\n\n\\section*{EXTUBATION}","confidence":1,"confidence_rate":1},{"cnt":[[258,404],[707,404],[707,458],[258,458]],"region":{"top_left_x":257,"top_left_y":403,"width":450,"height":55},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3dcc62295ab04cd1bcfef996d3f2e31e","type":"section_header","conversion_output":false,"children_ids":["90dff42464a0472682380b2471d74e12"],"text":"","text_display":""},{"cnt":[[262,408],[700,408],[700,449],[262,449]],"region":{"top_left_x":262,"top_left_y":408,"width":439,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90dff42464a0472682380b2471d74e12","type":"text","conversion_output":true,"parent_id":"3dcc62295ab04cd1bcfef996d3f2e31e","text":"VII. Extubation Criteria","text_display":"\n\n\\section*{VII. Extubation Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[374,483],[1751,483],[1751,1190],[374,1190]],"region":{"top_left_x":373,"top_left_y":483,"width":1378,"height":708},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20c91fb1128c4af8bf14d0cbd3a8f77e","type":"table","conversion_output":true,"children_ids":["56d44c438b3e421c97ec42af9575217f","463d523be730434ca876cad49912fefb","9a774302f1ff4ab4b0e7811f61619f66","be8bf24a082f47c49caae11d9c60bf6d","0e02a878ec59471581df86e1509cfc55","a5d16ef403aa483f863812a2ab43c959","540e47b3d8bb450e806e2e4c72ae218f","7d4f3fa3a5c04e9eb1f426ff4259ac68","6dfcf3b76f324265827fa20d488bc898","4d8ac4f00f994885a5109229d1e52351","cffb55003f574ac4ac81d6d5a49b5488","2330ee31bde94cc9ab9c58defeb95eae","bbcf7bb77ba84f3a8e8e1feaaeb9c322","02ca3001537e4b1e9c9e4b087a9e7ea0","8e9bd952bca74086aeba76ce0d0efab6","408752ca68494729bfe799f3b9fdb28c","eaa8bc3030c24e22b5dd42d43c60cfe7","217fb1f1672b4a8d82c01f0285241a95","0f3b0230780a4aadb1085cb9f2bdbe89","272ed9a0ce8246d782c9c0fe506c814d","392b7f5f2d7f4c4ea184214b3c059657","ccfb01579be144388d31c64ad3e6e2bd","a9bf00434c8a4662ba8fb0db6c7fc7d0","b03c58705e3c47a6a66d547ad3a26a8a","fa7c9e7e7ab54abc8050f9e72f0ee779","fbfd2d99497d490196fd0679a42a372e","87facb49705944e6ad179b5eeaf14e4b","e086653926d440efa3fd9643b240d0b0","00135f8541b84f00bb5af57da3d4b710","2dd34b53324d4549a454cf699cc9a131","1efc933092b244c2a676f6a71aceff66","77ec52943d0d434aad956e2a74588182","eca49dc9ed9442eb8c69e5dc7a5e4a7c","b74685bb5651407b98937deb0a771ad2","a4b8c2e5a96e45f0849924667c29ff01","cc0052c771064a73a9dc67d3ba08ff16","e894976dbe604a008a45a932e7f2e6d9","74cbd73647094f0fad7e5a2480d3cc7e","56dbf4c8cb6a46a38a02293cdde14aa3","d1008375b2bb4d61b25edaab5d901385"],"text":"\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|l|}{Patient Criteria for Extubation} \\\\\n\\hline Parameter & Criteria \\\\\n\\hline Strength & Able to lift and hold head for \\(\\geq 5 sec\\) \\\\\n\\hline RASS & +1 to -1 \\\\\n\\hline Heart Rate & 60-100 \\\\\n\\hline Cardiac Index & \\(\\geq 2.0 L / min / m ^{2}\\) \\\\\n\\hline MAP & \\(>60 mm Hg <90 mm Hg\\) \\\\\n\\hline Cardiac Rhythm & Stable \\\\\n\\hline Inotropic Support & No increase \\\\\n\\hline Chest Tube Drainage & \\(<100 ml /\\) hour and not increasing \\\\\n\\hline Core Temperature & \\(\\geq 36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\) \\\\\n\\hline Respiratory Rate & \\(10-24 bpm\\) \\\\\n\\hline ABG on following settings: CPAP FiO2 \\(\\leq 50 \\%\\) PEEP 5 PS 5 & pH 7.34-7.45; pCO2 35-45; \\(PaO 2 \\geq 80\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|l|}{Patient Criteria for Extubation} \\\\\n\\hline Parameter & Criteria \\\\\n\\hline Strength & Able to lift and hold head for \\(\\geq 5 sec\\) \\\\\n\\hline RASS & +1 to -1 \\\\\n\\hline Heart Rate & 60-100 \\\\\n\\hline Cardiac Index & \\(\\geq 2.0 L / min / m ^{2}\\) \\\\\n\\hline MAP & \\(>60 mm Hg <90 mm Hg\\) \\\\\n\\hline Cardiac Rhythm & Stable \\\\\n\\hline Inotropic Support & No increase \\\\\n\\hline Chest Tube Drainage & \\(<100 ml /\\) hour and not increasing \\\\\n\\hline Core Temperature & \\(\\geq 36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\) \\\\\n\\hline Respiratory Rate & \\(10-24 bpm\\) \\\\\n\\hline ABG on following settings: CPAP FiO2 \\(\\leq 50 \\%\\) PEEP 5 PS 5 & pH 7.34-7.45; pCO2 35-45; \\(PaO 2 \\geq 80\\) \\\\\n\\hline\n\\end{tabular}","confidence":0.73046875,"confidence_rate":0.9995255039883358},{"cnt":[[390,483],[921,483],[921,1189],[390,1189]],"region":{"top_left_x":390,"top_left_y":483,"width":531,"height":706},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56d44c438b3e421c97ec42af9575217f","type":"table_column","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[1051,483],[1659,483],[1659,1191],[1051,1191]],"region":{"top_left_x":1050,"top_left_y":483,"width":610,"height":709},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"463d523be730434ca876cad49912fefb","type":"table_column","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,494],[1748,494],[1748,544],[373,544]],"region":{"top_left_x":373,"top_left_y":493,"width":1376,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a774302f1ff4ab4b0e7811f61619f66","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,565],[1750,565],[1750,609],[373,609]],"region":{"top_left_x":373,"top_left_y":565,"width":1378,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be8bf24a082f47c49caae11d9c60bf6d","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,613],[1748,613],[1748,661],[373,661]],"region":{"top_left_x":373,"top_left_y":612,"width":1376,"height":49},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e02a878ec59471581df86e1509cfc55","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,661],[1750,661],[1750,702],[373,702]],"region":{"top_left_x":373,"top_left_y":660,"width":1378,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5d16ef403aa483f863812a2ab43c959","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,708],[1750,708],[1750,749],[373,749]],"region":{"top_left_x":373,"top_left_y":708,"width":1378,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"540e47b3d8bb450e806e2e4c72ae218f","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,756],[1750,756],[1750,801],[373,801]],"region":{"top_left_x":373,"top_left_y":755,"width":1378,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d4f3fa3a5c04e9eb1f426ff4259ac68","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,803],[1748,803],[1748,849],[373,849]],"region":{"top_left_x":373,"top_left_y":803,"width":1376,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dfcf3b76f324265827fa20d488bc898","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,851],[1750,851],[1750,897],[373,897]],"region":{"top_left_x":373,"top_left_y":851,"width":1378,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d8ac4f00f994885a5109229d1e52351","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,899],[1750,899],[1750,946],[373,946]],"region":{"top_left_x":373,"top_left_y":898,"width":1378,"height":49},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cffb55003f574ac4ac81d6d5a49b5488","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,946],[1750,946],[1750,992],[373,992]],"region":{"top_left_x":373,"top_left_y":946,"width":1378,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2330ee31bde94cc9ab9c58defeb95eae","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,994],[1750,994],[1750,1042],[373,1042]],"region":{"top_left_x":373,"top_left_y":994,"width":1378,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbcf7bb77ba84f3a8e8e1feaaeb9c322","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,1042],[1748,1042],[1748,1087],[373,1087]],"region":{"top_left_x":373,"top_left_y":1041,"width":1376,"height":47},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02ca3001537e4b1e9c9e4b087a9e7ea0","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[373,1089],[1752,1089],[1752,1182],[373,1182]],"region":{"top_left_x":373,"top_left_y":1089,"width":1380,"height":94},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e9bd952bca74086aeba76ce0d0efab6","type":"table_row","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"","text_display":""},{"cnt":[[395,496],[1661,496],[1661,544],[395,544]],"region":{"top_left_x":394,"top_left_y":495,"width":1268,"height":49},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"408752ca68494729bfe799f3b9fdb28c","type":"table_spanning_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","children_ids":["09006fbaefe946bfb396d7572fef9814"],"text":"","text_display":"Patient Criteria for Extubation","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2},{"cnt":[[399,500],[895,500],[895,537],[399,537]],"region":{"top_left_x":398,"top_left_y":500,"width":497,"height":38},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09006fbaefe946bfb396d7572fef9814","type":"simple_cell","conversion_output":false,"parent_id":"408752ca68494729bfe799f3b9fdb28c","text":"Patient Criteria for Extubation","text_display":"Patient Criteria for Extubation","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2,"confidence":1,"confidence_rate":1},{"cnt":[[399,570],[574,570],[574,602],[399,602]],"region":{"top_left_x":398,"top_left_y":569,"width":177,"height":34},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaa8bc3030c24e22b5dd42d43c60cfe7","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Parameter","text_display":"Parameter","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1057,570],[1181,570],[1181,602],[1057,602]],"region":{"top_left_x":1057,"top_left_y":569,"width":124,"height":34},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"217fb1f1672b4a8d82c01f0285241a95","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Criteria","text_display":"Criteria","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,617],[535,617],[535,658],[399,658]],"region":{"top_left_x":398,"top_left_y":617,"width":138,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f3b0230780a4aadb1085cb9f2bdbe89","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Strength","text_display":"Strength","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.998046875,"confidence_rate":0.9998496240125406},{"cnt":[[1053,617],[1614,617],[1614,652],[1053,652]],"region":{"top_left_x":1052,"top_left_y":617,"width":562,"height":35},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"272ed9a0ce8246d782c9c0fe506c814d","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Able to lift and hold head for \\(\\geq 5 sec\\)","text_display":"Able to lift and hold head for \\(\\geq 5 sec\\)","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.73046875,"confidence_rate":0.9927226826228756},{"cnt":[[399,665],[496,665],[496,697],[399,697]],"region":{"top_left_x":398,"top_left_y":664,"width":99,"height":34},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"392b7f5f2d7f4c4ea184214b3c059657","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"RASS","text_display":"RASS","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1053,665],[1176,665],[1176,697],[1053,697]],"region":{"top_left_x":1052,"top_left_y":664,"width":125,"height":34},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccfb01579be144388d31c64ad3e6e2bd","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"+1 to -1","text_display":"+1 to -1","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,713],[570,713],[570,745],[399,745]],"region":{"top_left_x":398,"top_left_y":712,"width":173,"height":34},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9bf00434c8a4662ba8fb0db6c7fc7d0","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Heart Rate","text_display":"Heart Rate","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1055,713],[1168,713],[1168,745],[1055,745]],"region":{"top_left_x":1055,"top_left_y":712,"width":113,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b03c58705e3c47a6a66d547ad3a26a8a","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"60-100","text_display":"60-100","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,760],[618,760],[618,793],[399,793]],"region":{"top_left_x":398,"top_left_y":760,"width":220,"height":33},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa7c9e7e7ab54abc8050f9e72f0ee779","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Cardiac Index","text_display":"Cardiac Index","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1053,756],[1285,756],[1285,793],[1053,793]],"region":{"top_left_x":1052,"top_left_y":755,"width":233,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbfd2d99497d490196fd0679a42a372e","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"\\(\\geq 2.0 L / min / m ^{2}\\)","text_display":"\\(\\geq 2.0 L / min / m ^{2}\\)","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,808],[481,808],[481,842],[399,842]],"region":{"top_left_x":398,"top_left_y":807,"width":84,"height":36},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87facb49705944e6ad179b5eeaf14e4b","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"MAP","text_display":"MAP","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1053,808],[1432,808],[1432,849],[1053,849]],"region":{"top_left_x":1052,"top_left_y":807,"width":380,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e086653926d440efa3fd9643b240d0b0","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"\\(>60 mm Hg <90 mm Hg\\)","text_display":"\\(>60 mm Hg <90 mm Hg\\)","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9985356330871582,"confidence_rate":0.9999333913027334},{"cnt":[[399,855],[652,855],[652,894],[399,894]],"region":{"top_left_x":398,"top_left_y":855,"width":255,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00135f8541b84f00bb5af57da3d4b710","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Cardiac Rhythm","text_display":"Cardiac Rhythm","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1057,855],[1159,855],[1159,888],[1057,888]],"region":{"top_left_x":1057,"top_left_y":855,"width":103,"height":33},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2dd34b53324d4549a454cf699cc9a131","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Stable","text_display":"Stable","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,903],[670,903],[670,944],[399,944]],"region":{"top_left_x":398,"top_left_y":903,"width":272,"height":42},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1efc933092b244c2a676f6a71aceff66","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Inotropic Support","text_display":"Inotropic Support","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1057,903],[1246,903],[1246,936],[1057,936]],"region":{"top_left_x":1057,"top_left_y":903,"width":189,"height":33},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77ec52943d0d434aad956e2a74588182","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"No increase","text_display":"No increase","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,951],[732,951],[732,992],[399,992]],"region":{"top_left_x":398,"top_left_y":950,"width":335,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eca49dc9ed9442eb8c69e5dc7a5e4a7c","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Chest Tube Drainage","text_display":"Chest Tube Drainage","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1055,951],[1566,951],[1566,990],[1055,990]],"region":{"top_left_x":1055,"top_left_y":950,"width":512,"height":40},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b74685bb5651407b98937deb0a771ad2","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"\\(<100 ml /\\) hour and not increasing","text_display":"\\(<100 ml /\\) hour and not increasing","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9965834617614746,"confidence_rate":0.9999099412151965},{"cnt":[[399,998],[687,998],[687,1040],[399,1040]],"region":{"top_left_x":398,"top_left_y":998,"width":289,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4b8c2e5a96e45f0849924667c29ff01","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Core Temperature","text_display":"Core Temperature","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1053,998],[1306,998],[1306,1040],[1053,1040]],"region":{"top_left_x":1052,"top_left_y":998,"width":255,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc0052c771064a73a9dc67d3ba08ff16","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"\\(\\geq 36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\)","text_display":"\\(\\geq 36^{\\circ} C \\left(96.8^{\\circ} F \\right)\\)","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[399,1046],[665,1046],[665,1087],[399,1087]],"region":{"top_left_x":398,"top_left_y":1046,"width":268,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e894976dbe604a008a45a932e7f2e6d9","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"Respiratory Rate","text_display":"Respiratory Rate","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1057,1046],[1224,1046],[1224,1087],[1057,1087]],"region":{"top_left_x":1057,"top_left_y":1046,"width":168,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74cbd73647094f0fad7e5a2480d3cc7e","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"\\(10-24 bpm\\)","text_display":"\\(10-24 bpm\\)","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[395,1089],[921,1089],[921,1178],[395,1178]],"region":{"top_left_x":394,"top_left_y":1089,"width":527,"height":90},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56dbf4c8cb6a46a38a02293cdde14aa3","type":"complex_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","children_ids":["c6178ae506da477ab15e8a3021b71e05","7780cd4036be4139a707aa9d5e2ecbd3"],"text":"ABG on following settings: CPAP FiO2 \\(\\leq 50 \\%\\) PEEP 5 PS 5","text_display":"ABG on following settings: CPAP FiO2 \\(\\leq 50 \\%\\) PEEP 5 PS 5","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.8177506923675537,"confidence_rate":0.9972094873237549},{"cnt":[[399,1094],[808,1094],[808,1135],[399,1135]],"region":{"top_left_x":398,"top_left_y":1093,"width":411,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6178ae506da477ab15e8a3021b71e05","type":"text","conversion_output":false,"parent_id":"56dbf4c8cb6a46a38a02293cdde14aa3","text":"ABG on following settings:","text_display":"ABG on following settings:","confidence":1,"confidence_rate":1},{"cnt":[[399,1137],[917,1137],[917,1174],[399,1174]],"region":{"top_left_x":398,"top_left_y":1136,"width":519,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7780cd4036be4139a707aa9d5e2ecbd3","type":"text","conversion_output":false,"parent_id":"56dbf4c8cb6a46a38a02293cdde14aa3","text":"CPAP FiO2 \\(\\leq 50 \\%\\) PEEP 5 PS 5","text_display":" CPAP FiO2 \\(\\leq 50 \\%\\) PEEP 5 PS 5","confidence":0.8177506923675537,"confidence_rate":0.9944267616085062},{"cnt":[[1055,1115],[1653,1115],[1653,1156],[1055,1156]],"region":{"top_left_x":1055,"top_left_y":1115,"width":598,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1008375b2bb4d61b25edaab5d901385","type":"simple_cell","conversion_output":false,"parent_id":"20c91fb1128c4af8bf14d0cbd3a8f77e","text":"pH 7.34-7.45; pCO2 35-45; \\(PaO 2 \\geq 80\\)","text_display":"pH 7.34-7.45; pCO2 35-45; \\(PaO 2 \\geq 80\\)","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9613581563865505,"confidence_rate":0.9990152789539201},{"cnt":[[254,1263],[1880,1263],[1880,1308],[254,1308]],"region":{"top_left_x":253,"top_left_y":1263,"width":1627,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"922cb34667c24b55a66cf1d2cbf6c2bb","type":"text","conversion_output":true,"text":"VIII. If not within fast track criteria then page the ICU provider immediately to discuss plan of action and","text_display":"\nVIII. If not within fast track criteria then page the ICU provider immediately to discuss plan of action and","confidence":1,"confidence_rate":1},{"cnt":[[378,1302],[1046,1302],[1046,1347],[378,1347]],"region":{"top_left_x":378,"top_left_y":1301,"width":669,"height":47},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5f6a9ef2561462a8c8e82a1006e1e65","type":"text","conversion_output":true,"text":"if not ready for extubation return to step IV.","text_display":" if not ready for extubation return to step IV.","confidence":1,"confidence_rate":1},{"cnt":[[271,1384],[814,1384],[814,1437],[271,1437]],"region":{"top_left_x":270,"top_left_y":1383,"width":545,"height":55},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d593e3a53de341c89b6e7083eb3a9750","type":"section_header","conversion_output":false,"children_ids":["47f82a94fae644a490b93cd2b1226d0b"],"text":"","text_display":""},{"cnt":[[275,1388],[810,1388],[810,1433],[275,1433]],"region":{"top_left_x":275,"top_left_y":1387,"width":535,"height":47},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47f82a94fae644a490b93cd2b1226d0b","type":"text","conversion_output":true,"parent_id":"d593e3a53de341c89b6e7083eb3a9750","text":"IX. Meets Extubation Criteria","text_display":"\n\n\\section*{IX. Meets Extubation Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[494,1431],[1880,1431],[1880,1476],[494,1476]],"region":{"top_left_x":494,"top_left_y":1430,"width":1386,"height":46},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3f81bd32c7542bda5e0d6bf60773cb2","type":"text","conversion_output":true,"text":"- Decision to proceed with extubation may be made by the CVICU RN, in coordination","text_display":"\n- Decision to proceed with extubation may be made by the CVICU RN, in coordination","confidence":0.9921875,"confidence_rate":0.9999098525984519},{"cnt":[[554,1474],[862,1474],[862,1515],[554,1515]],"region":{"top_left_x":554,"top_left_y":1473,"width":308,"height":42},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70148625fde9451f98e8be304961547e","type":"text","conversion_output":true,"text":"with the CVICU RT","text_display":" with the CVICU RT","confidence":1,"confidence_rate":1},{"cnt":[[494,1515],[1880,1515],[1880,1560],[494,1560]],"region":{"top_left_x":494,"top_left_y":1514,"width":1386,"height":46},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8bd6f4b434b449bbe42d28deca3640e","type":"text","conversion_output":true,"text":"- For patients with a difficult airway, the plan to extubate should be discussed with the","text_display":"\n- For patients with a difficult airway, the plan to extubate should be discussed with the","confidence":1,"confidence_rate":1},{"cnt":[[559,1555],[1291,1555],[1291,1601],[559,1601]],"region":{"top_left_x":558,"top_left_y":1555,"width":734,"height":46},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0754c30614e347ca8eaaf4db0376dcc7","type":"text","conversion_output":true,"text":"intensivist and ICU provider, prior to extubation","text_display":" intensivist and ICU provider, prior to extubation","confidence":0.99951171875,"confidence_rate":0.9999909555872323},{"cnt":[[279,1635],[544,1635],[544,1687],[279,1687]],"region":{"top_left_x":279,"top_left_y":1634,"width":265,"height":53},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbd2f41ad8f544aca7578cbd47cd267f","type":"section_header","conversion_output":false,"children_ids":["74277f6730764a999dcf8489ff166d6a"],"text":"","text_display":""},{"cnt":[[284,1641],[537,1641],[537,1682],[284,1682]],"region":{"top_left_x":283,"top_left_y":1641,"width":255,"height":42},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74277f6730764a999dcf8489ff166d6a","type":"text","conversion_output":true,"parent_id":"cbd2f41ad8f544aca7578cbd47cd267f","text":"X. Extubate","text_display":"\n\n\\section*{X. Extubate}","confidence":1,"confidence_rate":1},{"cnt":[[494,1680],[1708,1680],[1708,1727],[494,1727]],"region":{"top_left_x":494,"top_left_y":1680,"width":1215,"height":48},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"818191b1d1bc4ed58bcb4622c249e2f6","type":"text","conversion_output":true,"text":"- Head of Bed (HOB) should be elevated at least \\(60^{\\circ}\\) unless contraindicated","text_display":"\n- Head of Bed (HOB) should be elevated at least \\(60^{\\circ}\\) unless contraindicated","confidence":0.9980480668600649,"confidence_rate":0.9999780469753078},{"cnt":[[494,1723],[1880,1723],[1880,1768],[494,1768]],"region":{"top_left_x":494,"top_left_y":1723,"width":1386,"height":46},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e97eac99215d4db1a82e23933fd8e96b","type":"text","conversion_output":true,"text":"- Endotracheal Tube (ETT) should be suctioned prior to extubation, with","text_display":"\n- Endotracheal Tube (ETT) should be suctioned prior to extubation, with","confidence":1,"confidence_rate":1},{"cnt":[[556,1766],[1880,1766],[1880,1809],[556,1809]],"region":{"top_left_x":556,"top_left_y":1766,"width":1324,"height":43},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3383895b94894073bc8f0975de37bb58","type":"text","conversion_output":true,"text":"hyperoxygenation of the patient before and after suctioning (use the Suction 100\\%","text_display":" hyperoxygenation of the patient before and after suctioning (use the Suction 100\\%","confidence":0.97900390625,"confidence_rate":0.9997532903631924},{"cnt":[[559,1805],[909,1805],[909,1850],[559,1850]],"region":{"top_left_x":558,"top_left_y":1804,"width":351,"height":46},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b7ca29895864fcc86b48550547cb88e","type":"text","conversion_output":true,"text":"function on ventilator).","text_display":" function on ventilator).","confidence":1,"confidence_rate":1},{"cnt":[[494,1848],[1510,1848],[1510,1893],[494,1893]],"region":{"top_left_x":494,"top_left_y":1847,"width":1017,"height":46},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"273bb99dd04045c18f0027ba8fdfc3f1","type":"text","conversion_output":true,"text":"- Suction mouth with Yankauer immediately prior to extubation.","text_display":"\n- Suction mouth with Yankauer immediately prior to extubation.","confidence":1,"confidence_rate":1},{"cnt":[[494,1891],[1592,1891],[1592,1936],[494,1936]],"region":{"top_left_x":494,"top_left_y":1890,"width":1098,"height":46},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9578fb0eca4d4c818cfb7753f14e4136","type":"text","conversion_output":true,"text":"- Nasogastric tube, if present, should be aspirated and discontinued.","text_display":"\n- Nasogastric tube, if present, should be aspirated and discontinued.","confidence":1,"confidence_rate":1},{"cnt":[[494,1934],[1880,1934],[1880,1979],[494,1979]],"region":{"top_left_x":494,"top_left_y":1933,"width":1386,"height":46},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c369cc89f734d64b91abfbafe0795c8","type":"text","conversion_output":true,"text":"- Explain procedure to patient, informing them that a strong cough will be necessary as","text_display":"\n- Explain procedure to patient, informing them that a strong cough will be necessary as","confidence":1,"confidence_rate":1},{"cnt":[[556,1972],[1742,1972],[1742,2017],[556,2017]],"region":{"top_left_x":556,"top_left_y":1972,"width":1187,"height":46},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24096a816520485887a852cdfa0b0035","type":"text","conversion_output":true,"text":"the ETT is withdrawn; explain that patient may be unable to speak for a time.","text_display":" the ETT is withdrawn; explain that patient may be unable to speak for a time.","confidence":1,"confidence_rate":1},{"cnt":[[494,2013],[1807,2013],[1807,2060],[494,2060]],"region":{"top_left_x":494,"top_left_y":2013,"width":1313,"height":48},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ca3a97c75e74066b271a1dbe7bd9d5e","type":"text","conversion_output":true,"text":"- Patient to be placed on face tent/nasal cannula to provide adequate \\(SpO _{2} \\geq 92 \\%\\)","text_display":"\n- Patient to be placed on face tent/nasal cannula to provide adequate \\(SpO _{2} \\geq 92 \\%\\)","confidence":1,"confidence_rate":1},{"cnt":[[1830,2363],[1882,2363],[1882,2402],[1830,2402]],"region":{"top_left_x":1830,"top_left_y":2363,"width":53,"height":39},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ce47dbe267b4b6d88037d6001aa42fa","type":"page_info","conversion_output":false,"text":"20","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-20","page":20,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d58498ba2b7343f1ba7da076ea91195a","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13136c0789524393b78f015d484fd829","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"983b9af3ac5e4dfd9b4b3c85ab5c60cd","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,327],[698,327],[698,374],[241,374]],"region":{"top_left_x":240,"top_left_y":326,"width":459,"height":48},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce44a4dadab1456098a94fbc38f0f903","type":"section_header","conversion_output":false,"children_ids":["42cfcda5e3344ac792664949c2daf5d8"],"text":"","text_display":""},{"cnt":[[245,331],[694,331],[694,372],[245,372]],"region":{"top_left_x":244,"top_left_y":330,"width":450,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42cfcda5e3344ac792664949c2daf5d8","type":"text","conversion_output":true,"parent_id":"ce44a4dadab1456098a94fbc38f0f903","text":"POST-EXTUBATION CARE","text_display":"\n\n\\section*{POST-EXTUBATION CARE}","confidence":1,"confidence_rate":1},{"cnt":[[245,408],[1880,408],[1880,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":1636,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f9446b04b94401cbe257d4c18fd8029","type":"text","conversion_output":true,"text":"Over the next several hours, oxygen should be weaned to maintain peripheral capillary oxygen saturation","text_display":"\n\nOver the next several hours, oxygen should be weaned to maintain peripheral capillary oxygen saturation","confidence":1,"confidence_rate":1},{"cnt":[[245,455],[475,455],[475,501],[245,501]],"region":{"top_left_x":244,"top_left_y":455,"width":231,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0273ef2a25864fa8868f97229f0f795f","type":"text","conversion_output":true,"text":"\\(\\left( SpO _{2}\\right) \\geq 92 \\%\\).","text_display":" \\(\\left( SpO _{2}\\right) \\geq 92 \\%\\).","confidence":1,"confidence_rate":1},{"cnt":[[632,533],[1491,533],[1491,1025],[632,1025]],"region":{"top_left_x":631,"top_left_y":532,"width":861,"height":493},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"636c79d1c2b8448ba789798788647e7e","type":"table","conversion_output":true,"children_ids":["676c951ef06547b49450281320bcd7fa","c868074b862e437bb19a730837bcac98","f5c5cae03d784f85aa1b31d3ed9d3ed9","cb4705223e1c480b8b475136b3cc5685","4aa3c1c3ca414fbe8615b3c30f94733a","1c52771a0298467ba4bb04c7c33cc987","bb46dbc0d19f48648ef4f9f49f5a58fb","ebec6a7a726b4b61b8d5bb73fc57500d","87fed04f6d354053aee0baf261588048","70df9e8f96e4415680d9818eb8bb3343","18cbbed3e6f04970bc45fc7e68aeaeaf","24137a12e4dc4a2088a4c8ddfedae745","557bfa68950e4f418ea8f64634137d5e","cf491d036b364a5382d74bf485feec57","f64b7d23aeb647ee8156caa031d2165e","cb522e1fbd05494ab163e3cd91d9136e","449134ff2866423280def33002f63cb5","b5e7c70ad58f4f7faadf4a9bb89c35de","67d552e778034cafb8e63f83afb8d2b1","66008f96059a4d6ba913fb9eb31976be","5fb72d300a974d46bba70b76a1858605","f9e31b89810b4438a542708eac94e410","7ff5681332704763b1c58fab68e63939","4175568c0a86473b83a6cac68fa597d3","ce53764c1e054b9897516983d6886726","38f350a4ef934f07911692cbbcf17184","6d5bba49301a44c285c00e64bfddae1c","51877602b32745b29eccabd3899f20c7"],"text":"\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|c|}{Nasal Cannula \\(O _{ 2 }\\) Flow / FiO \\(2 _{ 2 }\\)} \\\\\n\\hline Oxygen Flow L/min & Approximate \\(FiO _{2}\\) \\\\\n\\hline Room Air & 21\\% \\\\\n\\hline \\(1 L / min\\) & 24\\% \\\\\n\\hline \\(2 L / min\\) & 28\\% \\\\\n\\hline \\(3 L / min\\) & 32\\% \\\\\n\\hline \\(4 L / min\\) & 36\\% \\\\\n\\hline \\(5 L / min\\) & 40\\% \\\\\n\\hline \\(6 L / min\\) & 44\\% \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|c|}{Nasal Cannula \\(O _{ 2 }\\) Flow / FiO \\(2 _{ 2 }\\)} \\\\\n\\hline Oxygen Flow L/min & Approximate \\(FiO _{2}\\) \\\\\n\\hline Room Air & 21\\% \\\\\n\\hline \\(1 L / min\\) & 24\\% \\\\\n\\hline \\(2 L / min\\) & 28\\% \\\\\n\\hline \\(3 L / min\\) & 32\\% \\\\\n\\hline \\(4 L / min\\) & 36\\% \\\\\n\\hline \\(5 L / min\\) & 40\\% \\\\\n\\hline \\(6 L / min\\) & 44\\% \\\\\n\\hline\n\\end{tabular}","confidence":0.9218672276117559,"confidence_rate":0.9998203522382486},{"cnt":[[659,532],[993,532],[993,1026],[659,1026]],"region":{"top_left_x":659,"top_left_y":532,"width":334,"height":494},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"676c951ef06547b49450281320bcd7fa","type":"table_column","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[1094,532],[1402,532],[1402,1026],[1094,1026]],"region":{"top_left_x":1094,"top_left_y":532,"width":308,"height":494},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c868074b862e437bb19a730837bcac98","type":"table_column","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,558],[1491,558],[1491,608],[631,608]],"region":{"top_left_x":631,"top_left_y":557,"width":860,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5c5cae03d784f85aa1b31d3ed9d3ed9","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,619],[1491,619],[1491,666],[631,666]],"region":{"top_left_x":631,"top_left_y":618,"width":860,"height":49},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb4705223e1c480b8b475136b3cc5685","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,673],[1491,673],[1491,714],[631,714]],"region":{"top_left_x":631,"top_left_y":672,"width":860,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4aa3c1c3ca414fbe8615b3c30f94733a","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,723],[1491,723],[1491,764],[631,764]],"region":{"top_left_x":631,"top_left_y":722,"width":860,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c52771a0298467ba4bb04c7c33cc987","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,770],[1491,770],[1491,814],[631,814]],"region":{"top_left_x":631,"top_left_y":770,"width":860,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb46dbc0d19f48648ef4f9f49f5a58fb","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,822],[1491,822],[1491,863],[631,863]],"region":{"top_left_x":631,"top_left_y":822,"width":860,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebec6a7a726b4b61b8d5bb73fc57500d","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,870],[1491,870],[1491,911],[631,911]],"region":{"top_left_x":631,"top_left_y":869,"width":860,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87fed04f6d354053aee0baf261588048","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,920],[1491,917],[1491,960],[631,962]],"region":{"top_left_x":630,"top_left_y":917,"width":861,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70df9e8f96e4415680d9818eb8bb3343","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[631,969],[1491,969],[1491,1011],[631,1011]],"region":{"top_left_x":631,"top_left_y":969,"width":860,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18cbbed3e6f04970bc45fc7e68aeaeaf","type":"table_row","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"","text_display":""},{"cnt":[[659,560],[1404,560],[1404,608],[659,608]],"region":{"top_left_x":659,"top_left_y":560,"width":746,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24137a12e4dc4a2088a4c8ddfedae745","type":"table_spanning_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","children_ids":["2e59119f57164d90abc1a2ce6758ce56"],"text":"","text_display":"Nasal Cannula \\(O _{ 2 }\\) Flow / FiO \\(2 _{ 2 }\\)","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2},{"cnt":[[761,562],[1244,562],[1244,603],[761,603]],"region":{"top_left_x":760,"top_left_y":562,"width":484,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e59119f57164d90abc1a2ce6758ce56","type":"simple_cell","conversion_output":false,"parent_id":"24137a12e4dc4a2088a4c8ddfedae745","text":"Nasal Cannula \\(O _{ 2 }\\) Flow / FiO \\(2 _{ 2 }\\)","text_display":"Nasal Cannula \\(O _{ 2 }\\) Flow / FiO \\(2 _{ 2 }\\)","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2,"confidence":0.5210228299079221,"confidence_rate":0.9895395879013283},{"cnt":[[666,623],[988,623],[988,664],[666,664]],"region":{"top_left_x":665,"top_left_y":622,"width":324,"height":43},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"557bfa68950e4f418ea8f64634137d5e","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"Oxygen Flow L/min","text_display":"Oxygen Flow L/min","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1099,623],[1400,623],[1400,664],[1099,664]],"region":{"top_left_x":1098,"top_left_y":622,"width":302,"height":43},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf491d036b364a5382d74bf485feec57","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"Approximate \\(FiO _{2}\\)","text_display":"Approximate \\(FiO _{2}\\)","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9218672276117559,"confidence_rate":0.9972918712627182},{"cnt":[[752,675],[906,675],[906,712],[752,712]],"region":{"top_left_x":752,"top_left_y":674,"width":155,"height":38},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f64b7d23aeb647ee8156caa031d2165e","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"Room Air","text_display":"Room Air","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1211,675],[1289,675],[1289,714],[1211,714]],"region":{"top_left_x":1211,"top_left_y":674,"width":79,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb522e1fbd05494ab163e3cd91d9136e","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"21\\%","text_display":"21\\%","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[765,725],[889,725],[889,759],[765,759]],"region":{"top_left_x":765,"top_left_y":724,"width":124,"height":36},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"449134ff2866423280def33002f63cb5","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"\\(1 L / min\\)","text_display":"\\(1 L / min\\)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999593007867263},{"cnt":[[1211,725],[1289,725],[1289,762],[1211,762]],"region":{"top_left_x":1211,"top_left_y":724,"width":79,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5e7c70ad58f4f7faadf4a9bb89c35de","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"24\\%","text_display":"24\\%","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[765,770],[887,770],[887,811],[765,811]],"region":{"top_left_x":765,"top_left_y":770,"width":122,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67d552e778034cafb8e63f83afb8d2b1","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"\\(2 L / min\\)","text_display":"\\(2 L / min\\)","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999593007867263},{"cnt":[[1211,770],[1287,770],[1287,811],[1211,811]],"region":{"top_left_x":1211,"top_left_y":770,"width":77,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66008f96059a4d6ba913fb9eb31976be","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"28\\%","text_display":"28\\%","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[765,822],[887,822],[887,859],[765,859]],"region":{"top_left_x":765,"top_left_y":822,"width":122,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fb72d300a974d46bba70b76a1858605","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"\\(3 L / min\\)","text_display":"\\(3 L / min\\)","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1211,822],[1289,822],[1289,861],[1211,861]],"region":{"top_left_x":1211,"top_left_y":822,"width":79,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9e31b89810b4438a542708eac94e410","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"32\\%","text_display":"32\\%","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[765,872],[887,872],[887,907],[765,907]],"region":{"top_left_x":765,"top_left_y":871,"width":122,"height":36},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ff5681332704763b1c58fab68e63939","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"\\(4 L / min\\)","text_display":"\\(4 L / min\\)","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1211,870],[1287,870],[1287,909],[1211,909]],"region":{"top_left_x":1211,"top_left_y":869,"width":77,"height":40},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4175568c0a86473b83a6cac68fa597d3","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"36\\%","text_display":"36\\%","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[765,922],[889,922],[889,959],[765,959]],"region":{"top_left_x":765,"top_left_y":921,"width":124,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce53764c1e054b9897516983d6886726","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"\\(5 L / min\\)","text_display":"\\(5 L / min\\)","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999185833438636},{"cnt":[[1211,922],[1289,922],[1289,961],[1211,961]],"region":{"top_left_x":1211,"top_left_y":921,"width":79,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38f350a4ef934f07911692cbbcf17184","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"40\\%","text_display":"40\\%","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[765,969],[889,969],[889,1006],[765,1006]],"region":{"top_left_x":765,"top_left_y":969,"width":124,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d5bba49301a44c285c00e64bfddae1c","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"\\(6 L / min\\)","text_display":"\\(6 L / min\\)","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1211,969],[1289,969],[1289,1008],[1211,1008]],"region":{"top_left_x":1211,"top_left_y":969,"width":79,"height":40},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51877602b32745b29eccabd3899f20c7","type":"simple_cell","conversion_output":false,"parent_id":"636c79d1c2b8448ba789798788647e7e","text":"44\\%","text_display":"44\\%","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[305,1068],[1674,1068],[1674,1113],[305,1113]],"region":{"top_left_x":305,"top_left_y":1067,"width":1369,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d3b59138147410887e71ac9569c4b26","type":"text","conversion_output":true,"text":"- ABG 30 minutes after extubation only if clinical suspicion of poor respiratory function","text_display":"\n- ABG 30 minutes after extubation only if clinical suspicion of poor respiratory function","confidence":1,"confidence_rate":1},{"cnt":[[305,1109],[827,1109],[827,1154],[305,1154]],"region":{"top_left_x":305,"top_left_y":1108,"width":523,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71382c029cc546f6b983da2e544c359b","type":"text","conversion_output":true,"text":"- Continuous SpO2 Monitoring","text_display":"\n- Continuous SpO2 Monitoring","confidence":1,"confidence_rate":1},{"cnt":[[305,1152],[1811,1152],[1811,1197],[305,1197]],"region":{"top_left_x":305,"top_left_y":1151,"width":1507,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbfa625f40c448c9af1ad919ff5fb8ed","type":"text","conversion_output":true,"text":"- Observation and assessment of patient for respiratory distress or increased work of breathing","text_display":"\n- Observation and assessment of patient for respiratory distress or increased work of breathing","confidence":1,"confidence_rate":1},{"cnt":[[305,1195],[1880,1195],[1880,1240],[305,1240]],"region":{"top_left_x":305,"top_left_y":1194,"width":1575,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2414d9c5202340bebfe3241c746d117f","type":"text","conversion_output":true,"text":"- Incentive Spirometry (IS) every \\(30 min \\times 4\\), every 1 hour \\(\\times 4\\); then hourly while awake or more often,","text_display":"\n- Incentive Spirometry (IS) every \\(30 min \\times 4\\), every 1 hour \\(\\times 4\\); then hourly while awake or more often,","confidence":0.9528970718383789,"confidence_rate":0.9995877056531984},{"cnt":[[370,1233],[565,1233],[565,1274],[370,1274]],"region":{"top_left_x":369,"top_left_y":1233,"width":197,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee93df8bb27445c3ad552b6b5a7de04b","type":"text","conversion_output":true,"text":"as indicated","text_display":" as indicated","confidence":1,"confidence_rate":1},{"cnt":[[305,1276],[1665,1276],[1665,1321],[305,1321]],"region":{"top_left_x":305,"top_left_y":1276,"width":1361,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dded5c254d7349919440274bb4aea783","type":"text","conversion_output":true,"text":"- Dangling on edge of bed within 2 hours should be performed unless contraindicated","text_display":"\n- Dangling on edge of bed within 2 hours should be performed unless contraindicated","confidence":1,"confidence_rate":1},{"cnt":[[305,1319],[1661,1319],[1661,1364],[305,1364]],"region":{"top_left_x":305,"top_left_y":1319,"width":1356,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a7f19791ecc451d996cbbb23ed2a3aa","type":"text","conversion_output":true,"text":"- Patient/Family instruction in use of splint pillow during coughing and deep breathing","text_display":"\n- Patient/Family instruction in use of splint pillow during coughing and deep breathing","confidence":1,"confidence_rate":1},{"cnt":[[305,1362],[1558,1362],[1558,1405],[305,1405]],"region":{"top_left_x":305,"top_left_y":1362,"width":1253,"height":44},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"910b68db602145dc80fb965428d52cad","type":"text","conversion_output":true,"text":"- Patient instruction in pain control as an important part of improved ventilation","text_display":"\n- Patient instruction in pain control as an important part of improved ventilation","confidence":1,"confidence_rate":1},{"cnt":[[305,1403],[1622,1403],[1622,1450],[305,1450]],"region":{"top_left_x":305,"top_left_y":1402,"width":1318,"height":49},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e9111205b974ce2962d586b61d490e2","type":"text","conversion_output":true,"text":"- Position with HOB \\(>45\\), or up in chair, for enhanced respiratory pattern/coughing","text_display":"\n- Position with HOB \\(>45\\), or up in chair, for enhanced respiratory pattern/coughing","confidence":0.9965848922729492,"confidence_rate":0.9999624078217871},{"cnt":[[305,1446],[1061,1446],[1061,1491],[305,1491]],"region":{"top_left_x":305,"top_left_y":1445,"width":757,"height":47},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31f54c01541f45a197855791651e2083","type":"text","conversion_output":true,"text":"- Weaning of FiO 2 as tolerated to \\(SpO _{2}>92 \\%\\)","text_display":"\n- Weaning of FiO 2 as tolerated to \\(SpO _{2}>92 \\%\\)","confidence":0.99462890625,"confidence_rate":0.9999131397413998},{"cnt":[[1830,2363],[1886,2363],[1886,2402],[1830,2402]],"region":{"top_left_x":1830,"top_left_y":2363,"width":57,"height":39},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e21863ac4cbb414eac2448b52c4e37c0","type":"page_info","conversion_output":false,"text":"21","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-21","page":21,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"130e21d986fd4d4aafc7ba8d708e6b9e","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1764,168],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1520,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"092269edfbcb41579c915a1759ec16e2","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89671960096b471b9731f148d97cac34","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[488,305],[1682,305],[1682,363],[488,363]],"region":{"top_left_x":487,"top_left_y":305,"width":1196,"height":59},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60ff0e21b98c4651a4c877f41f62d634","type":"section_header","conversion_output":false,"children_ids":["ce6e0ffe59f54a22a9945b5517f4d467"],"text":"","text_display":""},{"cnt":[[494,312],[1676,312],[1676,357],[494,357]],"region":{"top_left_x":494,"top_left_y":311,"width":1182,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce6e0ffe59f54a22a9945b5517f4d467","type":"text","conversion_output":true,"parent_id":"60ff0e21b98c4651a4c877f41f62d634","text":"INSTITUTIONAL INTRAVENOUS DRUG ADMINISTRATION GUIDELINES","text_display":"\n\n\\section*{INSTITUTIONAL INTRAVENOUS DRUG ADMINISTRATION GUIDELINES}","confidence":1,"confidence_rate":1},{"cnt":[[365,438],[1738,438],[1738,582],[365,582]],"region":{"top_left_x":365,"top_left_y":438,"width":1374,"height":145},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a007c90cc5ab4c4f8928c4b147719863","type":"table","conversion_output":true,"text":"\\begin{tabular}{ll} \nVersion Date: & \\(01 / 2002\\) \\\\\nRevision Date: & \\(11 / 2014\\) \\\\\nMedication: & Dexmedetomidine Hydrochloride (PRECEDEX)\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{ll} \nVersion Date: & \\(01 / 2002\\) \\\\\nRevision Date: & \\(11 / 2014\\) \\\\\nMedication: & Dexmedetomidine Hydrochloride (PRECEDEX)\n\\end{tabular}","confidence":0.85986328125,"confidence_rate":0.9988822408796335},{"cnt":[[1830,2363],[1882,2363],[1882,2402],[1830,2402]],"region":{"top_left_x":1830,"top_left_y":2363,"width":53,"height":39},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32532b46debd496b932b8234a3e5903c","type":"page_info","conversion_output":false,"text":"22","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-22","page":22,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5e610d84a2c4485a5fe0e7c2b5af568","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,168],[1762,168],[1762,208],[245,208]],"region":{"top_left_x":244,"top_left_y":167,"width":1518,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c70f4d9efec4137b0b6692398ac56cf","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,251],[245,251]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcd6e85d69874cef85182e2ce71c757b","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[374,301],[1721,301],[1721,1946],[374,1946]],"region":{"top_left_x":373,"top_left_y":300,"width":1348,"height":1647},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"088b644dd2b04aa2b3f2d3995f11e152","type":"table","conversion_output":true,"children_ids":["1542c3303a9d4689ad2ef2d86d91e938","e4d918f63c0243d5a782ccb88262e324","70517744419b45d8a99b92b38fe7e010","35e2fed811b840729b8819933e09574f","97fac4626ffc4ea3bd1564d0580f44ed","c3680f492894446fb01cda39c885a729","16d1bbe915f645348cfdbcc46b5211f7","28fdb4d4e4b54b9ba7a97448891228ad","5c6b437ba6e74d27b8aa8451baa14374","1b6a6b0b3b654994952ad1d79d31027e","74699cbda386431aa6778496af796d32","b6e2d49276214852b18b6af355364b42","a1ecb9b6791e4daa9fac47a272857a86","511d68924f8a443c9d20dc82bbfae8a5","74a9687e51c04af79dd8637b9b8f8caf","413d35d97ab643b4ab73291fcd400414"],"text":"\\begin{tabular}{|l|}\n\\hline ![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-22.jpg?height=133\\&width=104\\&top_left_y=308\\&top_left_x=390) \\\\\n\\hline \\begin{tabular}{l}\nTherapeutic category: Alpha 2-Adrenergic Agonist Sedative \\\\\nTherapeutic Use: Short term sedation of mechanically ventilated patients, or selected non-intubated patients in the intensive care setting, adjunct treatment for alcohol withdrawal in the intensive care setting.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nIV PUSH \\\\\nNot recommended\n\\end{tabular} \\\\\n\\hline \\\\\n\\hline \\begin{tabular}{l}\nINTERMITTENT INFUSION \\\\\nNot recommended\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nCLINICAL CONSIDERATIONS \\\\\n- IV access: May be administered peripherally or centrally \\\\\n- IV infusion device: Sigma infusion pump required \\\\\n- Infusion related considerations: \\\\\n- Continuous infusion should be titrated in \\(0.1-0.2 mcg / kg / hr\\) increments no more than every 30 minutes. \\\\\n- Acute agitation while titrating infusion should be managed with either midazolam or fentanyl bolus dosing -Do not bolus dose dexmedetomidine for ICU sedation \\\\\n- When converting a patient from other continuous sedation, dexmedetomidine should be initiated at 0.4 \\(mcg / kg / hr\\) for \\(1-2\\) hours before attempting weaning of other sedative agents. \\\\\n- Patients may remain on dexmedetomidine after extubation, (or to avoid intubation in alcohol withdrawal) but care should be taken to monitor hemodynamics and respiratory status (as below) \\\\\n- Monitoring: \\\\\n- Patient should be continuously monitored for heart rate and blood pressure \\\\\n- Dexmedetomidine may prolong PR interval. \\\\\n- While dexmedetomidine does not cause respiratory depression, cases of obstructive apnea have been reported with high doses. Monitor continuous oxygen saturation while infusing \\\\\n- Level of sedation. (RASS) should be monitored at least every 4 hours \\\\\n- Common adverse effects include bradycardia and hypotension.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nCOMPATIBILITY \\\\\n- Compatible with \\(0.9 \\%\\) Sodium Chloride \\\\\n- Dexmedetomidine standard concentration: \\(400 mcg / 100 mL\\) \\\\\n- Stable for 48 hours at room temperature. Do not refrigerate\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nWRITTEN BY: John Marshall, PharmD \\\\\nAPPROVED: Pharmacy and Therapeutics Committee \\\\\nDATE: January 2002 \\\\\nREVISED: November 2014 \\\\\nSTATUS: Formulary\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|}\n\\hline ![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-22.jpg?height=133\\&width=104\\&top_left_y=308\\&top_left_x=390) \\\\\n\\hline \\begin{tabular}{l}\nTherapeutic category: Alpha 2-Adrenergic Agonist Sedative \\\\\nTherapeutic Use: Short term sedation of mechanically ventilated patients, or selected non-intubated patients in the intensive care setting, adjunct treatment for alcohol withdrawal in the intensive care setting.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nIV PUSH \\\\\nNot recommended\n\\end{tabular} \\\\\n\\hline \\\\\n\\hline \\begin{tabular}{l}\nINTERMITTENT INFUSION \\\\\nNot recommended\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nCLINICAL CONSIDERATIONS \\\\\n- IV access: May be administered peripherally or centrally \\\\\n- IV infusion device: Sigma infusion pump required \\\\\n- Infusion related considerations: \\\\\n- Continuous infusion should be titrated in \\(0.1-0.2 mcg / kg / hr\\) increments no more than every 30 minutes. \\\\\n- Acute agitation while titrating infusion should be managed with either midazolam or fentanyl bolus dosing -Do not bolus dose dexmedetomidine for ICU sedation \\\\\n- When converting a patient from other continuous sedation, dexmedetomidine should be initiated at 0.4 \\(mcg / kg / hr\\) for \\(1-2\\) hours before attempting weaning of other sedative agents. \\\\\n- Patients may remain on dexmedetomidine after extubation, (or to avoid intubation in alcohol withdrawal) but care should be taken to monitor hemodynamics and respiratory status (as below) \\\\\n- Monitoring: \\\\\n- Patient should be continuously monitored for heart rate and blood pressure \\\\\n- Dexmedetomidine may prolong PR interval. \\\\\n- While dexmedetomidine does not cause respiratory depression, cases of obstructive apnea have been reported with high doses. Monitor continuous oxygen saturation while infusing \\\\\n- Level of sedation. (RASS) should be monitored at least every 4 hours \\\\\n- Common adverse effects include bradycardia and hypotension.\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nCOMPATIBILITY \\\\\n- Compatible with \\(0.9 \\%\\) Sodium Chloride \\\\\n- Dexmedetomidine standard concentration: \\(400 mcg / 100 mL\\) \\\\\n- Stable for 48 hours at room temperature. Do not refrigerate\n\\end{tabular} \\\\\n\\hline \\begin{tabular}{l}\nWRITTEN BY: John Marshall, PharmD \\\\\nAPPROVED: Pharmacy and Therapeutics Committee \\\\\nDATE: January 2002 \\\\\nREVISED: November 2014 \\\\\nSTATUS: Formulary\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0,"confidence_rate":0},{"cnt":[[382,303],[1703,303],[1703,1947],[382,1947]],"region":{"top_left_x":381,"top_left_y":303,"width":1323,"height":1644},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1542c3303a9d4689ad2ef2d86d91e938","type":"table_column","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[376,305],[1720,305],[1720,484],[376,484]],"region":{"top_left_x":376,"top_left_y":305,"width":1345,"height":179},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e4d918f63c0243d5a782ccb88262e324","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,566],[1722,566],[1722,709],[373,709]],"region":{"top_left_x":373,"top_left_y":566,"width":1350,"height":144},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"70517744419b45d8a99b92b38fe7e010","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,702],[1720,702],[1720,773],[373,773]],"region":{"top_left_x":373,"top_left_y":702,"width":1348,"height":71},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"35e2fed811b840729b8819933e09574f","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,762],[1720,762],[1720,840],[373,840]],"region":{"top_left_x":373,"top_left_y":762,"width":1348,"height":78},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"97fac4626ffc4ea3bd1564d0580f44ed","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,829],[1720,829],[1720,914],[373,914]],"region":{"top_left_x":373,"top_left_y":829,"width":1348,"height":85},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c3680f492894446fb01cda39c885a729","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,912],[1720,912],[1720,1630],[373,1630]],"region":{"top_left_x":373,"top_left_y":911,"width":1348,"height":720},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"16d1bbe915f645348cfdbcc46b5211f7","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,1635],[1720,1635],[1720,1783],[373,1783]],"region":{"top_left_x":373,"top_left_y":1635,"width":1348,"height":149},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"28fdb4d4e4b54b9ba7a97448891228ad","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[373,1773],[1722,1771],[1722,1945],[373,1947]],"region":{"top_left_x":372,"top_left_y":1771,"width":1351,"height":177},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5c6b437ba6e74d27b8aa8451baa14374","type":"table_row","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","text":"","text_display":""},{"cnt":[[387,309],[1659,309],[1659,474],[387,474]],"region":{"top_left_x":386,"top_left_y":308,"width":1273,"height":166},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b6a6b0b3b654994952ad1d79d31027e","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["c724f9187ea54f198a7905b821a1623b"],"text":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-22.jpg?height=133\\&width=104\\&top_left_y=308\\&top_left_x=390)","text_display":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-22.jpg?height=133\\&width=104\\&top_left_y=308\\&top_left_x=390)","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0,"confidence_rate":0},{"cnt":[[390,309],[493,309],[493,441],[390,441]],"region":{"top_left_x":390,"top_left_y":308,"width":104,"height":133},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c724f9187ea54f198a7905b821a1623b","type":"diagram","conversion_output":false,"parent_id":"1b6a6b0b3b654994952ad1d79d31027e","text":"","text_display":"![](https://cdn.mathpix.com/cropped/6c46927b-ae99-4127-9213-1a3afb06732f-22.jpg?height=133\\&width=104\\&top_left_y=308\\&top_left_x=390)"},{"cnt":[[387,572],[1650,572],[1650,709],[387,709]],"region":{"top_left_x":386,"top_left_y":571,"width":1265,"height":139},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74699cbda386431aa6778496af796d32","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["428c10832d4e44289be924e15ea054dd","f779aa069c3149daa051d05516db90f6","af02b54368a64bcf804ee9264e9a1117"],"text":"\\begin{tabular}{l}\nTherapeutic category: Alpha 2-Adrenergic Agonist Sedative \\\\\nTherapeutic Use: Short term sedation of mechanically ventilated patients, or selected non-intubated patients in the intensive care setting, adjunct treatment for alcohol withdrawal in the intensive care setting.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nTherapeutic category: Alpha 2-Adrenergic Agonist Sedative \\\\\nTherapeutic Use: Short term sedation of mechanically ventilated patients, or selected non-intubated patients in the intensive care setting, adjunct treatment for alcohol withdrawal in the intensive care setting.\n\\end{tabular}","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9970703125,"confidence_rate":0.9999842259984174},{"cnt":[[394,575],[1078,575],[1078,611],[394,611]],"region":{"top_left_x":393,"top_left_y":575,"width":685,"height":37},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"428c10832d4e44289be924e15ea054dd","type":"text","conversion_output":false,"parent_id":"74699cbda386431aa6778496af796d32","text":"Therapeutic category: Alpha 2-Adrenergic Agonist Sedative","text_display":"Therapeutic category: Alpha 2-Adrenergic Agonist Sedative","confidence":0.9970703125,"confidence_rate":0.9999526787417056},{"cnt":[[392,639],[1647,639],[1647,673],[392,673]],"region":{"top_left_x":391,"top_left_y":638,"width":1256,"height":35},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f779aa069c3149daa051d05516db90f6","type":"text","conversion_output":false,"parent_id":"74699cbda386431aa6778496af796d32","text":"Therapeutic Use: Short term sedation of mechanically ventilated patients, or selected non-intubated patients in the","text_display":"\nTherapeutic Use: Short term sedation of mechanically ventilated patients, or selected non-intubated patients in the","confidence":1,"confidence_rate":1},{"cnt":[[390,673],[1385,673],[1385,707],[390,707]],"region":{"top_left_x":390,"top_left_y":672,"width":996,"height":36},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af02b54368a64bcf804ee9264e9a1117","type":"text","conversion_output":false,"parent_id":"74699cbda386431aa6778496af796d32","text":"intensive care setting, adjunct treatment for alcohol withdrawal in the intensive care setting.","text_display":" intensive care setting, adjunct treatment for alcohol withdrawal in the intensive care setting.","confidence":1,"confidence_rate":1},{"cnt":[[388,704],[1110,704],[1110,771],[388,771]],"region":{"top_left_x":388,"top_left_y":703,"width":723,"height":68},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6e2d49276214852b18b6af355364b42","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["368e01202a0a4ff0b28057016db2098b","cdbd19e920094a668cf460c25ea7508b"],"text":"\\begin{tabular}{l}\nIV PUSH \\\\\nNot recommended\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nIV PUSH \\\\\nNot recommended\n\\end{tabular}","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[988,706],[1107,706],[1107,735],[988,735]],"region":{"top_left_x":988,"top_left_y":705,"width":119,"height":30},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"368e01202a0a4ff0b28057016db2098b","type":"text","conversion_output":false,"parent_id":"b6e2d49276214852b18b6af355364b42","text":"IV PUSH","text_display":"IV PUSH","confidence":1,"confidence_rate":1},{"cnt":[[390,737],[602,737],[602,769],[390,769]],"region":{"top_left_x":390,"top_left_y":736,"width":212,"height":34},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdbd19e920094a668cf460c25ea7508b","type":"text","conversion_output":false,"parent_id":"b6e2d49276214852b18b6af355364b42","text":"Not recommended","text_display":"\nNot recommended","confidence":1,"confidence_rate":1},{"cnt":[[387,768],[1226,768],[1226,920],[387,920]],"region":{"top_left_x":386,"top_left_y":767,"width":840,"height":154},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1ecb9b6791e4daa9fac47a272857a86","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["def9956fffee4f43b30518cf5ce90a82","f8b75415228b4df18d16261faecae26b"],"text":"\\begin{tabular}{l}\nINTERMITTENT INFUSION \\\\\nNot recommended\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nINTERMITTENT INFUSION \\\\\nNot recommended\n\\end{tabular}","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[865,771],[1229,771],[1229,800],[865,800]],"region":{"top_left_x":864,"top_left_y":770,"width":365,"height":31},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"def9956fffee4f43b30518cf5ce90a82","type":"text","conversion_output":false,"parent_id":"a1ecb9b6791e4daa9fac47a272857a86","text":"INTERMITTENT INFUSION","text_display":"INTERMITTENT INFUSION","confidence":1,"confidence_rate":1},{"cnt":[[390,802],[602,802],[602,833],[390,833]],"region":{"top_left_x":390,"top_left_y":801,"width":212,"height":32},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b75415228b4df18d16261faecae26b","type":"text","conversion_output":false,"parent_id":"a1ecb9b6791e4daa9fac47a272857a86","text":"Not recommended","text_display":"\nNot recommended","confidence":1,"confidence_rate":1},{"cnt":[[435,915],[1703,915],[1703,1617],[435,1617]],"region":{"top_left_x":434,"top_left_y":915,"width":1270,"height":702},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"511d68924f8a443c9d20dc82bbfae8a5","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["9a8d2f904b534e8f82540985fda347e2","5bf0e73204f24c8b91998851c9bf8bf3","ae6e17326a7343fe80c637ea47451189","1a8f3d5c17914c00bc96cfbb625cef7d","366103ccc8e247fc89d9ca15413f4239","dd9f3ba19c0846578a607bab0a339a36","83bfa856ff9d49eab35b1f1d1d3dcd56","30c30c1c27724f1eb9e84c15d4287cf3","9d80fbcefd324707a53f739d8d223de8","79955ecba8ac498bb8eac9ccd5ae2216","aa082faec0734ce2b5b075146ca7be59","061cf4a67c934c258602442230c6886b","c0f574758e9545d6aeaff31b57d25b11","2fb3be837a50498f94f02acc0779b37d","439cab821e154459bbdd01a00a3cac08","2bb8211b78fe4891b362d9b1c9d529ce","5f46fe532ce9452ca6557a70fbe6a96f","ffcdc24351614698a49553b052330dd6"],"text":"\\begin{tabular}{l}\nCLINICAL CONSIDERATIONS \\\\\n- IV access: May be administered peripherally or centrally \\\\\n- IV infusion device: Sigma infusion pump required \\\\\n- Infusion related considerations: \\\\\n- Continuous infusion should be titrated in \\(0.1-0.2 mcg / kg / hr\\) increments no more than every 30 minutes. \\\\\n- Acute agitation while titrating infusion should be managed with either midazolam or fentanyl bolus dosing -Do not bolus dose dexmedetomidine for ICU sedation \\\\\n- When converting a patient from other continuous sedation, dexmedetomidine should be initiated at 0.4 \\(mcg / kg / hr\\) for \\(1-2\\) hours before attempting weaning of other sedative agents. \\\\\n- Patients may remain on dexmedetomidine after extubation, (or to avoid intubation in alcohol withdrawal) but care should be taken to monitor hemodynamics and respiratory status (as below) \\\\\n- Monitoring: \\\\\n- Patient should be continuously monitored for heart rate and blood pressure \\\\\n- Dexmedetomidine may prolong PR interval. \\\\\n- While dexmedetomidine does not cause respiratory depression, cases of obstructive apnea have been reported with high doses. Monitor continuous oxygen saturation while infusing \\\\\n- Level of sedation. (RASS) should be monitored at least every 4 hours \\\\\n- Common adverse effects include bradycardia and hypotension.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nCLINICAL CONSIDERATIONS \\\\\n- IV access: May be administered peripherally or centrally \\\\\n- IV infusion device: Sigma infusion pump required \\\\\n- Infusion related considerations: \\\\\n- Continuous infusion should be titrated in \\(0.1-0.2 mcg / kg / hr\\) increments no more than every 30 minutes. \\\\\n- Acute agitation while titrating infusion should be managed with either midazolam or fentanyl bolus dosing -Do not bolus dose dexmedetomidine for ICU sedation \\\\\n- When converting a patient from other continuous sedation, dexmedetomidine should be initiated at 0.4 \\(mcg / kg / hr\\) for \\(1-2\\) hours before attempting weaning of other sedative agents. \\\\\n- Patients may remain on dexmedetomidine after extubation, (or to avoid intubation in alcohol withdrawal) but care should be taken to monitor hemodynamics and respiratory status (as below) \\\\\n- Monitoring: \\\\\n- Patient should be continuously monitored for heart rate and blood pressure \\\\\n- Dexmedetomidine may prolong PR interval. \\\\\n- While dexmedetomidine does not cause respiratory depression, cases of obstructive apnea have been reported with high doses. Monitor continuous oxygen saturation while infusing \\\\\n- Level of sedation. (RASS) should be monitored at least every 4 hours \\\\\n- Common adverse effects include bradycardia and hypotension.\n\\end{tabular}","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99169921875,"confidence_rate":0.9999877610420606},{"cnt":[[849,919],[1248,919],[1248,951],[849,951]],"region":{"top_left_x":849,"top_left_y":918,"width":399,"height":34},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a8d2f904b534e8f82540985fda347e2","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"CLINICAL CONSIDERATIONS","text_display":"CLINICAL CONSIDERATIONS","confidence":1,"confidence_rate":1},{"cnt":[[443,950],[1103,950],[1103,989],[443,989]],"region":{"top_left_x":443,"top_left_y":949,"width":661,"height":41},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bf0e73204f24c8b91998851c9bf8bf3","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- IV access: May be administered peripherally or centrally","text_display":"\n- IV access: May be administered peripherally or centrally","confidence":1,"confidence_rate":1},{"cnt":[[442,998],[1035,998],[1035,1034],[442,1034]],"region":{"top_left_x":441,"top_left_y":997,"width":594,"height":37},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae6e17326a7343fe80c637ea47451189","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- IV infusion device: Sigma infusion pump required","text_display":"\n- IV infusion device: Sigma infusion pump required","confidence":1,"confidence_rate":1},{"cnt":[[442,1046],[844,1046],[844,1079],[442,1079]],"region":{"top_left_x":441,"top_left_y":1045,"width":403,"height":34},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a8f3d5c17914c00bc96cfbb625cef7d","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Infusion related considerations:","text_display":"\n- Infusion related considerations:","confidence":1,"confidence_rate":1},{"cnt":[[493,1094],[1676,1094],[1676,1130],[493,1130]],"region":{"top_left_x":493,"top_left_y":1094,"width":1183,"height":37},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"366103ccc8e247fc89d9ca15413f4239","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Continuous infusion should be titrated in \\(0.1-0.2 mcg / kg / hr\\) increments no more than every 30 minutes.","text_display":"\n- Continuous infusion should be titrated in \\(0.1-0.2 mcg / kg / hr\\) increments no more than every 30 minutes.","confidence":0.994631290435791,"confidence_rate":0.999955876605639},{"cnt":[[493,1128],[1702,1128],[1702,1165],[493,1165]],"region":{"top_left_x":493,"top_left_y":1128,"width":1209,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd9f3ba19c0846578a607bab0a339a36","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Acute agitation while titrating infusion should be managed with either midazolam or fentanyl bolus dosing","text_display":"\n- Acute agitation while titrating infusion should be managed with either midazolam or fentanyl bolus dosing","confidence":0.9990234375,"confidence_rate":0.999991276469766},{"cnt":[[541,1159],[1176,1159],[1176,1192],[541,1192]],"region":{"top_left_x":541,"top_left_y":1159,"width":635,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83bfa856ff9d49eab35b1f1d1d3dcd56","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"-Do not bolus dose dexmedetomidine for ICU sedation","text_display":" -Do not bolus dose dexmedetomidine for ICU sedation","confidence":0.9960973262786865,"confidence_rate":0.9999301754909825},{"cnt":[[493,1190],[1657,1190],[1657,1226],[493,1226]],"region":{"top_left_x":493,"top_left_y":1190,"width":1164,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30c30c1c27724f1eb9e84c15d4287cf3","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- When converting a patient from other continuous sedation, dexmedetomidine should be initiated at 0.4","text_display":"\n- When converting a patient from other continuous sedation, dexmedetomidine should be initiated at 0.4","confidence":1,"confidence_rate":1},{"cnt":[[545,1225],[1375,1225],[1375,1259],[545,1259]],"region":{"top_left_x":544,"top_left_y":1224,"width":832,"height":36},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d80fbcefd324707a53f739d8d223de8","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"\\(mcg / kg / hr\\) for \\(1-2\\) hours before attempting weaning of other sedative agents.","text_display":" \\(mcg / kg / hr\\) for \\(1-2\\) hours before attempting weaning of other sedative agents.","confidence":0.99169921875,"confidence_rate":0.9999084061226785},{"cnt":[[493,1256],[1684,1256],[1684,1292],[493,1292]],"region":{"top_left_x":493,"top_left_y":1255,"width":1192,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79955ecba8ac498bb8eac9ccd5ae2216","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Patients may remain on dexmedetomidine after extubation, (or to avoid intubation in alcohol withdrawal)","text_display":"\n- Patients may remain on dexmedetomidine after extubation, (or to avoid intubation in alcohol withdrawal)","confidence":1,"confidence_rate":1},{"cnt":[[541,1287],[1458,1287],[1458,1324],[541,1324]],"region":{"top_left_x":541,"top_left_y":1286,"width":917,"height":39},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa082faec0734ce2b5b075146ca7be59","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"but care should be taken to monitor hemodynamics and respiratory status (as below)","text_display":" but care should be taken to monitor hemodynamics and respiratory status (as below)","confidence":1,"confidence_rate":1},{"cnt":[[442,1352],[619,1352],[619,1388],[442,1388]],"region":{"top_left_x":441,"top_left_y":1351,"width":178,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"061cf4a67c934c258602442230c6886b","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Monitoring:","text_display":"\n- Monitoring:","confidence":1,"confidence_rate":1},{"cnt":[[493,1417],[1356,1417],[1356,1453],[493,1453]],"region":{"top_left_x":493,"top_left_y":1417,"width":864,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0f574758e9545d6aeaff31b57d25b11","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Patient should be continuously monitored for heart rate and blood pressure","text_display":"\n- Patient should be continuously monitored for heart rate and blood pressure","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[493,1450],[1045,1450],[1045,1484],[493,1484]],"region":{"top_left_x":493,"top_left_y":1449,"width":553,"height":36},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fb3be837a50498f94f02acc0779b37d","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Dexmedetomidine may prolong PR interval.","text_display":"\n- Dexmedetomidine may prolong PR interval.","confidence":1,"confidence_rate":1},{"cnt":[[493,1482],[1676,1482],[1676,1515],[493,1515]],"region":{"top_left_x":493,"top_left_y":1482,"width":1183,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"439cab821e154459bbdd01a00a3cac08","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- While dexmedetomidine does not cause respiratory depression, cases of obstructive apnea have been","text_display":"\n- While dexmedetomidine does not cause respiratory depression, cases of obstructive apnea have been","confidence":1,"confidence_rate":1},{"cnt":[[541,1513],[1442,1513],[1442,1550],[541,1550]],"region":{"top_left_x":541,"top_left_y":1513,"width":902,"height":37},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bb8211b78fe4891b362d9b1c9d529ce","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"reported with high doses. Monitor continuous oxygen saturation while infusing","text_display":" reported with high doses. Monitor continuous oxygen saturation while infusing","confidence":1,"confidence_rate":1},{"cnt":[[493,1546],[1299,1546],[1299,1580],[493,1580]],"region":{"top_left_x":493,"top_left_y":1546,"width":807,"height":35},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f46fe532ce9452ca6557a70fbe6a96f","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Level of sedation. (RASS) should be monitored at least every 4 hours","text_display":"\n- Level of sedation. (RASS) should be monitored at least every 4 hours","confidence":1,"confidence_rate":1},{"cnt":[[493,1579],[1227,1579],[1227,1611],[493,1611]],"region":{"top_left_x":493,"top_left_y":1578,"width":735,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffcdc24351614698a49553b052330dd6","type":"text","conversion_output":false,"parent_id":"511d68924f8a443c9d20dc82bbfae8a5","text":"- Common adverse effects include bradycardia and hypotension.","text_display":"\n- Common adverse effects include bradycardia and hypotension.","confidence":1,"confidence_rate":1},{"cnt":[[383,1641],[1169,1641],[1169,1783],[383,1783]],"region":{"top_left_x":383,"top_left_y":1640,"width":786,"height":144},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"74a9687e51c04af79dd8637b9b8f8caf","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["a4c5dc892b2549f999ddbea080e1d463","d55609d53c554e8893bc5147cfdac40c","f8b3655604e24af9ab6ffd82e071a2cb","95868abb04534ed68b7f90e6c841bd69"],"text":"\\begin{tabular}{l}\nCOMPATIBILITY \\\\\n- Compatible with \\(0.9 \\%\\) Sodium Chloride \\\\\n- Dexmedetomidine standard concentration: \\(400 mcg / 100 mL\\) \\\\\n- Stable for 48 hours at room temperature. Do not refrigerate\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nCOMPATIBILITY \\\\\n- Compatible with \\(0.9 \\%\\) Sodium Chloride \\\\\n- Dexmedetomidine standard concentration: \\(400 mcg / 100 mL\\) \\\\\n- Stable for 48 hours at room temperature. Do not refrigerate\n\\end{tabular}","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.990234375,"confidence_rate":0.9999572425377885},{"cnt":[[930,1644],[1165,1644],[1165,1677],[930,1677]],"region":{"top_left_x":929,"top_left_y":1644,"width":237,"height":33},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4c5dc892b2549f999ddbea080e1d463","type":"text","conversion_output":false,"parent_id":"74a9687e51c04af79dd8637b9b8f8caf","text":"COMPATIBILITY","text_display":"COMPATIBILITY","confidence":1,"confidence_rate":1},{"cnt":[[438,1677],[938,1677],[938,1713],[438,1713]],"region":{"top_left_x":438,"top_left_y":1676,"width":501,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d55609d53c554e8893bc5147cfdac40c","type":"text","conversion_output":false,"parent_id":"74a9687e51c04af79dd8637b9b8f8caf","text":"- Compatible with \\(0.9 \\%\\) Sodium Chloride","text_display":"\n- Compatible with \\(0.9 \\%\\) Sodium Chloride","confidence":0.99951171875,"confidence_rate":0.9999893826542317},{"cnt":[[438,1713],[1140,1713],[1140,1749],[438,1749]],"region":{"top_left_x":438,"top_left_y":1712,"width":702,"height":37},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b3655604e24af9ab6ffd82e071a2cb","type":"text","conversion_output":false,"parent_id":"74a9687e51c04af79dd8637b9b8f8caf","text":"- Dexmedetomidine standard concentration: \\(400 mcg / 100 mL\\)","text_display":"\n- Dexmedetomidine standard concentration: \\(400 mcg / 100 mL\\)","confidence":0.990234375,"confidence_rate":0.9998466739205149},{"cnt":[[438,1747],[1145,1747],[1145,1780],[438,1780]],"region":{"top_left_x":438,"top_left_y":1747,"width":707,"height":33},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95868abb04534ed68b7f90e6c841bd69","type":"text","conversion_output":false,"parent_id":"74a9687e51c04af79dd8637b9b8f8caf","text":"- Stable for 48 hours at room temperature. Do not refrigerate","text_display":"\n- Stable for 48 hours at room temperature. Do not refrigerate","confidence":0.99951171875,"confidence_rate":0.9999929217569623},{"cnt":[[380,1775],[1031,1775],[1031,1943],[380,1943]],"region":{"top_left_x":379,"top_left_y":1774,"width":653,"height":170},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"413d35d97ab643b4ab73291fcd400414","type":"complex_cell","conversion_output":false,"parent_id":"088b644dd2b04aa2b3f2d3995f11e152","children_ids":["57357da8f94f4ac494470fe40f64ff1d","81c323c56cf942e09a3f3df337a666bb","46284dafafe94e6c966069d58e264a34","d5db735ac4fc4b64af6b7941ec1d5027","503bb2219973476bad67411452b6310a"],"text":"\\begin{tabular}{l}\nWRITTEN BY: John Marshall, PharmD \\\\\nAPPROVED: Pharmacy and Therapeutics Committee \\\\\nDATE: January 2002 \\\\\nREVISED: November 2014 \\\\\nSTATUS: Formulary\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nWRITTEN BY: John Marshall, PharmD \\\\\nAPPROVED: Pharmacy and Therapeutics Committee \\\\\nDATE: January 2002 \\\\\nREVISED: November 2014 \\\\\nSTATUS: Formulary\n\\end{tabular}","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999962430801487},{"cnt":[[390,1780],[856,1780],[856,1814],[390,1814]],"region":{"top_left_x":390,"top_left_y":1779,"width":466,"height":36},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57357da8f94f4ac494470fe40f64ff1d","type":"text","conversion_output":false,"parent_id":"413d35d97ab643b4ab73291fcd400414","text":"WRITTEN BY: John Marshall, PharmD","text_display":"WRITTEN BY: John Marshall, PharmD","confidence":1,"confidence_rate":1},{"cnt":[[390,1809],[1028,1809],[1028,1847],[390,1847]],"region":{"top_left_x":390,"top_left_y":1809,"width":638,"height":38},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81c323c56cf942e09a3f3df337a666bb","type":"text","conversion_output":false,"parent_id":"413d35d97ab643b4ab73291fcd400414","text":"APPROVED: Pharmacy and Therapeutics Committee","text_display":"\nAPPROVED: Pharmacy and Therapeutics Committee","confidence":1,"confidence_rate":1},{"cnt":[[390,1843],[746,1843],[746,1883],[390,1883]],"region":{"top_left_x":390,"top_left_y":1843,"width":356,"height":40},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46284dafafe94e6c966069d58e264a34","type":"text","conversion_output":false,"parent_id":"413d35d97ab643b4ab73291fcd400414","text":"DATE: January 2002","text_display":"\nDATE: January 2002","confidence":1,"confidence_rate":1},{"cnt":[[390,1874],[777,1874],[777,1910],[390,1910]],"region":{"top_left_x":390,"top_left_y":1874,"width":387,"height":37},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5db735ac4fc4b64af6b7941ec1d5027","type":"text","conversion_output":false,"parent_id":"413d35d97ab643b4ab73291fcd400414","text":"REVISED: November 2014","text_display":"\nREVISED: November 2014","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[390,1905],[718,1905],[718,1941],[390,1941]],"region":{"top_left_x":390,"top_left_y":1905,"width":329,"height":37},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"503bb2219973476bad67411452b6310a","type":"text","conversion_output":false,"parent_id":"413d35d97ab643b4ab73291fcd400414","text":"STATUS: Formulary","text_display":"\nSTATUS: Formulary","confidence":1,"confidence_rate":1},{"cnt":[[374,1942],[522,1942],[522,1974],[374,1974]],"region":{"top_left_x":373,"top_left_y":1942,"width":150,"height":33},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1e8ee974998440288b9bdb38881831b9","type":"section_header","conversion_output":false,"children_ids":["1e8b7d3c34f04d26bd87f135c3061750"],"text":"","text_display":""},{"cnt":[[378,1942],[522,1942],[522,1970],[378,1970]],"region":{"top_left_x":378,"top_left_y":1942,"width":145,"height":29},"line":57,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1e8b7d3c34f04d26bd87f135c3061750","type":"text","conversion_output":true,"parent_id":"1e8ee974998440288b9bdb38881831b9","text":"References:","text_display":"\n\n\\section*{References:}","confidence":0.99951171875,"confidence_rate":0.9999694754347522},{"cnt":[[374,1972],[1678,1972],[1678,2013],[374,2013]],"region":{"top_left_x":373,"top_left_y":1972,"width":1305,"height":42},"line":58,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8fd66e80475341c99b29daf59a14de49","type":"text","conversion_output":true,"text":"Shehabi Y et al. Clinical Application, The Use of Dexmedetomidine in Intensive Care Sedation. Crit Care \\& Shock","text_display":"\n\nShehabi Y et al. Clinical Application, The Use of Dexmedetomidine in Intensive Care Sedation. Crit Care \\& Shock","confidence":0.7409887725418685,"confidence_rate":0.9975458867180381},{"cnt":[[374,2007],[647,2007],[647,2043],[374,2043]],"region":{"top_left_x":373,"top_left_y":2006,"width":274,"height":38},"line":59,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0e3debc7d6e64f25a5bc878f336126b1","type":"text","conversion_output":true,"text":"2010 Vol.13:(2); 40-50","text_display":" 2010 Vol.13:(2); 40-50","confidence":0.9682769775390625,"confidence_rate":0.9987608799281829},{"cnt":[[1833,2363],[1882,2363],[1882,2402],[1833,2402]],"region":{"top_left_x":1832,"top_left_y":2363,"width":51,"height":39},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"deedb88f861f476fa63e5f6bfa2a1209","type":"page_info","conversion_output":false,"text":"23","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"6c46927b-ae99-4127-9213-1a3afb06732f-23","page":23,"lines":[{"cnt":[[245,125],[1721,125],[1721,168],[245,168]],"region":{"top_left_x":244,"top_left_y":124,"width":1477,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee7f7719cf01493db1740fd7c7e9f783","type":"text","conversion_output":true,"text":"Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","text_display":"\n\nEffect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or","confidence":1,"confidence_rate":1},{"cnt":[[245,165],[1764,165],[1764,208],[245,208]],"region":{"top_left_x":244,"top_left_y":165,"width":1520,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eae3a32856e44c3683459942170df210","type":"text","conversion_output":true,"text":"Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","text_display":" Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac","confidence":1,"confidence_rate":1},{"cnt":[[245,206],[1033,206],[1033,249],[245,249]],"region":{"top_left_x":244,"top_left_y":206,"width":790,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9d8abb6c6c54c10a4eb847d713313c2","type":"text","conversion_output":true,"text":"Surgery: The DEXACET Randomized Clinical Trial","text_display":" Surgery: The DEXACET Randomized Clinical Trial","confidence":1,"confidence_rate":1},{"cnt":[[241,245],[496,245],[496,294],[241,294]],"region":{"top_left_x":240,"top_left_y":244,"width":257,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6827d78042c43fbb95bfe1d137790be","type":"section_header","conversion_output":false,"children_ids":["415ee0feaf9543a191850b9784509278"],"text":"","text_display":""},{"cnt":[[245,249],[492,249],[492,290],[245,290]],"region":{"top_left_x":244,"top_left_y":249,"width":248,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"415ee0feaf9543a191850b9784509278","type":"text","conversion_output":true,"parent_id":"d6827d78042c43fbb95bfe1d137790be","text":"REFERENCES","text_display":"\n\n\\section*{REFERENCES}","confidence":0.99951171875,"confidence_rate":0.9999674404968649},{"cnt":[[245,339],[1833,339],[1833,387],[245,387]],"region":{"top_left_x":244,"top_left_y":339,"width":1589,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22fd2704ac0644eeb058e30b89f1f1e8","type":"text","conversion_output":true,"text":"1. Rudolph JL, Jones RN, Levkoff SE, et al. Derivation and validation of a preoperative prediction rule","text_display":"\n1. Rudolph JL, Jones RN, Levkoff SE, et al. Derivation and validation of a preoperative prediction rule","confidence":1,"confidence_rate":1},{"cnt":[[305,382],[1351,382],[1351,425],[305,425]],"region":{"top_left_x":305,"top_left_y":382,"width":1047,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0dbe0516ed9c475389672a24af06e1e3","type":"text","conversion_output":true,"text":"for delirium after cardiac surgery. Circulation. 2009;119(2):229-236.","text_display":" for delirium after cardiac surgery. Circulation. 2009;119(2):229-236.","confidence":1,"confidence_rate":1},{"cnt":[[245,421],[1519,421],[1519,466],[245,466]],"region":{"top_left_x":244,"top_left_y":421,"width":1275,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a57885326be94840a37a39cb2722e3a5","type":"text","conversion_output":true,"text":"2. Inouye SK. Delirium in older persons. N Engl J Med. 2006;354(11):1157-1165.","text_display":"\n2. Inouye SK. Delirium in older persons. N Engl J Med. 2006;354(11):1157-1165.","confidence":0.9902389049530029,"confidence_rate":0.9998818256960044},{"cnt":[[245,464],[1848,464],[1848,505],[245,505]],"region":{"top_left_x":244,"top_left_y":464,"width":1604,"height":41},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"559cb885ff7541d381313a4870f86b3e","type":"text","conversion_output":true,"text":"3. Saczynski JS, Marcantonio ER, Quach L, et al. Cognitive trajectories after postoperative delirium. N","text_display":"\n3. Saczynski JS, Marcantonio ER, Quach L, et al. Cognitive trajectories after postoperative delirium. N","confidence":0.9985356330871582,"confidence_rate":0.9999864312018168},{"cnt":[[305,503],[806,503],[806,544],[305,544]],"region":{"top_left_x":305,"top_left_y":502,"width":501,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50688d01a2054e62ad297a995bd7f5aa","type":"text","conversion_output":true,"text":"Engl J Med. 2012;367(1):30-39.","text_display":" Engl J Med. 2012;367(1):30-39.","confidence":0.99853515625,"confidence_rate":0.9999581175147387},{"cnt":[[245,541],[1841,541],[1841,587],[245,587]],"region":{"top_left_x":244,"top_left_y":541,"width":1598,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"214f7352d3fb4a79b3aa49296a8ab67e","type":"text","conversion_output":true,"text":"4. Lin YY, He B, Chen J, Wang ZN. Can dexmedetomidine be a safe and efficacious sedative agent in","text_display":"\n4. Lin YY, He B, Chen J, Wang ZN. Can dexmedetomidine be a safe and efficacious sedative agent in","confidence":1,"confidence_rate":1},{"cnt":[[305,580],[1480,580],[1480,625],[305,625]],"region":{"top_left_x":305,"top_left_y":580,"width":1176,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75035ae9125a49fca0ee09ded60dc88e","type":"text","conversion_output":true,"text":"post-cardiac surgery patients? a meta-analysis. Crit Care. 2012;16(5):R169.","text_display":" post-cardiac surgery patients? a meta-analysis. Crit Care. 2012;16(5):R169.","confidence":1,"confidence_rate":1},{"cnt":[[245,623],[1803,623],[1803,664],[245,664]],"region":{"top_left_x":244,"top_left_y":623,"width":1559,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b30f0d206a1e4d4d832bd1bdcb156bc3","type":"text","conversion_output":true,"text":"5. Dasta JF, Jacobi J, Sesti AM, McLaughlin TP. Addition of dexmedetomidine to standard sedation","text_display":"\n5. Dasta JF, Jacobi J, Sesti AM, McLaughlin TP. Addition of dexmedetomidine to standard sedation","confidence":1,"confidence_rate":1},{"cnt":[[305,662],[1766,662],[1766,707],[305,707]],"region":{"top_left_x":305,"top_left_y":661,"width":1462,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"282adaa28b7449948213e68976c5bf1b","type":"text","conversion_output":true,"text":"regimens after cardiac surgery: an outcomes analysis. Pharmacotherapy. 2006;26(6):798-805.","text_display":" regimens after cardiac surgery: an outcomes analysis. Pharmacotherapy. 2006;26(6):798-805.","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1876,700],[1876,746],[245,746]],"region":{"top_left_x":244,"top_left_y":700,"width":1632,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69201d6d81ec4a3cbecf8ed9ec2fd6eb","type":"text","conversion_output":true,"text":"6. Shehabi Y, Grant P, Wolfenden H, et al. Prevalence of delirium with dexmedetomidine compared with","text_display":"\n6. Shehabi Y, Grant P, Wolfenden H, et al. Prevalence of delirium with dexmedetomidine compared with","confidence":0.99853515625,"confidence_rate":0.9999860389766703},{"cnt":[[305,743],[1783,743],[1783,784],[305,784]],"region":{"top_left_x":305,"top_left_y":743,"width":1479,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08abe88faa2e4c10a2ee4191c000ddad","type":"text","conversion_output":true,"text":"morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine","text_display":" morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine","confidence":1,"confidence_rate":1},{"cnt":[[305,782],[1601,782],[1601,827],[305,827]],"region":{"top_left_x":305,"top_left_y":782,"width":1296,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"965edd5aeca04acdbd80c0774022af99","type":"text","conversion_output":true,"text":"COmpared to Morphine-DEXCOM Study). Anesthesiology. 2009;111(5):1075-1084.","text_display":" COmpared to Morphine-DEXCOM Study). Anesthesiology. 2009;111(5):1075-1084.","confidence":0.9970703125,"confidence_rate":0.9999628616081941},{"cnt":[[245,821],[1858,821],[1858,866],[245,866]],"region":{"top_left_x":244,"top_left_y":820,"width":1615,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8040387489f46878529cd5b798c6311","type":"text","conversion_output":true,"text":"7. Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, Reitz BA. Dexmedetomidine and the","text_display":"\n7. Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, Reitz BA. Dexmedetomidine and the","confidence":1,"confidence_rate":1},{"cnt":[[305,864],[1777,864],[1777,904],[305,904]],"region":{"top_left_x":305,"top_left_y":863,"width":1472,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec3bb3ba82374707b8fd342a94f5e47e","type":"text","conversion_output":true,"text":"reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009;50(3):206-217.","text_display":" reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009;50(3):206-217.","confidence":0.9912109375,"confidence_rate":0.999910833125869},{"cnt":[[245,902],[1835,902],[1835,947],[245,947]],"region":{"top_left_x":244,"top_left_y":902,"width":1591,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16b8f6b45f8d4e56b6e9ef6892b28ca4","type":"text","conversion_output":true,"text":"8. Corbett SM, Rebuck JA, Greene CM, et al. Dexmedetomidine does not improve patient satisfaction","text_display":"\n8. Corbett SM, Rebuck JA, Greene CM, et al. Dexmedetomidine does not improve patient satisfaction","confidence":1,"confidence_rate":1},{"cnt":[[305,941],[1798,941],[1798,986],[305,986]],"region":{"top_left_x":305,"top_left_y":941,"width":1494,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6a1bdbb8b734fd0a1e5de6a15dba220","type":"text","conversion_output":true,"text":"when compared with propofol during mechanical ventilation. Crit Care Med. 2005;33(5):940-945.","text_display":" when compared with propofol during mechanical ventilation. Crit Care Med. 2005;33(5):940-945.","confidence":1,"confidence_rate":1},{"cnt":[[245,982],[1790,982],[1790,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":981,"width":1546,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee16ea0c54374aa69d57fa393ca42305","type":"text","conversion_output":true,"text":"9. Holmer Pettersson P, Jakobsson J, Owall A. Plasma concentrations following repeated rectal or","text_display":"\n9. Holmer Pettersson P, Jakobsson J, Owall A. Plasma concentrations following repeated rectal or","confidence":1,"confidence_rate":1},{"cnt":[[305,1023],[1669,1023],[1669,1068],[305,1068]],"region":{"top_left_x":305,"top_left_y":1022,"width":1365,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09c720de7ddf4fa78e5f2a376fa8d4bb","type":"text","conversion_output":true,"text":"intravenous administration of paracetamol after heart surgery. Acta Anaesthesiol Scand.","text_display":" intravenous administration of paracetamol after heart surgery. Acta Anaesthesiol Scand.","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[305,1061],[629,1061],[629,1106],[305,1106]],"region":{"top_left_x":305,"top_left_y":1061,"width":325,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0c5d6aa67de40638207aed5018b1ec4","type":"text","conversion_output":true,"text":"2006;50(6):673-677.","text_display":" 2006;50(6):673-677.","confidence":0.98828125,"confidence_rate":0.999508955778694},{"cnt":[[1833,2363],[1882,2363],[1882,2402],[1833,2402]],"region":{"top_left_x":1832,"top_left_y":2363,"width":51,"height":39},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2d2f80cc0ed46918c34e4f7e7d1a80a","type":"page_info","conversion_output":false,"text":"24","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}
\ No newline at end of file