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is an international, multicenter, randomized controlled trial","text_display":"\nANDROMEDA-SHOCK is an international, multicenter, randomized controlled trial","confidence":1,"confidence_rate":1},{"cnt":[[292,552],[1717,552],[1717,599],[292,599]],"region":{"top_left_x":292,"top_left_y":552,"width":1425,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4845594bc0564bcb8e3b37a86f42cee4","type":"text","conversion_output":true,"parent_id":"37358ea486b24657b806b09675f8696a","text":"comparing peripheral perfusion-targeted resuscitation (PPTR) versus lactate-targeted","text_display":" comparing peripheral perfusion-targeted resuscitation (PPTR) versus 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report the statistical analysis plan for the ANDROMEDA-SHOCK trial.","text_display":"\n\nTo report the statistical analysis plan for the ANDROMEDA-SHOCK 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AND RATIONALE","text_display":"\n\n\\section*{BACKGROUND AND RATIONALE}","confidence":1,"confidence_rate":1},{"cnt":[[288,455],[1835,455],[1835,505],[288,505]],"region":{"top_left_x":287,"top_left_y":455,"width":1548,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"476549473d9148e688bcac6fd88a6b4f","type":"text","conversion_output":true,"text":"Early recognition of tissue hypoperfusion and its reversion in septic shock are key factors to","text_display":"\n\nEarly recognition of tissue hypoperfusion and its reversion in septic shock are key factors to","confidence":1,"confidence_rate":1},{"cnt":[[288,546],[1738,546],[1738,604],[288,604]],"region":{"top_left_x":287,"top_left_y":545,"width":1452,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82ca146d47ba4e9aaefde5b36b24116e","type":"text","conversion_output":true,"text":"improve survival. \\({ }^{1}\\) Hyperlactatemia has been traditionally 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(PPTR) versus lactate-targeted","confidence":1,"confidence_rate":1},{"cnt":[[288,1878],[1777,1878],[1777,1931],[288,1931]],"region":{"top_left_x":287,"top_left_y":1877,"width":1490,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61714a735cfe4f87a1cf620362d0855f","type":"text","conversion_output":true,"text":"resuscitation (LTR) in patients with septic shock, to test the hypothesis that resuscitation","text_display":" resuscitation (LTR) in patients with septic shock, to test the hypothesis that resuscitation","confidence":1,"confidence_rate":1},{"cnt":[[288,1977],[1704,1977],[1704,2030],[288,2030]],"region":{"top_left_x":287,"top_left_y":1976,"width":1417,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"955054ee5d0f49aeb71f3bbe34f059bf","type":"text","conversion_output":true,"text":"aimed at peripheral perfusion will be associated with lower morbidity and mortality.","text_display":" aimed at peripheral perfusion will be associated with lower morbidity and mortality.","confidence":1,"confidence_rate":1},{"cnt":[[288,2110],[1783,2110],[1783,2163],[288,2163]],"region":{"top_left_x":287,"top_left_y":2109,"width":1497,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c810a8685c93479d9c2073904e261345","type":"text","conversion_output":true,"text":"This article outlines the statistical analysis plan (SAP) for ANDROMEDA-SHOCK with","text_display":"\n\nThis article outlines the statistical analysis plan (SAP) for ANDROMEDA-SHOCK with","confidence":1,"confidence_rate":1},{"cnt":[[288,2209],[1768,2209],[1768,2262],[288,2262]],"region":{"top_left_x":287,"top_left_y":2208,"width":1482,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f486582ddfaa4a199328a2fa65085fb1","type":"text","conversion_output":true,"text":"the aim of preventing statistical analysis bias arising from exploratory analyses 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The SAP was developed following appropriate guidelines \\({ }^{9}\\) prior","text_display":" study results are known. The SAP was developed following appropriate guidelines \\({ }^{9}\\) prior","confidence":1,"confidence_rate":1},{"cnt":[[288,2402],[1128,2402],[1128,2454],[288,2454]],"region":{"top_left_x":287,"top_left_y":2401,"width":841,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0fe081c04b545ef832e73d08eed60cc","type":"text","conversion_output":true,"text":"to locking the trial database and starting analyses.","text_display":" to locking the trial database and starting 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Objective","text_display":"\n\n\\section*{Primary Objective}","confidence":1,"confidence_rate":1},{"cnt":[[292,438],[1738,438],[1738,490],[292,490]],"region":{"top_left_x":292,"top_left_y":438,"width":1447,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b659aef4a4934087928930f5707e164c","type":"text","conversion_output":true,"text":"Our primary objective is to determine if PPTR is associated with lower mortality rates","text_display":"\n\nOur primary objective is to determine if PPTR is associated with lower mortality rates","confidence":1,"confidence_rate":1},{"cnt":[[288,533],[1225,533],[1225,587],[288,587]],"region":{"top_left_x":287,"top_left_y":532,"width":938,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c417436ff4d4c80be2634d966467573","type":"text","conversion_output":true,"text":"within 28-day than a LTR in patients with septic shock.","text_display":" within 28-day than a LTR in patients with septic shock.","confidence":0.99658203125,"confidence_rate":0.9999429379056106},{"cnt":[[288,670],[677,670],[677,728],[288,728]],"region":{"top_left_x":287,"top_left_y":670,"width":390,"height":59},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6539140292a417aa0e20a5ec2b1530f","type":"section_header","conversion_output":false,"children_ids":["79a646de8ab2451abbf0062651931678"],"text":"","text_display":""},{"cnt":[[292,675],[672,675],[672,724],[292,724]],"region":{"top_left_x":292,"top_left_y":674,"width":381,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79a646de8ab2451abbf0062651931678","type":"text","conversion_output":true,"parent_id":"e6539140292a417aa0e20a5ec2b1530f","text":"Secondary objectives","text_display":"\n\n\\section*{Secondary 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Ecuador,","confidence":1,"confidence_rate":1},{"cnt":[[288,1781],[1680,1781],[1680,1835],[288,1835]],"region":{"top_left_x":287,"top_left_y":1781,"width":1394,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5cb7c549dcc41198c5a21ffd8b0f2d0","type":"text","conversion_output":true,"text":"Colombia and Uruguay. The trial protocol (version 1.0 from December, 2016) was","text_display":" Colombia and Uruguay. The trial protocol (version 1.0 from December, 2016) was","confidence":1,"confidence_rate":1},{"cnt":[[288,1878],[1734,1878],[1734,1931],[288,1931]],"region":{"top_left_x":287,"top_left_y":1877,"width":1447,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c48cc63a79d74f9da55a3fa23d040e9b","type":"text","conversion_output":true,"text":"submitted and is under review in another Journal, is registered with ClinicalTrials.gov","text_display":" submitted and is under review in another Journal, is registered with ClinicalTrials.gov","confidence":1,"confidence_rate":1},{"cnt":[[288,1972],[1674,1972],[1674,2026],[288,2026]],"region":{"top_left_x":287,"top_left_y":1972,"width":1387,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"513bd134fb24493fa209e20b10ad9eb3","type":"text","conversion_output":true,"text":"(NCT03078712), and was approved by the Ethics Committee of all the participant","text_display":" (NCT03078712), and was approved by the Ethics Committee of all the participant","confidence":1,"confidence_rate":1},{"cnt":[[288,2067],[1429,2067],[1429,2121],[288,2121]],"region":{"top_left_x":287,"top_left_y":2066,"width":1142,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afc3ac0880b8464491347f95813def1b","type":"text","conversion_output":true,"text":"institutions. The main study interventions are summarized on Fig 1.","text_display":" institutions. The main study interventions are summarized on Fig 1.","confidence":1,"confidence_rate":1},{"cnt":[[288,2209],[677,2209],[677,2258],[288,2258]],"region":{"top_left_x":287,"top_left_y":2208,"width":390,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daa0a789808b4974a862032d1b4ebb90","type":"section_header","conversion_output":false,"children_ids":["6fd341113bbe47e1bfeda788d7a69b1d"],"text":"","text_display":""},{"cnt":[[288,2211],[672,2211],[672,2254],[288,2254]],"region":{"top_left_x":287,"top_left_y":2210,"width":386,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fd341113bbe47e1bfeda788d7a69b1d","type":"text","conversion_output":true,"parent_id":"daa0a789808b4974a862032d1b4ebb90","text":"RANDOMIZATION","text_display":"\n\n\\section*{RANDOMIZATION}","confidence":1,"confidence_rate":1},{"cnt":[[288,2303],[1798,2303],[1798,2357],[288,2357]],"region":{"top_left_x":287,"top_left_y":2303,"width":1512,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25ac199382364eec8e48b58e70b855e5","type":"text","conversion_output":true,"text":"Eligible patients will be randomly allocated to PPTR or LTR groups. PPTR will be aimed","text_display":"\n\nEligible patients will be randomly allocated to PPTR or LTR groups. PPTR will be aimed","confidence":1,"confidence_rate":1},{"cnt":[[288,2402],[1790,2402],[1790,2451],[288,2451]],"region":{"top_left_x":287,"top_left_y":2401,"width":1503,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5e3b97685f8456d8e1863ad80ec9809","type":"text","conversion_output":true,"text":"to normalize CRT while LTR will target lactate normalization or a decreasing rate higher","text_display":" to normalize CRT while LTR will target lactate normalization or a decreasing rate higher","confidence":0.998046875,"confidence_rate":0.9999789783410032},{"cnt":[[1807,2582],[1835,2582],[1835,2628],[1807,2628]],"region":{"top_left_x":1806,"top_left_y":2582,"width":29,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4964f0171f642d89619d73c0479030e","type":"page_info","conversion_output":false,"text":"5","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-06","page":6,"lines":[{"cnt":[[288,245],[1626,245],[1626,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1340,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"822853faa1bc4b28853f422fa70c1134","type":"text","conversion_output":true,"text":"than \\(20 \\%\\) per 2 hours of lactate levels during the 8 -hours of the study period. A","text_display":"\nthan \\(20 \\%\\) per 2 hours of lactate levels during the 8 -hours of the study period. 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Allocation concealment will be maintained by means of","text_display":" eight (without stratification). Allocation concealment will be maintained by means of","confidence":1,"confidence_rate":1},{"cnt":[[288,627],[1727,627],[1727,685],[288,685]],"region":{"top_left_x":287,"top_left_y":627,"width":1441,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"990205e619d84797a91a172fb82aec27","type":"text","conversion_output":true,"text":"central randomization. Investigators at the sites will call a representative of the Study","text_display":" central randomization. Investigators at the sites will call a representative of the Study","confidence":1,"confidence_rate":1},{"cnt":[[288,722],[1807,722],[1807,780],[288,780]],"region":{"top_left_x":287,"top_left_y":721,"width":1520,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b0f262505634e579926ea8880f18c84","type":"text","conversion_output":true,"text":"Coordinating Center (SCC) available 24-hour / 7-days through a dedicated phone number.","text_display":" Coordinating Center (SCC) available 24-hour / 7-days through a dedicated phone number.","confidence":0.9712052345275879,"confidence_rate":0.9996789804505642},{"cnt":[[288,819],[1783,819],[1783,874],[288,874]],"region":{"top_left_x":287,"top_left_y":818,"width":1497,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2918f82472d54768b2ee2f0e65f1d8ca","type":"text","conversion_output":true,"text":"The group to which the patient is allocated will only be disclosed after the information is","text_display":" The group to which the patient is allocated will only be disclosed after the information is","confidence":1,"confidence_rate":1},{"cnt":[[286,915],[1813,915],[1813,973],[286,973]],"region":{"top_left_x":285,"top_left_y":915,"width":1529,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d723f8c557ec487b96a3cc5278118d62","type":"text","conversion_output":true,"text":"recorded by the SCC. Such a measure prevents the investigator and the medical team from","text_display":" recorded by the SCC. Such a measure prevents the investigator and the medical team from","confidence":1,"confidence_rate":1},{"cnt":[[286,1010],[1384,1010],[1384,1070],[286,1070]],"region":{"top_left_x":285,"top_left_y":1009,"width":1099,"height":61},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"998d30a5af42443691b9ea791523794b","type":"text","conversion_output":true,"text":"predicting to which treatment group the patient will be allocated.","text_display":" predicting to which treatment group the patient will be allocated.","confidence":1,"confidence_rate":1},{"cnt":[[279,1143],[812,1143],[812,1205],[279,1205]],"region":{"top_left_x":279,"top_left_y":1142,"width":534,"height":64},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5ae2b7044fe4f74932003831f2d3891","type":"section_header","conversion_output":false,"children_ids":["918c9ab2fa4e4c28b3de52f669e47d52"],"text":"","text_display":""},{"cnt":[[288,1147],[804,1147],[804,1197],[288,1197]],"region":{"top_left_x":287,"top_left_y":1147,"width":517,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"918c9ab2fa4e4c28b3de52f669e47d52","type":"text","conversion_output":true,"parent_id":"a5ae2b7044fe4f74932003831f2d3891","text":"STUDY INTERVENTIONS","text_display":"\n\n\\section*{STUDY INTERVENTIONS}","confidence":1,"confidence_rate":1},{"cnt":[[288,1242],[1841,1242],[1841,1300],[288,1300]],"region":{"top_left_x":287,"top_left_y":1241,"width":1555,"height":59},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfea166fed1f48598629471bec2dc544","type":"text","conversion_output":true,"text":"A sequential approach to resuscitation will be followed in both groups as shown in Fig 1.","text_display":"\n\nA sequential approach to resuscitation will be followed in both groups as shown in Fig 1.","confidence":1,"confidence_rate":1},{"cnt":[[288,1336],[1841,1336],[1841,1399],[288,1399]],"region":{"top_left_x":287,"top_left_y":1336,"width":1555,"height":63},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c60e6c6561a45d290d9666de6b310c6","type":"text","conversion_output":true,"text":"The intervention period will be extended for 8 hours after randomization. All other","text_display":" The intervention period will be extended for 8 hours after randomization. All other","confidence":1,"confidence_rate":1},{"cnt":[[288,1435],[1841,1435],[1841,1493],[288,1493]],"region":{"top_left_x":287,"top_left_y":1435,"width":1555,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"613ba058bdf441339f1d421ae4c31b89","type":"text","conversion_output":true,"text":"treatments, during the intervention period and after, will be at the discretion of the treating","text_display":" treatments, during the intervention period and after, will be at the discretion of the treating","confidence":1,"confidence_rate":1},{"cnt":[[288,1525],[1261,1525],[1261,1588],[288,1588]],"region":{"top_left_x":287,"top_left_y":1525,"width":975,"height":63},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b5498b8416f42d9ace8d74250a59288","type":"text","conversion_output":true,"text":"clinicians according to their local usual clinical practices.","text_display":" clinicians according to their local usual clinical practices.","confidence":1,"confidence_rate":1},{"cnt":[[288,1663],[1841,1663],[1841,1725],[288,1725]],"region":{"top_left_x":287,"top_left_y":1662,"width":1555,"height":64},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba6c78bc55a44ddfa93f250e33c921b5","type":"text","conversion_output":true,"text":"In the PPTR group, capillary refill time will be measured every 30 minutes until","text_display":"\n\nIn the PPTR group, capillary refill time will be measured every 30 minutes until","confidence":1,"confidence_rate":1},{"cnt":[[286,1762],[1841,1762],[1841,1824],[286,1824]],"region":{"top_left_x":285,"top_left_y":1761,"width":1557,"height":64},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24a9bee510d04a0a8b29f681511c22dd","type":"text","conversion_output":true,"text":"normalization and when normalized every 1 h until the end of the 8 h protocol. It is measured","text_display":" normalization and when normalized every 1 h until the end of the 8 h protocol. It is measured","confidence":1,"confidence_rate":1},{"cnt":[[288,1858],[1841,1858],[1841,1919],[288,1919]],"region":{"top_left_x":287,"top_left_y":1858,"width":1555,"height":61},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ff781ebe71e4ceb99c33806df223cfc","type":"text","conversion_output":true,"text":"by applying firm pressure to the ventral surface of the right index finger distal phalanx with","text_display":" by applying firm pressure to the ventral surface of the right index finger distal phalanx with","confidence":1,"confidence_rate":1},{"cnt":[[288,1953],[1841,1953],[1841,2013],[288,2013]],"region":{"top_left_x":287,"top_left_y":1952,"width":1555,"height":62},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d68f3afef764f4c9d463c2bac75099f","type":"text","conversion_output":true,"text":"a glass microscope slide. The pressure will be increased until the skin is blank and then","text_display":" a glass microscope slide. The pressure will be increased until the skin is blank and then","confidence":1,"confidence_rate":1},{"cnt":[[286,2050],[1837,2050],[1837,2108],[286,2108]],"region":{"top_left_x":285,"top_left_y":2049,"width":1552,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a06fb2ebcaf4726a88f307ef07cdfaf","type":"text","conversion_output":true,"text":"maintained for 10 seconds. The time for return of the normal skin color will be registered","text_display":" maintained for 10 seconds. The time for return of the normal skin color will be registered","confidence":1,"confidence_rate":1},{"cnt":[[286,2140],[1785,2140],[1785,2206],[286,2206]],"region":{"top_left_x":285,"top_left_y":2139,"width":1501,"height":68},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edfff18e6b7a46dbaa4bf4057506348a","type":"text","conversion_output":true,"text":"with a chronometer. A capillary refill time \\(>3\\) seconds will be considered as abnormal. \\({ }^{11}\\)","text_display":" with a chronometer. A capillary refill time \\(>3\\) seconds will be considered as abnormal. \\({ }^{11}\\)","confidence":1,"confidence_rate":1},{"cnt":[[288,2286],[1813,2286],[1813,2344],[288,2344]],"region":{"top_left_x":287,"top_left_y":2285,"width":1527,"height":59},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"266c27dda7f94cc3bf2dfd59e1cfa54c","type":"text","conversion_output":true,"text":"In the LRT group, lactate will be assessed every two hours during the 8 -hour study period.","text_display":"\n\nIn the LRT group, lactate will be assessed every two hours during the 8 -hour study period.","confidence":0.82666015625,"confidence_rate":0.9980790029960138},{"cnt":[[1805,2578],[1852,2578],[1852,2630],[1805,2630]],"region":{"top_left_x":1804,"top_left_y":2578,"width":48,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e211ca9864aa49ad9c03c84e36c1626d","type":"page_info","conversion_output":false,"text":"6","text_display":"","confidence":0.99951171875,"confidence_rate":0.99951171875}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-07","page":7,"lines":[{"cnt":[[288,245],[1837,245],[1837,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1550,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1e9b3c051cc49438421900663b6cb01","type":"text","conversion_output":true,"text":"Fluid responsiveness will be assessed using a structured approach outlined in the protocol,","text_display":"\n\nFluid responsiveness will be assessed using a structured approach outlined in the protocol,","confidence":1,"confidence_rate":1},{"cnt":[[288,339],[1837,339],[1837,397],[288,397]],"region":{"top_left_x":287,"top_left_y":339,"width":1550,"height":59},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d758fc2181e340eb99ea36d2c24efec3","type":"text","conversion_output":true,"text":"which includes several different predictors (passive leg-raising, end-expiratory occlusion","text_display":" which includes several different predictors (passive leg-raising, end-expiratory occlusion","confidence":1,"confidence_rate":1},{"cnt":[[288,436],[1837,436],[1837,492],[288,492]],"region":{"top_left_x":287,"top_left_y":436,"width":1550,"height":56},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfa68a7c4c084a21b0a975b0263f1f3f","type":"text","conversion_output":true,"text":"test, pulse pressure variation, respiratory variations of inferior vena cava, aortic velocity time","text_display":" test, pulse pressure variation, respiratory variations of inferior vena cava, aortic velocity time","confidence":1,"confidence_rate":1},{"cnt":[[288,529],[1837,529],[1837,587],[288,587]],"region":{"top_left_x":287,"top_left_y":528,"width":1550,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"566760a3ff4f455e91640ecf8270ac7a","type":"text","conversion_output":true,"text":"integral) customized according to patients' specific conditions (for example, whether patient","text_display":" integral) customized according to patients' specific conditions (for example, whether patient","confidence":0.9970715045928955,"confidence_rate":0.9999700740004459},{"cnt":[[288,627],[1835,627],[1835,683],[288,683]],"region":{"top_left_x":287,"top_left_y":627,"width":1548,"height":57},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7628f0d1658b4c5a973a2a2781fd218d","type":"text","conversion_output":true,"text":"is under mechanical ventilation, has irregular cardiac rhythm, ARDS/low respiratory-system","text_display":" is under mechanical ventilation, has irregular cardiac rhythm, ARDS/low respiratory-system","confidence":1,"confidence_rate":1},{"cnt":[[288,726],[518,726],[518,780],[288,780]],"region":{"top_left_x":287,"top_left_y":726,"width":231,"height":54},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eaae9ef4b1d4aefa378db85eea4a24f","type":"text","conversion_output":true,"text":"compliance).","text_display":" compliance).","confidence":1,"confidence_rate":1},{"cnt":[[288,862],[1841,862],[1841,917],[288,917]],"region":{"top_left_x":287,"top_left_y":861,"width":1555,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a55dbd54f6714a148fb566e628f5b3b8","type":"text","conversion_output":true,"text":"In patients predicted to be fluid-responsive, the first resuscitation step will be to administer","text_display":"\n\nIn patients predicted to be fluid-responsive, the first resuscitation step will be to administer","confidence":1,"confidence_rate":1},{"cnt":[[288,954],[1841,954],[1841,1012],[288,1012]],"region":{"top_left_x":287,"top_left_y":953,"width":1555,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f3e8c13f61443749adf0c4709ba87bd","type":"text","conversion_output":true,"text":"a fluid bolus ( 500 ml of crystalloids) every 30 min until normalizing capillary refill time in","text_display":" a fluid bolus ( 500 ml of crystalloids) every 30 min until normalizing capillary refill time in","confidence":0.98388671875,"confidence_rate":0.9998523335239619},{"cnt":[[288,1053],[1841,1053],[1841,1109],[288,1109]],"region":{"top_left_x":287,"top_left_y":1052,"width":1555,"height":57},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b242d65dfa1f4d6aab3adf8a0ea05743","type":"text","conversion_output":true,"text":"the PPTR group. In the LTR group, fluid boluses will be stopped if at 2 h lactate is normalized","text_display":" the PPTR group. In the LTR group, fluid boluses will be stopped if at 2 h lactate is normalized","confidence":0.8780481526628137,"confidence_rate":0.9987621587271679},{"cnt":[[288,1147],[1835,1147],[1835,1205],[288,1205]],"region":{"top_left_x":287,"top_left_y":1147,"width":1548,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb072da9e819499aacb72fc17134c278","type":"text","conversion_output":true,"text":"or has decreased \\(>20 \\%\\), or previously if after any of the fluid boluses, central venous pressure","text_display":" or has decreased \\(>20 \\%\\), or previously if after any of the fluid boluses, central venous pressure","confidence":0.9038553237915039,"confidence_rate":0.9990284917253076},{"cnt":[[288,1246],[1497,1246],[1497,1302],[288,1302]],"region":{"top_left_x":287,"top_left_y":1246,"width":1211,"height":56},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8485ff85de5246cf8156a96c3491fae9","type":"text","conversion_output":true,"text":"has increased \\(\\geq 5 mmHg\\) or the patients has become fluid unresponsive.","text_display":" has increased \\(\\geq 5 mmHg\\) or the patients has become fluid unresponsive.","confidence":1,"confidence_rate":1},{"cnt":[[288,1381],[1841,1381],[1841,1439],[288,1439]],"region":{"top_left_x":287,"top_left_y":1381,"width":1555,"height":59},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a923d72f37bf4fa7890bdd03fd24a8dc","type":"text","conversion_output":true,"text":"An open-label vasopressor test will be performed increasing mean arterial pressure up to 80-","text_display":"\n\nAn open-label vasopressor test will be performed increasing mean arterial pressure up to 80","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[288,1478],[1837,1478],[1837,1534],[288,1534]],"region":{"top_left_x":287,"top_left_y":1478,"width":1550,"height":56},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38709e79bc9e43cd86e41147fd209ee6","type":"text","conversion_output":true,"text":"85 mmHg by using progressive incremental doses of norepinephrine in patients with previous","text_display":"85 mmHg by using progressive incremental doses of norepinephrine in patients with previous","confidence":1,"confidence_rate":1},{"cnt":[[288,1573],[1837,1573],[1837,1631],[288,1631]],"region":{"top_left_x":287,"top_left_y":1572,"width":1550,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"930307e2e443488e82825fdf45ad7cb3","type":"text","conversion_output":true,"text":"history of chronic hypertension (as defined by previous use of anti-hypertensive medications","text_display":" history of chronic hypertension (as defined by previous use of anti-hypertensive medications","confidence":1,"confidence_rate":1},{"cnt":[[288,1669],[1837,1669],[1837,1725],[288,1725]],"region":{"top_left_x":287,"top_left_y":1669,"width":1550,"height":57},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3402eb78cc7140d087d9f368c4ea9561","type":"text","conversion_output":true,"text":"and medical history) and persistently abnormal capillary refill time or unfulfilled lactate goals","text_display":" and medical history) and persistently abnormal capillary refill time or unfulfilled lactate goals","confidence":1,"confidence_rate":1},{"cnt":[[288,1766],[1841,1766],[1841,1820],[288,1820]],"region":{"top_left_x":287,"top_left_y":1766,"width":1555,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03c1f4cade9e4c1f90b476aec195842b","type":"text","conversion_output":true,"text":"accompanied by a fluid unresponsive state. Parameters will be reassessed one hour after in","text_display":" accompanied by a fluid unresponsive state. Parameters will be reassessed one hour after in","confidence":1,"confidence_rate":1},{"cnt":[[288,1861],[1841,1861],[1841,1919],[288,1919]],"region":{"top_left_x":287,"top_left_y":1860,"width":1555,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03e658bdc2154585a550047b26940bfe","type":"text","conversion_output":true,"text":"the PPTR and two hours after in the LTR. If after the vasopressor test, capillary refill time","text_display":" the PPTR and two hours after in the LTR. If after the vasopressor test, capillary refill time","confidence":1,"confidence_rate":1},{"cnt":[[288,1955],[1841,1955],[1841,2013],[288,2013]],"region":{"top_left_x":287,"top_left_y":1955,"width":1555,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8b2c12ecd8948979674e4dd7572b363","type":"text","conversion_output":true,"text":"improves, and lactate goals are achieved in PPTR and LTR respectively, norepinephrine will","text_display":" improves, and lactate goals are achieved in PPTR and LTR respectively, norepinephrine will","confidence":1,"confidence_rate":1},{"cnt":[[288,2052],[1841,2052],[1841,2108],[288,2108]],"region":{"top_left_x":287,"top_left_y":2051,"width":1555,"height":57},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fee336c3a7f54674a218df0d57fa08df","type":"text","conversion_output":true,"text":"be titrated to maintain this new mean arterial pressures goal throughout the study period. If","text_display":" be titrated to maintain this new mean arterial pressures goal throughout the study period. If","confidence":1,"confidence_rate":1},{"cnt":[[286,2148],[1841,2148],[1841,2206],[286,2206]],"region":{"top_left_x":285,"top_left_y":2148,"width":1557,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dd5f0ef191d44748ca22f264b0217e7","type":"text","conversion_output":true,"text":"goals are not achieved despite increasing mean arterial pressure, or norepinephrine dose is","text_display":" goals are not achieved despite increasing mean arterial pressure, or norepinephrine dose is","confidence":1,"confidence_rate":1},{"cnt":[[286,2243],[1841,2243],[1841,2301],[286,2301]],"region":{"top_left_x":285,"top_left_y":2242,"width":1557,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7d8ea5f19f04755b529716c56aea59d","type":"text","conversion_output":true,"text":"higher than \\(0.8 mcg / kg / min\\) or adverse effects are observed (heart rate \\(>140 ppm\\),","text_display":" higher than \\(0.8 mcg / kg / min\\) or adverse effects are observed (heart rate \\(>140 ppm\\),","confidence":0.998046875,"confidence_rate":0.9999808331754918},{"cnt":[[286,2342],[1841,2342],[1841,2396],[286,2396]],"region":{"top_left_x":285,"top_left_y":2341,"width":1557,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03672cca139243b9ab0389185c1523c3","type":"text","conversion_output":true,"text":"arrhythmias, or evident cardiac ischemia), norepinephrine dose will be reduced to the level","text_display":" arrhythmias, or evident cardiac ischemia), norepinephrine dose will be reduced to the level","confidence":1,"confidence_rate":1},{"cnt":[[286,2436],[1489,2436],[1489,2494],[286,2494]],"region":{"top_left_x":285,"top_left_y":2436,"width":1204,"height":59},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67bfd73e12bd46f8a5cae94289e32a82","type":"text","conversion_output":true,"text":"before the vasopressor test, and the protocol will move to the next step.","text_display":" before the vasopressor test, and the protocol will move to the next step.","confidence":1,"confidence_rate":1},{"cnt":[[1805,2582],[1839,2582],[1839,2628],[1805,2628]],"region":{"top_left_x":1804,"top_left_y":2582,"width":36,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf94e64c65e940c8ac497c14f76d31b1","type":"page_info","conversion_output":false,"text":"7","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-08","page":8,"lines":[{"cnt":[[288,245],[1837,245],[1837,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1550,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e97de69bb07345eeb725d405abf4b6c7","type":"text","conversion_output":true,"text":"An open-label test of dobutamine at fixed \\(5 mcg / kg / min\\) or milrinone at fixed 0.25","text_display":"\n\nAn open-label test of dobutamine at fixed \\(5 mcg / kg / min\\) or milrinone at fixed 0.25","confidence":0.9956088066101074,"confidence_rate":0.9999541587278539},{"cnt":[[286,339],[1837,339],[1837,397],[286,397]],"region":{"top_left_x":285,"top_left_y":339,"width":1552,"height":59},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0f5f0fd5b5040ba8416e54e127b09b9","type":"text","conversion_output":true,"text":"mcg/kg/min doses (at discretion of the attending physician) will be started in non-","text_display":" mcg/kg/min doses (at discretion of the attending physician) will be started in non","confidence":0.7479262351989746,"confidence_rate":0.9967048622639079},{"cnt":[[288,434],[1837,434],[1837,492],[288,492]],"region":{"top_left_x":287,"top_left_y":433,"width":1550,"height":59},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c64366c4b2ad4004b242cfc51921d5f6","type":"text","conversion_output":true,"text":"hypertensive patients with persistent abnormal capillary refill time or non-achieved lactate","text_display":"hypertensive patients with persistent abnormal capillary refill time or non-achieved lactate","confidence":1,"confidence_rate":1},{"cnt":[[288,529],[1837,529],[1837,587],[288,587]],"region":{"top_left_x":287,"top_left_y":528,"width":1550,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94976770b4b349e2b72999d91a54020c","type":"text","conversion_output":true,"text":"goals, and negative fluid-responsive status. Similarly, this open-label test of inodilators will","text_display":" goals, and negative fluid-responsive status. Similarly, this open-label test of inodilators will","confidence":1,"confidence_rate":1},{"cnt":[[288,627],[1837,627],[1837,683],[288,683]],"region":{"top_left_x":287,"top_left_y":627,"width":1550,"height":57},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ef7855537fb4e80bb599c306865ae08","type":"text","conversion_output":true,"text":"be performed in hypertensive patients with persistently abnormal resuscitation parameters","text_display":" be performed in hypertensive patients with persistently abnormal resuscitation parameters","confidence":0.9951193332672119,"confidence_rate":0.9999479522472647},{"cnt":[[288,724],[1837,724],[1837,780],[288,780]],"region":{"top_left_x":287,"top_left_y":724,"width":1550,"height":56},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8290fad4d4e64975bdb522f773a4e6f9","type":"text","conversion_output":true,"text":"and a failed vasopressor test. Capillary refill time and lactate goals will be rechecked such as","text_display":" and a failed vasopressor test. Capillary refill time and lactate goals will be rechecked such as","confidence":1,"confidence_rate":1},{"cnt":[[288,819],[1837,819],[1837,874],[288,874]],"region":{"top_left_x":287,"top_left_y":818,"width":1550,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bddaa873dd34463b6e34da4d4313e82","type":"text","conversion_output":true,"text":"in the vasopressor test. If such resuscitation goals are not reached, drugs will be discontinued","text_display":" in the vasopressor test. If such resuscitation goals are not reached, drugs will be discontinued","confidence":1,"confidence_rate":1},{"cnt":[[288,915],[1837,915],[1837,973],[288,973]],"region":{"top_left_x":287,"top_left_y":915,"width":1550,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"faac479b911e4fbbb27eb928bfd63340","type":"text","conversion_output":true,"text":"and no further action will be taken during the study period, except for rechecking fluid","text_display":" and no further action will be taken during the study period, except for rechecking fluid","confidence":1,"confidence_rate":1},{"cnt":[[288,1010],[1837,1010],[1837,1068],[288,1068]],"region":{"top_left_x":287,"top_left_y":1009,"width":1550,"height":59},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f72f8e9e8afc4dba87842958860a05c1","type":"text","conversion_output":true,"text":"responsiveness every hour and restart fluid challenges if the patient gets again fluid","text_display":" responsiveness every hour and restart fluid challenges if the patient gets again fluid","confidence":1,"confidence_rate":1},{"cnt":[[288,1104],[1837,1104],[1837,1162],[288,1162]],"region":{"top_left_x":287,"top_left_y":1104,"width":1550,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f999b2f1e44e2ea3159da7d39ed70f","type":"text","conversion_output":true,"text":"responsive. Dobutamine or milrinone doses will be maintained throughout the study period","text_display":" responsive. Dobutamine or milrinone doses will be maintained throughout the study period","confidence":1,"confidence_rate":1},{"cnt":[[288,1199],[1837,1199],[1837,1259],[288,1259]],"region":{"top_left_x":287,"top_left_y":1198,"width":1550,"height":61},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"457e6a19a84444e38b859cc32f33ecd9","type":"text","conversion_output":true,"text":"in those favorably responding to the open-label inodilators test, i.e., those showing an","text_display":" in those favorably responding to the open-label inodilators test, i.e., those showing an","confidence":0.99755859375,"confidence_rate":0.9999737165675469},{"cnt":[[288,1298],[1837,1298],[1837,1356],[288,1356]],"region":{"top_left_x":287,"top_left_y":1297,"width":1550,"height":59},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37628a1f0dfe4a07a0a8598d83c6b9ef","type":"text","conversion_output":true,"text":"improvement in capillary refill time or lactate goals (according to the group assigned). As a","text_display":" improvement in capillary refill time or lactate goals (according to the group assigned). As a","confidence":1,"confidence_rate":1},{"cnt":[[288,1394],[1833,1394],[1833,1450],[288,1450]],"region":{"top_left_x":287,"top_left_y":1394,"width":1546,"height":57},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d66918256974ea9813ef0177ad08f80","type":"text","conversion_output":true,"text":"safety measure, inodilators will be stopped if heart rate increases \\(>15 \\%\\), or arrhythmias,","text_display":" safety measure, inodilators will be stopped if heart rate increases \\(>15 \\%\\), or arrhythmias,","confidence":1,"confidence_rate":1},{"cnt":[[288,1491],[862,1491],[862,1549],[288,1549]],"region":{"top_left_x":287,"top_left_y":1491,"width":575,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66dfbd32694c4b1c8de156e54ac0dd6c","type":"text","conversion_output":true,"text":"ischemia or hypotension develop.","text_display":" ischemia or hypotension develop.","confidence":1,"confidence_rate":1},{"cnt":[[288,1629],[1837,1629],[1837,1687],[288,1687]],"region":{"top_left_x":287,"top_left_y":1628,"width":1550,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e04390870374a6c8b2f02f93f442b33","type":"text","conversion_output":true,"text":"The protocol can be stopped at any moment for safety considerations during the 8 h -study","text_display":"\n\nThe protocol can be stopped at any moment for safety considerations during the 8 h -study","confidence":0.8491132259368896,"confidence_rate":0.9983492151811791},{"cnt":[[288,1723],[1837,1723],[1837,1781],[288,1781]],"region":{"top_left_x":287,"top_left_y":1723,"width":1550,"height":59},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5624a3559ab1475181c9f8daf25a4cc2","type":"text","conversion_output":true,"text":"period if the attending intensivist considers that the patient has developed unexpected and","text_display":" period if the attending intensivist considers that the patient has developed unexpected and","confidence":1,"confidence_rate":1},{"cnt":[[288,1818],[1794,1818],[1794,1876],[288,1876]],"region":{"top_left_x":287,"top_left_y":1817,"width":1507,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78fdb86a56524d40940ae09dee7e0418","type":"text","conversion_output":true,"text":"severe complications or evolves into refractory shock, conditions that under his judgment","text_display":" severe complications or evolves into refractory shock, conditions that under his judgment","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[288,1916],[943,1916],[943,1974],[288,1974]],"region":{"top_left_x":287,"top_left_y":1916,"width":657,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dd4282f032f4cc592234dfe6d57c739","type":"text","conversion_output":true,"text":"requires liberalization of management.","text_display":" requires liberalization of management.","confidence":1,"confidence_rate":1},{"cnt":[[284,2050],[587,2050],[587,2108],[284,2108]],"region":{"top_left_x":283,"top_left_y":2049,"width":304,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de1cdbac4ca549ccb69e2d40ecf98a75","type":"section_header","conversion_output":false,"children_ids":["db5a8e0551b148b1833d9a41bff344d6"],"text":"","text_display":""},{"cnt":[[288,2055],[580,2052],[580,2101],[288,2104]],"region":{"top_left_x":287,"top_left_y":2052,"width":294,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db5a8e0551b148b1833d9a41bff344d6","type":"text","conversion_output":true,"parent_id":"de1cdbac4ca549ccb69e2d40ecf98a75","text":"SAMPLE SIZE","text_display":"\n\n\\section*{SAMPLE SIZE}","confidence":1,"confidence_rate":1},{"cnt":[[288,2148],[1835,2148],[1835,2206],[288,2206]],"region":{"top_left_x":287,"top_left_y":2148,"width":1548,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a9254fd025c4d45aa5757576ec365f1","type":"text","conversion_output":true,"text":"Mortality in patients with increased lactate levels in circulatory dysfunction has been shown","text_display":"\n\nMortality in patients with increased lactate levels in circulatory dysfunction has been shown","confidence":1,"confidence_rate":1},{"cnt":[[288,2239],[1671,2239],[1671,2301],[288,2301]],"region":{"top_left_x":287,"top_left_y":2238,"width":1385,"height":63},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d2ab19cde254401a6e5c0031de138b1","type":"text","conversion_output":true,"text":"to exceed \\(40 \\% .^{11}\\) In addition, several studies have shown that abnormal peripheral","text_display":" to exceed \\(40 \\% .^{11}\\) In addition, several studies have shown that abnormal peripheral","confidence":0.9103488922119141,"confidence_rate":0.9990220685399221},{"cnt":[[286,2340],[1800,2340],[1800,2396],[286,2396]],"region":{"top_left_x":285,"top_left_y":2339,"width":1516,"height":57},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c14fdda4c18645a5818c7521dc1c64cc","type":"text","conversion_output":true,"text":"perfusion is associated with a mortality exceeding \\(40 \\%\\) as well, whereas a normal CRT in","text_display":" perfusion is associated with a mortality exceeding \\(40 \\%\\) as well, whereas a normal CRT in","confidence":0.9765625,"confidence_rate":0.9997503835107778},{"cnt":[[1805,2582],[1839,2582],[1839,2628],[1805,2628]],"region":{"top_left_x":1804,"top_left_y":2582,"width":36,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c42569749c7453083bc277d1a3f88bd","type":"page_info","conversion_output":false,"text":"8","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-09","page":9,"lines":[{"cnt":[[288,241],[1811,241],[1811,299],[288,299]],"region":{"top_left_x":287,"top_left_y":240,"width":1525,"height":59},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bd8c5ad9f7045779663cb3408bf0c6c","type":"text","conversion_output":true,"text":"the early phase of septic shock has been associated with a less then \\(10 \\%\\) mortality. \\({ }^{12,13}\\) We","text_display":"\nthe early phase of septic shock has been associated with a less then \\(10 \\%\\) mortality. \\({ }^{12,13}\\) We","confidence":0.95458984375,"confidence_rate":0.9995776027463044},{"cnt":[[288,344],[1545,344],[1545,397],[288,397]],"region":{"top_left_x":287,"top_left_y":343,"width":1258,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b62daf38d9b84f4190170bab193134cf","type":"text","conversion_output":true,"text":"anticipate a mortality within 28-days of \\(45 \\%\\) in the LTR group of our trial.","text_display":" anticipate a mortality within 28-days of \\(45 \\%\\) in the LTR group of our trial.","confidence":0.582025993787056,"confidence_rate":0.9935002494619962},{"cnt":[[288,477],[1781,477],[1781,535],[288,535]],"region":{"top_left_x":287,"top_left_y":476,"width":1495,"height":59},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d19247b89f814459be2fd808aa87b155","type":"text","conversion_output":true,"text":"A total sample size of 420 patients ( 210 per group) is expected to provide approximately","text_display":"\n\nA total sample size of 420 patients ( 210 per group) is expected to provide approximately","confidence":0.9980483050458702,"confidence_rate":0.9999804641709025},{"cnt":[[288,571],[1807,571],[1807,629],[288,629]],"region":{"top_left_x":287,"top_left_y":571,"width":1520,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c93aadb4dc047639a908e6d13e8e58f","type":"text","conversion_output":true,"text":"\\(90 \\%\\) power to detect a reduction in 28 -day mortality from \\(45 \\%\\) to \\(30 \\%\\), analyzing the data","text_display":" \\(90 \\%\\) power to detect a reduction in 28 -day mortality from \\(45 \\%\\) to \\(30 \\%\\), analyzing the data","confidence":0.4170796164544299,"confidence_rate":0.9914633308828198},{"cnt":[[288,666],[1708,666],[1708,724],[288,724]],"region":{"top_left_x":287,"top_left_y":666,"width":1422,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a727ba7dd5cf41d5a05f2df695f063f1","type":"text","conversion_output":true,"text":"using the ITT principle, with a two-sided alpha level of \\(5 \\%\\). We consider that a \\(15 \\%\\)","text_display":" using the ITT principle, with a two-sided alpha level of \\(5 \\%\\). We consider that a \\(15 \\%\\)","confidence":1,"confidence_rate":1},{"cnt":[[288,765],[1772,765],[1772,821],[288,821]],"region":{"top_left_x":287,"top_left_y":764,"width":1486,"height":57},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5056d7990664d51bfeac15da31e4335","type":"text","conversion_output":true,"text":"reduction (33\\% relative risk reduction) in mortality has important clinical value and was","text_display":" reduction (33\\% relative risk reduction) in mortality has important clinical value and was","confidence":0.9638671875,"confidence_rate":0.9996085684786136},{"cnt":[[288,855],[1792,855],[1792,917],[288,917]],"region":{"top_left_x":287,"top_left_y":855,"width":1505,"height":63},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"931f37d5897c4450b0124c827bafc105","type":"text","conversion_output":true,"text":"observed in earlier resuscitation studies. \\({ }^{13}\\) In addition, this effect size is plausible because","text_display":" observed in earlier resuscitation studies. \\({ }^{13}\\) In addition, this effect size is plausible because","confidence":1,"confidence_rate":1},{"cnt":[[288,954],[1635,954],[1635,1012],[288,1012]],"region":{"top_left_x":287,"top_left_y":953,"width":1348,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29d68c45733e4eb98988fd794afe00f1","type":"text","conversion_output":true,"text":"limiting fluid administration has been shown to decrease organ failure, the main","text_display":" limiting fluid administration has been shown to decrease organ failure, the main","confidence":1,"confidence_rate":1},{"cnt":[[288,1051],[965,1048],[965,1110],[288,1112]],"region":{"top_left_x":287,"top_left_y":1048,"width":678,"height":64},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7028a8b0dee0468c916b6821f85ede4e","type":"text","conversion_output":true,"text":"determinant of death in septic patients. \\({ }^{8}\\)","text_display":" determinant of death in septic patients. \\({ }^{8}\\)","confidence":1,"confidence_rate":1},{"cnt":[[288,1186],[1717,1186],[1717,1248],[288,1248]],"region":{"top_left_x":287,"top_left_y":1185,"width":1430,"height":64},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b62f833c9f43425db4a522d54b0650fa","type":"text","conversion_output":true,"text":"Nevertheless, we used an adaptive approach, \\({ }^{14}\\) that would allow for a sample-size re-","text_display":"\n\nNevertheless, we used an adaptive approach, \\({ }^{14}\\) that would allow for a sample-size re","confidence":1,"confidence_rate":1},{"cnt":[[288,1285],[1824,1285],[1824,1343],[288,1343]],"region":{"top_left_x":287,"top_left_y":1284,"width":1538,"height":59},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f89901306564d74ae1cf840fb15c373","type":"text","conversion_output":true,"text":"estimation at a preplanned interim analysis after 75\\% of the sample has been recruited. The","text_display":"estimation at a preplanned interim analysis after 75\\% of the sample has been recruited. The","confidence":0.861328125,"confidence_rate":0.998446210990429},{"cnt":[[288,1384],[1732,1384],[1732,1437],[288,1437]],"region":{"top_left_x":287,"top_left_y":1383,"width":1445,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db936df289b449879c8059de999c67e8","type":"text","conversion_output":true,"text":"sample-size re-estimation was supposed to be conducted by the independent Data and","text_display":" sample-size re-estimation was supposed to be conducted by the independent Data and","confidence":1,"confidence_rate":1},{"cnt":[[288,1478],[1721,1478],[1721,1534],[288,1534]],"region":{"top_left_x":287,"top_left_y":1478,"width":1434,"height":56},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74a275eba85c4f87887894feaf3b802d","type":"text","conversion_output":true,"text":"Safety Monitoring Committee (DSMC) only if the size effect observed in the interim","text_display":" Safety Monitoring Committee (DSMC) only if the size effect observed in the interim","confidence":1,"confidence_rate":1},{"cnt":[[288,1573],[1687,1573],[1687,1631],[288,1631]],"region":{"top_left_x":287,"top_left_y":1572,"width":1400,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80bb4d4e65824eb4b573b701a7d2c563","type":"text","conversion_output":true,"text":"analysis is between \\(10 \\%\\) and \\(15 \\%\\) absolute reduction in mortality (promising zone)","text_display":" analysis is between \\(10 \\%\\) and \\(15 \\%\\) absolute reduction in mortality (promising zone)","confidence":0.6988773345947266,"confidence_rate":0.9960705970997437},{"cnt":[[288,1663],[1721,1663],[1721,1725],[288,1725]],"region":{"top_left_x":287,"top_left_y":1662,"width":1434,"height":64},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff52ad33b5e2450b96ed1ced0cc52a12","type":"text","conversion_output":true,"text":"favoring the PPTR over LTR group. \\({ }^{14}\\) The favorable zone was defined as an absolute","text_display":" favoring the PPTR over LTR group. \\({ }^{14}\\) The favorable zone was defined as an absolute","confidence":1,"confidence_rate":1},{"cnt":[[288,1764],[1824,1764],[1824,1820],[288,1820]],"region":{"top_left_x":287,"top_left_y":1763,"width":1538,"height":57},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4093846021464ad888d29476efac0490","type":"text","conversion_output":true,"text":"difference \\(>15 \\%\\) (conditional power \\(>90 \\%\\) ) and unfavorable zone as an absolute difference","text_display":" difference \\(>15 \\%\\) (conditional power \\(>90 \\%\\) ) and unfavorable zone as an absolute difference","confidence":0.9712052345275879,"confidence_rate":0.9997049175965005},{"cnt":[[288,1863],[1242,1863],[1242,1919],[288,1919]],"region":{"top_left_x":287,"top_left_y":1862,"width":955,"height":57},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b30f874b0964ee5abf73dd0b506e446","type":"text","conversion_output":true,"text":"\\(<10 \\%\\) (conditional power \\(<61 \\%\\) ) in the interim analysis.","text_display":" \\(<10 \\%\\) (conditional power \\(<61 \\%\\) ) in the interim analysis.","confidence":0.99755859375,"confidence_rate":0.9999605751103785},{"cnt":[[288,1998],[1777,1998],[1777,2056],[288,2056]],"region":{"top_left_x":287,"top_left_y":1998,"width":1490,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bbd3f259b454a29b2ac328efdee56dc","type":"text","conversion_output":true,"text":"We calculate operational characteristics of this this strategy conducting simulations with","text_display":"\n\nWe calculate operational characteristics of this this strategy conducting simulations with","confidence":0.9985356330871582,"confidence_rate":0.9999845744332286},{"cnt":[[288,2093],[1818,2093],[1818,2151],[288,2151]],"region":{"top_left_x":287,"top_left_y":2092,"width":1531,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dc81d1672c245f7b4bd6ed7147e14c7","type":"text","conversion_output":true,"text":"200 studies. Without adaptation, conditional power for the promising zone is between \\(61 \\%\\)","text_display":" 200 studies. Without adaptation, conditional power for the promising zone is between \\(61 \\%\\)","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[288,2191],[1830,2191],[1830,2245],[288,2245]],"region":{"top_left_x":287,"top_left_y":2191,"width":1544,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3a04d7d851b49b3a58f68da6c4e44cd","type":"text","conversion_output":true,"text":"and \\(90 \\%\\). In case the study interim analysis felt in the promising zone, adapting sample size","text_display":" and \\(90 \\%\\). In case the study interim analysis felt in the promising zone, adapting sample size","confidence":1,"confidence_rate":1},{"cnt":[[288,2286],[1824,2286],[1824,2344],[288,2344]],"region":{"top_left_x":287,"top_left_y":2285,"width":1538,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ab4c25d9f3341a68b3455ab03dba25f","type":"text","conversion_output":true,"text":"up to 840 patients would increase conditional power. Considering a true effect size of \\(15 \\%\\),","text_display":" up to 840 patients would increase conditional power. Considering a true effect size of \\(15 \\%\\),","confidence":0.87744140625,"confidence_rate":0.9987314354123336},{"cnt":[[286,2385],[1747,2385],[1747,2438],[286,2438]],"region":{"top_left_x":285,"top_left_y":2384,"width":1462,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40be865cfc854fd6b8db507825a7330c","type":"text","conversion_output":true,"text":"probability of \"landing\" on promising zone is \\(22 \\%\\) and mean conditional power would","text_display":" probability of \"landing\" on promising zone is \\(22 \\%\\) and mean conditional power would","confidence":0.9931640625,"confidence_rate":0.9999237872426632},{"cnt":[[1800,2582],[1839,2582],[1839,2628],[1800,2628]],"region":{"top_left_x":1800,"top_left_y":2582,"width":40,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46caef726e1546648cfdaf38d3178a75","type":"page_info","conversion_output":false,"text":"9","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-10","page":10,"lines":[{"cnt":[[288,245],[1749,245],[1749,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1462,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7856c97e3bf94342ad94eaaad5a58a6b","type":"text","conversion_output":true,"text":"increase to \\(>90 \\%\\). Considering a true effect size of \\(10 \\%\\), probability of \"falling\" on the","text_display":"\nincrease to \\(>90 \\%\\). Considering a true effect size of \\(10 \\%\\), probability of \"falling\" on the","confidence":0.9936618804931641,"confidence_rate":0.9999370486086219},{"cnt":[[288,344],[1592,344],[1592,397],[288,397]],"region":{"top_left_x":287,"top_left_y":343,"width":1305,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6435c8ddcbd646b2a4c67a0ceef72a8d","type":"text","conversion_output":true,"text":"promising zone is \\(40 \\%\\) and mean conditional power would increase to \\(>80 \\%\\).","text_display":" promising zone is \\(40 \\%\\) and mean conditional power would increase to \\(>80 \\%\\).","confidence":1,"confidence_rate":1},{"cnt":[[288,475],[1796,475],[1796,535],[288,535]],"region":{"top_left_x":287,"top_left_y":474,"width":1510,"height":61},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04f3a38c5d4d4825b38b9e2a5bc8b5ce","type":"text","conversion_output":true,"text":"This interim analysis was performed in February \\(2{ }^{\\text {nd }}\\), 2018, and the DSMC recommended","text_display":"\n\nThis interim analysis was performed in February \\(2{ }^{\\text {nd }}\\), 2018, and the DSMC recommended","confidence":0.9670486450195312,"confidence_rate":0.9996778742041713},{"cnt":[[288,576],[1012,576],[1012,625],[288,625]],"region":{"top_left_x":287,"top_left_y":575,"width":725,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24dd598655ec4af3a9ba5a4c75d72a30","type":"text","conversion_output":true,"text":"to continue the trial with no modifications.","text_display":" to continue the trial with no modifications.","confidence":1,"confidence_rate":1},{"cnt":[[284,709],[595,709],[595,765],[284,765]],"region":{"top_left_x":283,"top_left_y":708,"width":313,"height":57},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b01ca59a0d66484c9edcd4e9dd475665","type":"section_header","conversion_output":false,"children_ids":["968ab4a537984d03976664c5c12a1877"],"text":"","text_display":""},{"cnt":[[288,715],[591,715],[591,758],[288,758]],"region":{"top_left_x":287,"top_left_y":715,"width":304,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"968ab4a537984d03976664c5c12a1877","type":"text","conversion_output":true,"parent_id":"b01ca59a0d66484c9edcd4e9dd475665","text":"FRAMEWORK","text_display":"\n\n\\section*{FRAMEWORK}","confidence":1,"confidence_rate":1},{"cnt":[[288,808],[1798,808],[1798,862],[288,862]],"region":{"top_left_x":287,"top_left_y":807,"width":1512,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d34f79a68f849c0aafc0cb894166291","type":"text","conversion_output":true,"text":"The design of the study is aimed at demonstrating superiority of PPTR over LTR in terms","text_display":"\n\nThe design of the study is aimed at demonstrating superiority of PPTR over LTR in terms","confidence":1,"confidence_rate":1},{"cnt":[[288,902],[1351,902],[1351,956],[288,956]],"region":{"top_left_x":287,"top_left_y":902,"width":1065,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22e8d7d8abd7443ba5277cc9b4258533","type":"text","conversion_output":true,"text":"of 28-day mortality and other secondary and tertiary outcomes.","text_display":" of 28-day mortality and other secondary and tertiary outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[284,1040],[1016,1040],[1016,1094],[284,1094]],"region":{"top_left_x":283,"top_left_y":1039,"width":734,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2cfe0620d6bf4d21bd2328b374a39289","type":"section_header","conversion_output":false,"children_ids":["be7815428e4f46c884d7bc8d8b7f3324"],"text":"","text_display":""},{"cnt":[[288,1044],[1012,1044],[1012,1089],[288,1089]],"region":{"top_left_x":287,"top_left_y":1044,"width":725,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be7815428e4f46c884d7bc8d8b7f3324","type":"text","conversion_output":true,"parent_id":"2cfe0620d6bf4d21bd2328b374a39289","text":"STATISTICAL INTERIM ANALYSES","text_display":"\n\n\\section*{STATISTICAL INTERIM ANALYSES}","confidence":1,"confidence_rate":1},{"cnt":[[288,1139],[1807,1139],[1807,1192],[288,1192]],"region":{"top_left_x":287,"top_left_y":1138,"width":1520,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea07bcd962c041caa54729eadf2eea03","type":"text","conversion_output":true,"text":"Interim analyses were conducted after the inclusion of the first 100 patients and at \\(75 \\%\\) of","text_display":"\n\nInterim analyses were conducted after the inclusion of the first 100 patients and at \\(75 \\%\\) of","confidence":0.9970722198486328,"confidence_rate":0.9999712545848864},{"cnt":[[288,1233],[1820,1233],[1820,1287],[288,1287]],"region":{"top_left_x":287,"top_left_y":1233,"width":1533,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bd0fe7beac04566a99c0668ad853ce8","type":"text","conversion_output":true,"text":"the sample size ( 300 patients). Only the independent data and safety monitoring committee","text_display":" the sample size ( 300 patients). Only the independent data and safety monitoring committee","confidence":0.91845703125,"confidence_rate":0.9991324157847356},{"cnt":[[288,1328],[1824,1328],[1824,1381],[288,1381]],"region":{"top_left_x":287,"top_left_y":1327,"width":1538,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"077b5b966bf042cfb6203c5b222cb0a9","type":"text","conversion_output":true,"text":"(DSMC) had access to results of those analyses. The DSMC is comprised by 5 experienced","text_display":" (DSMC) had access to results of those analyses. The DSMC is comprised by 5 experienced","confidence":1,"confidence_rate":1},{"cnt":[[288,1422],[1710,1422],[1710,1480],[288,1480]],"region":{"top_left_x":287,"top_left_y":1422,"width":1424,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b6dcc07b3364e8caee886461d1d7189","type":"text","conversion_output":true,"text":"intensivists and trialists, and 1 senior statistician. The DSMC established no a priori","text_display":" intensivists and trialists, and 1 senior statistician. The DSMC established no a priori","confidence":1,"confidence_rate":1},{"cnt":[[288,1521],[1639,1521],[1639,1575],[288,1575]],"region":{"top_left_x":287,"top_left_y":1521,"width":1353,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"650eb4564c844970907e948d9447f2ee","type":"text","conversion_output":true,"text":"statistical stopping guidance according to efficacy, safety or futility. The DSMC","text_display":" statistical stopping guidance according to efficacy, safety or futility. The DSMC","confidence":1,"confidence_rate":1},{"cnt":[[288,1616],[1693,1616],[1693,1669],[288,1669]],"region":{"top_left_x":287,"top_left_y":1615,"width":1406,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b77f722978f34993a791096b989114d7","type":"text","conversion_output":true,"text":"recommended that the trial should continue without alterations after those analyses.","text_display":" recommended that the trial should continue without alterations after those analyses.","confidence":1,"confidence_rate":1},{"cnt":[[284,1753],[898,1753],[898,1807],[284,1807]],"region":{"top_left_x":283,"top_left_y":1753,"width":616,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54c9736c0c2748a2b19b3b3addf2aa7d","type":"section_header","conversion_output":false,"children_ids":["3a49b9fa9d674746903e0ffc9834057d"],"text":"","text_display":""},{"cnt":[[288,1757],[892,1757],[892,1803],[288,1803]],"region":{"top_left_x":287,"top_left_y":1757,"width":605,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a49b9fa9d674746903e0ffc9834057d","type":"text","conversion_output":true,"parent_id":"54c9736c0c2748a2b19b3b3addf2aa7d","text":"TIMING OF FINAL ANALYSIS","text_display":"\n\n\\section*{TIMING OF FINAL ANALYSIS}","confidence":1,"confidence_rate":1},{"cnt":[[288,1850],[1811,1850],[1811,1904],[288,1904]],"region":{"top_left_x":287,"top_left_y":1849,"width":1525,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5e8e13dbcbf4e4bb69f85b2c341551c","type":"text","conversion_output":true,"text":"All outcomes will be analyzed simultaneously after we have completed the 90-day follow-","text_display":"\n\nAll outcomes will be analyzed simultaneously after we have completed the 90-day follow","confidence":0.63720703125,"confidence_rate":0.9951134925097183},{"cnt":[[288,1946],[1154,1946],[1154,1998],[288,1998]],"region":{"top_left_x":287,"top_left_y":1946,"width":867,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cd9dbeea4cd48e5814e288282efc320","type":"text","conversion_output":true,"text":"up of all patients and the database has been locked.","text_display":"up of all patients and the database has been locked.","confidence":1,"confidence_rate":1},{"cnt":[[284,2082],[1076,2082],[1076,2136],[284,2136]],"region":{"top_left_x":283,"top_left_y":2081,"width":794,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba0f47e9d96943e2ba235fdeae007766","type":"section_header","conversion_output":false,"children_ids":["843f095bcfcd4605bb07a2c8fd0dad8f"],"text":"","text_display":""},{"cnt":[[288,2088],[1072,2088],[1072,2129],[288,2129]],"region":{"top_left_x":287,"top_left_y":2088,"width":786,"height":42},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"843f095bcfcd4605bb07a2c8fd0dad8f","type":"text","conversion_output":true,"parent_id":"ba0f47e9d96943e2ba235fdeae007766","text":"TIMING OF OUTCOME ASSESSMENTS","text_display":"\n\n\\section*{TIMING OF OUTCOME ASSESSMENTS}","confidence":1,"confidence_rate":1},{"cnt":[[288,2179],[1813,2179],[1813,2232],[288,2232]],"region":{"top_left_x":287,"top_left_y":2178,"width":1527,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b3650b6bbdb477eb1b096081f525cf5","type":"text","conversion_output":true,"text":"We will assess outcomes at 8, 24, 48, and 72 hours; at hospital discharge; and at 28 and 90","text_display":"\n\nWe will assess outcomes at 8, 24, 48, and 72 hours; at hospital discharge; and at 28 and 90","confidence":0.9024381637573242,"confidence_rate":0.9989841291412291},{"cnt":[[288,2277],[389,2277],[389,2327],[288,2327]],"region":{"top_left_x":287,"top_left_y":2277,"width":102,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e96bbcbd9a043089ca927af644910f8","type":"text","conversion_output":true,"text":"days,","text_display":" days,","confidence":1,"confidence_rate":1},{"cnt":[[284,2411],[849,2411],[849,2466],[284,2466]],"region":{"top_left_x":283,"top_left_y":2410,"width":566,"height":57},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74c0eca0fcd74b0c9f05f0308dc1cd30","type":"section_header","conversion_output":false,"children_ids":["7d496e011f4d47dca13db1c71e283251"],"text":"","text_display":""},{"cnt":[[288,2415],[844,2415],[844,2460],[288,2460]],"region":{"top_left_x":287,"top_left_y":2414,"width":558,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d496e011f4d47dca13db1c71e283251","type":"text","conversion_output":true,"parent_id":"74c0eca0fcd74b0c9f05f0308dc1cd30","text":"STATISTICAL PRINCIPLES","text_display":"\n\n\\section*{STATISTICAL PRINCIPLES}","confidence":1,"confidence_rate":1},{"cnt":[[1788,2582],[1839,2582],[1839,2628],[1788,2628]],"region":{"top_left_x":1787,"top_left_y":2582,"width":53,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89cbe470dcf242b4b39cbbae69aa6027","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-11","page":11,"lines":[{"cnt":[[288,245],[907,245],[907,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":620,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5896af1e03f242c191c056e836525c7d","type":"section_header","conversion_output":false,"children_ids":["fb7dc9870cca49e3bd50d8eb3b0df96a"],"text":"","text_display":""},{"cnt":[[292,249],[900,249],[900,294],[292,294]],"region":{"top_left_x":292,"top_left_y":249,"width":609,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb7dc9870cca49e3bd50d8eb3b0df96a","type":"text","conversion_output":true,"parent_id":"5896af1e03f242c191c056e836525c7d","text":"Confidence intervals and \\(P\\) values","text_display":"\n\n\\section*{Confidence intervals and \\(P\\) values}","confidence":0.99951171875,"confidence_rate":0.9999889000502842},{"cnt":[[288,344],[1824,344],[1824,393],[288,393]],"region":{"top_left_x":287,"top_left_y":343,"width":1538,"height":51},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f269f440e984399875db023f0e53e43","type":"text","conversion_output":true,"text":"We will present \\(95 \\%\\) confidence intervals for effect estimates on all primary and secondary","text_display":"\n\nWe will present \\(95 \\%\\) confidence intervals for effect estimates on all primary and secondary","confidence":0.982421875,"confidence_rate":0.9998190525470495},{"cnt":[[288,443],[1747,443],[1747,492],[288,492]],"region":{"top_left_x":287,"top_left_y":442,"width":1460,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1197e636c364827844886c9279255ec","type":"text","conversion_output":true,"text":"outcomes. All hypothesis test will be two-sided with an \\(a\\) of \\(5 \\%\\). We will not adjust P -","text_display":" outcomes. All hypothesis test will be two-sided with an \\(a\\) of \\(5 \\%\\). We will not adjust P ","confidence":0.6630177803970128,"confidence_rate":0.9962021055814131},{"cnt":[[288,541],[1811,541],[1811,591],[288,591]],"region":{"top_left_x":287,"top_left_y":541,"width":1525,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52973dcc426b4a18a7c98d6ab6dadff3","type":"text","conversion_output":true,"text":"values and confidence intervals for analyses of primary or secondary outcomes. Therefore,","text_display":"values and confidence intervals for analyses of primary or secondary outcomes. Therefore,","confidence":1,"confidence_rate":1},{"cnt":[[288,638],[1489,638],[1489,690],[288,690]],"region":{"top_left_x":287,"top_left_y":638,"width":1202,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d23ff1df8ba24a7d8c38e89932137eb9","type":"text","conversion_output":true,"text":"all results for secondary outcomes should be interpreted as exploratory.","text_display":" all results for secondary outcomes should be interpreted as exploratory.","confidence":1,"confidence_rate":1},{"cnt":[[286,773],[926,773],[926,831],[286,831]],"region":{"top_left_x":285,"top_left_y":773,"width":641,"height":59},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d3fe3f10b4a4e9b8dfcd6f6e09080c6","type":"section_header","conversion_output":false,"children_ids":["a4e02b32fc6f4d79b589a2bc3ca04c15"],"text":"","text_display":""},{"cnt":[[288,778],[922,778],[922,827],[288,827]],"region":{"top_left_x":287,"top_left_y":777,"width":635,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4e02b32fc6f4d79b589a2bc3ca04c15","type":"text","conversion_output":true,"parent_id":"6d3fe3f10b4a4e9b8dfcd6f6e09080c6","text":"Adherence and protocol deviations","text_display":"\n\n\\section*{Adherence and protocol deviations}","confidence":1,"confidence_rate":1},{"cnt":[[288,870],[1712,870],[1712,922],[288,922]],"region":{"top_left_x":287,"top_left_y":870,"width":1426,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ba3fcafb6ce4b46a9e3ea7e3b98d70b","type":"text","conversion_output":true,"text":"We will report the numbers and percentages of non-adherence to randomly allocated","text_display":"\n\nWe will report the numbers and percentages of non-adherence to randomly allocated","confidence":1,"confidence_rate":1},{"cnt":[[288,971],[466,971],[466,1012],[288,1012]],"region":{"top_left_x":287,"top_left_y":971,"width":180,"height":41},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe55e71fe50748e3bd9c6303ec641448","type":"text","conversion_output":true,"text":"treatment.","text_display":" treatment.","confidence":1,"confidence_rate":1},{"cnt":[[288,1104],[1818,1104],[1818,1154],[288,1154]],"region":{"top_left_x":287,"top_left_y":1104,"width":1531,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3ef94b2cac24902a366452b688e812f","type":"text","conversion_output":true,"text":"Protocol deviations will be assessed and registered by the local coordinators at each center.","text_display":"\n\nProtocol deviations will be assessed and registered by the local coordinators at each center.","confidence":1,"confidence_rate":1},{"cnt":[[288,1199],[1772,1199],[1772,1250],[288,1250]],"region":{"top_left_x":287,"top_left_y":1198,"width":1486,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7d92721baf94ce187f58241b43c88c5","type":"text","conversion_output":true,"text":"Major deviations are defined as wrong inclusion (misjudgment of inclusion or exclusion","text_display":" Major deviations are defined as wrong inclusion (misjudgment of inclusion or exclusion","confidence":1,"confidence_rate":1},{"cnt":[[288,1298],[1491,1298],[1491,1347],[288,1347]],"region":{"top_left_x":287,"top_left_y":1297,"width":1205,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55733e04eaa44c2287e8376b53dc8522","type":"text","conversion_output":true,"text":"criteria) or inadequate resuscitation procedures during the study period.","text_display":" criteria) or inadequate resuscitation procedures during the study period.","confidence":1,"confidence_rate":1},{"cnt":[[294,1431],[685,1431],[685,1489],[294,1489]],"region":{"top_left_x":294,"top_left_y":1430,"width":392,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83480aa6f7b34440b50c6f6986ca18d3","type":"section_header","conversion_output":false,"children_ids":["29cf1d3df7434156ad884d30c2ae9bcb"],"text":"","text_display":""},{"cnt":[[301,1435],[681,1435],[681,1485],[301,1485]],"region":{"top_left_x":300,"top_left_y":1435,"width":382,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29cf1d3df7434156ad884d30c2ae9bcb","type":"text","conversion_output":true,"parent_id":"83480aa6f7b34440b50c6f6986ca18d3","text":"Analysis populations","text_display":"\n\n\\section*{Analysis populations}","confidence":1,"confidence_rate":1},{"cnt":[[288,1530],[1798,1530],[1798,1583],[288,1583]],"region":{"top_left_x":287,"top_left_y":1529,"width":1512,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfabd19456774fa6b68a4dceb4e91ee0","type":"text","conversion_output":true,"text":"All analyses will be conducted according to the intention-to-treat principle. Thus, patients","text_display":"\n\nAll analyses will be conducted according to the intention-to-treat principle. Thus, patients","confidence":1,"confidence_rate":1},{"cnt":[[288,1624],[1381,1624],[1381,1678],[288,1678]],"region":{"top_left_x":287,"top_left_y":1624,"width":1095,"height":54},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04215b46011240dca57d31e4347117a9","type":"text","conversion_output":true,"text":"will be analyzed in the groups that they were randomly assigned.","text_display":" will be analyzed in the groups that they were randomly assigned.","confidence":1,"confidence_rate":1},{"cnt":[[288,1762],[724,1762],[724,1811],[288,1811]],"region":{"top_left_x":287,"top_left_y":1761,"width":438,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8c2787e214c405fbe6d99add175aaba","type":"section_header","conversion_output":false,"children_ids":["419ebb52d3c8466190f46246a4de47a2"],"text":"","text_display":""},{"cnt":[[288,1766],[720,1766],[720,1807],[288,1807]],"region":{"top_left_x":287,"top_left_y":1766,"width":433,"height":41},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"419ebb52d3c8466190f46246a4de47a2","type":"text","conversion_output":true,"parent_id":"b8c2787e214c405fbe6d99add175aaba","text":"TRIAL POPULATION","text_display":"\n\n\\section*{TRIAL POPULATION}","confidence":1,"confidence_rate":1},{"cnt":[[288,1856],[569,1856],[569,1914],[288,1914]],"region":{"top_left_x":287,"top_left_y":1856,"width":283,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f895e95ad8864d85987b564f115b9a06","type":"section_header","conversion_output":false,"children_ids":["dc30e2e68fc54581a75fc33dc5db4af6"],"text":"","text_display":""},{"cnt":[[288,1861],[565,1861],[565,1910],[288,1910]],"region":{"top_left_x":287,"top_left_y":1860,"width":279,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc30e2e68fc54581a75fc33dc5db4af6","type":"text","conversion_output":true,"parent_id":"f895e95ad8864d85987b564f115b9a06","text":"Screening data","text_display":"\n\n\\section*{Screening data}","confidence":1,"confidence_rate":1},{"cnt":[[288,1955],[1712,1955],[1712,2004],[288,2004]],"region":{"top_left_x":287,"top_left_y":1955,"width":1426,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc689230e3064d40a155d58f065315dd","type":"text","conversion_output":true,"text":"An active daily screening for potentially eligible patients will be performed at all the","text_display":"\n\nAn active daily screening for potentially eligible patients will be performed at all the","confidence":1,"confidence_rate":1},{"cnt":[[288,2050],[1828,2050],[1828,2103],[288,2103]],"region":{"top_left_x":287,"top_left_y":2049,"width":1542,"height":55},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b883012602e4fd1a77b5f531c702e82","type":"text","conversion_output":true,"text":"participating ICUs. Screened patients include all patients admitted to the participating ICUs","text_display":" participating ICUs. Screened patients include all patients admitted to the participating ICUs","confidence":1,"confidence_rate":1},{"cnt":[[288,2140],[1835,2140],[1835,2196],[288,2196]],"region":{"top_left_x":287,"top_left_y":2139,"width":1548,"height":57},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ec75324231e4e9fb0a4d0b0ae682508","type":"text","conversion_output":true,"text":"with septic shock criteria or who develop these criteria during their ICU stay. \\({ }^{10}\\) Patients will","text_display":" with septic shock criteria or who develop these criteria during their ICU stay. \\({ }^{10}\\) Patients will","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[288,2241],[1803,2241],[1803,2292],[288,2292]],"region":{"top_left_x":287,"top_left_y":2240,"width":1516,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98203c11437149c58ad9f68036ba830b","type":"text","conversion_output":true,"text":"be either included or excluded for the study, and the reasons for these latter registered and","text_display":" be either included or excluded for the study, and the reasons for these latter registered and","confidence":1,"confidence_rate":1},{"cnt":[[288,2338],[1051,2338],[1051,2387],[288,2387]],"region":{"top_left_x":287,"top_left_y":2337,"width":764,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdfd9dce73d046b78d3867e0021cfbcc","type":"text","conversion_output":true,"text":"communicated to the SSC on a weekly basis.","text_display":" communicated to the SSC on a weekly basis.","confidence":1,"confidence_rate":1},{"cnt":[[1788,2582],[1835,2582],[1835,2628],[1788,2628]],"region":{"top_left_x":1787,"top_left_y":2582,"width":48,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8d68cedcbb84947a39d0fee1950e078","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-12","page":12,"lines":[{"cnt":[[288,245],[479,245],[479,303],[288,303]],"region":{"top_left_x":287,"top_left_y":244,"width":193,"height":59},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06b1161e956a42ffbfba0d1be6bc19e3","type":"section_header","conversion_output":false,"children_ids":["2c881d81eb4c4404884e7f06c5d23ca3"],"text":"","text_display":""},{"cnt":[[292,249],[475,249],[475,299],[292,299]],"region":{"top_left_x":292,"top_left_y":249,"width":183,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c881d81eb4c4404884e7f06c5d23ca3","type":"text","conversion_output":true,"parent_id":"06b1161e956a42ffbfba0d1be6bc19e3","text":"Eligibility","text_display":"\n\n\\section*{Eligibility}","confidence":1,"confidence_rate":1},{"cnt":[[292,344],[1815,344],[1815,393],[292,393]],"region":{"top_left_x":292,"top_left_y":343,"width":1524,"height":51},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4803e7008a20482d922ffa93716654d6","type":"text","conversion_output":true,"text":"Consecutive adult patients ( \\(\\geq 18\\) years) with septic shock admitted to the intensive care unit","text_display":"\n\nConsecutive adult patients ( \\(\\geq 18\\) years) with septic shock admitted to the intensive care unit","confidence":0.9990236759185791,"confidence_rate":0.9999903287497746},{"cnt":[[290,438],[1757,438],[1757,488],[290,488]],"region":{"top_left_x":290,"top_left_y":438,"width":1468,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a44872392c9048ed8ff3f729400e7700","type":"text","conversion_output":true,"text":"will be considered eligible. Septic shock is defined as suspected or confirmed infection,","text_display":" will be considered eligible. Septic shock is defined as suspected or confirmed infection,","confidence":1,"confidence_rate":1},{"cnt":[[288,535],[1811,535],[1811,587],[288,587]],"region":{"top_left_x":287,"top_left_y":534,"width":1525,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"078e2d20c42e45708e398cf34d216195","type":"text","conversion_output":true,"text":"plus hyperlactatemia ( \\(\\geq 2.0 mmol\\) per liter) and vasopressor requirements due to refractory","text_display":" plus hyperlactatemia ( \\(\\geq 2.0 mmol\\) per liter) and vasopressor requirements due to refractory","confidence":0.9863464774098247,"confidence_rate":0.9998625335580015},{"cnt":[[288,625],[1828,625],[1828,681],[288,681]],"region":{"top_left_x":287,"top_left_y":625,"width":1542,"height":57},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"993482bea71a41ff8e026ab85a718d53","type":"text","conversion_output":true,"text":"hypotension. \\({ }^{10}\\) This latter is characterized as a systolic blood pressure (SBP) \\(<90 mmHg\\) or","text_display":" hypotension. \\({ }^{10}\\) This latter is characterized as a systolic blood pressure (SBP) \\(<90 mmHg\\) or","confidence":0.9208984375,"confidence_rate":0.9992578834060397},{"cnt":[[288,726],[1772,726],[1772,776],[288,776]],"region":{"top_left_x":287,"top_left_y":726,"width":1486,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d020976e8d446f58e876ae7b0e51924","type":"text","conversion_output":true,"text":"a mean arterial pressure (MAP) \\(<65 mmHg\\) after an intravenous fluid load of at least 20","text_display":" a mean arterial pressure (MAP) \\(<65 mmHg\\) after an intravenous fluid load of at least 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of:","confidence":1,"confidence_rate":1},{"cnt":[[352,1109],[608,1109],[608,1149],[352,1149]],"region":{"top_left_x":352,"top_left_y":1108,"width":257,"height":42},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8444d125139944feb6153ff3c361a25e","type":"text","conversion_output":true,"text":"- pregnancy;","text_display":"\n- pregnancy;","confidence":1,"confidence_rate":1},{"cnt":[[352,1195],[1798,1195],[1798,1244],[352,1244]],"region":{"top_left_x":352,"top_left_y":1194,"width":1447,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9fc0739d71d4a749ab5467e760e6bd1","type":"text","conversion_output":true,"text":"- anticipated surgery or dialysis procedure during the first 8 hours after septic shock","text_display":"\n- anticipated surgery or dialysis procedure during the first 8 hours after septic shock","confidence":1,"confidence_rate":1},{"cnt":[[417,1291],[591,1291],[591,1338],[417,1338]],"region":{"top_left_x":416,"top_left_y":1291,"width":175,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40c9da35d0394b16873d9ca90858ab10","type":"text","conversion_output":true,"text":"diagnosis;","text_display":" diagnosis;","confidence":1,"confidence_rate":1},{"cnt":[[352,1388],[1021,1388],[1021,1437],[352,1437]],"region":{"top_left_x":352,"top_left_y":1387,"width":669,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34e3b55ed71142199af8900e655512da","type":"text","conversion_output":true,"text":"- Do-not-attempt-resuscitation status;","text_display":"\n- Do-not-attempt-resuscitation status;","confidence":0.99951171875,"confidence_rate":0.9999886419133848},{"cnt":[[352,1482],[690,1482],[690,1532],[352,1532]],"region":{"top_left_x":352,"top_left_y":1482,"width":338,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bffabe6a8764e0591d49e244262c384","type":"text","conversion_output":true,"text":"- active bleeding;","text_display":"\n- active bleeding;","confidence":1,"confidence_rate":1},{"cnt":[[352,1577],[973,1577],[973,1629],[352,1629]],"region":{"top_left_x":352,"top_left_y":1576,"width":622,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89026839f6d24f66a837f3d9b5445204","type":"text","conversion_output":true,"text":"- acute hematological malignancy;","text_display":"\n- acute hematological malignancy;","confidence":1,"confidence_rate":1},{"cnt":[[352,1676],[1506,1676],[1506,1725],[352,1725]],"region":{"top_left_x":352,"top_left_y":1675,"width":1155,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4149e529eab64cff9183a8465f651807","type":"text","conversion_output":true,"text":"- concomitant severe acute respiratory distress syndrome (ARDS);","text_display":"\n- concomitant severe acute respiratory distress syndrome (ARDS);","confidence":1,"confidence_rate":1},{"cnt":[[352,1770],[1287,1770],[1287,1820],[352,1820]],"region":{"top_left_x":352,"top_left_y":1770,"width":935,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed8320b66ada4ff1895f5fb6fcdac0a1","type":"text","conversion_output":true,"text":"- more than 4 h after the onset of septic shock criteria.","text_display":"\n- more than 4 h after the onset of septic shock criteria.","confidence":0.9882962703704834,"confidence_rate":0.9998243026397252},{"cnt":[[288,1908],[526,1908],[526,1953],[288,1953]],"region":{"top_left_x":287,"top_left_y":1907,"width":240,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ec4f5f6b87d4e93a3cb7a14f1a353f0","type":"section_header","conversion_output":false,"children_ids":["f75a41b10a6c4cc3ba9f80e01b162af1"],"text":"","text_display":""},{"cnt":[[292,1912],[526,1912],[526,1949],[292,1949]],"region":{"top_left_x":292,"top_left_y":1912,"width":235,"height":37},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f75a41b10a6c4cc3ba9f80e01b162af1","type":"text","conversion_output":true,"parent_id":"5ec4f5f6b87d4e93a3cb7a14f1a353f0","text":"Recruitment","text_display":"\n\n\\section*{Recruitment}","confidence":1,"confidence_rate":1},{"cnt":[[292,2007],[1699,2007],[1699,2056],[292,2056]],"region":{"top_left_x":292,"top_left_y":2006,"width":1408,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07fd95974e5740daaae764975fd58496","type":"text","conversion_output":true,"text":"Information that will be included in the CONSORT flow diagram is shown in Fig 2.","text_display":"\n\nInformation that will be included in the CONSORT flow diagram is shown in Fig 2.","confidence":1,"confidence_rate":1},{"cnt":[[288,2140],[698,2140],[698,2194],[288,2194]],"region":{"top_left_x":287,"top_left_y":2139,"width":412,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c8e1d68b5104b9ab3626fd7482e2cc7","type":"section_header","conversion_output":false,"children_ids":["fabf620396b7450a926d7822bf7f3196"],"text":"","text_display":""},{"cnt":[[292,2144],[694,2144],[694,2189],[292,2189]],"region":{"top_left_x":292,"top_left_y":2144,"width":402,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fabf620396b7450a926d7822bf7f3196","type":"text","conversion_output":true,"parent_id":"4c8e1d68b5104b9ab3626fd7482e2cc7","text":"Withdrawal/follow-up","text_display":"\n\n\\section*{Withdrawal/follow-up}","confidence":1,"confidence_rate":1},{"cnt":[[292,2239],[1798,2239],[1798,2288],[292,2288]],"region":{"top_left_x":292,"top_left_y":2238,"width":1507,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b14b3377a0ef401c969b656dcacedf8d","type":"text","conversion_output":true,"text":"We will tabulate the number of patients whose consent for trial participation is withdrawn","text_display":"\n\nWe will tabulate the number of patients whose consent for trial participation is withdrawn","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[292,2333],[1800,2333],[1800,2383],[292,2383]],"region":{"top_left_x":292,"top_left_y":2333,"width":1509,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"993bbf5cc7ef45688bf6b9d7bb8b057d","type":"text","conversion_output":true,"text":"either by the patient or his or her legal representative. When consent is withdrawn for trial","text_display":" either by the patient or his or her legal representative. When consent is withdrawn for trial","confidence":1,"confidence_rate":1},{"cnt":[[1790,2582],[1835,2582],[1835,2628],[1790,2628]],"region":{"top_left_x":1789,"top_left_y":2582,"width":46,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33606db1c21544d5920261c1e141e6d9","type":"page_info","conversion_output":false,"text":"12","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-13","page":13,"lines":[{"cnt":[[288,245],[1772,245],[1772,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1486,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a063c3efb234b03ab67212d672f390f","type":"text","conversion_output":true,"text":"participation we will nevertheless attempt to obtain consent for collecting and analyzing","text_display":"\nparticipation we will nevertheless attempt to obtain consent for collecting and analyzing","confidence":1,"confidence_rate":1},{"cnt":[[288,344],[1171,344],[1171,397],[288,397]],"region":{"top_left_x":287,"top_left_y":343,"width":884,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2de29993519b4843a5bcbfc777e9b6f9","type":"text","conversion_output":true,"text":"follow-up data. These cases should also be reported.","text_display":" follow-up data. These cases should also be reported.","confidence":1,"confidence_rate":1},{"cnt":[[281,475],[862,475],[862,539],[281,539]],"region":{"top_left_x":281,"top_left_y":474,"width":581,"height":66},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74ed05bf6a1c468e9a61b7e4a730abd5","type":"section_header","conversion_output":false,"children_ids":["93d591d3e57440cbbe5af062a89c368d"],"text":"","text_display":""},{"cnt":[[288,481],[855,481],[855,535],[288,535]],"region":{"top_left_x":287,"top_left_y":481,"width":569,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93d591d3e57440cbbe5af062a89c368d","type":"text","conversion_output":true,"parent_id":"74ed05bf6a1c468e9a61b7e4a730abd5","text":"Baseline patient characteristics","text_display":"\n\n\\section*{Baseline patient characteristics}","confidence":1,"confidence_rate":1},{"cnt":[[288,576],[1775,576],[1775,629],[288,629]],"region":{"top_left_x":287,"top_left_y":575,"width":1488,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0007d41744ff4d659f06d39f33f545c7","type":"text","conversion_output":true,"text":"The baseline characteristics to be registered during the trial will be presented as in mock","text_display":"\n\nThe baseline characteristics to be registered during the trial will be presented as in mock","confidence":1,"confidence_rate":1},{"cnt":[[288,670],[423,670],[423,715],[288,715]],"region":{"top_left_x":287,"top_left_y":670,"width":137,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ea6afdc74b144759844cc5a169e3ff3","type":"text","conversion_output":true,"text":"table 1.","text_display":" table 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are:","confidence":1,"confidence_rate":1},{"cnt":[[352,1276],[1016,1276],[1016,1330],[352,1330]],"region":{"top_left_x":352,"top_left_y":1276,"width":665,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ae5a55ed0d741fe8dd828f8873b41c3","type":"text","conversion_output":true,"text":"- All-cause mortality within 90 days;","text_display":"\n- All-cause mortality within 90 days;","confidence":1,"confidence_rate":1},{"cnt":[[352,1371],[1833,1371],[1833,1424],[352,1424]],"region":{"top_left_x":352,"top_left_y":1370,"width":1481,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0af1b01822b340afa02f0185875a89d5","type":"text","conversion_output":true,"text":"- Mechanical ventilation-free days during the first 28 days after randomization. A day","text_display":"\n- Mechanical ventilation-free days during the first 28 days after randomization. A day","confidence":1,"confidence_rate":1},{"cnt":[[412,1467],[1682,1467],[1682,1519],[412,1519]],"region":{"top_left_x":412,"top_left_y":1467,"width":1271,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aed6542d0c004a96b300029a4d2e67a0","type":"text","conversion_output":true,"text":"free of mechanical ventilation is defined as no need of invasive mechanical","text_display":" free of mechanical ventilation is defined as no need of invasive mechanical","confidence":1,"confidence_rate":1},{"cnt":[[412,1564],[1137,1564],[1137,1618],[412,1618]],"region":{"top_left_x":412,"top_left_y":1564,"width":725,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58983a46acb8478c9350a7ced205a38b","type":"text","conversion_output":true,"text":"ventilation in any time during a given day;","text_display":" ventilation in any time during a given day;","confidence":1,"confidence_rate":1},{"cnt":[[350,1661],[1785,1661],[1785,1714],[350,1714]],"region":{"top_left_x":350,"top_left_y":1660,"width":1436,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef2ba27dabe047c4881432bf27619af5","type":"text","conversion_output":true,"text":"- Renal replacement therapy-free days during the first 28 days after randomization;","text_display":"\n- Renal replacement therapy-free days during the first 28 days after randomization;","confidence":1,"confidence_rate":1},{"cnt":[[352,1757],[1545,1757],[1545,1811],[352,1811]],"region":{"top_left_x":352,"top_left_y":1757,"width":1193,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04feb59a03bf4826b13b804f8a3b4bf6","type":"text","conversion_output":true,"text":"- Vasopressor-free days during the first 28 days after randomization;","text_display":"\n- Vasopressor-free days during the first 28 days after randomization;","confidence":1,"confidence_rate":1},{"cnt":[[352,1852],[1732,1852],[1732,1906],[352,1906]],"region":{"top_left_x":352,"top_left_y":1851,"width":1380,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c56e2fa8f16b4c9b86118a2033bfd829","type":"text","conversion_output":true,"text":"- Organ dysfunction assessed with the Sepsis-related Organ Failure Assessment","text_display":"\n- Organ dysfunction assessed with the Sepsis-related Organ Failure Assessment","confidence":1,"confidence_rate":1},{"cnt":[[415,1942],[1233,1942],[1233,2000],[415,2000]],"region":{"top_left_x":414,"top_left_y":1942,"width":820,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfd1fc05dafc4df88e0df9da4bda2634","type":"text","conversion_output":true,"text":"(SOFA) score at 72 hours after randomization; \\({ }^{15}\\)","text_display":" (SOFA) score at 72 hours after randomization; \\({ }^{15}\\)","confidence":0.99951171875,"confidence_rate":0.999992122603638},{"cnt":[[352,2045],[1330,2045],[1330,2099],[352,2099]],"region":{"top_left_x":352,"top_left_y":2045,"width":978,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"850d791151af4641b9de123d50971214","type":"text","conversion_output":true,"text":"- ICU and hospital lengths of stay, truncated at 90 days;","text_display":"\n- ICU and hospital lengths of stay, truncated at 90 days;","confidence":1,"confidence_rate":1},{"cnt":[[288,2183],[941,2183],[941,2237],[288,2237]],"region":{"top_left_x":287,"top_left_y":2182,"width":655,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57d6541709524c6ab10dfe44d5951f15","type":"text","conversion_output":true,"text":"Our tertiary exploratory outcomes are:","text_display":"\n\nOur tertiary exploratory outcomes are:","confidence":1,"confidence_rate":1},{"cnt":[[352,2320],[1721,2320],[1721,2370],[352,2370]],"region":{"top_left_x":352,"top_left_y":2320,"width":1369,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"198e8f23efcf4d8392f2ac4a757d3221","type":"text","conversion_output":true,"text":"- Amount of resuscitation fluids in the first 8 and 24 hours after randomization;","text_display":"\n- Amount of resuscitation fluids in the first 8 and 24 hours after randomization;","confidence":1,"confidence_rate":1},{"cnt":[[352,2419],[1317,2419],[1317,2469],[352,2469]],"region":{"top_left_x":352,"top_left_y":2419,"width":965,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68403415703c4c6f912bd2a451e9dac6","type":"text","conversion_output":true,"text":"- Total fluid balance in the first 8, 24, 48 and 72 hours;","text_display":"\n- Total fluid balance in the first 8, 24, 48 and 72 hours;","confidence":0.9975595474243164,"confidence_rate":0.9999645885207127},{"cnt":[[1788,2582],[1839,2582],[1839,2628],[1788,2628]],"region":{"top_left_x":1787,"top_left_y":2582,"width":53,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb0865bdc56f4dcb838b3d0019b1ff79","type":"page_info","conversion_output":false,"text":"13","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-14","page":14,"lines":[{"cnt":[[352,249],[1777,249],[1777,299],[352,299]],"region":{"top_left_x":352,"top_left_y":249,"width":1425,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07052b66a0f34a1a9b6a1d30bef344e7","type":"text","conversion_output":true,"text":"- Occurrence of intra-abdominal hypertension (IAH) during the first 72 hours after","text_display":"\n- Occurrence of intra-abdominal hypertension (IAH) during the first 72 hours after","confidence":1,"confidence_rate":1},{"cnt":[[417,344],[746,344],[746,393],[417,393]],"region":{"top_left_x":416,"top_left_y":343,"width":330,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f04b1406a37b4f128f60ec7a545944a6","type":"text","conversion_output":true,"text":"randomization (\\%).","text_display":" randomization (\\%).","confidence":1,"confidence_rate":1},{"cnt":[[352,443],[965,443],[965,492],[352,492]],"region":{"top_left_x":352,"top_left_y":442,"width":613,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"421eca24d23d40a5b5362eb974944691","type":"text","conversion_output":true,"text":"- Use of RRT (\\%) within 28 days;","text_display":"\n- Use of RRT (\\%) within 28 days;","confidence":0.99853515625,"confidence_rate":0.9999633527294652},{"cnt":[[352,537],[1132,537],[1132,587],[352,587]],"region":{"top_left_x":352,"top_left_y":537,"width":781,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7976bd7cc4544cfa3c20e7d9901e53d","type":"text","conversion_output":true,"text":"- In-hospital mortality, truncated at 90 days.","text_display":"\n- In-hospital mortality, truncated at 90 days.","confidence":1,"confidence_rate":1},{"cnt":[[292,675],[1669,675],[1669,724],[292,724]],"region":{"top_left_x":292,"top_left_y":674,"width":1378,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df2905fabbce4831bdc87726c8c2c37a","type":"text","conversion_output":true,"text":"The protocol did not call for systematic measurement of intra-abdominal pressure.","text_display":"\n\nThe protocol did not call for systematic measurement of intra-abdominal pressure.","confidence":1,"confidence_rate":1},{"cnt":[[292,769],[1738,769],[1738,819],[292,819]],"region":{"top_left_x":292,"top_left_y":769,"width":1447,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"175fba167e3d4e608058f30140ed9af6","type":"text","conversion_output":true,"text":"Therefore, intra-abdominal pressure was measured according to physicians' discretion","text_display":" Therefore, intra-abdominal pressure was measured according to physicians' discretion","confidence":0.9941432476043701,"confidence_rate":0.9999340025101695},{"cnt":[[290,868],[1201,868],[1201,917],[290,917]],"region":{"top_left_x":290,"top_left_y":867,"width":911,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69dc2b7aee3644fca84fd798407732ed","type":"text","conversion_output":true,"text":"when they suspected of intra-abdominal hypertension.","text_display":" when they suspected of intra-abdominal hypertension.","confidence":1,"confidence_rate":1},{"cnt":[[288,1001],[614,1001],[614,1057],[288,1057]],"region":{"top_left_x":287,"top_left_y":1001,"width":328,"height":57},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d89521a80c746ddace5db53064fa087","type":"section_header","conversion_output":false,"children_ids":["cf3e35a17db44f79bf89348caaa0f8d5"],"text":"","text_display":""},{"cnt":[[292,1005],[608,1005],[608,1051],[292,1051]],"region":{"top_left_x":292,"top_left_y":1005,"width":317,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf3e35a17db44f79bf89348caaa0f8d5","type":"text","conversion_output":true,"parent_id":"3d89521a80c746ddace5db53064fa087","text":"Analysis methods","text_display":"\n\n\\section*{Analysis methods}","confidence":1,"confidence_rate":1},{"cnt":[[292,1096],[1622,1096],[1622,1147],[292,1147]],"region":{"top_left_x":292,"top_left_y":1095,"width":1331,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a186b6668a648548fde978729933625","type":"text","conversion_output":true,"text":"Continuous distribution will be assessed by visual inspection of histograms and","text_display":"\n\nContinuous distribution will be assessed by visual inspection of histograms and","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[292,1195],[1635,1195],[1635,1244],[292,1244]],"region":{"top_left_x":292,"top_left_y":1194,"width":1343,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd0d2213911540649ba994fdb1ead239","type":"text","conversion_output":true,"text":"D'Agostino-Pearson's normality tests. Variables will be expressed as counts and","text_display":" D'Agostino-Pearson's normality tests. Variables will be expressed as counts and","confidence":1,"confidence_rate":1},{"cnt":[[288,1289],[1781,1289],[1781,1338],[288,1338]],"region":{"top_left_x":287,"top_left_y":1289,"width":1495,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82aaeae8337b4b858a2481b3b7da9aa0","type":"text","conversion_output":true,"text":"percentages, mean and standard deviation (SD), or median and interquartile range (IQR),","text_display":" percentages, mean and standard deviation (SD), or median and interquartile range (IQR),","confidence":1,"confidence_rate":1},{"cnt":[[290,1386],[1815,1386],[1815,1435],[290,1435]],"region":{"top_left_x":290,"top_left_y":1385,"width":1526,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8aef236279c848fd94a74ac8db92f96c","type":"text","conversion_output":true,"text":"whenever appropriate, as indicated in mock tables 1 to 3 , which we intend to include in the","text_display":" whenever appropriate, as indicated in mock tables 1 to 3 , which we intend to include in the","confidence":0.5910367965698242,"confidence_rate":0.9949074094716218},{"cnt":[[288,1482],[612,1482],[612,1532],[288,1532]],"region":{"top_left_x":287,"top_left_y":1482,"width":326,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5638240d84e9484ea3b4ecc1bfcd07dd","type":"text","conversion_output":true,"text":"main results paper.","text_display":" main results paper.","confidence":1,"confidence_rate":1},{"cnt":[[292,1620],[1830,1620],[1830,1669],[292,1669]],"region":{"top_left_x":292,"top_left_y":1619,"width":1539,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dc490d49c0b4556b6b46cd297460a93","type":"text","conversion_output":true,"text":"The evolution of hemodynamic and perfusion variables in both groups during the study will","text_display":"\n\nThe evolution of hemodynamic and perfusion variables in both groups during the study will","confidence":1,"confidence_rate":1},{"cnt":[[288,1714],[1738,1714],[1738,1764],[288,1764]],"region":{"top_left_x":287,"top_left_y":1714,"width":1452,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3dbb25b3e23541ecbde5839af93c7779","type":"text","conversion_output":true,"text":"be presented as in mock table 2 . We will carry out linear mixed models for continuous","text_display":" be presented as in mock table 2 . We will carry out linear mixed models for continuous","confidence":0.9658203125,"confidence_rate":0.9996300953042058},{"cnt":[[292,1811],[1603,1811],[1603,1858],[292,1858]],"region":{"top_left_x":292,"top_left_y":1811,"width":1311,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b08baa6f680c4c8a950519ae7d671811","type":"text","conversion_output":true,"text":"variables where Gaussian error distribution applies to account for the repeated","text_display":" variables where Gaussian error distribution applies to account for the repeated","confidence":0.9990234375,"confidence_rate":0.9999883686432659},{"cnt":[[288,1908],[1747,1908],[1747,1957],[288,1957]],"region":{"top_left_x":287,"top_left_y":1907,"width":1460,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0b2a3399dba4d7c80df17ea5458b1a9","type":"text","conversion_output":true,"text":"measurements on the same patient. Binary variables will be tested using logistic mixed","text_display":" measurements on the same patient. Binary variables will be tested using logistic mixed","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[290,2002],[1755,2002],[1755,2052],[290,2052]],"region":{"top_left_x":290,"top_left_y":2002,"width":1466,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e7359f045924d9ab832e54e47cd1570","type":"text","conversion_output":true,"text":"regression models and continuous variables with non-symmetrical distributions such as","text_display":" regression models and continuous variables with non-symmetrical distributions such as","confidence":1,"confidence_rate":1},{"cnt":[[288,2099],[1502,2099],[1502,2151],[288,2151]],"region":{"top_left_x":287,"top_left_y":2099,"width":1215,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fec9bad59f8143afa42af1f2d232c733","type":"text","conversion_output":true,"text":"Lactate and Mottling score will use the distribution that best fit the data.","text_display":" Lactate and Mottling score will use the distribution that best fit the data.","confidence":0.99853515625,"confidence_rate":0.9999819024145966},{"cnt":[[292,2237],[1663,2237],[1663,2288],[292,2288]],"region":{"top_left_x":292,"top_left_y":2236,"width":1371,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ac6bd2971fd4f2b8ec959b50fc628c1","type":"text","conversion_output":true,"text":"We will assess the effect of PPTR versus LTR on the primary outcome using Cox","text_display":"\n\nWe will assess the effect of PPTR versus LTR on the primary outcome using Cox","confidence":1,"confidence_rate":1},{"cnt":[[288,2333],[1717,2333],[1717,2383],[288,2383]],"region":{"top_left_x":287,"top_left_y":2333,"width":1430,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f457c057d2d4aacaab4a858259713ad","type":"text","conversion_output":true,"text":"proportional hazards models, with adjustment for 5 pre-specified baseline covariates:","text_display":" proportional hazards models, with adjustment for 5 pre-specified baseline covariates:","confidence":1,"confidence_rate":1},{"cnt":[[290,2428],[1697,2428],[1697,2477],[290,2477]],"region":{"top_left_x":290,"top_left_y":2427,"width":1408,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3858e79511eb41188ee38fc09101e57d","type":"text","conversion_output":true,"text":"APACHE II score, SOFA score, lactate level, CRT and source of infection, as fixed","text_display":" APACHE II score, SOFA score, lactate level, CRT and source of infection, as fixed","confidence":0.9990236759185791,"confidence_rate":0.9999886419133848},{"cnt":[[1790,2582],[1835,2582],[1835,2628],[1790,2628]],"region":{"top_left_x":1789,"top_left_y":2582,"width":46,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0125afa8fc4e35b06c18671e690b56","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-15","page":15,"lines":[{"cnt":[[288,245],[1768,245],[1768,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1482,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36159b5f00694725b15a85ae303a5cd2","type":"text","conversion_output":true,"text":"(individual-level) effects. Results will be reported as hazard ratios with \\(95 \\%\\) confidence","text_display":"\n(individual-level) effects. Results will be reported as hazard ratios with \\(95 \\%\\) confidence","confidence":0.998046875,"confidence_rate":0.9999798452048033},{"cnt":[[286,339],[1528,339],[1528,397],[286,397]],"region":{"top_left_x":285,"top_left_y":339,"width":1243,"height":59},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7d62d258e9f4aaaa659927a18c996f0","type":"text","conversion_output":true,"text":"intervals (CI) and P-values. We should also present Kaplan Meier curves.","text_display":" intervals (CI) and P-values. We should also present Kaplan Meier curves.","confidence":0.9990234375,"confidence_rate":0.9999873112539076},{"cnt":[[284,475],[1824,475],[1824,535],[284,535]],"region":{"top_left_x":283,"top_left_y":474,"width":1542,"height":61},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba0b926a351342ec9566ac603f2110d3","type":"text","conversion_output":true,"text":"Effects on secondary and tertiary outcomes will be presented as hazard ratio for 90-day all-","text_display":"\n\nEffects on secondary and tertiary outcomes will be presented as hazard ratio for 90-day all","confidence":0.9814453125,"confidence_rate":0.9998069363185084},{"cnt":[[288,571],[1747,571],[1747,629],[288,629]],"region":{"top_left_x":287,"top_left_y":571,"width":1460,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7abbb058ac04edf89c8d5df7a1407fe","type":"text","conversion_output":true,"text":"cause mortality and renal replacement therapy within 28 days, or risk difference for all","text_display":"cause mortality and renal replacement therapy within 28 days, or risk difference for all","confidence":1,"confidence_rate":1},{"cnt":[[286,666],[1760,666],[1760,724],[286,724]],"region":{"top_left_x":285,"top_left_y":666,"width":1475,"height":59},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f039ebdee5174c9e8297eb82b889e2fb","type":"text","conversion_output":true,"text":"other binary outcomes, along with \\(95 \\% CI\\) and P -values (calculated with Fisher's exact","text_display":" other binary outcomes, along with \\(95 \\% CI\\) and P -values (calculated with Fisher's exact","confidence":0.9844433376565576,"confidence_rate":0.9998462967449627},{"cnt":[[288,765],[1796,765],[1796,821],[288,821]],"region":{"top_left_x":287,"top_left_y":764,"width":1510,"height":57},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22319bbd916d48cfb4a998b8efcf8257","type":"text","conversion_output":true,"text":"tests), as shown in mock table 3 . The effect on 90 -day all-cause mortality and the need of","text_display":" tests), as shown in mock table 3 . The effect on 90 -day all-cause mortality and the need of","confidence":0.8208712646737695,"confidence_rate":0.9980854372063525},{"cnt":[[288,859],[1775,859],[1775,917],[288,917]],"region":{"top_left_x":287,"top_left_y":859,"width":1488,"height":59},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ba6fb3222e74a6bb95d2e2a2669ad11","type":"text","conversion_output":true,"text":"renal replacement therapy within 28 days will be assessed with Cox-proportional hazard","text_display":" renal replacement therapy within 28 days will be assessed with Cox-proportional hazard","confidence":1,"confidence_rate":1},{"cnt":[[288,958],[1132,958],[1132,1016],[288,1016]],"region":{"top_left_x":287,"top_left_y":958,"width":846,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34eb978cf96b4da7928176c0d4be42bc","type":"text","conversion_output":true,"text":"model without adjustment for baseline covariates.","text_display":" model without adjustment for baseline covariates.","confidence":1,"confidence_rate":1},{"cnt":[[288,1091],[1826,1091],[1826,1154],[288,1154]],"region":{"top_left_x":287,"top_left_y":1091,"width":1540,"height":63},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e5e11ebd862406aaed1b676de908e96","type":"text","conversion_output":true,"text":"We will estimate the effect on mechanical ventilation-free days, renal replacement therapy-","text_display":"\n\nWe will estimate the effect on mechanical ventilation-free days, renal replacement therapy","confidence":1,"confidence_rate":1},{"cnt":[[288,1190],[1796,1190],[1796,1248],[288,1248]],"region":{"top_left_x":287,"top_left_y":1190,"width":1510,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b237d795fc7a42ba875a06a9a41d332c","type":"text","conversion_output":true,"text":"free days and vasopressors-free days within 28 days with generalized linear models using","text_display":"free days and vasopressors-free days within 28 days with generalized linear models using","confidence":1,"confidence_rate":1},{"cnt":[[288,1285],[1815,1285],[1815,1343],[288,1343]],"region":{"top_left_x":287,"top_left_y":1284,"width":1529,"height":59},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76f6a97710f4427ab0977869fbe41110","type":"text","conversion_output":true,"text":"the distribution that better fits the data (possibly truncated Poisson distribution). Effects on","text_display":" the distribution that better fits the data (possibly truncated Poisson distribution). Effects on","confidence":0.9990234375,"confidence_rate":0.9999903263869102},{"cnt":[[288,1379],[1760,1379],[1760,1439],[288,1439]],"region":{"top_left_x":287,"top_left_y":1379,"width":1473,"height":61},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec5cfde34b924d9a95afab1803223dd8","type":"text","conversion_output":true,"text":"organ dysfunction at 72 hours (measured by SOFA) will be calculated with generalized","text_display":" organ dysfunction at 72 hours (measured by SOFA) will be calculated with generalized","confidence":1,"confidence_rate":1},{"cnt":[[288,1474],[1807,1474],[1807,1536],[288,1536]],"region":{"top_left_x":287,"top_left_y":1473,"width":1520,"height":64},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42bc864e18c84c308cca8cb92faa0a81","type":"text","conversion_output":true,"text":"linear models with the distribution that better fits the data with adjustment for the baseline","text_display":" linear models with the distribution that better fits the data with adjustment for the baseline","confidence":1,"confidence_rate":1},{"cnt":[[288,1573],[1704,1573],[1704,1631],[288,1631]],"region":{"top_left_x":287,"top_left_y":1572,"width":1417,"height":59},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"906996f8656e4677bebaf931b962befe","type":"text","conversion_output":true,"text":"SOFA. Effect on other continuous outcomes, such as ICU or hospital length of stay,","text_display":" SOFA. Effect on other continuous outcomes, such as ICU or hospital length of stay,","confidence":1,"confidence_rate":1},{"cnt":[[288,1669],[1824,1669],[1824,1725],[288,1725]],"region":{"top_left_x":287,"top_left_y":1669,"width":1538,"height":57},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de9ceb4c150a489db1671b8b53d4adb7","type":"text","conversion_output":true,"text":"amount or resuscitation fluids, fluid balance, will also be calculated with generalized linear","text_display":" amount or resuscitation fluids, fluid balance, will also be calculated with generalized linear","confidence":1,"confidence_rate":1},{"cnt":[[288,1764],[1807,1764],[1807,1824],[288,1824]],"region":{"top_left_x":287,"top_left_y":1763,"width":1520,"height":62},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4ae55cedf6244d6bae0268828c7fb21","type":"text","conversion_output":true,"text":"models with the distribution that better fits the data (normal, gamma, inverse Gaussian, or","text_display":" models with the distribution that better fits the data (normal, gamma, inverse Gaussian, or","confidence":1,"confidence_rate":1},{"cnt":[[288,1861],[990,1861],[990,1919],[288,1919]],"region":{"top_left_x":287,"top_left_y":1860,"width":704,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"815f0f41e0544f3f9e19dc2f3772c7c6","type":"text","conversion_output":true,"text":"other), without adjustment for covariates.","text_display":" other), without adjustment for covariates.","confidence":1,"confidence_rate":1},{"cnt":[[284,1996],[642,1996],[642,2060],[284,2060]],"region":{"top_left_x":283,"top_left_y":1995,"width":360,"height":66},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"860626c13b5d405ea2566a8ea4f977fc","type":"section_header","conversion_output":false,"children_ids":["79e0428a79724a8e9045d98ed86f5433"],"text":"","text_display":""},{"cnt":[[288,2002],[638,2002],[638,2056],[288,2056]],"region":{"top_left_x":287,"top_left_y":2002,"width":352,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79e0428a79724a8e9045d98ed86f5433","type":"text","conversion_output":true,"parent_id":"860626c13b5d405ea2566a8ea4f977fc","text":"Subgroup analyses","text_display":"\n\n\\section*{Subgroup analyses}","confidence":1,"confidence_rate":1},{"cnt":[[288,2093],[1721,2093],[1721,2151],[288,2151]],"region":{"top_left_x":287,"top_left_y":2092,"width":1434,"height":59},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3f72c4fd0914b9f93d9219da8fd2a0a","type":"text","conversion_output":true,"text":"We will use Cox proportional hazards adjusted for baseline covariates (same as main","text_display":"\n\nWe will use Cox proportional hazards adjusted for baseline covariates (same as main","confidence":1,"confidence_rate":1},{"cnt":[[288,2189],[1755,2189],[1755,2247],[288,2247]],"region":{"top_left_x":287,"top_left_y":2189,"width":1469,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"847594f37826482ba03a482021dd2917","type":"text","conversion_output":true,"text":"analysis) to assess interactions between treatment effect and the following prespecified","text_display":" analysis) to assess interactions between 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We anticipate that this","text_display":"\nmanagement plan prior to locking the database and starting analyses. We anticipate that this","confidence":1,"confidence_rate":1},{"cnt":[[286,339],[1676,339],[1676,397],[286,397]],"region":{"top_left_x":285,"top_left_y":339,"width":1391,"height":59},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65cf9397a83c4f12aae3b883d1a09e0a","type":"text","conversion_output":true,"text":"document will prevent analysis bias and enhance the utility of the reported results.","text_display":" document will prevent analysis bias and enhance the utility of the reported results.","confidence":1,"confidence_rate":1},{"cnt":[[1788,2582],[1839,2582],[1839,2628],[1788,2628]],"region":{"top_left_x":1787,"top_left_y":2582,"width":53,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e71976f4f05c445684d08f52a54b8227","type":"page_info","conversion_output":false,"text":"17","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-18","page":18,"lines":[{"cnt":[[288,245],[1639,245],[1639,299],[288,299]],"region":{"top_left_x":287,"top_left_y":244,"width":1353,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0825b0af28c4a63b2e1bc52f0a037f5","type":"text","conversion_output":true,"text":"Competing interests The authors declare that they have no competing interests.","text_display":"\n\nCompeting interests The authors declare that they have no competing interests.","confidence":1,"confidence_rate":1},{"cnt":[[288,339],[1723,339],[1723,393],[288,393]],"region":{"top_left_x":287,"top_left_y":339,"width":1437,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2fa8bca131a942289b8dc2205e8c76b7","type":"text","conversion_output":true,"text":"Funding The study is financed in part by an internal grant from the Departamento de","text_display":"\nFunding The study is financed in part by an internal grant from the Departamento de","confidence":1,"confidence_rate":1},{"cnt":[[288,391],[1712,391],[1712,440],[288,440]],"region":{"top_left_x":287,"top_left_y":391,"width":1426,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"941ee3a2be184a799d32e3d784c8baa4","type":"text","conversion_output":true,"text":"Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile.","text_display":" Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile.","confidence":1,"confidence_rate":1},{"cnt":[[288,486],[1751,486],[1751,539],[288,539]],"region":{"top_left_x":287,"top_left_y":485,"width":1464,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c28ab024814483a828806f4de46f124","type":"text","conversion_output":true,"text":"Authors' contributions \\(GH , ABC\\), and JB are guarantors of the entire manuscript; JB ,","text_display":"\n\nAuthors' contributions \\(GH , ABC\\), and JB are guarantors of the entire manuscript; JB ,","confidence":0.9026915263384581,"confidence_rate":0.999069756638141},{"cnt":[[288,535],[1811,535],[1811,587],[288,587]],"region":{"top_left_x":287,"top_left_y":534,"width":1525,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8da7ef8d02ee49f6ba20dc292f653be3","type":"text","conversion_output":true,"text":"JLT, GH, GOT, AD, GF, MC, FJH, ABC, RC, LA, LD designed the study; All the authors","text_display":" JLT, GH, GOT, AD, GF, MC, FJH, ABC, RC, LA, LD designed the study; All the authors","confidence":1,"confidence_rate":1},{"cnt":[[288,580],[1729,580],[1729,634],[288,634]],"region":{"top_left_x":287,"top_left_y":580,"width":1443,"height":54},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d0f0633f1654bf78732987a181e7685","type":"text","conversion_output":true,"text":"will help in the data interpretation and the final manuscript draft. All authors read and","text_display":" will help in the data interpretation and the final manuscript draft. All authors read and","confidence":1,"confidence_rate":1},{"cnt":[[288,632],[819,632],[819,683],[288,683]],"region":{"top_left_x":287,"top_left_y":631,"width":532,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"066e64ee1f3d46de99e9912fa1e1b081","type":"text","conversion_output":true,"text":"approved this final manuscript.","text_display":" approved this final 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Vincent JL, De Backer D. Circulatory shock. N Engl J Med. 2013;369(18):1726-","text_display":"\n1. Vincent JL, De Backer D. Circulatory shock. N Engl J Med. 2013;369(18):1726","confidence":0.998046875,"confidence_rate":0.9999767260466069},{"cnt":[[417,455],[520,455],[520,501],[417,501]],"region":{"top_left_x":416,"top_left_y":455,"width":104,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45c90392f7df48668bd880c4b0ca45a2","type":"text","conversion_output":true,"text":"1734.","text_display":"1734.","confidence":1,"confidence_rate":1},{"cnt":[[288,503],[1824,503],[1824,552],[288,552]],"region":{"top_left_x":287,"top_left_y":502,"width":1538,"height":51},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4858e7b0d46641aea40d65144e1fd3a3","type":"text","conversion_output":true,"text":"2. Bakker J, Gris P, Coffernils M, Kahn RJ, Vincent JL. Serial blood lactate levels can","text_display":"\n2. Bakker J, Gris P, Coffernils M, Kahn RJ, Vincent JL. Serial blood lactate levels can","confidence":1,"confidence_rate":1},{"cnt":[[415,552],[1747,552],[1747,604],[415,604]],"region":{"top_left_x":414,"top_left_y":552,"width":1333,"height":52},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0188e6cbb484e5bb27259c512fbe5f8","type":"text","conversion_output":true,"text":"predict the development of multiple organ failure following septic shock. AmJ","text_display":" predict the development of multiple organ failure following septic shock. AmJ","confidence":0.5919051170349121,"confidence_rate":0.9936251750847875},{"cnt":[[415,597],[892,597],[892,649],[415,649]],"region":{"top_left_x":414,"top_left_y":597,"width":478,"height":52},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1216afd2b3e4cb494c9f15f633d8025","type":"text","conversion_output":true,"text":"Surg. 1996;171(2):221-226.","text_display":" Surg. 1996;171(2):221-226.","confidence":1,"confidence_rate":1},{"cnt":[[288,645],[1826,645],[1826,698],[288,698]],"region":{"top_left_x":287,"top_left_y":644,"width":1540,"height":55},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d21bc0b8e0224dc0a70bd157fa84334f","type":"text","conversion_output":true,"text":"3. Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: International","text_display":"\n3. Rhodes A, Evans LE, Alhazzani W, et al. 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The SOFA (Sepsis-related Organ Failure","confidence":1,"confidence_rate":1},{"cnt":[[417,2037],[1813,2037],[1813,2086],[417,2086]],"region":{"top_left_x":416,"top_left_y":2036,"width":1398,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08b11f7a09d242ff86bad222f8cc249e","type":"text","conversion_output":true,"text":"Assessment) score to describe organ dysfunction/failure. On behalf of the Working","text_display":" Assessment) score to describe organ dysfunction/failure. On behalf of the Working","confidence":1,"confidence_rate":1},{"cnt":[[417,2084],[1721,2084],[1721,2136],[417,2136]],"region":{"top_left_x":416,"top_left_y":2083,"width":1305,"height":53},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb3c501a38c64a61b4ec7d6e5d2946ab","type":"text","conversion_output":true,"text":"Group on Sepsis-Related Problems of the European Society of Intensive Care","text_display":" Group on Sepsis-Related Problems of the European Society of Intensive Care","confidence":1,"confidence_rate":1},{"cnt":[[417,2133],[1300,2133],[1300,2185],[417,2185]],"region":{"top_left_x":416,"top_left_y":2133,"width":884,"height":52},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73bff3bdbcde4efb99ffdd51e0eb1987","type":"text","conversion_output":true,"text":"Medicine. Intensive Care Med. 1996;22(7):707-710.","text_display":" Medicine. Intensive Care Med. 1996;22(7):707-710.","confidence":0.99951171875,"confidence_rate":0.9999909555872323},{"cnt":[[1788,2582],[1839,2582],[1839,2625],[1788,2625]],"region":{"top_left_x":1787,"top_left_y":2582,"width":53,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02813e86459d4c11a24616800881213c","type":"page_info","conversion_output":false,"text":"19","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-20","page":20,"lines":[{"cnt":[[288,245],[737,245],[737,303],[288,303]],"region":{"top_left_x":287,"top_left_y":244,"width":450,"height":59},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1bd3aeabefa42a0a5c455329cf4d4c6","type":"section_header","conversion_output":false,"children_ids":["f7e174f87c22428aaff7c0e870af1fb1"],"text":"","text_display":""},{"cnt":[[288,249],[733,249],[733,299],[288,299]],"region":{"top_left_x":287,"top_left_y":249,"width":446,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7e174f87c22428aaff7c0e870af1fb1","type":"text","conversion_output":true,"parent_id":"c1bd3aeabefa42a0a5c455329cf4d4c6","text":"FIGURE LEGENDS","text_display":"\n\n\\section*{FIGURE LEGENDS}","confidence":1,"confidence_rate":1},{"cnt":[[288,346],[1704,346],[1704,406],[288,406]],"region":{"top_left_x":287,"top_left_y":345,"width":1417,"height":62},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7668b06cde7642ae882ea680b958aef9","type":"text","conversion_output":true,"text":"Figure 1. Sequential approach to resuscitation. The process starts with fluid","text_display":"\n\nFigure 1. Sequential approach to resuscitation. The process starts with fluid","confidence":1,"confidence_rate":1},{"cnt":[[288,421],[1803,421],[1803,477],[288,477]],"region":{"top_left_x":287,"top_left_y":421,"width":1516,"height":56},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c3901bc7913463faa2ae204f68d81e5","type":"text","conversion_output":true,"text":"loading according to the status of fluid-responsiveness. If the goal is not obtained,","text_display":" loading according to the status of fluid-responsiveness. If the goal is not obtained,","confidence":1,"confidence_rate":1},{"cnt":[[288,494],[1504,494],[1504,548],[288,548]],"region":{"top_left_x":287,"top_left_y":494,"width":1217,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0937e7bada042ad93257cf1a411d779","type":"text","conversion_output":true,"text":"the second step is a vasopressor test, and then an inodilator test.","text_display":" the second step is a vasopressor test, and then an inodilator test.","confidence":1,"confidence_rate":1},{"cnt":[[288,563],[1308,563],[1308,621],[288,621]],"region":{"top_left_x":287,"top_left_y":562,"width":1022,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2696f5cafb1409d924d49376eda4f86","type":"text","conversion_output":true,"text":"CRT, capillary refill time; MAP, mean arterial pressure.","text_display":" CRT, capillary refill time; MAP, mean arterial pressure.","confidence":1,"confidence_rate":1},{"cnt":[[288,705],[1439,705],[1439,761],[288,761]],"region":{"top_left_x":287,"top_left_y":704,"width":1153,"height":57},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe76823034f1497d99cbc18d1372a275","type":"text","conversion_output":true,"text":"Figure 2. Flow of patients in the ANDROMEDA-SHOCK trial.","text_display":"\n\nFigure 2. Flow of patients in the ANDROMEDA-SHOCK trial.","confidence":1,"confidence_rate":1},{"cnt":[[1783,2582],[1839,2582],[1839,2628],[1783,2628]],"region":{"top_left_x":1783,"top_left_y":2582,"width":57,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad5b7ea758464a3d81ed9d49b207fd7d","type":"page_info","conversion_output":false,"text":"20","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"890479f3-1b65-478a-b1a2-521c2e375f51-21","page":21,"lines":[{"cnt":[[288,245],[1149,245],[1149,294],[288,294]],"region":{"top_left_x":287,"top_left_y":244,"width":863,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db45eed43e924fb7979a4feae9f7b2a1","type":"figure_label","conversion_output":false,"text":"Table 1. Baseline Characteristics of the 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Characteristic & Peripheral perfusion-targeted resuscitation \\(( n = x x x )\\) & Lactate-targeted resuscitation ( \\(n = x x x\\) ) \\\\\n\\hline Age, mean (SD), y & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Women, no.(n\\%) & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Charlson Comorbidity Score, median (IQR) & xx (xx to xx) & xx (xx to xx) \\\\\n\\hline APACHE-II, mean (SD) & xx (xx to xx) & xx (xx to xx) \\\\\n\\hline SOFA, mean (SD) & xx (xx to xx) & xx (xx to xx) \\\\\n\\hline \\multicolumn{3}{|l|}{Septic shock source, no.(n\\%)} \\\\\n\\hline Pneumonia & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Urinary tract infection & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Intraabdominal infection & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Skin or soft-tissue infection & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Other source & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Infection of unknown source & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline \\multicolumn{3}{|l|}{Hemodynamic and perfusion-related variables} \\\\\n\\hline Heart rate, mean (SD), bpm & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Mean arterial pressure, mean (SD), mmHg & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Norepinephrine dose, mean (SD), mcg/kg/min & x.xx (x.xx) & x.xx (x.xx) \\\\\n\\hline Central venous pressure, mean (SD), mmHg & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Serum lactate, mean (SD), mmol/L & x.xx (x.xx) & x.xx (x.xx) \\\\\n\\hline Central venous oxygen saturation, mean (SD), \\% & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Venous-arterial pCO2 gradient, mean (SD), mmHg & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Capillary refilling time, median (IQR), sec & \\(x ( x\\) to x \\()\\) & \\(x ( x\\) to x \\()\\) \\\\\n\\hline Mottling score, median (IQR) & \\(x ( x\\) to x \\()\\) & \\(x ( x\\) to x \\()\\) \\\\\n\\hline \\multicolumn{3}{|l|}{Initial management data} \\\\\n\\hline Time from matching entry criteria to randomization, mean (SD), min. & xx (xx) & xx (xx) \\\\\n\\hline Intravenous fluid loading before randomization, mean SD), mL & xxxx (xxxx) & xxxx (xxxx) \\\\\n\\hline Time from diagnosis of septic shock to first antibiotics, mean (SD), min. & xxx (xxx) & xxx (xxx) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 1. Baseline Characteristics of the Patients}\n\\begin{tabular}{|l|l|l|}\n\\hline Characteristic & Peripheral perfusion-targeted resuscitation \\(( n = x x x )\\) & Lactate-targeted resuscitation ( \\(n = x x x\\) ) \\\\\n\\hline Age, mean (SD), y & xx.x (xx.x) & xx.x (xx.x) \\\\\n\\hline Women, no.(n\\%) & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Charlson Comorbidity Score, median (IQR) & xx (xx to xx) & xx (xx to xx) \\\\\n\\hline APACHE-II, mean (SD) & xx (xx to xx) & xx (xx to xx) \\\\\n\\hline SOFA, mean (SD) & xx (xx to xx) & xx (xx to xx) \\\\\n\\hline \\multicolumn{3}{|l|}{Septic shock source, no.(n\\%)} \\\\\n\\hline Pneumonia & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Urinary tract infection & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Intraabdominal infection & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Skin or soft-tissue infection & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Other source & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline Infection of unknown source & xxx (xx.x) & xxx (xx.x) \\\\\n\\hline 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Variable & Group & Basal & 2h & 4h & 8h & 24h & 48h & 72h \\\\\n\\hline \\multirow[t]{2}{*}{Number of patients} & PPTR & xxx & xxx & xxx & xxx & xxx & xxx & xxx \\\\\n\\hline & LTR & xxx & xxx & xxx & xxx & xxx & xxx & xxx \\\\\n\\hline \\multirow[t]{3}{*}{Heart rate, mean, bpm} & PPTR & xxx & xxx & xxx & xxx & xxx & xxx & xxx \\\\\n\\hline & LTR & xxx & xxx & xxx & xxx & xxx & xxx & xxx \\\\\n\\hline & P-value & - & X.XX & X.XX & X.XX & X.XX & X.XX & X.XX \\\\\n\\hline \\multirow[t]{4}{*}{Systolic blood pressure, mean, mmHg} & PPTR & xxx & xxx & xxx & xxx & xxx & xxx & xxx \\\\\n\\hline & LTR & xxx & xxx & xxx & xxx & xxx & xxx & xxx \\\\\n\\hline & P-value & - & X.XX & X.XX & X.XX & X.XX & X.XX & X.XX \\\\\n\\hline & PPTR & xx & xx & xx & xx & xx & xx & xx \\\\\n\\hline \\multirow[t]{3}{*}{Dyastolic blood pressure, mean, mmHg} & LTR & xx & xx & xx & xx & xx & xx & xx \\\\\n\\hline & P-value & - & X.XX & X.XX & X.XX & X.XX & X.XX & X.XX \\\\\n\\hline & PPTR & xx & xx & xx & xx & xx & 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Outcome & Peripheral perfusion-targeted resuscitation ( \\(n = x x x\\) ) & Lactatetargeted resuscitation ( \\(n = x x x\\) ) & Type of effect estimate & Effect estimate (95\\% CI) & P Value \\\\\n\\hline \\multicolumn{6}{|l|}{Primary Outcome} \\\\\n\\hline Death within 28 days, no. (n\\%) & xx (xx.x) & xx (xx.x) & Hazard ratio & X.XX (X.XX to X.XX) & x.xx \\\\\n\\hline \\multicolumn{6}{|l|}{Secondary Outcomes} \\\\\n\\hline Death within 90 days, no. (n\\%) & xx (xx.x) & xx (xx.x) & Hazard ratio & X.xx (x.xx to x.xx) & X.XX \\\\\n\\hline Mechanical ventilation-free days within 28 days, mean (SD) & xx.x & XX.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline Renal replacement therapy-free days within 28 days, mean (SD) & xx.x & xx.x & Mean difference & x.x (x.x) & X.XX \\\\\n\\hline Vasopressor-free days within 28 days, mean (SD) & xx.x & XX.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline \\multicolumn{6}{|l|}{SOFA, mean (SD)} \\\\\n\\hline SOFA at 8 h & x.x & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline SOFA at 24 h & X.X & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline SOFA at 48 h & x.x & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline SOFA at 72 h & X.X & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline ICU length of stay, mean (SD), d & X.X & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline Hospital length of stay, mean (SD), d & x.x & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline \\multicolumn{6}{|l|}{Tertiary Outcomes} \\\\\n\\hline \\multicolumn{6}{|l|}{Amount Resuscitation fluids, mean (SD), mL} \\\\\n\\hline At 8 h & xxxx (xxxx) & xxxx (xxxx) & Mean difference & xxx (xxx to xxx) & x.xx \\\\\n\\hline At 24 h & xxxx (xxxx) & xxxx (xxxx) & Mean difference & xxx (xxx to xxx) & x.xx \\\\\n\\hline \\multicolumn{6}{|l|}{Total fluid balance, mean (SD), mL} \\\\\n\\hline At 8 h & xxxx (xxxx) & xxxx (xxxx) & Mean difference & xxx (xxx to xxx) & x.xx \\\\\n\\hline At 24 h & xxxx (xxxx) & xxxx (xxxx) & Mean difference & xxx (xxx to xxx) & x.xx \\\\\n\\hline At 72 h & xxxx (xxxx) & xxxx (xxxx) & Mean difference & xxx (xxx to xxx) & x.xx \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3. Outcomes of Patients Treated with Peripheral Perfusion-Targeted Resuscitation versus Lactate-Targeted Resuscitation}\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline Outcome & Peripheral perfusion-targeted resuscitation ( \\(n = x x x\\) ) & Lactatetargeted resuscitation ( \\(n = x x x\\) ) & Type of effect estimate & Effect estimate (95\\% CI) & P Value \\\\\n\\hline \\multicolumn{6}{|l|}{Primary Outcome} \\\\\n\\hline Death within 28 days, no. (n\\%) & xx (xx.x) & xx (xx.x) & Hazard ratio & X.XX (X.XX to X.XX) & x.xx \\\\\n\\hline \\multicolumn{6}{|l|}{Secondary Outcomes} \\\\\n\\hline Death within 90 days, no. (n\\%) & xx (xx.x) & xx (xx.x) & Hazard ratio & X.xx (x.xx to x.xx) & X.XX \\\\\n\\hline Mechanical ventilation-free days within 28 days, mean (SD) & xx.x & XX.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline Renal replacement therapy-free days within 28 days, mean (SD) & xx.x & xx.x & Mean difference & x.x (x.x) & X.XX \\\\\n\\hline Vasopressor-free days within 28 days, mean (SD) & xx.x & XX.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline \\multicolumn{6}{|l|}{SOFA, mean (SD)} \\\\\n\\hline SOFA at 8 h & x.x & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline SOFA at 24 h & X.X & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline SOFA at 48 h & x.x & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline SOFA at 72 h & X.X & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline ICU length of stay, mean (SD), d & X.X & X.X & Mean difference & x.x (x.x) & x.xx \\\\\n\\hline Hospital length of stay, mean (SD), d & x.x & X.X & Mean difference & x.x (x.x) & x.xx 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