diff --git "a/documents/10.1001_jama.2018.8496/sap.lines.json" "b/documents/10.1001_jama.2018.8496/sap.lines.json"
new file mode 100644--- /dev/null
+++ "b/documents/10.1001_jama.2018.8496/sap.lines.json"
@@ -0,0 +1 @@
+{"pages":[{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-01","page":1,"lines":[{"cnt":[[301,370],[733,370],[733,415],[301,415]],"region":{"top_left_x":300,"top_left_y":369,"width":433,"height":46},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b805f1b3cfce45b6b7344831926dcf49","type":"text","conversion_output":true,"text":"Document Type: SAP","text_display":"Document Type: SAP","confidence":1,"confidence_rate":1},{"cnt":[[370,494],[1837,494],[1837,541],[370,541]],"region":{"top_left_x":369,"top_left_y":494,"width":1468,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4454276d80d846c1a1895a6ad40dbdef","type":"text","conversion_output":true,"text":"Official Title: A Phase IIIB, Double-Blind, Multicenter Study to Evaluate the Efficacy","text_display":"\n\nOfficial Title: A Phase IIIB, Double-Blind, Multicenter Study to Evaluate the Efficacy","confidence":0.9990236759185791,"confidence_rate":0.9999892659807285},{"cnt":[[649,541],[1676,541],[1676,587],[649,587]],"region":{"top_left_x":648,"top_left_y":541,"width":1028,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef2670cef20a4f8998b156f0c3d5a10c","type":"text","conversion_output":true,"text":"and Safety of Alteplase in Patients With Mild Stroke: Rapidly","text_display":" and Safety of Alteplase in Patients With Mild Stroke: Rapidly","confidence":1,"confidence_rate":1},{"cnt":[[649,584],[1708,584],[1708,629],[649,629]],"region":{"top_left_x":648,"top_left_y":584,"width":1061,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bf95781a2ec485ca692b6a5e32df7ea","type":"text","conversion_output":true,"text":"Improving Symptoms and Minor Neurologic Deficits (PRISMS)","text_display":" Improving Symptoms and Minor Neurologic Deficits (PRISMS)","confidence":1,"confidence_rate":1},{"cnt":[[352,711],[904,711],[904,750],[352,750]],"region":{"top_left_x":352,"top_left_y":711,"width":553,"height":39},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af1b111753ea4ce29ef460c991f91416","type":"text","conversion_output":true,"text":"NCT Number: NCT02072226","text_display":"\n\nNCT Number: NCT02072226","confidence":1,"confidence_rate":1},{"cnt":[[262,838],[973,838],[973,883],[262,883]],"region":{"top_left_x":262,"top_left_y":837,"width":712,"height":47},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dffbf3324c79466daa5866892dbc46a5","type":"text","conversion_output":true,"text":"Document Date(s): SAP: 17 May 2017","text_display":"\n\nDocument Date(s): SAP: 17 May 2017","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-02","page":2,"lines":[{"cnt":[[825,453],[1351,453],[1351,494],[825,494]],"region":{"top_left_x":825,"top_left_y":453,"width":527,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0e18069d2d84816a7ddb0b6983c966d","type":"section_header","conversion_output":false,"children_ids":["71a60000ff6248dcac434269a900a0e5"],"text":"","text_display":""},{"cnt":[[829,455],[1347,455],[1347,492],[829,492]],"region":{"top_left_x":829,"top_left_y":455,"width":519,"height":37},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71a60000ff6248dcac434269a900a0e5","type":"text","conversion_output":true,"parent_id":"f0e18069d2d84816a7ddb0b6983c966d","text":"STATISTICAL ANALYSIS PLAN","text_display":"\n\n\\section*{STATISTICAL ANALYSIS PLAN}","confidence":1,"confidence_rate":1},{"cnt":[[438,589],[1693,589],[1693,1474],[438,1474]],"region":{"top_left_x":438,"top_left_y":588,"width":1255,"height":886},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa9ff808a0264882b6c62bea347766b5","type":"table","conversion_output":true,"children_ids":["c3ef7a8968c24e059af5ab9001c88443","a3626183ac7a4cdfadad192cfc3dbdeb","ef78ec4fab1746f98e6980d9245b9765","aea08857addc4bb3a4a90478ab493e62","833d0bff241d4947bcf104e5511af2e3","6045f3801a8e47378ff4826a410e5bb4","78952ba27c474bbbbc324b5f33d39e3a","0ba22840a401477794e226b3d294a133","3ef5cdc2e1984289af41d79e62107558","671aa8d3990047eb8a36bbfa4ad2b1f5","23b774b204fa42eabfc23d744337aa05","a28360fe38e64bf7b8e4aa327056b87f","07254e1763174b75b33e143d6990f63b","24d6fc68ac074a4bb93d4e3083a37efd","00d7680342de473ab3ddd4ba04d03651","6831cfe6b1124ebfa5d2a11281aca7cf","a638a4ecc21c4e13bab7122d6a1a9b61","2780f0afa35744faad3b6f368cc599c5","a464c4254244424ab20935b2b72605f2","b47a39a5d55d4752a66c225139619bb0","841650b7e2864f4db7c39d34fb2fce2c","3972050fca984a7eb48224e2856701e4","4bab846ce5ad4d66abc1b83428aa53e9","e3ebaed918974171878c6918de0e8278","067755ea652b4398ac49d56d07c734d1","a10a8b4fbd7a422aa5dc3a64b1d8207f"],"text":"\\begin{tabular}{|l|l|}\n\\hline DATE DRAFT: & 16 May 2017 \\\\\n\\hline IND NUMBER: & 3811 \\\\\n\\hline PLAN PREPARED BY: & ![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-02.jpg?height=101\\&width=483\\&top_left_y=750\\&top_left_x=910) \\\\\n\\hline PROTOCOL NUMBER: & ML29093 / NCT02072226 \\\\\n\\hline SPONSOR: & Genentech, Inc. \\\\\n\\hline STUDY DRUG: & Alteplase (RO5532960) \\\\\n\\hline TITLE: & A PHASE IIIB, DOUBLE-BLIND, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILD STROKE (RAPIDLY IMPROVING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS) \\\\\n\\hline VERSION: & 1.0 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline DATE DRAFT: & 16 May 2017 \\\\\n\\hline IND NUMBER: & 3811 \\\\\n\\hline PLAN PREPARED BY: & ![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-02.jpg?height=101\\&width=483\\&top_left_y=750\\&top_left_x=910) \\\\\n\\hline PROTOCOL NUMBER: & ML29093 / NCT02072226 \\\\\n\\hline SPONSOR: & Genentech, Inc. \\\\\n\\hline STUDY DRUG: & Alteplase (RO5532960) \\\\\n\\hline TITLE: & A PHASE IIIB, DOUBLE-BLIND, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILD STROKE (RAPIDLY IMPROVING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS) \\\\\n\\hline VERSION: & 1.0 \\\\\n\\hline\n\\end{tabular}","confidence":0,"confidence_rate":0},{"cnt":[[438,588],[821,588],[821,1474],[438,1474]],"region":{"top_left_x":438,"top_left_y":588,"width":384,"height":886},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3ef7a8968c24e059af5ab9001c88443","type":"table_column","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[908,588],[1692,588],[1692,1474],[908,1474]],"region":{"top_left_x":907,"top_left_y":588,"width":785,"height":886},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3626183ac7a4cdfadad192cfc3dbdeb","type":"table_column","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,588],[1692,588],[1692,636],[438,636]],"region":{"top_left_x":438,"top_left_y":588,"width":1254,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef78ec4fab1746f98e6980d9245b9765","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,670],[1692,670],[1692,711],[438,711]],"region":{"top_left_x":438,"top_left_y":670,"width":1254,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aea08857addc4bb3a4a90478ab493e62","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,746],[1692,746],[1692,852],[438,852]],"region":{"top_left_x":438,"top_left_y":746,"width":1254,"height":107},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"833d0bff241d4947bcf104e5511af2e3","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,874],[1692,874],[1692,924],[438,924]],"region":{"top_left_x":438,"top_left_y":873,"width":1254,"height":51},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6045f3801a8e47378ff4826a410e5bb4","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,956],[1692,956],[1692,1006],[438,1006]],"region":{"top_left_x":438,"top_left_y":956,"width":1254,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78952ba27c474bbbbc324b5f33d39e3a","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,1038],[1692,1038],[1692,1088],[438,1088]],"region":{"top_left_x":438,"top_left_y":1038,"width":1254,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ba22840a401477794e226b3d294a133","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,1116],[1694,1116],[1694,1404],[438,1404]],"region":{"top_left_x":438,"top_left_y":1116,"width":1256,"height":289},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ef5cdc2e1984289af41d79e62107558","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[438,1433],[1694,1433],[1694,1474],[438,1474]],"region":{"top_left_x":438,"top_left_y":1432,"width":1256,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"671aa8d3990047eb8a36bbfa4ad2b1f5","type":"table_row","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"","text_display":""},{"cnt":[[444,592],[683,592],[683,629],[444,629]],"region":{"top_left_x":444,"top_left_y":592,"width":239,"height":38},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23b774b204fa42eabfc23d744337aa05","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"DATE DRAFT:","text_display":"DATE DRAFT:","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[914,592],[1120,592],[1120,633],[914,633]],"region":{"top_left_x":914,"top_left_y":592,"width":207,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a28360fe38e64bf7b8e4aa327056b87f","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"16 May 2017","text_display":"16 May 2017","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[442,675],[683,675],[683,711],[442,711]],"region":{"top_left_x":442,"top_left_y":674,"width":241,"height":38},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07254e1763174b75b33e143d6990f63b","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"IND NUMBER:","text_display":"IND NUMBER:","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[912,675],[995,675],[995,711],[912,711]],"region":{"top_left_x":912,"top_left_y":674,"width":83,"height":38},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24d6fc68ac074a4bb93d4e3083a37efd","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"3811","text_display":"3811","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[442,753],[815,753],[815,792],[442,792]],"region":{"top_left_x":442,"top_left_y":752,"width":373,"height":40},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00d7680342de473ab3ddd4ba04d03651","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"PLAN PREPARED BY:","text_display":"PLAN PREPARED BY:","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[908,748],[1395,748],[1395,850],[908,850]],"region":{"top_left_x":907,"top_left_y":748,"width":489,"height":103},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6831cfe6b1124ebfa5d2a11281aca7cf","type":"complex_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","children_ids":["8bc1fba9122c4b9192162ec794aff75d"],"text":"![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-02.jpg?height=101\\&width=483\\&top_left_y=750\\&top_left_x=910)","text_display":"![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-02.jpg?height=101\\&width=483\\&top_left_y=750\\&top_left_x=910)","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0,"confidence_rate":0},{"cnt":[[910,750],[1393,750],[1393,850],[910,850]],"region":{"top_left_x":910,"top_left_y":750,"width":483,"height":101},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bc1fba9122c4b9192162ec794aff75d","type":"diagram","conversion_output":false,"parent_id":"6831cfe6b1124ebfa5d2a11281aca7cf","text":"","text_display":"![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-02.jpg?height=101\\&width=483\\&top_left_y=750\\&top_left_x=910)"},{"cnt":[[444,883],[817,883],[817,919],[444,919]],"region":{"top_left_x":444,"top_left_y":882,"width":373,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a638a4ecc21c4e13bab7122d6a1a9b61","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"PROTOCOL NUMBER:","text_display":"PROTOCOL NUMBER:","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[910,878],[1319,878],[1319,919],[910,919]],"region":{"top_left_x":910,"top_left_y":878,"width":410,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2780f0afa35744faad3b6f368cc599c5","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"ML29093 / NCT02072226","text_display":"ML29093 / NCT02072226","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[442,960],[633,960],[633,997],[442,997]],"region":{"top_left_x":442,"top_left_y":960,"width":191,"height":38},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a464c4254244424ab20935b2b72605f2","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"SPONSOR:","text_display":"SPONSOR:","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[910,960],[1163,960],[1163,1002],[910,1002]],"region":{"top_left_x":910,"top_left_y":960,"width":254,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b47a39a5d55d4752a66c225139619bb0","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"Genentech, Inc.","text_display":"Genentech, Inc.","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999755802732609},{"cnt":[[442,1043],[689,1043],[689,1080],[442,1080]],"region":{"top_left_x":442,"top_left_y":1042,"width":248,"height":38},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"841650b7e2864f4db7c39d34fb2fce2c","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"STUDY DRUG:","text_display":"STUDY DRUG:","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[910,1043],[1283,1043],[1283,1084],[910,1084]],"region":{"top_left_x":910,"top_left_y":1042,"width":373,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3972050fca984a7eb48224e2856701e4","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"Alteplase (RO5532960)","text_display":"Alteplase (RO5532960)","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[442,1125],[557,1125],[557,1162],[442,1162]],"region":{"top_left_x":442,"top_left_y":1125,"width":116,"height":37},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bab846ce5ad4d66abc1b83428aa53e9","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"TITLE:","text_display":"TITLE:","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[906,1121],[1692,1121],[1692,1402],[906,1402]],"region":{"top_left_x":905,"top_left_y":1120,"width":787,"height":283},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3ebaed918974171878c6918de0e8278","type":"complex_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","children_ids":["a09bd2b2ff144154b3fb18a655cfe4dd","aa2fb25241cf4e5da4e6febbcd6ea2c1","82a15a83f04142adb41de1ad305389c8","48192649b8454ff4b4eeb7b7ceb41589","95b1642954f14839b9b2e27fba9829b3","0c586e09b9b74883997c325e01c88437"],"text":"A PHASE IIIB, DOUBLE-BLIND, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILD STROKE (RAPIDLY IMPROVING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)","text_display":"A PHASE IIIB, DOUBLE-BLIND, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILD STROKE (RAPIDLY IMPROVING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.998046875,"confidence_rate":0.9999833392669365},{"cnt":[[910,1125],[1687,1125],[1687,1164],[910,1164]],"region":{"top_left_x":910,"top_left_y":1125,"width":778,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a09bd2b2ff144154b3fb18a655cfe4dd","type":"text","conversion_output":false,"parent_id":"e3ebaed918974171878c6918de0e8278","text":"A PHASE IIIB, DOUBLE-BLIND, MULTICENTER","text_display":"A PHASE IIIB, DOUBLE-BLIND, MULTICENTER","confidence":0.99951171875,"confidence_rate":0.9999889000502842},{"cnt":[[910,1168],[1640,1168],[1640,1207],[910,1207]],"region":{"top_left_x":910,"top_left_y":1168,"width":730,"height":40},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa2fb25241cf4e5da4e6febbcd6ea2c1","type":"text","conversion_output":false,"parent_id":"e3ebaed918974171878c6918de0e8278","text":"STUDY TO EVALUATE THE EFFICACY AND","text_display":" STUDY TO EVALUATE THE EFFICACY AND","confidence":1,"confidence_rate":1},{"cnt":[[910,1216],[1655,1216],[1655,1255],[910,1255]],"region":{"top_left_x":910,"top_left_y":1215,"width":746,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82a15a83f04142adb41de1ad305389c8","type":"text","conversion_output":false,"parent_id":"e3ebaed918974171878c6918de0e8278","text":"SAFETY OF ALTEPLASE IN PATIENTS WITH","text_display":" SAFETY OF ALTEPLASE IN PATIENTS WITH","confidence":1,"confidence_rate":1},{"cnt":[[910,1259],[1540,1259],[1540,1305],[910,1305]],"region":{"top_left_x":910,"top_left_y":1259,"width":631,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48192649b8454ff4b4eeb7b7ceb41589","type":"text","conversion_output":false,"parent_id":"e3ebaed918974171878c6918de0e8278","text":"MILD STROKE (RAPIDLY IMPROVING","text_display":" MILD STROKE (RAPIDLY IMPROVING","confidence":1,"confidence_rate":1},{"cnt":[[910,1307],[1575,1307],[1575,1348],[910,1348]],"region":{"top_left_x":910,"top_left_y":1306,"width":665,"height":43},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95b1642954f14839b9b2e27fba9829b3","type":"text","conversion_output":false,"parent_id":"e3ebaed918974171878c6918de0e8278","text":"SYMPTOMS AND MINOR NEUROLOGIC","text_display":" SYMPTOMS AND MINOR NEUROLOGIC","confidence":1,"confidence_rate":1},{"cnt":[[910,1355],[1244,1355],[1244,1400],[910,1400]],"region":{"top_left_x":910,"top_left_y":1354,"width":334,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c586e09b9b74883997c325e01c88437","type":"text","conversion_output":false,"parent_id":"e3ebaed918974171878c6918de0e8278","text":"DEFICITS (PRISMS)","text_display":" DEFICITS (PRISMS)","confidence":0.998046875,"confidence_rate":0.9999111387285874},{"cnt":[[442,1437],[618,1437],[618,1474],[442,1474]],"region":{"top_left_x":442,"top_left_y":1436,"width":176,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"067755ea652b4398ac49d56d07c734d1","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"VERSION:","text_display":"VERSION:","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[914,1437],[971,1437],[971,1476],[914,1476]],"region":{"top_left_x":914,"top_left_y":1436,"width":57,"height":40},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a10a8b4fbd7a422aa5dc3a64b1d8207f","type":"simple_cell","conversion_output":false,"parent_id":"fa9ff808a0264882b6c62bea347766b5","text":"1.0","text_display":"1.0","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[460,2142],[638,2142],[638,2176],[460,2176]],"region":{"top_left_x":459,"top_left_y":2141,"width":180,"height":36},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"576558e87c424cb18f1cfad9029c009a","type":"section_header","conversion_output":false,"children_ids":["b419c3ac45bc47609dc444f0f69c9733"],"text":"","text_display":""},{"cnt":[[460,2144],[634,2144],[634,2172],[460,2172]],"region":{"top_left_x":459,"top_left_y":2144,"width":175,"height":29},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b419c3ac45bc47609dc444f0f69c9733","type":"text","conversion_output":true,"parent_id":"576558e87c424cb18f1cfad9029c009a","text":"Confidential","text_display":"\n\n\\section*{Confidential}","confidence":1,"confidence_rate":1},{"cnt":[[1091,2144],[1190,2144],[1190,2181],[1091,2181]],"region":{"top_left_x":1091,"top_left_y":2144,"width":100,"height":37},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"42c958dc97b14814a327ab212a47ee2f","type":"section_header","conversion_output":false,"children_ids":["c5bead61ec944d9999e6b4073c3abb94"],"text":"","text_display":""},{"cnt":[[1091,2144],[1188,2144],[1188,2176],[1091,2176]],"region":{"top_left_x":1091,"top_left_y":2144,"width":98,"height":33},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c5bead61ec944d9999e6b4073c3abb94","type":"text","conversion_output":true,"parent_id":"42c958dc97b14814a327ab212a47ee2f","text":"Page 1","text_display":"\n\n\\section*{Page 1}","confidence":1,"confidence_rate":1},{"cnt":[[466,2213],[1708,2213],[1708,2249],[466,2249]],"region":{"top_left_x":466,"top_left_y":2212,"width":1243,"height":38},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"69a4c5e0322a4e06b76291708f46adf4","type":"text","conversion_output":true,"text":"This is a Genentech, Inc. document that contains confidential information. Nothing herein is to be","text_display":"\n\nThis is a Genentech, Inc. document that contains confidential information. Nothing herein is to be","confidence":1,"confidence_rate":1},{"cnt":[[735,2247],[1439,2247],[1439,2279],[735,2279]],"region":{"top_left_x":734,"top_left_y":2247,"width":706,"height":33},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e23bfe79d0b8480b85334b66cddda24b","type":"text","conversion_output":true,"text":"disclosed without written consent from Genentech, Inc.","text_display":" disclosed without written consent from Genentech, Inc.","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1201,2368],[1201,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":42},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8c9b6906374c47c1a9554818faeb9fc0","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[436,2402],[587,2402],[587,2434],[436,2434]],"region":{"top_left_x":436,"top_left_y":2401,"width":151,"height":34},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1cdfba213f7f462ea619fb965c3816df","type":"page_info","conversion_output":false,"text":"1/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":34},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ba97a9ad5b754a08bd89915b045056b9","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be37b054a54843c89e7311178f1f9257","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922046510095575,"confidence_rate":0.9998796089159951},{"cnt":[[372,2608],[694,2608],[694,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"559604fae88849d8a1a4ccce49a6ab1c","type":"page_info","conversion_output":false,"text":"762/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-03","page":3,"lines":[{"cnt":[[896,455],[1280,455],[1280,494],[896,494]],"region":{"top_left_x":895,"top_left_y":455,"width":386,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87aba431cbc24ba09ee52e2f1cc9f1f1","type":"section_header","conversion_output":false,"children_ids":["69a66a2bdea846869e3a5932a5bee9ae"],"text":"","text_display":""},{"cnt":[[898,460],[1276,460],[1276,490],[898,490]],"region":{"top_left_x":898,"top_left_y":459,"width":379,"height":31},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69a66a2bdea846869e3a5932a5bee9ae","type":"text","conversion_output":true,"parent_id":"87aba431cbc24ba09ee52e2f1cc9f1f1","text":"TABLE OF CONTENTS","text_display":"\n\n\\section*{TABLE OF CONTENTS}","confidence":0.99951171875,"confidence_rate":0.9999778002237774},{"cnt":[[425,518],[1749,518],[1749,2325],[425,2325]],"region":{"top_left_x":425,"top_left_y":517,"width":1324,"height":1808},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16f4851c02a84330bc7bd2cb5a02af68","type":"table_of_contents_container","conversion_output":false,"children_ids":["ef352001245347d288f4ffce37353061","ae69bbee1f33472fad21f66a150768be","ed9ab905691f4bb0b97383339890a2ae","0a3232531e1c4b6f9bf2a11148a5b910","0f6ef016627340a3bac4a3436c04b837","cd1f82e5bf1f4eb5922ad2dfcd8b374b","6c946d476ded4c4aa308b8975bec065c","6f8091573ec1413781a1aba76f2d4316","90ca20d666e7493788b08cd2caf598df","3274da1c90b34497a6a192540c908d44","11d91724a5014b669f6c541278863b6e","809825ea822d4584a649400cf0bde2ca","cda7072d801d44bbb392677bcda46016","532b3b097357469198c3b1405d41ad66","1942541caf8d4d679e72b7af1ff3b3d7","f996a541b7014a0d9696cb6f56075545","e36268a4a43a49b291af893d73957fbd","17b1b0391d5d4708ba2ac99181f52c3f","34b08860a8d5492cb05530f82c74d9db","06c0967421104fc29c300b013e00c97a","1c392c8ad1fd41fa9e51b785445fb2b4","a31cca87e4e04ad5b74d4f2489411786","2d08107606d643fca43dc96ca325b8bf","b44e2a95363c49c296441c8fb16dba54","052bf857b6054dab93e98f4c022d8781","2d94832fbfb14ca5898b43a27dfac5bb","91d5f0f174c7493a9813f2348842c9aa","470c8587f862449285b41ad2f64d3194","83ad84e736ce404391486cae6e4f3795","46a1e77fcc764599b36c547ae93084f2","cd2b2ad174d94bcf84cbfa7b794e7d95","071f83b81d3e4581817f859ac3b8990b","ef808359965c4880a8ad041a6deab96f","b881b8ae5ea04e35851e8ddbb0ea8c19","beecb4c8c87d4150a97928e336f23d5f"],"text":"","text_display":""},{"cnt":[[1654,524],[1742,524],[1742,565],[1654,565]],"region":{"top_left_x":1654,"top_left_y":524,"width":89,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef352001245347d288f4ffce37353061","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["5e4376534a794205961c7680baa3e49a"],"text":"","text_display":""},{"cnt":[[1654,526],[1740,526],[1740,563],[1654,563]],"region":{"top_left_x":1654,"top_left_y":526,"width":87,"height":37},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e4376534a794205961c7680baa3e49a","type":"table_of_contents_item","conversion_output":true,"parent_id":"ef352001245347d288f4ffce37353061","text":"Page","text_display":"\nPage","confidence":1,"confidence_rate":1},{"cnt":[[434,606],[1732,606],[1732,647],[434,647]],"region":{"top_left_x":433,"top_left_y":605,"width":1299,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae69bbee1f33472fad21f66a150768be","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["68444249ab9340f587503fb7879df637","f6a5d9d04f744968a5dbcf16f2aa79e1"],"text":"","text_display":""},{"cnt":[[438,610],[761,610],[761,642],[438,642]],"region":{"top_left_x":438,"top_left_y":610,"width":323,"height":33},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68444249ab9340f587503fb7879df637","type":"table_of_contents_item","conversion_output":true,"parent_id":"ae69bbee1f33472fad21f66a150768be","text":"1. BACKGROUND","text_display":"\n1. BACKGROUND","confidence":1,"confidence_rate":1},{"cnt":[[1706,606],[1732,606],[1732,645],[1706,645]],"region":{"top_left_x":1705,"top_left_y":605,"width":27,"height":40},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6a5d9d04f744968a5dbcf16f2aa79e1","type":"table_of_contents_number","conversion_output":true,"parent_id":"ae69bbee1f33472fad21f66a150768be","text":"5","text_display":" ..... 5","confidence":1,"confidence_rate":1},{"cnt":[[432,657],[1732,657],[1732,698],[432,698]],"region":{"top_left_x":431,"top_left_y":657,"width":1301,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed9ab905691f4bb0b97383339890a2ae","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["9821ad18be914fe8a5bf079e44f64727","e7d9b55018304270b766c87b6d826f4a"],"text":"","text_display":""},{"cnt":[[434,662],[776,662],[776,694],[434,694]],"region":{"top_left_x":433,"top_left_y":661,"width":343,"height":33},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9821ad18be914fe8a5bf079e44f64727","type":"table_of_contents_item","conversion_output":true,"parent_id":"ed9ab905691f4bb0b97383339890a2ae","text":"2. STUDY DESIGN","text_display":"\n2. STUDY DESIGN","confidence":1,"confidence_rate":1},{"cnt":[[1706,657],[1732,657],[1732,696],[1706,696]],"region":{"top_left_x":1705,"top_left_y":657,"width":27,"height":40},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7d9b55018304270b766c87b6d826f4a","type":"table_of_contents_number","conversion_output":true,"parent_id":"ed9ab905691f4bb0b97383339890a2ae","text":"6","text_display":" ..... 6","confidence":0.99951171875,"confidence_rate":0.99951171875},{"cnt":[[505,707],[1732,707],[1732,752],[505,752]],"region":{"top_left_x":504,"top_left_y":706,"width":1228,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a3232531e1c4b6f9bf2a11148a5b910","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["0ca0c4be44284aaeab74793ab1b4040d","af6991bb5a6e4972a455e5945a0e9b21"],"text":"","text_display":""},{"cnt":[[507,709],[758,709],[758,750],[507,750]],"region":{"top_left_x":507,"top_left_y":708,"width":252,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ca0c4be44284aaeab74793ab1b4040d","type":"table_of_contents_item","conversion_output":true,"parent_id":"0a3232531e1c4b6f9bf2a11148a5b910","text":"2.1 Synopsis","text_display":"\n2.1 Synopsis","confidence":1,"confidence_rate":1},{"cnt":[[1706,709],[1732,709],[1732,743],[1706,743]],"region":{"top_left_x":1705,"top_left_y":708,"width":27,"height":36},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af6991bb5a6e4972a455e5945a0e9b21","type":"table_of_contents_number","conversion_output":true,"parent_id":"0a3232531e1c4b6f9bf2a11148a5b910","text":"6","text_display":" ..... 6","confidence":1,"confidence_rate":1},{"cnt":[[507,756],[1732,756],[1732,797],[507,797]],"region":{"top_left_x":507,"top_left_y":756,"width":1225,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f6ef016627340a3bac4a3436c04b837","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["4181f798bd2a468b9e00120cb1a9cb7e","48b971d44b5d4e998644ec63a7a82e68"],"text":"","text_display":""},{"cnt":[[507,761],[922,761],[922,793],[507,793]],"region":{"top_left_x":507,"top_left_y":760,"width":415,"height":33},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4181f798bd2a468b9e00120cb1a9cb7e","type":"table_of_contents_item","conversion_output":true,"parent_id":"0f6ef016627340a3bac4a3436c04b837","text":"2.2 Outcome Measures","text_display":"\n2.2 Outcome Measures","confidence":1,"confidence_rate":1},{"cnt":[[1706,761],[1732,761],[1732,795],[1706,795]],"region":{"top_left_x":1705,"top_left_y":760,"width":27,"height":35},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48b971d44b5d4e998644ec63a7a82e68","type":"table_of_contents_number","conversion_output":true,"parent_id":"0f6ef016627340a3bac4a3436c04b837","text":"6","text_display":" ..... 6","confidence":0.99951171875,"confidence_rate":0.99951171875},{"cnt":[[610,804],[1732,804],[1732,851],[610,851]],"region":{"top_left_x":610,"top_left_y":803,"width":1122,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd1f82e5bf1f4eb5922ad2dfcd8b374b","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["ae2504f963824394ba8a97a13bd49026","255e83db5e084e81a6257bcf3dd6d9da"],"text":"","text_display":""},{"cnt":[[612,808],[1313,808],[1313,849],[612,849]],"region":{"top_left_x":612,"top_left_y":807,"width":701,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae2504f963824394ba8a97a13bd49026","type":"table_of_contents_item","conversion_output":true,"parent_id":"cd1f82e5bf1f4eb5922ad2dfcd8b374b","text":"2.2.1 Primary Efficacy Outcome Measures","text_display":"\n2.2.1 Primary Efficacy Outcome Measures","confidence":1,"confidence_rate":1},{"cnt":[[1706,808],[1732,808],[1732,842],[1706,842]],"region":{"top_left_x":1705,"top_left_y":807,"width":27,"height":36},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"255e83db5e084e81a6257bcf3dd6d9da","type":"table_of_contents_number","conversion_output":true,"parent_id":"cd1f82e5bf1f4eb5922ad2dfcd8b374b","text":"6","text_display":" ..... 6","confidence":1,"confidence_rate":1},{"cnt":[[610,855],[1732,855],[1732,900],[610,900]],"region":{"top_left_x":610,"top_left_y":855,"width":1122,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c946d476ded4c4aa308b8975bec065c","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["a70f622516f34788834c3479262b5ff0","7582c8a355a8477bb7b25744e060bb91"],"text":"","text_display":""},{"cnt":[[612,855],[1360,855],[1360,896],[612,896]],"region":{"top_left_x":612,"top_left_y":855,"width":748,"height":41},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a70f622516f34788834c3479262b5ff0","type":"table_of_contents_item","conversion_output":true,"parent_id":"6c946d476ded4c4aa308b8975bec065c","text":"2.2.2 Secondary Efficacy Outcome Measures","text_display":"\n2.2.2 Secondary Efficacy Outcome Measures","confidence":1,"confidence_rate":1},{"cnt":[[1706,859],[1732,859],[1732,892],[1706,892]],"region":{"top_left_x":1705,"top_left_y":859,"width":27,"height":33},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7582c8a355a8477bb7b25744e060bb91","type":"table_of_contents_number","conversion_output":true,"parent_id":"6c946d476ded4c4aa308b8975bec065c","text":"6","text_display":" ..... 6","confidence":1,"confidence_rate":1},{"cnt":[[610,902],[1732,902],[1732,950],[610,950]],"region":{"top_left_x":610,"top_left_y":902,"width":1122,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f8091573ec1413781a1aba76f2d4316","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["46d9a5f835db4347be9b02a0755c24ea","542db2a6857f40f583947e91bb5a6516"],"text":"","text_display":""},{"cnt":[[612,907],[1369,907],[1369,947],[612,947]],"region":{"top_left_x":612,"top_left_y":906,"width":757,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46d9a5f835db4347be9b02a0755c24ea","type":"table_of_contents_item","conversion_output":true,"parent_id":"6f8091573ec1413781a1aba76f2d4316","text":"2.2.3 Exploratory Efficacy Outcome Measures","text_display":"\n2.2.3 Exploratory Efficacy Outcome Measures","confidence":1,"confidence_rate":1},{"cnt":[[1706,900],[1732,900],[1732,941],[1706,941]],"region":{"top_left_x":1705,"top_left_y":900,"width":27,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"542db2a6857f40f583947e91bb5a6516","type":"table_of_contents_number","conversion_output":true,"parent_id":"6f8091573ec1413781a1aba76f2d4316","text":"7","text_display":" ..... 7","confidence":1,"confidence_rate":1},{"cnt":[[610,952],[1732,952],[1732,999],[610,999]],"region":{"top_left_x":610,"top_left_y":951,"width":1122,"height":49},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90ca20d666e7493788b08cd2caf598df","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["9a5b0183ae784689857f3b2ee215a18d","f4012e9c55eb494ba9dce78268042bf9"],"text":"","text_display":""},{"cnt":[[614,956],[1158,956],[1158,995],[614,995]],"region":{"top_left_x":614,"top_left_y":956,"width":545,"height":39},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a5b0183ae784689857f3b2ee215a18d","type":"table_of_contents_item","conversion_output":true,"parent_id":"90ca20d666e7493788b08cd2caf598df","text":"2.2.4 Safety Outcome Measures","text_display":"\n2.2.4 Safety Outcome Measures","confidence":0.9990234375,"confidence_rate":0.9999712639526579},{"cnt":[[1706,952],[1732,952],[1732,988],[1706,988]],"region":{"top_left_x":1705,"top_left_y":951,"width":27,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4012e9c55eb494ba9dce78268042bf9","type":"table_of_contents_number","conversion_output":true,"parent_id":"90ca20d666e7493788b08cd2caf598df","text":"7","text_display":" ..... 7","confidence":1,"confidence_rate":1},{"cnt":[[505,1001],[1732,1001],[1732,1046],[505,1046]],"region":{"top_left_x":504,"top_left_y":1001,"width":1228,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3274da1c90b34497a6a192540c908d44","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["0d502e912acc436185bc4d268a6e869c","855c9250b9b44387ba2642c5fe5f4c03"],"text":"","text_display":""},{"cnt":[[507,1005],[1076,1005],[1076,1044],[507,1044]],"region":{"top_left_x":507,"top_left_y":1005,"width":570,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d502e912acc436185bc4d268a6e869c","type":"table_of_contents_item","conversion_output":true,"parent_id":"3274da1c90b34497a6a192540c908d44","text":"2.3 Determination of Sample Size","text_display":"\n2.3 Determination of Sample Size","confidence":1,"confidence_rate":1},{"cnt":[[1706,1003],[1732,1003],[1732,1040],[1706,1040]],"region":{"top_left_x":1705,"top_left_y":1003,"width":27,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"855c9250b9b44387ba2642c5fe5f4c03","type":"table_of_contents_number","conversion_output":true,"parent_id":"3274da1c90b34497a6a192540c908d44","text":"8","text_display":" ..... 8","confidence":1,"confidence_rate":1},{"cnt":[[505,1053],[1732,1053],[1732,1098],[505,1098]],"region":{"top_left_x":504,"top_left_y":1052,"width":1228,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11d91724a5014b669f6c541278863b6e","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["c02cc12d04694e669767e85d5a8fc0f2","e66eedf0950540f1bfaf7ca28e6394c1"],"text":"","text_display":""},{"cnt":[[507,1053],[862,1053],[862,1094],[507,1094]],"region":{"top_left_x":507,"top_left_y":1052,"width":355,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c02cc12d04694e669767e85d5a8fc0f2","type":"table_of_contents_item","conversion_output":true,"parent_id":"11d91724a5014b669f6c541278863b6e","text":"2.4 Analysis Timing","text_display":"\n2.4 Analysis Timing","confidence":1,"confidence_rate":1},{"cnt":[[1706,1055],[1732,1055],[1732,1089],[1706,1089]],"region":{"top_left_x":1705,"top_left_y":1054,"width":27,"height":36},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e66eedf0950540f1bfaf7ca28e6394c1","type":"table_of_contents_number","conversion_output":true,"parent_id":"11d91724a5014b669f6c541278863b6e","text":"9","text_display":" ..... 9","confidence":1,"confidence_rate":1},{"cnt":[[434,1100],[1732,1100],[1732,1141],[434,1141]],"region":{"top_left_x":433,"top_left_y":1100,"width":1299,"height":41},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"809825ea822d4584a649400cf0bde2ca","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["1c456c6170974e3c81ae2abc7e21b416","b6fd1a70aaea45f9ae5592efce874e47"],"text":"","text_display":""},{"cnt":[[434,1104],[814,1104],[814,1137],[434,1137]],"region":{"top_left_x":433,"top_left_y":1104,"width":382,"height":33},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c456c6170974e3c81ae2abc7e21b416","type":"table_of_contents_item","conversion_output":true,"parent_id":"809825ea822d4584a649400cf0bde2ca","text":"3. STUDY CONDUCT","text_display":"\n3. STUDY CONDUCT","confidence":1,"confidence_rate":1},{"cnt":[[1706,1104],[1732,1104],[1732,1141],[1706,1141]],"region":{"top_left_x":1705,"top_left_y":1104,"width":27,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6fd1a70aaea45f9ae5592efce874e47","type":"table_of_contents_number","conversion_output":true,"parent_id":"809825ea822d4584a649400cf0bde2ca","text":"9","text_display":" ..... 9","confidence":1,"confidence_rate":1},{"cnt":[[507,1147],[1732,1147],[1732,1188],[507,1188]],"region":{"top_left_x":507,"top_left_y":1147,"width":1225,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cda7072d801d44bbb392677bcda46016","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["4e1d5ad390154dc5b827701669af5347","e4026b64ae004899a9722d1ed3b3eb86"],"text":"","text_display":""},{"cnt":[[509,1152],[960,1152],[960,1188],[509,1188]],"region":{"top_left_x":509,"top_left_y":1151,"width":452,"height":38},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e1d5ad390154dc5b827701669af5347","type":"table_of_contents_item","conversion_output":true,"parent_id":"cda7072d801d44bbb392677bcda46016","text":"3.1 Randomization Issues","text_display":"\n3.1 Randomization Issues","confidence":1,"confidence_rate":1},{"cnt":[[1706,1152],[1732,1152],[1732,1186],[1706,1186]],"region":{"top_left_x":1705,"top_left_y":1151,"width":27,"height":35},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4026b64ae004899a9722d1ed3b3eb86","type":"table_of_contents_number","conversion_output":true,"parent_id":"cda7072d801d44bbb392677bcda46016","text":"9","text_display":" ..... 9","confidence":1,"confidence_rate":1},{"cnt":[[507,1199],[1732,1199],[1732,1244],[507,1244]],"region":{"top_left_x":507,"top_left_y":1198,"width":1225,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"532b3b097357469198c3b1405d41ad66","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["76e9595860f44ed2bfe57615d9a8b61c","cdc33d3d6ba24302b177a80e958b11d8"],"text":"","text_display":""},{"cnt":[[507,1199],[862,1199],[862,1240],[507,1240]],"region":{"top_left_x":507,"top_left_y":1198,"width":355,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76e9595860f44ed2bfe57615d9a8b61c","type":"table_of_contents_item","conversion_output":true,"parent_id":"532b3b097357469198c3b1405d41ad66","text":"3.2 Data Monitoring","text_display":"\n3.2 Data Monitoring","confidence":1,"confidence_rate":1},{"cnt":[[1689,1203],[1732,1203],[1732,1238],[1689,1238]],"region":{"top_left_x":1688,"top_left_y":1203,"width":44,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdc33d3d6ba24302b177a80e958b11d8","type":"table_of_contents_number","conversion_output":true,"parent_id":"532b3b097357469198c3b1405d41ad66","text":"10","text_display":" ..... 10","confidence":1,"confidence_rate":1},{"cnt":[[610,1246],[1732,1246],[1732,1291],[610,1291]],"region":{"top_left_x":610,"top_left_y":1246,"width":1122,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1942541caf8d4d679e72b7af1ff3b3d7","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["b86c5831638743398220143a55951f0f","a9508c5d9eba4077886a6aca6b12ad1c"],"text":"","text_display":""},{"cnt":[[614,1250],[1085,1250],[1085,1291],[614,1291]],"region":{"top_left_x":614,"top_left_y":1250,"width":471,"height":42},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b86c5831638743398220143a55951f0f","type":"table_of_contents_item","conversion_output":true,"parent_id":"1942541caf8d4d679e72b7af1ff3b3d7","text":"3.2.1 Safety Review Timing","text_display":"\n3.2.1 Safety Review Timing","confidence":1,"confidence_rate":1},{"cnt":[[1689,1244],[1732,1244],[1732,1285],[1689,1285]],"region":{"top_left_x":1688,"top_left_y":1243,"width":44,"height":42},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9508c5d9eba4077886a6aca6b12ad1c","type":"table_of_contents_number","conversion_output":true,"parent_id":"1942541caf8d4d679e72b7af1ff3b3d7","text":"10","text_display":" ..... 10","confidence":1,"confidence_rate":1},{"cnt":[[432,1298],[1729,1298],[1729,1338],[432,1338]],"region":{"top_left_x":431,"top_left_y":1297,"width":1299,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f996a541b7014a0d9696cb6f56075545","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["2840cba6a9054c668aa1cd00e910af2c","9cfa640f92b141aa93d27dee71d2f2ba"],"text":"","text_display":""},{"cnt":[[434,1302],[915,1302],[915,1334],[434,1334]],"region":{"top_left_x":433,"top_left_y":1301,"width":483,"height":34},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2840cba6a9054c668aa1cd00e910af2c","type":"table_of_contents_item","conversion_output":true,"parent_id":"f996a541b7014a0d9696cb6f56075545","text":"4. STATISTICAL METHODS","text_display":"\n4. STATISTICAL METHODS","confidence":0.99951171875,"confidence_rate":0.9999819112562659},{"cnt":[[1689,1296],[1732,1296],[1732,1336],[1689,1336]],"region":{"top_left_x":1688,"top_left_y":1295,"width":44,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cfa640f92b141aa93d27dee71d2f2ba","type":"table_of_contents_number","conversion_output":true,"parent_id":"f996a541b7014a0d9696cb6f56075545","text":"11","text_display":" ..... 11","confidence":1,"confidence_rate":1},{"cnt":[[503,1345],[1729,1345],[1729,1390],[503,1390]],"region":{"top_left_x":502,"top_left_y":1344,"width":1228,"height":47},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e36268a4a43a49b291af893d73957fbd","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["c09443a9cbd146a28631db374c8b164a","bb1ca19489b848b8930bd3871d48032e"],"text":"","text_display":""},{"cnt":[[507,1349],[937,1349],[937,1388],[507,1388]],"region":{"top_left_x":507,"top_left_y":1349,"width":430,"height":39},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c09443a9cbd146a28631db374c8b164a","type":"table_of_contents_item","conversion_output":true,"parent_id":"e36268a4a43a49b291af893d73957fbd","text":"4.1 Analysis Populations","text_display":"\n4.1 Analysis Populations","confidence":1,"confidence_rate":1},{"cnt":[[1689,1347],[1729,1347],[1729,1384],[1689,1384]],"region":{"top_left_x":1688,"top_left_y":1347,"width":42,"height":37},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb1ca19489b848b8930bd3871d48032e","type":"table_of_contents_number","conversion_output":true,"parent_id":"e36268a4a43a49b291af893d73957fbd","text":"11","text_display":" ..... 11","confidence":1,"confidence_rate":1},{"cnt":[[610,1396],[1729,1396],[1729,1439],[610,1439]],"region":{"top_left_x":610,"top_left_y":1396,"width":1120,"height":44},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17b1b0391d5d4708ba2ac99181f52c3f","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["f9c8ddea938245d2b3b8955397859359","b0cabb7e6c184f879189c4336fa60143"],"text":"","text_display":""},{"cnt":[[610,1396],[1141,1396],[1141,1437],[610,1437]],"region":{"top_left_x":610,"top_left_y":1396,"width":531,"height":42},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9c8ddea938245d2b3b8955397859359","type":"table_of_contents_item","conversion_output":true,"parent_id":"17b1b0391d5d4708ba2ac99181f52c3f","text":"4.1.1 Intent-to-Treat Population","text_display":"\n4.1.1 Intent-to-Treat Population","confidence":1,"confidence_rate":1},{"cnt":[[1689,1396],[1729,1396],[1729,1435],[1689,1435]],"region":{"top_left_x":1688,"top_left_y":1396,"width":42,"height":40},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0cabb7e6c184f879189c4336fa60143","type":"table_of_contents_number","conversion_output":true,"parent_id":"17b1b0391d5d4708ba2ac99181f52c3f","text":"11","text_display":" ..... 11","confidence":1,"confidence_rate":1},{"cnt":[[610,1444],[1729,1444],[1729,1489],[610,1489]],"region":{"top_left_x":610,"top_left_y":1443,"width":1120,"height":46},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34b08860a8d5492cb05530f82c74d9db","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["a6972668a2f345bcb087aa057d6dae0a","cfbaeb1a400e4ea4b78345ba512a11a2"],"text":"","text_display":""},{"cnt":[[610,1448],[1115,1448],[1115,1487],[610,1487]],"region":{"top_left_x":610,"top_left_y":1448,"width":506,"height":39},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6972668a2f345bcb087aa057d6dae0a","type":"table_of_contents_item","conversion_output":true,"parent_id":"34b08860a8d5492cb05530f82c74d9db","text":"4.1.2 Per-Protocol Population","text_display":"\n4.1.2 Per-Protocol Population","confidence":1,"confidence_rate":1},{"cnt":[[1689,1448],[1729,1448],[1729,1487],[1689,1487]],"region":{"top_left_x":1688,"top_left_y":1448,"width":42,"height":39},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfbaeb1a400e4ea4b78345ba512a11a2","type":"table_of_contents_number","conversion_output":true,"parent_id":"34b08860a8d5492cb05530f82c74d9db","text":"11","text_display":" ..... 11","confidence":1,"confidence_rate":1},{"cnt":[[610,1491],[1732,1491],[1732,1538],[610,1538]],"region":{"top_left_x":610,"top_left_y":1491,"width":1122,"height":48},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06c0967421104fc29c300b013e00c97a","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["fbd63071424c459b86f2fa3b761b7152","9e8e4e2e51874422935786edd4cafb1b"],"text":"","text_display":""},{"cnt":[[610,1495],[1021,1495],[1021,1536],[610,1536]],"region":{"top_left_x":610,"top_left_y":1495,"width":411,"height":42},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbd63071424c459b86f2fa3b761b7152","type":"table_of_contents_item","conversion_output":true,"parent_id":"06c0967421104fc29c300b013e00c97a","text":"4.1.3 Safety Population","text_display":"\n4.1.3 Safety Population","confidence":0.9990234375,"confidence_rate":0.9999651063356614},{"cnt":[[1689,1495],[1732,1495],[1732,1536],[1689,1536]],"region":{"top_left_x":1688,"top_left_y":1495,"width":44,"height":42},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e8e4e2e51874422935786edd4cafb1b","type":"table_of_contents_number","conversion_output":true,"parent_id":"06c0967421104fc29c300b013e00c97a","text":"12","text_display":" ..... 12","confidence":1,"confidence_rate":1},{"cnt":[[503,1543],[1732,1543],[1732,1588],[503,1588]],"region":{"top_left_x":502,"top_left_y":1542,"width":1230,"height":46},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c392c8ad1fd41fa9e51b785445fb2b4","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["ef9005bf9712414ba8b2043e5a0a5c22","295b570554d349869563a8cbaeef468a"],"text":"","text_display":""},{"cnt":[[507,1545],[1025,1545],[1025,1583],[507,1583]],"region":{"top_left_x":507,"top_left_y":1544,"width":518,"height":40},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef9005bf9712414ba8b2043e5a0a5c22","type":"table_of_contents_item","conversion_output":true,"parent_id":"1c392c8ad1fd41fa9e51b785445fb2b4","text":"4.2 Analysis of Study Conduct","text_display":"\n4.2 Analysis of Study Conduct","confidence":1,"confidence_rate":1},{"cnt":[[1689,1538],[1732,1538],[1732,1581],[1689,1581]],"region":{"top_left_x":1688,"top_left_y":1538,"width":44,"height":44},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"295b570554d349869563a8cbaeef468a","type":"table_of_contents_number","conversion_output":true,"parent_id":"1c392c8ad1fd41fa9e51b785445fb2b4","text":"12","text_display":" ..... 12","confidence":1,"confidence_rate":1},{"cnt":[[505,1592],[1732,1592],[1732,1637],[505,1637]],"region":{"top_left_x":504,"top_left_y":1591,"width":1228,"height":47},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a31cca87e4e04ad5b74d4f2489411786","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["e00e3cbcd56346b5ac83e4ad1bb874fd","c618af2f493e4c4ba78d7f92359532ad"],"text":"","text_display":""},{"cnt":[[507,1594],[1283,1594],[1283,1635],[507,1635]],"region":{"top_left_x":507,"top_left_y":1594,"width":776,"height":41},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e00e3cbcd56346b5ac83e4ad1bb874fd","type":"table_of_contents_item","conversion_output":true,"parent_id":"a31cca87e4e04ad5b74d4f2489411786","text":"4.3 Analysis of Treatment Group Comparability","text_display":"\n4.3 Analysis of Treatment Group Comparability","confidence":1,"confidence_rate":1},{"cnt":[[1689,1590],[1732,1590],[1732,1629],[1689,1629]],"region":{"top_left_x":1688,"top_left_y":1589,"width":44,"height":40},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c618af2f493e4c4ba78d7f92359532ad","type":"table_of_contents_number","conversion_output":true,"parent_id":"a31cca87e4e04ad5b74d4f2489411786","text":"12","text_display":" ..... 12","confidence":1,"confidence_rate":1},{"cnt":[[503,1641],[1732,1641],[1732,1687],[503,1687]],"region":{"top_left_x":502,"top_left_y":1641,"width":1230,"height":46},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d08107606d643fca43dc96ca325b8bf","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["d0cc5f338cfa43d891e93e5952e5514f","973fb3aff4154ddbbb33ec2509021a3d"],"text":"","text_display":""},{"cnt":[[507,1646],[889,1646],[889,1682],[507,1682]],"region":{"top_left_x":507,"top_left_y":1645,"width":383,"height":38},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0cc5f338cfa43d891e93e5952e5514f","type":"table_of_contents_item","conversion_output":true,"parent_id":"2d08107606d643fca43dc96ca325b8bf","text":"4.4 Efficacy Analyses","text_display":"\n4.4 Efficacy Analyses","confidence":0.9926907959161326,"confidence_rate":0.9997178841407337},{"cnt":[[1689,1641],[1732,1641],[1732,1680],[1689,1680]],"region":{"top_left_x":1688,"top_left_y":1641,"width":44,"height":40},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"973fb3aff4154ddbbb33ec2509021a3d","type":"table_of_contents_number","conversion_output":true,"parent_id":"2d08107606d643fca43dc96ca325b8bf","text":"13","text_display":" ..... 13","confidence":1,"confidence_rate":1},{"cnt":[[610,1689],[1732,1689],[1732,1738],[610,1738]],"region":{"top_left_x":610,"top_left_y":1688,"width":1122,"height":51},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b44e2a95363c49c296441c8fb16dba54","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["e55fbfb3e79e4f4a93d73f6f7ca54a70","a3916790ac3f45b480c2faa814cfb1b6"],"text":"","text_display":""},{"cnt":[[612,1693],[1147,1693],[1147,1734],[612,1734]],"region":{"top_left_x":612,"top_left_y":1692,"width":536,"height":42},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e55fbfb3e79e4f4a93d73f6f7ca54a70","type":"table_of_contents_item","conversion_output":true,"parent_id":"b44e2a95363c49c296441c8fb16dba54","text":"4.4.1 Primary Efficacy Endpoint","text_display":"\n4.4.1 Primary Efficacy Endpoint","confidence":1,"confidence_rate":1},{"cnt":[[1689,1693],[1732,1693],[1732,1727],[1689,1727]],"region":{"top_left_x":1688,"top_left_y":1692,"width":44,"height":36},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3916790ac3f45b480c2faa814cfb1b6","type":"table_of_contents_number","conversion_output":true,"parent_id":"b44e2a95363c49c296441c8fb16dba54","text":"14","text_display":" ..... 14","confidence":1,"confidence_rate":1},{"cnt":[[610,1740],[1732,1740],[1732,1785],[610,1785]],"region":{"top_left_x":610,"top_left_y":1740,"width":1122,"height":46},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"052bf857b6054dab93e98f4c022d8781","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["315bf0fcf04148d78281ba8d4952ada6","3db6822c946147d88f2e14d84d08f656"],"text":"","text_display":""},{"cnt":[[610,1740],[1210,1740],[1210,1781],[610,1781]],"region":{"top_left_x":610,"top_left_y":1740,"width":600,"height":42},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"315bf0fcf04148d78281ba8d4952ada6","type":"table_of_contents_item","conversion_output":true,"parent_id":"052bf857b6054dab93e98f4c022d8781","text":"4.4.2 Secondary Efficacy Endpoints","text_display":"\n4.4.2 Secondary Efficacy Endpoints","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[1689,1740],[1732,1740],[1732,1779],[1689,1779]],"region":{"top_left_x":1688,"top_left_y":1740,"width":44,"height":39},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3db6822c946147d88f2e14d84d08f656","type":"table_of_contents_number","conversion_output":true,"parent_id":"052bf857b6054dab93e98f4c022d8781","text":"15","text_display":" ..... 15","confidence":1,"confidence_rate":1},{"cnt":[[610,1788],[1732,1788],[1732,1833],[610,1833]],"region":{"top_left_x":610,"top_left_y":1787,"width":1122,"height":46},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d94832fbfb14ca5898b43a27dfac5bb","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["99598cc6ca934eaab09504342c69cc0a","e792ab9293444ffc8d155a084b8def27"],"text":"","text_display":""},{"cnt":[[612,1792],[1218,1792],[1218,1833],[612,1833]],"region":{"top_left_x":612,"top_left_y":1791,"width":607,"height":42},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99598cc6ca934eaab09504342c69cc0a","type":"table_of_contents_item","conversion_output":true,"parent_id":"2d94832fbfb14ca5898b43a27dfac5bb","text":"4.4.3 Exploratory Efficacy Endpoints","text_display":"\n4.4.3 Exploratory Efficacy Endpoints","confidence":1,"confidence_rate":1},{"cnt":[[1689,1792],[1732,1792],[1732,1830],[1689,1830]],"region":{"top_left_x":1688,"top_left_y":1791,"width":44,"height":40},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e792ab9293444ffc8d155a084b8def27","type":"table_of_contents_number","conversion_output":true,"parent_id":"2d94832fbfb14ca5898b43a27dfac5bb","text":"17","text_display":" ..... 17","confidence":1,"confidence_rate":1},{"cnt":[[610,1835],[1732,1835],[1732,1884],[610,1884]],"region":{"top_left_x":610,"top_left_y":1834,"width":1122,"height":51},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91d5f0f174c7493a9813f2348842c9aa","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["da6c4ff430d7471389e35de11f0b8b8a","5b17fdc5b37d40838a1d43d9ed8517c9"],"text":"","text_display":""},{"cnt":[[612,1839],[1051,1839],[1051,1880],[612,1880]],"region":{"top_left_x":612,"top_left_y":1839,"width":439,"height":41},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da6c4ff430d7471389e35de11f0b8b8a","type":"table_of_contents_item","conversion_output":true,"parent_id":"91d5f0f174c7493a9813f2348842c9aa","text":"4.4.4 Subgroup Analyses","text_display":"\n4.4.4 Subgroup Analyses","confidence":0.98583984375,"confidence_rate":0.9994907951228822},{"cnt":[[1689,1839],[1732,1839],[1732,1882],[1689,1882]],"region":{"top_left_x":1688,"top_left_y":1839,"width":44,"height":44},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b17fdc5b37d40838a1d43d9ed8517c9","type":"table_of_contents_number","conversion_output":true,"parent_id":"91d5f0f174c7493a9813f2348842c9aa","text":"19","text_display":" ..... 19","confidence":1,"confidence_rate":1},{"cnt":[[503,1886],[1734,1886],[1734,1972],[503,1972]],"region":{"top_left_x":502,"top_left_y":1886,"width":1232,"height":87},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"470c8587f862449285b41ad2f64d3194","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["73f38b701ddb4041a13eab435a4d05a0","b513d02f73df43af8d1f499ed5a3cb4c","26ddff6e6c274bf191cbd4433448139b"],"text":"","text_display":""},{"cnt":[[507,1891],[1433,1891],[1433,1931],[507,1931]],"region":{"top_left_x":507,"top_left_y":1890,"width":927,"height":42},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73f38b701ddb4041a13eab435a4d05a0","type":"table_of_contents_item","conversion_output":true,"parent_id":"470c8587f862449285b41ad2f64d3194","text":"4.5 Cognitive, Behavioral and Patient Reported Outcome","text_display":"\n4.5 Cognitive, Behavioral and Patient Reported Outcome","confidence":0.9990234375,"confidence_rate":0.9999834401430849},{"cnt":[[610,1929],[758,1929],[758,1970],[610,1970]],"region":{"top_left_x":610,"top_left_y":1929,"width":149,"height":42},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b513d02f73df43af8d1f499ed5a3cb4c","type":"table_of_contents_item","conversion_output":true,"parent_id":"470c8587f862449285b41ad2f64d3194","text":"Analyses","text_display":" Analyses","confidence":1,"confidence_rate":1},{"cnt":[[1684,1929],[1732,1929],[1732,1970],[1684,1970]],"region":{"top_left_x":1684,"top_left_y":1929,"width":48,"height":42},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26ddff6e6c274bf191cbd4433448139b","type":"table_of_contents_number","conversion_output":true,"parent_id":"470c8587f862449285b41ad2f64d3194","text":"22","text_display":" ..... 22","confidence":1,"confidence_rate":1},{"cnt":[[610,1977],[1732,1977],[1732,2022],[610,2022]],"region":{"top_left_x":610,"top_left_y":1976,"width":1122,"height":46},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83ad84e736ce404391486cae6e4f3795","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["436e15c2ca214e0aba73ab40fa3b6def","c27a666d08c24d22ab3124c5cc4fb462"],"text":"","text_display":""},{"cnt":[[610,1981],[1106,1981],[1106,2017],[610,2017]],"region":{"top_left_x":610,"top_left_y":1980,"width":497,"height":38},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"436e15c2ca214e0aba73ab40fa3b6def","type":"table_of_contents_item","conversion_output":true,"parent_id":"83ad84e736ce404391486cae6e4f3795","text":"4.5.1 Cognitive Assessments","text_display":"\n4.5.1 Cognitive Assessments","confidence":1,"confidence_rate":1},{"cnt":[[1684,1981],[1732,1981],[1732,2022],[1684,2022]],"region":{"top_left_x":1684,"top_left_y":1980,"width":48,"height":42},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c27a666d08c24d22ab3124c5cc4fb462","type":"table_of_contents_number","conversion_output":true,"parent_id":"83ad84e736ce404391486cae6e4f3795","text":"22","text_display":" ..... 22","confidence":1,"confidence_rate":1},{"cnt":[[610,2024],[1732,2024],[1732,2073],[610,2073]],"region":{"top_left_x":610,"top_left_y":2023,"width":1122,"height":51},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46a1e77fcc764599b36c547ae93084f2","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["a6b7e90c17dd43c0b06abafa6444506f","4e884ce61261414fb1e4cb0aa340e0aa"],"text":"","text_display":""},{"cnt":[[610,2028],[1132,2028],[1132,2069],[610,2069]],"region":{"top_left_x":610,"top_left_y":2028,"width":523,"height":41},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6b7e90c17dd43c0b06abafa6444506f","type":"table_of_contents_item","conversion_output":true,"parent_id":"46a1e77fcc764599b36c547ae93084f2","text":"4.5.2 Ambulatory Performance","text_display":"\n4.5.2 Ambulatory Performance","confidence":0.99951171875,"confidence_rate":0.9999852000944255},{"cnt":[[1684,2028],[1732,2028],[1732,2073],[1684,2073]],"region":{"top_left_x":1684,"top_left_y":2028,"width":48,"height":46},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e884ce61261414fb1e4cb0aa340e0aa","type":"table_of_contents_number","conversion_output":true,"parent_id":"46a1e77fcc764599b36c547ae93084f2","text":"23","text_display":" ..... 23","confidence":1,"confidence_rate":1},{"cnt":[[610,2075],[1732,2075],[1732,2121],[610,2121]],"region":{"top_left_x":610,"top_left_y":2075,"width":1122,"height":46},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd2b2ad174d94bcf84cbfa7b794e7d95","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["c5134c1cebd04b52a5b6284ab41b4ca5","068a0a96d837433da7148ed1e997f8cc"],"text":"","text_display":""},{"cnt":[[610,2075],[1177,2075],[1177,2116],[610,2116]],"region":{"top_left_x":610,"top_left_y":2075,"width":568,"height":42},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5134c1cebd04b52a5b6284ab41b4ca5","type":"table_of_contents_item","conversion_output":true,"parent_id":"cd2b2ad174d94bcf84cbfa7b794e7d95","text":"4.5.3 Patient Reported Outcomes","text_display":"\n4.5.3 Patient Reported Outcomes","confidence":0.9990234375,"confidence_rate":0.9999728603780688},{"cnt":[[1684,2075],[1732,2075],[1732,2114],[1684,2114]],"region":{"top_left_x":1684,"top_left_y":2075,"width":48,"height":40},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"068a0a96d837433da7148ed1e997f8cc","type":"table_of_contents_number","conversion_output":true,"parent_id":"cd2b2ad174d94bcf84cbfa7b794e7d95","text":"23","text_display":" ..... 23","confidence":1,"confidence_rate":1},{"cnt":[[503,2123],[1732,2123],[1732,2170],[503,2170]],"region":{"top_left_x":502,"top_left_y":2122,"width":1230,"height":48},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"071f83b81d3e4581817f859ac3b8990b","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["f1c406f631b1439eb4647bc3ecbcfec2","1bc68a6c58124863b9d2a8c3079f2824"],"text":"","text_display":""},{"cnt":[[507,2127],[866,2127],[866,2168],[507,2168]],"region":{"top_left_x":507,"top_left_y":2126,"width":359,"height":42},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1c406f631b1439eb4647bc3ecbcfec2","type":"table_of_contents_item","conversion_output":true,"parent_id":"071f83b81d3e4581817f859ac3b8990b","text":"4.6 Safety Analyses","text_display":"\n4.6 Safety Analyses","confidence":0.99951171875,"confidence_rate":0.9999796501863057},{"cnt":[[1684,2127],[1732,2127],[1732,2161],[1684,2161]],"region":{"top_left_x":1684,"top_left_y":2126,"width":48,"height":36},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bc68a6c58124863b9d2a8c3079f2824","type":"table_of_contents_number","conversion_output":true,"parent_id":"071f83b81d3e4581817f859ac3b8990b","text":"25","text_display":" ..... 25","confidence":1,"confidence_rate":1},{"cnt":[[610,2174],[1732,2174],[1732,2219],[610,2219]],"region":{"top_left_x":610,"top_left_y":2174,"width":1122,"height":46},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef808359965c4880a8ad041a6deab96f","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["ebd4351284cc441880d2ae2feaa757bb","96a6f98a21884332b6f58f67692e7113"],"text":"","text_display":""},{"cnt":[[612,2174],[1210,2174],[1210,2215],[612,2215]],"region":{"top_left_x":612,"top_left_y":2174,"width":598,"height":42},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebd4351284cc441880d2ae2feaa757bb","type":"table_of_contents_item","conversion_output":true,"parent_id":"ef808359965c4880a8ad041a6deab96f","text":"4.6.1 Exposure to Study Medication","text_display":"\n4.6.1 Exposure to Study Medication","confidence":1,"confidence_rate":1},{"cnt":[[1687,2174],[1732,2174],[1732,2213],[1687,2213]],"region":{"top_left_x":1686,"top_left_y":2174,"width":46,"height":39},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96a6f98a21884332b6f58f67692e7113","type":"table_of_contents_number","conversion_output":true,"parent_id":"ef808359965c4880a8ad041a6deab96f","text":"25","text_display":" ..... 25","confidence":1,"confidence_rate":1},{"cnt":[[610,2221],[1732,2221],[1732,2262],[610,2262]],"region":{"top_left_x":610,"top_left_y":2221,"width":1122,"height":42},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b881b8ae5ea04e35851e8ddbb0ea8c19","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["35378627657b4911b6fd72eabc2f0b84","cb9a34d77fc44082ac034db3825519d5"],"text":"","text_display":""},{"cnt":[[612,2226],[990,2226],[990,2258],[612,2258]],"region":{"top_left_x":612,"top_left_y":2225,"width":379,"height":34},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35378627657b4911b6fd72eabc2f0b84","type":"table_of_contents_item","conversion_output":true,"parent_id":"b881b8ae5ea04e35851e8ddbb0ea8c19","text":"4.6.2 Adverse Events","text_display":"\n4.6.2 Adverse Events","confidence":1,"confidence_rate":1},{"cnt":[[1684,2226],[1732,2226],[1732,2264],[1684,2264]],"region":{"top_left_x":1684,"top_left_y":2225,"width":48,"height":40},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb9a34d77fc44082ac034db3825519d5","type":"table_of_contents_number","conversion_output":true,"parent_id":"b881b8ae5ea04e35851e8ddbb0ea8c19","text":"26","text_display":" ..... 26","confidence":1,"confidence_rate":1},{"cnt":[[610,2271],[1734,2271],[1734,2318],[610,2318]],"region":{"top_left_x":610,"top_left_y":2270,"width":1124,"height":49},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"beecb4c8c87d4150a97928e336f23d5f","type":"table_of_contents_row","conversion_output":false,"parent_id":"16f4851c02a84330bc7bd2cb5a02af68","children_ids":["34adaf62ed17468eb1343d8f9829e1a4","5c5f9cd0a0714882a63b98b6e853acc3"],"text":"","text_display":""},{"cnt":[[612,2273],[965,2273],[965,2314],[612,2314]],"region":{"top_left_x":612,"top_left_y":2273,"width":353,"height":41},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34adaf62ed17468eb1343d8f9829e1a4","type":"table_of_contents_item","conversion_output":true,"parent_id":"beecb4c8c87d4150a97928e336f23d5f","text":"4.6.3 Neuroimaging","text_display":"\n4.6.3 Neuroimaging","confidence":1,"confidence_rate":1},{"cnt":[[1684,2273],[1732,2273],[1732,2316],[1684,2316]],"region":{"top_left_x":1684,"top_left_y":2273,"width":48,"height":44},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c5f9cd0a0714882a63b98b6e853acc3","type":"table_of_contents_number","conversion_output":true,"parent_id":"beecb4c8c87d4150a97928e336f23d5f","text":"27","text_display":" ..... 27","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1205,2368],[1205,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":773,"height":42},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2433a1893e13463a887f0ffa4a7a2389","type":"table_of_contents_row","conversion_output":false,"children_ids":["9a9f977260134a6a9ae3b1c143247c53"],"text":"","text_display":""},{"cnt":[[434,2368],[1201,2368],[1201,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":38},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a9f977260134a6a9ae3b1c143247c53","type":"table_of_contents_item","conversion_output":true,"parent_id":"2433a1893e13463a887f0ffa4a7a2389","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[587,2402],[587,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2401,"width":154,"height":34},"line":111,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a91af1c33eda4ce5bbb2ef2cf6c37610","type":"page_info","conversion_output":false,"text":"2/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":34},"line":112,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"88f99f1d9c784202a8b1ea3aa9930cd4","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"378534b48a6f4edda17cd06728808a43","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9926893626123956,"confidence_rate":0.9998871218934369},{"cnt":[[374,2608],[694,2608],[694,2643],[374,2643]],"region":{"top_left_x":373,"top_left_y":2608,"width":321,"height":35},"line":114,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f34c95e9832423d85a35f3f062c5f02","type":"page_info","conversion_output":false,"text":"763/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-04","page":4,"lines":[{"cnt":[[829,455],[1347,455],[1347,501],[829,501]],"region":{"top_left_x":829,"top_left_y":455,"width":519,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fdf1093808a44181b14ea9c8660a2060","type":"section_header","conversion_output":false,"children_ids":["8a1bef30b550453e8d8fb38cc245f338"],"text":"","text_display":""},{"cnt":[[829,458],[1343,458],[1343,496],[829,496]],"region":{"top_left_x":829,"top_left_y":457,"width":514,"height":40},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a1bef30b550453e8d8fb38cc245f338","type":"text","conversion_output":true,"parent_id":"fdf1093808a44181b14ea9c8660a2060","text":"TABLE OF CONTENTS (cont'd)","text_display":"\n\n\\section*{TABLE OF CONTENTS (cont'd)}","confidence":0.99658203125,"confidence_rate":0.9998895601844238},{"cnt":[[425,518],[1749,518],[1749,1540],[425,1540]],"region":{"top_left_x":425,"top_left_y":517,"width":1324,"height":1024},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60beae943bbd4afaab85555943d8607f","type":"table_of_contents_container","conversion_output":false,"children_ids":["4ec3440c203a49b59b96936013a339c4","ee9fe474714840309fa8450d9a14beaa","fd65dcd9421a44a69012149e7e3267d2","08180175a6954f819db4916188ecec7d","357cddb4398b4cf2a1243d56c2a2c55e","d957cb82e52d45a4b1dde1e5ff49e6d3","52316148676a401ba4c9fa42f432c671","8c377fd02140430ebebbfe12dd7bee7b","f5fca969a0444937becd77d6a0610c25","be0589c14f32484aad27833022c34d11","b245b6adcb654fd5a6bc13e1e64c0245","993949b5258c4719a08845a238b5f75f","9b9193384fb64858b7f98443a8cc64e9","7183b90243d74c73a9436e86aa977830","bfe1db2944c24066ab84ea81f89dfefa","6a7a0d12fbbc4567a9c77d2f96b483ad","deea1ddba3864113ba03c021575cc629"],"text":"","text_display":""},{"cnt":[[1652,524],[1742,524],[1742,569],[1652,569]],"region":{"top_left_x":1652,"top_left_y":524,"width":91,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ec3440c203a49b59b96936013a339c4","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["a9705321b8ea4ac79ffd0899745ce733"],"text":"","text_display":""},{"cnt":[[1654,526],[1742,526],[1742,565],[1654,565]],"region":{"top_left_x":1654,"top_left_y":526,"width":89,"height":40},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9705321b8ea4ac79ffd0899745ce733","type":"table_of_contents_item","conversion_output":true,"parent_id":"4ec3440c203a49b59b96936013a339c4","text":"Page","text_display":"\nPage","confidence":1,"confidence_rate":1},{"cnt":[[610,597],[1732,597],[1732,647],[610,647]],"region":{"top_left_x":610,"top_left_y":597,"width":1122,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee9fe474714840309fa8450d9a14beaa","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["00eaaf33c682484bad86b8a73a1bf2e3","98f6738149c744cb8c6549d4b2300b4e"],"text":"","text_display":""},{"cnt":[[610,602],[999,602],[999,642],[610,642]],"region":{"top_left_x":610,"top_left_y":601,"width":390,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00eaaf33c682484bad86b8a73a1bf2e3","type":"table_of_contents_item","conversion_output":true,"parent_id":"ee9fe474714840309fa8450d9a14beaa","text":"4.6.4 Laboratory Data","text_display":"\n4.6.4 Laboratory Data","confidence":0.966796875,"confidence_rate":0.9987021174993167},{"cnt":[[1684,602],[1732,602],[1732,636],[1684,636]],"region":{"top_left_x":1684,"top_left_y":601,"width":48,"height":35},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98f6738149c744cb8c6549d4b2300b4e","type":"table_of_contents_number","conversion_output":true,"parent_id":"ee9fe474714840309fa8450d9a14beaa","text":"29","text_display":" ..... 29","confidence":1,"confidence_rate":1},{"cnt":[[610,649],[1729,649],[1729,694],[610,694]],"region":{"top_left_x":610,"top_left_y":648,"width":1120,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd65dcd9421a44a69012149e7e3267d2","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["b0688c4f0af64e2ca94ee2f1aec6eff1","790523feff0f4464a39f196e9704e8b1"],"text":"","text_display":""},{"cnt":[[612,653],[913,653],[913,694],[612,694]],"region":{"top_left_x":612,"top_left_y":653,"width":302,"height":41},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0688c4f0af64e2ca94ee2f1aec6eff1","type":"table_of_contents_item","conversion_output":true,"parent_id":"fd65dcd9421a44a69012149e7e3267d2","text":"4.6.5 Vital Signs","text_display":"\n4.6.5 Vital Signs","confidence":0.99609375,"confidence_rate":0.9998221113094726},{"cnt":[[1687,653],[1732,653],[1732,688],[1687,688]],"region":{"top_left_x":1686,"top_left_y":653,"width":46,"height":35},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"790523feff0f4464a39f196e9704e8b1","type":"table_of_contents_number","conversion_output":true,"parent_id":"fd65dcd9421a44a69012149e7e3267d2","text":"30","text_display":" ..... 30","confidence":1,"confidence_rate":1},{"cnt":[[610,698],[1729,698],[1729,743],[610,743]],"region":{"top_left_x":610,"top_left_y":698,"width":1120,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08180175a6954f819db4916188ecec7d","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["0946d4a6e30b4d499f565152b70e2165","88e74b2186c1447c9bce5461399f0c24"],"text":"","text_display":""},{"cnt":[[610,700],[879,700],[879,741],[610,741]],"region":{"top_left_x":610,"top_left_y":700,"width":269,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0946d4a6e30b4d499f565152b70e2165","type":"table_of_contents_item","conversion_output":true,"parent_id":"08180175a6954f819db4916188ecec7d","text":"4.6.6 Mortality","text_display":"\n4.6.6 Mortality","confidence":0.9990236759185791,"confidence_rate":0.9999511611428449},{"cnt":[[1687,692],[1732,692],[1732,735],[1687,735]],"region":{"top_left_x":1686,"top_left_y":691,"width":46,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88e74b2186c1447c9bce5461399f0c24","type":"table_of_contents_number","conversion_output":true,"parent_id":"08180175a6954f819db4916188ecec7d","text":"30","text_display":" ..... 30","confidence":1,"confidence_rate":1},{"cnt":[[610,748],[1729,748],[1729,788],[610,788]],"region":{"top_left_x":610,"top_left_y":747,"width":1120,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"357cddb4398b4cf2a1243d56c2a2c55e","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["26e90bcf0a8d45da9d1d7a38e3e954f2","078ea92229294255b4bc39a879d06f81"],"text":"","text_display":""},{"cnt":[[610,750],[1351,750],[1351,784],[610,784]],"region":{"top_left_x":610,"top_left_y":749,"width":742,"height":36},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26e90bcf0a8d45da9d1d7a38e3e954f2","type":"table_of_contents_item","conversion_output":true,"parent_id":"357cddb4398b4cf2a1243d56c2a2c55e","text":"4.6.7 Previous and Concomitant Medications","text_display":"\n4.6.7 Previous and Concomitant Medications","confidence":1,"confidence_rate":1},{"cnt":[[1687,743],[1732,743],[1732,786],[1687,786]],"region":{"top_left_x":1686,"top_left_y":743,"width":46,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"078ea92229294255b4bc39a879d06f81","type":"table_of_contents_number","conversion_output":true,"parent_id":"357cddb4398b4cf2a1243d56c2a2c55e","text":"30","text_display":" ..... 30","confidence":1,"confidence_rate":1},{"cnt":[[503,795],[1732,795],[1732,879],[503,879]],"region":{"top_left_x":502,"top_left_y":794,"width":1230,"height":85},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d957cb82e52d45a4b1dde1e5ff49e6d3","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["29a59b07e2ce43aeb2747c91ec43ee2c","0ff970e22e2a4e8ea60380d49e3928e6","2448e3552898424d8d23f287e8b787e8"],"text":"","text_display":""},{"cnt":[[507,799],[1394,799],[1394,840],[507,840]],"region":{"top_left_x":507,"top_left_y":799,"width":888,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29a59b07e2ce43aeb2747c91ec43ee2c","type":"table_of_contents_item","conversion_output":true,"parent_id":"d957cb82e52d45a4b1dde1e5ff49e6d3","text":"4.7 Handling of Dropouts, Missing/Incomplete Data, or","text_display":"\n4.7 Handling of Dropouts, Missing/Incomplete Data, or","confidence":1,"confidence_rate":1},{"cnt":[[612,838],[737,838],[737,874],[612,874]],"region":{"top_left_x":612,"top_left_y":837,"width":125,"height":38},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ff970e22e2a4e8ea60380d49e3928e6","type":"table_of_contents_item","conversion_output":true,"parent_id":"d957cb82e52d45a4b1dde1e5ff49e6d3","text":"Outliers","text_display":" Outliers","confidence":1,"confidence_rate":1},{"cnt":[[1684,831],[1732,831],[1732,877],[1684,877]],"region":{"top_left_x":1684,"top_left_y":831,"width":48,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2448e3552898424d8d23f287e8b787e8","type":"table_of_contents_number","conversion_output":true,"parent_id":"d957cb82e52d45a4b1dde1e5ff49e6d3","text":"30","text_display":" ..... 30","confidence":1,"confidence_rate":1},{"cnt":[[503,885],[1729,885],[1729,930],[503,930]],"region":{"top_left_x":502,"top_left_y":885,"width":1228,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52316148676a401ba4c9fa42f432c671","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["dd83a4bbf7384cbf9eb7d4c44014fb00","1fcf76784cbd48b9ac9b2bf4c12db029"],"text":"","text_display":""},{"cnt":[[507,889],[1231,889],[1231,930],[507,930]],"region":{"top_left_x":507,"top_left_y":889,"width":725,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd83a4bbf7384cbf9eb7d4c44014fb00","type":"table_of_contents_item","conversion_output":true,"parent_id":"52316148676a401ba4c9fa42f432c671","text":"4.8 Interim Analyses and/or Safety Reviews","text_display":"\n4.8 Interim Analyses and/or Safety Reviews","confidence":1,"confidence_rate":1},{"cnt":[[1687,881],[1729,881],[1729,924],[1687,924]],"region":{"top_left_x":1686,"top_left_y":880,"width":44,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fcf76784cbd48b9ac9b2bf4c12db029","type":"table_of_contents_number","conversion_output":true,"parent_id":"52316148676a401ba4c9fa42f432c671","text":"31","text_display":" ..... 31","confidence":1,"confidence_rate":1},{"cnt":[[432,935],[1729,935],[1729,975],[432,975]],"region":{"top_left_x":431,"top_left_y":934,"width":1299,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c377fd02140430ebebbfe12dd7bee7b","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["f274a63fd59f4053a1899e7de068b642","665b19f201644ead948fa165a529986d"],"text":"","text_display":""},{"cnt":[[434,937],[750,937],[750,973],[434,973]],"region":{"top_left_x":433,"top_left_y":936,"width":317,"height":38},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f274a63fd59f4053a1899e7de068b642","type":"table_of_contents_item","conversion_output":true,"parent_id":"8c377fd02140430ebebbfe12dd7bee7b","text":"5. REFERENCES","text_display":"\n5. REFERENCES","confidence":1,"confidence_rate":1},{"cnt":[[1687,935],[1732,935],[1732,971],[1687,971]],"region":{"top_left_x":1686,"top_left_y":934,"width":46,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"665b19f201644ead948fa165a529986d","type":"table_of_contents_number","conversion_output":true,"parent_id":"8c377fd02140430ebebbfe12dd7bee7b","text":"31","text_display":" ..... 31","confidence":1,"confidence_rate":1},{"cnt":[[432,1031],[823,1031],[823,1068],[432,1068]],"region":{"top_left_x":431,"top_left_y":1031,"width":392,"height":37},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5fca969a0444937becd77d6a0610c25","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["de6cddfbef674abd971eb1f445044c56"],"text":"","text_display":""},{"cnt":[[434,1031],[819,1031],[819,1068],[434,1068]],"region":{"top_left_x":433,"top_left_y":1031,"width":386,"height":37},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de6cddfbef674abd971eb1f445044c56","type":"table_of_contents_item","conversion_output":true,"parent_id":"f5fca969a0444937becd77d6a0610c25","text":"TABLES AND FIGURES","text_display":"\nTABLES AND FIGURES","confidence":1,"confidence_rate":1},{"cnt":[[432,1079],[1732,1079],[1732,1128],[432,1128]],"region":{"top_left_x":431,"top_left_y":1078,"width":1301,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be0589c14f32484aad27833022c34d11","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["3c4c9baa3bc040589ed4b43a4ebf06a3","675e3c40846643ae97b7c778d7b86aee"],"text":"","text_display":""},{"cnt":[[434,1083],[1366,1083],[1366,1126],[434,1126]],"region":{"top_left_x":433,"top_left_y":1082,"width":934,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c4c9baa3bc040589ed4b43a4ebf06a3","type":"table_of_contents_item","conversion_output":true,"parent_id":"be0589c14f32484aad27833022c34d11","text":"Table 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )","text_display":"\nTable 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )","confidence":0.9057111740112305,"confidence_rate":0.9986442785033869},{"cnt":[[1706,1087],[1732,1087],[1732,1124],[1706,1124]],"region":{"top_left_x":1705,"top_left_y":1087,"width":27,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"675e3c40846643ae97b7c778d7b86aee","type":"table_of_contents_number","conversion_output":true,"parent_id":"be0589c14f32484aad27833022c34d11","text":"9","text_display":" ..... 9","confidence":1,"confidence_rate":1},{"cnt":[[434,1134],[1729,1134],[1729,1179],[434,1179]],"region":{"top_left_x":433,"top_left_y":1134,"width":1297,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b245b6adcb654fd5a6bc13e1e64c0245","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["b5dd03808d194d0eba47745b957c0c88","bb6802f95dfe498c863a2204c14a18b7"],"text":"","text_display":""},{"cnt":[[434,1137],[1038,1137],[1038,1177],[434,1177]],"region":{"top_left_x":433,"top_left_y":1136,"width":605,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5dd03808d194d0eba47745b957c0c88","type":"table_of_contents_item","conversion_output":true,"parent_id":"b245b6adcb654fd5a6bc13e1e64c0245","text":"Table 2 Summary of Efficacy Analyses","text_display":"\nTable 2 Summary of Efficacy Analyses","confidence":1,"confidence_rate":1},{"cnt":[[1684,1139],[1729,1139],[1729,1175],[1684,1175]],"region":{"top_left_x":1684,"top_left_y":1138,"width":46,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb6802f95dfe498c863a2204c14a18b7","type":"table_of_contents_number","conversion_output":true,"parent_id":"b245b6adcb654fd5a6bc13e1e64c0245","text":"21","text_display":" ..... 21","confidence":1,"confidence_rate":1},{"cnt":[[434,1186],[1729,1186],[1729,1231],[434,1231]],"region":{"top_left_x":433,"top_left_y":1185,"width":1297,"height":47},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"993949b5258c4719a08845a238b5f75f","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["3eddb6ed75d04bf0acd03ebf9104522e","884e46b9135047f1a6f767bfc47e08ba"],"text":"","text_display":""},{"cnt":[[434,1190],[930,1190],[930,1229],[434,1229]],"region":{"top_left_x":433,"top_left_y":1190,"width":498,"height":39},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3eddb6ed75d04bf0acd03ebf9104522e","type":"table_of_contents_item","conversion_output":true,"parent_id":"993949b5258c4719a08845a238b5f75f","text":"Table 3 Cognitive Assessments","text_display":"\nTable 3 Cognitive Assessments","confidence":1,"confidence_rate":1},{"cnt":[[1684,1190],[1732,1190],[1732,1227],[1684,1227]],"region":{"top_left_x":1684,"top_left_y":1190,"width":48,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"884e46b9135047f1a6f767bfc47e08ba","type":"table_of_contents_number","conversion_output":true,"parent_id":"993949b5258c4719a08845a238b5f75f","text":"22","text_display":" ..... 22","confidence":1,"confidence_rate":1},{"cnt":[[432,1238],[1729,1238],[1729,1283],[432,1283]],"region":{"top_left_x":431,"top_left_y":1237,"width":1299,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b9193384fb64858b7f98443a8cc64e9","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["982bffb976aa4b2bb8592e9dbb4080aa","8cd48aa5c55046e7ac043024b39c8161"],"text":"","text_display":""},{"cnt":[[434,1240],[1437,1240],[1437,1283],[434,1283]],"region":{"top_left_x":433,"top_left_y":1239,"width":1005,"height":44},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"982bffb976aa4b2bb8592e9dbb4080aa","type":"table_of_contents_item","conversion_output":true,"parent_id":"9b9193384fb64858b7f98443a8cc64e9","text":"Table 4 Intermediate Variables for the Next Allocation Probability","text_display":"\nTable 4 Intermediate Variables for the Next Allocation Probability","confidence":1,"confidence_rate":1},{"cnt":[[1684,1242],[1732,1242],[1732,1278],[1684,1278]],"region":{"top_left_x":1684,"top_left_y":1241,"width":48,"height":38},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cd48aa5c55046e7ac043024b39c8161","type":"table_of_contents_number","conversion_output":true,"parent_id":"9b9193384fb64858b7f98443a8cc64e9","text":"44","text_display":" ..... 44","confidence":1,"confidence_rate":1},{"cnt":[[432,1289],[1729,1289],[1729,1330],[432,1330]],"region":{"top_left_x":431,"top_left_y":1289,"width":1299,"height":41},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7183b90243d74c73a9436e86aa977830","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["ce5a929a4686413084e8d598f42ae30e","dbb4a6aa992644c9a7ba3f5918c32d01"],"text":"","text_display":""},{"cnt":[[434,1293],[1304,1293],[1304,1328],[434,1328]],"region":{"top_left_x":433,"top_left_y":1293,"width":872,"height":35},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce5a929a4686413084e8d598f42ae30e","type":"table_of_contents_item","conversion_output":true,"parent_id":"7183b90243d74c73a9436e86aa977830","text":"Table 5 Decisions Based on Site and Overall Imbalance","text_display":"\nTable 5 Decisions Based on Site and Overall Imbalance","confidence":0.99267578125,"confidence_rate":0.9998794962360626},{"cnt":[[1684,1293],[1732,1293],[1732,1330],[1684,1330]],"region":{"top_left_x":1684,"top_left_y":1293,"width":48,"height":37},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbb4a6aa992644c9a7ba3f5918c32d01","type":"table_of_contents_number","conversion_output":true,"parent_id":"7183b90243d74c73a9436e86aa977830","text":"44","text_display":" ..... 44","confidence":1,"confidence_rate":1},{"cnt":[[432,1341],[1732,1341],[1732,1381],[432,1381]],"region":{"top_left_x":431,"top_left_y":1340,"width":1301,"height":42},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfe1db2944c24066ab84ea81f89dfefa","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["0830b83842db4f67a6e38e0b3848dce3","ac2b66e9c3fa4ca9b151185b40248864"],"text":"","text_display":""},{"cnt":[[434,1345],[1412,1345],[1412,1381],[434,1381]],"region":{"top_left_x":433,"top_left_y":1344,"width":979,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0830b83842db4f67a6e38e0b3848dce3","type":"table_of_contents_item","conversion_output":true,"parent_id":"bfe1db2944c24066ab84ea81f89dfefa","text":"Table 6 Baseline Characteristics to be Evaluated for Imbalance","text_display":"\nTable 6 Baseline Characteristics to be Evaluated for Imbalance","confidence":0.9980475902557373,"confidence_rate":0.9999720815585754},{"cnt":[[1687,1345],[1732,1345],[1732,1381],[1687,1381]],"region":{"top_left_x":1686,"top_left_y":1344,"width":46,"height":38},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac2b66e9c3fa4ca9b151185b40248864","type":"table_of_contents_number","conversion_output":true,"parent_id":"bfe1db2944c24066ab84ea81f89dfefa","text":"50","text_display":" ..... 50","confidence":1,"confidence_rate":1},{"cnt":[[434,1437],[1732,1437],[1732,1482],[434,1482]],"region":{"top_left_x":433,"top_left_y":1437,"width":1299,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a7a0d12fbbc4567a9c77d2f96b483ad","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["0d57e5b66c5b4d9a9c3a5c574b3397aa","bd49ddc676fa49aaa575bf565e4ea744"],"text":"","text_display":""},{"cnt":[[434,1439],[836,1439],[836,1480],[434,1480]],"region":{"top_left_x":433,"top_left_y":1439,"width":403,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d57e5b66c5b4d9a9c3a5c574b3397aa","type":"table_of_contents_item","conversion_output":true,"parent_id":"6a7a0d12fbbc4567a9c77d2f96b483ad","text":"Figure 1 Study Flowchart","text_display":"\nFigure 1 Study Flowchart","confidence":1,"confidence_rate":1},{"cnt":[[1684,1435],[1732,1435],[1732,1474],[1684,1474]],"region":{"top_left_x":1684,"top_left_y":1435,"width":48,"height":39},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd49ddc676fa49aaa575bf565e4ea744","type":"table_of_contents_number","conversion_output":true,"parent_id":"6a7a0d12fbbc4567a9c77d2f96b483ad","text":"42","text_display":" ..... 42","confidence":1,"confidence_rate":1},{"cnt":[[434,1491],[1732,1491],[1732,1536],[434,1536]],"region":{"top_left_x":433,"top_left_y":1491,"width":1299,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"deea1ddba3864113ba03c021575cc629","type":"table_of_contents_row","conversion_output":false,"parent_id":"60beae943bbd4afaab85555943d8607f","children_ids":["a964095be7c740739911d342ae8d0476","7d40aba5e69c47bc893b922d752bf385"],"text":"","text_display":""},{"cnt":[[434,1491],[1051,1491],[1051,1532],[434,1532]],"region":{"top_left_x":433,"top_left_y":1491,"width":618,"height":41},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a964095be7c740739911d342ae8d0476","type":"table_of_contents_item","conversion_output":true,"parent_id":"deea1ddba3864113ba03c021575cc629","text":"Figure 2 Study Randomization Schema","text_display":"\nFigure 2 Study Randomization Schema","confidence":1,"confidence_rate":1},{"cnt":[[1684,1487],[1732,1487],[1732,1528],[1684,1528]],"region":{"top_left_x":1684,"top_left_y":1486,"width":48,"height":42},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d40aba5e69c47bc893b922d752bf385","type":"table_of_contents_number","conversion_output":true,"parent_id":"deea1ddba3864113ba03c021575cc629","text":"45","text_display":" ..... 45","confidence":1,"confidence_rate":1},{"cnt":[[434,2372],[1201,2372],[1201,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2371,"width":768,"height":34},"line":54,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"afd4236af12b45f29a6891a064ee0ff2","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":0.9985356330871582,"confidence_rate":0.9999738317683595},{"cnt":[[434,2406],[582,2406],[582,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2406,"width":150,"height":29},"line":55,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"af84db021ce74517b344a46f8c0e50e3","type":"page_info","conversion_output":false,"text":"3/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1048,2406],[1179,2406],[1179,2434],[1048,2434]],"region":{"top_left_x":1048,"top_left_y":2406,"width":132,"height":29},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5c6e11a640954b1a928c137ea219375c","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fb62186c9534e3fa31f453b2242a556","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9960987546946853,"confidence_rate":0.9999398652695066},{"cnt":[[374,2608],[692,2608],[692,2640],[374,2640]],"region":{"top_left_x":373,"top_left_y":2608,"width":319,"height":33},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d30c6a4458ac4211b47056a50b468263","type":"page_info","conversion_output":false,"text":"764/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-05","page":5,"lines":[{"cnt":[[827,451],[1347,451],[1347,501],[827,501]],"region":{"top_left_x":827,"top_left_y":451,"width":521,"height":50},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0407b663ea084f44b68fd232d9525bb4","type":"section_header","conversion_output":false,"children_ids":["3b133fd39dcb453a9e8f0ff34e1f30d9"],"text":"","text_display":""},{"cnt":[[829,455],[1343,455],[1343,498],[829,498]],"region":{"top_left_x":829,"top_left_y":455,"width":514,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b133fd39dcb453a9e8f0ff34e1f30d9","type":"text","conversion_output":true,"parent_id":"0407b663ea084f44b68fd232d9525bb4","text":"TABLE OF CONTENTS (cont'd)","text_display":"\n\n\\section*{TABLE OF CONTENTS (cont'd)}","confidence":0.9990234375,"confidence_rate":0.9999684830886739},{"cnt":[[1654,524],[1742,524],[1742,565],[1654,565]],"region":{"top_left_x":1654,"top_left_y":524,"width":89,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db5c6598cd094fa192b1ad1c6a55d635","type":"text","conversion_output":true,"text":"Page","text_display":"\n\nPage","confidence":1,"confidence_rate":1},{"cnt":[[430,597],[668,597],[668,638],[430,638]],"region":{"top_left_x":429,"top_left_y":597,"width":240,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4af65ac869a433a9e1ec642cc8da34c","type":"section_header","conversion_output":false,"children_ids":["0d90a3e1f247432f83e83a493c4f2b35"],"text":"","text_display":""},{"cnt":[[434,602],[664,602],[664,638],[434,638]],"region":{"top_left_x":433,"top_left_y":601,"width":231,"height":38},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d90a3e1f247432f83e83a493c4f2b35","type":"text","conversion_output":true,"parent_id":"c4af65ac869a433a9e1ec642cc8da34c","text":"APPENDICES","text_display":"\n\n\\section*{APPENDICES}","confidence":1,"confidence_rate":1},{"cnt":[[434,653],[904,653],[904,694],[434,694]],"region":{"top_left_x":433,"top_left_y":653,"width":472,"height":41},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3a5089f292b4fe2bfb99e6ca12076ea","type":"text","conversion_output":true,"text":"Appendix A Protocol Synopsis","text_display":"\n\nAppendix A Protocol Synopsis","confidence":1,"confidence_rate":1},{"cnt":[[434,705],[1356,705],[1356,748],[434,748]],"region":{"top_left_x":433,"top_left_y":704,"width":923,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"361bf7ea55954778ab616855d049cdf9","type":"text","conversion_output":true,"text":"Appendix B Schedule of Assessment and Study Flow Chart","text_display":"\nAppendix B Schedule of Assessment and Study Flow Chart","confidence":1,"confidence_rate":1},{"cnt":[[434,758],[999,758],[999,801],[434,801]],"region":{"top_left_x":433,"top_left_y":758,"width":567,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19481eb794e94fe29964da726bf346df","type":"text","conversion_output":true,"text":"Appendix C Randomization Scheme","text_display":"\nAppendix C Randomization Scheme","confidence":1,"confidence_rate":1},{"cnt":[[434,810],[1171,810],[1171,853],[434,853]],"region":{"top_left_x":433,"top_left_y":809,"width":738,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cf3985b630640558d0041137557e4ec","type":"text","conversion_output":true,"text":"Appendix D Statistical Methods Requiring Input","text_display":"\nAppendix D Statistical Methods Requiring Input","confidence":0.99951171875,"confidence_rate":0.9999904235654993},{"cnt":[[434,862],[1467,862],[1467,904],[434,904]],"region":{"top_left_x":433,"top_left_y":861,"width":1035,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57880fdea61447b8a958386d2a9c3752","type":"text","conversion_output":true,"text":"Appendix E Documentation of Additional Analyses Performed after","text_display":"\nAppendix E Documentation of Additional Analyses Performed after","confidence":1,"confidence_rate":1},{"cnt":[[645,907],[883,907],[883,943],[645,943]],"region":{"top_left_x":644,"top_left_y":906,"width":240,"height":38},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aeb24d1669ce4e3b98f9521358ff8758","type":"text","conversion_output":true,"text":"Database Lock","text_display":" Database Lock","confidence":1,"confidence_rate":1},{"cnt":[[434,954],[947,954],[947,999],[434,999]],"region":{"top_left_x":433,"top_left_y":953,"width":515,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30ea4988dd494bb49d8e319acd2d18e2","type":"text","conversion_output":true,"text":"Appendix F Data Handling Rules","text_display":"\nAppendix F Data Handling Rules","confidence":1,"confidence_rate":1},{"cnt":[[434,1010],[1298,1010],[1298,1051],[434,1051]],"region":{"top_left_x":433,"top_left_y":1009,"width":865,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79717187b9a54ccb8a337e0051416083","type":"text","conversion_output":true,"text":"Appendix G Programming Codes for Statistical Analysis","text_display":"\nAppendix G Programming Codes for Statistical Analysis","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1201,2368],[1201,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":42},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5bb3a6860bdd419a95a3a9d17b0a6b24","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[587,2402],[587,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2401,"width":154,"height":34},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f43eee4805c04425a5e124a6e58a8506","type":"page_info","conversion_output":false,"text":"4/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":34},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cad6b081b35e46c48a10b633a4bb0716","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e0b70960e254c578ced4c0ba0f40073","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936599708162248,"confidence_rate":0.9999021553636731},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7631223e84ac46cf9b24b4a834025b60","type":"page_info","conversion_output":false,"text":"765/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-06","page":6,"lines":[{"cnt":[[352,451],[698,451],[698,494],[352,494]],"region":{"top_left_x":352,"top_left_y":451,"width":347,"height":44},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62cf2cbccce4454bb6d3b199785daaed","type":"section_header","conversion_output":false,"children_ids":["4ee98ab9aeb3475a8d800d827be44edd"],"text":"","text_display":""},{"cnt":[[354,455],[694,455],[694,492],[354,492]],"region":{"top_left_x":354,"top_left_y":455,"width":340,"height":37},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ee98ab9aeb3475a8d800d827be44edd","type":"text","conversion_output":true,"parent_id":"62cf2cbccce4454bb6d3b199785daaed","text":"1. BACKGROUND","text_display":"\n\n\\section*{1. BACKGROUND}","confidence":1,"confidence_rate":1},{"cnt":[[434,524],[1687,524],[1687,565],[434,565]],"region":{"top_left_x":433,"top_left_y":524,"width":1254,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55e317e75aba40ad810615f637a3ba39","type":"text","conversion_output":true,"text":"Stroke is the fourth leading cause of death and a leading cause of disability in the","text_display":"\n\nStroke is the fourth leading cause of death and a leading cause of disability in the","confidence":1,"confidence_rate":1},{"cnt":[[434,576],[1734,576],[1734,617],[434,617]],"region":{"top_left_x":433,"top_left_y":575,"width":1301,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aab6bc531b54c309f5e9b1228e6b5af","type":"text","conversion_output":true,"text":"United States (U.S.). More than half of all ischemic stroke patients have mild strokes","text_display":" United States (U.S.). More than half of all ischemic stroke patients have mild strokes","confidence":1,"confidence_rate":1},{"cnt":[[434,670],[434,626],[1631,628],[1631,672]],"region":{"top_left_x":433,"top_left_y":625,"width":1198,"height":48},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f968c7b20a949e28983fc1a00618eb2","type":"text","conversion_output":true,"text":"at initial presentation in population-based studies ( \\(3 ; 10\\) ). Alteplase is the only","text_display":" at initial presentation in population-based studies ( \\(3 ; 10\\) ). Alteplase is the only","confidence":0.9713907879023509,"confidence_rate":0.9996810790810795},{"cnt":[[434,681],[1699,681],[1699,724],[434,724]],"region":{"top_left_x":433,"top_left_y":681,"width":1267,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ad387d8db1a4b5f9b3db68995e8e9e3","type":"text","conversion_output":true,"text":"approved therapeutic agent for the treatment of AIS (acute ischemic stroke) and is","text_display":" approved therapeutic agent for the treatment of AIS (acute ischemic stroke) and is","confidence":1,"confidence_rate":1},{"cnt":[[434,733],[1665,733],[1665,776],[434,776]],"region":{"top_left_x":433,"top_left_y":732,"width":1233,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"589c075e47ae4d5592941e4f311997c0","type":"text","conversion_output":true,"text":"widely accepted as the standard of care for eligible patients ( \\(4 ; 6\\) ). The currently","text_display":" widely accepted as the standard of care for eligible patients ( \\(4 ; 6\\) ). The currently","confidence":0.9422450065612793,"confidence_rate":0.999353579168583},{"cnt":[[434,778],[1687,778],[1687,827],[434,827]],"region":{"top_left_x":433,"top_left_y":777,"width":1254,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab1d75a7236c4f66901234ae255c82cf","type":"text","conversion_output":true,"text":"approved Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI) contains wording that","text_display":" approved Activase \\({ }^{\\text {® }}\\) (alteplase) U.S. Package Insert (USPI) contains wording that","confidence":0.6585359573364258,"confidence_rate":0.9958313514942605},{"cnt":[[434,838],[1704,838],[1704,879],[434,879]],"region":{"top_left_x":433,"top_left_y":837,"width":1271,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55cd2e7be05c4da29593164ed7c9330c","type":"text","conversion_output":true,"text":"recommends against use of alteplase in patients with \"minor neurological deficit or","text_display":" recommends against use of alteplase in patients with \"minor neurological deficit or","confidence":1,"confidence_rate":1},{"cnt":[[434,889],[1699,889],[1699,930],[434,930]],"region":{"top_left_x":433,"top_left_y":889,"width":1267,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2838a59969c44f29b8faf78b90e29736","type":"text","conversion_output":true,"text":"with rapidly improving stroke symptoms\" due to the fact this patient population has","text_display":" with rapidly improving stroke symptoms\" due to the fact this patient population has","confidence":1,"confidence_rate":1},{"cnt":[[434,941],[1725,941],[1725,982],[434,982]],"region":{"top_left_x":433,"top_left_y":941,"width":1293,"height":41},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"482fd250115441e39ff132bde60e1338","type":"text","conversion_output":true,"text":"not been evaluated. Furthermore, the current American Heart Association/American","text_display":" not been evaluated. Furthermore, the current American Heart Association/American","confidence":1,"confidence_rate":1},{"cnt":[[434,993],[1697,993],[1697,1033],[434,1033]],"region":{"top_left_x":433,"top_left_y":992,"width":1265,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da25c46fd1d2413488ac9d4f710d2312","type":"text","conversion_output":true,"text":"Stroke Association Council Guidelines include \"minor and rapidly improving stroke","text_display":" Stroke Association Council Guidelines include \"minor and rapidly improving stroke","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[434,1044],[1680,1044],[1680,1085],[434,1085]],"region":{"top_left_x":433,"top_left_y":1044,"width":1248,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4f30d09d39441df8e94c3796306649c","type":"text","conversion_output":true,"text":"symptoms (clearing spontaneously)\" as a relative exclusion criterion for alteplase","text_display":" symptoms (clearing spontaneously)\" as a relative exclusion criterion for alteplase","confidence":1,"confidence_rate":1},{"cnt":[[434,1096],[1639,1096],[1639,1139],[434,1139]],"region":{"top_left_x":433,"top_left_y":1095,"width":1207,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38fa9a15040647e5b9b0df8561ae2ffd","type":"text","conversion_output":true,"text":"(6). This is largely due to the aforementioned label wording not recommending","text_display":" (6). This is largely due to the aforementioned label wording not recommending","confidence":1,"confidence_rate":1},{"cnt":[[434,1147],[1708,1147],[1708,1190],[434,1190]],"region":{"top_left_x":433,"top_left_y":1147,"width":1276,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a15c47c12520481280a9f140d27726b9","type":"text","conversion_output":true,"text":"treatment of patients with minor neurological deficit or with rapidly improving stroke","text_display":" treatment of patients with minor neurological deficit or with rapidly improving stroke","confidence":1,"confidence_rate":1},{"cnt":[[434,1199],[1588,1199],[1588,1244],[434,1244]],"region":{"top_left_x":433,"top_left_y":1198,"width":1155,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a43dfa888b124a899f80fadc7b56e811","type":"text","conversion_output":true,"text":"symptoms (RISS), the lack of a consistent and consensus definition of who","text_display":" symptoms (RISS), the lack of a consistent and consensus definition of who","confidence":1,"confidence_rate":1},{"cnt":[[434,1250],[1605,1250],[1605,1293],[434,1293]],"region":{"top_left_x":433,"top_left_y":1250,"width":1172,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe72599748674451b3b3dbe8756c7e09","type":"text","conversion_output":true,"text":"constitutes this patient population, and the absence of definitive evidence of","text_display":" constitutes this patient population, and the absence of definitive evidence of","confidence":1,"confidence_rate":1},{"cnt":[[434,1302],[1678,1302],[1678,1347],[434,1347]],"region":{"top_left_x":433,"top_left_y":1301,"width":1245,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"236e37cfd0144fcda987bcd18b2a3ffb","type":"text","conversion_output":true,"text":"alteplase efficacy in this setting (TREAT Task Force 2013). Therefore, this trial is","text_display":" alteplase efficacy in this setting (TREAT Task Force 2013). Therefore, this trial is","confidence":0.9990234375,"confidence_rate":0.9999890220866866},{"cnt":[[434,1358],[1699,1358],[1699,1399],[434,1399]],"region":{"top_left_x":433,"top_left_y":1357,"width":1267,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ddfbc954a044fd49e68488fa9fcf822","type":"text","conversion_output":true,"text":"designed to evaluate the efficacy and safety of alteplase in confirmed AIS patients","text_display":" designed to evaluate the efficacy and safety of alteplase in confirmed AIS patients","confidence":1,"confidence_rate":1},{"cnt":[[434,1409],[1704,1409],[1704,1450],[434,1450]],"region":{"top_left_x":433,"top_left_y":1409,"width":1271,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"152b6f6efd0d42b88bbda21e209aac08","type":"text","conversion_output":true,"text":"with minor neurological deficit or with RISS, which will be referred to collectively as","text_display":" with minor neurological deficit or with RISS, which will be referred to collectively as","confidence":1,"confidence_rate":1},{"cnt":[[434,1461],[638,1461],[638,1497],[434,1497]],"region":{"top_left_x":433,"top_left_y":1460,"width":206,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fff0e035001f40c19ff76a748a064f31","type":"text","conversion_output":true,"text":"\"mild stroke\".","text_display":" \"mild stroke\".","confidence":1,"confidence_rate":1},{"cnt":[[434,1551],[1433,1551],[1433,1594],[434,1594]],"region":{"top_left_x":433,"top_left_y":1551,"width":1001,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"735a78331bcf4501b7946783cf335ca8","type":"text","conversion_output":true,"text":"For further background information see Section 1 of the protocol.","text_display":"\n\nFor further background information see Section 1 of the protocol.","confidence":0.99951171875,"confidence_rate":0.9999933096045984},{"cnt":[[434,1646],[1712,1646],[1712,1687],[434,1687]],"region":{"top_left_x":433,"top_left_y":1645,"width":1280,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb9a1714aa114fe69e977bbf856a3552","type":"text","conversion_output":true,"text":"The original plan was for approximately 948 patients with mild stroke to be enrolled","text_display":"\n\nThe original plan was for approximately 948 patients with mild stroke to be enrolled","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,1697],[1571,1697],[1571,1742],[434,1742]],"region":{"top_left_x":433,"top_left_y":1697,"width":1138,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d14c2d862704586a9f14f62975356e8","type":"text","conversion_output":true,"text":"and randomized in a 1:1 ratio to two treatment groups. However the study","text_display":" and randomized in a 1:1 ratio to two treatment groups. However the study","confidence":0.9970703125,"confidence_rate":0.9999618969930187},{"cnt":[[434,1749],[1738,1749],[1738,1794],[434,1794]],"region":{"top_left_x":433,"top_left_y":1748,"width":1306,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8855dc9ad89d46468de046ba251b9acb","type":"text","conversion_output":true,"text":"enrollment was prematurely terminated due to recruitment below target in December","text_display":" enrollment was prematurely terminated due to recruitment below target in December","confidence":1,"confidence_rate":1},{"cnt":[[434,1800],[1695,1800],[1695,1846],[434,1846]],"region":{"top_left_x":433,"top_left_y":1800,"width":1263,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dad27f3f0d6a4f838c2ceed8b0056b4b","type":"text","conversion_output":true,"text":"2016 (at approximately \\(1 / 3\\) of original planned enrollment of 948 ) and the analysis","text_display":" 2016 (at approximately \\(1 / 3\\) of original planned enrollment of 948 ) and the analysis","confidence":0.9555878639221191,"confidence_rate":0.9995116401083896},{"cnt":[[434,1852],[1635,1852],[1635,1897],[434,1897]],"region":{"top_left_x":433,"top_left_y":1851,"width":1202,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f1ff278273d47fda15a939eea9f90d9","type":"text","conversion_output":true,"text":"will be performed using available data from patients randomized prior to study","text_display":" will be performed using available data from patients randomized prior to study","confidence":1,"confidence_rate":1},{"cnt":[[434,1904],[621,1904],[621,1944],[434,1944]],"region":{"top_left_x":433,"top_left_y":1903,"width":188,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ac852f354b745589b7b3ec49a3cf176","type":"text","conversion_output":true,"text":"termination.","text_display":" termination.","confidence":1,"confidence_rate":1},{"cnt":[[434,1998],[1721,1998],[1721,2039],[434,2039]],"region":{"top_left_x":433,"top_left_y":1998,"width":1288,"height":41},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fe11365f9c54e3eabff335f91256e65","type":"text","conversion_output":true,"text":"This Statistical Analysis Plan (SAP) describes the statistical methods to be used for","text_display":"\n\nThis Statistical Analysis Plan (SAP) describes the statistical methods to be used for","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[434,2050],[1618,2050],[1618,2090],[434,2090]],"region":{"top_left_x":433,"top_left_y":2049,"width":1185,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7c3b49dc07142ffa02c58ad1a280fa1","type":"text","conversion_output":true,"text":"the clinical study report of study ML29093. This version of the SAP has been","text_display":" the clinical study report of study ML29093. This version of the SAP has been","confidence":1,"confidence_rate":1},{"cnt":[[434,2103],[1727,2103],[1727,2146],[434,2146]],"region":{"top_left_x":433,"top_left_y":2103,"width":1295,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f779c982204840a385e7d6d3932dffb5","type":"text","conversion_output":true,"text":"developed using version 3 of the study protocol dated 08 Jan 2015. The SAP will be","text_display":" developed using version 3 of the study protocol dated 08 Jan 2015. The SAP will be","confidence":1,"confidence_rate":1},{"cnt":[[434,2157],[612,2157],[612,2198],[434,2198]],"region":{"top_left_x":433,"top_left_y":2157,"width":180,"height":41},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4945de59ca024537a27e6ae352d8dc88","type":"text","conversion_output":true,"text":"finalized by","text_display":" finalized by","confidence":1,"confidence_rate":1},{"cnt":[[614,2151],[1021,2151],[1021,2206],[614,2206]],"region":{"top_left_x":614,"top_left_y":2150,"width":407,"height":57},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc3854f2dfb64bbdbf11a7a5ab1ebdb0","type":"form_field","conversion_output":true,"text":"","text_display":" □","subtype":"box"},{"cnt":[[1027,2157],[1652,2157],[1652,2198],[1027,2198]],"region":{"top_left_x":1026,"top_left_y":2157,"width":627,"height":41},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49f895aa1c92467eb557459cf1ca5ff5","type":"text","conversion_output":true,"text":"and approved by Genentech, Inc. before","text_display":" and approved by Genentech, Inc. before","confidence":1,"confidence_rate":1},{"cnt":[[434,2209],[896,2209],[896,2249],[434,2249]],"region":{"top_left_x":433,"top_left_y":2208,"width":463,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f132932b4ae04836a04145076dfb1de1","type":"text","conversion_output":true,"text":"database lock and unblinding.","text_display":" database lock and unblinding.","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1201,2368],[1201,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c604defdd25b430682d2df372a410d6e","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[587,2402],[587,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2401,"width":154,"height":34},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7258468898ee4ff28b2e327d66a61024","type":"page_info","conversion_output":false,"text":"5/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2406],[1182,2406],[1182,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2406,"width":138,"height":29},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cc0b4e5155614d0f9eb2b4684034b6bd","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"51e82c01ba2149489c81c9ed0d017793","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922086966757888,"confidence_rate":0.9998796716383385},{"cnt":[[372,2608],[692,2608],[692,2643],[372,2643]],"region":{"top_left_x":371,"top_left_y":2608,"width":321,"height":35},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3e530aa569c46848b60a7e2a0401ffd","type":"page_info","conversion_output":false,"text":"766/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-07","page":7,"lines":[{"cnt":[[344,438],[707,438],[707,488],[344,488]],"region":{"top_left_x":343,"top_left_y":438,"width":364,"height":50},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"757264abd6f047b3a4be25eecaf92538","type":"section_header","conversion_output":false,"children_ids":["19ae5862fbbc42ed833e92a553b2cd8e"],"text":"","text_display":""},{"cnt":[[348,443],[703,443],[703,483],[348,483]],"region":{"top_left_x":348,"top_left_y":442,"width":355,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19ae5862fbbc42ed833e92a553b2cd8e","type":"text","conversion_output":true,"parent_id":"757264abd6f047b3a4be25eecaf92538","text":"2. STUDY DESIGN","text_display":"\n\n\\section*{2. STUDY DESIGN}","confidence":1,"confidence_rate":1},{"cnt":[[432,511],[1665,511],[1665,556],[432,556]],"region":{"top_left_x":431,"top_left_y":511,"width":1235,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbb8a4646c5446f8b12647329378ee58","type":"text","conversion_output":true,"text":"This is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the","text_display":"\n\nThis is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the","confidence":1,"confidence_rate":1},{"cnt":[[434,563],[1635,563],[1635,608],[434,608]],"region":{"top_left_x":433,"top_left_y":562,"width":1202,"height":47},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f412de03d10343beb8bea0e9699562d9","type":"text","conversion_output":true,"text":"efficacy and safety of IV alteplase in AIS patients with mild strokes that do not","text_display":" efficacy and safety of IV alteplase in AIS patients with mild strokes that do not","confidence":1,"confidence_rate":1},{"cnt":[[434,614],[1704,614],[1704,660],[434,660]],"region":{"top_left_x":433,"top_left_y":614,"width":1271,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"476503d0bae548cfa3920b7630726a07","type":"text","conversion_output":true,"text":"appear to be clearly disabling. The trial will consist of a screening assessment and","text_display":" appear to be clearly disabling. The trial will consist of a screening assessment and","confidence":1,"confidence_rate":1},{"cnt":[[434,666],[1682,666],[1682,713],[434,713]],"region":{"top_left_x":433,"top_left_y":666,"width":1250,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94d0827ad1ad4cd28f01bdc090e4e4e7","type":"text","conversion_output":true,"text":"randomization, treatment followed by a 30-day phone call and a 90-day follow-up","text_display":" randomization, treatment followed by a 30-day phone call and a 90-day follow-up","confidence":0.9839265189366415,"confidence_rate":0.9998071131217847},{"cnt":[[434,718],[1687,718],[1687,763],[434,763]],"region":{"top_left_x":433,"top_left_y":717,"width":1254,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44fad84c74df434e831e5e4f9d183ef7","type":"text","conversion_output":true,"text":"visit. Treatment with the IV study drug should start within 3 hours from last known","text_display":" visit. Treatment with the IV study drug should start within 3 hours from last known","confidence":1,"confidence_rate":1},{"cnt":[[432,769],[956,769],[956,819],[432,819]],"region":{"top_left_x":431,"top_left_y":769,"width":526,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59ba82d3513a440bbb7897253a47100f","type":"text","conversion_output":true,"text":"well time (stroke symptom onset).","text_display":" well time (stroke symptom onset).","confidence":1,"confidence_rate":1},{"cnt":[[432,864],[1594,864],[1594,909],[432,909]],"region":{"top_left_x":431,"top_left_y":863,"width":1164,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79e49203266647678753db06a33a8e27","type":"text","conversion_output":true,"text":"All subjects randomized before the study was terminated will be followed to","text_display":"\n\nAll subjects randomized before the study was terminated will be followed to","confidence":1,"confidence_rate":1},{"cnt":[[434,915],[1175,915],[1175,960],[434,960]],"region":{"top_left_x":433,"top_left_y":915,"width":743,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c88adda0630a4fb6a6b1fe01ee025eb7","type":"text","conversion_output":true,"text":"complete all assessments as originally planned.","text_display":" complete all assessments as originally planned.","confidence":1,"confidence_rate":1},{"cnt":[[327,997],[625,997],[625,1051],[327,1051]],"region":{"top_left_x":326,"top_left_y":996,"width":300,"height":55},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba1a225798414a68b7d1242b17a1be96","type":"section_header","conversion_output":false,"children_ids":["5eb019ebd0ea433586e61b16f3c129c4"],"text":"","text_display":""},{"cnt":[[331,1005],[621,1005],[621,1044],[331,1044]],"region":{"top_left_x":330,"top_left_y":1005,"width":291,"height":40},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5eb019ebd0ea433586e61b16f3c129c4","type":"text","conversion_output":true,"parent_id":"ba1a225798414a68b7d1242b17a1be96","text":"2.1 SYNOPSIS","text_display":"\n\n\\subsection*{2.1 SYNOPSIS}","confidence":1,"confidence_rate":1},{"cnt":[[434,1072],[1740,1072],[1740,1119],[434,1119]],"region":{"top_left_x":433,"top_left_y":1072,"width":1308,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaa353d98cf84faa9372101694ca3b8b","type":"text","conversion_output":true,"text":"The protocol synopsis is provided in Appendix A and the schedule of assessments is","text_display":"\n\nThe protocol synopsis is provided in Appendix A and the schedule of assessments is","confidence":0.94091796875,"confidence_rate":0.999300252779367},{"cnt":[[434,1121],[1721,1121],[1721,1171],[434,1171]],"region":{"top_left_x":433,"top_left_y":1121,"width":1288,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ac76d1401c4498e84f0f3b4284bb46e","type":"text","conversion_output":true,"text":"provided in Appendix B. The study flow chart is provided in Figure 1 in Appendix B.","text_display":" provided in Appendix B. The study flow chart is provided in Figure 1 in Appendix B.","confidence":1,"confidence_rate":1},{"cnt":[[327,1205],[831,1205],[831,1257],[327,1257]],"region":{"top_left_x":326,"top_left_y":1205,"width":506,"height":52},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77293ab190334d5d85997b3df9be4a57","type":"section_header","conversion_output":false,"children_ids":["5fbd3cd0c75741de8403245adb257af2"],"text":"","text_display":""},{"cnt":[[331,1212],[827,1212],[827,1253],[331,1253]],"region":{"top_left_x":330,"top_left_y":1211,"width":498,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5fbd3cd0c75741de8403245adb257af2","type":"text","conversion_output":true,"parent_id":"77293ab190334d5d85997b3df9be4a57","text":"2.2 OUTCOME MEASURES","text_display":"\n\n\\subsection*{2.2 OUTCOME MEASURES}","confidence":1,"confidence_rate":1},{"cnt":[[296,1268],[1051,1268],[1051,1326],[296,1326]],"region":{"top_left_x":296,"top_left_y":1267,"width":755,"height":59},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95dd067034834ed9831fb4932a7ccdaa","type":"section_header","conversion_output":false,"children_ids":["17b8b1aab8674ba888c450bd4cab5827"],"text":"","text_display":""},{"cnt":[[303,1276],[1044,1276],[1044,1321],[303,1321]],"region":{"top_left_x":302,"top_left_y":1276,"width":743,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17b8b1aab8674ba888c450bd4cab5827","type":"text","conversion_output":true,"parent_id":"95dd067034834ed9831fb4932a7ccdaa","text":"2.2.1 Primary Efficacy Outcome Measures","text_display":"\n\n\\subsection*{2.2.1 Primary Efficacy Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[434,1343],[1291,1343],[1291,1388],[434,1388]],"region":{"top_left_x":433,"top_left_y":1342,"width":859,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1146200180cd4a2499964c75eea22b9b","type":"text","conversion_output":true,"text":"The primary efficacy outcome measure for this study is:","text_display":"\n\nThe primary efficacy outcome measure for this study is:","confidence":1,"confidence_rate":1},{"cnt":[[434,1427],[1712,1427],[1712,1474],[434,1474]],"region":{"top_left_x":433,"top_left_y":1426,"width":1280,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47c673e91a34483395b4f32187d6a30c","type":"text","conversion_output":true,"text":"- A favorable functional outcome, defined by a modified Rankin Scale (mRS) of 0","text_display":"\n- A favorable functional outcome, defined by a modified Rankin Scale (mRS) of 0","confidence":1,"confidence_rate":1},{"cnt":[[486,1474],[1016,1474],[1016,1517],[486,1517]],"region":{"top_left_x":485,"top_left_y":1473,"width":532,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6b91c0a891949b08fb5fd849095a1bd","type":"text","conversion_output":true,"text":"or 1 at Day 90 post randomization","text_display":" or 1 at Day 90 post randomization","confidence":1,"confidence_rate":1},{"cnt":[[432,1564],[1624,1564],[1624,1609],[432,1609]],"region":{"top_left_x":431,"top_left_y":1564,"width":1194,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1d055be318048a6a214370aa3a82d17","type":"text","conversion_output":true,"text":"All mRS assessments will be performed by investigators blinded to treatment","text_display":"\n\nAll mRS assessments will be performed by investigators blinded to treatment","confidence":0.96728515625,"confidence_rate":0.9995843121788723},{"cnt":[[434,1616],[1420,1616],[1420,1661],[434,1661]],"region":{"top_left_x":433,"top_left_y":1615,"width":988,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9ae4c5dbc724b379ccbabfcc6a77174","type":"text","conversion_output":true,"text":"assignment that are trained and certified in mRS administration.","text_display":" assignment that are trained and certified in mRS administration.","confidence":0.90478515625,"confidence_rate":0.9986667860554257},{"cnt":[[296,1697],[1098,1697],[1098,1755],[296,1755]],"region":{"top_left_x":296,"top_left_y":1697,"width":802,"height":59},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef0715fe2f484f49a87bb3ded8c43ad1","type":"section_header","conversion_output":false,"children_ids":["0f4bbec39cdf460684c6dbb6e3656763"],"text":"","text_display":""},{"cnt":[[303,1704],[1094,1704],[1094,1749],[303,1749]],"region":{"top_left_x":302,"top_left_y":1703,"width":792,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f4bbec39cdf460684c6dbb6e3656763","type":"text","conversion_output":true,"parent_id":"ef0715fe2f484f49a87bb3ded8c43ad1","text":"2.2.2 Secondary Efficacy Outcome Measures","text_display":"\n\n\\subsection*{2.2.2 Secondary Efficacy Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[434,1770],[1536,1770],[1536,1815],[434,1815]],"region":{"top_left_x":433,"top_left_y":1770,"width":1104,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd9eefeb7da8401e9d2ebedf3554ed2a","type":"text","conversion_output":true,"text":"The secondary efficacy outcomes are measured at Day 90 and include:","text_display":"\n\nThe secondary efficacy outcomes are measured at Day 90 and include:","confidence":1,"confidence_rate":1},{"cnt":[[434,1856],[694,1856],[694,1897],[434,1897]],"region":{"top_left_x":433,"top_left_y":1856,"width":261,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbbb17685eb345a9b64624c601ab9e96","type":"text","conversion_output":true,"text":"- Ordinal mRS","text_display":"\n- Ordinal mRS","confidence":0.99951171875,"confidence_rate":0.9999728670071003},{"cnt":[[434,1921],[1665,1921],[1665,1966],[434,1966]],"region":{"top_left_x":433,"top_left_y":1920,"width":1233,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7579d1b644c4c48bcaaa4f8b70ddc09","type":"text","conversion_output":true,"text":"- Global favorable recovery (Global Outcome Measure derived from mRS 0-1,","text_display":"\n- Global favorable recovery (Global Outcome Measure derived from mRS 0-1,","confidence":0.9990234375,"confidence_rate":0.9999874739291208},{"cnt":[[486,1964],[1691,1964],[1691,2009],[486,2009]],"region":{"top_left_x":485,"top_left_y":1963,"width":1206,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a05fe2550cbf4be6bcdf87d3d571b059","type":"text","conversion_output":true,"text":"National Institutes of Health Stroke Scale [NIHSS] 0-1, Barthel Index [BI] \\(\\geq\\) 95,","text_display":" National Institutes of Health Stroke Scale [NIHSS] 0-1, Barthel Index [BI] \\(\\geq\\) 95,","confidence":0.8894572120112798,"confidence_rate":0.9986697052134288},{"cnt":[[486,2007],[1091,2007],[1091,2052],[486,2052]],"region":{"top_left_x":485,"top_left_y":2006,"width":607,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5345c7217164dc8b75f4e23ba599448","type":"text","conversion_output":true,"text":"and Glasgow Outcome Scale [GOS] 1)","text_display":" and Glasgow Outcome Scale [GOS] 1)","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7d2e3e3c5464c4abf9810bbd6b4c507","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[587,2368],[587,2402],[434,2402]],"region":{"top_left_x":433,"top_left_y":2367,"width":154,"height":35},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bbbf369f2f084ab396ee292a411aabd7","type":"page_info","conversion_output":false,"text":"6/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5863751bcfaf4bdeb7932790fdc688da","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f2749263142452a9ee5a3c431aa48b8","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931769268624175,"confidence_rate":0.9998946754435268},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17832a4cdac544c8bd55c43b0c413d86","type":"page_info","conversion_output":false,"text":"767/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-08","page":8,"lines":[{"cnt":[[296,436],[1113,436],[1113,494],[296,494]],"region":{"top_left_x":296,"top_left_y":436,"width":817,"height":59},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1754b37fa33463f8a6323110826d1a6","type":"section_header","conversion_output":false,"children_ids":["2901f14063bd4ba5955557a0f6d5301b"],"text":"","text_display":""},{"cnt":[[301,443],[1109,443],[1109,488],[301,488]],"region":{"top_left_x":300,"top_left_y":442,"width":809,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2901f14063bd4ba5955557a0f6d5301b","type":"text","conversion_output":true,"parent_id":"d1754b37fa33463f8a6323110826d1a6","text":"2.2.3 Exploratory Efficacy Outcome Measures","text_display":"\n\n\\subsection*{2.2.3 Exploratory Efficacy Outcome Measures}","confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[432,511],[1717,511],[1717,556],[432,556]],"region":{"top_left_x":431,"top_left_y":511,"width":1286,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3f1db5334c742bb992b7ad4e40977f0","type":"text","conversion_output":true,"text":"The following exploratory outcome measures for this study are measured at day 90","text_display":"\n\nThe following exploratory outcome measures for this study are measured at day 90","confidence":1,"confidence_rate":1},{"cnt":[[434,563],[1231,563],[1231,608],[434,608]],"region":{"top_left_x":433,"top_left_y":562,"width":799,"height":47},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67cac758d0df4e29b6b7638e202d70c1","type":"text","conversion_output":true,"text":"and included in the analyses described in this SAP:","text_display":" and included in the analyses described in this SAP:","confidence":1,"confidence_rate":1},{"cnt":[[434,649],[973,649],[973,694],[434,694]],"region":{"top_left_x":433,"top_left_y":648,"width":541,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5ff39e5e0a74db897c2c651fc97aa94","type":"text","conversion_output":true,"text":"- Total score of NIHSS at day 90","text_display":"\n- Total score of NIHSS at day 90","confidence":1,"confidence_rate":1},{"cnt":[[434,713],[1721,713],[1721,758],[434,758]],"region":{"top_left_x":433,"top_left_y":713,"width":1288,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c85351ebe2c7457990644c3a953fdafc","type":"text","conversion_output":true,"text":"- Instrumental activities of daily living, as measured by the Total score of the BI at","text_display":"\n- Instrumental activities of daily living, as measured by the Total score of the BI at","confidence":1,"confidence_rate":1},{"cnt":[[486,756],[599,756],[599,801],[486,801]],"region":{"top_left_x":485,"top_left_y":756,"width":115,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fb2ad5242bb4ebd930a5d607b112b4f","type":"text","conversion_output":true,"text":"day 90","text_display":" day 90","confidence":1,"confidence_rate":1},{"cnt":[[434,821],[995,821],[995,866],[434,866]],"region":{"top_left_x":433,"top_left_y":820,"width":562,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abbf555bb96246c1926aa33dbf2cb855","type":"text","conversion_output":true,"text":"- Raw score of the GOS at day 90","text_display":"\n- Raw score of the GOS at day 90","confidence":1,"confidence_rate":1},{"cnt":[[434,883],[1304,883],[1304,930],[434,930]],"region":{"top_left_x":433,"top_left_y":883,"width":872,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eecbe66b1b834f0783cb1c5aa8671204","type":"text","conversion_output":true,"text":"- Cognition and behavior (modified 30 -minute battery):","text_display":"\n- Cognition and behavior (modified 30 -minute battery):","confidence":0.7269988059997559,"confidence_rate":0.9949519835810274},{"cnt":[[494,947],[1106,947],[1106,990],[494,990]],"region":{"top_left_x":494,"top_left_y":947,"width":613,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"785a50c0f5314c19a78c7fc71c5683b5","type":"text","conversion_output":true,"text":"- Controlled Oral Word Association test;","text_display":"\n- Controlled Oral Word Association test;","confidence":1,"confidence_rate":1},{"cnt":[[494,1001],[1497,1001],[1497,1046],[494,1046]],"region":{"top_left_x":494,"top_left_y":1001,"width":1004,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5d6910602154c438806b46ae1e2422d","type":"text","conversion_output":true,"text":"- Hopkins Verbal Learning Test-Revised [HVLT-R] trials 1, 2, and 3;","text_display":"\n- Hopkins Verbal Learning Test-Revised [HVLT-R] trials 1, 2, and 3;","confidence":1,"confidence_rate":1},{"cnt":[[494,1057],[1631,1057],[1631,1102],[494,1102]],"region":{"top_left_x":494,"top_left_y":1057,"width":1137,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d347208b3fcc40a589f6ece714521998","type":"text","conversion_output":true,"text":"- digit symbol coding from the Wechsler Adult Intelligence Scale III [WAIS III];","text_display":"\n- digit symbol coding from the Wechsler Adult Intelligence Scale III [WAIS III];","confidence":1,"confidence_rate":1},{"cnt":[[559,1096],[1119,1096],[1119,1141],[559,1141]],"region":{"top_left_x":558,"top_left_y":1095,"width":562,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"513eff47871146638cb63e1abedf03ce","type":"text","conversion_output":true,"text":"Forward and Backward Digit Span test;","text_display":" Forward and Backward Digit Span test;","confidence":1,"confidence_rate":1},{"cnt":[[494,1152],[1265,1152],[1265,1197],[494,1197]],"region":{"top_left_x":494,"top_left_y":1151,"width":772,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08d98fe0ac9a41c88d2b3f5378c07e37","type":"text","conversion_output":true,"text":"- Benton Judgment of Line Orientation test, form V;","text_display":"\n- Benton Judgment of Line Orientation test, form V;","confidence":0.9956088066101074,"confidence_rate":0.9999214162486258},{"cnt":[[494,1207],[1003,1207],[1003,1250],[494,1250]],"region":{"top_left_x":494,"top_left_y":1207,"width":510,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"609a5bf454db45eebebd88f672937927","type":"text","conversion_output":true,"text":"- HVLT-R trial 4 and recognition;","text_display":"\n- HVLT-R trial 4 and recognition;","confidence":1,"confidence_rate":1},{"cnt":[[494,1263],[1115,1263],[1115,1308],[494,1308]],"region":{"top_left_x":494,"top_left_y":1263,"width":622,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd61db5d1e9d48dca26bdb8255cbdd0f","type":"text","conversion_output":true,"text":"- semantic fluency [Animal Naming test];","text_display":"\n- semantic fluency [Animal Naming test];","confidence":1,"confidence_rate":1},{"cnt":[[494,1317],[1222,1317],[1222,1360],[494,1360]],"region":{"top_left_x":494,"top_left_y":1316,"width":729,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c710f0bc1324ed29ef16b6f827d7b54","type":"text","conversion_output":true,"text":"- Boston Naming Test [BNT; 15-item short form]","text_display":"\n- Boston Naming Test [BNT; 15-item short form]","confidence":1,"confidence_rate":1},{"cnt":[[434,1392],[1386,1392],[1386,1439],[434,1439]],"region":{"top_left_x":433,"top_left_y":1392,"width":953,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da1b6d52c4d4421eabe9b6d81bc6fa65","type":"text","conversion_output":true,"text":"- Ambulatory performance (as measured by walking speed)","text_display":"\n- Ambulatory performance (as measured by walking speed)","confidence":1,"confidence_rate":1},{"cnt":[[434,1454],[1635,1454],[1635,1502],[434,1502]],"region":{"top_left_x":433,"top_left_y":1454,"width":1202,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de70c1138d3344e0b83c6bc994c5312c","type":"text","conversion_output":true,"text":"- Depression (CES-D [Center for Epidemiologic Studies, Depression]) score","text_display":"\n- Depression (CES-D [Center for Epidemiologic Studies, Depression]) score","confidence":1,"confidence_rate":1},{"cnt":[[434,1519],[1465,1519],[1465,1566],[434,1566]],"region":{"top_left_x":433,"top_left_y":1518,"width":1033,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68a500d693e04a7ba130c4a12e58bab6","type":"text","conversion_output":true,"text":"- Quality of Life (EQ-5D [European Quality of Life] questionnaire)","text_display":"\n- Quality of Life (EQ-5D [European Quality of Life] questionnaire)","confidence":1,"confidence_rate":1},{"cnt":[[434,1581],[995,1581],[995,1629],[434,1629]],"region":{"top_left_x":433,"top_left_y":1581,"width":562,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d2d70cf501a45c5ac53094f706d8b21","type":"text","conversion_output":true,"text":"- Stroke Impact Scale-16 (SIS-16)","text_display":"\n- Stroke Impact Scale-16 (SIS-16)","confidence":1,"confidence_rate":1},{"cnt":[[296,1663],[881,1663],[881,1721],[296,1721]],"region":{"top_left_x":296,"top_left_y":1662,"width":585,"height":59},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a87871d6414b4801a0c06b3351f5869e","type":"section_header","conversion_output":false,"children_ids":["4c98fb55946d464c8dc76146a1c53f6c"],"text":"","text_display":""},{"cnt":[[303,1669],[874,1669],[874,1717],[303,1717]],"region":{"top_left_x":302,"top_left_y":1669,"width":573,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c98fb55946d464c8dc76146a1c53f6c","type":"text","conversion_output":true,"parent_id":"a87871d6414b4801a0c06b3351f5869e","text":"2.2.4 Safety Outcome Measures","text_display":"\n\n\\subsection*{2.2.4 Safety Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[434,1738],[1345,1738],[1345,1781],[434,1781]],"region":{"top_left_x":433,"top_left_y":1738,"width":912,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0e2198d37154e60b81e2c4f337dad05","type":"text","conversion_output":true,"text":"The safety outcome measures for this study are as follows:","text_display":"\n\nThe safety outcome measures for this study are as follows:","confidence":1,"confidence_rate":1},{"cnt":[[434,1822],[1663,1822],[1663,1869],[434,1869]],"region":{"top_left_x":433,"top_left_y":1821,"width":1230,"height":49},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fee8d2afa2ea43e5a5959bb321497cca","type":"text","conversion_output":true,"text":"- Symptomatic Intracranial Hemorrhage (sICH) within 36 hours of receiving IV","text_display":"\n- Symptomatic Intracranial Hemorrhage (sICH) within 36 hours of receiving IV","confidence":0.9960975646972656,"confidence_rate":0.9999534526348907},{"cnt":[[486,1867],[1102,1867],[1102,1914],[486,1914]],"region":{"top_left_x":485,"top_left_y":1866,"width":618,"height":49},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b47f9a16cb5d42f8befd0cc075864b8f","type":"text","conversion_output":true,"text":"study drug (primary safety assessment)","text_display":" study drug (primary safety assessment)","confidence":1,"confidence_rate":1},{"cnt":[[486,1955],[1626,1955],[1626,1998],[486,1998]],"region":{"top_left_x":485,"top_left_y":1955,"width":1142,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"751035e6d224425e86aff0105f13d5eb","type":"text","conversion_output":true,"text":"sICH is defined as any neurological decline attributed to new ICH seen on","text_display":"\nsICH is defined as any neurological decline attributed to new ICH seen on","confidence":1,"confidence_rate":1},{"cnt":[[486,1998],[1708,1998],[1708,2041],[486,2041]],"region":{"top_left_x":485,"top_left_y":1998,"width":1224,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"287a5643ec35455c9659f913533f6c16","type":"text","conversion_output":true,"text":"imaging by the investigator (based on AE reporting). New ICH seen on imaging","text_display":" imaging by the investigator (based on AE reporting). New ICH seen on imaging","confidence":1,"confidence_rate":1},{"cnt":[[486,2041],[1579,2041],[1579,2086],[486,2086]],"region":{"top_left_x":485,"top_left_y":2041,"width":1095,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83ac0ba69f69411994aa48e9af86f37c","type":"text","conversion_output":true,"text":"will be later confirmed on independent reading by blinded central study","text_display":" will be later confirmed on independent reading by blinded central study","confidence":1,"confidence_rate":1},{"cnt":[[486,2084],[672,2084],[672,2129],[486,2129]],"region":{"top_left_x":485,"top_left_y":2083,"width":188,"height":47},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4aa42bf3b3d74b0db9d44ef685e42314","type":"text","conversion_output":true,"text":"radiologists","text_display":" radiologists","confidence":1,"confidence_rate":1},{"cnt":[[434,2148],[1732,2148],[1732,2194],[434,2194]],"region":{"top_left_x":433,"top_left_y":2148,"width":1299,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee40e70ceebe4b698dcaa36f5fee4a98","type":"text","conversion_output":true,"text":"- Any ICH (based on central neuroimaging reading) within 36 hours of receiving IV","text_display":"\n- Any ICH (based on central neuroimaging reading) within 36 hours of receiving IV","confidence":1,"confidence_rate":1},{"cnt":[[486,2191],[655,2191],[655,2237],[486,2237]],"region":{"top_left_x":485,"top_left_y":2191,"width":171,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6508913ce83404f996d27d37ec661ca","type":"text","conversion_output":true,"text":"study drug","text_display":" study drug","confidence":1,"confidence_rate":1},{"cnt":[[434,2256],[855,2256],[855,2301],[434,2301]],"region":{"top_left_x":433,"top_left_y":2255,"width":423,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57888b3efa864ea69c2b240c949952e2","type":"text","conversion_output":true,"text":"- Mortality within 90 days","text_display":"\n- Mortality within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ee03c23b5ee4f23ac535c4725934183","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[587,2368],[587,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":154,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81d2376b54d444dfa1d88213b20c5181","type":"text","conversion_output":true,"text":"7/ML29093","text_display":"\n7/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2404],[1044,2404]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b00ec159a32c4c6bac46bd2d36442558","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"468f45a8483940649658dda22b9ce55b","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931764525842368,"confidence_rate":0.9998946680975843},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44c5877fd415433da9ce794331aaf351","type":"page_info","conversion_output":false,"text":"768/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-09","page":9,"lines":[{"cnt":[[434,443],[1319,443],[1319,483],[434,483]],"region":{"top_left_x":433,"top_left_y":442,"width":887,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5e8075160444f8fb93bd51d26d51652","type":"text","conversion_output":true,"text":"- Stroke-related and neurological deaths within 90 days","text_display":"\n- Stroke-related and neurological deaths within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[434,505],[1697,505],[1697,548],[434,548]],"region":{"top_left_x":433,"top_left_y":504,"width":1265,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50576d998fc949b793194dd475cd2dee","type":"text","conversion_output":true,"text":"- Incidence, severity, and spectrum of all adverse events (AEs) and serious AEs","text_display":"\n- Incidence, severity, and spectrum of all adverse events (AEs) and serious AEs","confidence":1,"confidence_rate":1},{"cnt":[[486,546],[612,546],[612,591],[486,591]],"region":{"top_left_x":485,"top_left_y":545,"width":128,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd6f61cbbd8f40b19a05a022c6aff612","type":"text","conversion_output":true,"text":"(SAEs).","text_display":" (SAEs).","confidence":1,"confidence_rate":1},{"cnt":[[434,640],[1179,640],[1179,681],[434,681]],"region":{"top_left_x":433,"top_left_y":640,"width":747,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22232d18b2f341b38237a7d9a2fe75cd","type":"text","conversion_output":true,"text":"The exploratory safety measure for this study is:","text_display":"\n\nThe exploratory safety measure for this study is:","confidence":1,"confidence_rate":1},{"cnt":[[434,724],[1403,724],[1403,767],[434,767]],"region":{"top_left_x":433,"top_left_y":724,"width":970,"height":43},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0e89d4897804ae0a6c805d19f2f4cf5","type":"text","conversion_output":true,"text":"- Stroke recurrence (based on AE monitoring) within 90 days","text_display":"\n- Stroke recurrence (based on AE monitoring) within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[327,804],[1033,804],[1033,853],[327,853]],"region":{"top_left_x":326,"top_left_y":803,"width":708,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6f7ef39434a487cb057d01cb375802d","type":"section_header","conversion_output":false,"children_ids":["7738327ae801411a9b3bd4487b62c286"],"text":"","text_display":""},{"cnt":[[331,812],[1029,812],[1029,849],[331,849]],"region":{"top_left_x":330,"top_left_y":812,"width":700,"height":37},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7738327ae801411a9b3bd4487b62c286","type":"text","conversion_output":true,"parent_id":"b6f7ef39434a487cb057d01cb375802d","text":"2.3 DETERMINATION OF SAMPLE SIZE","text_display":"\n\n\\subsection*{2.3 DETERMINATION OF SAMPLE SIZE}","confidence":1,"confidence_rate":1},{"cnt":[[434,879],[1265,879],[1265,922],[434,922]],"region":{"top_left_x":433,"top_left_y":878,"width":833,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1584f0122d041b3a856f3900a55c964","type":"text","conversion_output":true,"text":"The sample size was originally determined as follows.","text_display":"\n\nThe sample size was originally determined as follows.","confidence":1,"confidence_rate":1},{"cnt":[[432,971],[1635,971],[1635,1016],[432,1016]],"region":{"top_left_x":431,"top_left_y":971,"width":1204,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48349505aacb4176be9a97f41d0c082c","type":"text","conversion_output":true,"text":"A sample size of 856 is required in order to achieve \\(80 \\%\\) power in the primary","text_display":"\n\nA sample size of 856 is required in order to achieve \\(80 \\%\\) power in the primary","confidence":1,"confidence_rate":1},{"cnt":[[434,1023],[1708,1023],[1708,1068],[434,1068]],"region":{"top_left_x":433,"top_left_y":1022,"width":1276,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7464de2f4804417eb500111dc4dd7cd7","type":"text","conversion_output":true,"text":"analysis to detect effect size of \\(9 \\%\\) absolute difference in the proportion of patients","text_display":" analysis to detect effect size of \\(9 \\%\\) absolute difference in the proportion of patients","confidence":0.9658203125,"confidence_rate":0.9996300953042058},{"cnt":[[434,1074],[1635,1074],[1635,1119],[434,1119]],"region":{"top_left_x":433,"top_left_y":1074,"width":1202,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2615d3143c914dd192e493b8dcbe2980","type":"text","conversion_output":true,"text":"with favorable outcomes [mRS of 0 or 1 at Day 90] between the alteplase and","text_display":" with favorable outcomes [mRS of 0 or 1 at Day 90] between the alteplase and","confidence":0.979615671011743,"confidence_rate":0.9997605524317479},{"cnt":[[434,1128],[1712,1128],[1712,1171],[434,1171]],"region":{"top_left_x":433,"top_left_y":1127,"width":1280,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da7307c60b57485493193553c3a57a3c","type":"text","conversion_output":true,"text":"control arms. The above power consideration assumes a control proportion of 65\\%","text_display":" control arms. The above power consideration assumes a control proportion of 65\\%","confidence":0.99267578125,"confidence_rate":0.9999124898705317},{"cnt":[[434,1179],[1717,1179],[1717,1222],[434,1222]],"region":{"top_left_x":433,"top_left_y":1179,"width":1284,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f23f1a5bb8324d87ad5c9de5cf325d98","type":"text","conversion_output":true,"text":"and Type I error of 0.025 (one-sided), and uses a group sequential design with one","text_display":" and Type I error of 0.025 (one-sided), and uses a group sequential design with one","confidence":1,"confidence_rate":1},{"cnt":[[434,1231],[1695,1231],[1695,1274],[434,1274]],"region":{"top_left_x":433,"top_left_y":1231,"width":1263,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b44b49da411c46dfb5605be141f47bd0","type":"text","conversion_output":true,"text":"interim analysis for futility (non-binding), based on O'Brien and Fleming boundary,","text_display":" interim analysis for futility (non-binding), based on O'Brien and Fleming boundary,","confidence":0.9931640625,"confidence_rate":0.999922055202048},{"cnt":[[434,1285],[1708,1285],[1708,1326],[434,1326]],"region":{"top_left_x":433,"top_left_y":1284,"width":1276,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68b5f18c203b4fe0b494a365352c2cb8","type":"text","conversion_output":true,"text":"conducted after 50\\% of the anticipated sample size have completed 90-day follow-","text_display":" conducted after 50\\% of the anticipated sample size have completed 90-day follow","confidence":0.9907341003417969,"confidence_rate":0.9998904872305667},{"cnt":[[434,1336],[698,1336],[698,1379],[434,1379]],"region":{"top_left_x":433,"top_left_y":1336,"width":266,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2987bdf162a4cdf9809cf07f6dd82ad","type":"text","conversion_output":true,"text":"up assessments.","text_display":"up assessments.","confidence":1,"confidence_rate":1},{"cnt":[[829,1341],[1394,1341],[1394,1377],[829,1377]],"region":{"top_left_x":829,"top_left_y":1340,"width":566,"height":38},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e57812cc8cc4717b2e538ab9816de5a","type":"text","conversion_output":true,"text":"was used in sample size calculation.","text_display":" was used in sample size calculation.","confidence":1,"confidence_rate":1},{"cnt":[[434,1431],[1721,1431],[1721,1472],[434,1472]],"region":{"top_left_x":433,"top_left_y":1430,"width":1288,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9321ad51c484123ac2fe0a02e63053f","type":"text","conversion_output":true,"text":"The intention-to-treat principle will be applied to the primary analysis and, therefore,","text_display":"\n\nThe intention-to-treat principle will be applied to the primary analysis and, therefore,","confidence":1,"confidence_rate":1},{"cnt":[[434,1482],[1721,1482],[1721,1523],[434,1523]],"region":{"top_left_x":433,"top_left_y":1482,"width":1288,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"991d0745ec8b4a3a8d821b9e3f46825b","type":"text","conversion_output":true,"text":"to safeguard against dilution of the treatment effect associated with an approximate","text_display":" to safeguard against dilution of the treatment effect associated with an approximate","confidence":1,"confidence_rate":1},{"cnt":[[434,1534],[1663,1534],[1663,1575],[434,1575]],"region":{"top_left_x":433,"top_left_y":1533,"width":1230,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e92eda3d424a46ffbc6643fd3c219f0d","type":"text","conversion_output":true,"text":"\\(5 \\%\\) non adherence rate (due to loss to follow-up, consent withdrawal, treatment","text_display":" \\(5 \\%\\) non adherence rate (due to loss to follow-up, consent withdrawal, treatment","confidence":0.81494140625,"confidence_rate":0.9975075130935339},{"cnt":[[434,1586],[1682,1586],[1682,1629],[434,1629]],"region":{"top_left_x":433,"top_left_y":1585,"width":1250,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d61ca5148994459bc1ac507d65b2f2f","type":"text","conversion_output":true,"text":"crossovers and stroke mimics), the above sample size was inflated by a factor of","text_display":" crossovers and stroke mimics), the above sample size was inflated by a factor of","confidence":1,"confidence_rate":1},{"cnt":[[434,1637],[1583,1637],[1583,1678],[434,1678]],"region":{"top_left_x":433,"top_left_y":1637,"width":1151,"height":41},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e58a1d36cc4f4418bda88e67e83d08db","type":"text","conversion_output":true,"text":"1.108 (5). Therefore, a total sample size of 948 was planned for this study.","text_display":" 1.108 (5). Therefore, a total sample size of 948 was planned for this study.","confidence":0.9990234375,"confidence_rate":0.9999882285072625},{"cnt":[[434,1729],[1678,1729],[1678,1772],[434,1772]],"region":{"top_left_x":433,"top_left_y":1729,"width":1245,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1d74eafe28b4d408d6bf6af33765073","type":"text","conversion_output":true,"text":"The study enrollment was terminated early in December 2016, after 313 patients","text_display":"\n\nThe study enrollment was terminated early in December 2016, after 313 patients","confidence":1,"confidence_rate":1},{"cnt":[[434,1783],[1704,1783],[1704,1824],[434,1824]],"region":{"top_left_x":433,"top_left_y":1783,"width":1271,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52980d89c2be4bbda4ec745a755c5cfb","type":"text","conversion_output":true,"text":"were randomized. The analysis will be carried out based on all available data from","text_display":" were randomized. The analysis will be carried out based on all available data from","confidence":1,"confidence_rate":1},{"cnt":[[434,1835],[1704,1835],[1704,1876],[434,1876]],"region":{"top_left_x":433,"top_left_y":1834,"width":1271,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"833d7c78874542d6aa32cf19b3eea684","type":"text","conversion_output":true,"text":"patients randomized prior to termination. With this sample size, power calculations","text_display":" patients randomized prior to termination. With this sample size, power calculations","confidence":1,"confidence_rate":1},{"cnt":[[434,1886],[1704,1886],[1704,1929],[434,1929]],"region":{"top_left_x":433,"top_left_y":1886,"width":1271,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"827b7138d6504b5192a4655ea6ae79ab","type":"text","conversion_output":true,"text":"show that the study will be substantially underpowered to conduct superiority tests","text_display":" show that the study will be substantially underpowered to conduct superiority tests","confidence":1,"confidence_rate":1},{"cnt":[[434,1938],[1738,1938],[1738,1983],[434,1983]],"region":{"top_left_x":433,"top_left_y":1937,"width":1306,"height":47},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93eed4b27b444bce84a7c5ad89ddaefb","type":"text","conversion_output":true,"text":"(Table 1). Therefore, all efficacy analyses will include estimation of treatment effects","text_display":" (Table 1). Therefore, all efficacy analyses will include estimation of treatment effects","confidence":1,"confidence_rate":1},{"cnt":[[434,1989],[1300,1989],[1300,2030],[434,2030]],"region":{"top_left_x":433,"top_left_y":1989,"width":867,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40277c50acad4ceea5c735385311d3ca","type":"text","conversion_output":true,"text":"with the associated two-sided \\(95 \\%\\) confidence intervals.","text_display":" with the associated two-sided \\(95 \\%\\) confidence intervals.","confidence":0.5771484375,"confidence_rate":0.9913132546544445},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5451edf2b60e44cfb3f404ae71b036a3","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[587,2368],[587,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":154,"height":33},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89c1c0374302450492317558defd5a37","type":"page_info","conversion_output":false,"text":"8/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b5171a5816e4d798d0253f7c649aeb7","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41abbf54f0c44db48c89a28f31580918","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9946386743121138,"confidence_rate":0.9999172995864799},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c9ea0d764cc472ba19c6e407fd52c5a","type":"page_info","conversion_output":false,"text":"769/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-10","page":10,"lines":[{"cnt":[[432,432],[1745,432],[1745,947],[432,947]],"region":{"top_left_x":431,"top_left_y":431,"width":1314,"height":517},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d8653d350dc8442db7616f3135e00ecc","type":"table","conversion_output":true,"children_ids":["066eb59507274f74bad1b8a7e2a15df9","0e4579df3094446d94f5d300813e6ccd","1807a79f51f3433d8c1c985087f8fa95","e1da39e8a2d14763965f68031e22f80f","c117e11ef9134990971e847f1196e5d9","0830b3b77b154946b233d66256afcf04","d171ab7b99de4a74bc4d30b0cb478b18","451a43e5dc1942d2863d1bda54efb86c","3a46e20d2d48454da003d376c6fcc8d7","fb8ed7879e2c4f7ba783dab0fac82269","e4480a5a825041a5b31b2b01ce284f6a","7e189681343842b2a2ef9642cdbed74f","516d90c9a4cd4d95a7a5aeea9baf9776","9138f5fb7bd34d9da6f8302773910d44","3e5341628cd84bb6ba3288de647a36b1","e0c82e0d3fe34b48893269d2ba13f756","188ab8ac0e9447fa8518c8d2049ac681","470acaecfb16448a8feafd6ad9662b22"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline \\multicolumn{4}{|c|}{Table 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )} \\\\\n\\hline Assumed Effect Size & 7\\% & 8\\% & 9\\% \\\\\n\\hline Statistical Power \\({ }^{\\text {a }}\\) & 25\\% & 31\\% & 38\\% \\\\\n\\hline \\multicolumn{4}{|l|}{\\begin{tabular}{l}\n\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided. \\\\\nAssumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report (DSUR) datacut: \\\\\n- Control response rate among confirmed strokes is 74\\%. \\\\\n- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome. \\\\\n- 1\\% of subjects received concomitant tPA \\\\\n- 7.4\\% subjects without Day 90 outcome (290 effective sample size)\n\\end{tabular}} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline \\multicolumn{4}{|c|}{Table 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )} \\\\\n\\hline Assumed Effect Size & 7\\% & 8\\% & 9\\% \\\\\n\\hline Statistical Power \\({ }^{\\text {a }}\\) & 25\\% & 31\\% & 38\\% \\\\\n\\hline \\multicolumn{4}{|l|}{\\begin{tabular}{l}\n\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided. \\\\\nAssumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report (DSUR) datacut: \\\\\n- Control response rate among confirmed strokes is 74\\%. \\\\\n- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome. \\\\\n- 1\\% of subjects received concomitant tPA \\\\\n- 7.4\\% subjects without Day 90 outcome (290 effective sample size)\n\\end{tabular}} \\\\\n\\hline\n\\end{tabular}","confidence":0.99658203125,"confidence_rate":0.9999877721342268},{"cnt":[[438,431],[718,431],[718,947],[438,947]],"region":{"top_left_x":437,"top_left_y":431,"width":282,"height":516},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"066eb59507274f74bad1b8a7e2a15df9","type":"table_column","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[1058,431],[1129,431],[1129,948],[1058,948]],"region":{"top_left_x":1058,"top_left_y":431,"width":71,"height":518},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0e4579df3094446d94f5d300813e6ccd","type":"table_column","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[1381,431],[1383,432],[1384,436],[1384,944],[1381,948],[1317,948],[1307,944],[1305,943],[1316,436],[1317,432],[1319,431]],"region":{"top_left_x":1305,"top_left_y":431,"width":79,"height":517},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1807a79f51f3433d8c1c985087f8fa95","type":"table_column","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[1577,431],[1639,431],[1639,948],[1577,948]],"region":{"top_left_x":1577,"top_left_y":431,"width":63,"height":518},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e1da39e8a2d14763965f68031e22f80f","type":"table_column","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[431,448],[1744,448],[1744,544],[431,544]],"region":{"top_left_x":431,"top_left_y":448,"width":1314,"height":97},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c117e11ef9134990971e847f1196e5d9","type":"table_row","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[431,565],[1746,565],[1746,605],[431,605]],"region":{"top_left_x":431,"top_left_y":565,"width":1315,"height":40},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0830b3b77b154946b233d66256afcf04","type":"table_row","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[431,615],[1746,615],[1746,656],[431,656]],"region":{"top_left_x":431,"top_left_y":614,"width":1315,"height":43},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d171ab7b99de4a74bc4d30b0cb478b18","type":"table_row","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[431,945],[431,666],[1746,668],[1746,947]],"region":{"top_left_x":430,"top_left_y":666,"width":1317,"height":281},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"451a43e5dc1942d2863d1bda54efb86c","type":"table_row","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"","text_display":""},{"cnt":[[438,450],[1677,450],[1677,544],[438,544]],"region":{"top_left_x":437,"top_left_y":449,"width":1241,"height":96},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a46e20d2d48454da003d376c6fcc8d7","type":"table_spanning_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","children_ids":["b8abf2be2969437ea654e520939bddb3"],"text":"","text_display":"Table 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":4},{"cnt":[[685,452],[1491,452],[1491,543],[685,543]],"region":{"top_left_x":685,"top_left_y":451,"width":807,"height":92},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8abf2be2969437ea654e520939bddb3","type":"complex_cell","conversion_output":false,"parent_id":"3a46e20d2d48454da003d376c6fcc8d7","children_ids":["6fd528eac6a7459a81d3ca1cb4ed971b","baae871c1b074e94ae2d7c05a7d03663"],"text":"Table 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )","text_display":"Table 1 Estimated Power for the Final Sample Size ( \\(N =313\\) )","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":4,"confidence":0.8857903480529785,"confidence_rate":0.9990224540462873},{"cnt":[[1026,452],[1148,452],[1148,488],[1026,488]],"region":{"top_left_x":1025,"top_left_y":451,"width":123,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fd528eac6a7459a81d3ca1cb4ed971b","type":"text","conversion_output":false,"parent_id":"b8abf2be2969437ea654e520939bddb3","text":"Table 1","text_display":"Table 1","confidence":1,"confidence_rate":1},{"cnt":[[689,496],[1491,496],[1491,539],[689,539]],"region":{"top_left_x":688,"top_left_y":496,"width":804,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"baae871c1b074e94ae2d7c05a7d03663","type":"text","conversion_output":false,"parent_id":"b8abf2be2969437ea654e520939bddb3","text":"Estimated Power for the Final Sample Size ( \\(N =313\\) )","text_display":" Estimated Power for the Final Sample Size ( \\(N =313\\) )","confidence":0.8857903480529785,"confidence_rate":0.9980458636886663},{"cnt":[[441,570],[715,570],[715,601],[441,601]],"region":{"top_left_x":441,"top_left_y":570,"width":274,"height":32},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fb8ed7879e2c4f7ba783dab0fac82269","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"Assumed Effect Size","text_display":"Assumed Effect Size","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1070,570],[1122,570],[1122,605],[1070,605]],"region":{"top_left_x":1070,"top_left_y":570,"width":52,"height":35},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e4480a5a825041a5b31b2b01ce284f6a","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"7\\%","text_display":"7\\%","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1325,570],[1375,570],[1375,603],[1325,603]],"region":{"top_left_x":1324,"top_left_y":570,"width":51,"height":33},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7e189681343842b2a2ef9642cdbed74f","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"8\\%","text_display":"8\\%","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1586,572],[1634,572],[1634,603],[1586,603]],"region":{"top_left_x":1586,"top_left_y":571,"width":49,"height":32},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"516d90c9a4cd4d95a7a5aeea9baf9776","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"9\\%","text_display":"9\\%","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[441,618],[680,618],[680,653],[441,653]],"region":{"top_left_x":441,"top_left_y":618,"width":240,"height":35},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9138f5fb7bd34d9da6f8302773910d44","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"Statistical Power \\({ }^{\\text {a }}\\)","text_display":"Statistical Power \\({ }^{\\text {a }}\\)","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99658203125,"confidence_rate":0.999902181260292},{"cnt":[[1064,620],[1127,620],[1127,653],[1064,653]],"region":{"top_left_x":1063,"top_left_y":620,"width":65,"height":33},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3e5341628cd84bb6ba3288de647a36b1","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"25\\%","text_display":"25\\%","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1318,620],[1381,620],[1381,653],[1318,653]],"region":{"top_left_x":1317,"top_left_y":620,"width":65,"height":33},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e0c82e0d3fe34b48893269d2ba13f756","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"31\\%","text_display":"31\\%","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1579,620],[1643,620],[1643,653],[1579,653]],"region":{"top_left_x":1579,"top_left_y":620,"width":64,"height":33},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"188ab8ac0e9447fa8518c8d2049ac681","type":"simple_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","text":"38\\%","text_display":"38\\%","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[438,668],[1677,668],[1677,945],[438,945]],"region":{"top_left_x":437,"top_left_y":668,"width":1241,"height":277},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"470acaecfb16448a8feafd6ad9662b22","type":"table_spanning_cell","conversion_output":false,"parent_id":"d8653d350dc8442db7616f3135e00ecc","children_ids":["73f50dbdc3fd47fdb3c5d3f4a1c24da5"],"text":"","text_display":"\\begin{tabular}{l}\n\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided. \\\\\nAssumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report (DSUR) datacut: \\\\\n- Control response rate among confirmed strokes is 74\\%. \\\\\n- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome. \\\\\n- 1\\% of subjects received concomitant tPA \\\\\n- 7.4\\% subjects without Day 90 outcome (290 effective sample size)\n\\end{tabular}","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":4},{"cnt":[[438,670],[1675,670],[1675,945],[438,945]],"region":{"top_left_x":437,"top_left_y":669,"width":1239,"height":276},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","type":"complex_cell","conversion_output":false,"parent_id":"470acaecfb16448a8feafd6ad9662b22","children_ids":["335ab50447e94d4b8610b65061ee5de1","39bca365078d494c8a09ba1b91f148e2","6f1b206be58d46509a5ef26d4e6c408e","bf969204d950447f87c402cfbde61686","95f203f6ccdf4f5f8d5b8172374808be","d6634f9166174935b4448b16c19d4f84","53e45eca7a584b25a2d402d491469e97"],"text":"\\begin{tabular}{l}\n\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided. \\\\\nAssumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report (DSUR) datacut: \\\\\n- Control response rate among confirmed strokes is 74\\%. \\\\\n- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome. \\\\\n- 1\\% of subjects received concomitant tPA \\\\\n- 7.4\\% subjects without Day 90 outcome (290 effective sample size)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\n\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided. \\\\\nAssumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report (DSUR) datacut: \\\\\n- Control response rate among confirmed strokes is 74\\%. \\\\\n- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome. \\\\\n- 1\\% of subjects received concomitant tPA \\\\\n- 7.4\\% subjects without Day 90 outcome (290 effective sample size)\n\\end{tabular}","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":4,"confidence":0.7750896188663319,"confidence_rate":0.9995405169653109},{"cnt":[[441,673],[1581,673],[1581,704],[441,704]],"region":{"top_left_x":441,"top_left_y":673,"width":1140,"height":32},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"335ab50447e94d4b8610b65061ee5de1","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided.","text_display":"\\({ }^{\\text {a }}\\) Based on he t-test for the observed proportions of mRS 0-1 at Day 90, using type I error of 0.025, one-sided.","confidence":0.7750896188663319,"confidence_rate":0.9979958957932257},{"cnt":[[441,715],[1674,715],[1674,746],[441,746]],"region":{"top_left_x":441,"top_left_y":714,"width":1233,"height":32},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"39bca365078d494c8a09ba1b91f148e2","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"Assumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report","text_display":"\nAssumptions are based on a blinded evaluation of non-adherences in the Jan 2017 Development Safety Update Report","confidence":0.9985356330871582,"confidence_rate":0.9999877880733501},{"cnt":[[441,751],[618,751],[618,782],[441,782]],"region":{"top_left_x":441,"top_left_y":750,"width":178,"height":32},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6f1b206be58d46509a5ef26d4e6c408e","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"(DSUR) datacut:","text_display":" (DSUR) datacut:","confidence":1,"confidence_rate":1},{"cnt":[[441,792],[1034,792],[1034,821],[441,821]],"region":{"top_left_x":441,"top_left_y":791,"width":594,"height":31},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bf969204d950447f87c402cfbde61686","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"- Control response rate among confirmed strokes is 74\\%.","text_display":"\n- Control response rate among confirmed strokes is 74\\%.","confidence":0.99365234375,"confidence_rate":0.999893874160367},{"cnt":[[441,831],[1574,831],[1574,862],[441,862]],"region":{"top_left_x":441,"top_left_y":831,"width":1133,"height":32},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"95f203f6ccdf4f5f8d5b8172374808be","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome.","text_display":"\n- 10\\% of randomized subjects are stroke mimics and 80\\% of those stroke mimics will have favorable outcome.","confidence":0.99267578125,"confidence_rate":0.9999337754133857},{"cnt":[[441,871],[883,871],[883,904],[441,904]],"region":{"top_left_x":441,"top_left_y":871,"width":443,"height":33},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d6634f9166174935b4448b16c19d4f84","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"- 1\\% of subjects received concomitant tPA","text_display":"\n- 1\\% of subjects received concomitant tPA","confidence":0.998046875,"confidence_rate":0.9999575001458443},{"cnt":[[441,912],[1144,912],[1144,941],[441,941]],"region":{"top_left_x":441,"top_left_y":912,"width":704,"height":30},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"53e45eca7a584b25a2d402d491469e97","type":"text","conversion_output":false,"parent_id":"73f50dbdc3fd47fdb3c5d3f4a1c24da5","text":"- 7.4\\% subjects without Day 90 outcome (290 effective sample size)","text_display":"\n- 7.4\\% subjects without Day 90 outcome (290 effective sample size)","confidence":0.929776413700329,"confidence_rate":0.9990165496192748},{"cnt":[[327,1036],[752,1036],[752,1085],[327,1085]],"region":{"top_left_x":326,"top_left_y":1035,"width":426,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"125d05cfad9846d79edcd0470c618435","type":"section_header","conversion_output":false,"children_ids":["46a5d87290d74b579f779c7882b07435"],"text":"","text_display":""},{"cnt":[[331,1038],[750,1038],[750,1081],[331,1081]],"region":{"top_left_x":330,"top_left_y":1037,"width":420,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46a5d87290d74b579f779c7882b07435","type":"text","conversion_output":true,"parent_id":"125d05cfad9846d79edcd0470c618435","text":"2.4 ANALYSIS TIMING","text_display":"\n\n\\subsection*{2.4 ANALYSIS TIMING}","confidence":1,"confidence_rate":1},{"cnt":[[434,1109],[1687,1109],[1687,1154],[434,1154]],"region":{"top_left_x":433,"top_left_y":1108,"width":1254,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d966cfce17d4af39a7ffaf95398f5cc","type":"text","conversion_output":true,"text":"One interim analysis of the primary efficacy outcome was planned for clear futility","text_display":"\n\nOne interim analysis of the primary efficacy outcome was planned for clear futility","confidence":1,"confidence_rate":1},{"cnt":[[434,1160],[1714,1160],[1714,1205],[434,1205]],"region":{"top_left_x":433,"top_left_y":1160,"width":1282,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"551f884408c148a999a44572f33f8845","type":"text","conversion_output":true,"text":"once \\(50 \\%\\) of the subjects were enrolled. The interim analysis was to be conducted","text_display":" once \\(50 \\%\\) of the subjects were enrolled. The interim analysis was to be conducted","confidence":0.99658203125,"confidence_rate":0.9999610936733531},{"cnt":[[434,1212],[1601,1212],[1601,1257],[434,1257]],"region":{"top_left_x":433,"top_left_y":1211,"width":1168,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"121512408c7d47d386acb9e7785ef0bf","type":"text","conversion_output":true,"text":"according to the beta-spending approach (9) with an O'Brien - Fleming-type","text_display":" according to the beta-spending approach (9) with an O'Brien - Fleming-type","confidence":1,"confidence_rate":1},{"cnt":[[434,1263],[1727,1263],[1727,1308],[434,1308]],"region":{"top_left_x":433,"top_left_y":1263,"width":1295,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfb7dfe12bf14e098c7c1166abd2a905","type":"text","conversion_output":true,"text":"boundary. Because of the early termination of the study, the interim analysis will not","text_display":" boundary. Because of the early termination of the study, the interim analysis will not","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[434,1317],[655,1317],[655,1360],[434,1360]],"region":{"top_left_x":433,"top_left_y":1316,"width":223,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26380fa85c1a4ceb95c318b486bb2c29","type":"text","conversion_output":true,"text":"be performed.","text_display":" be performed.","confidence":0.99853515625,"confidence_rate":0.9999185634448865},{"cnt":[[346,1401],[748,1401],[748,1448],[346,1448]],"region":{"top_left_x":345,"top_left_y":1400,"width":403,"height":49},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c9d0980d9dc4cc7afa834a2da47c3ad","type":"section_header","conversion_output":false,"children_ids":["d1cc66f8ff2e426fb2710c87a8667543"],"text":"","text_display":""},{"cnt":[[352,1405],[741,1405],[741,1442],[352,1442]],"region":{"top_left_x":352,"top_left_y":1405,"width":390,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1cc66f8ff2e426fb2710c87a8667543","type":"text","conversion_output":true,"parent_id":"6c9d0980d9dc4cc7afa834a2da47c3ad","text":"3. STUDY CONDUCT","text_display":"\n\n\\section*{3. STUDY CONDUCT}","confidence":1,"confidence_rate":1},{"cnt":[[327,1463],[879,1463],[879,1515],[327,1515]],"region":{"top_left_x":326,"top_left_y":1463,"width":553,"height":52},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"662b24d503a04fa89121f45525859d95","type":"section_header","conversion_output":false,"children_ids":["7571320dd7b148b59526a81f2a08fd6c"],"text":"","text_display":""},{"cnt":[[331,1470],[874,1470],[874,1508],[331,1508]],"region":{"top_left_x":330,"top_left_y":1469,"width":545,"height":40},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7571320dd7b148b59526a81f2a08fd6c","type":"text","conversion_output":true,"parent_id":"662b24d503a04fa89121f45525859d95","text":"3.1 RANDOMIZATION ISSUES","text_display":"\n\n\\subsection*{3.1 RANDOMIZATION ISSUES}","confidence":1,"confidence_rate":1},{"cnt":[[434,1538],[1596,1538],[1596,1579],[434,1579]],"region":{"top_left_x":433,"top_left_y":1538,"width":1164,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"946d0dcc71364256aaf64962318b2c89","type":"text","conversion_output":true,"text":"Due to the emergency nature of randomization in acute stroke clinical trials,","text_display":"\n\nDue to the emergency nature of randomization in acute stroke clinical trials,","confidence":1,"confidence_rate":1},{"cnt":[[434,1590],[1695,1590],[1695,1631],[434,1631]],"region":{"top_left_x":433,"top_left_y":1589,"width":1263,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e421a6f94145492d9016e3b0cbaa9b06","type":"text","conversion_output":true,"text":"treatment assignments must be made in an expeditious manner that also ensures","text_display":" treatment assignments must be made in an expeditious manner that also ensures","confidence":1,"confidence_rate":1},{"cnt":[[434,1641],[1691,1641],[1691,1684],[434,1684]],"region":{"top_left_x":433,"top_left_y":1641,"width":1258,"height":44},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2659edb48d4c49a98ea151d0a80020e4","type":"text","conversion_output":true,"text":"even distribution in the treatment groups. A \"step forward\" randomization regimen","text_display":" even distribution in the treatment groups. A \"step forward\" randomization regimen","confidence":1,"confidence_rate":1},{"cnt":[[434,1693],[1678,1693],[1678,1738],[434,1738]],"region":{"top_left_x":433,"top_left_y":1692,"width":1245,"height":47},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"712b820fdee341e1807087e7ad8d247c","type":"text","conversion_output":true,"text":"will be used to ensure that a randomized treatment assignment is available upon","text_display":" will be used to ensure that a randomized treatment assignment is available upon","confidence":1,"confidence_rate":1},{"cnt":[[434,1745],[1704,1745],[1704,1790],[434,1790]],"region":{"top_left_x":433,"top_left_y":1744,"width":1271,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7092791c268b45119eb79ccd754eeb42","type":"text","conversion_output":true,"text":"patients' arrival at the hospital and treatment can initiate immediately upon signing","text_display":" patients' arrival at the hospital and treatment can initiate immediately upon signing","confidence":1,"confidence_rate":1},{"cnt":[[434,1796],[1253,1796],[1253,1841],[434,1841]],"region":{"top_left_x":433,"top_left_y":1796,"width":820,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19f3000682164fd293917ab395318b48","type":"text","conversion_output":true,"text":"the informed consent and eligibility confirmation (16).","text_display":" the informed consent and eligibility confirmation (16).","confidence":1,"confidence_rate":1},{"cnt":[[434,1891],[1669,1891],[1669,1936],[434,1936]],"region":{"top_left_x":433,"top_left_y":1890,"width":1237,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99b947695a5742198af8457e676ffdab","type":"text","conversion_output":true,"text":"This procedure will be implemented using an Interactive Web Response System","text_display":"\n\nThis procedure will be implemented using an Interactive Web Response System","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[434,1942],[1699,1942],[1699,1987],[434,1987]],"region":{"top_left_x":433,"top_left_y":1942,"width":1267,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebb0ab4b366d4c5b88f2429ae47609f6","type":"text","conversion_output":true,"text":"(IWRS). Before the first patient is enrolled at a site, the site will register with IWRS","text_display":" (IWRS). Before the first patient is enrolled at a site, the site will register with IWRS","confidence":1,"confidence_rate":1},{"cnt":[[434,1994],[1669,1994],[1669,2039],[434,2039]],"region":{"top_left_x":433,"top_left_y":1993,"width":1237,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f93b38d49bd40b3884805b259a44585","type":"text","conversion_output":true,"text":"as part of site activation and \"Use Next\" drug kit IDs will be allocated for the first","text_display":" as part of site activation and \"Use Next\" drug kit IDs will be allocated for the first","confidence":1,"confidence_rate":1},{"cnt":[[434,2045],[1740,2045],[1740,2090],[434,2090]],"region":{"top_left_x":433,"top_left_y":2045,"width":1308,"height":46},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6eb4f0598f1496f97dccd8d850e55b7","type":"text","conversion_output":true,"text":"potential patient. This assigned kit will be used to treat the first patient enrolled at the","text_display":" potential patient. This assigned kit will be used to treat the first patient enrolled at the","confidence":1,"confidence_rate":1},{"cnt":[[434,2097],[1635,2097],[1635,2142],[434,2142]],"region":{"top_left_x":433,"top_left_y":2096,"width":1202,"height":46},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00d9c284e56e4dd2bcad0a114ba74afe","type":"text","conversion_output":true,"text":"site. Next, the study site enters identification information of the patient AFTER","text_display":" site. Next, the study site enters identification information of the patient AFTER","confidence":1,"confidence_rate":1},{"cnt":[[434,2148],[1714,2148],[1714,2194],[434,2194]],"region":{"top_left_x":433,"top_left_y":2148,"width":1282,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58c60eb156a442df9429f4b79694b802","type":"text","conversion_output":true,"text":"he/she is treated (within 8 hours of initiation of the patient's study treatment). IWRS","text_display":" he/she is treated (within 8 hours of initiation of the patient's study treatment). IWRS","confidence":1,"confidence_rate":1},{"cnt":[[434,2200],[1712,2200],[1712,2245],[434,2245]],"region":{"top_left_x":433,"top_left_y":2200,"width":1280,"height":46},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46b2b2a3b0c74372bc76f31985986115","type":"text","conversion_output":true,"text":"will then assign \"Use Next\" drug kit IDs for the next patient that becomes eligible at","text_display":" will then assign \"Use Next\" drug kit IDs for the next patient that becomes eligible at","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b8f63aaeb58407fa3cd35898ed4b334","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[587,2368],[587,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":154,"height":33},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bafc711bd95840cc9f8ead8e66a74c9d","type":"page_info","conversion_output":false,"text":"9/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d968e1f952154b9185506abdad0d73ec","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5917769b2371431386938a1239ac811b","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9965858445502818,"confidence_rate":0.9999473860460373},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ceee053454f140d2936db7164f7a5420","type":"page_info","conversion_output":false,"text":"770/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-11","page":11,"lines":[{"cnt":[[434,447],[1740,447],[1740,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1308,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"356b81d0da3b4d45a50e9da4919f7154","type":"text","conversion_output":true,"text":"that site. Randomization is triggered as soon as the \"Use Next\" drug kits are used to","text_display":"\nthat site. Randomization is triggered as soon as the \"Use Next\" drug kits are used to","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[799,498],[799,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":367,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2958b8999f3d4cb5a91107f5141f137e","type":"text","conversion_output":true,"text":"treat an eligible patient.","text_display":" treat an eligible patient.","confidence":1,"confidence_rate":1},{"cnt":[[432,593],[1656,593],[1656,638],[432,638]],"region":{"top_left_x":431,"top_left_y":592,"width":1226,"height":47},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c13329d7658c47cca69c59ebb08e1250","type":"text","conversion_output":true,"text":"Allocation of the \"Use Next\" kits will be determined by a dynamic randomization","text_display":"\n\nAllocation of the \"Use Next\" kits will be determined by a dynamic randomization","confidence":1,"confidence_rate":1},{"cnt":[[434,645],[1629,645],[1629,690],[434,690]],"region":{"top_left_x":433,"top_left_y":644,"width":1196,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7adb72a604d641bfb9898ca8e9edca87","type":"text","conversion_output":true,"text":"algorithm. Particularly, allocation will be balanced within the site using the urn","text_display":" algorithm. Particularly, allocation will be balanced within the site using the urn","confidence":1,"confidence_rate":1},{"cnt":[[434,696],[1652,696],[1652,741],[434,741]],"region":{"top_left_x":433,"top_left_y":696,"width":1220,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b5f7866cec645679b76f8ca0e332efd","type":"text","conversion_output":true,"text":"method (17). In case of perfect balance within site, the overall allocation will be","text_display":" method (17). In case of perfect balance within site, the overall allocation will be","confidence":1,"confidence_rate":1},{"cnt":[[434,748],[1626,748],[1626,793],[434,793]],"region":{"top_left_x":433,"top_left_y":747,"width":1194,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2ef5336a16d49cdbb5b4c577c8791c1","type":"text","conversion_output":true,"text":"balanced using the biased coin method (14, 15). More details are available in","text_display":" balanced using the biased coin method (14, 15). More details are available in","confidence":0.5062603169353679,"confidence_rate":0.9917330886847506},{"cnt":[[434,799],[629,799],[629,844],[434,844]],"region":{"top_left_x":433,"top_left_y":799,"width":197,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26236a82689b44a6b83d90fe776573d3","type":"text","conversion_output":true,"text":"Appendix C.","text_display":" Appendix C.","confidence":0.99951171875,"confidence_rate":0.9999694754347522},{"cnt":[[329,885],[778,885],[778,930],[329,930]],"region":{"top_left_x":328,"top_left_y":885,"width":450,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd7a6fc3a8e743fe8a8d5db28a75d61e","type":"section_header","conversion_output":false,"children_ids":["9d9c52f9be9244efb6391b4a29c58dfc"],"text":"","text_display":""},{"cnt":[[333,889],[776,889],[776,926],[333,926]],"region":{"top_left_x":333,"top_left_y":889,"width":443,"height":37},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d9c52f9be9244efb6391b4a29c58dfc","type":"text","conversion_output":true,"parent_id":"bd7a6fc3a8e743fe8a8d5db28a75d61e","text":"3.2 DATA MONITORING","text_display":"\n\n\\subsection*{3.2 DATA MONITORING}","confidence":1,"confidence_rate":1},{"cnt":[[434,958],[1704,958],[1704,999],[434,999]],"region":{"top_left_x":433,"top_left_y":958,"width":1271,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83992b8bcbfb4c97af2ffd32504d9f72","type":"text","conversion_output":true,"text":"An independent Data Monitoring Committee (iDMC) will provide ongoing review of","text_display":"\n\nAn independent Data Monitoring Committee (iDMC) will provide ongoing review of","confidence":0.998046875,"confidence_rate":0.9999764456408323},{"cnt":[[434,1010],[1717,1010],[1717,1053],[434,1053]],"region":{"top_left_x":433,"top_left_y":1009,"width":1284,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd372676daaf4283815ee1292949b367","type":"text","conversion_output":true,"text":"safety outcomes and review efficacy and safety outcomes to inform a futility interim","text_display":" safety outcomes and review efficacy and safety outcomes to inform a futility interim","confidence":1,"confidence_rate":1},{"cnt":[[434,1061],[1594,1061],[1594,1104],[434,1104]],"region":{"top_left_x":433,"top_left_y":1061,"width":1162,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f948ff547b5d43b4b31563ee4f5d06b5","type":"text","conversion_output":true,"text":"analysis after 50\\% of patients have completed or withdrawn from the study.","text_display":" analysis after 50\\% of patients have completed or withdrawn from the study.","confidence":0.9951193332672119,"confidence_rate":0.9999380700685848},{"cnt":[[434,1154],[1695,1154],[1695,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1153,"width":1263,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8b7de2b8bbf42f99775c4400ca07ae8","type":"text","conversion_output":true,"text":"The iDMC will be composed of external advisors. The iDMC will perform functions","text_display":"\n\nThe iDMC will be composed of external advisors. The iDMC will perform functions","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[434,1207],[569,1207],[569,1244],[434,1244]],"region":{"top_left_x":433,"top_left_y":1207,"width":137,"height":37},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6add4b25e548d3b11f84b8b445d2f8","type":"text","conversion_output":true,"text":"such as:","text_display":" such as:","confidence":1,"confidence_rate":1},{"cnt":[[434,1291],[1437,1291],[1437,1334],[434,1334]],"region":{"top_left_x":433,"top_left_y":1291,"width":1005,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18fbdfffd8ac4e47948a8f85866827e7","type":"text","conversion_output":true,"text":"- Review all accumulated safety data at periodic safety reviews","text_display":"\n- Review all accumulated safety data at periodic safety reviews","confidence":1,"confidence_rate":1},{"cnt":[[434,1354],[1588,1354],[1588,1399],[434,1399]],"region":{"top_left_x":433,"top_left_y":1353,"width":1155,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5cfd1d1e23b54da2acfea44cf48b3773","type":"text","conversion_output":true,"text":"- Make recommendation to the Sponsor as to whether it is appropriate to","text_display":"\n- Make recommendation to the Sponsor as to whether it is appropriate to","confidence":1,"confidence_rate":1},{"cnt":[[486,1396],[1646,1396],[1646,1442],[486,1442]],"region":{"top_left_x":485,"top_left_y":1396,"width":1161,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9925a4b521564e7e9f1ea1e0798bc68a","type":"text","conversion_output":true,"text":"discontinue the study after assessing the interim efficacy and safety data in","text_display":" discontinue the study after assessing the interim efficacy and safety data in","confidence":1,"confidence_rate":1},{"cnt":[[486,1444],[651,1444],[651,1485],[486,1485]],"region":{"top_left_x":485,"top_left_y":1443,"width":166,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b2e1d45063643638551ab041f4eea12","type":"text","conversion_output":true,"text":"aggregate","text_display":" aggregate","confidence":1,"confidence_rate":1},{"cnt":[[434,1534],[1605,1534],[1605,1575],[434,1575]],"region":{"top_left_x":433,"top_left_y":1533,"width":1172,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ed17031d6034a03b40e38f0f255e8ca","type":"text","conversion_output":true,"text":"An independent Data Coordinating Center (iDCC) will be responsible for the","text_display":"\n\nAn independent Data Coordinating Center (iDCC) will be responsible for the","confidence":0.9956097602844238,"confidence_rate":0.9999443065494532},{"cnt":[[434,1586],[1089,1586],[1089,1626],[434,1626]],"region":{"top_left_x":433,"top_left_y":1585,"width":657,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7e871a57d5e4f55bb7d6ac2acc96dc7","type":"text","conversion_output":true,"text":"preparation and review of unmasked data.","text_display":" preparation and review of unmasked data.","confidence":1,"confidence_rate":1},{"cnt":[[434,1676],[1695,1676],[1695,1721],[434,1721]],"region":{"top_left_x":433,"top_left_y":1675,"width":1263,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8bc3e8796bc46d99901e9fc26f5767a","type":"text","conversion_output":true,"text":"Details on iDMC membership, activities and timing are available in the Charter for","text_display":"\n\nDetails on iDMC membership, activities and timing are available in the Charter for","confidence":0.99951171875,"confidence_rate":0.9999943862169285},{"cnt":[[434,1727],[1727,1727],[1727,1772],[434,1772]],"region":{"top_left_x":433,"top_left_y":1727,"width":1295,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"045cd8f60cb044099dd26a6e736d363f","type":"text","conversion_output":true,"text":"the iDMC. Elaboration of the analyses that were to be conducted by the iDCC at the","text_display":" the iDMC. Elaboration of the analyses that were to be conducted by the iDCC at the","confidence":1,"confidence_rate":1},{"cnt":[[434,1781],[1712,1781],[1712,1824],[434,1824]],"region":{"top_left_x":433,"top_left_y":1781,"width":1280,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58a7647ab62d4f2087e43e8e7ce37d2f","type":"text","conversion_output":true,"text":"Interim Analysis is contained in the Interim SAP that was developed and signed-off","text_display":" Interim Analysis is contained in the Interim SAP that was developed and signed-off","confidence":1,"confidence_rate":1},{"cnt":[[434,1835],[647,1835],[647,1876],[434,1876]],"region":{"top_left_x":433,"top_left_y":1834,"width":214,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"750d8042d12a447c81018e8998d55eb0","type":"text","conversion_output":true,"text":"for this study.","text_display":" for this study.","confidence":1,"confidence_rate":1},{"cnt":[[301,1916],[801,1916],[801,1970],[301,1970]],"region":{"top_left_x":300,"top_left_y":1916,"width":502,"height":55},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"132754771c3c47788f1bba53812fb203","type":"section_header","conversion_output":false,"children_ids":["a09f3fd1ff0743a4ae83471e5c70985a"],"text":"","text_display":""},{"cnt":[[305,1921],[797,1921],[797,1966],[305,1966]],"region":{"top_left_x":305,"top_left_y":1920,"width":493,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a09f3fd1ff0743a4ae83471e5c70985a","type":"text","conversion_output":true,"parent_id":"132754771c3c47788f1bba53812fb203","text":"3.2.1 Safety Review Timing","text_display":"\n\n\\subsection*{3.2.1 Safety Review Timing}","confidence":1,"confidence_rate":1},{"cnt":[[434,1989],[1669,1989],[1669,2035],[434,2035]],"region":{"top_left_x":433,"top_left_y":1989,"width":1237,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0198d5d707b5418a98c9579d05197755","type":"text","conversion_output":true,"text":"Scheduled iDMC meetings to review safety data were planned to occur after 5\\%","text_display":"\n\nScheduled iDMC meetings to review safety data were planned to occur after 5\\%","confidence":0.90478515625,"confidence_rate":0.9987654816593986},{"cnt":[[434,2041],[1609,2041],[1609,2086],[434,2086]],"region":{"top_left_x":433,"top_left_y":2041,"width":1177,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e4a4719e1124cc3bf05ebfb310c4754","type":"text","conversion_output":true,"text":"(50), 25\\% (237), 50\\% (474), and 75\\% (711) of patients had been enrolled or","text_display":" (50), 25\\% (237), 50\\% (474), and 75\\% (711) of patients had been enrolled or","confidence":0.7562084367615786,"confidence_rate":0.9964690557019277},{"cnt":[[434,2093],[1708,2093],[1708,2138],[434,2138]],"region":{"top_left_x":433,"top_left_y":2092,"width":1276,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b94f914807514685be0cc598f3f0e101","type":"text","conversion_output":true,"text":"approximately annually. The last iDMC meeting prior to study termination was held","text_display":" approximately annually. The last iDMC meeting prior to study termination was held","confidence":1,"confidence_rate":1},{"cnt":[[434,2144],[1661,2144],[1661,2189],[434,2189]],"region":{"top_left_x":433,"top_left_y":2144,"width":1228,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4ffa5c64faa4dcb978e764d49437f84","type":"text","conversion_output":true,"text":"on 03 May 2016, and included 225 enrolled subjects. Safety monitoring reviews","text_display":" on 03 May 2016, and included 225 enrolled subjects. Safety monitoring reviews","confidence":0.97021484375,"confidence_rate":0.99965644830459},{"cnt":[[434,2196],[1635,2196],[1635,2241],[434,2241]],"region":{"top_left_x":433,"top_left_y":2195,"width":1202,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0d30b3c36a748319f95d16e53043ea0","type":"text","conversion_output":true,"text":"included an unblinded evaluation of all adverse events (AEs), serious adverse","text_display":" included an unblinded evaluation of all adverse events (AEs), serious adverse","confidence":1,"confidence_rate":1},{"cnt":[[434,2247],[1689,2247],[1689,2295],[434,2295]],"region":{"top_left_x":433,"top_left_y":2247,"width":1256,"height":48},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c320db121ef49e4ac063fba95b95d03","type":"text","conversion_output":true,"text":"events (SAEs), adverse events of special interest (AESI) including sICH, and any","text_display":" events (SAEs), adverse events of special interest (AESI) including sICH, and any","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93c1e7b9b08544c0a88e93b894cf1704","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1184,2368],[1184,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":751,"height":38},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"094b2211371f430da09825283d72c256","type":"text","conversion_output":true,"text":"10/ML29093 5/17/2017","text_display":"\n10/ML29093 5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4611ef1148bb4403892f4c861d68e127","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9965858445502818,"confidence_rate":0.9999473860460373},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd920103e3d94c5fbbf358cca65f7be7","type":"page_info","conversion_output":false,"text":"771/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-12","page":12,"lines":[{"cnt":[[434,447],[1693,447],[1693,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1260,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e51ed88ec779452da8911b769274f494","type":"text","conversion_output":true,"text":"other protocol-specified tests deemed critical to the safety evaluation of the study.","text_display":"\nother protocol-specified tests deemed critical to the safety evaluation of the study.","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[1613,498],[1613,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1181,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"243d54a53edf47a4abce804182da4cc1","type":"text","conversion_output":true,"text":"However, the sponsor, investigators and other responsible for study conduct","text_display":" However, the sponsor, investigators and other responsible for study conduct","confidence":1,"confidence_rate":1},{"cnt":[[434,550],[715,550],[715,591],[434,591]],"region":{"top_left_x":433,"top_left_y":550,"width":283,"height":41},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a652764f55e54b6a84af531bdc12d5f3","type":"text","conversion_output":true,"text":"remained blinded.","text_display":" remained blinded.","confidence":1,"confidence_rate":1},{"cnt":[[344,632],[853,632],[853,683],[344,683]],"region":{"top_left_x":343,"top_left_y":631,"width":510,"height":53},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a533a9e0c6ee4e5696facff440009295","type":"section_header","conversion_output":false,"children_ids":["15a8fc5be9f54fbca0f9625a162d1311"],"text":"","text_display":""},{"cnt":[[348,638],[849,638],[849,679],[348,679]],"region":{"top_left_x":348,"top_left_y":638,"width":501,"height":41},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15a8fc5be9f54fbca0f9625a162d1311","type":"text","conversion_output":true,"parent_id":"a533a9e0c6ee4e5696facff440009295","text":"4. STATISTICAL METHODS","text_display":"\n\n\\section*{4. STATISTICAL METHODS}","confidence":1,"confidence_rate":1},{"cnt":[[434,707],[1594,707],[1594,752],[434,752]],"region":{"top_left_x":433,"top_left_y":706,"width":1162,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff1ba075326143f1a859cb6fc63c373d","type":"text","conversion_output":true,"text":"Descriptive statistics will be produced for all endpoints. Data listings will be","text_display":"\n\nDescriptive statistics will be produced for all endpoints. Data listings will be","confidence":1,"confidence_rate":1},{"cnt":[[434,761],[1173,761],[1173,806],[434,806]],"region":{"top_left_x":433,"top_left_y":760,"width":741,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"251811e34bc2400381874e1cd23b8fb5","type":"text","conversion_output":true,"text":"generated for specific endpoints as appropriate.","text_display":" generated for specific endpoints as appropriate.","confidence":1,"confidence_rate":1},{"cnt":[[434,851],[1725,851],[1725,896],[434,896]],"region":{"top_left_x":433,"top_left_y":850,"width":1293,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a917116599404ebebbe5c6bb6bbfecc4","type":"text","conversion_output":true,"text":"Categorical variables will be summarized as the number and percentage of patients","text_display":"\n\nCategorical variables will be summarized as the number and percentage of patients","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[434,902],[1738,902],[1738,947],[434,947]],"region":{"top_left_x":433,"top_left_y":902,"width":1306,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9615b6e3b0164f67abfd8a60c2223d1a","type":"text","conversion_output":true,"text":"or occurrences in each response category. Continuous variables will be summarized","text_display":" or occurrences in each response category. Continuous variables will be summarized","confidence":0.9990234375,"confidence_rate":0.9999886391383975},{"cnt":[[434,954],[1644,954],[1644,999],[434,999]],"region":{"top_left_x":433,"top_left_y":953,"width":1211,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffc1467cf9d141f7aaee84a3ede6b141","type":"text","conversion_output":true,"text":"using descriptive statistics (number of observations, mean, standard deviation,","text_display":" using descriptive statistics (number of observations, mean, standard deviation,","confidence":1,"confidence_rate":1},{"cnt":[[434,1005],[1620,1005],[1620,1053],[434,1053]],"region":{"top_left_x":433,"top_left_y":1005,"width":1187,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a0e79c0adba49569f9fc969a8acd9e7","type":"text","conversion_output":true,"text":"median, minimum, maximum). Any required confidence intervals (Cls) will be","text_display":" median, minimum, maximum). Any required confidence intervals (Cls) will be","confidence":0.921875,"confidence_rate":0.998970838311867},{"cnt":[[434,1059],[973,1059],[973,1102],[434,1102]],"region":{"top_left_x":433,"top_left_y":1059,"width":541,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1db0dc94e3a541ba8e9a90b1296999b3","type":"text","conversion_output":true,"text":"constructed as two-sided 95\\% Cls.","text_display":" constructed as two-sided 95\\% Cls.","confidence":0.5568552017211914,"confidence_rate":0.9847114943619895},{"cnt":[[327,1143],[883,1143],[883,1192],[327,1192]],"region":{"top_left_x":326,"top_left_y":1142,"width":558,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b84fd3ecd60a4fd0aa6255d502a65b85","type":"section_header","conversion_output":false,"children_ids":["1b1650518bc24f848c50ce687cebfbf9"],"text":"","text_display":""},{"cnt":[[331,1147],[879,1147],[879,1188],[331,1188]],"region":{"top_left_x":330,"top_left_y":1147,"width":549,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b1650518bc24f848c50ce687cebfbf9","type":"text","conversion_output":true,"parent_id":"b84fd3ecd60a4fd0aa6255d502a65b85","text":"4.1 ANALYSIS POPULATIONS","text_display":"\n\n\\subsection*{4.1 ANALYSIS POPULATIONS}","confidence":1,"confidence_rate":1},{"cnt":[[296,1207],[870,1207],[870,1261],[296,1261]],"region":{"top_left_x":296,"top_left_y":1207,"width":575,"height":55},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a65978429af144ccbcea0c58c862e361","type":"section_header","conversion_output":false,"children_ids":["a2fcbbd772164fedaad7af0c54ed8ba6"],"text":"","text_display":""},{"cnt":[[303,1212],[866,1212],[866,1257],[303,1257]],"region":{"top_left_x":302,"top_left_y":1211,"width":564,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2fcbbd772164fedaad7af0c54ed8ba6","type":"text","conversion_output":true,"parent_id":"a65978429af144ccbcea0c58c862e361","text":"4.1.1 Intent-to-Treat Population","text_display":"\n\n\\subsection*{4.1.1 Intent-to-Treat Population}","confidence":1,"confidence_rate":1},{"cnt":[[432,1280],[1723,1280],[1723,1326],[432,1326]],"region":{"top_left_x":431,"top_left_y":1280,"width":1293,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48ecfac3b1ae4db09242d1ba5a21aa51","type":"text","conversion_output":true,"text":"All randomized patients are included in the intent-to-treat (ITT) population to adhere","text_display":"\n\nAll randomized patients are included in the intent-to-treat (ITT) population to adhere","confidence":1,"confidence_rate":1},{"cnt":[[434,1332],[1656,1332],[1656,1377],[434,1377]],"region":{"top_left_x":433,"top_left_y":1332,"width":1224,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8353e29224084bab9322a9b089b19d12","type":"text","conversion_output":true,"text":"to the ITT principle. For efficacy analyses, treatment groups will be assigned as","text_display":" to the ITT principle. For efficacy analyses, treatment groups will be assigned as","confidence":1,"confidence_rate":1},{"cnt":[[434,1384],[1644,1384],[1644,1429],[434,1429]],"region":{"top_left_x":433,"top_left_y":1383,"width":1211,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73ffcce666a344ddaf203556634e050d","type":"text","conversion_output":true,"text":"randomized (IV Alteplase \\(0.9 mg / kg +\\) Aspirin Placebo, IV Alteplase Placebo +","text_display":" randomized (IV Alteplase \\(0.9 mg / kg +\\) Aspirin Placebo, IV Alteplase Placebo +","confidence":0.9076652821386233,"confidence_rate":0.9988997012236818},{"cnt":[[434,1435],[694,1435],[694,1480],[434,1480]],"region":{"top_left_x":433,"top_left_y":1435,"width":261,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94fc906603e14b8cbd722533e4d40415","type":"text","conversion_output":true,"text":"Aspirin 325 mg ).","text_display":" Aspirin 325 mg ).","confidence":0.9985356330871582,"confidence_rate":0.999945725911931},{"cnt":[[296,1517],[844,1517],[844,1575],[296,1575]],"region":{"top_left_x":296,"top_left_y":1516,"width":549,"height":59},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e13a7b9768b1438f9085cfdc34944de2","type":"section_header","conversion_output":false,"children_ids":["b4aa483ae7cf48c78e1aef3315cda5ed"],"text":"","text_display":""},{"cnt":[[303,1521],[838,1521],[838,1571],[303,1571]],"region":{"top_left_x":302,"top_left_y":1521,"width":536,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4aa483ae7cf48c78e1aef3315cda5ed","type":"text","conversion_output":true,"parent_id":"e13a7b9768b1438f9085cfdc34944de2","text":"4.1.2 Per-Protocol Population","text_display":"\n\n\\subsection*{4.1.2 Per-Protocol Population}","confidence":1,"confidence_rate":1},{"cnt":[[434,1592],[1648,1592],[1648,1635],[434,1635]],"region":{"top_left_x":433,"top_left_y":1591,"width":1215,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32fc7b9ae82f467584203e0fa40e92e9","type":"text","conversion_output":true,"text":"The per-protocol (PP) population is defined as the subset of the ITT population","text_display":"\n\nThe per-protocol (PP) population is defined as the subset of the ITT population","confidence":1,"confidence_rate":1},{"cnt":[[434,1646],[1663,1646],[1663,1689],[434,1689]],"region":{"top_left_x":433,"top_left_y":1645,"width":1230,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d5bb004ca1847e08b4c63cb9103acd5","type":"text","conversion_output":true,"text":"excluding major protocol violators deemed to have the potential to affect patient","text_display":" excluding major protocol violators deemed to have the potential to affect patient","confidence":1,"confidence_rate":1},{"cnt":[[434,1697],[1691,1697],[1691,1742],[434,1742]],"region":{"top_left_x":433,"top_left_y":1697,"width":1258,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a06c7040b39471d98b0c782844a346d","type":"text","conversion_output":true,"text":"outcome in terms of efficacy. No analyses will be performed for the PP population","text_display":" outcome in terms of efficacy. No analyses will be performed for the PP population","confidence":1,"confidence_rate":1},{"cnt":[[434,1749],[1689,1749],[1689,1794],[434,1794]],"region":{"top_left_x":433,"top_left_y":1748,"width":1256,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b302fb2d876b44c7bf1047b8f940a339","type":"text","conversion_output":true,"text":"given the early enrollment termination. However, major protocol deviations will be","text_display":" given the early enrollment termination. However, major protocol deviations will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1800],[1721,1800],[1721,1846],[434,1846]],"region":{"top_left_x":433,"top_left_y":1800,"width":1288,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1a3a614d5f9481da7c32af1a5847d6e","type":"text","conversion_output":true,"text":"identified in a blinded fashion prior to database lock and will be summarized. These","text_display":" identified in a blinded fashion prior to database lock and will be summarized. These","confidence":1,"confidence_rate":1},{"cnt":[[434,1852],[1676,1852],[1676,1897],[434,1897]],"region":{"top_left_x":433,"top_left_y":1851,"width":1243,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0df491278ed542f3b3996560414d875c","type":"text","conversion_output":true,"text":"deviations will be determined based on the medical monitors' records, as well as","text_display":" deviations will be determined based on the medical monitors' records, as well as","confidence":0.9990234375,"confidence_rate":0.9999885054819704},{"cnt":[[434,1904],[1351,1904],[1351,1949],[434,1949]],"region":{"top_left_x":433,"top_left_y":1903,"width":919,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"037990826c584df29d30eec1d6a0a7ab","type":"text","conversion_output":true,"text":"programmatically, using the following criteria at a minimum:","text_display":" programmatically, using the following criteria at a minimum:","confidence":1,"confidence_rate":1},{"cnt":[[434,1989],[1268,1989],[1268,2035],[434,2035]],"region":{"top_left_x":433,"top_left_y":1989,"width":835,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8ed49ad568a4ebcb7d1acfc7ba9f771","type":"text","conversion_output":true,"text":"- Did not receive alteplase treatment as randomized","text_display":"\n- Did not receive alteplase treatment as randomized","confidence":1,"confidence_rate":1},{"cnt":[[434,2054],[1635,2054],[1635,2099],[434,2099]],"region":{"top_left_x":433,"top_left_y":2053,"width":1202,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cab6843b010f4e26b14a26e5d2a5f93a","type":"text","conversion_output":true,"text":"- Received any additional reperfusion therapy (e.g. IV or IA alteplase and/or","text_display":"\n- Received any additional reperfusion therapy (e.g. IV or IA alteplase and/or","confidence":1,"confidence_rate":1},{"cnt":[[486,2097],[836,2097],[836,2142],[486,2142]],"region":{"top_left_x":485,"top_left_y":2096,"width":351,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76d6336a05bb41fa9916b4ce174d145b","type":"text","conversion_output":true,"text":"endovascular therapy)","text_display":" endovascular therapy)","confidence":1,"confidence_rate":1},{"cnt":[[430,2329],[1205,2329],[1205,2374],[430,2374]],"region":{"top_left_x":429,"top_left_y":2328,"width":777,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e6a540c2cff41d18f54f5e9d6fdd976","type":"section_header","conversion_output":false,"children_ids":["63ff7ea072414a5d9b8ccba3d4947f02"],"text":"","text_display":""},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63ff7ea072414a5d9b8ccba3d4947f02","type":"text","conversion_output":true,"parent_id":"4e6a540c2cff41d18f54f5e9d6fdd976","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\n\\section*{Statistical Analysis Plan: Alteplase-Genentech USMA}","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c8ee9cab82143f391f6b3e3d0d20234","type":"text","conversion_output":true,"text":"11/ML29093","text_display":"\n\n11/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c81390bdb68d41c5a8d6a5b404357712","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20770c26c249425f8c17e23a6453ed46","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9917177988746166,"confidence_rate":0.9998720591219105},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49519f23830e4c74a24a6a974fbc042c","type":"page_info","conversion_output":false,"text":"772/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-13","page":13,"lines":[{"cnt":[[301,440],[737,440],[737,492],[301,492]],"region":{"top_left_x":300,"top_left_y":440,"width":437,"height":52},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c495e18256943798a5cb7479ea441dc","type":"section_header","conversion_output":false,"children_ids":["3747e1af613a4154acbe0d5cd05a82ca"],"text":"","text_display":""},{"cnt":[[305,443],[733,443],[733,488],[305,488]],"region":{"top_left_x":305,"top_left_y":442,"width":428,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3747e1af613a4154acbe0d5cd05a82ca","type":"text","conversion_output":true,"parent_id":"4c495e18256943798a5cb7479ea441dc","text":"4.1.3 Safety Population","text_display":"\n\n\\subsection*{4.1.3 Safety Population}","confidence":1,"confidence_rate":1},{"cnt":[[434,511],[1695,511],[1695,556],[434,556]],"region":{"top_left_x":433,"top_left_y":511,"width":1263,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4e519d843b340299cc57badefcf6acb","type":"text","conversion_output":true,"text":"The Safety population is defined as all patients who received any amount of study","text_display":"\n\nThe Safety population is defined as all patients who received any amount of study","confidence":1,"confidence_rate":1},{"cnt":[[434,563],[1669,563],[1669,608],[434,608]],"region":{"top_left_x":433,"top_left_y":562,"width":1237,"height":47},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cdf01f1fc1cd4ab9aa4951102bf76ace","type":"text","conversion_output":true,"text":"drug. For safety analyses, treatment groups will be assigned according to the IV","text_display":" drug. For safety analyses, treatment groups will be assigned according to the IV","confidence":1,"confidence_rate":1},{"cnt":[[434,614],[1704,614],[1704,660],[434,660]],"region":{"top_left_x":433,"top_left_y":614,"width":1271,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd366a3a7da64f71b83a13c6d9a3ec64","type":"text","conversion_output":true,"text":"alteplase/alteplase placebo actually received. Thus, patients who receive active IV","text_display":" alteplase/alteplase placebo actually received. Thus, patients who receive active IV","confidence":1,"confidence_rate":1},{"cnt":[[434,666],[1687,666],[1687,711],[434,711]],"region":{"top_left_x":433,"top_left_y":666,"width":1254,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b26ab373bd794ecfbfe90b06edfa5cec","type":"text","conversion_output":true,"text":"alteplase will be assigned to IV Alteplase \\(0.9 mg / kg +\\) Aspirin Placebo group, and","text_display":" alteplase will be assigned to IV Alteplase \\(0.9 mg / kg +\\) Aspirin Placebo group, and","confidence":0.9419775009155273,"confidence_rate":0.999357476516681},{"cnt":[[434,718],[1714,718],[1714,763],[434,763]],"region":{"top_left_x":433,"top_left_y":717,"width":1282,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81a6926302124427966111d10b1c2b88","type":"text","conversion_output":true,"text":"patients who receive IV alteplase placebo or did not receive the IV study drug (very","text_display":" patients who receive IV alteplase placebo or did not receive the IV study drug (very","confidence":1,"confidence_rate":1},{"cnt":[[434,769],[1622,769],[1622,816],[434,816]],"region":{"top_left_x":433,"top_left_y":769,"width":1190,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"126812292292463a839baa189bd51ec3","type":"text","conversion_output":true,"text":"rare) will be assigned to IV Alteplase Placebo + Aspirin 325 mg group. Group","text_display":" rare) will be assigned to IV Alteplase Placebo + Aspirin 325 mg group. Group","confidence":0.8048772811889648,"confidence_rate":0.9974791656884647},{"cnt":[[434,821],[1622,821],[1622,868],[434,868]],"region":{"top_left_x":433,"top_left_y":820,"width":1190,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c022efe42f884a369f632280e376d33d","type":"text","conversion_output":true,"text":"assignment will not take into account the actual dose of aspirin; however, it is","text_display":" assignment will not take into account the actual dose of aspirin; however, it is","confidence":1,"confidence_rate":1},{"cnt":[[434,872],[1729,872],[1729,922],[434,922]],"region":{"top_left_x":433,"top_left_y":872,"width":1297,"height":50},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4641968ddbd8414197450263c414e919","type":"text","conversion_output":true,"text":"expected that the majority of cases will follow the randomized treatment. Cases who","text_display":" expected that the majority of cases will follow the randomized treatment. Cases who","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[434,924],[1721,924],[1721,969],[434,969]],"region":{"top_left_x":433,"top_left_y":923,"width":1288,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"871a3e910d404fb58a88592e31bf3cf4","type":"text","conversion_output":true,"text":"did not receive treatment as randomized will be listed as described in Section 4.6.1.","text_display":" did not receive treatment as randomized will be listed as described in Section 4.6.1.","confidence":1,"confidence_rate":1},{"cnt":[[329,1010],[988,1010],[988,1059],[329,1059]],"region":{"top_left_x":328,"top_left_y":1009,"width":661,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ba413ae338d4ebbaf773c65f94436b4","type":"section_header","conversion_output":false,"children_ids":["a9964012503a4968ad7d842dc157f450"],"text":"","text_display":""},{"cnt":[[331,1014],[984,1014],[984,1055],[331,1055]],"region":{"top_left_x":330,"top_left_y":1014,"width":654,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9964012503a4968ad7d842dc157f450","type":"text","conversion_output":true,"parent_id":"9ba413ae338d4ebbaf773c65f94436b4","text":"4.2 ANALYSIS OF STUDY CONDUCT","text_display":"\n\n\\subsection*{4.2 ANALYSIS OF STUDY CONDUCT}","confidence":1,"confidence_rate":1},{"cnt":[[434,1083],[1691,1083],[1691,1128],[434,1128]],"region":{"top_left_x":433,"top_left_y":1082,"width":1258,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86b9c62483464140997080f1b59be202","type":"text","conversion_output":true,"text":"The number and percentage of patients who have signed informed consent, been","text_display":"\n\nThe number and percentage of patients who have signed informed consent, been","confidence":1,"confidence_rate":1},{"cnt":[[434,1134],[1699,1134],[1699,1179],[434,1179]],"region":{"top_left_x":433,"top_left_y":1134,"width":1267,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e624eb8245da49a59221ba05a6d3e586","type":"text","conversion_output":true,"text":"randomized in IWRS, received treatment, and completed through Day 30 and Day","text_display":" randomized in IWRS, received treatment, and completed through Day 30 and Day","confidence":1,"confidence_rate":1},{"cnt":[[434,1186],[1704,1186],[1704,1231],[434,1231]],"region":{"top_left_x":433,"top_left_y":1185,"width":1271,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"488e964f0cd14de39161dae705f62250","type":"text","conversion_output":true,"text":"90 (ie, completed the study) will be tabulated overall and for each treatment group.","text_display":" 90 (ie, completed the study) will be tabulated overall and for each treatment group.","confidence":1,"confidence_rate":1},{"cnt":[[434,1240],[1729,1240],[1729,1283],[434,1283]],"region":{"top_left_x":433,"top_left_y":1239,"width":1297,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6c79e35fced46048e15e0f718ca89f9","type":"text","conversion_output":true,"text":"Reasons for not completing the study will also be tabulated overall and by treatment","text_display":" Reasons for not completing the study will also be tabulated overall and by treatment","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[434,1293],[1042,1293],[1042,1334],[434,1334]],"region":{"top_left_x":433,"top_left_y":1293,"width":609,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5619558efd7418cb9531c0b0b50d109","type":"text","conversion_output":true,"text":"group using numbers and percentages.","text_display":" group using numbers and percentages.","confidence":1,"confidence_rate":1},{"cnt":[[434,1384],[1712,1384],[1712,1429],[434,1429]],"region":{"top_left_x":433,"top_left_y":1383,"width":1280,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b6c9cf07547456b8ed77f3edb0d0a6e","type":"text","conversion_output":true,"text":"A summary of the duration of the patient participation in the study will be produced.","text_display":"\n\nA summary of the duration of the patient participation in the study will be produced.","confidence":1,"confidence_rate":1},{"cnt":[[434,1435],[1601,1435],[1601,1480],[434,1480]],"region":{"top_left_x":433,"top_left_y":1435,"width":1168,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66c46f7e825a4644b4e25a973f6fefa8","type":"text","conversion_output":true,"text":"Duration will be calculated as the later date of the last efficacy or last safety","text_display":" Duration will be calculated as the later date of the last efficacy or last safety","confidence":1,"confidence_rate":1},{"cnt":[[434,1487],[1394,1487],[1394,1532],[434,1532]],"region":{"top_left_x":433,"top_left_y":1486,"width":962,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1fcc877e9b3644f493d18e475da5f67b","type":"text","conversion_output":true,"text":"assessment minus the first study drug administration date +1 .","text_display":" assessment minus the first study drug administration date +1 .","confidence":0.99853515625,"confidence_rate":0.999979058538097},{"cnt":[[434,1581],[1676,1581],[1676,1626],[434,1626]],"region":{"top_left_x":433,"top_left_y":1581,"width":1243,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ee98ab73ed54767855d7bdff0fc1dd0","type":"text","conversion_output":true,"text":"The number and percentage of patients included and excluded from the analysis","text_display":"\n\nThe number and percentage of patients included and excluded from the analysis","confidence":1,"confidence_rate":1},{"cnt":[[434,1633],[1708,1633],[1708,1678],[434,1678]],"region":{"top_left_x":433,"top_left_y":1632,"width":1276,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c9e3566a7844df18e65e025a5c26101","type":"text","conversion_output":true,"text":"populations (ITT and safety) will be tabulated overall and for each treatment group.","text_display":" populations (ITT and safety) will be tabulated overall and for each treatment group.","confidence":1,"confidence_rate":1},{"cnt":[[434,1684],[1452,1684],[1452,1729],[434,1729]],"region":{"top_left_x":433,"top_left_y":1684,"width":1020,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f549e1b6198478596c83c1c513e7135","type":"text","conversion_output":true,"text":"Reason(s) for exclusion from each population will be summarized.","text_display":" Reason(s) for exclusion from each population will be summarized.","confidence":1,"confidence_rate":1},{"cnt":[[434,1779],[1601,1779],[1601,1824],[434,1824]],"region":{"top_left_x":433,"top_left_y":1778,"width":1168,"height":47},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86ff64d44e434562b763dea5035e292e","type":"text","conversion_output":true,"text":"Major protocol deviations will be listed and summarized by treatment group.","text_display":"\n\nMajor protocol deviations will be listed and summarized by treatment group.","confidence":0.99951171875,"confidence_rate":0.9999938950124091},{"cnt":[[434,1869],[1687,1869],[1687,1914],[434,1914]],"region":{"top_left_x":433,"top_left_y":1869,"width":1254,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"733af5eb891b4728ab35f28020cd07f2","type":"text","conversion_output":true,"text":"For those patients who are considered to have failed screening, the reason(s) for","text_display":"\n\nFor those patients who are considered to have failed screening, the reason(s) for","confidence":1,"confidence_rate":1},{"cnt":[[434,1921],[956,1921],[956,1966],[434,1966]],"region":{"top_left_x":433,"top_left_y":1920,"width":524,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fede560ba0d04ecc979bd66cbf89951f","type":"text","conversion_output":true,"text":"failure will be provided in a listing.","text_display":" failure will be provided in a listing.","confidence":1,"confidence_rate":1},{"cnt":[[329,2007],[1338,2007],[1338,2052],[329,2052]],"region":{"top_left_x":328,"top_left_y":2006,"width":1011,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ab9d525ff584c528021b721fe508d96","type":"section_header","conversion_output":false,"children_ids":["7245d497512f4c2fbd2706d3a46fb5ef"],"text":"","text_display":""},{"cnt":[[331,2011],[1334,2011],[1334,2047],[331,2047]],"region":{"top_left_x":330,"top_left_y":2010,"width":1005,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7245d497512f4c2fbd2706d3a46fb5ef","type":"text","conversion_output":true,"parent_id":"0ab9d525ff584c528021b721fe508d96","text":"4.3 ANALYSIS OF TREATMENT GROUP COMPARABILITY","text_display":"\n\n\\subsection*{4.3 ANALYSIS OF TREATMENT GROUP COMPARABILITY}","confidence":1,"confidence_rate":1},{"cnt":[[434,2080],[1676,2080],[1676,2123],[434,2123]],"region":{"top_left_x":433,"top_left_y":2079,"width":1243,"height":44},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf388fe7d3c4464ba2cc2617dcf99c77","type":"text","conversion_output":true,"text":"Clinically important demographic and disease characteristics at screening will be","text_display":"\n\nClinically important demographic and disease characteristics at screening will be","confidence":1,"confidence_rate":1},{"cnt":[[434,2131],[1708,2131],[1708,2174],[434,2174]],"region":{"top_left_x":433,"top_left_y":2131,"width":1276,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"999b3a3cfef64c33a305dba022921c3a","type":"text","conversion_output":true,"text":"summarized overall and for each treatment group. Summaries will be produced for","text_display":" summarized overall and for each treatment group. Summaries will be produced for","confidence":1,"confidence_rate":1},{"cnt":[[434,2183],[728,2183],[728,2226],[434,2226]],"region":{"top_left_x":433,"top_left_y":2182,"width":296,"height":44},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ab0a4e89424463fa178cfd5707be7df","type":"text","conversion_output":true,"text":"the ITT population.","text_display":" the ITT population.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5359f451dcbc4d16be59f07dc3c6e5af","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[436,2368],[599,2368],[599,2400],[436,2400]],"region":{"top_left_x":436,"top_left_y":2367,"width":164,"height":33},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9198a73bcdb34f879b0f7e7945269b4d","type":"page_info","conversion_output":false,"text":"12/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c62f3e4033b7435ea158911b602f0176","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8582c43686b241e1ac1852db3eb273b6","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936649702746081,"confidence_rate":0.9999022327614051},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54bfdc325b9e4b5c9473948370654aaf","type":"page_info","conversion_output":false,"text":"773/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-14","page":14,"lines":[{"cnt":[[434,447],[1704,447],[1704,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1271,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77945bdb5b3f4360a40f34a5f2008431","type":"text","conversion_output":true,"text":"Continuous variables will be summarized among patients with non-missing values,","text_display":"\n\nContinuous variables will be summarized among patients with non-missing values,","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[1659,498],[1659,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1226,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8111ad013d84d54819ff9c94f1775bb","type":"text","conversion_output":true,"text":"by the mean, standard deviation, median, first and third quartiles, minimum and","text_display":" by the mean, standard deviation, median, first and third quartiles, minimum and","confidence":1,"confidence_rate":1},{"cnt":[[434,550],[1721,550],[1721,595],[434,595]],"region":{"top_left_x":433,"top_left_y":550,"width":1288,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"090e03e3cd8a4c8890d5d1511f4aaa5d","type":"text","conversion_output":true,"text":"maximum values. The number of patients with non-missing values will be displayed","text_display":" maximum values. The number of patients with non-missing values will be displayed","confidence":1,"confidence_rate":1},{"cnt":[[434,602],[1742,602],[1742,647],[434,647]],"region":{"top_left_x":433,"top_left_y":601,"width":1310,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d813a4b256c24eb7aa10d6ff970e7c53","type":"text","conversion_output":true,"text":"as well. Categorical variables will be summarized using numbers and percentages of","text_display":" as well. Categorical variables will be summarized using numbers and percentages of","confidence":1,"confidence_rate":1},{"cnt":[[434,655],[1618,655],[1618,698],[434,698]],"region":{"top_left_x":433,"top_left_y":655,"width":1185,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db54052b2478492cbee3a31ed79ec341","type":"text","conversion_output":true,"text":"patients in each category; unknown or missing will be included as a separate","text_display":" patients in each category; unknown or missing will be included as a separate","confidence":1,"confidence_rate":1},{"cnt":[[434,709],[582,709],[582,750],[434,750]],"region":{"top_left_x":433,"top_left_y":708,"width":150,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c3128f0005e40d084ac3d5aad1018d9","type":"text","conversion_output":true,"text":"category.","text_display":" category.","confidence":1,"confidence_rate":1},{"cnt":[[434,799],[1635,799],[1635,844],[434,844]],"region":{"top_left_x":433,"top_left_y":799,"width":1202,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"651899573e5749a18f90888563a986cf","type":"text","conversion_output":true,"text":"The variables to be summarized include but are not restricted to the following:","text_display":"\n\nThe variables to be summarized include but are not restricted to the following:","confidence":1,"confidence_rate":1},{"cnt":[[434,885],[1712,885],[1712,930],[434,930]],"region":{"top_left_x":433,"top_left_y":885,"width":1280,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ce95feae40a421e95a2db53ec14b1cf","type":"text","conversion_output":true,"text":"- Demographics: sex, ethnicity, race(s), age (continuous and categorized as < 65","text_display":"\n- Demographics: sex, ethnicity, race(s), age (continuous and categorized as < 65","confidence":0.9834651947021484,"confidence_rate":0.9998015312332555},{"cnt":[[486,928],[617,928],[617,973],[486,973]],"region":{"top_left_x":485,"top_left_y":928,"width":132,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7c6f5c2120d4edabe85aa2c5e5d7168","type":"text","conversion_output":true,"text":"vs. \\(\\geq 65\\) )","text_display":" vs. \\(\\geq 65\\) )","confidence":1,"confidence_rate":1},{"cnt":[[434,993],[1738,993],[1738,1038],[434,1038]],"region":{"top_left_x":433,"top_left_y":992,"width":1306,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bdf2f274036418091405311c86d5eb7","type":"text","conversion_output":true,"text":"- Last known well time to treatment (continuous and categorized as 0-2 hours, > 2-","text_display":"\n- Last known well time to treatment (continuous and categorized as 0-2 hours, > 2","confidence":0.9985356330871582,"confidence_rate":0.9999831560022533},{"cnt":[[486,1036],[836,1036],[836,1081],[486,1081]],"region":{"top_left_x":485,"top_left_y":1035,"width":351,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00dd8f55fe9b4ce581be03f686836bf8","type":"text","conversion_output":true,"text":"3 hours and \\(>3\\) hours)","text_display":"3 hours and \\(>3\\) hours)","confidence":0.60693359375,"confidence_rate":0.982324649646887},{"cnt":[[434,1100],[1723,1100],[1723,1145],[434,1145]],"region":{"top_left_x":433,"top_left_y":1100,"width":1291,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e98ad65e22de4dd0bda9170fa75ed24b","type":"text","conversion_output":true,"text":"- Stroke characteristics: previous stroke (Y/N), RISS or non-RISS, stroke etiology,","text_display":"\n- Stroke characteristics: previous stroke (Y/N), RISS or non-RISS, stroke etiology,","confidence":1,"confidence_rate":1},{"cnt":[[486,1143],[758,1143],[758,1184],[486,1184]],"region":{"top_left_x":485,"top_left_y":1142,"width":274,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38f9dc625a1346bdbd688a1d5e0747b8","type":"text","conversion_output":true,"text":"location of stroke","text_display":" location of stroke","confidence":1,"confidence_rate":1},{"cnt":[[434,1207],[1270,1207],[1270,1250],[434,1250]],"region":{"top_left_x":433,"top_left_y":1207,"width":837,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c91b3eb004504327868b9a4b13ff95da","type":"text","conversion_output":true,"text":"- NIHSS: total score (as continuous and categorical)","text_display":"\n- NIHSS: total score (as continuous and categorical)","confidence":1,"confidence_rate":1},{"cnt":[[434,1272],[1532,1272],[1532,1315],[434,1315]],"region":{"top_left_x":433,"top_left_y":1271,"width":1099,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"338d5083c326401d845089ba3b403f46","type":"text","conversion_output":true,"text":"- Baseline substance use status: smoking and drug/substance abuse","text_display":"\n- Baseline substance use status: smoking and drug/substance abuse","confidence":1,"confidence_rate":1},{"cnt":[[434,1334],[1687,1334],[1687,1377],[434,1377]],"region":{"top_left_x":433,"top_left_y":1334,"width":1254,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fca95dcba0a4ec38cc1085185e1bb08","type":"text","conversion_output":true,"text":"- Medical History (MedDRA), in particular hypertension, diabetes mellitus, atrial","text_display":"\n- Medical History (MedDRA), in particular hypertension, diabetes mellitus, atrial","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[486,1377],[900,1377],[900,1420],[486,1420]],"region":{"top_left_x":485,"top_left_y":1377,"width":416,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22ce7a34309a4ab0afc034500183e42a","type":"text","conversion_output":true,"text":"fibrillation, and prior stroke","text_display":" fibrillation, and prior stroke","confidence":1,"confidence_rate":1},{"cnt":[[434,1439],[1536,1439],[1536,1485],[434,1485]],"region":{"top_left_x":433,"top_left_y":1439,"width":1104,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ba340e5e016417384b0f2eb3c547637","type":"text","conversion_output":true,"text":"- Baseline Vital Signs: systolic and diastolic blood pressure and pulse","text_display":"\n- Baseline Vital Signs: systolic and diastolic blood pressure and pulse","confidence":1,"confidence_rate":1},{"cnt":[[434,1504],[1693,1504],[1693,1549],[434,1549]],"region":{"top_left_x":433,"top_left_y":1503,"width":1260,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a29738785d44cfaa1ea5d6b9c807c61","type":"text","conversion_output":true,"text":"- Use of Aspirin / antiplatelet drugs within 7 days prior to screening/stroke onset","text_display":"\n- Use of Aspirin / antiplatelet drugs within 7 days prior to screening/stroke onset","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[434,1568],[1652,1568],[1652,1613],[434,1613]],"region":{"top_left_x":433,"top_left_y":1568,"width":1220,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60130cc72f8644c988fe7cd182d06e76","type":"text","conversion_output":true,"text":"- Use of Heparin / anticoagulant drugs within 7 days prior to screening/stroke","text_display":"\n- Use of Heparin / anticoagulant drugs within 7 days prior to screening/stroke","confidence":0.99853515625,"confidence_rate":0.999982954590827},{"cnt":[[486,1611],[582,1611],[582,1652],[486,1652]],"region":{"top_left_x":485,"top_left_y":1611,"width":98,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"609b94bf4ab74b4eb8624113cf8c641a","type":"text","conversion_output":true,"text":"onset","text_display":" onset","confidence":1,"confidence_rate":1},{"cnt":[[434,1676],[763,1676],[763,1714],[434,1714]],"region":{"top_left_x":433,"top_left_y":1675,"width":330,"height":40},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53f8fed221e744a29ede9ef9764a976b","type":"text","conversion_output":true,"text":"- Prior medications","text_display":"\n- Prior medications","confidence":1,"confidence_rate":1},{"cnt":[[434,1740],[1111,1740],[1111,1785],[434,1785]],"region":{"top_left_x":433,"top_left_y":1740,"width":678,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89d169ed66824bdf84a1c55da96a8b58","type":"text","conversion_output":true,"text":"- Baseline neuroimaging (central reading)","text_display":"\n- Baseline neuroimaging (central reading)","confidence":1,"confidence_rate":1},{"cnt":[[434,1800],[1555,1800],[1555,1846],[434,1846]],"region":{"top_left_x":433,"top_left_y":1800,"width":1123,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f3de10e01754b36a5916aec99a4ba60","type":"text","conversion_output":true,"text":"- Baseline Lab Parameters: hematology (complete blood count without","text_display":"\n- Baseline Lab Parameters: hematology (complete blood count without","confidence":1,"confidence_rate":1},{"cnt":[[486,1846],[1678,1846],[1678,1893],[486,1893]],"region":{"top_left_x":485,"top_left_y":1845,"width":1193,"height":48},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3f225637fa241cf83f5e2c290d7f43b","type":"text","conversion_output":true,"text":"differential), chemistry (serum glucose), coagulation (international normalized","text_display":" differential), chemistry (serum glucose), coagulation (international normalized","confidence":0.9990234375,"confidence_rate":0.9999883686432659},{"cnt":[[486,1891],[999,1891],[999,1934],[486,1934]],"region":{"top_left_x":485,"top_left_y":1890,"width":515,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78be989a1d3841dc8404f723eb0378cf","type":"text","conversion_output":true,"text":"ratio, partial thromboplastin time)","text_display":" ratio, partial thromboplastin time)","confidence":1,"confidence_rate":1},{"cnt":[[434,1959],[1622,1959],[1622,2004],[434,2004]],"region":{"top_left_x":433,"top_left_y":1959,"width":1190,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ffbd9226fe54c7e8460a78b473b0e80","type":"text","conversion_output":true,"text":"Baseline for NIHSS, vital signs and lab parameters will be defined as the last","text_display":"\n\nBaseline for NIHSS, vital signs and lab parameters will be defined as the last","confidence":1,"confidence_rate":1},{"cnt":[[434,2011],[1412,2011],[1412,2056],[434,2056]],"region":{"top_left_x":433,"top_left_y":2010,"width":979,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24f5402eb55e4830a5aed4deaba98ebd","type":"text","conversion_output":true,"text":"available assessment prior to initiation of any study medication.","text_display":" available assessment prior to initiation of any study medication.","confidence":1,"confidence_rate":1},{"cnt":[[331,2097],[814,2097],[814,2142],[331,2142]],"region":{"top_left_x":330,"top_left_y":2096,"width":485,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae2a33945b584f07bb49f62fb1f4cb78","type":"section_header","conversion_output":false,"children_ids":["52ddbb9342174224923d48a5987727ad"],"text":"","text_display":""},{"cnt":[[335,2101],[812,2101],[812,2138],[335,2138]],"region":{"top_left_x":335,"top_left_y":2101,"width":478,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52ddbb9342174224923d48a5987727ad","type":"text","conversion_output":true,"parent_id":"ae2a33945b584f07bb49f62fb1f4cb78","text":"4.4 EFFICACY ANALYSES","text_display":"\n\n\\subsection*{4.4 EFFICACY ANALYSES}","confidence":0.99609375,"confidence_rate":0.9998494767404883},{"cnt":[[434,2170],[1734,2170],[1734,2211],[434,2211]],"region":{"top_left_x":433,"top_left_y":2169,"width":1301,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a4ccb224dae437c87d14312f9358375","type":"text","conversion_output":true,"text":"All efficacy analyses will be to estimate treatment effects and provide the associated","text_display":"\n\nAll efficacy analyses will be to estimate treatment effects and provide the associated","confidence":1,"confidence_rate":1},{"cnt":[[434,2221],[995,2221],[995,2260],[434,2260]],"region":{"top_left_x":433,"top_left_y":2221,"width":562,"height":40},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d185926f5b5540afbff653e0f206afe2","type":"text","conversion_output":true,"text":"two-sided \\(95 \\%\\) confidence intervals.","text_display":" two-sided \\(95 \\%\\) confidence intervals.","confidence":0.9443628787994385,"confidence_rate":0.9986696117708563},{"cnt":[[434,2331],[1205,2331],[1205,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2331,"width":773,"height":39},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a23898f63f424bfc97dd715bcdab8c5c","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[599,2368],[599,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":167,"height":33},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be09397abe3c4417a91053d251ee0adb","type":"text","conversion_output":true,"text":"13/ML29093","text_display":"\n13/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7a1111948cd49eab2c1ab17771fcbc6","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6d745ae15464011866e64419b153611","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931781182558552,"confidence_rate":0.9998946938966221},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"430d74cf9c9c429fb4f3844efa917f8e","type":"page_info","conversion_output":false,"text":"774/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-15","page":15,"lines":[{"cnt":[[434,447],[1717,447],[1717,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1284,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"434f5fd839cd48d8b71d2e2623ff8a26","type":"text","conversion_output":true,"text":"Endpoints based on mRS will generally use imputation to achieve the complete ITT","text_display":"\n\nEndpoints based on mRS will generally use imputation to achieve the complete ITT","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[434,498],[1721,498],[1721,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1288,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae698e424cdb4e50833b0b617127c3d3","type":"text","conversion_output":true,"text":"set, with the exception of the repeated measures modeling. Other efficacy variables","text_display":" set, with the exception of the repeated measures modeling. Other efficacy variables","confidence":1,"confidence_rate":1},{"cnt":[[434,550],[1158,550],[1158,595],[434,595]],"region":{"top_left_x":433,"top_left_y":550,"width":726,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7a01ae138c04ac7b9a297b5f8abca48","type":"text","conversion_output":true,"text":"will use all available data in the ITT population.","text_display":" will use all available data in the ITT population.","confidence":1,"confidence_rate":1},{"cnt":[[432,645],[1695,645],[1695,690],[432,690]],"region":{"top_left_x":431,"top_left_y":644,"width":1265,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dc44275fc404d1db6a97ce8aa0df669","type":"text","conversion_output":true,"text":"Assessment of efficacy will be conducted based on endpoints collected during the","text_display":"\n\nAssessment of efficacy will be conducted based on endpoints collected during the","confidence":1,"confidence_rate":1},{"cnt":[[434,696],[1652,696],[1652,741],[434,741]],"region":{"top_left_x":433,"top_left_y":696,"width":1220,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f938e634cd25489c8ea4efb399246bdb","type":"text","conversion_output":true,"text":"Day 90 visit. The protocol allows this visit to be scheduled within 14 days of the","text_display":" Day 90 visit. The protocol allows this visit to be scheduled within 14 days of the","confidence":1,"confidence_rate":1},{"cnt":[[434,748],[1712,748],[1712,793],[434,793]],"region":{"top_left_x":433,"top_left_y":747,"width":1280,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29cb9902eb3943e5b62965f5dd12d995","type":"text","conversion_output":true,"text":"target 90 days post-treatment; however, a wider window of 30 days will be adopted","text_display":" target 90 days post-treatment; however, a wider window of 30 days will be adopted","confidence":0.99658203125,"confidence_rate":0.9999627852212962},{"cnt":[[434,799],[982,799],[982,844],[434,844]],"region":{"top_left_x":433,"top_left_y":799,"width":549,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de93e7e8c95b45a7bf10967e373943a2","type":"text","conversion_output":true,"text":"for the purpose of efficacy analysis.","text_display":" for the purpose of efficacy analysis.","confidence":1,"confidence_rate":1},{"cnt":[[434,889],[1620,889],[1620,937],[434,937]],"region":{"top_left_x":433,"top_left_y":889,"width":1187,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38a17ecd3f4044ca8d714162f63873c9","type":"text","conversion_output":true,"text":"More details of imputation approach for mRS are provided in Section 4.7 and","text_display":"\n\nMore details of imputation approach for mRS are provided in Section 4.7 and","confidence":0.9800081164576113,"confidence_rate":0.9997567232682444},{"cnt":[[434,945],[629,945],[629,988],[434,988]],"region":{"top_left_x":433,"top_left_y":945,"width":197,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aad95903a14c43c392b2bafdca54da37","type":"text","conversion_output":true,"text":"Appendix D.","text_display":" Appendix D.","confidence":0.9990234375,"confidence_rate":0.9999389368864386},{"cnt":[[296,1027],[883,1027],[883,1085],[296,1085]],"region":{"top_left_x":296,"top_left_y":1026,"width":588,"height":59},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3578c49e25be4fe2a0cca582665c3a7e","type":"section_header","conversion_output":false,"children_ids":["56109ffb763945cdbe3a815ff33875a8"],"text":"","text_display":""},{"cnt":[[303,1031],[874,1031],[874,1076],[303,1076]],"region":{"top_left_x":302,"top_left_y":1031,"width":573,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56109ffb763945cdbe3a815ff33875a8","type":"text","conversion_output":true,"parent_id":"3578c49e25be4fe2a0cca582665c3a7e","text":"4.4.1 Primary Efficacy Endpoint","text_display":"\n\n\\subsection*{4.4.1 Primary Efficacy Endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[434,1100],[1697,1100],[1697,1145],[434,1145]],"region":{"top_left_x":433,"top_left_y":1100,"width":1265,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c81f5461464d45d19e8e6594e933b398","type":"text","conversion_output":true,"text":"The primary efficacy analysis will estimate the effect of treatment with IV alteplase","text_display":"\n\nThe primary efficacy analysis will estimate the effect of treatment with IV alteplase","confidence":1,"confidence_rate":1},{"cnt":[[434,1154],[1618,1154],[1618,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1153,"width":1185,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b809efb135ee48ccb37862bd00e0455d","type":"text","conversion_output":true,"text":"therapy and with the standard medical care (aspirin) in AIS patients with mild","text_display":" therapy and with the standard medical care (aspirin) in AIS patients with mild","confidence":1,"confidence_rate":1},{"cnt":[[434,1203],[1463,1203],[1463,1248],[434,1248]],"region":{"top_left_x":433,"top_left_y":1203,"width":1031,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8c52e40b81e46b790ea11f5dd408a3d","type":"text","conversion_output":true,"text":"symptoms. The primary efficacy outcome is derived from the mRS .","text_display":" symptoms. The primary efficacy outcome is derived from the mRS .","confidence":1,"confidence_rate":1},{"cnt":[[434,1298],[1725,1298],[1725,1343],[434,1343]],"region":{"top_left_x":433,"top_left_y":1297,"width":1293,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2af13879ab544d0c8359c538f80e40a6","type":"text","conversion_output":true,"text":"The mRS is an assessment of disability with values from 0 (no symptoms at all) to 5","text_display":"\n\nThe mRS is an assessment of disability with values from 0 (no symptoms at all) to 5","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[434,1349],[1704,1349],[1704,1394],[434,1394]],"region":{"top_left_x":433,"top_left_y":1349,"width":1271,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8e19073d1664c30b340b6d55c920119","type":"text","conversion_output":true,"text":"(severe disability); death will be scored as a ' 6 '. The mRS is collected at 30 and 90","text_display":" (severe disability); death will be scored as a ' 6 '. The mRS is collected at 30 and 90","confidence":0.9951212396845222,"confidence_rate":0.9999525185999244},{"cnt":[[434,1401],[1717,1401],[1717,1446],[434,1446]],"region":{"top_left_x":433,"top_left_y":1400,"width":1284,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97cb9e95a63e4c3fa685f578a5f23e3b","type":"text","conversion_output":true,"text":"days after start of study drug administration. If death occurs prior to an assessment","text_display":" days after start of study drug administration. If death occurs prior to an assessment","confidence":1,"confidence_rate":1},{"cnt":[[434,1452],[1691,1452],[1691,1497],[434,1497]],"region":{"top_left_x":433,"top_left_y":1452,"width":1258,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2720331d867c467dade1c610bdda5895","type":"text","conversion_output":true,"text":"day (Day 30 or Day 90 ), the mRS will be considered available and will be set to 6 .","text_display":" day (Day 30 or Day 90 ), the mRS will be considered available and will be set to 6 .","confidence":0.7802665466442704,"confidence_rate":0.9976170774168246},{"cnt":[[434,1547],[1678,1547],[1678,1592],[434,1592]],"region":{"top_left_x":433,"top_left_y":1546,"width":1245,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7944222f52ed4cf6bffca93281fc8088","type":"text","conversion_output":true,"text":"The proportion of patients within each treatment group with a favorable outcome,","text_display":"\n\nThe proportion of patients within each treatment group with a favorable outcome,","confidence":1,"confidence_rate":1},{"cnt":[[434,1598],[1712,1598],[1712,1644],[434,1644]],"region":{"top_left_x":433,"top_left_y":1598,"width":1280,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7faf261dcfc49a88b29f329d9db3077","type":"text","conversion_output":true,"text":"defined by mRS of 0 or 1 at 90 days post-randomization, will be estimated in the IV","text_display":" defined by mRS of 0 or 1 at 90 days post-randomization, will be estimated in the IV","confidence":0.7607421875,"confidence_rate":0.9973485624539038},{"cnt":[[434,1650],[1729,1650],[1729,1695],[434,1695]],"region":{"top_left_x":433,"top_left_y":1650,"width":1297,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6fe7ace02c79411e82bc1f81fd484e44","type":"text","conversion_output":true,"text":"alteplase arm and in the standard medical care arm. Reasons for not performing the","text_display":" alteplase arm and in the standard medical care arm. Reasons for not performing the","confidence":1,"confidence_rate":1},{"cnt":[[434,1702],[1222,1702],[1222,1747],[434,1747]],"region":{"top_left_x":433,"top_left_y":1701,"width":790,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d2a31aa8de04790bd80c5a82039110a","type":"text","conversion_output":true,"text":"assessment of mRS at Day 90 will be summarized.","text_display":" assessment of mRS at Day 90 will be summarized.","confidence":0.9770617485046387,"confidence_rate":0.9996196555168112},{"cnt":[[434,1796],[1742,1796],[1742,1841],[434,1841]],"region":{"top_left_x":433,"top_left_y":1796,"width":1310,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e3f98927b4f4cfeb07285fdd0efdb66","type":"text","conversion_output":true,"text":"The difference in proportions between the two groups will be estimated using the risk","text_display":"\n\nThe difference in proportions between the two groups will be estimated using the risk","confidence":1,"confidence_rate":1},{"cnt":[[434,1848],[1689,1848],[1689,1893],[434,1893]],"region":{"top_left_x":433,"top_left_y":1847,"width":1256,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f803e9a47054285ad3d84814c2d8844","type":"text","conversion_output":true,"text":"difference. The risk difference will be obtained from a linear model with the binary","text_display":" difference. The risk difference will be obtained from a linear model with the binary","confidence":1,"confidence_rate":1},{"cnt":[[434,1899],[1734,1899],[1734,1944],[434,1944]],"region":{"top_left_x":433,"top_left_y":1899,"width":1301,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1ca4d0c5d224b86815a39c0d124f173","type":"text","conversion_output":true,"text":"\\(mRS 0-1\\) outcome as the response, treatment, and age, time from last known well to","text_display":" \\(mRS 0-1\\) outcome as the response, treatment, and age, time from last known well to","confidence":0.9863405227661133,"confidence_rate":0.999841924837416},{"cnt":[[434,1951],[1687,1951],[1687,1996],[434,1996]],"region":{"top_left_x":433,"top_left_y":1950,"width":1254,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"684da44cb5e24e24b795575d274d3ca9","type":"text","conversion_output":true,"text":"treatment, and baseline NIHSS as continuous covariates. Quadratic terms for the","text_display":" treatment, and baseline NIHSS as continuous covariates. Quadratic terms for the","confidence":1,"confidence_rate":1},{"cnt":[[434,2002],[1622,2002],[1622,2047],[434,2047]],"region":{"top_left_x":433,"top_left_y":2002,"width":1190,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea97d4358dfb493cbb04898430a4ecbe","type":"text","conversion_output":true,"text":"continuous covariates may be added to the model, if the Wald p-value for the","text_display":" continuous covariates may be added to the model, if the Wald p-value for the","confidence":0.841796875,"confidence_rate":0.9978761285525971},{"cnt":[[434,2054],[1712,2054],[1712,2099],[434,2099]],"region":{"top_left_x":433,"top_left_y":2053,"width":1280,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f329a02f433b4ac095a71080a3c2d746","type":"text","conversion_output":true,"text":"quadratic term is \\(<0.1\\). No interactions among the covariates will be included in this","text_display":" quadratic term is \\(<0.1\\). No interactions among the covariates will be included in this","confidence":1,"confidence_rate":1},{"cnt":[[434,2110],[544,2110],[544,2146],[434,2146]],"region":{"top_left_x":433,"top_left_y":2109,"width":111,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28be855159cf4465b28550af31875c8c","type":"text","conversion_output":true,"text":"model.","text_display":" model.","confidence":1,"confidence_rate":1},{"cnt":[[432,2200],[1697,2200],[1697,2245],[432,2245]],"region":{"top_left_x":431,"top_left_y":2200,"width":1267,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"17c884a662024abc825756da7801c37b","type":"text","conversion_output":true,"text":"A common approach for implementation of this model is binary regression, a GLM","text_display":"\n\nA common approach for implementation of this model is binary regression, a GLM","confidence":1,"confidence_rate":1},{"cnt":[[434,2252],[1656,2252],[1656,2297],[434,2297]],"region":{"top_left_x":433,"top_left_y":2251,"width":1224,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c800bfb1164a44daaf920e0de77f8fa7","type":"text","conversion_output":true,"text":"with the Bernoulli distribution for the outcome and the identity link function. This","text_display":" with the Bernoulli distribution for the outcome and the identity link function. This","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42fe0ac9276b4d94ae172adc145181e3","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":38},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36afd3a05ccf46c0a95f6c0679f6e0f9","type":"text","conversion_output":true,"text":"14/ML29093","text_display":"\n14/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2402],[1044,2402]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":35},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38e87feeb78b4881a76e8d98f2c35a03","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f3ae8d0e2874a589a27e89d4960657b","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9965846532722935,"confidence_rate":0.9999473676568535},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6a4b8b2750642d2ba6b29b9362c9957","type":"page_info","conversion_output":false,"text":"775/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-16","page":16,"lines":[{"cnt":[[434,447],[1738,447],[1738,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1306,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0893244fcaf4e9d83037b6971ae2e16","type":"text","conversion_output":true,"text":"model has a possibility of non-convergence when the estimated response probability","text_display":"\nmodel has a possibility of non-convergence when the estimated response probability","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[1691,498],[1691,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1258,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"491296357246491ead83f39b8eb49c78","type":"text","conversion_output":true,"text":"falls outside of the \\((0,1)\\) interval. To circumvent the non-convergence problem, an","text_display":" falls outside of the \\((0,1)\\) interval. To circumvent the non-convergence problem, an","confidence":0.9819421768188477,"confidence_rate":0.9997975443253846},{"cnt":[[434,550],[1717,550],[1717,595],[434,595]],"region":{"top_left_x":433,"top_left_y":550,"width":1284,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"652945aff906440fad70532a79184f16","type":"text","conversion_output":true,"text":"approach of using the ordinary least squares with a robust standard error is used in","text_display":" approach of using the ordinary least squares with a robust standard error is used in","confidence":1,"confidence_rate":1},{"cnt":[[434,602],[1734,602],[1734,647],[434,647]],"region":{"top_left_x":433,"top_left_y":601,"width":1301,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ae1368616704ba8bf0b512b51d5f1d8","type":"text","conversion_output":true,"text":"this study. It was shown that if a robust standard error is used with the ordinary least","text_display":" this study. It was shown that if a robust standard error is used with the ordinary least","confidence":1,"confidence_rate":1},{"cnt":[[434,655],[1639,655],[1639,698],[434,698]],"region":{"top_left_x":433,"top_left_y":655,"width":1207,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc2ef024acd4497198b7e799f638a441","type":"text","conversion_output":true,"text":"squares estimation, the estimate of the risk difference is equal or similar to the","text_display":" squares estimation, the estimate of the risk difference is equal or similar to the","confidence":1,"confidence_rate":1},{"cnt":[[434,705],[1725,705],[1725,752],[434,752]],"region":{"top_left_x":433,"top_left_y":704,"width":1293,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9797565c00284a1c9775afd760dd108d","type":"text","conversion_output":true,"text":"estimate from the GLM with an identity link for Bernoulli outcome approach (22, 23).","text_display":" estimate from the GLM with an identity link for Bernoulli outcome approach (22, 23).","confidence":0.7945193648441882,"confidence_rate":0.9974188658622709},{"cnt":[[434,799],[1652,799],[1652,844],[434,844]],"region":{"top_left_x":433,"top_left_y":799,"width":1220,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e365df8c3e34ecea2a3726bcf66b902","type":"text","conversion_output":true,"text":"The primary efficacy analysis will include all ITT patients, with patients grouped","text_display":"\n\nThe primary efficacy analysis will include all ITT patients, with patients grouped","confidence":1,"confidence_rate":1},{"cnt":[[434,851],[1661,851],[1661,896],[434,896]],"region":{"top_left_x":433,"top_left_y":850,"width":1228,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"901f2b76e73b43148b192e1fec396a73","type":"text","conversion_output":true,"text":"according to the treatment assigned at randomization. Missing or out of window","text_display":" according to the treatment assigned at randomization. Missing or out of window","confidence":1,"confidence_rate":1},{"cnt":[[434,902],[1639,902],[1639,947],[434,947]],"region":{"top_left_x":433,"top_left_y":902,"width":1207,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"291073c303944955bbbc584dfdc34e94","type":"text","conversion_output":true,"text":"mRS at Day 90 will be imputed with LOCF or late Day 90 mRS , if available, or","text_display":" mRS at Day 90 will be imputed with LOCF or late Day 90 mRS , if available, or","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,954],[1680,954],[1680,1001],[434,1001]],"region":{"top_left_x":433,"top_left_y":953,"width":1248,"height":49},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"edd12d3e570c4a749b1349604d4891b7","type":"text","conversion_output":true,"text":"simulated with a hot deck method (see Section 4.7 for handling of missing mRS).","text_display":" simulated with a hot deck method (see Section 4.7 for handling of missing mRS).","confidence":0.9345703125,"confidence_rate":0.9992225045425969},{"cnt":[[434,1048],[1699,1048],[1699,1094],[434,1094]],"region":{"top_left_x":433,"top_left_y":1048,"width":1267,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00efd730c0d0490ba62e0263f2b47e39","type":"text","conversion_output":true,"text":"As a supportive analysis of the primary efficacy endpoint, unadjusted or crude risk","text_display":"\n\nAs a supportive analysis of the primary efficacy endpoint, unadjusted or crude risk","confidence":1,"confidence_rate":1},{"cnt":[[434,1100],[1575,1100],[1575,1145],[434,1145]],"region":{"top_left_x":433,"top_left_y":1100,"width":1142,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da890208a1804deb8372fc92c8ecde8c","type":"text","conversion_output":true,"text":"difference will be estimated along with the two-sided \\(95 \\% Cl\\) using normal","text_display":" difference will be estimated along with the two-sided \\(95 \\% Cl\\) using normal","confidence":0.9273161888122559,"confidence_rate":0.9990912483058868},{"cnt":[[434,1154],[1708,1154],[1708,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1153,"width":1276,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"101078bc41084b4180ff371136a292eb","type":"text","conversion_output":true,"text":"approximation. The standard error for the unadjusted risk difference will be derived","text_display":" approximation. The standard error for the unadjusted risk difference will be derived","confidence":0.9970703125,"confidence_rate":0.9999670343924248},{"cnt":[[434,1203],[1317,1203],[1317,1248],[434,1248]],"region":{"top_left_x":433,"top_left_y":1203,"width":884,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11f82e67989543cebdbbb34405ef51ea","type":"text","conversion_output":true,"text":"from the group standard errors, assuming independence:","text_display":" from the group standard errors, assuming independence:","confidence":1,"confidence_rate":1},{"cnt":[[859,1298],[1313,1298],[1313,1429],[859,1429]],"region":{"top_left_x":859,"top_left_y":1297,"width":454,"height":132},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac5f152d63f74864bf86fdfec53bd0a0","type":"math","conversion_output":true,"text":"\\[\nS E(D)=\\sqrt{\\frac{p(1-p)}{N_{1}}+\\frac{q(1-q)}{N_{2}}}\n\\]","text_display":"\n\\[\nS E(D)=\\sqrt{\\frac{p(1-p)}{N_{1}}+\\frac{q(1-q)}{N_{2}}}\n\\]","confidence":1,"confidence_rate":1},{"cnt":[[434,1482],[1661,1482],[1661,1525],[434,1525]],"region":{"top_left_x":433,"top_left_y":1482,"width":1228,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95e22f001c96494aae69046a85a45af9","type":"text","conversion_output":true,"text":"where \\(p\\) and \\(q\\) are the observed group proportions and \\(N_{1}\\) and \\(N_{2}\\) are the group","text_display":"\nwhere \\(p\\) and \\(q\\) are the observed group proportions and \\(N_{1}\\) and \\(N_{2}\\) are the group","confidence":0.99658203125,"confidence_rate":0.9999680021628804},{"cnt":[[434,1534],[651,1534],[651,1577],[434,1577]],"region":{"top_left_x":433,"top_left_y":1533,"width":218,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa149bb395f44428b4fad6e01d25c811","type":"text","conversion_output":true,"text":"sample sizes.","text_display":" sample sizes.","confidence":1,"confidence_rate":1},{"cnt":[[434,1626],[1687,1626],[1687,1669],[434,1669]],"region":{"top_left_x":433,"top_left_y":1626,"width":1254,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7a00862299c4040a507a830250c16e6","type":"text","conversion_output":true,"text":"The treatment effect for the binary mRS outcome will also be evaluated using the","text_display":"\n\nThe treatment effect for the binary mRS outcome will also be evaluated using the","confidence":0.96142578125,"confidence_rate":0.999567808723543},{"cnt":[[434,1680],[1734,1680],[1734,1721],[434,1721]],"region":{"top_left_x":433,"top_left_y":1680,"width":1301,"height":41},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c201a9311c745b589b62acf61b0dd87","type":"text","conversion_output":true,"text":"odds ratio statistic, derived from either a logistic regression, or a repeated measures","text_display":" odds ratio statistic, derived from either a logistic regression, or a repeated measures","confidence":1,"confidence_rate":1},{"cnt":[[434,1727],[1734,1727],[1734,1772],[434,1772]],"region":{"top_left_x":433,"top_left_y":1727,"width":1301,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d62896db6c714f529da3da03c340853c","type":"text","conversion_output":true,"text":"model. These are considered exploratory analyses and described in Section 4.4.3.1.","text_display":" model. These are considered exploratory analyses and described in Section 4.4.3.1.","confidence":1,"confidence_rate":1},{"cnt":[[299,1813],[947,1813],[947,1867],[299,1867]],"region":{"top_left_x":298,"top_left_y":1813,"width":650,"height":54},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7cc60345ae249b381058ea79f97071b","type":"section_header","conversion_output":false,"children_ids":["36e0c8ed76a4484b9f7094c5a21d0973"],"text":"","text_display":""},{"cnt":[[305,1818],[939,1818],[939,1863],[305,1863]],"region":{"top_left_x":305,"top_left_y":1817,"width":634,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36e0c8ed76a4484b9f7094c5a21d0973","type":"text","conversion_output":true,"parent_id":"c7cc60345ae249b381058ea79f97071b","text":"4.4.2 Secondary Efficacy Endpoints","text_display":"\n\n\\subsection*{4.4.2 Secondary Efficacy Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[434,1886],[1738,1886],[1738,1931],[434,1931]],"region":{"top_left_x":433,"top_left_y":1886,"width":1306,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84db8c75e05743879b5ff10b0f22e3fd","type":"text","conversion_output":true,"text":"Secondary efficacy outcomes include mRS (full scale) and global favorable recovery","text_display":"\n\nSecondary efficacy outcomes include mRS (full scale) and global favorable recovery","confidence":1,"confidence_rate":1},{"cnt":[[434,1938],[1446,1938],[1446,1983],[434,1983]],"region":{"top_left_x":433,"top_left_y":1937,"width":1013,"height":47},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0430a82f56b400d9aefaf8d3e8ee1d3","type":"text","conversion_output":true,"text":"at Day 90. These results will further describe the treatment effect.","text_display":" at Day 90. These results will further describe the treatment effect.","confidence":0.77978515625,"confidence_rate":0.9965984444983558},{"cnt":[[425,2022],[1063,2022],[1063,2071],[425,2071]],"region":{"top_left_x":425,"top_left_y":2021,"width":639,"height":51},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d1f54b83af74adebe6684b7f29876a2","type":"section_header","conversion_output":false,"children_ids":["b440def9afb74c6ca5ec66b68168a76f"],"text":"","text_display":""},{"cnt":[[434,2028],[1057,2028],[1057,2065],[434,2065]],"region":{"top_left_x":433,"top_left_y":2028,"width":625,"height":37},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b440def9afb74c6ca5ec66b68168a76f","type":"text","conversion_output":true,"parent_id":"2d1f54b83af74adebe6684b7f29876a2","text":"4.4.2.1 Ordinal Modified Rankin Scale","text_display":"\n\n\\subsection*{4.4.2.1 Ordinal Modified Rankin Scale}","confidence":1,"confidence_rate":1},{"cnt":[[434,2088],[1738,2088],[1738,2133],[434,2133]],"region":{"top_left_x":433,"top_left_y":2088,"width":1306,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a61a0a0c8684733b462c8ed17456e1e","type":"text","conversion_output":true,"text":"As a secondary endpoint, mRS at Day 90 will be further explored on the range of the","text_display":"\n\nAs a secondary endpoint, mRS at Day 90 will be further explored on the range of the","confidence":1,"confidence_rate":1},{"cnt":[[434,2140],[1742,2140],[1742,2185],[434,2185]],"region":{"top_left_x":433,"top_left_y":2139,"width":1310,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77001dd017b44bd9afe9e60a20ece779","type":"text","conversion_output":true,"text":"values ( 0 to 6 ) where the values of 5 and 6 are grouped. The distribution of full range","text_display":" values ( 0 to 6 ) where the values of 5 and 6 are grouped. The distribution of full range","confidence":0.9892956770490855,"confidence_rate":0.9998984766031952},{"cnt":[[434,2191],[1682,2191],[1682,2237],[434,2237]],"region":{"top_left_x":433,"top_left_y":2191,"width":1250,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8163d0fc29004b66a6bccce5208c9726","type":"text","conversion_output":true,"text":"of mRS scores at Day 90 (imputed) will be summarized by treatment group. Both","text_display":" of mRS scores at Day 90 (imputed) will be summarized by treatment group. Both","confidence":0.9839217431192537,"confidence_rate":0.9998218959234819},{"cnt":[[434,2243],[1308,2243],[1308,2288],[434,2288]],"region":{"top_left_x":433,"top_left_y":2242,"width":876,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b52fec3e8626404ebcee886b1ae035a9","type":"text","conversion_output":true,"text":"tabular displays and stacked bar charts will be prepared.","text_display":" tabular displays and stacked bar charts will be prepared.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"595529af33234613bfc1314d6716db6e","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2402],[434,2402]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":35},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1483944a805640e783c6c19913aa89b5","type":"text","conversion_output":true,"text":"15/ML29093","text_display":"\n15/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2402],[1044,2402]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":35},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd4a4ce022c24cb6a53f0da1334c99a9","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b17bab3e94504b168f19ecd7a39a5ac5","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9965858445502818,"confidence_rate":0.9999473860460373},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b71e667aadc54712b92969287c7b2ab1","type":"page_info","conversion_output":false,"text":"776/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-17","page":17,"lines":[{"cnt":[[434,447],[1652,447],[1652,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1220,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e496f75c655e45b5adc375f471c282e3","type":"text","conversion_output":true,"text":"The comparison will be achieved by fitting a proportional odds model with mRS","text_display":"\n\nThe comparison will be achieved by fitting a proportional odds model with mRS","confidence":0.8310546875,"confidence_rate":0.9977993336314985},{"cnt":[[434,498],[1656,498],[1656,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1224,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5793e708a71e4579bfb26c59509d24c1","type":"text","conversion_output":true,"text":"score at Day 90 as the dependent variable, and treatment group, pre-treatment","text_display":" score at Day 90 as the dependent variable, and treatment group, pre-treatment","confidence":1,"confidence_rate":1},{"cnt":[[434,550],[1592,550],[1592,595],[434,595]],"region":{"top_left_x":433,"top_left_y":550,"width":1159,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80c0bf76d7084362b8d6a0425bf1bee7","type":"text","conversion_output":true,"text":"NIHSS score, age, and last known well time to treatment as the continuous","text_display":" NIHSS score, age, and last known well time to treatment as the continuous","confidence":1,"confidence_rate":1},{"cnt":[[434,602],[1729,602],[1729,647],[434,647]],"region":{"top_left_x":433,"top_left_y":601,"width":1297,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11693c1a837a4b8694a3f706934977ec","type":"text","conversion_output":true,"text":"predictors \\((1,8)\\). Quadratic terms for the continuous covariates may be added to the","text_display":" predictors \\((1,8)\\). Quadratic terms for the continuous covariates may be added to the","confidence":0.9638845920562744,"confidence_rate":0.9996002569911191},{"cnt":[[434,653],[1721,653],[1721,698],[434,698]],"region":{"top_left_x":433,"top_left_y":653,"width":1288,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8887f28366e342e6984c1ae3436fc41f","type":"text","conversion_output":true,"text":"model, if the Wald p -value for the quadratic term is \\(<0.1\\). No interactions among the","text_display":" model, if the Wald p -value for the quadratic term is \\(<0.1\\). No interactions among the","confidence":0.7888451218605042,"confidence_rate":0.9976309578785517},{"cnt":[[434,707],[1708,707],[1708,752],[434,752]],"region":{"top_left_x":433,"top_left_y":706,"width":1276,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7336961408f42fbb0d97e1f1d7bebf0","type":"text","conversion_output":true,"text":"covariates will be included in this model. The adjusted odds ratio with its two-sided","text_display":" covariates will be included in this model. The adjusted odds ratio with its two-sided","confidence":1,"confidence_rate":1},{"cnt":[[434,756],[1717,756],[1717,804],[434,804]],"region":{"top_left_x":433,"top_left_y":756,"width":1284,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0134367ec47464784ef368d3d7b329b","type":"text","conversion_output":true,"text":"\\(95 \\% Cl\\) will be shown. Direction of the odds ratio will be chosen to reflect change in","text_display":" \\(95 \\% Cl\\) will be shown. Direction of the odds ratio will be chosen to reflect change in","confidence":0.7585134506225586,"confidence_rate":0.996967303030261},{"cnt":[[434,812],[1515,812],[1515,855],[434,855]],"region":{"top_left_x":433,"top_left_y":812,"width":1082,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4ed60cbbc5a4ae78e584d845ceae9c4","type":"text","conversion_output":true,"text":"the odds of achieving a lower (better) mRS if treated with IV alteplase.","text_display":" the odds of achieving a lower (better) mRS if treated with IV alteplase.","confidence":0.99658203125,"confidence_rate":0.9999555357502582},{"cnt":[[434,902],[1699,902],[1699,947],[434,947]],"region":{"top_left_x":433,"top_left_y":902,"width":1267,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d405305a63a148d295a52b5b3bd82966","type":"text","conversion_output":true,"text":"The proportional odds assumption will be tested by the score test, and the p -value","text_display":"\n\nThe proportional odds assumption will be tested by the score test, and the p -value","confidence":0.8891792297363281,"confidence_rate":0.9987512435849787},{"cnt":[[434,954],[1665,954],[1665,999],[434,999]],"region":{"top_left_x":433,"top_left_y":953,"width":1233,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38d76b91e79c494d9bc49a9f7712426d","type":"text","conversion_output":true,"text":"will be reported. If the proportional odds assumption does not hold, the resulting","text_display":" will be reported. If the proportional odds assumption does not hold, the resulting","confidence":1,"confidence_rate":1},{"cnt":[[434,1008],[1691,1008],[1691,1051],[434,1051]],"region":{"top_left_x":433,"top_left_y":1007,"width":1258,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3152c0517b734b2aaf69f58019d3cf07","type":"text","conversion_output":true,"text":"odds ratio will not be presented. The alternative analysis planned for this situation","text_display":" odds ratio will not be presented. The alternative analysis planned for this situation","confidence":1,"confidence_rate":1},{"cnt":[[434,1059],[1721,1059],[1721,1102],[434,1102]],"region":{"top_left_x":433,"top_left_y":1059,"width":1288,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"160b3b82bad444d88f3f9ef221f818ae","type":"text","conversion_output":true,"text":"will provide the adjusted mean difference between mRS scores with two-sided \\(95 \\%\\)","text_display":" will provide the adjusted mean difference between mRS scores with two-sided \\(95 \\%\\)","confidence":0.6295771598815918,"confidence_rate":0.9948145376884614},{"cnt":[[434,1113],[1704,1113],[1704,1158],[434,1158]],"region":{"top_left_x":433,"top_left_y":1112,"width":1271,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"231a6bd3c55848b28b445abd316bac46","type":"text","conversion_output":true,"text":"Cl . Methodology for this estimation is similar to the primary outcome, but using the","text_display":" Cl . Methodology for this estimation is similar to the primary outcome, but using the","confidence":0.7722389698028564,"confidence_rate":0.9971945813614154},{"cnt":[[434,1164],[1051,1164],[1051,1210],[434,1210]],"region":{"top_left_x":433,"top_left_y":1164,"width":618,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ebd5f7ca7e147f393419be97c500135","type":"text","conversion_output":true,"text":"ordinal mRS as the dependent variable.","text_display":" ordinal mRS as the dependent variable.","confidence":1,"confidence_rate":1},{"cnt":[[425,1246],[982,1246],[982,1300],[425,1300]],"region":{"top_left_x":425,"top_left_y":1246,"width":557,"height":54},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"62fae0173b4d466fa718860ef213ecd2","type":"section_header","conversion_output":false,"children_ids":["df7df07366314df5b0535d9527bb27ac"],"text":"","text_display":""},{"cnt":[[432,1250],[975,1250],[975,1291],[432,1291]],"region":{"top_left_x":431,"top_left_y":1250,"width":545,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df7df07366314df5b0535d9527bb27ac","type":"text","conversion_output":true,"parent_id":"62fae0173b4d466fa718860ef213ecd2","text":"4.4.2.2 Global Outcome Measure","text_display":"\n\n\\subsection*{4.4.2.2 Global Outcome Measure}","confidence":0.99951171875,"confidence_rate":0.9999860457974148},{"cnt":[[434,1315],[1742,1315],[1742,1360],[434,1360]],"region":{"top_left_x":433,"top_left_y":1314,"width":1310,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a789adf7d764703900d6a07dc957ce9","type":"text","conversion_output":true,"text":"Global outcome measure is derived from \\(mRS =0\\) or 1 , NIHSS \\(=0\\) or \\(1, BI \\geq 95\\), and","text_display":"\n\nGlobal outcome measure is derived from \\(mRS =0\\) or 1 , NIHSS \\(=0\\) or \\(1, BI \\geq 95\\), and","confidence":0.9624092322831276,"confidence_rate":0.9996169181806994},{"cnt":[[434,1366],[1712,1366],[1712,1412],[434,1412]],"region":{"top_left_x":433,"top_left_y":1366,"width":1280,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28aeb07c78084eaf92de0008433c381e","type":"text","conversion_output":true,"text":"GOS \\(=1\\) at Day 90, considered as a whole. If death occurs prior to Day 90, all four","text_display":" GOS \\(=1\\) at Day 90, considered as a whole. If death occurs prior to Day 90, all four","confidence":0.9673008918762207,"confidence_rate":0.9996306718654596},{"cnt":[[434,1418],[1566,1418],[1566,1463],[434,1463]],"region":{"top_left_x":433,"top_left_y":1417,"width":1134,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6429882c66742a88c540f4f959e8f96","type":"text","conversion_output":true,"text":"binary outcomes will be considered as not being achieved in the analysis.","text_display":" binary outcomes will be considered as not being achieved in the analysis.","confidence":1,"confidence_rate":1},{"cnt":[[434,1512],[1699,1512],[1699,1558],[434,1558]],"region":{"top_left_x":433,"top_left_y":1512,"width":1267,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6afad6fdfd44ca0a6068db0f627ea30","type":"text","conversion_output":true,"text":"The NIHSS score is the total from scoring 11 items, assessed by a clinician. Items","text_display":"\n\nThe NIHSS score is the total from scoring 11 items, assessed by a clinician. Items","confidence":1,"confidence_rate":1},{"cnt":[[434,1564],[1717,1564],[1717,1609],[434,1609]],"region":{"top_left_x":433,"top_left_y":1564,"width":1284,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12b789da741b4b45806cd1dfd9369121","type":"text","conversion_output":true,"text":"that are not applicable are not included in the total. It is not expected that any items","text_display":" that are not applicable are not included in the total. It is not expected that any items","confidence":1,"confidence_rate":1},{"cnt":[[434,1616],[1669,1616],[1669,1661],[434,1661]],"region":{"top_left_x":433,"top_left_y":1615,"width":1237,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b31d934df0946f88e7e97403752a583","type":"text","conversion_output":true,"text":"will be applicable but missing; in such cases, the total score will be missing. The","text_display":" will be applicable but missing; in such cases, the total score will be missing. The","confidence":1,"confidence_rate":1},{"cnt":[[434,1667],[1680,1667],[1680,1712],[434,1712]],"region":{"top_left_x":433,"top_left_y":1667,"width":1248,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef5dca81d7a7450dbc37528cdf888f2e","type":"text","conversion_output":true,"text":"total score ranges from 0 to 42 . NIHSS score will be collected pre-treatment, and","text_display":" total score ranges from 0 to 42 . NIHSS score will be collected pre-treatment, and","confidence":1,"confidence_rate":1},{"cnt":[[434,1719],[1659,1719],[1659,1764],[434,1764]],"region":{"top_left_x":433,"top_left_y":1718,"width":1226,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce5c4ad46f4a4e2f9178c76505f16c84","type":"text","conversion_output":true,"text":"then after 22-36 hours from start of study drug administration, after 5 days or at","text_display":" then after 22-36 hours from start of study drug administration, after 5 days or at","confidence":0.9907407662831247,"confidence_rate":0.9998966457094092},{"cnt":[[434,1770],[1044,1770],[1044,1815],[434,1815]],"region":{"top_left_x":433,"top_left_y":1770,"width":612,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bff2fb435bd4f978742845484a5ddb3","type":"text","conversion_output":true,"text":"discharge from hospital, and at Day 90.","text_display":" discharge from hospital, and at Day 90.","confidence":1,"confidence_rate":1},{"cnt":[[434,1865],[1721,1865],[1721,1910],[434,1910]],"region":{"top_left_x":433,"top_left_y":1864,"width":1288,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"902d43db75e14a8e81c2c7a881cd1ffe","type":"text","conversion_output":true,"text":"The Barthel index (BI) measures activities of daily living by having an assessor rate","text_display":"\n\nThe Barthel index (BI) measures activities of daily living by having an assessor rate","confidence":0.99074625025969,"confidence_rate":0.9998967072054237},{"cnt":[[434,1916],[1725,1916],[1725,1962],[434,1962]],"region":{"top_left_x":433,"top_left_y":1916,"width":1293,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e6618bb025147669b08bce6d40cd72c","type":"text","conversion_output":true,"text":"10 items, with possible scores of \\(0,5,10\\) or 15 . A total score, ranging from 0 to 100 ,","text_display":" 10 items, with possible scores of \\(0,5,10\\) or 15 . A total score, ranging from 0 to 100 ,","confidence":0.899127721786499,"confidence_rate":0.9989682007911552},{"cnt":[[434,1968],[1738,1968],[1738,2013],[434,2013]],"region":{"top_left_x":433,"top_left_y":1967,"width":1306,"height":47},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e93ef970dbb144fa9b1c862caf1e280c","type":"text","conversion_output":true,"text":"is computed as the sum of the ratings from the 10 items. As this is a rater-completed","text_display":" is computed as the sum of the ratings from the 10 items. As this is a rater-completed","confidence":0.9970703125,"confidence_rate":0.9999684522456539},{"cnt":[[434,2020],[1738,2020],[1738,2065],[434,2065]],"region":{"top_left_x":433,"top_left_y":2019,"width":1306,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e699a868ca39420ab2c20d9de686da7a","type":"text","conversion_output":true,"text":"assessment, no missing data are expected. However, if any item is not scored, then","text_display":" assessment, no missing data are expected. However, if any item is not scored, then","confidence":1,"confidence_rate":1},{"cnt":[[434,2071],[1725,2071],[1725,2116],[434,2116]],"region":{"top_left_x":433,"top_left_y":2071,"width":1293,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3697febe9af4328aa20b50f4bcdfd9a","type":"text","conversion_output":true,"text":"a score of 0 will be given as it will be presumed the subject did not meet the defined","text_display":" a score of 0 will be given as it will be presumed the subject did not meet the defined","confidence":1,"confidence_rate":1},{"cnt":[[434,2123],[810,2123],[810,2168],[434,2168]],"region":{"top_left_x":433,"top_left_y":2122,"width":377,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"374722882a95437db7d1a979e139278a","type":"text","conversion_output":true,"text":"criteria for the item (20).","text_display":" criteria for the item (20).","confidence":0.99951171875,"confidence_rate":0.9999847376009057},{"cnt":[[434,2217],[1734,2217],[1734,2262],[434,2262]],"region":{"top_left_x":433,"top_left_y":2217,"width":1301,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce1d69ce6c80492bbafd0af2af3dc343","type":"text","conversion_output":true,"text":"Glasgow Outcome Scale (GOS) is an evaluation of the outcome of stroke, assessed","text_display":"\n\nGlasgow Outcome Scale (GOS) is an evaluation of the outcome of stroke, assessed","confidence":0.9985356330871582,"confidence_rate":0.9999825544361526},{"cnt":[[434,2269],[1669,2269],[1669,2314],[434,2314]],"region":{"top_left_x":433,"top_left_y":2268,"width":1237,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9f9a99684b94ec68bf24ccaf4933f01","type":"text","conversion_output":true,"text":"on a scale ranging from 1 to 5 by a clinician. The scale will be reversed from the","text_display":" on a scale ranging from 1 to 5 by a clinician. The scale will be reversed from the","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ff5adc9df3f41809a3c1a881e131609","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2402],[434,2402]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":35},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4c0dfda8bd54b1ea1ce726540de642b","type":"text","conversion_output":true,"text":"16/ML29093","text_display":"\n16/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2402],[1044,2402]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":35},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee6d88c9e4064fb09d50101467a6853e","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af2fcc1dfeb0460084a4fde5190fdca7","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9970729344058782,"confidence_rate":0.9999549032041459},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae930a6c6caa4ee7ba2513e0f0724ca3","type":"page_info","conversion_output":false,"text":"777/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-18","page":18,"lines":[{"cnt":[[434,447],[1687,447],[1687,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1254,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6865a9479fe74cb699982519563ee988","type":"text","conversion_output":true,"text":"original published version (7) to assign lower scores to more favorable outcomes.","text_display":"\noriginal published version (7) to assign lower scores to more favorable outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[1216,498],[1216,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":784,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c73886fa1fda4efbb9dbba13c446ae5b","type":"text","conversion_output":true,"text":"The score is collected once in the study at Day 90.","text_display":" The score is collected once in the study at Day 90.","confidence":0.99951171875,"confidence_rate":0.9999911200303706},{"cnt":[[432,593],[1727,593],[1727,638],[432,638]],"region":{"top_left_x":431,"top_left_y":592,"width":1297,"height":47},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19ef86eea7974c35ba09ec2abe254bd7","type":"text","conversion_output":true,"text":"The observed proportion of patients with a favorable outcome within each treatment","text_display":"\n\nThe observed proportion of patients with a favorable outcome within each treatment","confidence":1,"confidence_rate":1},{"cnt":[[434,645],[1712,645],[1712,690],[434,690]],"region":{"top_left_x":433,"top_left_y":644,"width":1280,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3416342e2c6847e1950cbe80a525ec63","type":"text","conversion_output":true,"text":"group will be provided for the NIHSS ( \\(=0\\) or 1 ), BI ( \\(\\geq 95\\) ) and GOS ( \\(=1\\) ) components","text_display":" group will be provided for the NIHSS ( \\(=0\\) or 1 ), BI ( \\(\\geq 95\\) ) and GOS ( \\(=1\\) ) components","confidence":0.4038661928210755,"confidence_rate":0.9912359922894133},{"cnt":[[434,696],[1665,696],[1665,741],[434,741]],"region":{"top_left_x":433,"top_left_y":696,"width":1233,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6e9154bd5ae436ca45b68ff642545f8","type":"text","conversion_output":true,"text":"of the global outcome measure, in a similar fashion as described for the primary","text_display":" of the global outcome measure, in a similar fashion as described for the primary","confidence":1,"confidence_rate":1},{"cnt":[[434,752],[582,752],[582,788],[434,788]],"region":{"top_left_x":433,"top_left_y":751,"width":150,"height":38},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50ca71cbd6104045be03be2fff09a6d5","type":"text","conversion_output":true,"text":"outcome.","text_display":" outcome.","confidence":1,"confidence_rate":1},{"cnt":[[434,838],[1641,838],[1641,885],[434,885]],"region":{"top_left_x":433,"top_left_y":837,"width":1209,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f8a6d4e72f44e79b175debcc34a5f95","type":"text","conversion_output":true,"text":"Treatment comparisons will be performed considering the four binary outcome","text_display":"\n\nTreatment comparisons will be performed considering the four binary outcome","confidence":1,"confidence_rate":1},{"cnt":[[434,894],[1714,894],[1714,937],[434,937]],"region":{"top_left_x":433,"top_left_y":893,"width":1282,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a956fb24465412a9e05a9f1ffccb3ec","type":"text","conversion_output":true,"text":"measures as 4 dimensions of the outcome endpoint (12). These dimensions will be","text_display":" measures as 4 dimensions of the outcome endpoint (12). These dimensions will be","confidence":0.9965853681787848,"confidence_rate":0.9999606849684683},{"cnt":[[434,945],[1669,945],[1669,990],[434,990]],"region":{"top_left_x":433,"top_left_y":945,"width":1237,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f48895c40ffb41f6b006c43f335eb9fd","type":"text","conversion_output":true,"text":"assumed to have a common odds ratio adjusted for pre-treatment NIHSS score,","text_display":" assumed to have a common odds ratio adjusted for pre-treatment NIHSS score,","confidence":1,"confidence_rate":1},{"cnt":[[434,997],[1644,997],[1644,1042],[434,1042]],"region":{"top_left_x":433,"top_left_y":996,"width":1211,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de5249faae09430ab6481c2a63f808bb","type":"text","conversion_output":true,"text":"age, and last known well time to treatment. Quadratic terms for the continuous","text_display":" age, and last known well time to treatment. Quadratic terms for the continuous","confidence":1,"confidence_rate":1},{"cnt":[[434,1048],[1710,1048],[1710,1094],[434,1094]],"region":{"top_left_x":433,"top_left_y":1048,"width":1278,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39b1afe0f8a44acd8e22d76489783e4c","type":"text","conversion_output":true,"text":"covariates may be added to the model, if the Wald p -value for the quadratic term is","text_display":" covariates may be added to the model, if the Wald p -value for the quadratic term is","confidence":0.7729315757751465,"confidence_rate":0.997292464088406},{"cnt":[[434,1100],[1734,1100],[1734,1145],[434,1145]],"region":{"top_left_x":433,"top_left_y":1100,"width":1301,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b72eef6cd4db48e490cfd29d9ea3fa88","type":"text","conversion_output":true,"text":"<0.1. No interactions among the covariates will be included in this model. Estimation","text_display":" <0.1. No interactions among the covariates will be included in this model. Estimation","confidence":0.9878230094909668,"confidence_rate":0.9998638788489567},{"cnt":[[434,1154],[1687,1154],[1687,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1153,"width":1254,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75b6b36bcf9647798df6e5b8aa4840d3","type":"text","conversion_output":true,"text":"will be performed using generalized estimating equations for a logistic model with","text_display":" will be performed using generalized estimating equations for a logistic model with","confidence":1,"confidence_rate":1},{"cnt":[[434,1207],[1734,1207],[1734,1248],[434,1248]],"region":{"top_left_x":433,"top_left_y":1207,"width":1301,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eaecf43dd8c34f85a74100782528d852","type":"text","conversion_output":true,"text":"correlation between the four outcomes of the same patient. Details of this model can","text_display":" correlation between the four outcomes of the same patient. Details of this model can","confidence":1,"confidence_rate":1},{"cnt":[[434,1257],[1738,1257],[1738,1302],[434,1302]],"region":{"top_left_x":433,"top_left_y":1256,"width":1306,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db9948e755a0485c87a7b6a89744a7e2","type":"text","conversion_output":true,"text":"be found in Appendix D. The estimated common odds ratio and its two-sided 95\\% CI","text_display":" be found in Appendix D. The estimated common odds ratio and its two-sided 95\\% CI","confidence":0.3870172504102811,"confidence_rate":0.9888940606586559},{"cnt":[[434,1311],[685,1311],[685,1351],[434,1351]],"region":{"top_left_x":433,"top_left_y":1310,"width":253,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26edbfcedfe542c98abddf2be85c4b7b","type":"text","conversion_output":true,"text":"will be reported.","text_display":" will be reported.","confidence":1,"confidence_rate":1},{"cnt":[[434,1401],[1734,1401],[1734,1446],[434,1446]],"region":{"top_left_x":433,"top_left_y":1400,"width":1301,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a76d3dedaba1476596874fe7036967bf","type":"text","conversion_output":true,"text":"Each individual outcome measure will be evaluated separately: odds ratios with two-","text_display":"\n\nEach individual outcome measure will be evaluated separately: odds ratios with two","confidence":1,"confidence_rate":1},{"cnt":[[434,1452],[1661,1452],[1661,1497],[434,1497]],"region":{"top_left_x":433,"top_left_y":1452,"width":1228,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66419f9428b745d597293419b9cf5deb","type":"text","conversion_output":true,"text":"sided \\(95 \\%\\) Cls will be derived from a logistic model with the same covariates as","text_display":"sided \\(95 \\%\\) Cls will be derived from a logistic model with the same covariates as","confidence":0.951171875,"confidence_rate":0.9994247574470044},{"cnt":[[434,1504],[1618,1504],[1618,1549],[434,1549]],"region":{"top_left_x":433,"top_left_y":1503,"width":1185,"height":47},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"353e92ef53244296a311c5f4df3fd6ac","type":"text","conversion_output":true,"text":"used for the global outcome measure to facilitate interpretation of the results.","text_display":" used for the global outcome measure to facilitate interpretation of the results.","confidence":1,"confidence_rate":1},{"cnt":[[434,1598],[1618,1598],[1618,1644],[434,1644]],"region":{"top_left_x":433,"top_left_y":1598,"width":1185,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb7bf5dc05c644748a92f02589003c28","type":"text","conversion_output":true,"text":"LOCF and hot deck imputation will be used for the missing mRS component,","text_display":"\n\nLOCF and hot deck imputation will be used for the missing mRS component,","confidence":0.98583984375,"confidence_rate":0.9998281910518533},{"cnt":[[434,1650],[1648,1650],[1648,1695],[434,1695]],"region":{"top_left_x":433,"top_left_y":1650,"width":1215,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95d327b2656847b98afb636371ec7ef7","type":"text","conversion_output":true,"text":"similarly to the primary analysis. No imputation is planned for the other missing","text_display":" similarly to the primary analysis. No imputation is planned for the other missing","confidence":1,"confidence_rate":1},{"cnt":[[434,1702],[1644,1702],[1644,1747],[434,1747]],"region":{"top_left_x":433,"top_left_y":1701,"width":1211,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"128c8a5a95114292bfef4669baa776ad","type":"text","conversion_output":true,"text":"components, other than the non-achievement imputation in the event of death.","text_display":" components, other than the non-achievement imputation in the event of death.","confidence":1,"confidence_rate":1},{"cnt":[[434,1753],[1682,1753],[1682,1798],[434,1798]],"region":{"top_left_x":433,"top_left_y":1753,"width":1250,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"428ba4724f924a2b9d486d8144480fc5","type":"text","conversion_output":true,"text":"However, incomplete component sets can still contribute to the model and will be","text_display":" However, incomplete component sets can still contribute to the model and will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1805],[578,1805],[578,1846],[434,1846]],"region":{"top_left_x":433,"top_left_y":1804,"width":145,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca986e9faad94fc5a17ce225bc0d5898","type":"text","conversion_output":true,"text":"included.","text_display":" included.","confidence":1,"confidence_rate":1},{"cnt":[[301,1891],[958,1891],[958,1940],[301,1940]],"region":{"top_left_x":300,"top_left_y":1890,"width":659,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe0be9ae518141be942e9ce7b09965ed","type":"section_header","conversion_output":false,"children_ids":["a7cc3739824b44e1b2177e3f6b173bc7"],"text":"","text_display":""},{"cnt":[[305,1895],[956,1895],[956,1936],[305,1936]],"region":{"top_left_x":305,"top_left_y":1894,"width":652,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7cc3739824b44e1b2177e3f6b173bc7","type":"text","conversion_output":true,"parent_id":"fe0be9ae518141be942e9ce7b09965ed","text":"4.4.3 Exploratory Efficacy Endpoints","text_display":"\n\n\\subsection*{4.4.3 Exploratory Efficacy Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[425,1955],[1334,1955],[1334,2004],[425,2004]],"region":{"top_left_x":425,"top_left_y":1955,"width":910,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"731e033d5ab2487fbf1ced82e69a950e","type":"section_header","conversion_output":false,"children_ids":["03325f84f8234f5bacaf51a946fff934"],"text":"","text_display":""},{"cnt":[[432,1959],[1330,1959],[1330,2002],[432,2002]],"region":{"top_left_x":431,"top_left_y":1959,"width":899,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03325f84f8234f5bacaf51a946fff934","type":"text","conversion_output":true,"parent_id":"731e033d5ab2487fbf1ced82e69a950e","text":"4.4.3.1 Exploratory Analyses for the Primary Endpoint","text_display":"\n\n\\subsection*{4.4.3.1 Exploratory Analyses for the Primary Endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[434,2020],[1562,2020],[1562,2065],[434,2065]],"region":{"top_left_x":433,"top_left_y":2019,"width":1129,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"065fabbabe2d42898ebde6935083de7a","type":"text","conversion_output":true,"text":"The primary analysis of the \\(mRS 0-1\\) outcome will be complemented with","text_display":"\n\nThe primary analysis of the \\(mRS 0-1\\) outcome will be complemented with","confidence":0.9960982785560191,"confidence_rate":0.9999505157431658},{"cnt":[[434,2071],[1450,2071],[1450,2116],[434,2116]],"region":{"top_left_x":433,"top_left_y":2071,"width":1018,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"493984de09b3466b921b8fcad9b854cc","type":"text","conversion_output":true,"text":"exploratory supportive evaluations of treatment group differences.","text_display":" exploratory supportive evaluations of treatment group differences.","confidence":0.99951171875,"confidence_rate":0.9999931211434043},{"cnt":[[434,2166],[1706,2166],[1706,2211],[434,2211]],"region":{"top_left_x":433,"top_left_y":2165,"width":1273,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25fa640a9d2f4b7ca03bc8fbf93243c3","type":"text","conversion_output":true,"text":"The following analyses will be conducted to construct risk differences for mRS 0-1.","text_display":"\n\nThe following analyses will be conducted to construct risk differences for mRS 0-1.","confidence":0.9854013710282743,"confidence_rate":0.9998435629021188},{"cnt":[[434,2217],[1631,2217],[1631,2262],[434,2262]],"region":{"top_left_x":433,"top_left_y":2217,"width":1198,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7320df294a0b420984ee958cdca7c971","type":"text","conversion_output":true,"text":"Missing values for day 90 mRS will be imputed in the same manner as for the","text_display":" Missing values for day 90 mRS will be imputed in the same manner as for the","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[434,2269],[1244,2269],[1244,2314],[434,2314]],"region":{"top_left_x":433,"top_left_y":2268,"width":811,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"771a381f7b614bc08d257b004d669cce","type":"text","conversion_output":true,"text":"primary efficacy analysis unless otherwise specified.","text_display":" primary efficacy analysis unless otherwise specified.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f2c66b443404f7186542b48e71d5e58","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[599,2368],[599,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":167,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2eaec5f4348a46f4b36eba7e6d8fcbc6","type":"text","conversion_output":true,"text":"17/ML29093","text_display":"\n17/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e2913301d5440fe903613f5434b3758","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":44},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c85dde9531d4ce9aecd4453837ab55a","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9960999437631125,"confidence_rate":0.9999398836333983},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb68124d415a4b89bb9c931083c87301","type":"page_info","conversion_output":false,"text":"778/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-19","page":19,"lines":[{"cnt":[[486,443],[956,443],[956,483],[486,483]],"region":{"top_left_x":485,"top_left_y":442,"width":472,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9db3af9e6ebd4e0081beae29d7179ee6","type":"text","conversion_output":true,"text":"- Unadjusted risk difference.","text_display":"\n- Unadjusted risk difference.","confidence":0.9970715045928955,"confidence_rate":0.9999137451366386},{"cnt":[[486,505],[1704,505],[1704,548],[486,548]],"region":{"top_left_x":485,"top_left_y":504,"width":1219,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38759a2cfc5044ec94cc0860f1aa5744","type":"text","conversion_output":true,"text":"- Adjusted risk difference, from a linear regression with treatment, age, onset","text_display":"\n- Adjusted risk difference, from a linear regression with treatment, age, onset","confidence":1,"confidence_rate":1},{"cnt":[[537,546],[1706,546],[1706,591],[537,591]],"region":{"top_left_x":537,"top_left_y":545,"width":1169,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c18270d8a274409693f2f6ffa68c572a","type":"text","conversion_output":true,"text":"time to treatment, baseline NIHSS, and propensity score as covariates. The","text_display":" time to treatment, baseline NIHSS, and propensity score as covariates. The","confidence":1,"confidence_rate":1},{"cnt":[[537,591],[1729,591],[1729,634],[537,634]],"region":{"top_left_x":537,"top_left_y":590,"width":1193,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"626a4309187c42d480422d1744fd933e","type":"text","conversion_output":true,"text":"propensity score is derived from a logistic regression for treatment group with","text_display":" propensity score is derived from a logistic regression for treatment group with","confidence":1,"confidence_rate":1},{"cnt":[[537,634],[1721,634],[1721,677],[537,677]],"region":{"top_left_x":537,"top_left_y":633,"width":1184,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ac3e2cc8fa44fd8848dfbb7bb8860c9","type":"text","conversion_output":true,"text":"imbalanced covariates included in the model as covariates. This analysis will","text_display":" imbalanced covariates included in the model as covariates. This analysis will","confidence":1,"confidence_rate":1},{"cnt":[[537,679],[1656,679],[1656,720],[537,720]],"region":{"top_left_x":537,"top_left_y":678,"width":1120,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0980b1eb648410f9dc78d94ae065818","type":"text","conversion_output":true,"text":"be triggered by presence of baseline imbalance. The criteria for baseline","text_display":" be triggered by presence of baseline imbalance. The criteria for baseline","confidence":1,"confidence_rate":1},{"cnt":[[537,722],[1540,722],[1540,765],[537,765]],"region":{"top_left_x":537,"top_left_y":721,"width":1004,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6156d863f869442898c155ee5df40cda","type":"text","conversion_output":true,"text":"imbalance and details of this model are described in Appendix E.","text_display":" imbalance and details of this model are described in Appendix E.","confidence":1,"confidence_rate":1},{"cnt":[[434,793],[1671,793],[1671,836],[434,836]],"region":{"top_left_x":433,"top_left_y":792,"width":1239,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54f1233ef111431d83c8bb24d81975df","type":"text","conversion_output":true,"text":"The following analyses will be conducted to construct the odds ratio for mRS 0-1","text_display":"\n\nThe following analyses will be conducted to construct the odds ratio for mRS 0-1","confidence":0.9038553237915039,"confidence_rate":0.9988897818975293},{"cnt":[[434,842],[1729,842],[1729,887],[434,887]],"region":{"top_left_x":433,"top_left_y":842,"width":1297,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b4f3602097d4fd3bf1d793c82ce641b","type":"text","conversion_output":true,"text":"such that the direction of the odds ratio reflects change in the likelihood of achieving","text_display":" such that the direction of the odds ratio reflects change in the likelihood of achieving","confidence":1,"confidence_rate":1},{"cnt":[[434,896],[1173,896],[1173,939],[434,939]],"region":{"top_left_x":433,"top_left_y":895,"width":741,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dee4ca7157214c7d9bfd4eb59872318f","type":"text","conversion_output":true,"text":"a favorable outcome if treated with IV alteplase:","text_display":" a favorable outcome if treated with IV alteplase:","confidence":1,"confidence_rate":1},{"cnt":[[486,982],[1693,982],[1693,1025],[486,1025]],"region":{"top_left_x":485,"top_left_y":981,"width":1208,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a54a4eff67ae407cbb7c069370004d98","type":"text","conversion_output":true,"text":"- Logistic regression, adjusting for pre-treatment NIHSS score, age, and last","text_display":"\n- Logistic regression, adjusting for pre-treatment NIHSS score, age, and last","confidence":1,"confidence_rate":1},{"cnt":[[537,1025],[1695,1025],[1695,1063],[537,1063]],"region":{"top_left_x":537,"top_left_y":1024,"width":1159,"height":40},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd8c591782bc42adafcc55f82849dc19","type":"text","conversion_output":true,"text":"known well time to treatment as continuous covariates. Quadratic terms for","text_display":" known well time to treatment as continuous covariates. Quadratic terms for","confidence":1,"confidence_rate":1},{"cnt":[[537,1070],[1729,1070],[1729,1111],[537,1111]],"region":{"top_left_x":537,"top_left_y":1069,"width":1193,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ca9b95e272449b1968f45cb7cae851e","type":"text","conversion_output":true,"text":"the continuous covariates may be added to the model, if the Wald p-value for","text_display":" the continuous covariates may be added to the model, if the Wald p-value for","confidence":0.77197265625,"confidence_rate":0.9968099613787804},{"cnt":[[537,1113],[1648,1113],[1648,1154],[537,1154]],"region":{"top_left_x":537,"top_left_y":1112,"width":1111,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8af977993069403483b1c0d4161bd6c7","type":"text","conversion_output":true,"text":"the quadratic term is <0.1. No interactions will be included in this model.","text_display":" the quadratic term is <0.1. No interactions will be included in this model.","confidence":1,"confidence_rate":1},{"cnt":[[486,1177],[965,1177],[965,1218],[486,1218]],"region":{"top_left_x":485,"top_left_y":1177,"width":480,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca0bb8b2781e4b1aa69b9e54c5756e6b","type":"text","conversion_output":true,"text":"- Repeated measures model","text_display":"\n- Repeated measures model","confidence":1,"confidence_rate":1},{"cnt":[[537,1220],[1669,1220],[1669,1261],[537,1261]],"region":{"top_left_x":537,"top_left_y":1220,"width":1133,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c085092b8e4c415aa3e7c7da71711290","type":"text","conversion_output":true,"text":"mRS outcomes at Day 30 and Day 90 will be modeled jointly by a logistic","text_display":" mRS outcomes at Day 30 and Day 90 will be modeled jointly by a logistic","confidence":0.69580078125,"confidence_rate":0.9956915474904944},{"cnt":[[537,1263],[1695,1263],[1695,1306],[537,1306]],"region":{"top_left_x":537,"top_left_y":1263,"width":1159,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"96920eae4af54bcfb73850553faa5730","type":"text","conversion_output":true,"text":"regression, using the GEE approach to account for the correlation between","text_display":" regression, using the GEE approach to account for the correlation between","confidence":1,"confidence_rate":1},{"cnt":[[537,1306],[1740,1306],[1740,1349],[537,1349]],"region":{"top_left_x":537,"top_left_y":1306,"width":1204,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b4e9d1ffdc34f8190b60d4c71c5dac6","type":"text","conversion_output":true,"text":"Day 30 and Day 90 outcomes of the same subject. Detailed description of this","text_display":" Day 30 and Day 90 outcomes of the same subject. Detailed description of this","confidence":1,"confidence_rate":1},{"cnt":[[537,1349],[1729,1349],[1729,1394],[537,1394]],"region":{"top_left_x":537,"top_left_y":1349,"width":1193,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c0ef60f5cab47cf8a1dad9404092cb9","type":"text","conversion_output":true,"text":"model is provided in Appendix D. No imputation will be performed for missing","text_display":" model is provided in Appendix D. No imputation will be performed for missing","confidence":1,"confidence_rate":1},{"cnt":[[537,1392],[1033,1392],[1033,1435],[537,1435]],"region":{"top_left_x":537,"top_left_y":1392,"width":497,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bb325303e814216ab44aeb49a53c016","type":"text","conversion_output":true,"text":"mRS for this particular analysis.","text_display":" mRS for this particular analysis.","confidence":1,"confidence_rate":1},{"cnt":[[425,1474],[1096,1474],[1096,1528],[425,1528]],"region":{"top_left_x":425,"top_left_y":1473,"width":671,"height":55},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e3b6427f3217460ea650f07355963cad","type":"section_header","conversion_output":false,"children_ids":["1b5d536f41194cd49cc7c93d26672f3e"],"text":"","text_display":""},{"cnt":[[434,1478],[1089,1478],[1089,1523],[434,1523]],"region":{"top_left_x":433,"top_left_y":1478,"width":657,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1b5d536f41194cd49cc7c93d26672f3e","type":"text","conversion_output":true,"parent_id":"e3b6427f3217460ea650f07355963cad","text":"4.4.3.2 Additional Exploratory Analyses","text_display":"\n\n\\subsection*{4.4.3.2 Additional Exploratory Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[434,1543],[1687,1543],[1687,1583],[434,1583]],"region":{"top_left_x":433,"top_left_y":1542,"width":1254,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"958bd11fde3042ebb0111f43af9d6fdc","type":"text","conversion_output":true,"text":"To characterize treatment response among the subset of subjects with confirmed","text_display":"\n\nTo characterize treatment response among the subset of subjects with confirmed","confidence":1,"confidence_rate":1},{"cnt":[[434,1594],[1738,1594],[1738,1635],[434,1635]],"region":{"top_left_x":433,"top_left_y":1594,"width":1306,"height":41},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a9a2e04781047cea4711a159b66b8be","type":"text","conversion_output":true,"text":"strokes, adjusted risk difference for the primary efficacy outcome will be repeated on","text_display":" strokes, adjusted risk difference for the primary efficacy outcome will be repeated on","confidence":1,"confidence_rate":1},{"cnt":[[434,1646],[1742,1646],[1742,1687],[434,1687]],"region":{"top_left_x":433,"top_left_y":1645,"width":1310,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e2e2db7d39847448ec7a7e4674b66ad","type":"text","conversion_output":true,"text":"the subset of patients with stroke mimics excluded. In addition, analyses as specified","text_display":" the subset of patients with stroke mimics excluded. In addition, analyses as specified","confidence":1,"confidence_rate":1},{"cnt":[[434,1697],[1699,1697],[1699,1742],[434,1742]],"region":{"top_left_x":433,"top_left_y":1697,"width":1267,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c50fb0a67a5b45c585e73ae83e922bfe","type":"text","conversion_output":true,"text":"in section 4.4.2 for the secondary efficacy outcome measures will be produced for","text_display":" in section 4.4.2 for the secondary efficacy outcome measures will be produced for","confidence":1,"confidence_rate":1},{"cnt":[[434,1749],[724,1749],[724,1790],[434,1790]],"region":{"top_left_x":433,"top_left_y":1748,"width":292,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a679df9c7e3c48feaad8edb73fc00b2b","type":"text","conversion_output":true,"text":"confirmed strokes.","text_display":" confirmed strokes.","confidence":1,"confidence_rate":1},{"cnt":[[430,1835],[930,1835],[930,1880],[430,1880]],"region":{"top_left_x":429,"top_left_y":1834,"width":502,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b55474bbef4a462fb9a947060e6e9c34","type":"section_header","conversion_output":false,"children_ids":["a8be8f1844e2470ba039b07c384b1c7e"],"text":"","text_display":""},{"cnt":[[434,1839],[926,1839],[926,1876],[434,1876]],"region":{"top_left_x":433,"top_left_y":1839,"width":493,"height":37},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8be8f1844e2470ba039b07c384b1c7e","type":"text","conversion_output":true,"parent_id":"b55474bbef4a462fb9a947060e6e9c34","text":"4.4.3.3 Modified Rankin Scale","text_display":"\n\n\\subsection*{4.4.3.3 Modified Rankin Scale}","confidence":1,"confidence_rate":1},{"cnt":[[434,1899],[1704,1899],[1704,1944],[434,1944]],"region":{"top_left_x":433,"top_left_y":1899,"width":1271,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d017094f91d4637ab6d100a76128c18","type":"text","conversion_output":true,"text":"The mRS score will be used to evaluate the proportion of patients with a score \\(=0\\)","text_display":"\n\nThe mRS score will be used to evaluate the proportion of patients with a score \\(=0\\)","confidence":0.9585161209106445,"confidence_rate":0.9995345160883762},{"cnt":[[434,1951],[1738,1951],[1738,1996],[434,1996]],"region":{"top_left_x":433,"top_left_y":1950,"width":1306,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24fc0c271dfc472492a5b57ace577405","type":"text","conversion_output":true,"text":"vs 1 or higher. Observed percentages and adjusted risk difference will be presented.","text_display":" vs 1 or higher. Observed percentages and adjusted risk difference will be presented.","confidence":1,"confidence_rate":1},{"cnt":[[434,2002],[1648,2002],[1648,2047],[434,2047]],"region":{"top_left_x":433,"top_left_y":2002,"width":1215,"height":46},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e62234a60654de1806b4a9ecfb955f8","type":"text","conversion_output":true,"text":"The adjustment will be performed in the same way as for the primary endpoint.","text_display":" The adjustment will be performed in the same way as for the primary endpoint.","confidence":1,"confidence_rate":1},{"cnt":[[434,2054],[1708,2054],[1708,2099],[434,2099]],"region":{"top_left_x":433,"top_left_y":2053,"width":1276,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca95ce6bbcb54568861ed7d8e40bc158","type":"text","conversion_output":true,"text":"Adjusted odds ratio will be presented in a separate analysis for this outcome in the","text_display":" Adjusted odds ratio will be presented in a separate analysis for this outcome in the","confidence":1,"confidence_rate":1},{"cnt":[[434,2108],[900,2108],[900,2146],[434,2146]],"region":{"top_left_x":433,"top_left_y":2107,"width":468,"height":40},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43722c38bd0a45f8956f2552abdaef01","type":"text","conversion_output":true,"text":"same fashion as for mRS 0-1.","text_display":" same fashion as for mRS 0-1.","confidence":0.9970703125,"confidence_rate":0.9999110952421172},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"205487de851b435c935cff0dd76d4dac","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e9e432e5b2e4fb9b2f5462d104beafb","type":"page_info","conversion_output":false,"text":"18/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32969129b553402ebaaa6b4196fc4f65","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"818bd2c9d4f34b74a8441e76ed81d0f9","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9951250501919731,"confidence_rate":0.9999248201932889},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e39d756727344a0f95446461899e1ba4","type":"page_info","conversion_output":false,"text":"779/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-20","page":20,"lines":[{"cnt":[[430,438],[1240,438],[1240,488],[430,488]],"region":{"top_left_x":429,"top_left_y":438,"width":811,"height":50},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f68617be5bf8449f9f6857a6993fa8a6","type":"section_header","conversion_output":false,"children_ids":["32e23a81362043fe96566a3a3236bd93"],"text":"","text_display":""},{"cnt":[[434,443],[1235,443],[1235,483],[434,483]],"region":{"top_left_x":433,"top_left_y":442,"width":803,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32e23a81362043fe96566a3a3236bd93","type":"text","conversion_output":true,"parent_id":"f68617be5bf8449f9f6857a6993fa8a6","text":"4.4.3.4 National Institutes of Health Stroke Scale","text_display":"\n\n\\subsection*{4.4.3.4 National Institutes of Health Stroke Scale}","confidence":0.9980480668600649,"confidence_rate":0.9999644762556369},{"cnt":[[434,503],[1729,503],[1729,552],[434,552]],"region":{"top_left_x":433,"top_left_y":502,"width":1297,"height":51},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c17c98e535748c4903f59e43ae2b43d","type":"text","conversion_output":true,"text":"Descriptive statistics ( n , mean, standard deviation, median, quartiles, minimum, and","text_display":"\n\nDescriptive statistics ( n , mean, standard deviation, median, quartiles, minimum, and","confidence":0.8862249851226807,"confidence_rate":0.9987555746611545},{"cnt":[[434,554],[1663,554],[1663,604],[434,604]],"region":{"top_left_x":433,"top_left_y":554,"width":1230,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"694185a7d5d44e5a9a126aa9a33759bf","type":"text","conversion_output":true,"text":"maximum) will be provided for NIHSS score by treatment group, both at Day 5 /","text_display":" maximum) will be provided for NIHSS score by treatment group, both at Day 5 /","confidence":0.99609375,"confidence_rate":0.9999539551857287},{"cnt":[[434,606],[1687,606],[1687,655],[434,655]],"region":{"top_left_x":433,"top_left_y":605,"width":1254,"height":51},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9c9c9044a334434b8539007c0c381d4","type":"text","conversion_output":true,"text":"Hospital discharge and at Day 90. Reasons for not performing the assessment of","text_display":" Hospital discharge and at Day 90. Reasons for not performing the assessment of","confidence":1,"confidence_rate":1},{"cnt":[[434,657],[1021,657],[1021,707],[434,707]],"region":{"top_left_x":433,"top_left_y":657,"width":588,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cfa345ffbe9416fa6310199de5e3d30","type":"text","conversion_output":true,"text":"NIHSS at Day 90 will be summarized.","text_display":" NIHSS at Day 90 will be summarized.","confidence":0.99169921875,"confidence_rate":0.999806171703899},{"cnt":[[432,752],[1732,752],[1732,801],[432,801]],"region":{"top_left_x":431,"top_left_y":751,"width":1301,"height":51},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2d5e96536f94d0085b94bcc763dda51","type":"text","conversion_output":true,"text":"The NIHSS score will be used to evaluate the proportion of patients with a score \\(=0\\)","text_display":"\n\nThe NIHSS score will be used to evaluate the proportion of patients with a score \\(=0\\)","confidence":1,"confidence_rate":1},{"cnt":[[434,804],[1639,804],[1639,853],[434,853]],"region":{"top_left_x":433,"top_left_y":803,"width":1207,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"301bddc720ee4bcd8f3ccd2eb09b8b1c","type":"text","conversion_output":true,"text":"vs 1 or higher, and separately, 0-1 vs. 2 or higher. Observed percentages and","text_display":" vs 1 or higher, and separately, 0-1 vs. 2 or higher. Observed percentages and","confidence":0.99462890625,"confidence_rate":0.999938802214336},{"cnt":[[434,855],[1695,855],[1695,904],[434,904]],"region":{"top_left_x":433,"top_left_y":855,"width":1263,"height":50},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5559f30694d646aba246750704844508","type":"text","conversion_output":true,"text":"adjusted risk difference will be presented. The adjustment will be performed in the","text_display":" adjusted risk difference will be presented. The adjustment will be performed in the","confidence":1,"confidence_rate":1},{"cnt":[[434,907],[1674,907],[1674,956],[434,956]],"region":{"top_left_x":433,"top_left_y":906,"width":1241,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32af4e18008743c7b704fc40af1675ef","type":"text","conversion_output":true,"text":"same way as for the primary endpoint. Adjusted odds ratio will be presented in a","text_display":" same way as for the primary endpoint. Adjusted odds ratio will be presented in a","confidence":1,"confidence_rate":1},{"cnt":[[434,958],[1532,958],[1532,1008],[434,1008]],"region":{"top_left_x":433,"top_left_y":958,"width":1099,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e9191916f0843adb1135f616c817375","type":"text","conversion_output":true,"text":"separate analysis for this outcome in the same fashion as for mRS 0-1.","text_display":" separate analysis for this outcome in the same fashion as for mRS 0-1.","confidence":0.8177877312991768,"confidence_rate":0.9975197171299001},{"cnt":[[425,1044],[784,1044],[784,1098],[425,1098]],"region":{"top_left_x":425,"top_left_y":1044,"width":360,"height":54},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd6ed234669a4216bd799b56b3c8aa20","type":"section_header","conversion_output":false,"children_ids":["3c1497cde0f6419ba6d4bc3cf2a4d877"],"text":"","text_display":""},{"cnt":[[432,1048],[780,1048],[780,1089],[432,1089]],"region":{"top_left_x":431,"top_left_y":1048,"width":349,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c1497cde0f6419ba6d4bc3cf2a4d877","type":"text","conversion_output":true,"parent_id":"dd6ed234669a4216bd799b56b3c8aa20","text":"4.4.3.5 Barthel Index","text_display":"\n\n\\subsection*{4.4.3.5 Barthel Index}","confidence":1,"confidence_rate":1},{"cnt":[[434,1113],[1699,1113],[1699,1158],[434,1158]],"region":{"top_left_x":433,"top_left_y":1112,"width":1267,"height":47},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9927534ee22248448be96ad7a698d8ad","type":"text","conversion_output":true,"text":"The BI total score will be used to evaluate the proportion of patients with complete","text_display":"\n\nThe BI total score will be used to evaluate the proportion of patients with complete","confidence":1,"confidence_rate":1},{"cnt":[[434,1162],[1652,1162],[1652,1210],[434,1210]],"region":{"top_left_x":433,"top_left_y":1162,"width":1220,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6adf0d73d1541cd8bb18eed71cda712","type":"text","conversion_output":true,"text":"independence (defined as a score \\(=100\\) ) and will be summarized by treatment","text_display":" independence (defined as a score \\(=100\\) ) and will be summarized by treatment","confidence":0.9990236759185791,"confidence_rate":0.9999882313825493},{"cnt":[[434,1216],[1687,1216],[1687,1265],[434,1265]],"region":{"top_left_x":433,"top_left_y":1216,"width":1254,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe9caf88cb8f4a3d8801e4283be4bee4","type":"text","conversion_output":true,"text":"group. Observed percentages and adjusted risk difference will be presented. The","text_display":" group. Observed percentages and adjusted risk difference will be presented. The","confidence":1,"confidence_rate":1},{"cnt":[[434,1268],[1717,1268],[1717,1317],[434,1317]],"region":{"top_left_x":433,"top_left_y":1267,"width":1284,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1304d7347cb4b309c6233bb0bbc360f","type":"text","conversion_output":true,"text":"adjustment will be performed in the same way as for the primary endpoint.Reasons","text_display":" adjustment will be performed in the same way as for the primary endpoint.Reasons","confidence":1,"confidence_rate":1},{"cnt":[[434,1319],[1364,1319],[1364,1366],[434,1366]],"region":{"top_left_x":433,"top_left_y":1319,"width":932,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"842e7e035a9b43719866efa3673c5d97","type":"text","conversion_output":true,"text":"for not performing the assessment of BI will be summarized.","text_display":" for not performing the assessment of BI will be summarized.","confidence":1,"confidence_rate":1},{"cnt":[[425,1401],[969,1401],[969,1459],[425,1459]],"region":{"top_left_x":425,"top_left_y":1400,"width":544,"height":59},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84f60569b433440ca0da8de7e026f20c","type":"section_header","conversion_output":false,"children_ids":["cc053292a4b14b00b198f758f1c66915"],"text":"","text_display":""},{"cnt":[[432,1405],[965,1405],[965,1454],[432,1454]],"region":{"top_left_x":431,"top_left_y":1405,"width":534,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc053292a4b14b00b198f758f1c66915","type":"text","conversion_output":true,"parent_id":"84f60569b433440ca0da8de7e026f20c","text":"4.4.3.6 Glasgow Outcome Scale","text_display":"\n\n\\subsection*{4.4.3.6 Glasgow Outcome Scale}","confidence":0.99560546875,"confidence_rate":0.999870472636895},{"cnt":[[434,1470],[1738,1470],[1738,1519],[434,1519]],"region":{"top_left_x":433,"top_left_y":1469,"width":1306,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e02303ed2f94ab6a49923d5ede4e042","type":"text","conversion_output":true,"text":"Raw GOS score will be summarized by treatment group, and include the percentage","text_display":"\n\nRaw GOS score will be summarized by treatment group, and include the percentage","confidence":1,"confidence_rate":1},{"cnt":[[434,1521],[1609,1521],[1609,1571],[434,1571]],"region":{"top_left_x":433,"top_left_y":1521,"width":1177,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34550069da934bbd9cba4c2a86ac24ec","type":"text","conversion_output":true,"text":"of patients having each GOS score, and the proportion of patients with good","text_display":" of patients having each GOS score, and the proportion of patients with good","confidence":1,"confidence_rate":1},{"cnt":[[434,1573],[1729,1573],[1729,1622],[434,1622]],"region":{"top_left_x":433,"top_left_y":1572,"width":1297,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c46d527722b4c38b44063b0adb16235","type":"text","conversion_output":true,"text":"recovery. Observed percentages and adjusted risk difference will be presented. The","text_display":" recovery. Observed percentages and adjusted risk difference will be presented. The","confidence":1,"confidence_rate":1},{"cnt":[[434,1624],[1727,1624],[1727,1674],[434,1674]],"region":{"top_left_x":433,"top_left_y":1624,"width":1295,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d71a0f15b9714a479468fd6d5028c78c","type":"text","conversion_output":true,"text":"adjustment will be performed in the same way as for the primary endpoint. Reasons","text_display":" adjustment will be performed in the same way as for the primary endpoint. Reasons","confidence":1,"confidence_rate":1},{"cnt":[[434,1676],[1407,1676],[1407,1725],[434,1725]],"region":{"top_left_x":433,"top_left_y":1675,"width":975,"height":51},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b82496fdd144fe6b1df25b34a46f501","type":"text","conversion_output":true,"text":"for not performing the assessment of GOS will be summarized.","text_display":" for not performing the assessment of GOS will be summarized.","confidence":1,"confidence_rate":1},{"cnt":[[296,1760],[776,1760],[776,1820],[296,1820]],"region":{"top_left_x":296,"top_left_y":1759,"width":480,"height":61},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d6f761d955445a7879e3043b431ecf4","type":"section_header","conversion_output":false,"children_ids":["9c90dea79b3d416c9e2fabf57790f4f2"],"text":"","text_display":""},{"cnt":[[303,1766],[767,1766],[767,1813],[303,1813]],"region":{"top_left_x":302,"top_left_y":1766,"width":465,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c90dea79b3d416c9e2fabf57790f4f2","type":"text","conversion_output":true,"parent_id":"3d6f761d955445a7879e3043b431ecf4","text":"4.4.4 Subgroup Analyses","text_display":"\n\n\\subsection*{4.4.4 Subgroup Analyses}","confidence":0.9970703125,"confidence_rate":0.999895220224256},{"cnt":[[434,1835],[1605,1835],[1605,1880],[434,1880]],"region":{"top_left_x":433,"top_left_y":1834,"width":1172,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6137443877b34ff68cc8a37a656fb7ff","type":"text","conversion_output":true,"text":"For the primary endpoint, consistency of treatment effect of alteplase will be","text_display":"\n\nFor the primary endpoint, consistency of treatment effect of alteplase will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1886],[1691,1886],[1691,1936],[434,1936]],"region":{"top_left_x":433,"top_left_y":1886,"width":1258,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c77cce461b8641c5a9e83e7b9ea45940","type":"text","conversion_output":true,"text":"evaluated by various pre-specified baseline covariates. The primary pre-specified","text_display":" evaluated by various pre-specified baseline covariates. The primary pre-specified","confidence":1,"confidence_rate":1},{"cnt":[[434,1938],[1263,1938],[1263,1987],[434,1987]],"region":{"top_left_x":433,"top_left_y":1937,"width":831,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dfca44e068249d7be3f5f4e76957a28","type":"text","conversion_output":true,"text":"variables and their analytic thresholds are defined by:","text_display":" variables and their analytic thresholds are defined by:","confidence":1,"confidence_rate":1},{"cnt":[[434,2024],[887,2024],[887,2073],[434,2073]],"region":{"top_left_x":433,"top_left_y":2023,"width":455,"height":51},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76f32fbd692e4280bce3004cff7955fc","type":"text","conversion_output":true,"text":"- Age group (< 65 vs. \\(\\geq 65\\) )","text_display":"\n- Age group (< 65 vs. \\(\\geq 65\\) )","confidence":0.9917149459943175,"confidence_rate":0.9997810880221112},{"cnt":[[434,2088],[1214,2088],[1214,2138],[434,2138]],"region":{"top_left_x":433,"top_left_y":2088,"width":781,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"24dd405f4025410b8407da9d23cc3218","type":"text","conversion_output":true,"text":"- Pre-treatment NIHSS score group (0-2 vs. 3-5)","text_display":"\n- Pre-treatment NIHSS score group (0-2 vs. 3-5)","confidence":1,"confidence_rate":1},{"cnt":[[434,2153],[1497,2153],[1497,2202],[434,2202]],"region":{"top_left_x":433,"top_left_y":2152,"width":1065,"height":51},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00fc428744594c2ab053face1e797b71","type":"text","conversion_output":true,"text":"- Last known well time to treatment group (0-2 hours vs. \\(>2\\) hours)","text_display":"\n- Last known well time to treatment group (0-2 hours vs. \\(>2\\) hours)","confidence":0.6626319885253906,"confidence_rate":0.9944541446342237},{"cnt":[[434,2213],[1079,2213],[1079,2262],[434,2262]],"region":{"top_left_x":433,"top_left_y":2212,"width":646,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf6aa3a9a2e34f76942d13db0f241a33","type":"text","conversion_output":true,"text":"- Stroke subgroup (RISS vs. non-RISS)","text_display":"\n- Stroke subgroup (RISS vs. non-RISS)","confidence":1,"confidence_rate":1},{"cnt":[[430,2329],[1205,2329],[1205,2376],[430,2376]],"region":{"top_left_x":429,"top_left_y":2328,"width":777,"height":49},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d258fda20164124a69df808ee3935a6","type":"section_header","conversion_output":false,"children_ids":["69a67d9f61ea47d7a3b67dcb2e1e11b3"],"text":"","text_display":""},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69a67d9f61ea47d7a3b67dcb2e1e11b3","type":"text","conversion_output":true,"parent_id":"3d258fda20164124a69df808ee3935a6","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\n\\section*{Statistical Analysis Plan: Alteplase-Genentech USMA}","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce29a548934e4c829ec8690df3fd1760","type":"text","conversion_output":true,"text":"19/ML29093","text_display":"\n\n19/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2404],[1044,2404]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da853d5dceca4db892168442b397f3f8","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"69b0257ff43d46149dd5950ebbccc282","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931764525842368,"confidence_rate":0.9998946680975843},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93a1cd4d672f4c60be651b2aedfc98d4","type":"page_info","conversion_output":false,"text":"780/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-21","page":21,"lines":[{"cnt":[[434,447],[1605,447],[1605,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1172,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c01002e9ea14bb9b4b831a17961645b","type":"text","conversion_output":true,"text":"Adjusted odds ratios by subgroup will be obtained from multivariable logistic","text_display":"\n\nAdjusted odds ratios by subgroup will be obtained from multivariable logistic","confidence":1,"confidence_rate":1},{"cnt":[[434,501],[1596,501],[1596,544],[434,544]],"region":{"top_left_x":433,"top_left_y":500,"width":1164,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f46050a95b0436dabac19ce99422437","type":"text","conversion_output":true,"text":"regressions with the main effects for treatment, age, last known well time to","text_display":" regressions with the main effects for treatment, age, last known well time to","confidence":1,"confidence_rate":1},{"cnt":[[434,552],[1540,552],[1540,595],[434,595]],"region":{"top_left_x":433,"top_left_y":552,"width":1108,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4c987fda1f4426e854dd932322e1947","type":"text","conversion_output":true,"text":"treatment, and NIHSS, and fit separately for each level of the subgroup.","text_display":" treatment, and NIHSS, and fit separately for each level of the subgroup.","confidence":1,"confidence_rate":1},{"cnt":[[434,645],[1712,645],[1712,690],[434,690]],"region":{"top_left_x":433,"top_left_y":644,"width":1280,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dd2f76c8b93481080cb6e78a000b570","type":"text","conversion_output":true,"text":"Interactions of IV alteplase treatment effect with each of the subgroup variables will","text_display":"\n\nInteractions of IV alteplase treatment effect with each of the subgroup variables will","confidence":1,"confidence_rate":1},{"cnt":[[434,696],[1695,696],[1695,741],[434,741]],"region":{"top_left_x":433,"top_left_y":696,"width":1263,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd5746fe446a46479a5f0cc68f8aeb91","type":"text","conversion_output":true,"text":"be explored by adding interactions of the subgroup variables with treatment to the","text_display":" be explored by adding interactions of the subgroup variables with treatment to the","confidence":1,"confidence_rate":1},{"cnt":[[434,748],[1729,748],[1729,793],[434,793]],"region":{"top_left_x":433,"top_left_y":747,"width":1297,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5453c429d3aa4f03a79b386e9149bf77","type":"text","conversion_output":true,"text":"logistic regression. The interactions will be included one at a time; thus, there will be","text_display":" logistic regression. The interactions will be included one at a time; thus, there will be","confidence":1,"confidence_rate":1},{"cnt":[[434,799],[1682,799],[1682,844],[434,844]],"region":{"top_left_x":433,"top_left_y":799,"width":1250,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5e93768373e4045b93816a765c1a587","type":"text","conversion_output":true,"text":"4 separate models to test each interaction. Results from these models will not be","text_display":" 4 separate models to test each interaction. Results from these models will not be","confidence":1,"confidence_rate":1},{"cnt":[[434,851],[1729,851],[1729,896],[434,896]],"region":{"top_left_x":433,"top_left_y":850,"width":1297,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35aaac5af93f4740bcbf5023e71dca22","type":"text","conversion_output":true,"text":"reported, except when the interaction \\(p\\)-values is smaller than 0.1 , in which case the","text_display":" reported, except when the interaction \\(p\\)-values is smaller than 0.1 , in which case the","confidence":0.9975605006329715,"confidence_rate":0.9999750770473803},{"cnt":[[434,904],[1098,904],[1098,947],[434,947]],"region":{"top_left_x":433,"top_left_y":904,"width":665,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f969a9377bab4f66906410e153e5334a","type":"text","conversion_output":true,"text":"p -values will be footnoted in the forest plot.","text_display":" p -values will be footnoted in the forest plot.","confidence":0.9150390625,"confidence_rate":0.9983571190946419},{"cnt":[[434,997],[1729,997],[1729,1042],[434,1042]],"region":{"top_left_x":433,"top_left_y":996,"width":1297,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d070676d934b4fb38432e441a653c5c6","type":"text","conversion_output":true,"text":"A forest plot will be constructed to visually illustrate the subgroup analyses. The plot","text_display":"\n\nA forest plot will be constructed to visually illustrate the subgroup analyses. The plot","confidence":1,"confidence_rate":1},{"cnt":[[434,1048],[1729,1048],[1729,1094],[434,1094]],"region":{"top_left_x":433,"top_left_y":1048,"width":1297,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"360f3d2eb9f045e9a1f8207074ac5fd7","type":"text","conversion_output":true,"text":"will show the odds ratios described above with two-sided \\(95 \\% Cls\\), corresponding to","text_display":" will show the odds ratios described above with two-sided \\(95 \\% Cls\\), corresponding to","confidence":0.8689207723364234,"confidence_rate":0.9984903521831078},{"cnt":[[434,1102],[1635,1102],[1635,1145],[434,1145]],"region":{"top_left_x":433,"top_left_y":1102,"width":1202,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccca2d451ad04b2aa0fa7086e9d363f6","type":"text","conversion_output":true,"text":"each level of these subgroups. The plot will also show the common odds ratio","text_display":" each level of these subgroups. The plot will also show the common odds ratio","confidence":1,"confidence_rate":1},{"cnt":[[434,1154],[1729,1154],[1729,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1153,"width":1297,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"010c3345942c417abde69e2c08b009c8","type":"text","conversion_output":true,"text":"estimate in different color or line pattern, as a reference. A subgroup analysis will be","text_display":" estimate in different color or line pattern, as a reference. A subgroup analysis will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1205],[1729,1205],[1729,1248],[434,1248]],"region":{"top_left_x":433,"top_left_y":1205,"width":1297,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8473c01532414c2eba5937e4d4270605","type":"text","conversion_output":true,"text":"conducted only if there is at least 10 subjects per outcome ( \\(mRS 0-1, mRS >1\\) ), and","text_display":" conducted only if there is at least 10 subjects per outcome ( \\(mRS 0-1, mRS >1\\) ), and","confidence":0.8740315584503208,"confidence_rate":0.9986270780564287},{"cnt":[[434,1259],[1611,1259],[1611,1298],[434,1298]],"region":{"top_left_x":433,"top_left_y":1258,"width":1179,"height":40},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd0280c0e5da44e6a5ed9cb80ee936ec","type":"text","conversion_output":true,"text":"the standard error of the odds ratio estimate is stable with the addition of the","text_display":" the standard error of the odds ratio estimate is stable with the addition of the","confidence":1,"confidence_rate":1},{"cnt":[[434,1311],[608,1311],[608,1347],[434,1347]],"region":{"top_left_x":433,"top_left_y":1310,"width":176,"height":38},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"919cbad642904aec91ae4c4bc7717eca","type":"text","conversion_output":true,"text":"covariates.","text_display":" covariates.","confidence":1,"confidence_rate":1},{"cnt":[[434,1401],[1364,1401],[1364,1446],[434,1446]],"region":{"top_left_x":433,"top_left_y":1400,"width":932,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c84c8f7c3c2481f9caffe9f7b661c37","type":"text","conversion_output":true,"text":"Analysis of the efficacy endpoints is summarized in Table 2.","text_display":"\n\nAnalysis of the efficacy endpoints is summarized in Table 2.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"299189872f224ce3845b325d3b7666ac","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75af152135b14d1ea45e19c8152a99d4","type":"text","conversion_output":true,"text":"20/ML29093","text_display":"\n20/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"528c0aa985364ab795389222a786cfd6","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c5d6b4457454fd1aac21cb72452d887","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9960987546946853,"confidence_rate":0.9999398652695066},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0ca806b12c046d394bae19abe62abb5","type":"page_info","conversion_output":false,"text":"781/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-22","page":22,"lines":[{"cnt":[[846,443],[1330,443],[1330,544],[846,544]],"region":{"top_left_x":846,"top_left_y":442,"width":484,"height":102},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ad0bce9fd564337a1a537c427509e1b","type":"figure_label","conversion_output":false,"children_ids":["904cf8cddb7d492b937137ce7bdc2625","581f709d5134485cad995b397b007b5c"],"text":"","text_display":""},{"cnt":[[1023,451],[1154,451],[1154,483],[1023,483]],"region":{"top_left_x":1022,"top_left_y":451,"width":132,"height":33},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"904cf8cddb7d492b937137ce7bdc2625","type":"text","conversion_output":false,"parent_id":"7ad0bce9fd564337a1a537c427509e1b","text":"Table 2","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[851,498],[1326,498],[1326,539],[851,539]],"region":{"top_left_x":850,"top_left_y":498,"width":476,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"581f709d5134485cad995b397b007b5c","type":"text","conversion_output":false,"parent_id":"7ad0bce9fd564337a1a537c427509e1b","text":"Summary of Efficacy Analyses","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,554],[1747,554],[1747,2284],[434,2284]],"region":{"top_left_x":433,"top_left_y":554,"width":1314,"height":1730},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","type":"table","conversion_output":true,"children_ids":["bae5ef76784f47ae91219385a342f142","8648d567ca88475f94087bec9a382529","c95d7588808242378be199da5907c0d5","e6edaf0f44864ff1bf410777f57324c9","5f4473e7a17b460989a770072591a042","4ba346748b3d48bd80ff623b6903bc28","608492aad4a947f2acd641cbe653f5ab","9c65ea5271ac4a669067186e189746b8","2bda32a6ffbb40eba30edf1b34c5d27d","3348f853735d4da5bc160312e499ef86","c67d626444ec41f6b4dde6324da14594","a615639be1774e3ba10b93ddc4d9b8de","a518693ab43c42f7840fb3237050ebba","4f4b3a978cf44ccf9bdd5842fc2e5467","d0960dc8c69d4caab3fc470afece00f1","fddae43cfa0540a0aab1d3995a1c3c64","8f88f7f1a1194e80b5e38807f6262f03","72ba6840108a4cc78eac56bfff7ba615","d9fee37b7a2f4732b77c8860fc6dbe4c","bc63babbfbd24ecf8fde57d614a68a2c","1eed505eb1e14b4b989a8d431236c36b","13cdf1219d4d4abbbc2862b0096ce703","67cb14f19dbe4be09db569758f7ecb4f","d0af5d3eaf8149d9be430eac28ce3d0a","332266fcf7f14d3399014d4aa8d6519e","4d14bf58742b455aa4fdc3160e48b774","7537bea6c1ff48cca148b629b5e8ced8","ab865368c12340caa8ddf5458f098d4b","107baf128eeb40eabafbfc6467ad0d02","a371ab7c357c4577b0d4d45e6c9c3c8a","7e88f224c09b40faa5051dc262303e59","98f35176a85348aeaf9ab817955a6dc4","4524c34da0a34f1488495d54cc7b1965","03fe6f7b3cca4e64bd6db5d18590ca5c","ea03f1b43252464ead7751b64767f734","76e81a23292f4409b70e8fea75aa2c77","d83afea384024e4a9e2ceb83387242b6","dd803cc10e384ca7bd8ba1eeea91eebc","7d03323743e24685ab1d0e41913f9655","68101b004af64ab1b96bd1d6c1702e2f","3ebe5ce58f6d4524ad065aca252c9c71","5259e21167254d1fbb2ee9e6beca165e","a4d051723e844ee08b1587b004717ca0","aee7f3de1537433ea07b8d90320077a1","85334165d1304b68b880684131742c6e","3ae166aa46174deab98893af3fc93b70","7cd9dc1568a44f398bc628005f642a6a","dd54a3146dde429382780b8b624ae733","5d21d7b0fca1497b82a77d15b1ef69ce","d25326b5faf24a3c887d2c7cd830a2de","aa3225d8d926476faa0b42f784c19cbf","b2a362f7f66b4379a5e9591ff61b828b","92c9f97205cf43a5bc75a199f4030d93","f1c348e9ad814d6d8a814ee907891782","7868009326564a42bd55ed5443857b52","465f59a675264faab32467788bcd2d11","fe1cda865f6e454694eb6e34235d3947","a10f92de3c0d4af4a014f3eb9d542e23","50153c1d8b7d461ba3855f36e82a8cf0"],"selected_labels":["7ad0bce9fd564337a1a537c427509e1b"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline Analysis & Statistical Method & Missing Data Method & Analysis Set(s) \\\\\n\\hline \\multicolumn{4}{|l|}{Primary} \\\\\n\\hline mRS 0-1 Day 90 & Risk difference via linear regression, Cl & LOCF + hot deck & ITT \\\\\n\\hline \\multicolumn{4}{|l|}{Secondary} \\\\\n\\hline mRS ordinal Day 90 & Proportional odds model Descriptive, frequencies & LOCF + hot deck & ITT \\\\\n\\hline Global outcome measure (Global test) & Logistic regression with a 4-dimensional outcome using GEE & LOCF + hot deck for mRS, non-response for death * & ITT \\\\\n\\hline \\multicolumn{4}{|l|}{Exploratory} \\\\\n\\hline mRS 0-1 Day 90 & Logistic regression & LOCF + hot deck & ITT \\\\\n\\hline & Logistic regression with Day 30 and Day 90 outcome using GEE & Repeated Measures Model (No imputation) & ITT \\\\\n\\hline mRS 0 Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & LOCF + hot deck & ITT \\\\\n\\hline NIHSS 0, Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & No imputation & ITT \\\\\n\\hline NIHSS 0-1, Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & No imputation & ITT \\\\\n\\hline BI 100, Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & No imputation & ITT \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2\nSummary of Efficacy Analyses}\n\\begin{tabular}{|l|l|l|l|}\n\\hline Analysis & Statistical Method & Missing Data Method & Analysis Set(s) \\\\\n\\hline \\multicolumn{4}{|l|}{Primary} \\\\\n\\hline mRS 0-1 Day 90 & Risk difference via linear regression, Cl & LOCF + hot deck & ITT \\\\\n\\hline \\multicolumn{4}{|l|}{Secondary} \\\\\n\\hline mRS ordinal Day 90 & Proportional odds model Descriptive, frequencies & LOCF + hot deck & ITT \\\\\n\\hline Global outcome measure (Global test) & Logistic regression with a 4-dimensional outcome using GEE & LOCF + hot deck for mRS, non-response for death * & ITT \\\\\n\\hline \\multicolumn{4}{|l|}{Exploratory} \\\\\n\\hline mRS 0-1 Day 90 & Logistic regression & LOCF + hot deck & ITT \\\\\n\\hline & Logistic regression with Day 30 and Day 90 outcome using GEE & Repeated Measures Model (No imputation) & ITT \\\\\n\\hline mRS 0 Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & LOCF + hot deck & ITT \\\\\n\\hline NIHSS 0, Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & No imputation & ITT \\\\\n\\hline NIHSS 0-1, Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & No imputation & ITT \\\\\n\\hline BI 100, Day 90 & Descriptive, the risk difference via linear regression OR via logistic regression & No imputation & ITT \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.7607421875,"confidence_rate":0.9997974988848892},{"cnt":[[439,554],[742,554],[744,2284],[442,2285]],"region":{"top_left_x":439,"top_left_y":553,"width":306,"height":1732},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bae5ef76784f47ae91219385a342f142","type":"table_column","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[790,554],[1139,554],[1139,2284],[790,2284]],"region":{"top_left_x":790,"top_left_y":554,"width":349,"height":1731},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8648d567ca88475f94087bec9a382529","type":"table_column","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[1184,554],[1501,554],[1501,2284],[1184,2284]],"region":{"top_left_x":1184,"top_left_y":554,"width":317,"height":1731},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c95d7588808242378be199da5907c0d5","type":"table_column","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[1518,554],[1726,554],[1726,2284],[1518,2284]],"region":{"top_left_x":1517,"top_left_y":554,"width":209,"height":1731},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6edaf0f44864ff1bf410777f57324c9","type":"table_column","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,567],[1747,567],[1747,610],[433,610]],"region":{"top_left_x":433,"top_left_y":566,"width":1315,"height":45},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f4473e7a17b460989a770072591a042","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,619],[1747,619],[1747,662],[433,662]],"region":{"top_left_x":433,"top_left_y":618,"width":1315,"height":45},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ba346748b3d48bd80ff623b6903bc28","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,664],[1747,664],[1747,749],[433,749]],"region":{"top_left_x":433,"top_left_y":664,"width":1315,"height":85},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"608492aad4a947f2acd641cbe653f5ab","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,801],[1747,801],[1747,842],[433,842]],"region":{"top_left_x":433,"top_left_y":800,"width":1315,"height":43},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c65ea5271ac4a669067186e189746b8","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,849],[1747,849],[1747,937],[433,937]],"region":{"top_left_x":433,"top_left_y":848,"width":1315,"height":90},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bda32a6ffbb40eba30edf1b34c5d27d","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1087],[1747,1087],[1747,1206],[433,1206]],"region":{"top_left_x":433,"top_left_y":1086,"width":1315,"height":120},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3348f853735d4da5bc160312e499ef86","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1258],[1745,1258],[1745,1297],[433,1297]],"region":{"top_left_x":433,"top_left_y":1257,"width":1313,"height":40},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c67d626444ec41f6b4dde6324da14594","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1308],[1745,1305],[1745,1348],[433,1350]],"region":{"top_left_x":432,"top_left_y":1305,"width":1314,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a615639be1774e3ba10b93ddc4d9b8de","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1355],[1747,1355],[1747,1468],[433,1468]],"region":{"top_left_x":433,"top_left_y":1355,"width":1315,"height":113},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a518693ab43c42f7840fb3237050ebba","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1520],[1747,1520],[1747,1671],[433,1671]],"region":{"top_left_x":433,"top_left_y":1519,"width":1315,"height":153},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f4b3a978cf44ccf9bdd5842fc2e5467","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1723],[1745,1723],[1745,1873],[433,1873]],"region":{"top_left_x":433,"top_left_y":1723,"width":1313,"height":150},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0960dc8c69d4caab3fc470afece00f1","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,1925],[1745,1925],[1745,2074],[433,2074]],"region":{"top_left_x":433,"top_left_y":1924,"width":1313,"height":151},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fddae43cfa0540a0aab1d3995a1c3c64","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[433,2126],[1747,2126],[1747,2278],[433,2278]],"region":{"top_left_x":433,"top_left_y":2126,"width":1315,"height":152},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f88f7f1a1194e80b5e38807f6262f03","type":"table_row","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"","text_display":""},{"cnt":[[541,571],[656,571],[656,608],[541,608]],"region":{"top_left_x":541,"top_left_y":571,"width":116,"height":38},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72ba6840108a4cc78eac56bfff7ba615","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"Analysis","text_display":"Analysis","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[849,571],[1080,571],[1080,599],[849,599]],"region":{"top_left_x":848,"top_left_y":571,"width":233,"height":29},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9fee37b7a2f4732b77c8860fc6dbe4c","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"Statistical Method","text_display":"Statistical Method","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1197,571],[1475,571],[1475,608],[1197,608]],"region":{"top_left_x":1197,"top_left_y":571,"width":278,"height":38},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc63babbfbd24ecf8fde57d614a68a2c","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"Missing Data Method","text_display":"Missing Data Method","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1520,571],[1721,571],[1721,608],[1520,608]],"region":{"top_left_x":1520,"top_left_y":571,"width":202,"height":38},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1eed505eb1e14b4b989a8d431236c36b","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"Analysis Set(s)","text_display":"Analysis Set(s)","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[437,619],[1726,619],[1726,662],[437,662]],"region":{"top_left_x":437,"top_left_y":618,"width":1289,"height":45},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13cdf1219d4d4abbbc2862b0096ce703","type":"table_spanning_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["d92bd6df9ea348f38a812ea05c5459d1"],"text":"","text_display":"Primary","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":4},{"cnt":[[446,619],[556,619],[556,660],[446,660]],"region":{"top_left_x":445,"top_left_y":618,"width":112,"height":43},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d92bd6df9ea348f38a812ea05c5459d1","type":"simple_cell","conversion_output":false,"parent_id":"13cdf1219d4d4abbbc2862b0096ce703","text":"Primary","text_display":"Primary","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":4,"confidence":1,"confidence_rate":1},{"cnt":[[474,671],[695,671],[695,708],[474,708]],"region":{"top_left_x":474,"top_left_y":670,"width":222,"height":38},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67cb14f19dbe4be09db569758f7ecb4f","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"mRS 0-1 Day 90","text_display":"mRS 0-1 Day 90","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[797,671],[1124,671],[1124,742],[797,742]],"region":{"top_left_x":796,"top_left_y":670,"width":328,"height":73},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0af5d3eaf8149d9be430eac28ce3d0a","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["cd0030db7d0546b1b95af8e028b72e6c","d80fa4aee7e542b99772b73d43aa6b41"],"text":"Risk difference via linear regression, Cl","text_display":"Risk difference via linear regression, Cl","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.7607421875,"confidence_rate":0.9928294958405259},{"cnt":[[801,671],[1119,671],[1119,703],[801,703]],"region":{"top_left_x":801,"top_left_y":670,"width":319,"height":34},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd0030db7d0546b1b95af8e028b72e6c","type":"text","conversion_output":false,"parent_id":"d0af5d3eaf8149d9be430eac28ce3d0a","text":"Risk difference via linear","text_display":"Risk difference via linear","confidence":1,"confidence_rate":1},{"cnt":[[801,706],[985,706],[985,742],[801,742]],"region":{"top_left_x":801,"top_left_y":705,"width":185,"height":38},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d80fa4aee7e542b99772b73d43aa6b41","type":"text","conversion_output":false,"parent_id":"d0af5d3eaf8149d9be430eac28ce3d0a","text":"regression, Cl","text_display":" regression, Cl","confidence":0.7607421875,"confidence_rate":0.9857104078109529},{"cnt":[[1191,671],[1416,671],[1416,703],[1191,703]],"region":{"top_left_x":1190,"top_left_y":670,"width":227,"height":34},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"332266fcf7f14d3399014d4aa8d6519e","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"LOCF + hot deck","text_display":"LOCF + hot deck","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,660],[1676,660],[1676,706],[1620,706]],"region":{"top_left_x":1619,"top_left_y":660,"width":57,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d14bf58742b455aa4fdc3160e48b774","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[442,801],[1726,801],[1726,842],[442,842]],"region":{"top_left_x":441,"top_left_y":800,"width":1285,"height":43},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7537bea6c1ff48cca148b629b5e8ced8","type":"table_spanning_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["b800e7257d7c40d6bad42dea5fb757b2"],"text":"","text_display":"Secondary","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":4},{"cnt":[[444,805],[595,805],[595,842],[444,842]],"region":{"top_left_x":443,"top_left_y":805,"width":153,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b800e7257d7c40d6bad42dea5fb757b2","type":"simple_cell","conversion_output":false,"parent_id":"7537bea6c1ff48cca148b629b5e8ced8","text":"Secondary","text_display":"Secondary","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":4,"confidence":1,"confidence_rate":1},{"cnt":[[474,853],[738,853],[738,890],[474,890]],"region":{"top_left_x":474,"top_left_y":852,"width":265,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ab865368c12340caa8ddf5458f098d4b","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"mRS ordinal Day 90","text_display":"mRS ordinal Day 90","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999555900930661},{"cnt":[[797,853],[1119,853],[1119,933],[797,933]],"region":{"top_left_x":796,"top_left_y":852,"width":324,"height":81},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"107baf128eeb40eabafbfc6467ad0d02","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["23b327ce296542eb9e99601cc8f49dbc","b949e858b2e44a7dbbb9b036700d873c"],"text":"Proportional odds model Descriptive, frequencies","text_display":"Proportional odds model Descriptive, frequencies","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,853],[1119,853],[1119,890],[801,890]],"region":{"top_left_x":801,"top_left_y":852,"width":319,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23b327ce296542eb9e99601cc8f49dbc","type":"text","conversion_output":false,"parent_id":"107baf128eeb40eabafbfc6467ad0d02","text":"Proportional odds model","text_display":"Proportional odds model","confidence":1,"confidence_rate":1},{"cnt":[[801,896],[1115,896],[1115,933],[801,933]],"region":{"top_left_x":801,"top_left_y":896,"width":315,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b949e858b2e44a7dbbb9b036700d873c","type":"text","conversion_output":false,"parent_id":"107baf128eeb40eabafbfc6467ad0d02","text":"Descriptive, frequencies","text_display":" Descriptive, frequencies","confidence":1,"confidence_rate":1},{"cnt":[[1191,853],[1416,853],[1416,885],[1191,885]],"region":{"top_left_x":1190,"top_left_y":852,"width":227,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a371ab7c357c4577b0d4d45e6c9c3c8a","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"LOCF + hot deck","text_display":"LOCF + hot deck","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,851],[1676,851],[1676,887],[1620,887]],"region":{"top_left_x":1619,"top_left_y":850,"width":57,"height":38},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e88f224c09b40faa5051dc262303e59","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":4,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[442,1091],[730,1091],[730,1167],[442,1167]],"region":{"top_left_x":441,"top_left_y":1091,"width":289,"height":76},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98f35176a85348aeaf9ab817955a6dc4","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["ceba1be35a8f47ad926af4f6691e9974","1d5de7229850433a908cf8fc2237613e"],"text":"Global outcome measure (Global test)","text_display":"Global outcome measure (Global test)","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[474,1095],[682,1095],[682,1124],[474,1124]],"region":{"top_left_x":474,"top_left_y":1095,"width":209,"height":29},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ceba1be35a8f47ad926af4f6691e9974","type":"text","conversion_output":false,"parent_id":"98f35176a85348aeaf9ab817955a6dc4","text":"Global outcome","text_display":"Global outcome","confidence":1,"confidence_rate":1},{"cnt":[[446,1126],[730,1126],[730,1163],[446,1163]],"region":{"top_left_x":445,"top_left_y":1125,"width":285,"height":38},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d5de7229850433a908cf8fc2237613e","type":"text","conversion_output":false,"parent_id":"98f35176a85348aeaf9ab817955a6dc4","text":"measure (Global test)","text_display":" measure (Global test)","confidence":1,"confidence_rate":1},{"cnt":[[797,1091],[1132,1091],[1132,1201],[797,1201]],"region":{"top_left_x":796,"top_left_y":1091,"width":337,"height":111},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4524c34da0a34f1488495d54cc7b1965","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["2ce5197a264d409eb72dc15b129fba86","86c4da4626aa4cc9afad193e8617bfe0","99ddf46afc9d4b108f96b2a46a711e9b"],"text":"Logistic regression with a 4-dimensional outcome using GEE","text_display":"Logistic regression with a 4-dimensional outcome using GEE","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[799,1093],[1128,1093],[1128,1128],[799,1128]],"region":{"top_left_x":798,"top_left_y":1093,"width":331,"height":35},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ce5197a264d409eb72dc15b129fba86","type":"text","conversion_output":false,"parent_id":"4524c34da0a34f1488495d54cc7b1965","text":"Logistic regression with a","text_display":"Logistic regression with a","confidence":1,"confidence_rate":1},{"cnt":[[799,1128],[1104,1128],[1104,1158],[799,1158]],"region":{"top_left_x":798,"top_left_y":1127,"width":307,"height":32},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86c4da4626aa4cc9afad193e8617bfe0","type":"text","conversion_output":false,"parent_id":"4524c34da0a34f1488495d54cc7b1965","text":"4-dimensional outcome","text_display":" 4-dimensional outcome","confidence":1,"confidence_rate":1},{"cnt":[[801,1160],[942,1160],[942,1197],[801,1197]],"region":{"top_left_x":801,"top_left_y":1160,"width":141,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99ddf46afc9d4b108f96b2a46a711e9b","type":"text","conversion_output":false,"parent_id":"4524c34da0a34f1488495d54cc7b1965","text":"using GEE","text_display":" using GEE","confidence":1,"confidence_rate":1},{"cnt":[[1187,1091],[1496,1091],[1496,1197],[1187,1197]],"region":{"top_left_x":1186,"top_left_y":1091,"width":311,"height":107},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03fe6f7b3cca4e64bd6db5d18590ca5c","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["c2565f0f7181404481e8ed266135e871","d729f2f20ff1445b8bab60f2f807b80f","309ed117bc1748468ab864674c90f5b6"],"text":"LOCF + hot deck for mRS, non-response for death *","text_display":"LOCF + hot deck for mRS, non-response for death *","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.9912109375,"confidence_rate":0.9996416659940058},{"cnt":[[1191,1093],[1457,1093],[1457,1124],[1191,1124]],"region":{"top_left_x":1190,"top_left_y":1093,"width":268,"height":31},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2565f0f7181404481e8ed266135e871","type":"text","conversion_output":false,"parent_id":"03fe6f7b3cca4e64bd6db5d18590ca5c","text":"LOCF + hot deck for","text_display":"LOCF + hot deck for","confidence":1,"confidence_rate":1},{"cnt":[[1191,1126],[1496,1126],[1496,1163],[1191,1163]],"region":{"top_left_x":1190,"top_left_y":1125,"width":307,"height":38},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d729f2f20ff1445b8bab60f2f807b80f","type":"text","conversion_output":false,"parent_id":"03fe6f7b3cca4e64bd6db5d18590ca5c","text":"mRS, non-response for","text_display":" mRS, non-response for","confidence":0.9912109375,"confidence_rate":0.99966052247694},{"cnt":[[1191,1160],[1288,1160],[1288,1193],[1191,1193]],"region":{"top_left_x":1190,"top_left_y":1160,"width":99,"height":33},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"309ed117bc1748468ab864674c90f5b6","type":"text","conversion_output":false,"parent_id":"03fe6f7b3cca4e64bd6db5d18590ca5c","text":"death *","text_display":" death *","confidence":0.9912109375,"confidence_rate":0.9992646110208168},{"cnt":[[1620,1091],[1676,1091],[1676,1126],[1620,1126]],"region":{"top_left_x":1619,"top_left_y":1091,"width":57,"height":35},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea03f1b43252464ead7751b64767f734","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":5,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[442,1256],[1726,1256],[1726,1297],[442,1297]],"region":{"top_left_x":441,"top_left_y":1255,"width":1285,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76e81a23292f4409b70e8fea75aa2c77","type":"table_spanning_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["09c2d0170971458da1eb009db3245783"],"text":"","text_display":"Exploratory","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":4},{"cnt":[[446,1260],[611,1260],[611,1297],[446,1297]],"region":{"top_left_x":445,"top_left_y":1259,"width":166,"height":38},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09c2d0170971458da1eb009db3245783","type":"simple_cell","conversion_output":false,"parent_id":"76e81a23292f4409b70e8fea75aa2c77","text":"Exploratory","text_display":"Exploratory","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":4,"confidence":1,"confidence_rate":1},{"cnt":[[474,1312],[695,1312],[695,1344],[474,1344]],"region":{"top_left_x":474,"top_left_y":1311,"width":222,"height":34},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d83afea384024e4a9e2ceb83387242b6","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"mRS 0-1 Day 90","text_display":"mRS 0-1 Day 90","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1310],[1046,1310],[1046,1344],[801,1344]],"region":{"top_left_x":801,"top_left_y":1309,"width":245,"height":36},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd803cc10e384ca7bd8ba1eeea91eebc","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"Logistic regression","text_display":"Logistic regression","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1191,1310],[1416,1310],[1416,1340],[1191,1340]],"region":{"top_left_x":1190,"top_left_y":1309,"width":227,"height":32},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d03323743e24685ab1d0e41913f9655","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"LOCF + hot deck","text_display":"LOCF + hot deck","cell_row":7,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,1305],[1676,1305],[1676,1342],[1620,1342]],"region":{"top_left_x":1619,"top_left_y":1305,"width":57,"height":38},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68101b004af64ab1b96bd1d6c1702e2f","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":7,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[797,1357],[1106,1357],[1106,1466],[797,1466]],"region":{"top_left_x":796,"top_left_y":1357,"width":311,"height":109},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ebe5ce58f6d4524ad065aca252c9c71","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["9d5c85c3a5424bedbd1703469ac33e0f","66317c5b112c4c2084ecab5347af8a5a","aa27a989cba24a2a81befeb8f6f73b84"],"text":"Logistic regression with Day 30 and Day 90 outcome using GEE","text_display":"Logistic regression with Day 30 and Day 90 outcome using GEE","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1360],[1106,1360],[1106,1394],[801,1394]],"region":{"top_left_x":801,"top_left_y":1359,"width":306,"height":36},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d5c85c3a5424bedbd1703469ac33e0f","type":"text","conversion_output":false,"parent_id":"3ebe5ce58f6d4524ad065aca252c9c71","text":"Logistic regression with","text_display":"Logistic regression with","confidence":1,"confidence_rate":1},{"cnt":[[801,1394],[1052,1394],[1052,1429],[801,1429]],"region":{"top_left_x":801,"top_left_y":1394,"width":252,"height":35},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"66317c5b112c4c2084ecab5347af8a5a","type":"text","conversion_output":false,"parent_id":"3ebe5ce58f6d4524ad065aca252c9c71","text":"Day 30 and Day 90","text_display":" Day 30 and Day 90","confidence":1,"confidence_rate":1},{"cnt":[[801,1429],[1061,1429],[1061,1461],[801,1461]],"region":{"top_left_x":801,"top_left_y":1428,"width":260,"height":34},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa27a989cba24a2a81befeb8f6f73b84","type":"text","conversion_output":false,"parent_id":"3ebe5ce58f6d4524ad065aca252c9c71","text":"outcome using GEE","text_display":" outcome using GEE","confidence":1,"confidence_rate":1},{"cnt":[[1189,1360],[1483,1360],[1483,1431],[1189,1431]],"region":{"top_left_x":1188,"top_left_y":1359,"width":296,"height":73},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5259e21167254d1fbb2ee9e6beca165e","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["5141c90c81e143f69b8fca8e12323d4f","2ff5cee8aa284d9f98c0a7d952668680"],"text":"Repeated Measures Model (No imputation)","text_display":"Repeated Measures Model (No imputation)","cell_row":8,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1191,1360],[1457,1360],[1457,1392],[1191,1392]],"region":{"top_left_x":1190,"top_left_y":1359,"width":268,"height":34},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5141c90c81e143f69b8fca8e12323d4f","type":"text","conversion_output":false,"parent_id":"5259e21167254d1fbb2ee9e6beca165e","text":"Repeated Measures","text_display":"Repeated Measures","confidence":1,"confidence_rate":1},{"cnt":[[1191,1394],[1479,1394],[1479,1427],[1191,1427]],"region":{"top_left_x":1190,"top_left_y":1394,"width":289,"height":33},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ff5cee8aa284d9f98c0a7d952668680","type":"text","conversion_output":false,"parent_id":"5259e21167254d1fbb2ee9e6beca165e","text":"Model (No imputation)","text_display":" Model (No imputation)","confidence":1,"confidence_rate":1},{"cnt":[[1620,1357],[1676,1357],[1676,1392],[1620,1392]],"region":{"top_left_x":1619,"top_left_y":1357,"width":57,"height":36},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4d051723e844ee08b1587b004717ca0","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":8,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[472,1527],[669,1524],[669,1561],[472,1563]],"region":{"top_left_x":471,"top_left_y":1524,"width":199,"height":40},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aee7f3de1537433ea07b8d90320077a1","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"mRS 0 Day 90","text_display":"mRS 0 Day 90","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[797,1524],[1137,1524],[1137,1667],[797,1667]],"region":{"top_left_x":796,"top_left_y":1524,"width":341,"height":144},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85334165d1304b68b880684131742c6e","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["2dc323846d014990a0714445e24a56e0","2cb31eec84ed48e39903d4fed9511fa7","94cfbc60f7af4b7da32c17dc03e7ccbb","db16a86d88c049c7bd33a88f1f40d275"],"text":"Descriptive, the risk difference via linear regression OR via logistic regression","text_display":"Descriptive, the risk difference via linear regression OR via logistic regression","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1528],[1059,1528],[1059,1561],[801,1561]],"region":{"top_left_x":801,"top_left_y":1528,"width":258,"height":33},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2dc323846d014990a0714445e24a56e0","type":"text","conversion_output":false,"parent_id":"85334165d1304b68b880684131742c6e","text":"Descriptive, the risk","text_display":"Descriptive, the risk","confidence":1,"confidence_rate":1},{"cnt":[[801,1563],[1059,1563],[1059,1591],[801,1591]],"region":{"top_left_x":801,"top_left_y":1563,"width":258,"height":29},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2cb31eec84ed48e39903d4fed9511fa7","type":"text","conversion_output":false,"parent_id":"85334165d1304b68b880684131742c6e","text":"difference via linear","text_display":" difference via linear","confidence":1,"confidence_rate":1},{"cnt":[[801,1598],[1132,1598],[1132,1630],[801,1630]],"region":{"top_left_x":801,"top_left_y":1597,"width":332,"height":34},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94cfbc60f7af4b7da32c17dc03e7ccbb","type":"text","conversion_output":false,"parent_id":"85334165d1304b68b880684131742c6e","text":"regression OR via logistic","text_display":" regression OR via logistic","confidence":1,"confidence_rate":1},{"cnt":[[801,1632],[938,1632],[938,1665],[801,1665]],"region":{"top_left_x":801,"top_left_y":1632,"width":137,"height":33},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db16a86d88c049c7bd33a88f1f40d275","type":"text","conversion_output":false,"parent_id":"85334165d1304b68b880684131742c6e","text":"regression","text_display":" regression","confidence":1,"confidence_rate":1},{"cnt":[[1191,1526],[1416,1526],[1416,1561],[1191,1561]],"region":{"top_left_x":1190,"top_left_y":1526,"width":227,"height":35},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3ae166aa46174deab98893af3fc93b70","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"LOCF + hot deck","text_display":"LOCF + hot deck","cell_row":9,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,1528],[1676,1528],[1676,1559],[1620,1559]],"region":{"top_left_x":1619,"top_left_y":1528,"width":57,"height":31},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cd9dc1568a44f398bc628005f642a6a","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":9,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[474,1728],[699,1728],[699,1765],[474,1765]],"region":{"top_left_x":474,"top_left_y":1727,"width":226,"height":38},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd54a3146dde429382780b8b624ae733","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"NIHSS 0, Day 90","text_display":"NIHSS 0, Day 90","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[797,1728],[1137,1728],[1137,1868],[797,1868]],"region":{"top_left_x":796,"top_left_y":1727,"width":341,"height":142},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d21d7b0fca1497b82a77d15b1ef69ce","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["1bb04da3af584cfda148545c112cfe6c","c64b037897964c9c8e8535a8d53001a3","af8767eb4dc54c9d9ea13d2c007d5cde","4c709d3c0c914041876b8017d101c9b5"],"text":"Descriptive, the risk difference via linear regression OR via logistic regression","text_display":"Descriptive, the risk difference via linear regression OR via logistic regression","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1728],[1059,1728],[1059,1765],[801,1765]],"region":{"top_left_x":801,"top_left_y":1727,"width":258,"height":38},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bb04da3af584cfda148545c112cfe6c","type":"text","conversion_output":false,"parent_id":"5d21d7b0fca1497b82a77d15b1ef69ce","text":"Descriptive, the risk","text_display":"Descriptive, the risk","confidence":1,"confidence_rate":1},{"cnt":[[801,1762],[1059,1762],[1059,1795],[801,1795]],"region":{"top_left_x":801,"top_left_y":1762,"width":258,"height":33},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c64b037897964c9c8e8535a8d53001a3","type":"text","conversion_output":false,"parent_id":"5d21d7b0fca1497b82a77d15b1ef69ce","text":"difference via linear","text_display":" difference via linear","confidence":1,"confidence_rate":1},{"cnt":[[801,1797],[1132,1797],[1132,1834],[801,1834]],"region":{"top_left_x":801,"top_left_y":1796,"width":332,"height":38},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af8767eb4dc54c9d9ea13d2c007d5cde","type":"text","conversion_output":false,"parent_id":"5d21d7b0fca1497b82a77d15b1ef69ce","text":"regression OR via logistic","text_display":" regression OR via logistic","confidence":1,"confidence_rate":1},{"cnt":[[801,1836],[938,1836],[938,1868],[801,1868]],"region":{"top_left_x":801,"top_left_y":1835,"width":137,"height":34},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c709d3c0c914041876b8017d101c9b5","type":"text","conversion_output":false,"parent_id":"5d21d7b0fca1497b82a77d15b1ef69ce","text":"regression","text_display":" regression","confidence":1,"confidence_rate":1},{"cnt":[[1191,1728],[1375,1728],[1375,1765],[1191,1765]],"region":{"top_left_x":1190,"top_left_y":1727,"width":185,"height":38},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d25326b5faf24a3c887d2c7cd830a2de","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"No imputation","text_display":"No imputation","cell_row":10,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,1726],[1676,1726],[1676,1762],[1620,1762]],"region":{"top_left_x":1619,"top_left_y":1725,"width":57,"height":38},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa3225d8d926476faa0b42f784c19cbf","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":10,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[474,1931],[725,1931],[725,1968],[474,1968]],"region":{"top_left_x":474,"top_left_y":1931,"width":252,"height":38},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2a362f7f66b4379a5e9591ff61b828b","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"NIHSS 0-1, Day 90","text_display":"NIHSS 0-1, Day 90","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[797,1929],[1137,1929],[1137,2072],[797,2072]],"region":{"top_left_x":796,"top_left_y":1929,"width":341,"height":144},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92c9f97205cf43a5bc75a199f4030d93","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["7d35128241064a5295348a0dc7444308","640098b2ffa14e8abc3f5bd4e22e71ba","9b19e3c273e640e29c176fa757d67709","ca2d55ac09684d3f847a82c41445cf47"],"text":"Descriptive, the risk difference via linear regression OR via logistic regression","text_display":"Descriptive, the risk difference via linear regression OR via logistic regression","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,1931],[1059,1931],[1059,1966],[801,1966]],"region":{"top_left_x":801,"top_left_y":1931,"width":258,"height":35},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d35128241064a5295348a0dc7444308","type":"text","conversion_output":false,"parent_id":"92c9f97205cf43a5bc75a199f4030d93","text":"Descriptive, the risk","text_display":"Descriptive, the risk","confidence":1,"confidence_rate":1},{"cnt":[[801,1966],[1059,1966],[1059,1998],[801,1998]],"region":{"top_left_x":801,"top_left_y":1965,"width":258,"height":34},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"640098b2ffa14e8abc3f5bd4e22e71ba","type":"text","conversion_output":false,"parent_id":"92c9f97205cf43a5bc75a199f4030d93","text":"difference via linear","text_display":" difference via linear","confidence":1,"confidence_rate":1},{"cnt":[[801,2001],[1132,2001],[1132,2037],[801,2037]],"region":{"top_left_x":801,"top_left_y":2000,"width":332,"height":38},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b19e3c273e640e29c176fa757d67709","type":"text","conversion_output":false,"parent_id":"92c9f97205cf43a5bc75a199f4030d93","text":"regression OR via logistic","text_display":" regression OR via logistic","confidence":1,"confidence_rate":1},{"cnt":[[801,2035],[938,2035],[938,2070],[801,2070]],"region":{"top_left_x":801,"top_left_y":2035,"width":137,"height":35},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca2d55ac09684d3f847a82c41445cf47","type":"text","conversion_output":false,"parent_id":"92c9f97205cf43a5bc75a199f4030d93","text":"regression","text_display":" regression","confidence":1,"confidence_rate":1},{"cnt":[[1191,1931],[1375,1931],[1375,1968],[1191,1968]],"region":{"top_left_x":1190,"top_left_y":1931,"width":185,"height":38},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1c348e9ad814d6d8a814ee907891782","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"No imputation","text_display":"No imputation","cell_row":11,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,1931],[1676,1931],[1676,1968],[1620,1968]],"region":{"top_left_x":1619,"top_left_y":1931,"width":57,"height":38},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7868009326564a42bd55ed5443857b52","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":11,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[474,2135],[669,2135],[669,2169],[474,2169]],"region":{"top_left_x":474,"top_left_y":2134,"width":196,"height":36},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"465f59a675264faab32467788bcd2d11","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"BI 100, Day 90","text_display":"BI 100, Day 90","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99462890625,"confidence_rate":0.9997008464257681},{"cnt":[[797,2133],[1137,2133],[1137,2276],[797,2276]],"region":{"top_left_x":796,"top_left_y":2132,"width":341,"height":144},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe1cda865f6e454694eb6e34235d3947","type":"complex_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","children_ids":["ed960f43cb7542f0bb6ff3c9e8ed3834","9f8dd834b330442bb8876971314206bc","4e2a067085124ab28bfb25aeb818de90","5583c9f946d5410c9e94b91bc3e47cb7"],"text":"Descriptive, the risk difference via linear regression OR via logistic regression","text_display":"Descriptive, the risk difference via linear regression OR via logistic regression","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[801,2135],[1059,2135],[1059,2167],[801,2167]],"region":{"top_left_x":801,"top_left_y":2134,"width":258,"height":34},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed960f43cb7542f0bb6ff3c9e8ed3834","type":"text","conversion_output":false,"parent_id":"fe1cda865f6e454694eb6e34235d3947","text":"Descriptive, the risk","text_display":"Descriptive, the risk","confidence":1,"confidence_rate":1},{"cnt":[[801,2169],[1059,2169],[1059,2202],[801,2202]],"region":{"top_left_x":801,"top_left_y":2169,"width":258,"height":33},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f8dd834b330442bb8876971314206bc","type":"text","conversion_output":false,"parent_id":"fe1cda865f6e454694eb6e34235d3947","text":"difference via linear","text_display":" difference via linear","confidence":1,"confidence_rate":1},{"cnt":[[801,2204],[1132,2204],[1132,2239],[801,2239]],"region":{"top_left_x":801,"top_left_y":2204,"width":332,"height":35},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e2a067085124ab28bfb25aeb818de90","type":"text","conversion_output":false,"parent_id":"fe1cda865f6e454694eb6e34235d3947","text":"regression OR via logistic","text_display":" regression OR via logistic","confidence":1,"confidence_rate":1},{"cnt":[[801,2239],[938,2239],[938,2271],[801,2271]],"region":{"top_left_x":801,"top_left_y":2238,"width":137,"height":34},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5583c9f946d5410c9e94b91bc3e47cb7","type":"text","conversion_output":false,"parent_id":"fe1cda865f6e454694eb6e34235d3947","text":"regression","text_display":" regression","confidence":1,"confidence_rate":1},{"cnt":[[1191,2133],[1373,2133],[1373,2169],[1191,2169]],"region":{"top_left_x":1190,"top_left_y":2132,"width":183,"height":38},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a10f92de3c0d4af4a014f3eb9d542e23","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"No imputation","text_display":"No imputation","cell_row":12,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1620,2135],[1676,2135],[1676,2178],[1620,2178]],"region":{"top_left_x":1619,"top_left_y":2134,"width":57,"height":45},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50153c1d8b7d461ba3855f36e82a8cf0","type":"simple_cell","conversion_output":false,"parent_id":"a0d71042eb6e4ddf83599b9aa4d0c4d7","text":"ITT","text_display":"ITT","cell_row":12,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bf921c893f54dac9a9cef6387159d2a","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1184,2368],[1184,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":751,"height":33},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"483ccd6f48a54a038b59474fc6ec269e","type":"text","conversion_output":true,"text":"21/ML29093 5/17/2017","text_display":"\n21/ML29093 5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"241295c2ec5c4f9c9b242b94eb4c1e70","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9917230340734022,"confidence_rate":0.9998721403254606},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"455355f356504cb7ab3b13baa8aed93c","type":"page_info","conversion_output":false,"text":"782/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-23","page":23,"lines":[{"cnt":[[473,494],[677,494],[677,531],[473,531]],"region":{"top_left_x":472,"top_left_y":494,"width":205,"height":37},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"172178d7a1614ee89891ef49e4db9050","type":"page_info","conversion_output":false,"text":"GOS 1, Day 90","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[797,492],[1140,492],[1140,642],[797,642]],"region":{"top_left_x":797,"top_left_y":492,"width":343,"height":150},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"58a18b66f37d4779a392d505bd60cce8","type":"column","conversion_output":false,"children_ids":["1f4ca4c5996b4820a25dfcf428658856","7dab25d5ee5640d8805ec8a2f9d2b131","37810b888e0a42b5ab36949d2307d950","4aaa6c153f10454eae4c840f30806e40"],"text":"","text_display":""},{"cnt":[[799,494],[1059,494],[1059,531],[799,531]],"region":{"top_left_x":799,"top_left_y":494,"width":261,"height":37},"line":3,"column":1,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1f4ca4c5996b4820a25dfcf428658856","type":"text","conversion_output":true,"parent_id":"58a18b66f37d4779a392d505bd60cce8","text":"Descriptive, the risk","text_display":"\n\nDescriptive, the risk","confidence":1,"confidence_rate":1},{"cnt":[[799,529],[1059,529],[1059,561],[799,561]],"region":{"top_left_x":799,"top_left_y":528,"width":261,"height":33},"line":4,"column":1,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7dab25d5ee5640d8805ec8a2f9d2b131","type":"text","conversion_output":true,"parent_id":"58a18b66f37d4779a392d505bd60cce8","text":"difference via linear","text_display":" difference via linear","confidence":1,"confidence_rate":1},{"cnt":[[799,563],[1137,563],[1137,604],[799,604]],"region":{"top_left_x":799,"top_left_y":562,"width":338,"height":42},"line":5,"column":1,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"37810b888e0a42b5ab36949d2307d950","type":"text","conversion_output":true,"parent_id":"58a18b66f37d4779a392d505bd60cce8","text":"regression OR via logistic","text_display":" regression OR via logistic","confidence":1,"confidence_rate":1},{"cnt":[[799,602],[939,602],[939,638],[799,638]],"region":{"top_left_x":799,"top_left_y":601,"width":140,"height":38},"line":6,"column":1,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4aaa6c153f10454eae4c840f30806e40","type":"text","conversion_output":true,"parent_id":"58a18b66f37d4779a392d505bd60cce8","text":"regression","text_display":" regression","confidence":1,"confidence_rate":1},{"cnt":[[1190,498],[1377,498],[1377,531],[1190,531]],"region":{"top_left_x":1190,"top_left_y":498,"width":188,"height":33},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"189abf7a787444c480531fabc7eec3d7","type":"text","conversion_output":true,"text":"No imputation","text_display":"\n\nNo imputation","confidence":1,"confidence_rate":1},{"cnt":[[1620,494],[1671,494],[1671,529],[1620,529]],"region":{"top_left_x":1619,"top_left_y":494,"width":53,"height":35},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"80a31b6138bb4c618ac1c6be3618b7d6","type":"text","conversion_output":true,"text":"ITT","text_display":"\nITT","confidence":1,"confidence_rate":1},{"cnt":[[443,683],[1729,683],[1729,728],[443,728]],"region":{"top_left_x":442,"top_left_y":683,"width":1288,"height":46},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8ae8758c80084cd495129d36824ca7bd","type":"text","conversion_output":true,"text":"* A full analysis set approach will be used, so that patients with missingness of some but not all Day","text_display":"\n* A full analysis set approach will be used, so that patients with missingness of some but not all Day","confidence":0.92626953125,"confidence_rate":0.9992844615756482},{"cnt":[[477,726],[1635,726],[1635,763],[477,763]],"region":{"top_left_x":476,"top_left_y":726,"width":1159,"height":37},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7c95eeaee5fc45b6a9860c481c93d57b","type":"text","conversion_output":true,"text":"90 endpoint components will be included the model and contr bute to the estimation of the","text_display":" 90 endpoint components will be included the model and contr bute to the estimation of the","confidence":1,"confidence_rate":1},{"cnt":[[477,758],[1721,758],[1721,797],[477,797]],"region":{"top_left_x":476,"top_left_y":758,"width":1245,"height":40},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f264f69c8228438681a57803e7666698","type":"text","conversion_output":true,"text":"common OR despite missing values on some of the end point components. Death before day 90","text_display":" common OR despite missing values on some of the end point components. Death before day 90","confidence":1,"confidence_rate":1},{"cnt":[[477,795],[1437,795],[1437,831],[477,831]],"region":{"top_left_x":476,"top_left_y":794,"width":962,"height":38},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0dcd2c9f6d4e4d38900294596836c7f0","type":"text","conversion_output":true,"text":"is considerd as having not achieved the four binary end point components.","text_display":" is considerd as having not achieved the four binary end point components.","confidence":1,"confidence_rate":1},{"cnt":[[327,920],[1717,920],[1717,973],[327,973]],"region":{"top_left_x":326,"top_left_y":919,"width":1391,"height":55},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67530c044b7446e094eae829425ddfa0","type":"section_header","conversion_output":false,"children_ids":["4ed4c22be86741e4a8ec56c1ae35226b"],"text":"","text_display":""},{"cnt":[[331,924],[1712,924],[1712,969],[331,969]],"region":{"top_left_x":330,"top_left_y":923,"width":1383,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ed4c22be86741e4a8ec56c1ae35226b","type":"text","conversion_output":true,"parent_id":"67530c044b7446e094eae829425ddfa0","text":"4.5 COGNITIVE, BEHAVIORAL AND PATIENT REPORTED OUTCOME ANALYSES","text_display":"\n\n\\subsection*{4.5 COGNITIVE, BEHAVIORAL AND PATIENT REPORTED OUTCOME ANALYSES}","confidence":1,"confidence_rate":1},{"cnt":[[430,993],[1583,993],[1583,1038],[430,1038]],"region":{"top_left_x":429,"top_left_y":992,"width":1155,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d91c30d5dab447328b6476ef6e526aee","type":"text","conversion_output":true,"text":"All the cognitive, behavioral and patient reported outcomes are considered","text_display":"\n\nAll the cognitive, behavioral and patient reported outcomes are considered","confidence":1,"confidence_rate":1},{"cnt":[[432,1044],[621,1044],[621,1089],[432,1089]],"region":{"top_left_x":431,"top_left_y":1044,"width":190,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35c6a8a04c674ccfb16aebf83412ac28","type":"text","conversion_output":true,"text":"exploratory.","text_display":" exploratory.","confidence":1,"confidence_rate":1},{"cnt":[[301,1130],[836,1130],[836,1182],[301,1182]],"region":{"top_left_x":300,"top_left_y":1130,"width":536,"height":52},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43ba978a06004e6da7dfeb9433255e70","type":"section_header","conversion_output":false,"children_ids":["b06d1f818bd74b5daaa338e4d6c2fb29"],"text":"","text_display":""},{"cnt":[[305,1134],[831,1134],[831,1179],[305,1179]],"region":{"top_left_x":305,"top_left_y":1134,"width":527,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b06d1f818bd74b5daaa338e4d6c2fb29","type":"text","conversion_output":true,"parent_id":"43ba978a06004e6da7dfeb9433255e70","text":"4.5.1 Cognitive Assessments","text_display":"\n\n\\subsection*{4.5.1 Cognitive Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[430,1199],[1671,1199],[1671,1248],[430,1248]],"region":{"top_left_x":429,"top_left_y":1198,"width":1243,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"473da2f20f7243819344af66afa57bd7","type":"text","conversion_output":true,"text":"A series of tests will be conducted at Day 90 to evaluate cognitive abilities of the","text_display":"\n\nA series of tests will be conducted at Day 90 to evaluate cognitive abilities of the","confidence":1,"confidence_rate":1},{"cnt":[[434,1255],[1588,1255],[1588,1300],[434,1300]],"region":{"top_left_x":433,"top_left_y":1254,"width":1155,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a41afb28cd444839d71790fd6f7f0b9","type":"text","conversion_output":true,"text":"patients. The tests and their outcomes are presented in the following table:","text_display":" patients. The tests and their outcomes are presented in the following table:","confidence":0.99658203125,"confidence_rate":0.9999577314692709},{"cnt":[[902,1345],[1278,1345],[1278,1442],[902,1442]],"region":{"top_left_x":902,"top_left_y":1344,"width":377,"height":98},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7451d2d5c86542c7a02e48c2a3aba248","type":"figure_label","conversion_output":false,"children_ids":["ce2c429f7064467e854834ff88f94cc1","27072c268a914cabaee058b5c506a87b"],"text":"","text_display":""},{"cnt":[[1023,1349],[1154,1349],[1154,1386],[1023,1386]],"region":{"top_left_x":1022,"top_left_y":1349,"width":132,"height":37},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce2c429f7064467e854834ff88f94cc1","type":"text","conversion_output":false,"parent_id":"7451d2d5c86542c7a02e48c2a3aba248","text":"Table 3","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[907,1396],[1274,1396],[1274,1437],[907,1437]],"region":{"top_left_x":906,"top_left_y":1396,"width":369,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27072c268a914cabaee058b5c506a87b","type":"text","conversion_output":false,"parent_id":"7451d2d5c86542c7a02e48c2a3aba248","text":"Cognitive Assessments","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[432,1454],[1745,1454],[1745,2004],[432,2004]],"region":{"top_left_x":431,"top_left_y":1454,"width":1314,"height":551},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"89719f19a0fb47fd8a17077023c137b3","type":"table","conversion_output":true,"children_ids":["828daf5fde214a65aa73264c24899321","f2791ac7a69343868c480b054aff42ae","8d3e280d10394f45b080c2add570dcbc","a920b4d69efd4b71ad46e81c13112d00","0f9bede972de4f6181e6c8bc89cdbff2","45d3af5e66544cc0ae637da8cf4e72f5","a752b5af2d7b40daacf9b0808c1cafa5","9bdb80168ae44b37b97c09aa6da7a42c","89fb798ef68c4116a89a33e2e00d4c7d","5a0a90a8ae5d4ac899dd4732c51509bc","2c436c73690e47f5ab669e5844741896","a3d39d637fdc409494c57eb89bfe52d4","ae0059af64ea4c9582f6647949d7e34b","a00aa0be12fd4c7089ceacf24b50c2cf","dbddc332b8b840f08f69db74c680aae0","185256db72794b4881c2c91d7a90b919","50fa396697d347dcbe83ee5d471fd5ee","21feaed68e79483c84fa55538087d823","3dbc489ac77d48ed8201bde95efbcb6e","203078fcd55849518e32a81b68512eca","de789950ce3e49cbbcd43e6d82473daf","4b0c320953bc42328d897305975a0c6e","514200c3df5a462e82914d54168c0540","f57f57bd43c74041b6c3af076688a404","61ccb6d6dfc04e2dbbb15dd474346fd9","4abf8af577e9485aa7630db1c3a7dc19"],"selected_labels":["7451d2d5c86542c7a02e48c2a3aba248"],"text":"\\begin{tabular}{|l|l|}\n\\hline Test & Outcome \\\\\n\\hline Controlled Oral Word Association test & Number of words listed \\\\\n\\hline Hopkins Verbal Learning test & Number of words recalled in 3 trials, Retention, and Recognition Discrimination Index \\\\\n\\hline Digit symbol coding from the Wechsler Adult Intelligence Scale & Number of correctly coded digits \\\\\n\\hline Forward and Backward Digit Span test & Maximum number of digits repeated, forward and backward scores \\\\\n\\hline Benton Judgment of Line Orientation, form V & Total score \\\\\n\\hline Animal Naming test & Number of unique animals named \\\\\n\\hline 15 -item Boston Naming test & Total number of items answered correctly either spontaneously or after a stimulus cue \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3\nCognitive Assessments}\n\\begin{tabular}{|l|l|}\n\\hline Test & Outcome \\\\\n\\hline Controlled Oral Word Association test & Number of words listed \\\\\n\\hline Hopkins Verbal Learning test & Number of words recalled in 3 trials, Retention, and Recognition Discrimination Index \\\\\n\\hline Digit symbol coding from the Wechsler Adult Intelligence Scale & Number of correctly coded digits \\\\\n\\hline Forward and Backward Digit Span test & Maximum number of digits repeated, forward and backward scores \\\\\n\\hline Benton Judgment of Line Orientation, form V & Total score \\\\\n\\hline Animal Naming test & Number of unique animals named \\\\\n\\hline 15 -item Boston Naming test & Total number of items answered correctly either spontaneously or after a stimulus cue \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.85107421875,"confidence_rate":0.9996624899584646},{"cnt":[[441,1454],[1027,1454],[1027,2006],[441,2006]],"region":{"top_left_x":441,"top_left_y":1454,"width":587,"height":552},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"828daf5fde214a65aa73264c24899321","type":"table_column","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[1086,1454],[1734,1454],[1734,2006],[1086,2006]],"region":{"top_left_x":1085,"top_left_y":1454,"width":649,"height":552},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f2791ac7a69343868c480b054aff42ae","type":"table_column","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1469],[1748,1469],[1748,1504],[431,1504]],"region":{"top_left_x":431,"top_left_y":1469,"width":1317,"height":35},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8d3e280d10394f45b080c2add570dcbc","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1519],[1749,1519],[1749,1559],[431,1559]],"region":{"top_left_x":431,"top_left_y":1519,"width":1319,"height":40},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a920b4d69efd4b71ad46e81c13112d00","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1567],[1746,1567],[1746,1645],[431,1645]],"region":{"top_left_x":431,"top_left_y":1567,"width":1315,"height":78},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0f9bede972de4f6181e6c8bc89cdbff2","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1652],[1746,1652],[1746,1731],[431,1731]],"region":{"top_left_x":431,"top_left_y":1651,"width":1315,"height":80},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"45d3af5e66544cc0ae637da8cf4e72f5","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1736],[1746,1736],[1746,1810],[431,1810]],"region":{"top_left_x":431,"top_left_y":1735,"width":1315,"height":75},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a752b5af2d7b40daacf9b0808c1cafa5","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1822],[1746,1820],[1746,1862],[431,1864]],"region":{"top_left_x":430,"top_left_y":1820,"width":1316,"height":44},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9bdb80168ae44b37b97c09aa6da7a42c","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1870],[1746,1870],[1746,1913],[431,1913]],"region":{"top_left_x":431,"top_left_y":1869,"width":1315,"height":44},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"89fb798ef68c4116a89a33e2e00d4c7d","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[431,1918],[1746,1918],[1746,1997],[431,1997]],"region":{"top_left_x":431,"top_left_y":1918,"width":1315,"height":80},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5a0a90a8ae5d4ac899dd4732c51509bc","type":"table_row","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"","text_display":""},{"cnt":[[730,1471],[797,1471],[797,1500],[730,1500]],"region":{"top_left_x":730,"top_left_y":1471,"width":68,"height":30},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c436c73690e47f5ab669e5844741896","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Test","text_display":"Test","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1352,1471],[1478,1471],[1478,1500],[1352,1500]],"region":{"top_left_x":1352,"top_left_y":1471,"width":126,"height":30},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3d39d637fdc409494c57eb89bfe52d4","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Outcome","text_display":"Outcome","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1523],[935,1523],[935,1555],[443,1555]],"region":{"top_left_x":443,"top_left_y":1522,"width":492,"height":34},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae0059af64ea4c9582f6647949d7e34b","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Controlled Oral Word Association test","text_display":"Controlled Oral Word Association test","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1523],[1395,1523],[1395,1555],[1094,1555]],"region":{"top_left_x":1094,"top_left_y":1522,"width":302,"height":34},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a00aa0be12fd4c7089ceacf24b50c2cf","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Number of words listed","text_display":"Number of words listed","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[441,1571],[823,1571],[823,1607],[441,1607]],"region":{"top_left_x":441,"top_left_y":1570,"width":382,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbddc332b8b840f08f69db74c680aae0","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Hopkins Verbal Learning test","text_display":"Hopkins Verbal Learning test","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1093,1569],[1705,1569],[1705,1645],[1093,1645]],"region":{"top_left_x":1092,"top_left_y":1569,"width":613,"height":76},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"185256db72794b4881c2c91d7a90b919","type":"complex_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","children_ids":["9efb1cebbe6c4548bea8c95830f51213","be1da9122a3b4c1dbb75f586fb273865"],"text":"Number of words recalled in 3 trials, Retention, and Recognition Discrimination Index","text_display":"Number of words recalled in 3 trials, Retention, and Recognition Discrimination Index","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1573],[1701,1573],[1701,1607],[1094,1607]],"region":{"top_left_x":1094,"top_left_y":1572,"width":608,"height":35},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9efb1cebbe6c4548bea8c95830f51213","type":"text","conversion_output":false,"parent_id":"185256db72794b4881c2c91d7a90b919","text":"Number of words recalled in 3 trials, Retention,","text_display":"Number of words recalled in 3 trials, Retention,","confidence":1,"confidence_rate":1},{"cnt":[[1094,1607],[1579,1607],[1579,1641],[1094,1641]],"region":{"top_left_x":1094,"top_left_y":1606,"width":486,"height":36},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be1da9122a3b4c1dbb75f586fb273865","type":"text","conversion_output":false,"parent_id":"185256db72794b4881c2c91d7a90b919","text":"and Recognition Discrimination Index","text_display":" and Recognition Discrimination Index","confidence":1,"confidence_rate":1},{"cnt":[[441,1653],[1021,1653],[1021,1731],[441,1731]],"region":{"top_left_x":441,"top_left_y":1653,"width":580,"height":78},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50fa396697d347dcbe83ee5d471fd5ee","type":"complex_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","children_ids":["50264952afe641498caf4883f014dae5","751378766b8b44488dba7cf25f5a693c"],"text":"Digit symbol coding from the Wechsler Adult Intelligence Scale","text_display":"Digit symbol coding from the Wechsler Adult Intelligence Scale","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999949125077527},{"cnt":[[445,1657],[1017,1657],[1017,1691],[445,1691]],"region":{"top_left_x":444,"top_left_y":1656,"width":574,"height":36},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50264952afe641498caf4883f014dae5","type":"text","conversion_output":false,"parent_id":"50fa396697d347dcbe83ee5d471fd5ee","text":"Digit symbol coding from the Wechsler Adult","text_display":"Digit symbol coding from the Wechsler Adult","confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[445,1691],[675,1691],[675,1726],[445,1726]],"region":{"top_left_x":444,"top_left_y":1691,"width":232,"height":35},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"751378766b8b44488dba7cf25f5a693c","type":"text","conversion_output":false,"parent_id":"50fa396697d347dcbe83ee5d471fd5ee","text":"Intelligence Scale","text_display":" Intelligence Scale","confidence":1,"confidence_rate":1},{"cnt":[[1094,1657],[1516,1657],[1516,1691],[1094,1691]],"region":{"top_left_x":1094,"top_left_y":1656,"width":422,"height":36},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"21feaed68e79483c84fa55538087d823","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Number of correctly coded digits","text_display":"Number of correctly coded digits","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1739],[945,1739],[945,1775],[443,1775]],"region":{"top_left_x":443,"top_left_y":1739,"width":502,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3dbc489ac77d48ed8201bde95efbcb6e","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Forward and Backward Digit Span test","text_display":"Forward and Backward Digit Span test","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1091,1738],[1732,1738],[1732,1808],[1091,1808]],"region":{"top_left_x":1091,"top_left_y":1737,"width":642,"height":72},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"203078fcd55849518e32a81b68512eca","type":"complex_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","children_ids":["c230534e8fde4f1596b32d2bafc7da6e","514e4824cbdf4be7be569e8ae8d3e3a0"],"text":"Maximum number of digits repeated, forward and backward scores","text_display":"Maximum number of digits repeated, forward and backward scores","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1739],[1729,1739],[1729,1775],[1094,1775]],"region":{"top_left_x":1094,"top_left_y":1739,"width":635,"height":37},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c230534e8fde4f1596b32d2bafc7da6e","type":"text","conversion_output":false,"parent_id":"203078fcd55849518e32a81b68512eca","text":"Maximum number of digits repeated, forward and","text_display":"Maximum number of digits repeated, forward and","confidence":1,"confidence_rate":1},{"cnt":[[1094,1775],[1316,1775],[1316,1806],[1094,1806]],"region":{"top_left_x":1094,"top_left_y":1775,"width":223,"height":32},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"514e4824cbdf4be7be569e8ae8d3e3a0","type":"text","conversion_output":false,"parent_id":"203078fcd55849518e32a81b68512eca","text":"backward scores","text_display":" backward scores","confidence":1,"confidence_rate":1},{"cnt":[[441,1822],[1024,1822],[1024,1860],[441,1860]],"region":{"top_left_x":441,"top_left_y":1821,"width":583,"height":39},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de789950ce3e49cbbcd43e6d82473daf","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Benton Judgment of Line Orientation, form V","text_display":"Benton Judgment of Line Orientation, form V","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99072265625,"confidence_rate":0.9998058387197919},{"cnt":[[1094,1825],[1244,1825],[1244,1856],[1094,1856]],"region":{"top_left_x":1094,"top_left_y":1825,"width":150,"height":32},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b0c320953bc42328d897305975a0c6e","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Total score","text_display":"Total score","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[441,1873],[701,1873],[701,1909],[441,1909]],"region":{"top_left_x":441,"top_left_y":1873,"width":260,"height":37},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"514200c3df5a462e82914d54168c0540","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Animal Naming test","text_display":"Animal Naming test","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1873],[1536,1873],[1536,1909],[1094,1909]],"region":{"top_left_x":1094,"top_left_y":1873,"width":443,"height":37},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f57f57bd43c74041b6c3af076688a404","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"Number of unique animals named","text_display":"Number of unique animals named","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,1922],[807,1922],[807,1958],[445,1958]],"region":{"top_left_x":444,"top_left_y":1921,"width":364,"height":37},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61ccb6d6dfc04e2dbbb15dd474346fd9","type":"simple_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","text":"15 -item Boston Naming test","text_display":"15 -item Boston Naming test","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.85107421875,"confidence_rate":0.9948117014198684},{"cnt":[[1091,1918],[1718,1918],[1718,1994],[1091,1994]],"region":{"top_left_x":1091,"top_left_y":1918,"width":628,"height":76},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4abf8af577e9485aa7630db1c3a7dc19","type":"complex_cell","conversion_output":false,"parent_id":"89719f19a0fb47fd8a17077023c137b3","children_ids":["4fa932adccc6459bbd065d444967e2a4","34f26bd7e1ef4e4abb14c1ad5dcc7738"],"text":"Total number of items answered correctly either spontaneously or after a stimulus cue","text_display":"Total number of items answered correctly either spontaneously or after a stimulus cue","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1922],[1713,1922],[1713,1958],[1094,1958]],"region":{"top_left_x":1094,"top_left_y":1921,"width":620,"height":37},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fa932adccc6459bbd065d444967e2a4","type":"text","conversion_output":false,"parent_id":"4abf8af577e9485aa7630db1c3a7dc19","text":"Total number of items answered correctly either","text_display":"Total number of items answered correctly either","confidence":1,"confidence_rate":1},{"cnt":[[1094,1958],[1581,1958],[1581,1992],[1094,1992]],"region":{"top_left_x":1094,"top_left_y":1957,"width":487,"height":35},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34f26bd7e1ef4e4abb14c1ad5dcc7738","type":"text","conversion_output":false,"parent_id":"4abf8af577e9485aa7630db1c3a7dc19","text":"spontaneously or after a stimulus cue","text_display":" spontaneously or after a stimulus cue","confidence":1,"confidence_rate":1},{"cnt":[[434,2101],[1699,2101],[1699,2146],[434,2146]],"region":{"top_left_x":433,"top_left_y":2101,"width":1267,"height":46},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b1f345f06f04aeebfd181a1adb4249b","type":"text","conversion_output":true,"text":"Outcomes from each test will be summarized by treatment group (mean, standard","text_display":"\n\nOutcomes from each test will be summarized by treatment group (mean, standard","confidence":1,"confidence_rate":1},{"cnt":[[434,2153],[1674,2153],[1674,2198],[434,2198]],"region":{"top_left_x":433,"top_left_y":2152,"width":1241,"height":46},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d5e0f9183484048b9b556d487bc9be7","type":"text","conversion_output":true,"text":"deviation, median, quartiles, minimum and maximum). Mean difference between","text_display":" deviation, median, quartiles, minimum and maximum). Mean difference between","confidence":1,"confidence_rate":1},{"cnt":[[434,2206],[1729,2206],[1729,2249],[434,2249]],"region":{"top_left_x":433,"top_left_y":2206,"width":1297,"height":44},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4ad0d33c3b24e8995af4c1a8ef699d3","type":"text","conversion_output":true,"text":"treatment groups with \\(95 \\%\\) unadjusted normal Cl will be presented. Reasons for the","text_display":" treatment groups with \\(95 \\%\\) unadjusted normal Cl will be presented. Reasons for the","confidence":0.5955058615654707,"confidence_rate":0.9945586051854921},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":62,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"271724d7b08a4a5d97e255a230d7d3c1","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[599,2368],[599,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":167,"height":33},"line":63,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"deb6d8e9a26f4e929d6dc6d2e0cda031","type":"page_info","conversion_output":false,"text":"22/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":64,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"df3e1d4475e548b4b0a3dd9e11b40fb8","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7cf75d5ac00b473eb12a3b50c12bd0e6","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9941506325279192,"confidence_rate":0.9999097495800716},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d33c7b512d7a4d9f95ea5ee1254a0f81","type":"page_info","conversion_output":false,"text":"783/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-24","page":24,"lines":[{"cnt":[[434,449],[1734,449],[1734,492],[434,492]],"region":{"top_left_x":433,"top_left_y":449,"width":1301,"height":43},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9856c2e9e5a54998b2c07562872f2328","type":"text","conversion_output":true,"text":"assessment not being performed will be summarized by the number and percentage","text_display":"\nassessment not being performed will be summarized by the number and percentage","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[703,498],[703,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":270,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"181d021406ab4f4bb4fc9daf347b4a55","type":"text","conversion_output":true,"text":"in each category.","text_display":" in each category.","confidence":1,"confidence_rate":1},{"cnt":[[296,580],[862,580],[862,638],[296,638]],"region":{"top_left_x":296,"top_left_y":580,"width":566,"height":59},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa2e7dc1a32943cfba69ab75a2955c4d","type":"section_header","conversion_output":false,"children_ids":["63f7bdfbe82140419636153ebd203292"],"text":"","text_display":""},{"cnt":[[301,587],[857,587],[857,632],[301,632]],"region":{"top_left_x":300,"top_left_y":586,"width":558,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63f7bdfbe82140419636153ebd203292","type":"text","conversion_output":true,"parent_id":"aa2e7dc1a32943cfba69ab75a2955c4d","text":"4.5.2 Ambulatory Performance","text_display":"\n\n\\subsection*{4.5.2 Ambulatory Performance}","confidence":1,"confidence_rate":1},{"cnt":[[432,653],[1620,653],[1620,698],[432,698]],"region":{"top_left_x":431,"top_left_y":653,"width":1189,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44cee9ed0de747dd9fb562ca625f0844","type":"text","conversion_output":true,"text":"The 10 meter walk test will be conducted at Day 90 visit to measure patient's","text_display":"\n\nThe 10 meter walk test will be conducted at Day 90 visit to measure patient's","confidence":1,"confidence_rate":1},{"cnt":[[434,705],[1714,705],[1714,752],[434,752]],"region":{"top_left_x":433,"top_left_y":704,"width":1282,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ef062060a16546fab91e53aa848b2ba0","type":"text","conversion_output":true,"text":"walking speed. The speed will be measured at a comfortable pace and a fast pace,","text_display":" walking speed. The speed will be measured at a comfortable pace and a fast pace,","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[434,758],[1635,758],[1635,806],[434,806]],"region":{"top_left_x":433,"top_left_y":758,"width":1202,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2694cb8001684920a1ab29267e6ff6c9","type":"text","conversion_output":true,"text":"giving two attempts for each pace level. Average speed from the two attempts","text_display":" giving two attempts for each pace level. Average speed from the two attempts","confidence":1,"confidence_rate":1},{"cnt":[[434,810],[1732,810],[1732,855],[434,855]],"region":{"top_left_x":433,"top_left_y":809,"width":1299,"height":47},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26f4c98492734871a41eda79c3b314b2","type":"text","conversion_output":true,"text":"obtained at each pace will be summarized descriptively by treatment group. If speed","text_display":" obtained at each pace will be summarized descriptively by treatment group. If speed","confidence":1,"confidence_rate":1},{"cnt":[[434,864],[1729,864],[1729,909],[434,909]],"region":{"top_left_x":433,"top_left_y":863,"width":1297,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df7b2f94df49467fbd0a7823e77f0535","type":"text","conversion_output":true,"text":"can only be calculated in one of the attempts at a pace level, this result will be used.","text_display":" can only be calculated in one of the attempts at a pace level, this result will be used.","confidence":1,"confidence_rate":1},{"cnt":[[432,956],[1717,956],[1717,1001],[432,1001]],"region":{"top_left_x":431,"top_left_y":956,"width":1286,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3e48b7ffc6048c0ba372b9627a4c275","type":"text","conversion_output":true,"text":"Average speeds will be summarized by treatment group (mean, standard deviation,","text_display":"\n\nAverage speeds will be summarized by treatment group (mean, standard deviation,","confidence":1,"confidence_rate":1},{"cnt":[[434,1005],[1674,1005],[1674,1051],[434,1051]],"region":{"top_left_x":433,"top_left_y":1005,"width":1241,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04c0698fde0446919967ac5b1a079d76","type":"text","conversion_output":true,"text":"median, quartiles, minimum and maximum). Mean difference between treatment","text_display":" median, quartiles, minimum and maximum). Mean difference between treatment","confidence":1,"confidence_rate":1},{"cnt":[[434,1059],[1571,1059],[1571,1102],[434,1102]],"region":{"top_left_x":433,"top_left_y":1059,"width":1138,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e67877c1a30841c091987c519699978b","type":"text","conversion_output":true,"text":"groups with \\(95 \\%\\) unadjusted normal CI will be presented. Reasons for the","text_display":" groups with \\(95 \\%\\) unadjusted normal CI will be presented. Reasons for the","confidence":0.4306983947753906,"confidence_rate":0.9893940212986895},{"cnt":[[434,1113],[1734,1113],[1734,1156],[434,1156]],"region":{"top_left_x":433,"top_left_y":1112,"width":1301,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"deeca19de82e47afb05d5851d515daf5","type":"text","conversion_output":true,"text":"assessment not being performed will be summarized by the number and percentage","text_display":" assessment not being performed will be summarized by the number and percentage","confidence":1,"confidence_rate":1},{"cnt":[[434,1164],[703,1164],[703,1210],[434,1210]],"region":{"top_left_x":433,"top_left_y":1164,"width":270,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9570e53f8e084085962896f270f8829a","type":"text","conversion_output":true,"text":"in each category.","text_display":" in each category.","confidence":1,"confidence_rate":1},{"cnt":[[296,1246],[904,1246],[904,1300],[296,1300]],"region":{"top_left_x":296,"top_left_y":1246,"width":609,"height":54},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eeb5b72db0d14dfbbbfadcfe39212efa","type":"section_header","conversion_output":false,"children_ids":["5f3facd3db6446aab457b3187cc3520e"],"text":"","text_display":""},{"cnt":[[303,1250],[896,1250],[896,1296],[303,1296]],"region":{"top_left_x":302,"top_left_y":1250,"width":594,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f3facd3db6446aab457b3187cc3520e","type":"text","conversion_output":true,"parent_id":"eeb5b72db0d14dfbbbfadcfe39212efa","text":"4.5.3 Patient Reported Outcomes","text_display":"\n\n\\subsection*{4.5.3 Patient Reported Outcomes}","confidence":0.9990236759185791,"confidence_rate":0.9999728670071003},{"cnt":[[434,1319],[1729,1319],[1729,1364],[434,1364]],"region":{"top_left_x":433,"top_left_y":1319,"width":1297,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fccac97cab14281a2cf907f638c587b","type":"text","conversion_output":true,"text":"The patient reported outcomes (PROs) for this study include the EQ-5D, the 16 item","text_display":"\n\nThe patient reported outcomes (PROs) for this study include the EQ-5D, the 16 item","confidence":1,"confidence_rate":1},{"cnt":[[434,1371],[1725,1371],[1725,1416],[434,1416]],"region":{"top_left_x":433,"top_left_y":1370,"width":1293,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06a9aecf9bc54a5289b95340c920e23d","type":"text","conversion_output":true,"text":"Stroke Impact Scale (SIS-16), and the Center for Epidemiologic Studies Depression","text_display":" Stroke Impact Scale (SIS-16), and the Center for Epidemiologic Studies Depression","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[434,1422],[677,1422],[677,1467],[434,1467]],"region":{"top_left_x":433,"top_left_y":1422,"width":244,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18b9759cca5b4e1fa02d8ae92f758258","type":"text","conversion_output":true,"text":"Scale (CES-D).","text_display":" Scale (CES-D).","confidence":1,"confidence_rate":1},{"cnt":[[425,1508],[668,1508],[668,1558],[425,1558]],"region":{"top_left_x":425,"top_left_y":1508,"width":244,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60e620756d5e4e9699e3d7bce69bf956","type":"section_header","conversion_output":false,"children_ids":["8fd2a6ef4f004b8f91b48f777a001ffd"],"text":"","text_display":""},{"cnt":[[434,1512],[660,1512],[660,1553],[434,1553]],"region":{"top_left_x":433,"top_left_y":1512,"width":227,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fd2a6ef4f004b8f91b48f777a001ffd","type":"text","conversion_output":true,"parent_id":"60e620756d5e4e9699e3d7bce69bf956","text":"4.5.3.1 EQ-5D","text_display":"\n\n\\subsection*{4.5.3.1 EQ-5D}","confidence":1,"confidence_rate":1},{"cnt":[[434,1575],[1648,1575],[1648,1618],[434,1618]],"region":{"top_left_x":433,"top_left_y":1574,"width":1215,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86f7ded55cd445afab43fa23fe7633f1","type":"text","conversion_output":true,"text":"Health-related quality of life will be assessed using the EQ-5D. The EQ-5D is a","text_display":"\n\nHealth-related quality of life will be assessed using the EQ-5D. The EQ-5D is a","confidence":1,"confidence_rate":1},{"cnt":[[434,1629],[1644,1629],[1644,1671],[434,1671]],"region":{"top_left_x":433,"top_left_y":1628,"width":1211,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc5c02a8615248f998a2e96142aa4573","type":"text","conversion_output":true,"text":"generic, preference-based health utility measure with questions about mobility,","text_display":" generic, preference-based health utility measure with questions about mobility,","confidence":1,"confidence_rate":1},{"cnt":[[434,1680],[1699,1680],[1699,1721],[434,1721]],"region":{"top_left_x":433,"top_left_y":1680,"width":1267,"height":41},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d47ca5969ff7427e82dafe075ecde4b4","type":"text","conversion_output":true,"text":"self-care, usual activities, pain/discomfort, and anxiety/depression that are used to","text_display":" self-care, usual activities, pain/discomfort, and anxiety/depression that are used to","confidence":1,"confidence_rate":1},{"cnt":[[434,1732],[1704,1732],[1704,1772],[434,1772]],"region":{"top_left_x":433,"top_left_y":1731,"width":1271,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1aa29523aab44e96ab1c71e186b69274","type":"text","conversion_output":true,"text":"build a composite of the patient's health status. The second component of the EQ-","text_display":" build a composite of the patient's health status. The second component of the EQ","confidence":1,"confidence_rate":1},{"cnt":[[434,1783],[1678,1783],[1678,1828],[434,1828]],"region":{"top_left_x":433,"top_left_y":1783,"width":1245,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"112a0cab4e6c47c7a9f3d386c7256e26","type":"text","conversion_output":true,"text":"5D is a visual analogue scale (VAS), asking patients to rate their health from 0 to","text_display":"5D is a visual analogue scale (VAS), asking patients to rate their health from 0 to","confidence":1,"confidence_rate":1},{"cnt":[[434,1835],[1689,1835],[1689,1880],[434,1880]],"region":{"top_left_x":433,"top_left_y":1834,"width":1256,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e404aa6a74540a1bf9229e86bb1548c","type":"text","conversion_output":true,"text":"100 where 0 represents the worst imaginable health state and 100 represents the","text_display":" 100 where 0 represents the worst imaginable health state and 100 represents the","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[434,1886],[881,1886],[881,1931],[434,1931]],"region":{"top_left_x":433,"top_left_y":1886,"width":448,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"571aca37f0ef46eaba06a5104b63e075","type":"text","conversion_output":true,"text":"best imaginable health state.","text_display":" best imaginable health state.","confidence":1,"confidence_rate":1},{"cnt":[[434,1981],[1695,1981],[1695,2024],[434,2024]],"region":{"top_left_x":433,"top_left_y":1980,"width":1263,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb4bea75e7dd46b4931805d8c6412889","type":"text","conversion_output":true,"text":"Each question is scored as 1 for no problem, 2 as some problem, and 3 indicating","text_display":"\n\nEach question is scored as 1 for no problem, 2 as some problem, and 3 indicating","confidence":1,"confidence_rate":1},{"cnt":[[434,2032],[1725,2032],[1725,2078],[434,2078]],"region":{"top_left_x":433,"top_left_y":2032,"width":1293,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ca556357a074041a67ebbc8dde77c11","type":"text","conversion_output":true,"text":"extreme problem. Ambiguous values (eg. 2 boxes are ticked for a single dimension)","text_display":" extreme problem. Ambiguous values (eg. 2 boxes are ticked for a single dimension)","confidence":1,"confidence_rate":1},{"cnt":[[434,2084],[1154,2084],[1154,2129],[434,2129]],"region":{"top_left_x":433,"top_left_y":2083,"width":721,"height":47},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af56ee4e44c349ce8dc09b3f0f52b3e9","type":"text","conversion_output":true,"text":"will be treated as missing (neither value used).","text_display":" will be treated as missing (neither value used).","confidence":1,"confidence_rate":1},{"cnt":[[434,2179],[1669,2179],[1669,2219],[434,2219]],"region":{"top_left_x":433,"top_left_y":2178,"width":1237,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88c44f17b5b14714ae9fe620fabec5a7","type":"text","conversion_output":true,"text":"The 5 scores will then be converted into a single summary index by applying the","text_display":"\n\nThe 5 scores will then be converted into a single summary index by applying the","confidence":1,"confidence_rate":1},{"cnt":[[434,2230],[1656,2230],[1656,2273],[434,2273]],"region":{"top_left_x":433,"top_left_y":2230,"width":1224,"height":44},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba3a583541dd4f6b9d45052890d23249","type":"text","conversion_output":true,"text":"time trade-off valuation technique for the US, published by EuroQol group. SAS","text_display":" time trade-off valuation technique for the US, published by EuroQol group. SAS","confidence":0.99951171875,"confidence_rate":0.999994115673962},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22507636dae04daa816c3ee34f77a092","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c44cdd615c84b95b43226372e05918c","type":"text","conversion_output":true,"text":"23/ML29093","text_display":"\n23/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cbee5ec88f54197aebb00b79b0fc1ae","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a8ca833f142649ea90cc2b3d117cc7da","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9902660462662425,"confidence_rate":0.9998495245786598},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb02db5e23954bbb8d6c27e933cd0b32","type":"page_info","conversion_output":false,"text":"784/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-25","page":25,"lines":[{"cnt":[[434,447],[1695,447],[1695,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1263,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b35187e3b36434389e5916941916fdb","type":"text","conversion_output":true,"text":"code to perform the calculation is provided in Appendix G. The resulting summary","text_display":"\ncode to perform the calculation is provided in Appendix G. The resulting summary","confidence":0.99853515625,"confidence_rate":0.9999827540583306},{"cnt":[[434,498],[1734,498],[1734,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1301,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1c0f355c5df49b3a6950c4361dda7c0","type":"text","conversion_output":true,"text":"index is a continuous variable ranging from -0.11 (i.e., 3 for all questions) to 1.0 (i.e.,","text_display":" index is a continuous variable ranging from -0.11 (i.e., 3 for all questions) to 1.0 (i.e.,","confidence":1,"confidence_rate":1},{"cnt":[[434,550],[1734,550],[1734,595],[434,595]],"region":{"top_left_x":433,"top_left_y":550,"width":1301,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46607e31d8c24e4bb3c3853f41df4960","type":"text","conversion_output":true,"text":"1 for all questions) on a scale where \\(0.0=\\) death and \\(1.0=\\) perfect health (18). If any","text_display":" 1 for all questions) on a scale where \\(0.0=\\) death and \\(1.0=\\) perfect health (18). If any","confidence":0.8932197093963623,"confidence_rate":0.9988120462478679},{"cnt":[[434,602],[1661,602],[1661,647],[434,647]],"region":{"top_left_x":433,"top_left_y":601,"width":1228,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fbda87cd7bb4286af0ddc2a59e4776b","type":"text","conversion_output":true,"text":"of the 5 scores are missing, the summary index will not be calculated and set to","text_display":" of the 5 scores are missing, the summary index will not be calculated and set to","confidence":1,"confidence_rate":1},{"cnt":[[434,655],[569,655],[569,698],[434,698]],"region":{"top_left_x":433,"top_left_y":655,"width":137,"height":44},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f515ae21e464b3bab121898a1d4846b","type":"text","conversion_output":true,"text":"missing.","text_display":" missing.","confidence":1,"confidence_rate":1},{"cnt":[[434,748],[1729,748],[1729,793],[434,793]],"region":{"top_left_x":433,"top_left_y":747,"width":1297,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e76aa49bb654032ba7c8cb05763db5a","type":"text","conversion_output":true,"text":"The VAS is scored by the crossing point of the VAS with the response line, or with a","text_display":"\n\nThe VAS is scored by the crossing point of the VAS with the response line, or with a","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[434,799],[1714,799],[1714,844],[434,844]],"region":{"top_left_x":433,"top_left_y":799,"width":1282,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82fec0c1d0844af097cb80ccc8fb69d0","type":"text","conversion_output":true,"text":"horizontal line extended from the end point of the response line. Ambiguous values","text_display":" horizontal line extended from the end point of the response line. Ambiguous values","confidence":1,"confidence_rate":1},{"cnt":[[434,851],[1394,851],[1394,896],[434,896]],"region":{"top_left_x":433,"top_left_y":850,"width":962,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2bc4888e25e41d1a9dae0724e7161ff","type":"text","conversion_output":true,"text":"(eg. the line crosses the VAS twice) will be treated as missing.","text_display":" (eg. the line crosses the VAS twice) will be treated as missing.","confidence":1,"confidence_rate":1},{"cnt":[[434,945],[1551,945],[1551,988],[434,988]],"region":{"top_left_x":433,"top_left_y":945,"width":1119,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a05b66f447fe4731addcb8e62c29c6da","type":"text","conversion_output":true,"text":"Scores to each question, the summary index, and the VAS result, will be","text_display":"\n\nScores to each question, the summary index, and the VAS result, will be","confidence":1,"confidence_rate":1},{"cnt":[[434,997],[1708,997],[1708,1040],[434,1040]],"region":{"top_left_x":433,"top_left_y":996,"width":1276,"height":44},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f39585c99364dd1ae3c32a8ad4ed5b1","type":"text","conversion_output":true,"text":"summarized descriptively, and the two-sided \\(95 \\% Cl\\) of the mean difference will be","text_display":" summarized descriptively, and the two-sided \\(95 \\% Cl\\) of the mean difference will be","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[434,1048],[952,1048],[952,1094],[434,1094]],"region":{"top_left_x":433,"top_left_y":1048,"width":519,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d8af0b3359bb4027accc18cc8333d6f0","type":"text","conversion_output":true,"text":"presented for the index and VAS.","text_display":" presented for the index and VAS.","confidence":1,"confidence_rate":1},{"cnt":[[425,1130],[1081,1130],[1081,1188],[425,1188]],"region":{"top_left_x":425,"top_left_y":1130,"width":656,"height":59},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8be195e6d2aa4af7965ae57d7b3b53a5","type":"section_header","conversion_output":false,"children_ids":["01f6921bb7ca40248c114b1a8e1fdb04"],"text":"","text_display":""},{"cnt":[[432,1137],[1076,1137],[1076,1184],[432,1184]],"region":{"top_left_x":431,"top_left_y":1136,"width":646,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01f6921bb7ca40248c114b1a8e1fdb04","type":"text","conversion_output":true,"parent_id":"8be195e6d2aa4af7965ae57d7b3b53a5","text":"4.5.3.2 Stroke Impact Scale-16 (SIS-16)","text_display":"\n\n\\subsection*{4.5.3.2 Stroke Impact Scale-16 (SIS-16)}","confidence":1,"confidence_rate":1},{"cnt":[[434,1199],[1727,1199],[1727,1244],[434,1244]],"region":{"top_left_x":433,"top_left_y":1198,"width":1295,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f605ba0b228b4a6d917d9a60266878a9","type":"text","conversion_output":true,"text":"Physical functioning will be evaluated using the SIS-16, which is a validated, stroke-","text_display":"\n\nPhysical functioning will be evaluated using the SIS-16, which is a validated, stroke","confidence":1,"confidence_rate":1},{"cnt":[[434,1250],[1704,1250],[1704,1296],[434,1296]],"region":{"top_left_x":433,"top_left_y":1250,"width":1271,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb7e4807a56f4961b85d074b79a16e3f","type":"text","conversion_output":true,"text":"specific, quality of life measure to assess the impact of stroke on a patient's health","text_display":"specific, quality of life measure to assess the impact of stroke on a patient's health","confidence":1,"confidence_rate":1},{"cnt":[[434,1302],[1708,1302],[1708,1347],[434,1347]],"region":{"top_left_x":433,"top_left_y":1301,"width":1276,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ce3f61e4de84ff7b5ced465ec92ccb3","type":"text","conversion_output":true,"text":"and life. Each of the 16 items is rated using the following scale: \\(1=\\) could not do at","text_display":" and life. Each of the 16 items is rated using the following scale: \\(1=\\) could not do at","confidence":0.9608383057639003,"confidence_rate":0.9995839496938008},{"cnt":[[434,1354],[1712,1354],[1712,1399],[434,1399]],"region":{"top_left_x":433,"top_left_y":1353,"width":1280,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f13dcb05ee647c6b52f9fe3b38427c1","type":"text","conversion_output":true,"text":"all; \\(2=\\) very difficult; \\(3=\\) somewhat difficult; \\(4=\\) a little difficult; \\(5=\\) not difficult at all.","text_display":" all; \\(2=\\) very difficult; \\(3=\\) somewhat difficult; \\(4=\\) a little difficult; \\(5=\\) not difficult at all.","confidence":0.8527517697668519,"confidence_rate":0.9985660130862554},{"cnt":[[434,1448],[1674,1448],[1674,1493],[434,1493]],"region":{"top_left_x":433,"top_left_y":1448,"width":1241,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6858aa9db64a4bfa900d56adeff81e52","type":"text","conversion_output":true,"text":"The physical domain score is obtained by averaging the non-missing responses,","text_display":"\n\nThe physical domain score is obtained by averaging the non-missing responses,","confidence":1,"confidence_rate":1},{"cnt":[[434,1500],[1609,1500],[1609,1545],[434,1545]],"region":{"top_left_x":433,"top_left_y":1499,"width":1177,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"999502a480454c1ab175f23b119c938e","type":"text","conversion_output":true,"text":"provided that 9 or more questions are answered. The score is calculated as:","text_display":" provided that 9 or more questions are answered. The score is calculated as:","confidence":0.9990234375,"confidence_rate":0.9999882285072625},{"cnt":[[808,1577],[1369,1577],[1369,1635],[808,1635]],"region":{"top_left_x":807,"top_left_y":1576,"width":562,"height":59},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"107c5a5ea43946d8b89776090d10f069","type":"math","conversion_output":true,"text":"\\[\n\\text { Score }=100 \\times[(\\text { Mean }-1) /(5-1)]\n\\]","text_display":"\n\\[\n\\text { Score }=100 \\times[(\\text { Mean }-1) /(5-1)]\n\\]","confidence":1,"confidence_rate":1},{"cnt":[[434,1674],[939,1674],[939,1717],[434,1717]],"region":{"top_left_x":433,"top_left_y":1673,"width":506,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12f3ab13d88b4528ad78194be0888a4b","type":"text","conversion_output":true,"text":"which ranges from 0 to 100 (19).","text_display":"\nwhich ranges from 0 to 100 (19).","confidence":0.99169921875,"confidence_rate":0.999806171703899},{"cnt":[[434,1766],[1721,1766],[1721,1809],[434,1809]],"region":{"top_left_x":433,"top_left_y":1766,"width":1288,"height":43},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf569975014a42db9167c006e45e37de","type":"text","conversion_output":true,"text":"Responses to individual questions and the physical domain score will be listed. The","text_display":"\n\nResponses to individual questions and the physical domain score will be listed. The","confidence":1,"confidence_rate":1},{"cnt":[[434,1818],[1704,1818],[1704,1863],[434,1863]],"region":{"top_left_x":433,"top_left_y":1817,"width":1271,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9e23bfd0a4747d789ca8604db169c2f","type":"text","conversion_output":true,"text":"domain score will be summarized by treatment group and the two-sided \\(95 \\% Cl\\) of","text_display":" domain score will be summarized by treatment group and the two-sided \\(95 \\% Cl\\) of","confidence":0.987326375907287,"confidence_rate":0.9998550716448178},{"cnt":[[434,1869],[1027,1869],[1027,1914],[434,1914]],"region":{"top_left_x":433,"top_left_y":1869,"width":594,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9974a15616f7424bbbaa41b00ae9ea0c","type":"text","conversion_output":true,"text":"the mean difference will be presented.","text_display":" the mean difference will be presented.","confidence":1,"confidence_rate":1},{"cnt":[[425,1953],[1549,1953],[1549,2009],[425,2009]],"region":{"top_left_x":425,"top_left_y":1952,"width":1125,"height":57},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7151c36ea054ff1befab08e7d24a6bd","type":"section_header","conversion_output":false,"children_ids":["ff5d49919af24e9e98570bd8dfc69702"],"text":"","text_display":""},{"cnt":[[432,1959],[1545,1959],[1545,2004],[432,2004]],"region":{"top_left_x":431,"top_left_y":1959,"width":1114,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff5d49919af24e9e98570bd8dfc69702","type":"text","conversion_output":true,"parent_id":"c7151c36ea054ff1befab08e7d24a6bd","text":"4.5.3.3 Center for Epidemiologic Studies Depression Scale (CES-D)","text_display":"\n\n\\subsection*{4.5.3.3 Center for Epidemiologic Studies Depression Scale (CES-D)}","confidence":0.9980478286743164,"confidence_rate":0.9999720849711223},{"cnt":[[434,2020],[1549,2020],[1549,2065],[434,2065]],"region":{"top_left_x":433,"top_left_y":2019,"width":1117,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c21f434386d4425f9843176c1aa5274e","type":"text","conversion_output":true,"text":"The CES-D is a short, self-report scale designed to measure depressive","text_display":"\n\nThe CES-D is a short, self-report scale designed to measure depressive","confidence":1,"confidence_rate":1},{"cnt":[[434,2073],[1691,2073],[1691,2116],[434,2116]],"region":{"top_left_x":433,"top_left_y":2073,"width":1258,"height":44},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"996d8dbfafa94579856ad80f8a192b62","type":"text","conversion_output":true,"text":"symptomatology. Responses to the 20 individual items will be scored to obtain an","text_display":" symptomatology. Responses to the 20 individual items will be scored to obtain an","confidence":1,"confidence_rate":1},{"cnt":[[434,2127],[1098,2127],[1098,2168],[434,2168]],"region":{"top_left_x":433,"top_left_y":2126,"width":665,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c23f3335eda14955a646e3b749423a47","type":"text","conversion_output":true,"text":"overall depression assessment, as follows.","text_display":" overall depression assessment, as follows.","confidence":1,"confidence_rate":1},{"cnt":[[434,2211],[1631,2211],[1631,2254],[434,2254]],"region":{"top_left_x":433,"top_left_y":2210,"width":1198,"height":44},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b9fd0040bf94006941241df8d0d2bd4","type":"text","conversion_output":true,"text":"1. Assign scores \\(0=\\) rarely or none of the time, \\(1=\\) some or little of the time,","text_display":"\n1. Assign scores \\(0=\\) rarely or none of the time, \\(1=\\) some or little of the time,","confidence":0.9990236759185791,"confidence_rate":0.999989024768136},{"cnt":[[494,2256],[1605,2256],[1605,2297],[494,2297]],"region":{"top_left_x":494,"top_left_y":2255,"width":1111,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dde47530bb04955831b2c59ca120dc0","type":"text","conversion_output":true,"text":"2 = occasionally or moderate amount of time, \\(3=\\) most or all of the time.","text_display":" 2 = occasionally or moderate amount of time, \\(3=\\) most or all of the time.","confidence":0.9665708599462732,"confidence_rate":0.9995697044139916},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba259cfea11841dea1edfb5fc6e896da","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b308ff1104c54076aeb354866f2a9502","type":"page_info","conversion_output":false,"text":"24/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d20a60e767f44f1a97ca71e535e1699","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23ad2b893cf94f6f8034000a32c2d6f2","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9956128537910441,"confidence_rate":0.9999323592419798},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2d7434274174c1ba4502b5a17049bf8","type":"page_info","conversion_output":false,"text":"785/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-26","page":26,"lines":[{"cnt":[[432,438],[1721,438],[1721,483],[432,483]],"region":{"top_left_x":431,"top_left_y":438,"width":1290,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b62be1ecf461457eac7807ec5bd063f8","type":"text","conversion_output":true,"text":"2. Reverse positive items by subtracting their score from 3 . Positive items are 4,8 ,","text_display":"\n2. Reverse positive items by subtracting their score from 3 . Positive items are 4,8 ,","confidence":0.9907531298538753,"confidence_rate":0.9999042325463947},{"cnt":[[486,486],[666,486],[666,526],[486,526]],"region":{"top_left_x":485,"top_left_y":485,"width":182,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9ca8ad8b26fd4717be85aa0a71943142","type":"text","conversion_output":true,"text":"12 , and 16.","text_display":" 12 , and 16.","confidence":0.7783695892430842,"confidence_rate":0.9834351436005331},{"cnt":[[434,546],[1704,546],[1704,591],[434,591]],"region":{"top_left_x":433,"top_left_y":545,"width":1271,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4cc177d42b14c6abd6b09ad37c5092e","type":"text","conversion_output":true,"text":"3. If 4 or fewer items are missing, sum the available item scores to determine the","text_display":"\n3. If 4 or fewer items are missing, sum the available item scores to determine the","confidence":1,"confidence_rate":1},{"cnt":[[494,591],[1549,591],[1549,634],[494,634]],"region":{"top_left_x":494,"top_left_y":590,"width":1056,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79f831d367c84623882c28fba7f1778c","type":"text","conversion_output":true,"text":"total score. If more than 4 items are missing, no score is calculated.","text_display":" total score. If more than 4 items are missing, no score is calculated.","confidence":1,"confidence_rate":1},{"cnt":[[434,683],[1687,683],[1687,724],[434,724]],"region":{"top_left_x":433,"top_left_y":683,"width":1254,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1c9fd7d555c4c358b9b487de1a15644","type":"text","conversion_output":true,"text":"The total score will be used to evaluate the proportion of patients with depressive","text_display":"\n\nThe total score will be used to evaluate the proportion of patients with depressive","confidence":1,"confidence_rate":1},{"cnt":[[434,735],[1622,735],[1622,778],[434,778]],"region":{"top_left_x":433,"top_left_y":734,"width":1190,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7639490681944c58998623dc0ca963f4","type":"text","conversion_output":true,"text":"symptoms (defined as a score of \\(\\geq 16\\) at 90 days) and will be summarized by","text_display":" symptoms (defined as a score of \\(\\geq 16\\) at 90 days) and will be summarized by","confidence":1,"confidence_rate":1},{"cnt":[[434,786],[694,786],[694,827],[434,827]],"region":{"top_left_x":433,"top_left_y":786,"width":261,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0126f0143ace4dccac5ffc3428e88209","type":"text","conversion_output":true,"text":"treatment group.","text_display":" treatment group.","confidence":1,"confidence_rate":1},{"cnt":[[434,879],[1695,879],[1695,922],[434,922]],"region":{"top_left_x":433,"top_left_y":878,"width":1263,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68b4b24d1da64bc89e5a4e08e765011e","type":"text","conversion_output":true,"text":"Observed percentages and adjusted odds ratio will be presented. The adjustment","text_display":"\n\nObserved percentages and adjusted odds ratio will be presented. The adjustment","confidence":1,"confidence_rate":1},{"cnt":[[434,932],[1631,932],[1631,973],[434,973]],"region":{"top_left_x":433,"top_left_y":932,"width":1198,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13b46fc8cb10401e85f5262c0c254737","type":"text","conversion_output":true,"text":"will be performed in the same way as for the exploratory analysis of \\(mRS 0-1\\).","text_display":" will be performed in the same way as for the exploratory analysis of \\(mRS 0-1\\).","confidence":0.6816051242979597,"confidence_rate":0.99565373626242},{"cnt":[[329,1014],[780,1014],[780,1059],[329,1059]],"region":{"top_left_x":328,"top_left_y":1014,"width":452,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fda557b50a8b437d9c2f88656b7b7358","type":"section_header","conversion_output":false,"children_ids":["a495825e79ea476a928c2a52920429be"],"text":"","text_display":""},{"cnt":[[331,1018],[776,1018],[776,1055],[331,1055]],"region":{"top_left_x":330,"top_left_y":1018,"width":446,"height":37},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a495825e79ea476a928c2a52920429be","type":"text","conversion_output":true,"parent_id":"fda557b50a8b437d9c2f88656b7b7358","text":"4.6 SAFETY ANALYSES","text_display":"\n\n\\subsection*{4.6 SAFETY ANALYSES}","confidence":0.9990236759185791,"confidence_rate":0.9999593007867263},{"cnt":[[434,1087],[1622,1087],[1622,1128],[434,1128]],"region":{"top_left_x":433,"top_left_y":1087,"width":1190,"height":41},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2a1d16c098042d3861ce1321b7453af","type":"text","conversion_output":true,"text":"MedDRA (using the latest version at the time of reporting) will be used as the","text_display":"\n\nMedDRA (using the latest version at the time of reporting) will be used as the","confidence":1,"confidence_rate":1},{"cnt":[[434,1139],[1680,1139],[1680,1182],[434,1182]],"region":{"top_left_x":433,"top_left_y":1138,"width":1248,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c3af2257e92441ba14750285896167f","type":"text","conversion_output":true,"text":"thesaurus for AEs and diseases, and the World Health Organization (WHO) drug","text_display":" thesaurus for AEs and diseases, and the World Health Organization (WHO) drug","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[434,1190],[1678,1190],[1678,1235],[434,1235]],"region":{"top_left_x":433,"top_left_y":1190,"width":1245,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25fb5ceac8404c0c970bbda732b1646e","type":"text","conversion_output":true,"text":"dictionary will be used for treatments and MedDRA for procedures. A glossary of","text_display":" dictionary will be used for treatments and MedDRA for procedures. A glossary of","confidence":1,"confidence_rate":1},{"cnt":[[434,1242],[896,1242],[896,1287],[434,1287]],"region":{"top_left_x":433,"top_left_y":1241,"width":463,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0d6441ce027423caa2798257ab8b7e0","type":"text","conversion_output":true,"text":"these codes will be produced.","text_display":" these codes will be produced.","confidence":1,"confidence_rate":1},{"cnt":[[434,1336],[1712,1336],[1712,1377],[434,1377]],"region":{"top_left_x":433,"top_left_y":1336,"width":1280,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f04432cdfc2412ab2f587e0f7a0b5cb","type":"text","conversion_output":true,"text":"AEs with onset prior to initiation of study treatment which do not worsen after study","text_display":"\n\nAEs with onset prior to initiation of study treatment which do not worsen after study","confidence":1,"confidence_rate":1},{"cnt":[[434,1388],[1669,1388],[1669,1431],[434,1431]],"region":{"top_left_x":433,"top_left_y":1387,"width":1237,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c1435509d754fa8b336b3e558de19e9","type":"text","conversion_output":true,"text":"treatment or with onset after Day 90 assessment, will be listed as non-treatment","text_display":" treatment or with onset after Day 90 assessment, will be listed as non-treatment","confidence":1,"confidence_rate":1},{"cnt":[[434,1439],[1343,1439],[1343,1485],[434,1485]],"region":{"top_left_x":433,"top_left_y":1439,"width":910,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2294a40a1b84e8292197beb3806baf9","type":"text","conversion_output":true,"text":"emergent and will not be included in the safety summaries.","text_display":" emergent and will not be included in the safety summaries.","confidence":1,"confidence_rate":1},{"cnt":[[299,1523],[943,1523],[943,1575],[299,1575]],"region":{"top_left_x":298,"top_left_y":1523,"width":646,"height":52},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2c182197d8d46d78d97abf56c752f20","type":"section_header","conversion_output":false,"children_ids":["67e7adb2c3fd4a9aa27a83795caba130"],"text":"","text_display":""},{"cnt":[[305,1530],[939,1530],[939,1571],[305,1571]],"region":{"top_left_x":305,"top_left_y":1529,"width":634,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67e7adb2c3fd4a9aa27a83795caba130","type":"text","conversion_output":true,"parent_id":"d2c182197d8d46d78d97abf56c752f20","text":"4.6.1 Exposure to Study Medication","text_display":"\n\n\\subsection*{4.6.1 Exposure to Study Medication}","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[434,1594],[1562,1594],[1562,1639],[434,1639]],"region":{"top_left_x":433,"top_left_y":1594,"width":1129,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79c4df0886484787a5aa770dcff876b3","type":"text","conversion_output":true,"text":"Exposure data will be listed for both study drugs. The listing will show the","text_display":"\n\nExposure data will be listed for both study drugs. The listing will show the","confidence":1,"confidence_rate":1},{"cnt":[[434,1646],[1433,1646],[1433,1691],[434,1691]],"region":{"top_left_x":433,"top_left_y":1645,"width":1001,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de6eed3c544f479fa097ab91a462149e","type":"text","conversion_output":true,"text":"randomized treatment as well as the treatment actually received.","text_display":" randomized treatment as well as the treatment actually received.","confidence":1,"confidence_rate":1},{"cnt":[[434,1740],[1644,1740],[1644,1783],[434,1783]],"region":{"top_left_x":433,"top_left_y":1740,"width":1211,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10a1a7399b1b4be7b2777f91e0357cdf","type":"text","conversion_output":true,"text":"A summary of exposure to alteplase/alteplase placebo will be produced for the","text_display":"\n\nA summary of exposure to alteplase/alteplase placebo will be produced for the","confidence":1,"confidence_rate":1},{"cnt":[[434,1792],[1626,1792],[1626,1837],[434,1837]],"region":{"top_left_x":433,"top_left_y":1791,"width":1194,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"226d4b168afb4d9c874af69bee09d65d","type":"text","conversion_output":true,"text":"safety population. The total dose administered and duration of infusion will be","text_display":" safety population. The total dose administered and duration of infusion will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1843],[1708,1843],[1708,1888],[434,1888]],"region":{"top_left_x":433,"top_left_y":1843,"width":1276,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"960cb5c652a1496aa5dfa6da2053d510","type":"text","conversion_output":true,"text":"summarized by active or placebo Alteplase, as actually received. For Aspirin, dose","text_display":" summarized by active or placebo Alteplase, as actually received. For Aspirin, dose","confidence":1,"confidence_rate":1},{"cnt":[[434,1895],[1540,1895],[1540,1940],[434,1940]],"region":{"top_left_x":433,"top_left_y":1894,"width":1108,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"996fad75f62641c0906bbf989c8eabd9","type":"text","conversion_output":true,"text":"received will always be \" 325 mg \", and therefore will not be summarized.","text_display":" received will always be \" 325 mg \", and therefore will not be summarized.","confidence":0.99658203125,"confidence_rate":0.9999587499670765},{"cnt":[[434,1989],[1742,1989],[1742,2032],[434,2032]],"region":{"top_left_x":433,"top_left_y":1989,"width":1310,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8437b11584645cdb4b79f1f0427e0fa","type":"text","conversion_output":true,"text":"Compliance with study medications will be summarized for the safety population. For","text_display":"\n\nCompliance with study medications will be summarized for the safety population. For","confidence":1,"confidence_rate":1},{"cnt":[[434,2041],[1708,2041],[1708,2086],[434,2086]],"region":{"top_left_x":433,"top_left_y":2041,"width":1276,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"caba0e7b8a6844cd87016c3f3c6a22e6","type":"text","conversion_output":true,"text":"Alteplase, counts of infusion altered or stopped prematurely will be tabulated along","text_display":" Alteplase, counts of infusion altered or stopped prematurely will be tabulated along","confidence":1,"confidence_rate":1},{"cnt":[[434,2093],[1691,2093],[1691,2138],[434,2138]],"region":{"top_left_x":433,"top_left_y":2092,"width":1258,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc8caa5e67a64af08a3dc416d150397d","type":"text","conversion_output":true,"text":"with the reason. For aspirin, the number of patients who did not take study aspirin","text_display":" with the reason. For aspirin, the number of patients who did not take study aspirin","confidence":1,"confidence_rate":1},{"cnt":[[434,2144],[1132,2144],[1132,2189],[434,2189]],"region":{"top_left_x":433,"top_left_y":2144,"width":700,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecc57f9cf31c45a1981fd52483484371","type":"text","conversion_output":true,"text":"and a summary of reasons will be presented.","text_display":" and a summary of reasons will be presented.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8d6b819d3c841f591167e616e25f6fc","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a156d9575bef4c309d160150938c3180","type":"page_info","conversion_output":false,"text":"25/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79e55d51da5a4c79bb4cdb84e752b5af","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a86bdc02c8147859af5ea8b237d615c","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9951250501919731,"confidence_rate":0.9999248201932889},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97e6d785f1814ba988b18a7159c3b20d","type":"page_info","conversion_output":false,"text":"786/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-27","page":27,"lines":[{"cnt":[[301,443],[703,443],[703,483],[301,483]],"region":{"top_left_x":300,"top_left_y":442,"width":403,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1cc4a1cd3848450ebe0d711098d01de7","type":"section_header","conversion_output":false,"children_ids":["501d2211db5f475499d1b02d48225f0d"],"text":"","text_display":""},{"cnt":[[305,447],[698,447],[698,479],[305,479]],"region":{"top_left_x":305,"top_left_y":446,"width":394,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"501d2211db5f475499d1b02d48225f0d","type":"text","conversion_output":true,"parent_id":"1cc4a1cd3848450ebe0d711098d01de7","text":"4.6.2 Adverse Events","text_display":"\n\n\\subsection*{4.6.2 Adverse Events}","confidence":1,"confidence_rate":1},{"cnt":[[434,511],[1010,511],[1010,552],[434,552]],"region":{"top_left_x":433,"top_left_y":511,"width":577,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47a58a8cea3b4e72a2b6f99822b31dd4","type":"text","conversion_output":true,"text":"AE safety endpoints in this study are:","text_display":"\n\nAE safety endpoints in this study are:","confidence":1,"confidence_rate":1},{"cnt":[[434,597],[1695,597],[1695,638],[434,638]],"region":{"top_left_x":433,"top_left_y":597,"width":1263,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbda6affc2dd465bae3c1376515f056a","type":"text","conversion_output":true,"text":"- Number and percentage of patients experiencing serious and non-serious AEs","text_display":"\n- Number and percentage of patients experiencing serious and non-serious AEs","confidence":1,"confidence_rate":1},{"cnt":[[486,645],[883,645],[883,683],[486,683]],"region":{"top_left_x":485,"top_left_y":644,"width":399,"height":40},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9b6ada9c28d4ec6808b3369b80cc5f2","type":"text","conversion_output":true,"text":"after receiving study drug","text_display":" after receiving study drug","confidence":1,"confidence_rate":1},{"cnt":[[434,705],[1738,705],[1738,746],[434,746]],"region":{"top_left_x":433,"top_left_y":704,"width":1306,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"143ca51fb0454b5588a37a703029bd64","type":"text","conversion_output":true,"text":"- Number and percentage of patients experiencing serious and non-serious AEs of","text_display":"\n- Number and percentage of patients experiencing serious and non-serious AEs of","confidence":1,"confidence_rate":1},{"cnt":[[486,750],[726,750],[726,788],[486,788]],"region":{"top_left_x":485,"top_left_y":749,"width":242,"height":40},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12fd958249e84e4e89ec6cc9204607bd","type":"text","conversion_output":true,"text":"special interest","text_display":" special interest","confidence":1,"confidence_rate":1},{"cnt":[[434,821],[1678,821],[1678,862],[434,862]],"region":{"top_left_x":433,"top_left_y":820,"width":1245,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ae21d71be4b4adab9721280dfcf1d16","type":"text","conversion_output":true,"text":"AEs will be coded (using the latest MedDRA version at the time of reporting) and","text_display":"\n\nAEs will be coded (using the latest MedDRA version at the time of reporting) and","confidence":1,"confidence_rate":1},{"cnt":[[434,872],[1738,872],[1738,913],[434,913]],"region":{"top_left_x":433,"top_left_y":872,"width":1306,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00ab423e18d54483a1c20231d55300d5","type":"text","conversion_output":true,"text":"tabulated by system organ class (SOC); individual events within each SOC coded as","text_display":" tabulated by system organ class (SOC); individual events within each SOC coded as","confidence":1,"confidence_rate":1},{"cnt":[[434,924],[1588,924],[1588,965],[434,965]],"region":{"top_left_x":433,"top_left_y":923,"width":1155,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14e31e073f494242850f197804ecdf3a","type":"text","conversion_output":true,"text":"preferred terms will be presented in descending frequency using the safety","text_display":" preferred terms will be presented in descending frequency using the safety","confidence":1,"confidence_rate":1},{"cnt":[[434,975],[1717,975],[1717,1016],[434,1016]],"region":{"top_left_x":433,"top_left_y":975,"width":1284,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"13aab60b1eaf4ab58063a5c2103d4d65","type":"text","conversion_output":true,"text":"population. Treatment groups will be summarized according to the actual treatment","text_display":" population. Treatment groups will be summarized according to the actual treatment","confidence":0.99951171875,"confidence_rate":0.9999943209405665},{"cnt":[[434,1027],[578,1027],[578,1063],[434,1063]],"region":{"top_left_x":433,"top_left_y":1026,"width":145,"height":38},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44005168902a42a5a8ca070a822537fa","type":"text","conversion_output":true,"text":"received.","text_display":" received.","confidence":1,"confidence_rate":1},{"cnt":[[434,1121],[1693,1121],[1693,1162],[434,1162]],"region":{"top_left_x":433,"top_left_y":1121,"width":1260,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25aba590cc644162b2b1d89dc905e98b","type":"text","conversion_output":true,"text":"AEs will also be tabulated by intensity (severity) and relationship to study drug, as","text_display":"\n\nAEs will also be tabulated by intensity (severity) and relationship to study drug, as","confidence":1,"confidence_rate":1},{"cnt":[[434,1173],[1706,1173],[1706,1214],[434,1214]],"region":{"top_left_x":433,"top_left_y":1173,"width":1273,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15952b75cef54bfaa9e2aed0184c199d","type":"text","conversion_output":true,"text":"indicated by the investigator. Intensity of AEs will be graded according to the WHO","text_display":" indicated by the investigator. Intensity of AEs will be graded according to the WHO","confidence":1,"confidence_rate":1},{"cnt":[[434,1225],[1596,1225],[1596,1265],[434,1265]],"region":{"top_left_x":433,"top_left_y":1224,"width":1164,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"878d89bde90e45cfa40c1bae7a0b1f18","type":"text","conversion_output":true,"text":"Toxicity Grading Scale for Determining the Severity of Adverse Events (see","text_display":" Toxicity Grading Scale for Determining the Severity of Adverse Events (see","confidence":0.99951171875,"confidence_rate":0.999993817734324},{"cnt":[[434,1276],[1712,1276],[1712,1317],[434,1317]],"region":{"top_left_x":433,"top_left_y":1276,"width":1280,"height":41},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bb5e83303694b85b6cdfb082873dd88","type":"text","conversion_output":true,"text":"Appendix 14 of the protocol). Incidence and severity of AEs will be described for all","text_display":" Appendix 14 of the protocol). Incidence and severity of AEs will be described for all","confidence":1,"confidence_rate":1},{"cnt":[[434,1328],[1519,1328],[1519,1369],[434,1369]],"region":{"top_left_x":433,"top_left_y":1327,"width":1086,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"750e73d2e6204c78a061574040cbfe79","type":"text","conversion_output":true,"text":"treated patients by treatment group and by the MedDRA classification.","text_display":" treated patients by treatment group and by the MedDRA classification.","confidence":1,"confidence_rate":1},{"cnt":[[434,1422],[1736,1422],[1736,1463],[434,1463]],"region":{"top_left_x":433,"top_left_y":1422,"width":1303,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41eb75d6b9684e72bdb1aba053e1fc9c","type":"text","conversion_output":true,"text":"A summary of incidence rates of all deaths and stroke-related or neurological deaths","text_display":"\n\nA summary of incidence rates of all deaths and stroke-related or neurological deaths","confidence":1,"confidence_rate":1},{"cnt":[[434,1474],[1579,1474],[1579,1515],[434,1515]],"region":{"top_left_x":433,"top_left_y":1473,"width":1147,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bb0bc4499e045d785b64bda4bf3c5e0","type":"text","conversion_output":true,"text":"will be presented. Cumulative incidence of all deaths and stroke-related or","text_display":" will be presented. Cumulative incidence of all deaths and stroke-related or","confidence":1,"confidence_rate":1},{"cnt":[[434,1525],[1687,1525],[1687,1566],[434,1566]],"region":{"top_left_x":433,"top_left_y":1525,"width":1254,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3bc10ee39328470eb577598154c35964","type":"text","conversion_output":true,"text":"neurological deaths will be presented by means of Kaplan-Meier plots if there are","text_display":" neurological deaths will be presented by means of Kaplan-Meier plots if there are","confidence":1,"confidence_rate":1},{"cnt":[[434,1577],[1091,1577],[1091,1618],[434,1618]],"region":{"top_left_x":433,"top_left_y":1576,"width":659,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fbfcb958095405596a7b1ee9d4062e0","type":"text","conversion_output":true,"text":"sufficient events (at least 5 in each group).","text_display":" sufficient events (at least 5 in each group).","confidence":1,"confidence_rate":1},{"cnt":[[434,1671],[1575,1671],[1575,1712],[434,1712]],"region":{"top_left_x":433,"top_left_y":1671,"width":1142,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce0d38d14f2e42b693e25735321d77fa","type":"text","conversion_output":true,"text":"Timing of the AEs relative to Day 30 and Day 90 will be determined, using","text_display":"\n\nTiming of the AEs relative to Day 30 and Day 90 will be determined, using","confidence":1,"confidence_rate":1},{"cnt":[[434,1723],[1575,1723],[1575,1764],[434,1764]],"region":{"top_left_x":433,"top_left_y":1723,"width":1142,"height":41},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"014984dacb5141a59adbdd641228006f","type":"text","conversion_output":true,"text":"imputation for partial AE start and stop dates if necessary, as described in","text_display":" imputation for partial AE start and stop dates if necessary, as described in","confidence":1,"confidence_rate":1},{"cnt":[[434,1775],[1721,1775],[1721,1815],[434,1815]],"region":{"top_left_x":433,"top_left_y":1774,"width":1288,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa02102467494b64916e5c21f8781831","type":"text","conversion_output":true,"text":"Appendix D. AEs occurring after receipt of any study medication and before Day 90","text_display":" Appendix D. AEs occurring after receipt of any study medication and before Day 90","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[434,1826],[1699,1826],[1699,1867],[434,1867]],"region":{"top_left_x":433,"top_left_y":1826,"width":1267,"height":41},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5f0f19649cd48838892410eac008559","type":"text","conversion_output":true,"text":"will be summarized. AEs leading to IV study drug modification will be listed. SAEs,","text_display":" will be summarized. AEs leading to IV study drug modification will be listed. SAEs,","confidence":1,"confidence_rate":1},{"cnt":[[434,1878],[1712,1878],[1712,1919],[434,1919]],"region":{"top_left_x":433,"top_left_y":1877,"width":1280,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a7eb658d5e1427ebfe198de7ec766af","type":"text","conversion_output":true,"text":"ICH, AEs of special interest and AEs leading to study treatment discontinuation will","text_display":" ICH, AEs of special interest and AEs leading to study treatment discontinuation will","confidence":1,"confidence_rate":1},{"cnt":[[434,1929],[1712,1929],[1712,1972],[434,1972]],"region":{"top_left_x":433,"top_left_y":1929,"width":1280,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce15228c2efb4de9a6fcc4d388004ffd","type":"text","conversion_output":true,"text":"be summarized through Day 90. In addition, non-serious AEs within 30 days will be","text_display":" be summarized through Day 90. In addition, non-serious AEs within 30 days will be","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[434,1981],[638,1981],[638,2017],[434,2017]],"region":{"top_left_x":433,"top_left_y":1980,"width":206,"height":38},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ca6ed30aee14fa081f534270434bebe","type":"text","conversion_output":true,"text":"summarized.","text_display":" summarized.","confidence":1,"confidence_rate":1},{"cnt":[[430,2067],[1222,2067],[1222,2112],[430,2112]],"region":{"top_left_x":429,"top_left_y":2066,"width":794,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0993f858891644648eeb21d738ea4b90","type":"section_header","conversion_output":false,"children_ids":["4ef95ca7c3ef44fdb39a3d79ce309c0e"],"text":"","text_display":""},{"cnt":[[434,2071],[1218,2071],[1218,2110],[434,2110]],"region":{"top_left_x":433,"top_left_y":2071,"width":786,"height":39},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ef95ca7c3ef44fdb39a3d79ce309c0e","type":"text","conversion_output":true,"parent_id":"0993f858891644648eeb21d738ea4b90","text":"4.6.2.2 Adverse Events of Special Interest","text_display":"\n\n\\subsection*{4.6.2.2 Adverse Events of Special Interest}","confidence":1,"confidence_rate":1},{"cnt":[[434,2131],[1687,2131],[1687,2172],[434,2172]],"region":{"top_left_x":433,"top_left_y":2131,"width":1254,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c372a0affad44819b0c4472bb2065dd8","type":"text","conversion_output":true,"text":"Non-serious AESIs are required to be reported by the investigator to the Sponsor","text_display":"\n\nNon-serious AESIs are required to be reported by the investigator to the Sponsor","confidence":1,"confidence_rate":1},{"cnt":[[434,2183],[1665,2183],[1665,2224],[434,2224]],"region":{"top_left_x":433,"top_left_y":2182,"width":1233,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aabe2447b3f041a081c8c21740a95419","type":"text","conversion_output":true,"text":"immediately (i.e., no more than 24 hours after learning of the event; see Section","text_display":" immediately (i.e., no more than 24 hours after learning of the event; see Section","confidence":1,"confidence_rate":1},{"cnt":[[434,2237],[1089,2237],[1089,2277],[434,2277]],"region":{"top_left_x":433,"top_left_y":2236,"width":657,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af2ac5c7e8d54c57a3f6e4d4ce32d8b7","type":"text","conversion_output":true,"text":"5.4.2 of protocol for reporting instructions).","text_display":" 5.4.2 of protocol for reporting instructions).","confidence":0.99658203125,"confidence_rate":0.9999328684622548},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddf46e5fcda84d749f6954dcd391f3a9","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1182,2368],[1182,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":749,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e6547c3579b3415fa6a54683af52c33a","type":"page_info","conversion_output":false,"text":"26/ML29093 5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"678b47e6a74142dfa2e0702ea7024803","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922086966757888,"confidence_rate":0.9998796716383385},{"cnt":[[374,2608],[692,2608],[692,2643],[374,2643]],"region":{"top_left_x":373,"top_left_y":2608,"width":319,"height":35},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"026655ac6f634f4ca31e051a1b0aa4c9","type":"page_info","conversion_output":false,"text":"787/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-28","page":28,"lines":[{"cnt":[[434,447],[1074,447],[1074,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":642,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73de95dc7f274d2091c77fd410ec8abe","type":"text","conversion_output":true,"text":"AESIs for this study include the following:","text_display":"\n\nAESIs for this study include the following:","confidence":1,"confidence_rate":1},{"cnt":[[434,535],[1695,535],[1695,578],[434,578]],"region":{"top_left_x":433,"top_left_y":534,"width":1263,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f4c12c96a3646db9cfacef9d6fdabf3","type":"text","conversion_output":true,"text":"- sICH events, if not already reported as an SAE (for a list of preferred terms for","text_display":"\n- sICH events, if not already reported as an SAE (for a list of preferred terms for","confidence":1,"confidence_rate":1},{"cnt":[[486,576],[1008,576],[1008,621],[486,621]],"region":{"top_left_x":485,"top_left_y":575,"width":523,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44366abbb969419c93c3d41574c39a13","type":"text","conversion_output":true,"text":"ICH see Appendix 13 of protocol)","text_display":" ICH see Appendix 13 of protocol)","confidence":1,"confidence_rate":1},{"cnt":[[434,640],[1313,640],[1313,685],[434,685]],"region":{"top_left_x":433,"top_left_y":640,"width":880,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7b02a28cc2b4f02959ef6c694d39289","type":"text","conversion_output":true,"text":"- Stroke recurrence, if not already reported as an SAE.","text_display":"\n- Stroke recurrence, if not already reported as an SAE.","confidence":1,"confidence_rate":1},{"cnt":[[486,683],[1594,683],[1594,724],[486,724]],"region":{"top_left_x":485,"top_left_y":683,"width":1110,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80bf7dd46b4f435f86691a14d1485f6f","type":"text","conversion_output":true,"text":"Stroke recurrence is defined as a new ischemic stroke based on the AE","text_display":" Stroke recurrence is defined as a new ischemic stroke based on the AE","confidence":0.3735959529876709,"confidence_rate":0.9871285495433638},{"cnt":[[486,726],[1669,726],[1669,771],[486,771]],"region":{"top_left_x":485,"top_left_y":726,"width":1185,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a9137e90ec64818902ac713ba5982eb","type":"text","conversion_output":true,"text":"reporting. Stroke events will be identified through a medical review of the \\(A E\\)","text_display":" reporting. Stroke events will be identified through a medical review of the \\(A E\\)","confidence":0.5090177059173584,"confidence_rate":0.9917987847636636},{"cnt":[[486,769],[741,769],[741,814],[486,814]],"region":{"top_left_x":485,"top_left_y":769,"width":257,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bd6d792c7084cc18d1be03261957d49","type":"text","conversion_output":true,"text":"preferred terms.","text_display":" preferred terms.","confidence":1,"confidence_rate":1},{"cnt":[[432,834],[1592,834],[1592,879],[432,879]],"region":{"top_left_x":431,"top_left_y":833,"width":1161,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddde27593c544b438bec02f5b2f2ef71","type":"text","conversion_output":true,"text":"- Suspected Transmission of an Infectious Agent via a Medicinal Product","text_display":"\n- Suspected Transmission of an Infectious Agent via a Medicinal Product","confidence":1,"confidence_rate":1},{"cnt":[[486,877],[1463,877],[1463,922],[486,922]],"region":{"top_left_x":485,"top_left_y":876,"width":979,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"724b048079ce45bc805a484a04da7a7a","type":"text","conversion_output":true,"text":"(STIAMP) by the study drug, if not already reported as an SAE.","text_display":" (STIAMP) by the study drug, if not already reported as an SAE.","confidence":1,"confidence_rate":1},{"cnt":[[432,947],[1712,947],[1712,995],[432,995]],"region":{"top_left_x":431,"top_left_y":947,"width":1282,"height":48},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33a96c97826845cba6ac8d0764e0a22e","type":"text","conversion_output":true,"text":"AESIs will be tabulated by SOC and preferred term within SOC by treatment group","text_display":"\n\nAESIs will be tabulated by SOC and preferred term within SOC by treatment group","confidence":0.9990234375,"confidence_rate":0.9999883686432659},{"cnt":[[434,999],[866,999],[866,1044],[434,1044]],"region":{"top_left_x":433,"top_left_y":999,"width":433,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ccde34e6b50436e9876f0977a88187e","type":"text","conversion_output":true,"text":"using the safety population.","text_display":" using the safety population.","confidence":1,"confidence_rate":1},{"cnt":[[299,1083],[681,1083],[681,1137],[299,1137]],"region":{"top_left_x":298,"top_left_y":1082,"width":384,"height":55},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48eb8db03308455f95c4854c0477fb45","type":"section_header","conversion_output":false,"children_ids":["38dba04de8024760ae8cf0697eff5351"],"text":"","text_display":""},{"cnt":[[305,1087],[677,1087],[677,1132],[305,1132]],"region":{"top_left_x":305,"top_left_y":1087,"width":372,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38dba04de8024760ae8cf0697eff5351","type":"text","conversion_output":true,"parent_id":"48eb8db03308455f95c4854c0477fb45","text":"4.6.3 Neuroimaging","text_display":"\n\n\\subsection*{4.6.3 Neuroimaging}","confidence":1,"confidence_rate":1},{"cnt":[[434,1156],[1601,1156],[1601,1201],[434,1201]],"region":{"top_left_x":433,"top_left_y":1155,"width":1168,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee99662cb5d54f1d8e20c05cd1c5d1c7","type":"text","conversion_output":true,"text":"Neuroimaging may consist of a non-contrast computed tomography (CT) or","text_display":"\n\nNeuroimaging may consist of a non-contrast computed tomography (CT) or","confidence":1,"confidence_rate":1},{"cnt":[[434,1207],[1661,1207],[1661,1253],[434,1253]],"region":{"top_left_x":433,"top_left_y":1207,"width":1228,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25b8372077e24665a3f15f9d3dc645ad","type":"text","conversion_output":true,"text":"magnetic resonance imaging (MRI) of the brain. Non-contrast CT or MRI will be","text_display":" magnetic resonance imaging (MRI) of the brain. Non-contrast CT or MRI will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1259],[1682,1259],[1682,1304],[434,1304]],"region":{"top_left_x":433,"top_left_y":1258,"width":1250,"height":47},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02adfb10a6324d57afb08ff07723242d","type":"text","conversion_output":true,"text":"performed at baseline to ensure that the patient does not have evidence of acute","text_display":" performed at baseline to ensure that the patient does not have evidence of acute","confidence":1,"confidence_rate":1},{"cnt":[[434,1311],[1429,1311],[1429,1356],[434,1356]],"region":{"top_left_x":433,"top_left_y":1310,"width":996,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a42ac45414024786985575dac6ad1fc0","type":"text","conversion_output":true,"text":"intracranial hemorrhage (ICH) prior to study drug administration.","text_display":" intracranial hemorrhage (ICH) prior to study drug administration.","confidence":0.99951171875,"confidence_rate":0.9999930228743673},{"cnt":[[432,1403],[1699,1403],[1699,1450],[432,1450]],"region":{"top_left_x":431,"top_left_y":1402,"width":1269,"height":49},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48867219479e4c429c3955b449096cc8","type":"text","conversion_output":true,"text":"An additional non-contrast CT or MRI will be performed at 22 to 36 hours from the","text_display":"\n\nAn additional non-contrast CT or MRI will be performed at 22 to 36 hours from the","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,1454],[1712,1454],[1712,1502],[434,1502]],"region":{"top_left_x":433,"top_left_y":1454,"width":1280,"height":48},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9760475288fc4e35873fc8abf64d6587","type":"text","conversion_output":true,"text":"initiation (bolus) of study drug infusion. The purpose of this is to evaluate for ICH in","text_display":" initiation (bolus) of study drug infusion. The purpose of this is to evaluate for ICH in","confidence":1,"confidence_rate":1},{"cnt":[[434,1508],[1605,1508],[1605,1553],[434,1553]],"region":{"top_left_x":433,"top_left_y":1508,"width":1172,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2b14a0c69184708878ac15d90654af9","type":"text","conversion_output":true,"text":"the patient. Additional CT scans or MRIs should be performed based on the","text_display":" the patient. Additional CT scans or MRIs should be performed based on the","confidence":1,"confidence_rate":1},{"cnt":[[434,1560],[1399,1560],[1399,1605],[434,1605]],"region":{"top_left_x":433,"top_left_y":1559,"width":966,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f9721bb7eaed4d84b4782b45e9d4342b","type":"text","conversion_output":true,"text":"investigator's discretion, or if any clinical findings suggest ICH.","text_display":" investigator's discretion, or if any clinical findings suggest ICH.","confidence":0.99951171875,"confidence_rate":0.9999932166827553},{"cnt":[[434,1652],[1708,1652],[1708,1697],[434,1697]],"region":{"top_left_x":433,"top_left_y":1652,"width":1276,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b182edab9a144a3e9d5d3eb3268987af","type":"text","conversion_output":true,"text":"All CT and MRI scans will be evaluated by a central team of radiologists blinded to","text_display":"\n\nAll CT and MRI scans will be evaluated by a central team of radiologists blinded to","confidence":1,"confidence_rate":1},{"cnt":[[434,1706],[1745,1706],[1745,1747],[434,1747]],"region":{"top_left_x":433,"top_left_y":1705,"width":1312,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76926f171b974be8ac5662c79facf8ea","type":"text","conversion_output":true,"text":"the clinical attributes of the case. Results from the evaluation of the CT or MRI scans","text_display":" the clinical attributes of the case. Results from the evaluation of the CT or MRI scans","confidence":1,"confidence_rate":1},{"cnt":[[434,1757],[1371,1757],[1371,1803],[434,1803]],"region":{"top_left_x":433,"top_left_y":1757,"width":938,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8dc3725ad3f74a45b96c4bf9c37bc930","type":"text","conversion_output":true,"text":"by both local and central readings will be listed, as available.","text_display":" by both local and central readings will be listed, as available.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1205,2333],[1205,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":773,"height":37},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7667a4df077644ef88bba6e03f7149a6","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4973e0cc04b747d8bbbb81507e1db0e0","type":"page_info","conversion_output":false,"text":"27/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"044fa5092b344d8ba450e6a1527a4bdf","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd9d2ddc386f4f62ab25c616bcdbe242","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9946386743121138,"confidence_rate":0.9999172995864799},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3e1cc9827ef4e3097d4406ac4fa5e59","type":"page_info","conversion_output":false,"text":"788/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-29","page":29,"lines":[{"cnt":[[430,440],[1055,440],[1055,492],[430,492]],"region":{"top_left_x":429,"top_left_y":440,"width":626,"height":52},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43d3db479c6a4606982493d50eda3526","type":"section_header","conversion_output":false,"children_ids":["b1893972f25841b5977543c1644f84fd"],"text":"","text_display":""},{"cnt":[[434,443],[1051,443],[1051,488],[434,488]],"region":{"top_left_x":433,"top_left_y":442,"width":618,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1893972f25841b5977543c1644f84fd","type":"text","conversion_output":true,"parent_id":"43d3db479c6a4606982493d50eda3526","text":"4.6.3.1 Intracranial Hemorrhage","text_display":"\n\n\\subsection*{4.6.3.1 Intracranial Hemorrhage}","confidence":1,"confidence_rate":1},{"cnt":[[434,507],[1618,507],[1618,548],[434,548]],"region":{"top_left_x":433,"top_left_y":507,"width":1185,"height":41},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf49c5ea5c09405ea94c95b57114b249","type":"text","conversion_output":true,"text":"Intracranial hemorrhage events (ICH) are identified by neuroimaging and are","text_display":"\n\nIntracranial hemorrhage events (ICH) are identified by neuroimaging and are","confidence":1,"confidence_rate":1},{"cnt":[[434,559],[1648,559],[1648,599],[434,599]],"region":{"top_left_x":433,"top_left_y":558,"width":1215,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c2a840ca6a04b97afc7e92a5451e161","type":"text","conversion_output":true,"text":"recorded as AEs using one of the terms specified in protocol Appendix 13. The","text_display":" recorded as AEs using one of the terms specified in protocol Appendix 13. The","confidence":1,"confidence_rate":1},{"cnt":[[434,610],[1674,610],[1674,651],[434,651]],"region":{"top_left_x":433,"top_left_y":610,"width":1241,"height":41},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2084e7a6964741b183f13a7f0f371f52","type":"text","conversion_output":true,"text":"images obtained within the first 36 hours after treatment are further evaluated by","text_display":" images obtained within the first 36 hours after treatment are further evaluated by","confidence":0.9990234375,"confidence_rate":0.9999891440628391},{"cnt":[[434,662],[1227,662],[1227,703],[434,703]],"region":{"top_left_x":433,"top_left_y":661,"width":794,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"115be480465b46559e49be78449a5125","type":"text","conversion_output":true,"text":"central reading, which may or may not confirm ICH.","text_display":" central reading, which may or may not confirm ICH.","confidence":1,"confidence_rate":1},{"cnt":[[434,756],[1665,756],[1665,797],[434,797]],"region":{"top_left_x":433,"top_left_y":756,"width":1233,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1bb456a59ce4e6c88eb6c147f4ecf16","type":"text","conversion_output":true,"text":"While ICH may be identified at any time during the study, the first 36 hours after","text_display":"\n\nWhile ICH may be identified at any time during the study, the first 36 hours after","confidence":1,"confidence_rate":1},{"cnt":[[434,808],[1712,808],[1712,849],[434,849]],"region":{"top_left_x":433,"top_left_y":807,"width":1280,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"337fa98cff934714b6f989ec5b6fd1b6","type":"text","conversion_output":true,"text":"treatment are the key time interval. If multiple scans indicate ICH within 36 hours, it","text_display":" treatment are the key time interval. If multiple scans indicate ICH within 36 hours, it","confidence":1,"confidence_rate":1},{"cnt":[[434,859],[1725,859],[1725,900],[434,900]],"region":{"top_left_x":433,"top_left_y":859,"width":1293,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45a91e9d96014c9fb945410cc5231887","type":"text","conversion_output":true,"text":"is interpreted as a single ICH event. ICH events identified after the first 36 hours will","text_display":" is interpreted as a single ICH event. ICH events identified after the first 36 hours will","confidence":1,"confidence_rate":1},{"cnt":[[434,911],[1729,909],[1730,952],[434,954]],"region":{"top_left_x":433,"top_left_y":908,"width":1297,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a26d06547a545a5b09f22a864d7d053","type":"text","conversion_output":true,"text":"contribute to the general AE summaries. Timing of ICH will be determined according","text_display":" contribute to the general AE summaries. Timing of ICH will be determined according","confidence":1,"confidence_rate":1},{"cnt":[[434,962],[990,962],[990,1003],[434,1003]],"region":{"top_left_x":433,"top_left_y":962,"width":558,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60363f781a2d4f109371948966d47c4b","type":"text","conversion_output":true,"text":"to the rules specified in Appendix D.","text_display":" to the rules specified in Appendix D.","confidence":1,"confidence_rate":1},{"cnt":[[434,1057],[1663,1057],[1663,1098],[434,1098]],"region":{"top_left_x":433,"top_left_y":1057,"width":1230,"height":41},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b161be37775c466b90265dcaa14a9302","type":"text","conversion_output":true,"text":"Incidence of ICH within 36 hours by AE reporting will be presented by treatment","text_display":"\n\nIncidence of ICH within 36 hours by AE reporting will be presented by treatment","confidence":1,"confidence_rate":1},{"cnt":[[434,1109],[1738,1109],[1738,1149],[434,1149]],"region":{"top_left_x":433,"top_left_y":1108,"width":1306,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4d534f85ea444ecb833918b190d7060","type":"text","conversion_output":true,"text":"group. Determination of ICH within 36 hours from local and central readings of scans","text_display":" group. Determination of ICH within 36 hours from local and central readings of scans","confidence":0.9990234375,"confidence_rate":0.9999893800602199},{"cnt":[[434,1160],[1738,1160],[1738,1201],[434,1201]],"region":{"top_left_x":433,"top_left_y":1160,"width":1306,"height":41},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15511c8c916c451e92d4358a528da185","type":"text","conversion_output":true,"text":"will also be presented, and agreement between the local and central readings will be","text_display":" will also be presented, and agreement between the local and central readings will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1212],[591,1212],[591,1248],[434,1248]],"region":{"top_left_x":433,"top_left_y":1211,"width":158,"height":38},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7a38b510fb942d59d341e820623d035","type":"text","conversion_output":true,"text":"tabulated.","text_display":" tabulated.","confidence":1,"confidence_rate":1},{"cnt":[[434,1304],[1712,1304],[1712,1347],[434,1347]],"region":{"top_left_x":433,"top_left_y":1304,"width":1280,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"328e95c0c3544708b52f29c6d7578030","type":"text","conversion_output":true,"text":"Difference in percentage of subjects with ICH within 36 hours based on central and","text_display":"\n\nDifference in percentage of subjects with ICH within 36 hours based on central and","confidence":1,"confidence_rate":1},{"cnt":[[434,1354],[1708,1354],[1708,1399],[434,1399]],"region":{"top_left_x":433,"top_left_y":1353,"width":1276,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb6f930e85b348e4a836cd9b097ea463","type":"text","conversion_output":true,"text":"local scan reading will be reported by treatment group. A two-sided \\(95 \\% Cl\\) around","text_display":" local scan reading will be reported by treatment group. A two-sided \\(95 \\% Cl\\) around","confidence":0.9985356330871582,"confidence_rate":0.9999838963917971},{"cnt":[[434,1409],[1714,1409],[1714,1450],[434,1450]],"region":{"top_left_x":433,"top_left_y":1409,"width":1282,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f23d621763345feb5a2ae3c39d83a09","type":"text","conversion_output":true,"text":"this difference will be constructed using the Miettinen-Nurminen score method (20).","text_display":" this difference will be constructed using the Miettinen-Nurminen score method (20).","confidence":1,"confidence_rate":1},{"cnt":[[434,1502],[1721,1502],[1721,1545],[434,1545]],"region":{"top_left_x":433,"top_left_y":1501,"width":1288,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c64f01c5ddc843ca8520d78cd01a2455","type":"text","conversion_output":true,"text":"Additionally, central reading classifications will be used to further describe subtypes","text_display":"\n\nAdditionally, central reading classifications will be used to further describe subtypes","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,1551],[612,1551],[612,1594],[434,1594]],"region":{"top_left_x":433,"top_left_y":1551,"width":180,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"740c73c703c343cb840f8b846a88ba16","type":"text","conversion_output":true,"text":"of any ICH.","text_display":" of any ICH.","confidence":1,"confidence_rate":1},{"cnt":[[434,1646],[1613,1646],[1613,1687],[434,1687]],"region":{"top_left_x":433,"top_left_y":1645,"width":1181,"height":42},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c3cc1904be44199aa742ffa15b457a2","type":"text","conversion_output":true,"text":"The central reading will classify ICH according to the following intracerebreal","text_display":"\n\nThe central reading will classify ICH according to the following intracerebreal","confidence":1,"confidence_rate":1},{"cnt":[[434,1697],[587,1697],[587,1738],[434,1738]],"region":{"top_left_x":433,"top_left_y":1697,"width":154,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"107e7f8617bc4669a84337a6775711f2","type":"text","conversion_output":true,"text":"subtypes:","text_display":" subtypes:","confidence":1,"confidence_rate":1},{"cnt":[[434,1783],[1046,1783],[1046,1824],[434,1824]],"region":{"top_left_x":433,"top_left_y":1783,"width":614,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3fe94a426ff4c2280e2dfda1060a9a5","type":"text","conversion_output":true,"text":"- Hemorrhagic infarct type 1 or type 2","text_display":"\n- Hemorrhagic infarct type 1 or type 2","confidence":1,"confidence_rate":1},{"cnt":[[434,1848],[1119,1848],[1119,1888],[434,1888]],"region":{"top_left_x":433,"top_left_y":1847,"width":687,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29fb599236ef491892cf977469c317ee","type":"text","conversion_output":true,"text":"- Parenchymal hematoma type 1 or type 2","text_display":"\n- Parenchymal hematoma type 1 or type 2","confidence":1,"confidence_rate":1},{"cnt":[[434,1912],[1336,1912],[1336,1953],[434,1953]],"region":{"top_left_x":433,"top_left_y":1912,"width":904,"height":41},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8191f911ad45482c915d3753ba9c25ac","type":"text","conversion_output":true,"text":"- Remote intraparenchymal hemorrhage type 1 or type 2","text_display":"\n- Remote intraparenchymal hemorrhage type 1 or type 2","confidence":1,"confidence_rate":1},{"cnt":[[434,1981],[1558,1981],[1558,2022],[434,2022]],"region":{"top_left_x":433,"top_left_y":1980,"width":1125,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"612bb8a02adb45c499b701bc1a4f73a4","type":"text","conversion_output":true,"text":"In addition, subarachnoid hemorrhage, subdural hemorrhage, or epidural","text_display":"\n\nIn addition, subarachnoid hemorrhage, subdural hemorrhage, or epidural","confidence":1,"confidence_rate":1},{"cnt":[[434,2032],[1626,2032],[1626,2073],[434,2073]],"region":{"top_left_x":433,"top_left_y":2032,"width":1194,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da241c8749914b199f45e11f0e9fdf9c","type":"text","conversion_output":true,"text":"hemorrhage will be noted. ICH subtypes will be tabulated by treatment group.","text_display":" hemorrhage will be noted. ICH subtypes will be tabulated by treatment group.","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[430,2118],[1280,2118],[1280,2168],[430,2168]],"region":{"top_left_x":429,"top_left_y":2118,"width":852,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f30dcf8165cb4e8fad2c8d70e97344ed","type":"section_header","conversion_output":false,"children_ids":["825f7b5bf87a4d97ab11eb1e429d7f1d"],"text":"","text_display":""},{"cnt":[[434,2123],[1276,2123],[1276,2163],[434,2163]],"region":{"top_left_x":433,"top_left_y":2122,"width":844,"height":42},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"825f7b5bf87a4d97ab11eb1e429d7f1d","type":"text","conversion_output":true,"parent_id":"f30dcf8165cb4e8fad2c8d70e97344ed","text":"4.6.3.2 Symptomatic Intracranial Hemorrhage","text_display":"\n\n\\subsection*{4.6.3.2 Symptomatic Intracranial Hemorrhage}","confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[434,2183],[1725,2183],[1725,2224],[434,2224]],"region":{"top_left_x":433,"top_left_y":2182,"width":1293,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3276287caa2c4342bcb1b9d47349ebdd","type":"text","conversion_output":true,"text":"The protocol specifies that ICH is considered symptomatic (sICH) if it is not seen on","text_display":"\n\nThe protocol specifies that ICH is considered symptomatic (sICH) if it is not seen on","confidence":0.9603328704833984,"confidence_rate":0.9995503753944096},{"cnt":[[434,2237],[1734,2237],[1734,2277],[434,2277]],"region":{"top_left_x":433,"top_left_y":2236,"width":1301,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e95ad53ea8824e6992b67ab9d1dfd985","type":"text","conversion_output":true,"text":"CT or MRI scan at baseline, and any neurologic decline is attributed to it by the local","text_display":" CT or MRI scan at baseline, and any neurologic decline is attributed to it by the local","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8676115c5b44d6591ab0ce4de9b2849","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1182,2368],[1182,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":749,"height":33},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e6725e1740c4e4ab9c6fb706afdaa47","type":"page_info","conversion_output":false,"text":"28/ML29093 5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9bb86af62011440d9c329cc6017fda75","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9926941216741625,"confidence_rate":0.9998871956404722},{"cnt":[[372,2608],[694,2608],[694,2643],[372,2643]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":35},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90b63106b9684e3383903c90d53925f1","type":"page_info","conversion_output":false,"text":"789/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-30","page":30,"lines":[{"cnt":[[434,449],[1661,449],[1661,492],[434,492]],"region":{"top_left_x":433,"top_left_y":449,"width":1228,"height":43},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c1ac57698be45a38f228f6e3f913baa","type":"text","conversion_output":true,"text":"investigator. Both serious sICH and non-serious sICH events are required to be","text_display":"\ninvestigator. Both serious sICH and non-serious sICH events are required to be","confidence":1,"confidence_rate":1},{"cnt":[[434,501],[1300,501],[1300,544],[434,544]],"region":{"top_left_x":433,"top_left_y":500,"width":867,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fa74473395b461787085ca1f1e914ba","type":"text","conversion_output":true,"text":"reported by the investigator to the Sponsor immediately.","text_display":" reported by the investigator to the Sponsor immediately.","confidence":1,"confidence_rate":1},{"cnt":[[434,593],[1674,593],[1674,638],[434,638]],"region":{"top_left_x":433,"top_left_y":592,"width":1241,"height":47},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06b7549c85b946749f5a4426d954e7a0","type":"text","conversion_output":true,"text":"sICH within 36 hours is considered the primary safety outcome. sICH events are","text_display":"\nsICH within 36 hours is considered the primary safety outcome. sICH events are","confidence":0.9985356330871582,"confidence_rate":0.9999829601434831},{"cnt":[[434,645],[915,645],[915,690],[434,690]],"region":{"top_left_x":433,"top_left_y":644,"width":483,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecac162d5de44cb394bff01143f24449","type":"text","conversion_output":true,"text":"captured through AE reporting.","text_display":" captured through AE reporting.","confidence":1,"confidence_rate":1},{"cnt":[[434,735],[1721,735],[1721,780],[434,780]],"region":{"top_left_x":433,"top_left_y":734,"width":1288,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce07a955da904c0b86741ef4261f1ac3","type":"text","conversion_output":true,"text":"In addition to the primary definition of sICH, the following two definitions of sICH will","text_display":"\n\nIn addition to the primary definition of sICH, the following two definitions of sICH will","confidence":0.9970703125,"confidence_rate":0.9999687878548241},{"cnt":[[434,786],[1029,786],[1029,831],[434,831]],"region":{"top_left_x":433,"top_left_y":786,"width":597,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22ed7a443c8f45319642a6111827f4a0","type":"text","conversion_output":true,"text":"be explored and reported in this study.","text_display":" be explored and reported in this study.","confidence":1,"confidence_rate":1},{"cnt":[[434,872],[1665,872],[1665,920],[434,920]],"region":{"top_left_x":433,"top_left_y":872,"width":1233,"height":48},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"161c2dc84c92410d94d3c80388f81c76","type":"text","conversion_output":true,"text":"- sICH using Heidelberg classification: either (1) PH2 as reported by radiology","text_display":"\n- sICH using Heidelberg classification: either (1) PH2 as reported by radiology","confidence":1,"confidence_rate":1},{"cnt":[[486,920],[1682,920],[1682,965],[486,965]],"region":{"top_left_x":485,"top_left_y":919,"width":1198,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d325a9e2a2184e20ac42a88c25cc01b4","type":"text","conversion_output":true,"text":"core, or (2) an sICH as classified by PRISMS but also associated with 4-point","text_display":" core, or (2) an sICH as classified by PRISMS but also associated with 4-point","confidence":1,"confidence_rate":1},{"cnt":[[486,962],[1665,962],[1665,1005],[486,1005]],"region":{"top_left_x":485,"top_left_y":962,"width":1181,"height":44},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1be7d06bb284f79a7d71ce9c5904ec0","type":"text","conversion_output":true,"text":"total NIHSS score worsening or 2 point worsening on any single NIHSS item","text_display":" total NIHSS score worsening or 2 point worsening on any single NIHSS item","confidence":1,"confidence_rate":1},{"cnt":[[486,1005],[1349,1005],[1349,1051],[486,1051]],"region":{"top_left_x":485,"top_left_y":1005,"width":865,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8cf38f6a03d4a19bbf39c05cd783d92","type":"text","conversion_output":true,"text":"when comparing scores immediately pre and post scan.","text_display":" when comparing scores immediately pre and post scan.","confidence":1,"confidence_rate":1},{"cnt":[[434,1068],[1687,1068],[1687,1113],[434,1113]],"region":{"top_left_x":433,"top_left_y":1067,"width":1254,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"391470ec64534389a091fc9b4318a609","type":"text","conversion_output":true,"text":"- sICH using SITS-MOST definition (25): PH2 as listed by radiology core on CT","text_display":"\n- sICH using SITS-MOST definition (25): PH2 as listed by radiology core on CT","confidence":1,"confidence_rate":1},{"cnt":[[486,1113],[1732,1113],[1732,1156],[486,1156]],"region":{"top_left_x":485,"top_left_y":1112,"width":1247,"height":44},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b502501bc00e49fdb25a89b1004db2dd","type":"text","conversion_output":true,"text":"scan between 22-36 hours, which is associated with deterioration of \\(\\geq 4\\) points on","text_display":" scan between 22-36 hours, which is associated with deterioration of \\(\\geq 4\\) points on","confidence":0.6720349788665771,"confidence_rate":0.9954937645030691},{"cnt":[[486,1156],[1674,1156],[1674,1197],[486,1197]],"region":{"top_left_x":485,"top_left_y":1155,"width":1189,"height":42},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f73b57a9fed405a85414fc5b8763b3f","type":"text","conversion_output":true,"text":"the NIHSS from the lowest NIHSS value between baseline and 36 hours, but","text_display":" the NIHSS from the lowest NIHSS value between baseline and 36 hours, but","confidence":1,"confidence_rate":1},{"cnt":[[486,1199],[1081,1199],[1081,1244],[486,1244]],"region":{"top_left_x":485,"top_left_y":1198,"width":596,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea8f02bbc21d4e8f9826f57f34096147","type":"text","conversion_output":true,"text":"prior to repeat CT, or leading to death.","text_display":" prior to repeat CT, or leading to death.","confidence":0.99853515625,"confidence_rate":0.9999674245820905},{"cnt":[[434,1268],[1601,1268],[1601,1313],[434,1313]],"region":{"top_left_x":433,"top_left_y":1267,"width":1168,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91ca86930f4d44f69e209c38bae40ccc","type":"text","conversion_output":true,"text":"Percentage of subjects with sICH within 36 hours will be presented for each","text_display":"\n\nPercentage of subjects with sICH within 36 hours will be presented for each","confidence":1,"confidence_rate":1},{"cnt":[[434,1319],[1712,1319],[1712,1364],[434,1364]],"region":{"top_left_x":433,"top_left_y":1319,"width":1280,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"390407d299584b6b962ac2a46e013ca4","type":"text","conversion_output":true,"text":"definition by treatment group. Difference between treatment group percentages will","text_display":" definition by treatment group. Difference between treatment group percentages will","confidence":1,"confidence_rate":1},{"cnt":[[434,1371],[1598,1371],[1598,1416],[434,1416]],"region":{"top_left_x":433,"top_left_y":1370,"width":1166,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b6fe610ede84b60b6884bdeb91d9323","type":"text","conversion_output":true,"text":"be reported along with a two-sided \\(95 \\% Cl\\) constructed using the Miettinen-","text_display":" be reported along with a two-sided \\(95 \\% Cl\\) constructed using the Miettinen","confidence":0.9926862716674805,"confidence_rate":0.9999126156662286},{"cnt":[[434,1422],[892,1422],[892,1467],[434,1467]],"region":{"top_left_x":433,"top_left_y":1422,"width":459,"height":46},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"01eda9397dd044d2b7a41c3727797d45","type":"text","conversion_output":true,"text":"Nurminen score method (20).","text_display":"Nurminen score method (20).","confidence":1,"confidence_rate":1},{"cnt":[[434,1517],[1646,1517],[1646,1562],[434,1562]],"region":{"top_left_x":433,"top_left_y":1516,"width":1213,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ec0fb6e662a45629364a7c7cd1ce749","type":"text","conversion_output":true,"text":"ICH symptomatology will be tabulated for confirmed strokes and separately for","text_display":"\n\nICH symptomatology will be tabulated for confirmed strokes and separately for","confidence":1,"confidence_rate":1},{"cnt":[[434,1568],[662,1568],[662,1609],[434,1609]],"region":{"top_left_x":433,"top_left_y":1568,"width":229,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc247ab680d943ada06a7c10242e1149","type":"text","conversion_output":true,"text":"stroke mimics.","text_display":" stroke mimics.","confidence":1,"confidence_rate":1},{"cnt":[[301,1654],[711,1654],[711,1704],[301,1704]],"region":{"top_left_x":300,"top_left_y":1654,"width":412,"height":50},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12cf402a950d4d058d4e085690af69db","type":"section_header","conversion_output":false,"children_ids":["43fa71f9e4334525b6249fab15269eeb"],"text":"","text_display":""},{"cnt":[[305,1659],[707,1659],[707,1704],[305,1704]],"region":{"top_left_x":305,"top_left_y":1658,"width":402,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43fa71f9e4334525b6249fab15269eeb","type":"text","conversion_output":true,"parent_id":"12cf402a950d4d058d4e085690af69db","text":"4.6.4 Laboratory Data","text_display":"\n\n\\subsection*{4.6.4 Laboratory Data}","confidence":0.9990234375,"confidence_rate":0.9999624222580676},{"cnt":[[434,1725],[1669,1725],[1669,1772],[434,1772]],"region":{"top_left_x":433,"top_left_y":1725,"width":1237,"height":48},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70ce923e4c174cf49c857fd7c5b77ff7","type":"text","conversion_output":true,"text":"Specimens for the laboratory tests will be analyzed by the site's local laboratory.","text_display":"\n\nSpecimens for the laboratory tests will be analyzed by the site's local laboratory.","confidence":0.9990234375,"confidence_rate":0.9999888973383643},{"cnt":[[434,1779],[1682,1779],[1682,1824],[434,1824]],"region":{"top_left_x":433,"top_left_y":1778,"width":1250,"height":47},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5df11187de04e6bbb1f0c6c8b42fd6e","type":"text","conversion_output":true,"text":"Tests will be done at screening only and will include hematology (complete blood","text_display":" Tests will be done at screening only and will include hematology (complete blood","confidence":1,"confidence_rate":1},{"cnt":[[434,1830],[1575,1830],[1575,1876],[434,1876]],"region":{"top_left_x":433,"top_left_y":1830,"width":1142,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23636b26f54a4c6e97f0e4c8adeb0013","type":"text","conversion_output":true,"text":"count without differential), serum glucose, coagulation values (INR, partial","text_display":" count without differential), serum glucose, coagulation values (INR, partial","confidence":1,"confidence_rate":1},{"cnt":[[434,1882],[1081,1882],[1081,1927],[434,1927]],"region":{"top_left_x":433,"top_left_y":1882,"width":648,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7656d1c16faf41489cd45372fb051dcf","type":"text","conversion_output":true,"text":"thromboplastin time), and pregnancy test.","text_display":" thromboplastin time), and pregnancy test.","confidence":1,"confidence_rate":1},{"cnt":[[434,1972],[1661,1972],[1661,2017],[434,2017]],"region":{"top_left_x":433,"top_left_y":1972,"width":1228,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af5cfb55df744bd8acf072993978c227","type":"text","conversion_output":true,"text":"Lab results will be converted to SI units and summarized as part of the baseline","text_display":"\n\nLab results will be converted to SI units and summarized as part of the baseline","confidence":0.9990234375,"confidence_rate":0.9999885054819704},{"cnt":[[434,2024],[1618,2024],[1618,2071],[434,2071]],"region":{"top_left_x":433,"top_left_y":2023,"width":1185,"height":49},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee390ffc59464e7684e8d4a95bdbfcd5","type":"text","conversion_output":true,"text":"treatment group comparability described in Section 4.3; no further analysis is","text_display":" treatment group comparability described in Section 4.3; no further analysis is","confidence":1,"confidence_rate":1},{"cnt":[[434,2075],[574,2075],[574,2125],[434,2125]],"region":{"top_left_x":433,"top_left_y":2075,"width":141,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4ba581fb87e4c4a9eba13d386a29702","type":"text","conversion_output":true,"text":"planned.","text_display":" planned.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b03068572084198987a2aeb968b0cc6","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec8077acf0704fc6bbb6f5a7ef8d3bf4","type":"page_info","conversion_output":false,"text":"29/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a287841aef446e8a1b579f130866ad6","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e65e20e231bb4d38af9afb27be019ff6","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9941506325279192,"confidence_rate":0.9999097495800716},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"536c1a2cc5594cd68912ecfbff5c3115","type":"page_info","conversion_output":false,"text":"790/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-31","page":31,"lines":[{"cnt":[[296,438],[625,438],[625,492],[296,492]],"region":{"top_left_x":296,"top_left_y":438,"width":330,"height":54},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7644bbb264f64dddb7e5314d5c66f90c","type":"section_header","conversion_output":false,"children_ids":["7fe0fbf339104aafad6ad1c509e7c80b"],"text":"","text_display":""},{"cnt":[[301,443],[621,443],[621,488],[301,488]],"region":{"top_left_x":300,"top_left_y":442,"width":321,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7fe0fbf339104aafad6ad1c509e7c80b","type":"text","conversion_output":true,"parent_id":"7644bbb264f64dddb7e5314d5c66f90c","text":"4.6.5 Vital Signs","text_display":"\n\n\\subsection*{4.6.5 Vital Signs}","confidence":1,"confidence_rate":1},{"cnt":[[432,511],[1678,511],[1678,556],[432,556]],"region":{"top_left_x":431,"top_left_y":511,"width":1247,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a43756d745a42929f79b838508531c7","type":"text","conversion_output":true,"text":"Vital signs will be collected at screening, and will include measurements of pulse","text_display":"\n\nVital signs will be collected at screening, and will include measurements of pulse","confidence":1,"confidence_rate":1},{"cnt":[[432,561],[1575,561],[1575,608],[432,608]],"region":{"top_left_x":431,"top_left_y":560,"width":1144,"height":49},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10b8a1c163b34c2f9f29eb04d5045264","type":"text","conversion_output":true,"text":"and systolic/diastolic blood pressure (while patient is in a supine position).","text_display":" and systolic/diastolic blood pressure (while patient is in a supine position).","confidence":0.9980480668600649,"confidence_rate":0.9999764600283461},{"cnt":[[432,653],[1727,653],[1727,703],[432,703]],"region":{"top_left_x":431,"top_left_y":653,"width":1297,"height":50},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83b861ef2c2a4194b89d1f17aacdd292","type":"text","conversion_output":true,"text":"Vital signs will be summarized as part of the baseline treatment group comparability","text_display":"\n\nVital signs will be summarized as part of the baseline treatment group comparability","confidence":1,"confidence_rate":1},{"cnt":[[432,705],[823,705],[823,750],[432,750]],"region":{"top_left_x":431,"top_left_y":704,"width":392,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b703033d5fc4955a9957e5cc5c11d8b","type":"text","conversion_output":true,"text":"described in Section 4.3.","text_display":" described in Section 4.3.","confidence":1,"confidence_rate":1},{"cnt":[[296,791],[593,791],[593,849],[296,849]],"region":{"top_left_x":296,"top_left_y":790,"width":297,"height":59},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e57c17c71c1463ebe91d4a7af3f5a4b","type":"section_header","conversion_output":false,"children_ids":["2a476c3e8b1541a5a9f62c7a62dc35ad"],"text":"","text_display":""},{"cnt":[[303,795],[587,795],[587,844],[303,844]],"region":{"top_left_x":302,"top_left_y":794,"width":285,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2a476c3e8b1541a5a9f62c7a62dc35ad","type":"text","conversion_output":true,"parent_id":"7e57c17c71c1463ebe91d4a7af3f5a4b","text":"4.6.6 Mortality","text_display":"\n\n\\subsection*{4.6.6 Mortality}","confidence":0.99951171875,"confidence_rate":0.9999755802732609},{"cnt":[[434,864],[1691,864],[1691,909],[434,909]],"region":{"top_left_x":433,"top_left_y":863,"width":1258,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47bf2c0816614889b3595aff1cc86033","type":"text","conversion_output":true,"text":"Incidence of mortality will be calculated by treatment group and overall. Details of","text_display":"\n\nIncidence of mortality will be calculated by treatment group and overall. Details of","confidence":1,"confidence_rate":1},{"cnt":[[434,915],[1489,915],[1489,960],[434,960]],"region":{"top_left_x":433,"top_left_y":915,"width":1056,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7445f7d0dca4707baf17731a0991d23","type":"text","conversion_output":true,"text":"any deaths will be presented in the form of individual patient listings.","text_display":" any deaths will be presented in the form of individual patient listings.","confidence":1,"confidence_rate":1},{"cnt":[[296,997],[1098,997],[1098,1051],[296,1051]],"region":{"top_left_x":296,"top_left_y":996,"width":802,"height":55},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fb5c84f9f07c441eb46208bd11dc1dda","type":"section_header","conversion_output":false,"children_ids":["3fef9c634db545edb8bb9d6e78dd0546"],"text":"","text_display":""},{"cnt":[[301,1001],[1094,1001],[1094,1046],[301,1046]],"region":{"top_left_x":300,"top_left_y":1001,"width":794,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fef9c634db545edb8bb9d6e78dd0546","type":"text","conversion_output":true,"parent_id":"fb5c84f9f07c441eb46208bd11dc1dda","text":"4.6.7 Previous and Concomitant Medications","text_display":"\n\n\\subsection*{4.6.7 Previous and Concomitant Medications}","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[434,1070],[1579,1070],[1579,1119],[434,1119]],"region":{"top_left_x":433,"top_left_y":1069,"width":1147,"height":51},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"445e2d8205c441d2a59811fae033e959","type":"text","conversion_output":true,"text":"Previous medications refer to those stopped prior to study day 1. Previous","text_display":"\n\nPrevious medications refer to those stopped prior to study day 1. Previous","confidence":0.90576171875,"confidence_rate":0.9987478856751976},{"cnt":[[434,1121],[1704,1121],[1704,1171],[434,1171]],"region":{"top_left_x":433,"top_left_y":1121,"width":1271,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a15a3186c8547c9b3aba79d9492e1bc","type":"text","conversion_output":true,"text":"medications will be summarized by medication class and preferred term. Usage of","text_display":" medications will be summarized by medication class and preferred term. Usage of","confidence":1,"confidence_rate":1},{"cnt":[[432,1173],[1691,1173],[1691,1222],[432,1222]],"region":{"top_left_x":431,"top_left_y":1173,"width":1260,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f9f6a19e0534d5086510ba416f82ce1","type":"text","conversion_output":true,"text":"Aspirin / antiplatelet drugs and Heparin / anticoagulant drugs up to 7 days prior to","text_display":" Aspirin / antiplatelet drugs and Heparin / anticoagulant drugs up to 7 days prior to","confidence":1,"confidence_rate":1},{"cnt":[[434,1225],[1106,1225],[1106,1274],[434,1274]],"region":{"top_left_x":433,"top_left_y":1224,"width":674,"height":51},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acf3e804f9af44ffa8100219f0d968ef","type":"text","conversion_output":true,"text":"screening/stroke onset will be summarized.","text_display":" screening/stroke onset will be summarized.","confidence":1,"confidence_rate":1},{"cnt":[[434,1319],[1652,1319],[1652,1369],[434,1369]],"region":{"top_left_x":433,"top_left_y":1319,"width":1220,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40abc2ec979d41338ef9e9b6a89d019f","type":"text","conversion_output":true,"text":"Concomitant medications refer to those ongoing during the study. Concomitant","text_display":"\n\nConcomitant medications refer to those ongoing during the study. Concomitant","confidence":1,"confidence_rate":1},{"cnt":[[434,1371],[1704,1371],[1704,1420],[434,1420]],"region":{"top_left_x":433,"top_left_y":1370,"width":1271,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"777df8e09644471eba4d1ecc44c5f7b9","type":"text","conversion_output":true,"text":"medications will be summarized by medication class and preferred term. Usage of","text_display":" medications will be summarized by medication class and preferred term. Usage of","confidence":1,"confidence_rate":1},{"cnt":[[434,1422],[1644,1422],[1644,1472],[434,1472]],"region":{"top_left_x":433,"top_left_y":1422,"width":1211,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3c1108aa58b24f7daa0a0d04ae274a46","type":"text","conversion_output":true,"text":"reperfusion therapy will be summarized. Reperfusion therapy includes IV or IA","text_display":" reperfusion therapy will be summarized. Reperfusion therapy includes IV or IA","confidence":1,"confidence_rate":1},{"cnt":[[434,1474],[1714,1474],[1714,1523],[434,1523]],"region":{"top_left_x":433,"top_left_y":1473,"width":1282,"height":51},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3856b107e75e431993f568e90baaabd3","type":"text","conversion_output":true,"text":"alteplase and/or endovascular therapy, and will be adjudicated in a medical review.","text_display":" alteplase and/or endovascular therapy, and will be adjudicated in a medical review.","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[327,1558],[1661,1558],[1661,1618],[327,1618]],"region":{"top_left_x":326,"top_left_y":1557,"width":1335,"height":61},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57301f5dd7834b1bbbc561fbb26c8cbf","type":"section_header","conversion_output":false,"children_ids":["054c998a210645b1a736988faf5b82f6"],"text":"","text_display":""},{"cnt":[[331,1564],[1656,1564],[1656,1611],[331,1611]],"region":{"top_left_x":330,"top_left_y":1564,"width":1327,"height":48},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"054c998a210645b1a736988faf5b82f6","type":"text","conversion_output":true,"parent_id":"57301f5dd7834b1bbbc561fbb26c8cbf","text":"4.7 HANDLING OF DROPOUTS, MISSING/INCOMPLETE DATA, OR OUTLIERS","text_display":"\n\n\\subsection*{4.7 HANDLING OF DROPOUTS, MISSING/INCOMPLETE DATA, OR OUTLIERS}","confidence":1,"confidence_rate":1},{"cnt":[[434,1633],[1708,1633],[1708,1678],[434,1678]],"region":{"top_left_x":433,"top_left_y":1632,"width":1276,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5303304f6b9747dbb6abe21e1c70c31d","type":"text","conversion_output":true,"text":"For the analyses of the mRS based endpoints, last observation carried forward will","text_display":"\n\nFor the analyses of the mRS based endpoints, last observation carried forward will","confidence":0.84375,"confidence_rate":0.9981747963503771},{"cnt":[[434,1684],[1687,1684],[1687,1732],[434,1732]],"region":{"top_left_x":433,"top_left_y":1684,"width":1254,"height":48},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b91dec823ad0401a9c7b442cced9d702","type":"text","conversion_output":true,"text":"be used to impute missing or out of window assessments of mRS at Day 90. The","text_display":" be used to impute missing or out of window assessments of mRS at Day 90. The","confidence":0.8907484664814547,"confidence_rate":0.9986710769495858},{"cnt":[[434,1736],[1579,1736],[1579,1783],[434,1783]],"region":{"top_left_x":433,"top_left_y":1735,"width":1147,"height":49},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc83c672d2ca499798ba6919886c631a","type":"text","conversion_output":true,"text":"mRS result carried forward needs to be on or after Day 4 to qualify for this","text_display":" mRS result carried forward needs to be on or after Day 4 to qualify for this","confidence":1,"confidence_rate":1},{"cnt":[[434,1788],[1742,1788],[1742,1837],[434,1837]],"region":{"top_left_x":433,"top_left_y":1787,"width":1310,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1b67af33aa54a8088064bec120d7425","type":"text","conversion_output":true,"text":"imputation. If there is no in-window or LOCF assessment of mRS , then a late Day 90","text_display":" imputation. If there is no in-window or LOCF assessment of mRS , then a late Day 90","confidence":0.96728515625,"confidence_rate":0.9996424086879994},{"cnt":[[434,1839],[896,1839],[896,1884],[434,1884]],"region":{"top_left_x":433,"top_left_y":1839,"width":463,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be34d3f10e05475e9a57670755a21f61","type":"text","conversion_output":true,"text":"mRS will be used if available.","text_display":" mRS will be used if available.","confidence":1,"confidence_rate":1},{"cnt":[[434,1934],[1648,1934],[1648,1979],[434,1979]],"region":{"top_left_x":433,"top_left_y":1933,"width":1215,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"131cabe137c84d41879afeba8b9b246c","type":"text","conversion_output":true,"text":"ITT patients without any observed mRS past day 4 will have their Day 90 mRS","text_display":"\n\nITT patients without any observed mRS past day 4 will have their Day 90 mRS","confidence":0.994140625,"confidence_rate":0.9999347064818369},{"cnt":[[434,1985],[1682,1985],[1682,2035],[434,2035]],"region":{"top_left_x":433,"top_left_y":1985,"width":1250,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9f4121029f64561b9b12dfd306d9f18","type":"text","conversion_output":true,"text":"simulated by a hot deck method. This will be an adjustment cells imputation (24),","text_display":" simulated by a hot deck method. This will be an adjustment cells imputation (24),","confidence":1,"confidence_rate":1},{"cnt":[[434,2037],[1721,2037],[1721,2086],[434,2086]],"region":{"top_left_x":433,"top_left_y":2036,"width":1288,"height":51},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"baa69cef95c845afb4d2351063ef79ba","type":"text","conversion_output":true,"text":"with the cells defined by treatment group, age (< 65 vs. \\(\\geq 65\\) ), pre-treatment NIHSS","text_display":" with the cells defined by treatment group, age (< 65 vs. \\(\\geq 65\\) ), pre-treatment NIHSS","confidence":0.6980919409543276,"confidence_rate":0.9961838483366479},{"cnt":[[434,2088],[1682,2088],[1682,2138],[434,2138]],"region":{"top_left_x":433,"top_left_y":2088,"width":1250,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"661d54121b2341f5b1f5f1382790abc4","type":"text","conversion_output":true,"text":"score ( \\(0-2\\) vs. \\(3-5\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(>2\\)","text_display":" score ( \\(0-2\\) vs. \\(3-5\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(>2\\)","confidence":0.517710645082192,"confidence_rate":0.9928696857331074},{"cnt":[[434,2140],[1747,2140],[1747,2189],[434,2189]],"region":{"top_left_x":433,"top_left_y":2139,"width":1314,"height":51},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6118646e199f459eb4891d0f5b33c652","type":"text","conversion_output":true,"text":"hours). For each patient with a missing mRS score, a \"donor\" patient will be drawn at","text_display":" hours). For each patient with a missing mRS score, a \"donor\" patient will be drawn at","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[434,2191],[1695,2191],[1695,2241],[434,2241]],"region":{"top_left_x":433,"top_left_y":2191,"width":1263,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1968a1ce231844fc996aec20c5ff639d","type":"text","conversion_output":true,"text":"random from the pool of patients with available mRS and who belong to the same","text_display":" random from the pool of patients with available mRS and who belong to the same","confidence":1,"confidence_rate":1},{"cnt":[[434,2243],[1695,2243],[1695,2292],[434,2292]],"region":{"top_left_x":433,"top_left_y":2242,"width":1263,"height":51},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca04cf267091474681bd7aed94b210bf","type":"text","conversion_output":true,"text":"cell as the recepient (i.e. randomized to the same treatment group and having the","text_display":" cell as the recepient (i.e. randomized to the same treatment group and having the","confidence":1,"confidence_rate":1},{"cnt":[[434,2331],[1205,2331],[1205,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2331,"width":773,"height":39},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e134168d94b480c8b56e15f29b09a72","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":38},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d0d925353c240628e8416d9261eb45a","type":"text","conversion_output":true,"text":"30/ML29093","text_display":"\n30/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2404],[1044,2404]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7723d54cd608419e9375f2a8071cd31c","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"986b752add8b497a9d364bb5d9042315","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9926893626123956,"confidence_rate":0.9998871218934369},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d761dca611849b58dc9cdaa3be830e4","type":"page_info","conversion_output":false,"text":"791/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-32","page":32,"lines":[{"cnt":[[434,447],[1678,447],[1678,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":1245,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d1179a44f764f6ebb91d10337fa45ae","type":"text","conversion_output":true,"text":"same categories for age, last known well time to treatment and baseline NIHSS).","text_display":"\nsame categories for age, last known well time to treatment and baseline NIHSS).","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[1369,498],[1369,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":936,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce68984b5cbd4696a9fe5c17e1becf1e","type":"text","conversion_output":true,"text":"The imputed mRS will then be the mRS value of the \"donor\".","text_display":" The imputed mRS will then be the mRS value of the \"donor\".","confidence":0.9990234375,"confidence_rate":0.9999869728895492},{"cnt":[[434,593],[1727,593],[1727,638],[434,638]],"region":{"top_left_x":433,"top_left_y":592,"width":1295,"height":47},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc0594376e6d4125a9a4bc41c0c24646","type":"text","conversion_output":true,"text":"It is expected that only a small number of patients will need the hot deck imputation;","text_display":"\n\nIt is expected that only a small number of patients will need the hot deck imputation;","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[434,645],[1596,645],[1596,690],[434,690]],"region":{"top_left_x":433,"top_left_y":644,"width":1164,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7a26b9653a948c49781c632935de6a4","type":"text","conversion_output":true,"text":"therefore, the techniques recommended in (24) for a variance estimate that","text_display":" therefore, the techniques recommended in (24) for a variance estimate that","confidence":1,"confidence_rate":1},{"cnt":[[434,696],[1601,696],[1601,741],[434,741]],"region":{"top_left_x":433,"top_left_y":696,"width":1168,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75a9d34c834c4b7d878472b17e0d2a6e","type":"text","conversion_output":true,"text":"incorporates the additional variance from the missing information will not be","text_display":" incorporates the additional variance from the missing information will not be","confidence":1,"confidence_rate":1},{"cnt":[[434,748],[649,748],[649,793],[434,793]],"region":{"top_left_x":433,"top_left_y":747,"width":216,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26331f48ec404f1692cb6a4c5aa8e4d2","type":"text","conversion_output":true,"text":"implemented.","text_display":" implemented.","confidence":1,"confidence_rate":1},{"cnt":[[434,838],[1712,838],[1712,885],[434,885]],"region":{"top_left_x":433,"top_left_y":837,"width":1280,"height":49},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23ed827fcd0e49179ecbfa4c6636660a","type":"text","conversion_output":true,"text":"No imputation of missing patient reported outcomes, cognitive assessments, or the","text_display":"\n\nNo imputation of missing patient reported outcomes, cognitive assessments, or the","confidence":1,"confidence_rate":1},{"cnt":[[434,889],[1712,889],[1712,937],[434,937]],"region":{"top_left_x":433,"top_left_y":889,"width":1280,"height":48},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08fac75aecac4d41a222d2618eb48029","type":"text","conversion_output":true,"text":"10 -meter walk test will be performed except as specified in the scoring rules for the","text_display":" 10 -meter walk test will be performed except as specified in the scoring rules for the","confidence":0.4811697006225586,"confidence_rate":0.9919047746606292},{"cnt":[[434,945],[1712,945],[1712,990],[434,990]],"region":{"top_left_x":433,"top_left_y":945,"width":1280,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2dc0a1d289942f39347b7166d837575","type":"text","conversion_output":true,"text":"assessment. Reasons for the assessment not being performed will be summarized","text_display":" assessment. Reasons for the assessment not being performed will be summarized","confidence":1,"confidence_rate":1},{"cnt":[[434,997],[1489,997],[1489,1042],[434,1042]],"region":{"top_left_x":433,"top_left_y":996,"width":1056,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c9f432f3e2b84136ab379d70fd22ffad","type":"text","conversion_output":true,"text":"by the number and percentage in each category by treatment group.","text_display":" by the number and percentage in each category by treatment group.","confidence":1,"confidence_rate":1},{"cnt":[[327,1079],[1250,1079],[1250,1130],[327,1130]],"region":{"top_left_x":326,"top_left_y":1078,"width":925,"height":53},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"910568d01ebd42e4bde0079f79348fd0","type":"section_header","conversion_output":false,"children_ids":["cf6b50a6df104c4b9e6cbb8a27b98922"],"text":"","text_display":""},{"cnt":[[331,1085],[1244,1085],[1244,1124],[331,1124]],"region":{"top_left_x":330,"top_left_y":1084,"width":914,"height":40},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf6b50a6df104c4b9e6cbb8a27b98922","type":"text","conversion_output":true,"parent_id":"910568d01ebd42e4bde0079f79348fd0","text":"4.8 INTERIM ANALYSES AND/OR SAFETY REVIEWS","text_display":"\n\n\\subsection*{4.8 INTERIM ANALYSES AND/OR SAFETY REVIEWS}","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[434,1154],[1689,1154],[1689,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1153,"width":1256,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3eba1e21455c4c778a6d89c7b6cdd770","type":"text","conversion_output":true,"text":"One interim analysis of the primary efficacy outcome was planned for clear futility","text_display":"\n\nOne interim analysis of the primary efficacy outcome was planned for clear futility","confidence":1,"confidence_rate":1},{"cnt":[[434,1205],[1723,1205],[1723,1250],[434,1250]],"region":{"top_left_x":433,"top_left_y":1205,"width":1291,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4b99437ca6d4371af04fa8cd307bdec","type":"text","conversion_output":true,"text":"after approximately \\(50 \\%\\) of patients have completed or discontinued from the study,","text_display":" after approximately \\(50 \\%\\) of patients have completed or discontinued from the study,","confidence":0.9931640625,"confidence_rate":0.9999237872426632},{"cnt":[[434,1257],[1738,1257],[1738,1302],[434,1302]],"region":{"top_left_x":433,"top_left_y":1256,"width":1306,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2bcaaf5fd4b048adb21ddd151870fe76","type":"text","conversion_output":true,"text":"but this analysis was not performed due to early termination of the study. In addition,","text_display":" but this analysis was not performed due to early termination of the study. In addition,","confidence":1,"confidence_rate":1},{"cnt":[[434,1309],[1714,1307],[1715,1354],[434,1356]],"region":{"top_left_x":433,"top_left_y":1306,"width":1282,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ff27f01c7e48424c8dc86f087eeef88f","type":"text","conversion_output":true,"text":"there were 4 planned safety reviews, of which two have occured after \\(5 \\%(50)\\), and","text_display":" there were 4 planned safety reviews, of which two have occured after \\(5 \\%(50)\\), and","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[434,1362],[1085,1362],[1085,1405],[434,1405]],"region":{"top_left_x":433,"top_left_y":1362,"width":652,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f6361656f684f27ae869f026394d9f1","type":"text","conversion_output":true,"text":"\\(25 \\%(237)\\) of patients have been enrolled.","text_display":" \\(25 \\%(237)\\) of patients have been enrolled.","confidence":0.8716444969177246,"confidence_rate":0.9968827409269148},{"cnt":[[434,1454],[1704,1454],[1704,1497],[434,1497]],"region":{"top_left_x":433,"top_left_y":1454,"width":1271,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4656f8e5c20740b185e18d2b4d2f6d00","type":"text","conversion_output":true,"text":"Details on the procedures for the safety reviews and the interim analysis are in the","text_display":"\n\nDetails on the procedures for the safety reviews and the interim analysis are in the","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[434,1504],[771,1504],[771,1545],[434,1545]],"region":{"top_left_x":433,"top_left_y":1503,"width":339,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75396206f7c340b69bf2e5876947f0e6","type":"text","conversion_output":true,"text":"Charter for the iDMC.","text_display":" Charter for the iDMC.","confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[348,1590],[681,1590],[681,1635],[348,1635]],"region":{"top_left_x":348,"top_left_y":1589,"width":334,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76fe2c0e850d4bdf9212215ce04e1e91","type":"section_header","conversion_output":false,"children_ids":["9e1cc0937477488da6463bf03b5ccd47"],"text":"","text_display":""},{"cnt":[[352,1594],[677,1594],[677,1635],[352,1635]],"region":{"top_left_x":352,"top_left_y":1594,"width":325,"height":41},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e1cc0937477488da6463bf03b5ccd47","type":"text","conversion_output":true,"parent_id":"76fe2c0e850d4bdf9212215ce04e1e91","text":"5. REFERENCES","text_display":"\n\n\\section*{5. REFERENCES}","confidence":1,"confidence_rate":1},{"cnt":[[434,1654],[1648,1654],[1648,1695],[434,1695]],"region":{"top_left_x":433,"top_left_y":1654,"width":1215,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10d87bb892814d968b4aa47c5dc0f662","type":"text","conversion_output":true,"text":"1. Austin P. An Introduction to Propensity Score Methods for Reducing the Effects of","text_display":"\n1. Austin P. An Introduction to Propensity Score Methods for Reducing the Effects of","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[486,1695],[1712,1695],[1712,1738],[486,1738]],"region":{"top_left_x":485,"top_left_y":1695,"width":1228,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d86f87addd746ca8a78a671e9850001","type":"text","conversion_output":true,"text":"Confounding in Observational Studies. Multivariate Behav Res. 2011 May; 46(3): 399-","text_display":" Confounding in Observational Studies. Multivariate Behav Res. 2011 May; 46(3): 399","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[486,1736],[556,1736],[556,1775],[486,1775]],"region":{"top_left_x":485,"top_left_y":1735,"width":72,"height":40},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b117c83fb8824be7b8b97178d6ee6b65","type":"text","conversion_output":true,"text":"424.","text_display":"424.","confidence":1,"confidence_rate":1},{"cnt":[[434,1800],[1665,1800],[1665,1843],[434,1843]],"region":{"top_left_x":433,"top_left_y":1800,"width":1233,"height":44},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"257230bd53e54cbb9b95ee527dbaac87","type":"text","conversion_output":true,"text":"2. Bath PM, Gray LJ, Collier T, Pocock S, Carpenter J, and the Optimising Analysis of","text_display":"\n2. Bath PM, Gray LJ, Collier T, Pocock S, Carpenter J, and the Optimising Analysis of","confidence":1,"confidence_rate":1},{"cnt":[[486,1843],[1687,1843],[1687,1884],[486,1884]],"region":{"top_left_x":485,"top_left_y":1843,"width":1202,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa694bb694c14098ab00fc8d5d8877ad","type":"text","conversion_output":true,"text":"Stroke Trials (OAST) Collaboration. (2007) Can we improve the statistical analysis of","text_display":" Stroke Trials (OAST) Collaboration. (2007) Can we improve the statistical analysis of","confidence":1,"confidence_rate":1},{"cnt":[[486,1882],[1674,1882],[1674,1923],[486,1923]],"region":{"top_left_x":485,"top_left_y":1882,"width":1189,"height":41},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36cfa183ae7a452892253d063f529eef","type":"text","conversion_output":true,"text":"stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke; 38:","text_display":" stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke; 38:","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[486,1921],[655,1921],[655,1962],[486,1962]],"region":{"top_left_x":485,"top_left_y":1920,"width":171,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4753d735c56a4664829f99441798e5b7","type":"text","conversion_output":true,"text":"1911-1915.","text_display":" 1911-1915.","confidence":1,"confidence_rate":1},{"cnt":[[434,1985],[1704,1985],[1704,2030],[434,2030]],"region":{"top_left_x":433,"top_left_y":1985,"width":1271,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b5b1f9d9baa4aff860d5677574caebf","type":"text","conversion_output":true,"text":"3. Dhamoon MS, Moom YP, Boden-Albala B, et al. (2009) Long-term functional recovery","text_display":"\n3. Dhamoon MS, Moom YP, Boden-Albala B, et al. (2009) Long-term functional recovery","confidence":1,"confidence_rate":1},{"cnt":[[486,2028],[1594,2028],[1594,2069],[486,2069]],"region":{"top_left_x":485,"top_left_y":2028,"width":1110,"height":41},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95f4d3da48c448f7934b447ec62256a6","type":"text","conversion_output":true,"text":"after first ischemic stroke: the Northern Manhattan Study. Stroke; 40: 280-511.","text_display":" after first ischemic stroke: the Northern Manhattan Study. Stroke; 40: 280-511.","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[432,2093],[1601,2093],[1601,2133],[432,2133]],"region":{"top_left_x":431,"top_left_y":2092,"width":1170,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54de491d80054bc397a30d1fd7dce918","type":"text","conversion_output":true,"text":"4. Edlow JS, Smith EE, Stead LG, et al. (2013) Clinical policy: Use of t-PA for the","text_display":"\n4. Edlow JS, Smith EE, Stead LG, et al. (2013) Clinical policy: Use of t-PA for the","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[486,2136],[1717,2136],[1717,2176],[486,2176]],"region":{"top_left_x":485,"top_left_y":2135,"width":1232,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0004e5feec1b4d0c828d22e558b2f3c4","type":"text","conversion_output":true,"text":"management of acute ischemic stroke in the Emergency Department. Ann Emerg Med;","text_display":" management of acute ischemic stroke in the Emergency Department. Ann Emerg Med;","confidence":1,"confidence_rate":1},{"cnt":[[486,2174],[672,2174],[672,2211],[486,2211]],"region":{"top_left_x":485,"top_left_y":2174,"width":188,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df5320ac95624d70b615886bf4e30a17","type":"text","conversion_output":true,"text":"61: 225-243.","text_display":" 61: 225-243.","confidence":1,"confidence_rate":1},{"cnt":[[430,2329],[1205,2329],[1205,2374],[430,2374]],"region":{"top_left_x":429,"top_left_y":2328,"width":777,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9662b1cd7be840708ec9243349606885","type":"section_header","conversion_output":false,"children_ids":["567d79c16ddd4e1cb07224f3db67a08b"],"text":"","text_display":""},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"567d79c16ddd4e1cb07224f3db67a08b","type":"text","conversion_output":true,"parent_id":"9662b1cd7be840708ec9243349606885","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\n\\section*{Statistical Analysis Plan: Alteplase-Genentech USMA}","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e5aabb25a15464fac394b158e78c568","type":"text","conversion_output":true,"text":"31/ML29093","text_display":"\n\n31/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2f85c890e73460bb063e9a1324ee887","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f21801568b044b4d8762e2197364eb83","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9965858445502818,"confidence_rate":0.9999473860460373},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1072f8c4eab4faf98d4287fa04698cf","type":"page_info","conversion_output":false,"text":"792/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-33","page":33,"lines":[{"cnt":[[434,440],[1687,440],[1687,479],[434,479]],"region":{"top_left_x":433,"top_left_y":440,"width":1254,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9c25190766c4b64811dfe47067a899d","type":"text","conversion_output":true,"text":"5. Friedman LM, Furberg CD, DeMets DL. (1998) Fundamentals of Clinical Trials. Third","text_display":"\n5. Friedman LM, Furberg CD, DeMets DL. (1998) Fundamentals of Clinical Trials. Third","confidence":0.998046875,"confidence_rate":0.9999780335577174},{"cnt":[[486,481],[971,481],[971,522],[486,522]],"region":{"top_left_x":485,"top_left_y":481,"width":487,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23e7720329a74f6a9dc937482bfcb465","type":"text","conversion_output":true,"text":"ed., New York, NY: Springer: 108.","text_display":" ed., New York, NY: Springer: 108.","confidence":1,"confidence_rate":1},{"cnt":[[434,546],[1699,546],[1699,587],[434,587]],"region":{"top_left_x":433,"top_left_y":545,"width":1267,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2525eaeadd044c799df37f5bdee0cf9b","type":"text","conversion_output":true,"text":"6. Jauch EC, Saver JL, Adams HP, et al. (2013) Guidelines for the early management of","text_display":"\n6. Jauch EC, Saver JL, Adams HP, et al. (2013) Guidelines for the early management of","confidence":1,"confidence_rate":1},{"cnt":[[486,589],[1682,589],[1682,625],[486,625]],"region":{"top_left_x":485,"top_left_y":588,"width":1198,"height":38},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4079e14f10284784b6fbabdc15c40e2c","type":"text","conversion_output":true,"text":"patients with acute ischemic stroke: a guideline for healthcare professionals from the","text_display":" patients with acute ischemic stroke: a guideline for healthcare professionals from the","confidence":1,"confidence_rate":1},{"cnt":[[486,627],[1605,627],[1605,664],[486,664]],"region":{"top_left_x":485,"top_left_y":627,"width":1120,"height":37},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c24eaa337474416eb09a65ea6d85ce80","type":"text","conversion_output":true,"text":"American Heart Association/American Stroke Association. Stroke; 44: 870-947.","text_display":" American Heart Association/American Stroke Association. Stroke; 44: 870-947.","confidence":1,"confidence_rate":1},{"cnt":[[434,692],[1671,692],[1671,733],[434,733]],"region":{"top_left_x":433,"top_left_y":691,"width":1239,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbf811bb6f60472a8597b534bfcb69d4","type":"text","conversion_output":true,"text":"7. Jennett B., and Bond M. (1975) Assessment of outcome after severe brain damage.","text_display":"\n7. Jennett B., and Bond M. (1975) Assessment of outcome after severe brain damage.","confidence":0.994140625,"confidence_rate":0.999932455057251},{"cnt":[[486,733],[857,733],[857,771],[486,771]],"region":{"top_left_x":485,"top_left_y":732,"width":373,"height":40},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"989ce40ca3084130b023c61cc4597d8e","type":"text","conversion_output":true,"text":"Lancet; 1(7905): 480-484.","text_display":" Lancet; 1(7905): 480-484.","confidence":1,"confidence_rate":1},{"cnt":[[434,799],[1652,799],[1652,838],[434,838]],"region":{"top_left_x":433,"top_left_y":799,"width":1220,"height":39},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65770dd1cfe44c9989ab2273353bdc00","type":"text","conversion_output":true,"text":"8. McHugh GS, Butcher I, Steyerberg EW, et al. (2010) A simulation study evaluating","text_display":"\n8. McHugh GS, Butcher I, Steyerberg EW, et al. (2010) A simulation study evaluating","confidence":0.99853515625,"confidence_rate":0.9999833419832633},{"cnt":[[486,838],[1678,838],[1678,879],[486,879]],"region":{"top_left_x":485,"top_left_y":837,"width":1193,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"260ecb7fb9e343a1b8daf35dba5f19a8","type":"text","conversion_output":true,"text":"approaches to the analysis of ordinal outcome data in randomized controlled trials in","text_display":" approaches to the analysis of ordinal outcome data in randomized controlled trials in","confidence":0.9775600433349609,"confidence_rate":0.9997478588640042},{"cnt":[[486,881],[1566,881],[1566,917],[486,917]],"region":{"top_left_x":485,"top_left_y":880,"width":1082,"height":38},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7670ee28d6ed4ce891134c35d62c3d07","type":"text","conversion_output":true,"text":"traumatic brain injury: results from the IMPACT Project. Clin Trials; 7: 44-57.","text_display":" traumatic brain injury: results from the IMPACT Project. Clin Trials; 7: 44-57.","confidence":1,"confidence_rate":1},{"cnt":[[434,945],[1682,945],[1682,984],[434,984]],"region":{"top_left_x":433,"top_left_y":945,"width":1250,"height":39},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41c8f6a4b2cd4160aebdb34b7c8a9c74","type":"text","conversion_output":true,"text":"9. Pampallona S, Tsiatis AA, Kim K. (2001) Interim monitoring of group sequential trials","text_display":"\n9. Pampallona S, Tsiatis AA, Kim K. (2001) Interim monitoring of group sequential trials","confidence":1,"confidence_rate":1},{"cnt":[[486,984],[1656,984],[1656,1025],[486,1025]],"region":{"top_left_x":485,"top_left_y":983,"width":1172,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b8d3598c5664303a67fc4ed82ab51d6","type":"text","conversion_output":true,"text":"using spending functions for the type I and type II error probabilities. Drug Inf J; 35:","text_display":" using spending functions for the type I and type II error probabilities. Drug Inf J; 35:","confidence":1,"confidence_rate":1},{"cnt":[[488,1027],[655,1027],[655,1059],[488,1059]],"region":{"top_left_x":487,"top_left_y":1026,"width":169,"height":34},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bff7e7c28234dd3bc0316eff03d4f7b","type":"text","conversion_output":true,"text":"1113-1121.","text_display":" 1113-1121.","confidence":1,"confidence_rate":1},{"cnt":[[436,1091],[1493,1091],[1493,1130],[436,1130]],"region":{"top_left_x":436,"top_left_y":1091,"width":1058,"height":40},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbabaee432fe4304bc40a8be34c8e2b1","type":"text","conversion_output":true,"text":"10. Reeves M, Khoury J, Alwell K, et al. (2013) Distribution of NIHSS in the","text_display":"\n10. Reeves M, Khoury J, Alwell K, et al. (2013) Distribution of NIHSS in the","confidence":1,"confidence_rate":1},{"cnt":[[488,1130],[1343,1130],[1343,1171],[488,1171]],"region":{"top_left_x":487,"top_left_y":1130,"width":856,"height":41},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2aeaa185f16443998b5b9f78322ceb1a","type":"text","conversion_output":true,"text":"Cincinnati/Northern Kentucky Stroke Study. Stroke; In press.","text_display":" Cincinnati/Northern Kentucky Stroke Study. Stroke; In press.","confidence":0.9990234375,"confidence_rate":0.9999849687337733},{"cnt":[[436,1195],[1725,1195],[1725,1235],[436,1235]],"region":{"top_left_x":436,"top_left_y":1194,"width":1290,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e542315327c42b89713beca8564ef75","type":"text","conversion_output":true,"text":"11. Rubin D. (1987) Multiple Imputation for Nonresponse in Surveys. New York: John Wiley","text_display":"\n11. Rubin D. (1987) Multiple Imputation for Nonresponse in Surveys. New York: John Wiley","confidence":1,"confidence_rate":1},{"cnt":[[488,1238],[595,1238],[595,1270],[488,1270]],"region":{"top_left_x":487,"top_left_y":1237,"width":109,"height":33},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ca95d2fc6d94573938934979fee4b8d","type":"text","conversion_output":true,"text":"\\& Sons","text_display":" \\& Sons","confidence":1,"confidence_rate":1},{"cnt":[[438,1302],[1721,1302],[1721,1343],[438,1343]],"region":{"top_left_x":438,"top_left_y":1301,"width":1283,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4718c9d1282b4c50872ea684cdb48da4","type":"text","conversion_output":true,"text":"12. Tilley BC, Marler J, Geller NL, et al. (1996) Use of a global test for multiple outcomes in","text_display":"\n12. Tilley BC, Marler J, Geller NL, et al. (1996) Use of a global test for multiple outcomes in","confidence":1,"confidence_rate":1},{"cnt":[[486,1343],[1644,1343],[1644,1381],[486,1381]],"region":{"top_left_x":485,"top_left_y":1342,"width":1159,"height":40},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2347c8db3f5e4619a7cf7ce2daba51fa","type":"text","conversion_output":true,"text":"stroke trials with application to the National Institute of Neurological Disorders and","text_display":" stroke trials with application to the National Institute of Neurological Disorders and","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[486,1384],[1158,1384],[1158,1420],[486,1420]],"region":{"top_left_x":485,"top_left_y":1383,"width":674,"height":38},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ea37b6064894febaa17b9fe3245740d","type":"text","conversion_output":true,"text":"Stroke t-PA Stroke Trial. Stroke; 27:2136-2142.","text_display":" Stroke t-PA Stroke Trial. Stroke; 27:2136-2142.","confidence":0.99951171875,"confidence_rate":0.9999906077268363},{"cnt":[[438,1448],[1687,1448],[1687,1487],[438,1487]],"region":{"top_left_x":438,"top_left_y":1448,"width":1249,"height":39},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7751778cdbd4982978acb2bd154e8bc","type":"text","conversion_output":true,"text":"13. Ulm K. (1990) A simple method to calculate the confidence interval of a standardized","text_display":"\n13. Ulm K. (1990) A simple method to calculate the confidence interval of a standardized","confidence":0.998535871389322,"confidence_rate":0.9999842452693294},{"cnt":[[486,1487],[1137,1487],[1137,1528],[486,1528]],"region":{"top_left_x":485,"top_left_y":1486,"width":652,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a95246b492ff4a83b218505b1c2da430","type":"text","conversion_output":true,"text":"mortality ratio. Am J Epidemiol; 131: 373-375.","text_display":" mortality ratio. Am J Epidemiol; 131: 373-375.","confidence":1,"confidence_rate":1},{"cnt":[[438,1553],[1639,1553],[1639,1592],[438,1592]],"region":{"top_left_x":438,"top_left_y":1553,"width":1202,"height":39},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84507048fdd648b7bd2dbd476a6b0185","type":"text","conversion_output":true,"text":"14. Wei LJ (1978) The Adaptive Biased Coin Design for Sequential Experiments. The","text_display":"\n14. Wei LJ (1978) The Adaptive Biased Coin Design for Sequential Experiments. The","confidence":0.9234857559204102,"confidence_rate":0.9990748479442864},{"cnt":[[486,1594],[960,1594],[960,1635],[486,1635]],"region":{"top_left_x":485,"top_left_y":1594,"width":476,"height":41},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e7fc61b9cb0422e90cbfda8d66da777","type":"text","conversion_output":true,"text":"Annals of Statistics; 6(1): 92-100.","text_display":" Annals of Statistics; 6(1): 92-100.","confidence":1,"confidence_rate":1},{"cnt":[[438,1659],[1740,1659],[1740,1697],[438,1697]],"region":{"top_left_x":438,"top_left_y":1658,"width":1303,"height":40},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f84de2b90a5438095e893a00840de2e","type":"text","conversion_output":true,"text":"15. Efron B. (1971) Forcing sequential experiments to be balanced, Biometrika, 58, 403-417.","text_display":"\n15. Efron B. (1971) Forcing sequential experiments to be balanced, Biometrika, 58, 403-417.","confidence":1,"confidence_rate":1},{"cnt":[[438,1723],[1706,1723],[1706,1764],[438,1764]],"region":{"top_left_x":438,"top_left_y":1723,"width":1268,"height":41},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f83261723acf496abd6afce4d07647ec","type":"text","conversion_output":true,"text":"16. Zhao W., Ciolino J., and Palesch Y. (2010) Step-forward Randomization in Multicenter","text_display":"\n16. Zhao W., Ciolino J., and Palesch Y. (2010) Step-forward Randomization in Multicenter","confidence":1,"confidence_rate":1},{"cnt":[[486,1764],[1704,1764],[1704,1807],[486,1807]],"region":{"top_left_x":485,"top_left_y":1763,"width":1219,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32ecb5d9a5244412bc02930481478b44","type":"text","conversion_output":true,"text":"Emergency Treatment Clinical Trials. Academic Emergency Medicine; 17(6): 659-665.","text_display":" Emergency Treatment Clinical Trials. Academic Emergency Medicine; 17(6): 659-665.","confidence":1,"confidence_rate":1},{"cnt":[[438,1830],[1635,1830],[1635,1869],[438,1869]],"region":{"top_left_x":438,"top_left_y":1830,"width":1197,"height":40},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dd646b168f04b5797c47cc51eaa7bbf","type":"text","conversion_output":true,"text":"17. Zhao W., Weng Y. (2011) Block urn design - A new randomization algorithm for","text_display":"\n17. Zhao W., Weng Y. (2011) Block urn design - A new randomization algorithm for","confidence":0.99951171875,"confidence_rate":0.9999942541282946},{"cnt":[[486,1869],[1676,1869],[1676,1910],[486,1910]],"region":{"top_left_x":485,"top_left_y":1869,"width":1191,"height":41},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3651710c54f42d182cb75342ada4930","type":"text","conversion_output":true,"text":"sequential trials with two or more treatments and balanced or unbalanced allocation.","text_display":" sequential trials with two or more treatments and balanced or unbalanced allocation.","confidence":1,"confidence_rate":1},{"cnt":[[486,1912],[1111,1912],[1111,1949],[486,1949]],"region":{"top_left_x":485,"top_left_y":1912,"width":626,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f8090040bed44a7bad7431e3928ff02","type":"text","conversion_output":true,"text":"Contemporary clinical trials; 32(6): 953-961.","text_display":" Contemporary clinical trials; 32(6): 953-961.","confidence":0.99560546875,"confidence_rate":0.9999119195676102},{"cnt":[[438,1977],[1738,1977],[1738,2015],[438,2015]],"region":{"top_left_x":438,"top_left_y":1976,"width":1301,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8ead4d28c264f6885a722d93c27473e","type":"text","conversion_output":true,"text":"18. Calculating the U.S. Population-based EQ-5D Index Score: Research Initiative in Clinical","text_display":"\n18. Calculating the U.S. Population-based EQ-5D Index Score: Research Initiative in Clinical","confidence":1,"confidence_rate":1},{"cnt":[[486,2015],[1740,2015],[1740,2056],[486,2056]],"region":{"top_left_x":485,"top_left_y":2015,"width":1256,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54d842816ddc4a0ebbe97d5ba55722d8","type":"text","conversion_output":true,"text":"Economics. February 2005. Agency for Healthcare Research and Quality, Rockville, MD.","text_display":" Economics. February 2005. Agency for Healthcare Research and Quality, Rockville, MD.","confidence":1,"confidence_rate":1},{"cnt":[[488,2058],[1704,2058],[1704,2099],[488,2099]],"region":{"top_left_x":487,"top_left_y":2058,"width":1217,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e46fdc30de4f48f1a7dbd5ff3134c7ac","type":"text","conversion_output":true,"text":"http://www.ahrq.gov/professionals/clinicians-providers/resources/rice/EQ5Dscore.html","text_display":" http://www.ahrq.gov/professionals/clinicians-providers/resources/rice/EQ5Dscore.html","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[490,2097],[986,2097],[986,2138],[490,2138]],"region":{"top_left_x":489,"top_left_y":2096,"width":498,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe845f6cad724b3eae285e154908406b","type":"text","conversion_output":true,"text":"(last accessed on 8 October 2014).","text_display":" (last accessed on 8 October 2014).","confidence":1,"confidence_rate":1},{"cnt":[[438,2161],[1742,2161],[1742,2202],[438,2202]],"region":{"top_left_x":438,"top_left_y":2161,"width":1305,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0dea4d2bba8a499290dcc68e0e90f4d7","type":"text","conversion_output":true,"text":"19. Duncan PW, Wallace D, Lai SM, Johnson D, Embretson S, Laster LJ. The Stroke Impact","text_display":"\n19. Duncan PW, Wallace D, Lai SM, Johnson D, Embretson S, Laster LJ. The Stroke Impact","confidence":1,"confidence_rate":1},{"cnt":[[488,2204],[1663,2204],[1663,2241],[488,2241]],"region":{"top_left_x":487,"top_left_y":2204,"width":1176,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"623defb0de3e44e599555bff48a4a62b","type":"text","conversion_output":true,"text":"Scale version 2.0. Evaluation of reliability, validity, and sensitivity to change. Stroke","text_display":" Scale version 2.0. Evaluation of reliability, validity, and sensitivity to change. Stroke","confidence":1,"confidence_rate":1},{"cnt":[[490,2243],[793,2243],[793,2279],[490,2279]],"region":{"top_left_x":489,"top_left_y":2242,"width":304,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"662bd49e252b4a6da71da1b1a5d76403","type":"text","conversion_output":true,"text":"1999; 30: 2131-2140.","text_display":" 1999; 30: 2131-2140.","confidence":1,"confidence_rate":1},{"cnt":[[432,2331],[1205,2331],[1205,2374],[432,2374]],"region":{"top_left_x":431,"top_left_y":2331,"width":775,"height":44},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c68963405d64f67ac0be5a643c7b7ac","type":"section_header","conversion_output":false,"children_ids":["df265222e99c4c55b2bbeb256b6dedaa"],"text":"","text_display":""},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"df265222e99c4c55b2bbeb256b6dedaa","type":"text","conversion_output":true,"parent_id":"6c68963405d64f67ac0be5a643c7b7ac","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\n\\section*{Statistical Analysis Plan: Alteplase-Genentech USMA}","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"141a0d419bd14aaba9d50d202d1403b6","type":"page_info","conversion_output":false,"text":"32/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"599a30e34fc64827915b7ec2fe50ecc4","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cce7922888e74da696ab6191a4abfca3","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9941506325279192,"confidence_rate":0.9999097495800716},{"cnt":[[372,2608],[694,2608],[694,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":37},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"125e91f4ecbb47d688d7a223c8ed4fd0","type":"page_info","conversion_output":false,"text":"793/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-34","page":34,"lines":[{"cnt":[[434,438],[1740,438],[1740,483],[434,483]],"region":{"top_left_x":433,"top_left_y":438,"width":1308,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42bda6f1a22f4905a5e2e8c8f89be4be","type":"text","conversion_output":true,"text":"20. Mahoney FI, Barthel D. Functional evaluation: the Barthel Index. Maryland State Medical","text_display":"\n20. Mahoney FI, Barthel D. Functional evaluation: the Barthel Index. Maryland State Medical","confidence":1,"confidence_rate":1},{"cnt":[[486,481],[827,481],[827,518],[486,518]],"region":{"top_left_x":485,"top_left_y":481,"width":343,"height":37},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32e3afe6cb2e4792bb73e1fbdece070e","type":"text","conversion_output":true,"text":"Journal 1965;14: 56-61.","text_display":" Journal 1965;14: 56-61.","confidence":1,"confidence_rate":1},{"cnt":[[434,546],[1652,546],[1652,587],[434,587]],"region":{"top_left_x":433,"top_left_y":545,"width":1220,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"18b9693be93849b1ba013507da482394","type":"text","conversion_output":true,"text":"21. Liu GF, Wang J, Liu K, Snavely DB. Confidence intervals for an exposure adjusted","text_display":"\n21. Liu GF, Wang J, Liu K, Snavely DB. Confidence intervals for an exposure adjusted","confidence":1,"confidence_rate":1},{"cnt":[[486,587],[1699,587],[1699,627],[486,627]],"region":{"top_left_x":485,"top_left_y":586,"width":1215,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac0fd6c316f24efab0f90ba3e3bcd741","type":"text","conversion_output":true,"text":"incidence rate difference with applications to clinical trials. Statistics in Medicine 2006;","text_display":" incidence rate difference with applications to clinical trials. Statistics in Medicine 2006;","confidence":1,"confidence_rate":1},{"cnt":[[486,627],[711,627],[711,666],[486,666]],"region":{"top_left_x":485,"top_left_y":627,"width":227,"height":40},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4986415d339b46a6be47986339d088a6","type":"text","conversion_output":true,"text":"25(8): 1275-86.","text_display":" 25(8): 1275-86.","confidence":0.98974609375,"confidence_rate":0.9994847907805035},{"cnt":[[434,692],[1669,692],[1669,733],[434,733]],"region":{"top_left_x":433,"top_left_y":691,"width":1237,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecc45bd395854ee1a0c73a980a710c67","type":"text","conversion_output":true,"text":"22. Mukaka M, White SA, Mwapasa V, Kalilani-Phiri L, Terlouw DJ, Faragher EB Model","text_display":"\n22. Mukaka M, White SA, Mwapasa V, Kalilani-Phiri L, Terlouw DJ, Faragher EB Model","confidence":1,"confidence_rate":1},{"cnt":[[486,735],[1691,735],[1691,776],[486,776]],"region":{"top_left_x":485,"top_left_y":734,"width":1206,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43247fda756944aba26d850d41e6685d","type":"text","conversion_output":true,"text":"choices to obtain adjusted risk difference estimates from a binomial regression model","text_display":" choices to obtain adjusted risk difference estimates from a binomial regression model","confidence":1,"confidence_rate":1},{"cnt":[[486,773],[1652,773],[1652,814],[486,814]],"region":{"top_left_x":485,"top_left_y":773,"width":1168,"height":42},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c600434b7d2402f920d37e564ff251c","type":"text","conversion_output":true,"text":"with convergence problems: An assessment of methods of adjusted risk difference","text_display":" with convergence problems: An assessment of methods of adjusted risk difference","confidence":1,"confidence_rate":1},{"cnt":[[486,814],[1424,814],[1424,853],[486,853]],"region":{"top_left_x":485,"top_left_y":814,"width":940,"height":39},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"78af2963235e490dbb3acdd46a1aad28","type":"text","conversion_output":true,"text":"estimation. Journal of Medical Statistics and Informatics 2016; 4:5.","text_display":" estimation. Journal of Medical Statistics and Informatics 2016; 4:5.","confidence":1,"confidence_rate":1},{"cnt":[[434,879],[1661,879],[1661,920],[434,920]],"region":{"top_left_x":433,"top_left_y":878,"width":1228,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0aaefde67572433c9ed8d24605111fca","type":"text","conversion_output":true,"text":"23. Cheung YB. A modified least-squares regression approach to the estimation of risk","text_display":"\n23. Cheung YB. A modified least-squares regression approach to the estimation of risk","confidence":1,"confidence_rate":1},{"cnt":[[486,920],[1164,920],[1164,960],[486,960]],"region":{"top_left_x":485,"top_left_y":919,"width":680,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ec82f0372db437d81b149c4d05eb81f","type":"text","conversion_output":true,"text":"difference. Am J Epidemiol. 2007; 166:1337-44.","text_display":" difference. Am J Epidemiol. 2007; 166:1337-44.","confidence":0.99951171875,"confidence_rate":0.9999904235654993},{"cnt":[[434,984],[1732,984],[1732,1025],[434,1025]],"region":{"top_left_x":433,"top_left_y":983,"width":1299,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"978fdd30157d4afaaefdfb5e22e959b2","type":"text","conversion_output":true,"text":"24. Andridge RR, Little RJA. A Review of Hot Deck Imputation for Survey Non-response. Int","text_display":"\n24. Andridge RR, Little RJA. A Review of Hot Deck Imputation for Survey Non-response. Int","confidence":1,"confidence_rate":1},{"cnt":[[486,1025],[982,1025],[982,1068],[486,1068]],"region":{"top_left_x":485,"top_left_y":1024,"width":497,"height":44},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1921c00c53034852bd15a993279ff5bc","type":"text","conversion_output":true,"text":"Stat Rev. 2010 April; 78(1): 40-64.","text_display":" Stat Rev. 2010 April; 78(1): 40-64.","confidence":1,"confidence_rate":1},{"cnt":[[434,1089],[1712,1089],[1712,1130],[434,1130]],"region":{"top_left_x":433,"top_left_y":1089,"width":1280,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0d908f84382749108290cd10ee41adcc","type":"text","conversion_output":true,"text":"25. Wahlgren N, Ahmed N, Dávalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste","text_display":"\n25. Wahlgren N, Ahmed N, Dávalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[486,1130],[1695,1130],[1695,1171],[486,1171]],"region":{"top_left_x":485,"top_left_y":1130,"width":1211,"height":41},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70af30bb5c5440029e9e130bc77e633f","type":"text","conversion_output":true,"text":"M, Kuelkens S, Larrue V, Lees KR, Roine RO, Soinne L, Toni D, Vanhooren G; SITS-","text_display":" M, Kuelkens S, Larrue V, Lees KR, Roine RO, Soinne L, Toni D, Vanhooren G; SITS","confidence":1,"confidence_rate":1},{"cnt":[[486,1171],[1721,1171],[1721,1210],[486,1210]],"region":{"top_left_x":485,"top_left_y":1170,"width":1236,"height":40},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e783fc6fea8a4b019b82a6090abe525e","type":"text","conversion_output":true,"text":"MOST investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe","text_display":"MOST investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe","confidence":1,"confidence_rate":1},{"cnt":[[486,1212],[1583,1212],[1583,1253],[486,1253]],"region":{"top_left_x":485,"top_left_y":1211,"width":1099,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22518d2e83cc4e03a73682d970a6a04d","type":"text","conversion_output":true,"text":"Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an","text_display":" Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an","confidence":1,"confidence_rate":1},{"cnt":[[486,1250],[1360,1250],[1360,1291],[486,1291]],"region":{"top_left_x":485,"top_left_y":1250,"width":875,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"120643c39db84aa4874251b445c259d6","type":"text","conversion_output":true,"text":"observational study. Lancet 2007 Jan 27; 369 (9558): 275-82.","text_display":" observational study. Lancet 2007 Jan 27; 369 (9558): 275-82.","confidence":0.9990236759185791,"confidence_rate":0.9999862423341275},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a23b4a83aa2421cae711535e587a4a0","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e4971d0617446b6ace8852bcecbc05a","type":"page_info","conversion_output":false,"text":"33/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f486966b0934934860676d0061ec0bb","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"296f8a125c9941829642a9af8cdff6df","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9946386743121138,"confidence_rate":0.9999172995864799},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b24fcc8e280e4b9c8323cfba63938b17","type":"page_info","conversion_output":false,"text":"794/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-35","page":35,"lines":[{"cnt":[[932,440],[1244,440],[1244,529],[932,529]],"region":{"top_left_x":932,"top_left_y":440,"width":312,"height":89},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d949346a35ee4e25993edc72704eec05","type":"section_header","conversion_output":false,"children_ids":["2ee2f45928a1489ebbeedbd1db642768","4ce645d896534ad991d2a21bdc01904a"],"text":"","text_display":""},{"cnt":[[988,443],[1188,443],[1188,483],[988,483]],"region":{"top_left_x":988,"top_left_y":442,"width":201,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ee2f45928a1489ebbeedbd1db642768","type":"text","conversion_output":true,"parent_id":"d949346a35ee4e25993edc72704eec05","text":"Appendix A","text_display":"\n\n\\section*{Appendix A","confidence":1,"confidence_rate":1},{"cnt":[[932,486],[1240,486],[1240,526],[932,526]],"region":{"top_left_x":932,"top_left_y":485,"width":308,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ce645d896534ad991d2a21bdc01904a","type":"text","conversion_output":true,"parent_id":"d949346a35ee4e25993edc72704eec05","text":"Protocol Synopsis","text_display":" Protocol Synopsis}","confidence":1,"confidence_rate":1},{"cnt":[[907,602],[1231,602],[1231,634],[907,634]],"region":{"top_left_x":906,"top_left_y":601,"width":326,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5a4e3b32df7d46c2a78cf07b9a737a08","type":"section_header","conversion_output":false,"children_ids":["a3fbe884a18649ae930bc812b67d6f64"],"text":"","text_display":""},{"cnt":[[907,606],[1231,606],[1231,632],[907,632]],"region":{"top_left_x":906,"top_left_y":605,"width":326,"height":27},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a3fbe884a18649ae930bc812b67d6f64","type":"text","conversion_output":true,"parent_id":"5a4e3b32df7d46c2a78cf07b9a737a08","text":"PROTOCOL SYNOPSIS","text_display":"\n\n\\section*{PROTOCOL SYNOPSIS}","confidence":1,"confidence_rate":1},{"cnt":[[440,660],[1184,660],[1184,1575],[440,1575]],"region":{"top_left_x":440,"top_left_y":659,"width":744,"height":916},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ef215f096cc54ee397b9996d8877d141","type":"table","conversion_output":true,"children_ids":["673fb114b1504b9387e3975f7308ed59","741a3a5589c84d00ad39e0502998b09a","3a944ff5cd4d47ec9c278b7b51c403cf","957ba46195c04b84826d6c9f67f18d05","cbb22c8bed91416fa94b4e15d4dccd9a","7c34e3143b2f4570a2e963f94c5076d8","2af953e6b41c4a0b8d186eaff4006921","1f8f4fe66f564160ab13245513fd2c89","c169070aaee84b4b96e1de02d1b62bfd","67bcaef43874433791ba54944a5faefb","7f30c8819f1b49cfa3408cb803793705","128b2b5c47c847cb9725ba038e8e9c76","d94daf69269f48b785c8bc55da7aac5d","48933e5623664ba5b0b738fc1968e0a7","aba4d6169700431d8e64bc0ed1b3568d","23a0825506704bc397aefc2191213c43","76edc3aec57d404e840bf12f321d9d85","27008e6bd58741738378fd834187feb2","fecc60ceb2254ea38cedf653a2f074de","6b2d6aef9dc0441dbb283581658bbb0e","7b011144c1134451b58ed98dca60154c","b02cb2e077ff4ff88b05c52b541fee52","2335440065fb4e28bb04d8ea4026d8be","d019526c2dcd43acbc33943647731826","00fde9ccfd694fbbb8dd50b742cbe730","6a2191963a1e470c834c139a08d78ca6","58a19b63ca2044a5a93d8e6247532159","1e0c3bc7e05f4422b9c61804f0af11a4","55417ff5c7b847b98b8fbd31c7fe25f5","b314e4b3f28c43fa9cfaf13d9d211a57","7df4780fff1c4fbc8eec98f76b3bb662","a2ee4a99000041778ac669b40f577727","ca39138e594744aeada107d3ae4a0167","12e5f0c490cc4efda9f4aec60e3f5d3d","ce421b1697214f63883c792c22891a38","5057df5424794eadb3e9dc0a45420f57","c20f09bb89204f4d9f91094135473e8b"],"text":"\\begin{tabular}{|l|l|}\n\\hline TITLE: & A PHASE IIIB, DOUBLE STUDY TO EVALUATE OF ALTEPLASE IN PAT (RAPIDLY IMPROVING NEUROLOGIC DEFICIT \\\\\n\\hline PROTOCOL NUMBER: & ML29093 \\\\\n\\hline VERSION NUMBER: & 3 \\\\\n\\hline EUDRACT NUMBER: & N/A \\\\\n\\hline IND NUMBER: & 3811 \\\\\n\\hline TEST PRODUCT: & Alteplase (RO5532960) \\\\\n\\hline PHASE: & lllb \\\\\n\\hline INDICATION: & Acute ischemic stroke \\\\\n\\hline SPONSOR: & Genentech, Inc. \\\\\n\\hline DATE FINAL: & Version 1: 27 November 2013 \\\\\n\\hline DATE AMENDED: & Version 2: 22 August 2014 \\\\\n\\hline & Version 3: 17 December 2014 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline TITLE: & A PHASE IIIB, DOUBLE STUDY TO EVALUATE OF ALTEPLASE IN PAT (RAPIDLY IMPROVING NEUROLOGIC DEFICIT \\\\\n\\hline PROTOCOL NUMBER: & ML29093 \\\\\n\\hline VERSION NUMBER: & 3 \\\\\n\\hline EUDRACT NUMBER: & N/A \\\\\n\\hline IND NUMBER: & 3811 \\\\\n\\hline TEST PRODUCT: & Alteplase (RO5532960) \\\\\n\\hline PHASE: & lllb \\\\\n\\hline INDICATION: & Acute ischemic stroke \\\\\n\\hline SPONSOR: & Genentech, Inc. \\\\\n\\hline DATE FINAL: & Version 1: 27 November 2013 \\\\\n\\hline DATE AMENDED: & Version 2: 22 August 2014 \\\\\n\\hline & Version 3: 17 December 2014 \\\\\n\\hline\n\\end{tabular}","confidence":0.8902663812041283,"confidence_rate":0.9994341556455332},{"cnt":[[440,659],[760,659],[760,1575],[440,1575]],"region":{"top_left_x":440,"top_left_y":659,"width":320,"height":917},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"673fb114b1504b9387e3975f7308ed59","type":"table_column","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[789,659],[1186,659],[1186,1577],[789,1577]],"region":{"top_left_x":788,"top_left_y":659,"width":398,"height":918},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"741a3a5589c84d00ad39e0502998b09a","type":"table_column","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,659],[1186,659],[1186,884],[440,884]],"region":{"top_left_x":440,"top_left_y":659,"width":746,"height":226},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3a944ff5cd4d47ec9c278b7b51c403cf","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,910],[1186,910],[1186,949],[440,949]],"region":{"top_left_x":440,"top_left_y":909,"width":746,"height":41},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"957ba46195c04b84826d6c9f67f18d05","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,975],[1186,975],[1186,1011],[440,1011]],"region":{"top_left_x":440,"top_left_y":975,"width":746,"height":37},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cbb22c8bed91416fa94b4e15d4dccd9a","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1037],[1186,1037],[1186,1077],[440,1077]],"region":{"top_left_x":440,"top_left_y":1037,"width":746,"height":40},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7c34e3143b2f4570a2e963f94c5076d8","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1102],[1186,1102],[1186,1142],[440,1142]],"region":{"top_left_x":440,"top_left_y":1102,"width":746,"height":40},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2af953e6b41c4a0b8d186eaff4006921","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1164],[1186,1164],[1186,1211],[440,1211]],"region":{"top_left_x":440,"top_left_y":1164,"width":746,"height":47},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1f8f4fe66f564160ab13245513fd2c89","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1228],[1186,1228],[1186,1269],[440,1269]],"region":{"top_left_x":440,"top_left_y":1227,"width":746,"height":43},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c169070aaee84b4b96e1de02d1b62bfd","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1293],[1186,1293],[1186,1334],[440,1334]],"region":{"top_left_x":440,"top_left_y":1293,"width":746,"height":42},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"67bcaef43874433791ba54944a5faefb","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1355],[1186,1355],[1186,1398],[440,1398]],"region":{"top_left_x":440,"top_left_y":1355,"width":746,"height":44},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7f30c8819f1b49cfa3408cb803793705","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1419],[1188,1419],[1188,1460],[440,1460]],"region":{"top_left_x":440,"top_left_y":1418,"width":748,"height":42},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"128b2b5c47c847cb9725ba038e8e9c76","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1484],[1186,1484],[1186,1527],[440,1527]],"region":{"top_left_x":440,"top_left_y":1484,"width":746,"height":43},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d94daf69269f48b785c8bc55da7aac5d","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[440,1541],[1188,1541],[1188,1575],[440,1575]],"region":{"top_left_x":440,"top_left_y":1540,"width":748,"height":36},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"48933e5623664ba5b0b738fc1968e0a7","type":"table_row","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"","text_display":""},{"cnt":[[443,666],[538,666],[538,695],[443,695]],"region":{"top_left_x":443,"top_left_y":665,"width":95,"height":31},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aba4d6169700431d8e64bc0ed1b3568d","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"TITLE:","text_display":"TITLE:","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[791,659],[1186,659],[1186,884],[791,884]],"region":{"top_left_x":790,"top_left_y":659,"width":396,"height":226},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23a0825506704bc397aefc2191213c43","type":"complex_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","children_ids":["30cc9b102a3f418aab9594467ed4beaa","8562b8ebf4b34eafaccd5f6967a03f51","b7ae6267725744ea9fb2344f75bff15a","10d3a736ec6f47b681f59332905bbe31","353bad0d30be470cbe4fecf4203f204a"],"text":"A PHASE IIIB, DOUBLE STUDY TO EVALUATE OF ALTEPLASE IN PAT (RAPIDLY IMPROVING NEUROLOGIC DEFICIT","text_display":"A PHASE IIIB, DOUBLE STUDY TO EVALUATE OF ALTEPLASE IN PAT (RAPIDLY IMPROVING NEUROLOGIC DEFICIT","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99169921875,"confidence_rate":0.9999156352847083},{"cnt":[[794,662],[1184,662],[1184,699],[794,699]],"region":{"top_left_x":794,"top_left_y":662,"width":391,"height":37},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"30cc9b102a3f418aab9594467ed4beaa","type":"text","conversion_output":false,"parent_id":"23a0825506704bc397aefc2191213c43","text":"A PHASE IIIB, DOUBLE","text_display":"A PHASE IIIB, DOUBLE","confidence":0.9990234375,"confidence_rate":0.9999609191777622},{"cnt":[[794,707],[1174,707],[1174,743],[794,743]],"region":{"top_left_x":794,"top_left_y":707,"width":380,"height":37},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8562b8ebf4b34eafaccd5f6967a03f51","type":"text","conversion_output":false,"parent_id":"23a0825506704bc397aefc2191213c43","text":"STUDY TO EVALUATE","text_display":" STUDY TO EVALUATE","confidence":1,"confidence_rate":1},{"cnt":[[794,755],[1181,755],[1181,788],[794,788]],"region":{"top_left_x":794,"top_left_y":755,"width":387,"height":33},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7ae6267725744ea9fb2344f75bff15a","type":"text","conversion_output":false,"parent_id":"23a0825506704bc397aefc2191213c43","text":"OF ALTEPLASE IN PAT","text_display":" OF ALTEPLASE IN PAT","confidence":0.99951171875,"confidence_rate":0.9999796501863057},{"cnt":[[794,800],[1172,800],[1172,841],[794,841]],"region":{"top_left_x":794,"top_left_y":799,"width":379,"height":43},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10d3a736ec6f47b681f59332905bbe31","type":"text","conversion_output":false,"parent_id":"23a0825506704bc397aefc2191213c43","text":"(RAPIDLY IMPROVING","text_display":" (RAPIDLY IMPROVING","confidence":1,"confidence_rate":1},{"cnt":[[794,848],[1181,848],[1181,881],[794,881]],"region":{"top_left_x":794,"top_left_y":848,"width":387,"height":33},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"353bad0d30be470cbe4fecf4203f204a","type":"text","conversion_output":false,"parent_id":"23a0825506704bc397aefc2191213c43","text":"NEUROLOGIC DEFICIT","text_display":" NEUROLOGIC DEFICIT","confidence":0.99169921875,"confidence_rate":0.9996376558981812},{"cnt":[[445,917],[758,917],[758,944],[445,944]],"region":{"top_left_x":445,"top_left_y":916,"width":313,"height":29},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76edc3aec57d404e840bf12f321d9d85","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"PROTOCOL NUMBER:","text_display":"PROTOCOL NUMBER:","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,917],[920,917],[920,944],[794,944]],"region":{"top_left_x":794,"top_left_y":916,"width":126,"height":29},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27008e6bd58741738378fd834187feb2","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"ML29093","text_display":"ML29093","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,979],[724,979],[724,1008],[443,1008]],"region":{"top_left_x":443,"top_left_y":978,"width":281,"height":30},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fecc60ceb2254ea38cedf653a2f074de","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"VERSION NUMBER:","text_display":"VERSION NUMBER:","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[791,979],[818,979],[818,1010],[791,1010]],"region":{"top_left_x":790,"top_left_y":978,"width":29,"height":32},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b2d6aef9dc0441dbb283581658bbb0e","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"3","text_display":"3","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1041],[734,1041],[734,1073],[443,1073]],"region":{"top_left_x":443,"top_left_y":1040,"width":291,"height":34},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b011144c1134451b58ed98dca60154c","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"EUDRACT NUMBER:","text_display":"EUDRACT NUMBER:","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[791,1035],[851,1035],[851,1077],[791,1077]],"region":{"top_left_x":790,"top_left_y":1035,"width":61,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b02cb2e077ff4ff88b05c52b541fee52","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"N/A","text_display":"N/A","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1106],[641,1106],[641,1135],[443,1135]],"region":{"top_left_x":443,"top_left_y":1105,"width":199,"height":31},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2335440065fb4e28bb04d8ea4026d8be","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"IND NUMBER:","text_display":"IND NUMBER:","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1106],[861,1106],[861,1135],[794,1135]],"region":{"top_left_x":794,"top_left_y":1105,"width":68,"height":31},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d019526c2dcd43acbc33943647731826","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"3811","text_display":"3811","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1169],[682,1169],[682,1200],[443,1200]],"region":{"top_left_x":443,"top_left_y":1169,"width":240,"height":32},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"00fde9ccfd694fbbb8dd50b742cbe730","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"TEST PRODUCT:","text_display":"TEST PRODUCT:","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1169],[1102,1169],[1102,1206],[794,1206]],"region":{"top_left_x":794,"top_left_y":1169,"width":308,"height":37},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a2191963a1e470c834c139a08d78ca6","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"Alteplase (RO5532960)","text_display":"Alteplase (RO5532960)","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[443,1233],[557,1233],[557,1262],[443,1262]],"region":{"top_left_x":443,"top_left_y":1233,"width":114,"height":30},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58a19b63ca2044a5a93d8e6247532159","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"PHASE:","text_display":"PHASE:","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[791,1230],[844,1230],[844,1264],[791,1264]],"region":{"top_left_x":790,"top_left_y":1229,"width":54,"height":35},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e0c3bc7e05f4422b9c61804f0af11a4","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"lllb","text_display":"lllb","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.8902663812041283,"confidence_rate":0.9871680894034542},{"cnt":[[443,1297],[627,1297],[627,1328],[443,1328]],"region":{"top_left_x":443,"top_left_y":1296,"width":185,"height":32},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55417ff5c7b847b98b8fbd31c7fe25f5","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"INDICATION:","text_display":"INDICATION:","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1297],[1081,1297],[1081,1328],[794,1328]],"region":{"top_left_x":794,"top_left_y":1296,"width":288,"height":32},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b314e4b3f28c43fa9cfaf13d9d211a57","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"Acute ischemic stroke","text_display":"Acute ischemic stroke","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1360],[602,1360],[602,1393],[443,1393]],"region":{"top_left_x":443,"top_left_y":1360,"width":159,"height":33},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7df4780fff1c4fbc8eec98f76b3bb662","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"SPONSOR:","text_display":"SPONSOR:","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1360],[1005,1360],[1005,1395],[794,1395]],"region":{"top_left_x":794,"top_left_y":1360,"width":212,"height":35},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2ee4a99000041778ac669b40f577727","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"Genentech, Inc.","text_display":"Genentech, Inc.","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1426],[629,1426],[629,1455],[443,1455]],"region":{"top_left_x":443,"top_left_y":1425,"width":187,"height":30},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca39138e594744aeada107d3ae4a0167","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"DATE FINAL:","text_display":"DATE FINAL:","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1424],[1184,1424],[1184,1455],[794,1455]],"region":{"top_left_x":794,"top_left_y":1423,"width":391,"height":32},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12e5f0c490cc4efda9f4aec60e3f5d3d","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"Version 1: 27 November 2013","text_display":"Version 1: 27 November 2013","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1487],[691,1487],[691,1520],[443,1520]],"region":{"top_left_x":443,"top_left_y":1487,"width":248,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce421b1697214f63883c792c22891a38","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"DATE AMENDED:","text_display":"DATE AMENDED:","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1487],[1143,1487],[1143,1524],[794,1524]],"region":{"top_left_x":794,"top_left_y":1487,"width":349,"height":37},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5057df5424794eadb3e9dc0a45420f57","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"Version 2: 22 August 2014","text_display":"Version 2: 22 August 2014","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[794,1542],[1184,1542],[1184,1573],[794,1573]],"region":{"top_left_x":794,"top_left_y":1542,"width":391,"height":32},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c20f09bb89204f4d9f91094135473e8b","type":"simple_cell","conversion_output":false,"parent_id":"ef215f096cc54ee397b9996d8877d141","text":"Version 3: 17 December 2014","text_display":"Version 3: 17 December 2014","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[443,1603],[599,1603],[599,1639],[443,1639]],"region":{"top_left_x":442,"top_left_y":1602,"width":158,"height":38},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9f3c5daf0a3046079169d3492722fb25","type":"section_header","conversion_output":false,"children_ids":["cfa0fe52a5a9423a908a67a6926cb2c2"],"text":"","text_display":""},{"cnt":[[447,1605],[595,1605],[595,1635],[447,1635]],"region":{"top_left_x":446,"top_left_y":1604,"width":150,"height":31},"line":50,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cfa0fe52a5a9423a908a67a6926cb2c2","type":"text","conversion_output":true,"parent_id":"9f3c5daf0a3046079169d3492722fb25","text":"Objectives","text_display":"\n\n\\section*{Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[443,1646],[711,1646],[711,1682],[443,1682]],"region":{"top_left_x":442,"top_left_y":1645,"width":270,"height":38},"line":51,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"296fb71198774fdda39d5c08294e5f00","type":"section_header","conversion_output":false,"children_ids":["a23ba0d212f34028ab208c15b60401f7"],"text":"","text_display":""},{"cnt":[[447,1646],[711,1646],[711,1680],[447,1680]],"region":{"top_left_x":446,"top_left_y":1645,"width":266,"height":36},"line":52,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a23ba0d212f34028ab208c15b60401f7","type":"text","conversion_output":true,"parent_id":"296fb71198774fdda39d5c08294e5f00","text":"Primary Objectives","text_display":"\n\n\\section*{Primary Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[447,1684],[1652,1684],[1652,1717],[447,1717]],"region":{"top_left_x":446,"top_left_y":1684,"width":1207,"height":33},"line":53,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3cac0d0ea9694f209f531d7d1bdfea81","type":"text","conversion_output":true,"text":"The primary objective of this study is to determine the efficacy of intravenous (IV) alteplase for","text_display":"\n\nThe primary objective of this study is to determine the efficacy of intravenous (IV) alteplase for","confidence":1,"confidence_rate":1},{"cnt":[[447,1717],[1605,1717],[1605,1749],[447,1749]],"region":{"top_left_x":446,"top_left_y":1716,"width":1159,"height":33},"line":54,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"338587f889a64667b40df1edaead6e1f","type":"text","conversion_output":true,"text":"treatment of acute ischemic stroke (AIS) in patients with mild stroke (also known as \"minor","text_display":" treatment of acute ischemic stroke (AIS) in patients with mild stroke (also known as \"minor","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[447,1749],[1661,1749],[1661,1781],[447,1781]],"region":{"top_left_x":446,"top_left_y":1748,"width":1215,"height":34},"line":55,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bba3ae1149984be1a0155d5301367058","type":"text","conversion_output":true,"text":"neurologic deficit\" and \"rapidly improving stroke symptoms\"), defined as a National Institutes of","text_display":" neurologic deficit\" and \"rapidly improving stroke symptoms\"), defined as a National Institutes of","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[447,1779],[1695,1779],[1695,1813],[447,1813]],"region":{"top_left_x":446,"top_left_y":1778,"width":1250,"height":36},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a5329b2172c7431f8642015df22d7b23","type":"text","conversion_output":true,"text":"Health Stroke Scale (NIHSS) score \\(\\leq 5\\) and not clearly disabling, within 3 hours of last known well","text_display":" Health Stroke Scale (NIHSS) score \\(\\leq 5\\) and not clearly disabling, within 3 hours of last known well","confidence":0.8028304576873779,"confidence_rate":0.9979686241584472},{"cnt":[[447,1811],[1721,1811],[1721,1846],[447,1846]],"region":{"top_left_x":446,"top_left_y":1811,"width":1275,"height":35},"line":57,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4a14eb6d3a31468eb833557476be84e0","type":"text","conversion_output":true,"text":"time as measured by the proportion of patients with a modified Rankin Scale (mRS) score of 0-1 at","text_display":" time as measured by the proportion of patients with a modified Rankin Scale (mRS) score of 0-1 at","confidence":0.979520550230518,"confidence_rate":0.9997971572274326},{"cnt":[[447,1843],[548,1843],[548,1876],[447,1876]],"region":{"top_left_x":446,"top_left_y":1843,"width":102,"height":33},"line":58,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b611d7fb6e2c45c7972be330cee802e3","type":"text","conversion_output":true,"text":"Day 90.","text_display":" Day 90.","confidence":1,"confidence_rate":1},{"cnt":[[443,1886],[754,1886],[754,1923],[443,1923]],"region":{"top_left_x":442,"top_left_y":1886,"width":313,"height":37},"line":59,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c7660a597ace49cba578b972b95b8327","type":"section_header","conversion_output":false,"children_ids":["36d549ee3ff845d4a2aecb5d5c5256bd"],"text":"","text_display":""},{"cnt":[[447,1886],[750,1886],[750,1919],[447,1919]],"region":{"top_left_x":446,"top_left_y":1886,"width":304,"height":33},"line":60,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"36d549ee3ff845d4a2aecb5d5c5256bd","type":"text","conversion_output":true,"parent_id":"c7660a597ace49cba578b972b95b8327","text":"Secondary Objectives","text_display":"\n\n\\section*{Secondary Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[447,1925],[1132,1925],[1132,1957],[447,1957]],"region":{"top_left_x":446,"top_left_y":1925,"width":687,"height":33},"line":61,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"209402029bad4847ad4a050430de1a3a","type":"text","conversion_output":true,"text":"The secondary objectives of this study are as follows:","text_display":"\n\nThe secondary objectives of this study are as follows:","confidence":1,"confidence_rate":1},{"cnt":[[451,1964],[1601,1964],[1601,2000],[451,2000]],"region":{"top_left_x":451,"top_left_y":1963,"width":1150,"height":38},"line":62,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e814e2cfb55f44099e3d91523d69a100","type":"text","conversion_output":true,"text":"To further evaluate efficacy of IV alteplase to improve mild stroke outcomes at Day 90 via:","text_display":" To further evaluate efficacy of IV alteplase to improve mild stroke outcomes at Day 90 via:","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[541,2007],[707,2007],[707,2035],[541,2035]],"region":{"top_left_x":541,"top_left_y":2006,"width":166,"height":29},"line":63,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"236fc34d22a342379a315d29ebb7884d","type":"text","conversion_output":true,"text":"Ordinal mRS","text_display":"\n\nOrdinal mRS","confidence":0.9990236759185791,"confidence_rate":0.9999389518012535},{"cnt":[[541,2050],[1674,2050],[1674,2082],[541,2082]],"region":{"top_left_x":541,"top_left_y":2049,"width":1133,"height":33},"line":64,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"31ae26a1679a4fa7ac1cfde203af254d","type":"text","conversion_output":true,"text":"Global favorable recovery (Global Outcome Measure derived from mRS 0-1, NIHSS 0-1,","text_display":"\nGlobal favorable recovery (Global Outcome Measure derived from mRS 0-1, NIHSS 0-1,","confidence":1,"confidence_rate":1},{"cnt":[[541,2080],[1360,2080],[1360,2116],[541,2116]],"region":{"top_left_x":541,"top_left_y":2079,"width":819,"height":38},"line":65,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3c9b2a2d42cc4419ac788e07220cfdff","type":"text","conversion_output":true,"text":"Barthel Index [BI] \\(\\geq 95\\), and Glasgow Outcome Scale [GOS] = 1)","text_display":" Barthel Index [BI] \\(\\geq 95\\), and Glasgow Outcome Scale [GOS] = 1)","confidence":0.8366369615361652,"confidence_rate":0.9974183376529601},{"cnt":[[451,2148],[913,2148],[913,2181],[451,2181]],"region":{"top_left_x":451,"top_left_y":2148,"width":463,"height":33},"line":66,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1aea9ab20ae64bc68d0679aeb4d9f785","type":"text","conversion_output":true,"text":"To evaluate safety as measured by:","text_display":"\n\nTo evaluate safety as measured by:","confidence":1,"confidence_rate":1},{"cnt":[[541,2191],[1695,2191],[1695,2224],[541,2224]],"region":{"top_left_x":541,"top_left_y":2191,"width":1155,"height":33},"line":67,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1656ad78461849dd87db98042480e53c","type":"text","conversion_output":true,"text":"Symptomatic intracranial hemorrhage (sICH) within 36 hours - primary safety assessment","text_display":"\nSymptomatic intracranial hemorrhage (sICH) within 36 hours - primary safety assessment","confidence":0.9970724578015506,"confidence_rate":0.9999688107435011},{"cnt":[[541,2230],[1188,2230],[1188,2264],[541,2264]],"region":{"top_left_x":541,"top_left_y":2230,"width":648,"height":35},"line":68,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d19efeff1c93403f964a021838cb27b5","type":"text","conversion_output":true,"text":"Any intracranial hemorrhage (ICH) within 36 hours","text_display":"\nAny intracranial hemorrhage (ICH) within 36 hours","confidence":0.9990234375,"confidence_rate":0.9999828591004538},{"cnt":[[541,2273],[844,2273],[844,2305],[541,2305]],"region":{"top_left_x":541,"top_left_y":2273,"width":304,"height":33},"line":69,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"754835dd718e4e7c8c7e2688d8d1561e","type":"text","conversion_output":true,"text":"Mortality within 90 days","text_display":"\nMortality within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[436,2372],[1199,2372],[1199,2404],[436,2404]],"region":{"top_left_x":436,"top_left_y":2371,"width":763,"height":34},"line":70,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"de33b0bf63e542f69a7c01c73eda6dde","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":0.9990236759185791,"confidence_rate":0.9999825572771935},{"cnt":[[436,2406],[599,2406],[599,2434],[436,2434]],"region":{"top_left_x":436,"top_left_y":2406,"width":164,"height":29},"line":71,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"50e55b54838c42f8946953de7a249fc3","type":"page_info","conversion_output":false,"text":"34/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1048,2406],[1179,2406],[1179,2434],[1048,2434]],"region":{"top_left_x":1048,"top_left_y":2406,"width":132,"height":29},"line":72,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"470982f338bd4a1aad7f8e274f89bae7","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[372,2574],[1416,2574],[1416,2615],[372,2615]],"region":{"top_left_x":371,"top_left_y":2573,"width":1045,"height":42},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e760c32311fd472399446539fbbe72e8","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9926945971149053,"confidence_rate":0.9998872030079443},{"cnt":[[374,2608],[690,2608],[690,2640],[374,2640]],"region":{"top_left_x":373,"top_left_y":2608,"width":317,"height":33},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"835d9f5818194a23a0805665423d52a6","type":"page_info","conversion_output":false,"text":"795/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-36","page":36,"lines":[{"cnt":[[537,438],[1231,438],[1231,473],[537,473]],"region":{"top_left_x":537,"top_left_y":438,"width":695,"height":35},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0034a0603247420fa680bb0f266fee39","type":"text","conversion_output":true,"text":"Stroke-related and neurological deaths within 90 days","text_display":"\n\nStroke-related and neurological deaths within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[537,477],[1691,477],[1691,513],[537,513]],"region":{"top_left_x":537,"top_left_y":476,"width":1154,"height":38},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8b0156eb369643cea09afbfd587c9f02","type":"text","conversion_output":true,"text":"Incidence, severity, and spectrum of all adverse events (AEs) and serious adverse events","text_display":"\nIncidence, severity, and spectrum of all adverse events (AEs) and serious adverse events","confidence":1,"confidence_rate":1},{"cnt":[[537,511],[638,511],[638,544],[537,544]],"region":{"top_left_x":537,"top_left_y":511,"width":102,"height":33},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ce86e797323245d8aa3b2c278fc7e7d2","type":"text","conversion_output":true,"text":"(SAEs)","text_display":" (SAEs)","confidence":1,"confidence_rate":1},{"cnt":[[443,576],[769,576],[769,617],[443,617]],"region":{"top_left_x":442,"top_left_y":575,"width":328,"height":42},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fc63d1498a4a43a2ba0b5267f108589a","type":"section_header","conversion_output":false,"children_ids":["bb16992f0a4b438282b023f68e6011bd"],"text":"","text_display":""},{"cnt":[[443,580],[767,580],[767,612],[443,612]],"region":{"top_left_x":442,"top_left_y":580,"width":325,"height":33},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bb16992f0a4b438282b023f68e6011bd","type":"text","conversion_output":true,"parent_id":"fc63d1498a4a43a2ba0b5267f108589a","text":"Exploratory Objectives","text_display":"\n\n\\section*{Exploratory Objectives}","confidence":1,"confidence_rate":1},{"cnt":[[443,614],[1721,614],[1721,651],[443,651]],"region":{"top_left_x":442,"top_left_y":614,"width":1279,"height":37},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9047cc880e0b484da3c8bf03c37d9b5c","type":"text","conversion_output":true,"text":"The exploratory objectives for this study include subgroup analyses of the primary efficacy outcome","text_display":"\n\nThe exploratory objectives for this study include subgroup analyses of the primary efficacy outcome","confidence":1,"confidence_rate":1},{"cnt":[[443,649],[1699,649],[1699,683],[443,683]],"region":{"top_left_x":442,"top_left_y":648,"width":1258,"height":36},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"44ef91ba366547e5a217d675bcf10a77","type":"text","conversion_output":true,"text":"variable in subgroups defined by age ( \\(<65\\) vs. \\(\\geq 65\\) ), pre-treatment NIHSS score (0-2 vs. 3-5),","text_display":" variable in subgroups defined by age ( \\(<65\\) vs. \\(\\geq 65\\) ), pre-treatment NIHSS score (0-2 vs. 3-5),","confidence":0.5736631168634646,"confidence_rate":0.9947214762512073},{"cnt":[[443,681],[1656,681],[1656,715],[443,715]],"region":{"top_left_x":442,"top_left_y":681,"width":1215,"height":35},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8acb5889c6a84940ba0c34e4d4af781a","type":"text","conversion_output":true,"text":"last known well time to treatment ( \\(0-2\\) hours vs. \\(>2-3\\) hours), and stroke subgroups (rapidly","text_display":" last known well time to treatment ( \\(0-2\\) hours vs. \\(>2-3\\) hours), and stroke subgroups (rapidly","confidence":0.522982961456889,"confidence_rate":0.9937264951620642},{"cnt":[[443,713],[1257,713],[1257,750],[443,750]],"region":{"top_left_x":442,"top_left_y":713,"width":815,"height":37},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bde8507d919248a088e57f486d2c8007","type":"text","conversion_output":true,"text":"improving stroke symptoms [RISS] vs. non-RISS), respectively.","text_display":" improving stroke symptoms [RISS] vs. non-RISS), respectively.","confidence":1,"confidence_rate":1},{"cnt":[[443,791],[1033,791],[1033,827],[443,827]],"region":{"top_left_x":442,"top_left_y":790,"width":592,"height":38},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"355d8904f99a4acfba017883f5daf983","type":"text","conversion_output":true,"text":"The following endpoints will also be explored:","text_display":"\n\nThe following endpoints will also be explored:","confidence":0.99951171875,"confidence_rate":0.9999904235654993},{"cnt":[[449,834],[544,834],[544,866],[449,866]],"region":{"top_left_x":449,"top_left_y":833,"width":95,"height":33},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4275ab3ab55d4435b7910623ecc02064","type":"text","conversion_output":true,"text":"NIHSS","text_display":"\nNIHSS","confidence":1,"confidence_rate":1},{"cnt":[[451,877],[486,877],[486,911],[451,911]],"region":{"top_left_x":451,"top_left_y":876,"width":35,"height":35},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"645e2f010aa84aae8e5640205835970e","type":"text","conversion_output":true,"text":"BI","text_display":"\nBI","confidence":1,"confidence_rate":1},{"cnt":[[451,920],[520,920],[520,954],[451,954]],"region":{"top_left_x":451,"top_left_y":919,"width":69,"height":35},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e3145cde26be4b93a17f0a908bff0d94","type":"text","conversion_output":true,"text":"GOS","text_display":"\nGOS","confidence":1,"confidence_rate":1},{"cnt":[[449,965],[1214,965],[1214,999],[449,999]],"region":{"top_left_x":449,"top_left_y":964,"width":765,"height":36},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f2508206717b48f8915d1f1ff2e756d3","type":"text","conversion_output":true,"text":"Stroke recurrence (based on AE monitoring) within 90 days","text_display":"\nStroke recurrence (based on AE monitoring) within 90 days","confidence":0.99951171875,"confidence_rate":0.9999924861744118},{"cnt":[[449,1005],[1734,1005],[1734,1042],[449,1042]],"region":{"top_left_x":449,"top_left_y":1005,"width":1285,"height":37},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c80041fc027f41b08b729bacae10df92","type":"text","conversion_output":true,"text":"Cognition and behavior (modified 30 -minute battery: Controlled Oral Word Association test; Hopkins","text_display":"\nCognition and behavior (modified 30 -minute battery: Controlled Oral Word Association test; Hopkins","confidence":0.919062338070944,"confidence_rate":0.9992115135757131},{"cnt":[[494,1040],[1605,1040],[1605,1072],[494,1072]],"region":{"top_left_x":494,"top_left_y":1039,"width":1111,"height":34},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f741bcbb76a461183d9e9292ac30996","type":"text","conversion_output":true,"text":"Verbal Learning Test-Revised [HVLT-R] trials 1, 2, and 3; digit symbol coding from the","text_display":" Verbal Learning Test-Revised [HVLT-R] trials 1, 2, and 3; digit symbol coding from the","confidence":1,"confidence_rate":1},{"cnt":[[494,1070],[1712,1070],[1712,1106],[494,1106]],"region":{"top_left_x":494,"top_left_y":1069,"width":1219,"height":38},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0f76eef30a064f529119a110e4bd562b","type":"text","conversion_output":true,"text":"Wechsler Adult Intelligence Scale III [WAIS III]; Forward and Backward Digit Span test; Benton","text_display":" Wechsler Adult Intelligence Scale III [WAIS III]; Forward and Backward Digit Span test; Benton","confidence":1,"confidence_rate":1},{"cnt":[[494,1104],[1721,1104],[1721,1137],[494,1137]],"region":{"top_left_x":494,"top_left_y":1104,"width":1227,"height":33},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"19fe87e07d4f4cbc9c4fe46fbb723407","type":"text","conversion_output":true,"text":"Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency [Animal","text_display":" Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency [Animal","confidence":1,"confidence_rate":1},{"cnt":[[494,1134],[1476,1134],[1476,1171],[494,1171]],"region":{"top_left_x":494,"top_left_y":1134,"width":982,"height":37},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"67f5320d5efe40648af21d09f00fde18","type":"text","conversion_output":true,"text":"Naming test]; and Boston Naming Test [BNT; 15-item short form]) at Day 90","text_display":" Naming test]; and Boston Naming Test [BNT; 15-item short form]) at Day 90","confidence":0.9990234375,"confidence_rate":0.9999873112539076},{"cnt":[[447,1177],[1330,1177],[1330,1214],[447,1214]],"region":{"top_left_x":446,"top_left_y":1177,"width":884,"height":37},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"67c80d2d40724c39b85c6ed67256ed22","type":"text","conversion_output":true,"text":"Ambulatory performance (as measured by walking speed) at Day 90","text_display":"\nAmbulatory performance (as measured by walking speed) at Day 90","confidence":1,"confidence_rate":1},{"cnt":[[447,1220],[1149,1220],[1149,1257],[447,1257]],"region":{"top_left_x":446,"top_left_y":1220,"width":704,"height":37},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fbd12f4ab72744fbabebfe2e82335c40","type":"text","conversion_output":true,"text":"Center for Epidemiologic Studies-Depression (CES-D)","text_display":"\nCenter for Epidemiologic Studies-Depression (CES-D)","confidence":1,"confidence_rate":1},{"cnt":[[449,1263],[1386,1263],[1386,1300],[449,1300]],"region":{"top_left_x":449,"top_left_y":1263,"width":937,"height":37},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"564a33a94988466aa3516a3577cd19d9","type":"text","conversion_output":true,"text":"Quality of life (European Quality of Life [EQ-5D] questionnaire) at Day 90","text_display":"\nQuality of life (European Quality of Life [EQ-5D] questionnaire) at Day 90","confidence":1,"confidence_rate":1},{"cnt":[[447,1306],[1003,1306],[1003,1343],[447,1343]],"region":{"top_left_x":446,"top_left_y":1306,"width":558,"height":37},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"19ce0e381fab4a1fb3703c161997fd8c","type":"text","conversion_output":true,"text":"Stroke Impact Scale-16 (SIS-16) at Day 90","text_display":"\nStroke Impact Scale-16 (SIS-16) at Day 90","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[443,1384],[638,1384],[638,1424],[443,1424]],"region":{"top_left_x":442,"top_left_y":1383,"width":197,"height":42},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c433922ad7404ad4a2349f581f9c6abe","type":"section_header","conversion_output":false,"children_ids":["2e5e06f2b9a34ec4a487dd8f2a824bf2"],"text":"","text_display":""},{"cnt":[[443,1388],[638,1388],[638,1420],[443,1420]],"region":{"top_left_x":442,"top_left_y":1387,"width":197,"height":34},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2e5e06f2b9a34ec4a487dd8f2a824bf2","type":"text","conversion_output":true,"parent_id":"c433922ad7404ad4a2349f581f9c6abe","text":"Study Design","text_display":"\n\n\\section*{Study Design}","confidence":0.9990236759185791,"confidence_rate":0.9999425427685995},{"cnt":[[443,1427],[737,1427],[737,1467],[443,1467]],"region":{"top_left_x":442,"top_left_y":1426,"width":295,"height":42},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"acdd4a03fd8744378b82a63c37b256e7","type":"section_header","conversion_output":false,"children_ids":["ff1134255b124db599706df9d220ea39"],"text":"","text_display":""},{"cnt":[[443,1431],[733,1431],[733,1463],[443,1463]],"region":{"top_left_x":442,"top_left_y":1430,"width":291,"height":34},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ff1134255b124db599706df9d220ea39","type":"text","conversion_output":true,"parent_id":"acdd4a03fd8744378b82a63c37b256e7","text":"Description of Study","text_display":"\n\n\\section*{Description of Study}","confidence":1,"confidence_rate":1},{"cnt":[[443,1470],[1687,1470],[1687,1502],[443,1502]],"region":{"top_left_x":442,"top_left_y":1469,"width":1245,"height":33},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bc559bd014ce4cb4961165a7c66a0499","type":"text","conversion_output":true,"text":"PRISMS is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the efficacy and","text_display":"\n\nPRISMS is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the efficacy and","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[443,1500],[1729,1500],[1729,1532],[443,1532]],"region":{"top_left_x":442,"top_left_y":1499,"width":1288,"height":33},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d92880f015944588993db1c88fbf2970","type":"text","conversion_output":true,"text":"safety of IV alteplase in AIS patients with mild strokes that do not appear to be clearly disabling. The","text_display":" safety of IV alteplase in AIS patients with mild strokes that do not appear to be clearly disabling. The","confidence":1,"confidence_rate":1},{"cnt":[[443,1532],[1714,1532],[1714,1566],[443,1566]],"region":{"top_left_x":442,"top_left_y":1531,"width":1273,"height":36},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6bb95dbbb2c644db84ead755c6a61e87","type":"text","conversion_output":true,"text":"trial will consist of a screening assessment, randomization, and treatment followed by a Day 5 visit,","text_display":" trial will consist of a screening assessment, randomization, and treatment followed by a Day 5 visit,","confidence":1,"confidence_rate":1},{"cnt":[[443,1564],[1661,1564],[1661,1596],[443,1596]],"region":{"top_left_x":442,"top_left_y":1564,"width":1219,"height":33},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e6da789507614e58bf77dc72120d92ef","type":"text","conversion_output":true,"text":"30 -day phone call, and a 90-day follow-up visit. Treatment should start within 3 hours from last","text_display":" 30 -day phone call, and a 90-day follow-up visit. Treatment should start within 3 hours from last","confidence":0.8918344974517822,"confidence_rate":0.9988998872548271},{"cnt":[[443,1594],[973,1594],[973,1631],[443,1631]],"region":{"top_left_x":442,"top_left_y":1594,"width":532,"height":37},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d98de732b8854b9b87a46a7beefdc94a","type":"text","conversion_output":true,"text":"known well time (stroke symptom onset).","text_display":" known well time (stroke symptom onset).","confidence":1,"confidence_rate":1},{"cnt":[[443,1635],[1659,1635],[1659,1669],[443,1669]],"region":{"top_left_x":442,"top_left_y":1634,"width":1217,"height":36},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d33c537e23784b179bab4836079644df","type":"text","conversion_output":true,"text":"Screening assessments will be used to determine the eligibility of the patient. Patients meeting","text_display":"\nScreening assessments will be used to determine the eligibility of the patient. Patients meeting","confidence":1,"confidence_rate":1},{"cnt":[[443,1667],[1291,1667],[1291,1704],[443,1704]],"region":{"top_left_x":442,"top_left_y":1667,"width":850,"height":37},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"26d177a58092430491c2b03d504aefab","type":"text","conversion_output":true,"text":"eligibility criteria will be randomized in a \\(1: 1\\) ratio to receive either:","text_display":" eligibility criteria will be randomized in a \\(1: 1\\) ratio to receive either:","confidence":0.916015625,"confidence_rate":0.9989176003337045},{"cnt":[[443,1706],[1706,1706],[1706,1742],[443,1742]],"region":{"top_left_x":442,"top_left_y":1705,"width":1264,"height":38},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"fbd06733e6ea4be38fd91a3d7f25908c","type":"text","conversion_output":true,"text":"1. One dose of alteplase \\(0.9 mg / kg\\) IV (not to exceed 90 mg ) and one dose of oral aspirin placebo,","text_display":"\n1. One dose of alteplase \\(0.9 mg / kg\\) IV (not to exceed 90 mg ) and one dose of oral aspirin placebo,","confidence":0.44914960861206055,"confidence_rate":0.9931237568263368},{"cnt":[[443,1740],[498,1740],[498,1770],[443,1770]],"region":{"top_left_x":442,"top_left_y":1740,"width":57,"height":31},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f85a01ca312d45cbab45b183d013c5ef","type":"text","conversion_output":true,"text":"OR","text_display":" OR","confidence":1,"confidence_rate":1},{"cnt":[[443,1779],[1386,1779],[1386,1815],[443,1815]],"region":{"top_left_x":442,"top_left_y":1778,"width":944,"height":38},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"95c1b0dda6c64426a247d406dfbdaadc","type":"text","conversion_output":true,"text":"2. One dose of IV alteplase placebo and one dose of oral aspirin 325 mg .","text_display":"\n2. One dose of IV alteplase placebo and one dose of oral aspirin 325 mg .","confidence":0.99609375,"confidence_rate":0.9999528456982913},{"cnt":[[443,1818],[720,1818],[720,1858],[443,1858]],"region":{"top_left_x":442,"top_left_y":1817,"width":278,"height":42},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"70e122cd21be41d7b7767d0325786ded","type":"section_header","conversion_output":false,"children_ids":["3aeeb1cb88e4415a90ff0d2c6320d6c8"],"text":"","text_display":""},{"cnt":[[443,1822],[715,1822],[715,1854],[443,1854]],"region":{"top_left_x":442,"top_left_y":1821,"width":274,"height":34},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3aeeb1cb88e4415a90ff0d2c6320d6c8","type":"text","conversion_output":true,"parent_id":"70e122cd21be41d7b7767d0325786ded","text":"Number of Patients","text_display":"\n\n\\section*{Number of Patients}","confidence":1,"confidence_rate":1},{"cnt":[[443,1861],[1721,1861],[1721,1897],[443,1897]],"region":{"top_left_x":442,"top_left_y":1860,"width":1279,"height":38},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3fb6132a779146e58995a03778a14a08","type":"text","conversion_output":true,"text":"Approximately 948 patients with AIS and mild strokes will be enrolled in the study across 75 sites in","text_display":"\n\nApproximately 948 patients with AIS and mild strokes will be enrolled in the study across 75 sites in","confidence":1,"confidence_rate":1},{"cnt":[[443,1895],[642,1895],[642,1923],[443,1923]],"region":{"top_left_x":442,"top_left_y":1894,"width":201,"height":29},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bf00f2eb96454d86a9194eaba3f8d1d8","type":"text","conversion_output":true,"text":"North America.","text_display":" North America.","confidence":1,"confidence_rate":1},{"cnt":[[443,1934],[698,1934],[698,1974],[443,1974]],"region":{"top_left_x":442,"top_left_y":1933,"width":257,"height":42},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"38d783ea63244107a94c72926e5781f5","type":"section_header","conversion_output":false,"children_ids":["f505d41b34134ceea08c0b1953593a10"],"text":"","text_display":""},{"cnt":[[443,1934],[698,1934],[698,1970],[443,1970]],"region":{"top_left_x":442,"top_left_y":1933,"width":257,"height":38},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f505d41b34134ceea08c0b1953593a10","type":"text","conversion_output":true,"parent_id":"38d783ea63244107a94c72926e5781f5","text":"Target Population","text_display":"\n\n\\section*{Target Population}","confidence":1,"confidence_rate":1},{"cnt":[[443,1972],[672,1972],[672,2009],[443,2009]],"region":{"top_left_x":442,"top_left_y":1972,"width":231,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4ab786c585f047c48571600e8c4a6928","type":"section_header","conversion_output":false,"children_ids":["7da5638ff2994351a1558edacabfb3a3"],"text":"","text_display":""},{"cnt":[[443,1972],[668,1972],[668,2007],[443,2007]],"region":{"top_left_x":442,"top_left_y":1972,"width":227,"height":35},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7da5638ff2994351a1558edacabfb3a3","type":"text","conversion_output":true,"parent_id":"4ab786c585f047c48571600e8c4a6928","text":"Inclusion Criteria","text_display":"\n\n\\section*{Inclusion Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[443,2013],[1162,2013],[1162,2050],[443,2050]],"region":{"top_left_x":442,"top_left_y":2013,"width":721,"height":37},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ec8aa705d1ad4f33a03c9edcee2e919a","type":"text","conversion_output":true,"text":"Patients must meet the following criteria for study entry:","text_display":"\n\nPatients must meet the following criteria for study entry:","confidence":1,"confidence_rate":1},{"cnt":[[447,2054],[909,2054],[909,2090],[447,2090]],"region":{"top_left_x":446,"top_left_y":2053,"width":463,"height":38},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5a0f8f4cb4c44085a82eb4225622865c","type":"text","conversion_output":true,"text":"Age \\(\\geq 18\\) years (no upper age limit)","text_display":"\nAge \\(\\geq 18\\) years (no upper age limit)","confidence":1,"confidence_rate":1},{"cnt":[[447,2097],[1712,2097],[1712,2133],[447,2133]],"region":{"top_left_x":446,"top_left_y":2096,"width":1267,"height":38},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a5095aca044b478eae18b8ea84899a25","type":"text","conversion_output":true,"text":"Mild ischemic stroke defined as the most recent pre-treatment NIHSS score of \\(\\leq 5\\) and determined","text_display":"\nMild ischemic stroke defined as the most recent pre-treatment NIHSS score of \\(\\leq 5\\) and determined","confidence":0.9990234375,"confidence_rate":0.9999904212258001},{"cnt":[[494,2129],[1708,2129],[1708,2163],[494,2163]],"region":{"top_left_x":494,"top_left_y":2129,"width":1215,"height":35},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9a38b4533cc54f46b505ddaf79b0b74b","type":"text","conversion_output":true,"text":"as not clearly disabling by the investigator. This includes patients with persistently mild deficits","text_display":" as not clearly disabling by the investigator. This includes patients with persistently mild deficits","confidence":1,"confidence_rate":1},{"cnt":[[494,2161],[1635,2161],[1635,2198],[494,2198]],"region":{"top_left_x":494,"top_left_y":2161,"width":1141,"height":37},"line":50,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7bc7044a3a874d49b68b0c731af867e0","type":"text","conversion_output":true,"text":"as well as those who improve to a pre-treatment NIHSS score \\(\\leq 5\\) (also known as RISS).","text_display":" as well as those who improve to a pre-treatment NIHSS score \\(\\leq 5\\) (also known as RISS).","confidence":1,"confidence_rate":1},{"cnt":[[449,2204],[1674,2204],[1674,2241],[449,2241]],"region":{"top_left_x":449,"top_left_y":2204,"width":1225,"height":37},"line":51,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4f65a26bbb3242c5a3f3c737e6ff754b","type":"text","conversion_output":true,"text":"Study treatment can be initiated within 3 hours of last known well time without stroke symptoms","text_display":"\nStudy treatment can be initiated within 3 hours of last known well time without stroke symptoms","confidence":1,"confidence_rate":1},{"cnt":[[494,2239],[797,2239],[797,2271],[494,2271]],"region":{"top_left_x":494,"top_left_y":2238,"width":304,"height":33},"line":52,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"555d2364ff054fc99c9fa6f5472784fd","type":"text","conversion_output":true,"text":"(i.e., last seen normal).","text_display":" (i.e., last seen normal).","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1205,2333],[1205,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":773,"height":37},"line":53,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"42a4285c03224a4cb48112b49e2e141f","type":"section_header","conversion_output":false,"children_ids":["de005234cdd8409d9d36db2904aad5ea"],"text":"","text_display":""},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":54,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"de005234cdd8409d9d36db2904aad5ea","type":"text","conversion_output":true,"parent_id":"42a4285c03224a4cb48112b49e2e141f","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\n\\section*{Statistical Analysis Plan: Alteplase-Genentech USMA}","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[599,2368],[599,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":167,"height":33},"line":55,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9c34d0c24c874b18a22e569f1af16f2a","type":"text","conversion_output":true,"text":"35/ML29093","text_display":"\n\n35/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"505feff4c557416189c4570793b4ef7d","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":44},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b1b626b1827475c9ffe3d22bbf9f1f3","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.992689836657973,"confidence_rate":0.999887129239324},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90199cfbc5bf46f19bd00b526093c140","type":"page_info","conversion_output":false,"text":"796/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-37","page":37,"lines":[{"cnt":[[449,438],[1721,438],[1721,473],[449,473]],"region":{"top_left_x":449,"top_left_y":438,"width":1272,"height":35},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86d47577146d433d8c1548ed384b8c78","type":"text","conversion_output":true,"text":"Signed informed consent prior to initiation of any study-specific procedure or treatment. The patient","text_display":"\n\nSigned informed consent prior to initiation of any study-specific procedure or treatment. The patient","confidence":1,"confidence_rate":1},{"cnt":[[498,473],[1639,473],[1639,505],[498,505]],"region":{"top_left_x":498,"top_left_y":472,"width":1142,"height":33},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e97a0b475b4049968d5d1be69c7ea9d9","type":"text","conversion_output":true,"text":"or the patient's legally authorized representative must be able to provide written informed","text_display":" or the patient's legally authorized representative must be able to provide written informed","confidence":1,"confidence_rate":1},{"cnt":[[498,503],[1691,503],[1691,535],[498,535]],"region":{"top_left_x":498,"top_left_y":502,"width":1193,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b45ef51ad5154b15a8b748c485a1efba","type":"text","conversion_output":true,"text":"consent and understand the potential risks and benefits from study enrollment and treatment.","text_display":" consent and understand the potential risks and benefits from study enrollment and treatment.","confidence":1,"confidence_rate":1},{"cnt":[[443,569],[677,569],[677,604],[443,604]],"region":{"top_left_x":442,"top_left_y":569,"width":235,"height":35},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14055a54937f41b78a139c17a2c8d56d","type":"section_header","conversion_output":false,"children_ids":["25cc28c999c64723b9ce00bf8125e494"],"text":"","text_display":""},{"cnt":[[447,571],[677,571],[677,604],[447,604]],"region":{"top_left_x":446,"top_left_y":571,"width":231,"height":33},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25cc28c999c64723b9ce00bf8125e494","type":"text","conversion_output":true,"parent_id":"14055a54937f41b78a139c17a2c8d56d","text":"Exclusion Criteria","text_display":"\n\n\\section*{Exclusion Criteria}","confidence":1,"confidence_rate":1},{"cnt":[[447,612],[1472,612],[1472,647],[447,647]],"region":{"top_left_x":446,"top_left_y":612,"width":1026,"height":35},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae29a97e66234c5eb5cb2cedebbb3c7c","type":"text","conversion_output":true,"text":"Patients who meet any of the following criteria will be excluded from study entry:","text_display":"\n\nPatients who meet any of the following criteria will be excluded from study entry:","confidence":1,"confidence_rate":1},{"cnt":[[451,653],[1721,653],[1721,685],[451,685]],"region":{"top_left_x":451,"top_left_y":653,"width":1270,"height":33},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e46657a7e794738883a75d45a5fb09d","type":"text","conversion_output":true,"text":"Computed tomography (CT) or magnetic resonance imaging (MRI) findings consisting of one of the","text_display":"\nComputed tomography (CT) or magnetic resonance imaging (MRI) findings consisting of one of the","confidence":1,"confidence_rate":1},{"cnt":[[498,683],[621,683],[621,718],[498,718]],"region":{"top_left_x":498,"top_left_y":683,"width":123,"height":35},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b9a0a38e52b47d4b0087112968848a9","type":"text","conversion_output":true,"text":"following:","text_display":" following:","confidence":1,"confidence_rate":1},{"cnt":[[539,726],[1699,726],[1699,763],[539,763]],"region":{"top_left_x":539,"top_left_y":726,"width":1161,"height":37},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5717545af6364b009a035dd53676b41d","type":"text","conversion_output":true,"text":"CT with clear large hypodensity that is greater than one-third middle cerebral artery (MCA)","text_display":"\n\nCT with clear large hypodensity that is greater than one-third middle cerebral artery (MCA)","confidence":1,"confidence_rate":1},{"cnt":[[539,761],[1240,761],[1240,793],[539,793]],"region":{"top_left_x":539,"top_left_y":760,"width":701,"height":33},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bca2954c060742cc9cfe634a04adb722","type":"text","conversion_output":true,"text":"territory (or greater than 100 cc if not in MCA territory),","text_display":" territory (or greater than 100 cc if not in MCA territory),","confidence":1,"confidence_rate":1},{"cnt":[[541,799],[1618,799],[1618,831],[541,831]],"region":{"top_left_x":541,"top_left_y":799,"width":1077,"height":33},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1f43a785b25443aea482795b2717c889","type":"text","conversion_output":true,"text":"MRI with clear large hyperintensity on concurrent diffusion-weighted (DW) and fluid-","text_display":"\nMRI with clear large hyperintensity on concurrent diffusion-weighted (DW) and fluid","confidence":1,"confidence_rate":1},{"cnt":[[541,834],[1725,834],[1725,866],[541,866]],"region":{"top_left_x":541,"top_left_y":833,"width":1185,"height":33},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d55259a7e31f410bafe5e2920104b71b","type":"text","conversion_output":true,"text":"attenuated inversion recovery (FLAIR) that is greater than one-third MCA territory (or greater","text_display":"attenuated inversion recovery (FLAIR) that is greater than one-third MCA territory (or greater","confidence":1,"confidence_rate":1},{"cnt":[[541,864],[990,864],[990,896],[541,896]],"region":{"top_left_x":541,"top_left_y":863,"width":450,"height":33},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b2f626212c2418999953866a461fde2","type":"text","conversion_output":true,"text":"than 100 cc if not in MCA territory),","text_display":" than 100 cc if not in MCA territory),","confidence":1,"confidence_rate":1},{"cnt":[[541,904],[1416,904],[1416,939],[541,939]],"region":{"top_left_x":541,"top_left_y":904,"width":875,"height":35},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59fbd8f98f3c4adfab407ed138ee9281","type":"text","conversion_output":true,"text":"Imaging lesion consistent with acute hemorrhage of any degree, OR","text_display":"\nImaging lesion consistent with acute hemorrhage of any degree, OR","confidence":1,"confidence_rate":1},{"cnt":[[541,945],[1008,945],[1008,978],[541,978]],"region":{"top_left_x":541,"top_left_y":945,"width":467,"height":33},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54b77c87c1684cee9727610c3f74d405","type":"text","conversion_output":true,"text":"Evidence of intraparenchymal tumor","text_display":"\nEvidence of intraparenchymal tumor","confidence":1,"confidence_rate":1},{"cnt":[[451,984],[1287,984],[1287,1021],[451,1021]],"region":{"top_left_x":451,"top_left_y":983,"width":836,"height":38},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6853849a588d45009d35e2855bffb372","type":"text","conversion_output":true,"text":"Disability prior to the presenting stroke (historical mRS score \\(\\geq 2\\) )","text_display":"\nDisability prior to the presenting stroke (historical mRS score \\(\\geq 2\\) )","confidence":0.9263405799865723,"confidence_rate":0.9990673459851107},{"cnt":[[451,1027],[1667,1027],[1667,1061],[451,1061]],"region":{"top_left_x":451,"top_left_y":1026,"width":1217,"height":36},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"544aefa81a4e4d959c0915d6c576cca7","type":"text","conversion_output":true,"text":"Standard contraindications to IV alteplase for patients treated within 3 hours of symptom onset,","text_display":"\nStandard contraindications to IV alteplase for patients treated within 3 hours of symptom onset,","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[498,1061],[625,1061],[625,1094],[498,1094]],"region":{"top_left_x":498,"top_left_y":1061,"width":128,"height":33},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acedcb26862c4688b3c2fbcf8ebbd4ee","type":"text","conversion_output":true,"text":"including:","text_display":" including:","confidence":1,"confidence_rate":1},{"cnt":[[541,1104],[1326,1104],[1326,1137],[541,1137]],"region":{"top_left_x":541,"top_left_y":1104,"width":785,"height":33},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76fab372695340799075f40fa97de1ba","type":"text","conversion_output":true,"text":"Head trauma or previous stroke within the previous 3 months","text_display":"\n\nHead trauma or previous stroke within the previous 3 months","confidence":1,"confidence_rate":1},{"cnt":[[541,1143],[1184,1143],[1184,1175],[541,1175]],"region":{"top_left_x":541,"top_left_y":1142,"width":643,"height":34},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f024ee2ed284d5e84c227df8c0d4f43","type":"text","conversion_output":true,"text":"Myocardial infarction within the previous 3 months","text_display":"\nMyocardial infarction within the previous 3 months","confidence":1,"confidence_rate":1},{"cnt":[[541,1182],[1459,1182],[1459,1218],[541,1218]],"region":{"top_left_x":541,"top_left_y":1181,"width":918,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b999c8be8294a2ab22f8d34bde6be67","type":"text","conversion_output":true,"text":"Gastrointestinal or urinary tract hemorrhage within the previous 21 days","text_display":"\nGastrointestinal or urinary tract hemorrhage within the previous 21 days","confidence":1,"confidence_rate":1},{"cnt":[[541,1225],[1076,1225],[1076,1259],[541,1259]],"region":{"top_left_x":541,"top_left_y":1224,"width":536,"height":35},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"28a2aedf739a4a06b5812538baa64d2c","type":"text","conversion_output":true,"text":"Major surgery within the previous 14 days","text_display":"\nMajor surgery within the previous 14 days","confidence":1,"confidence_rate":1},{"cnt":[[539,1265],[1442,1265],[1442,1300],[539,1300]],"region":{"top_left_x":539,"top_left_y":1265,"width":903,"height":35},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba72e28d90304aa684894504952db628","type":"text","conversion_output":true,"text":"Arterial puncture at a non-compress ble site within the previous 7 days","text_display":"\nArterial puncture at a non-compress ble site within the previous 7 days","confidence":1,"confidence_rate":1},{"cnt":[[541,1306],[1463,1306],[1463,1338],[541,1338]],"region":{"top_left_x":541,"top_left_y":1306,"width":923,"height":33},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"320ed028b40948f3b2d04558404d0cd2","type":"text","conversion_output":true,"text":"Any history of ICH with the exception of < 5 chronic microbleeds on MRI","text_display":"\nAny history of ICH with the exception of < 5 chronic microbleeds on MRI","confidence":1,"confidence_rate":1},{"cnt":[[541,1345],[1669,1345],[1669,1379],[541,1379]],"region":{"top_left_x":541,"top_left_y":1344,"width":1129,"height":36},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42fa7b071cb644c59b07b527aa095941","type":"text","conversion_output":true,"text":"Elevated blood pressure (systolic \\(>185 mm Hg\\) or diastolic \\(>110 mm Hg\\) ), or the use of","text_display":"\nElevated blood pressure (systolic \\(>185 mm Hg\\) or diastolic \\(>110 mm Hg\\) ), or the use of","confidence":0.5835340649245592,"confidence_rate":0.9946279568237814},{"cnt":[[541,1379],[1708,1379],[1708,1412],[541,1412]],"region":{"top_left_x":541,"top_left_y":1379,"width":1168,"height":33},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b96e85914a674378a4af5285a3879ddd","type":"text","conversion_output":true,"text":"aggressive measures (use of more than two intravenous agents to lower blood pressure) to","text_display":" aggressive measures (use of more than two intravenous agents to lower blood pressure) to","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[541,1444],[541,1409],[1227,1412],[1227,1446]],"region":{"top_left_x":541,"top_left_y":1409,"width":686,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7788a7fe0524e5ca939a81a29ae997e","type":"text","conversion_output":true,"text":"achieve blood pressure within acceptable parameters","text_display":" achieve blood pressure within acceptable parameters","confidence":1,"confidence_rate":1},{"cnt":[[541,1452],[1601,1452],[1601,1485],[541,1485]],"region":{"top_left_x":541,"top_left_y":1452,"width":1060,"height":33},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"202bd05f668d44fabeabd15cded93246","type":"text","conversion_output":true,"text":"Treatment with unfractionated heparin within the last 48 hours and activated partial","text_display":"\nTreatment with unfractionated heparin within the last 48 hours and activated partial","confidence":1,"confidence_rate":1},{"cnt":[[541,1482],[1721,1482],[1721,1515],[541,1515]],"region":{"top_left_x":541,"top_left_y":1482,"width":1180,"height":33},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fef63118e0b94186bb78e260e158284f","type":"text","conversion_output":true,"text":"thromboplastin time outside of the normal range as specified by the center's local laboratory","text_display":" thromboplastin time outside of the normal range as specified by the center's local laboratory","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[541,1521],[879,1521],[879,1558],[541,1558]],"region":{"top_left_x":541,"top_left_y":1521,"width":338,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d6d3ef9bec64d8a98b22de8d6af5099","type":"text","conversion_output":true,"text":"Blood glucose \\(<50 mg / dL\\)","text_display":"\nBlood glucose \\(<50 mg / dL\\)","confidence":1,"confidence_rate":1},{"cnt":[[541,1564],[1601,1564],[1601,1596],[541,1596]],"region":{"top_left_x":541,"top_left_y":1564,"width":1060,"height":33},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d816ad62f2b74a1b82981099f3713298","type":"text","conversion_output":true,"text":"International normalized ratio > 1.7 (Note: This does not need to be verified prior to","text_display":"\nInternational normalized ratio > 1.7 (Note: This does not need to be verified prior to","confidence":0.9926886511966586,"confidence_rate":0.999921937007599},{"cnt":[[541,1594],[1321,1594],[1321,1631],[541,1631]],"region":{"top_left_x":541,"top_left_y":1594,"width":781,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3fa8ce69ee145e69b04ef0da33e5edb","type":"text","conversion_output":true,"text":"randomization if there is no clinical suspicion of abnormality.)","text_display":" randomization if there is no clinical suspicion of abnormality.)","confidence":1,"confidence_rate":1},{"cnt":[[541,1635],[1573,1635],[1573,1669],[541,1669]],"region":{"top_left_x":541,"top_left_y":1634,"width":1032,"height":36},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ddb9439103eb487889d6068c051b3467","type":"text","conversion_output":true,"text":"Platelet count of \\(<100,000 / mm 3\\) (Note: This does not need to be verified prior to","text_display":"\nPlatelet count of \\(<100,000 / mm 3\\) (Note: This does not need to be verified prior to","confidence":0.8452901840209961,"confidence_rate":0.9981547233287221},{"cnt":[[541,1667],[1321,1667],[1321,1704],[541,1704]],"region":{"top_left_x":541,"top_left_y":1667,"width":781,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad8306608da64f5097be3a25f98b5569","type":"text","conversion_output":true,"text":"randomization if there is no clinical suspicion of abnormality.)","text_display":" randomization if there is no clinical suspicion of abnormality.)","confidence":1,"confidence_rate":1},{"cnt":[[541,1706],[1601,1706],[1601,1740],[541,1740]],"region":{"top_left_x":541,"top_left_y":1705,"width":1060,"height":36},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6efa4056e054624829e8f00f0e7b64f","type":"text","conversion_output":true,"text":"Treatment with a direct thrombin inhibitor or factor Xa inh bitor (including novel oral","text_display":"\nTreatment with a direct thrombin inhibitor or factor Xa inh bitor (including novel oral","confidence":0.9770822525024414,"confidence_rate":0.999763452046807},{"cnt":[[541,1740],[1712,1740],[1712,1772],[541,1772]],"region":{"top_left_x":541,"top_left_y":1740,"width":1172,"height":33},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b71fc8e379647359891769c99f8f1ca","type":"text","conversion_output":true,"text":"anticoagulants [e.g., dabigatran, rivaroxaban, apixaban, edoxaban]) within the last 48 hours","text_display":" anticoagulants [e.g., dabigatran, rivaroxaban, apixaban, edoxaban]) within the last 48 hours","confidence":1,"confidence_rate":1},{"cnt":[[541,1779],[1706,1779],[1706,1815],[541,1815]],"region":{"top_left_x":541,"top_left_y":1778,"width":1165,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a0c3e629402e432caa1b3bc0d57e901a","type":"text","conversion_output":true,"text":"Treatment with a low-molecular-weight heparin (e.g., dalteparin, enoxaparin) within the last","text_display":" Treatment with a low-molecular-weight heparin (e.g., dalteparin, enoxaparin) within the last","confidence":1,"confidence_rate":1},{"cnt":[[541,1813],[655,1813],[655,1841],[541,1841]],"region":{"top_left_x":541,"top_left_y":1813,"width":115,"height":29},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27758412346d486d850d63a929cb910f","type":"text","conversion_output":true,"text":"48 hours","text_display":" 48 hours","confidence":1,"confidence_rate":1},{"cnt":[[451,1852],[1624,1852],[1624,1886],[451,1886]],"region":{"top_left_x":451,"top_left_y":1851,"width":1174,"height":36},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7b017afcf7f41afaa8814995458cdd0","type":"text","conversion_output":true,"text":"Allergic reactions to study drug or aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs)","text_display":"\nAllergic reactions to study drug or aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs)","confidence":1,"confidence_rate":1},{"cnt":[[451,1895],[1725,1895],[1725,1927],[451,1927]],"region":{"top_left_x":451,"top_left_y":1894,"width":1275,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"282cd1caa8614a859e021054c483998f","type":"text","conversion_output":true,"text":"Females of childbearing age who are known to be pregnant and/or lactating, or who have a positive","text_display":"\nFemales of childbearing age who are known to be pregnant and/or lactating, or who have a positive","confidence":1,"confidence_rate":1},{"cnt":[[498,1929],[870,1929],[870,1962],[498,1962]],"region":{"top_left_x":498,"top_left_y":1929,"width":373,"height":33},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"532d77a1e42e453fa73ac3bb0022550f","type":"text","conversion_output":true,"text":"pregnancy test on admission","text_display":" pregnancy test on admission","confidence":1,"confidence_rate":1},{"cnt":[[451,1972],[1555,1972],[1555,2004],[451,2004]],"region":{"top_left_x":451,"top_left_y":1972,"width":1105,"height":33},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e145163e208e4de2b1182ffe6f8cc79f","type":"text","conversion_output":true,"text":"Inability to swallow, which would prevent oral intake of aspirin or aspirin placebo tablet","text_display":"\nInability to swallow, which would prevent oral intake of aspirin or aspirin placebo tablet","confidence":1,"confidence_rate":1},{"cnt":[[451,2015],[1678,2015],[1678,2047],[451,2047]],"region":{"top_left_x":451,"top_left_y":2015,"width":1227,"height":33},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72429ad8a4114bc89e63161726b78561","type":"text","conversion_output":true,"text":"Other serious, advanced, or terminal illness that would confound the clinical outcome at 90 days","text_display":"\nOther serious, advanced, or terminal illness that would confound the clinical outcome at 90 days","confidence":1,"confidence_rate":1},{"cnt":[[451,2058],[1702,2058],[1702,2093],[451,2093]],"region":{"top_left_x":451,"top_left_y":2058,"width":1251,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77e9a7695a3441b09ad428edc37e542b","type":"text","conversion_output":true,"text":"Current or recent (within 3 months) participation in another investigational drug treatment protocol","text_display":"\nCurrent or recent (within 3 months) participation in another investigational drug treatment protocol","confidence":1,"confidence_rate":1},{"cnt":[[451,2101],[1235,2101],[1235,2133],[451,2133]],"region":{"top_left_x":451,"top_left_y":2101,"width":785,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad5c8c447d3a48b2bb12fd6471ba6547","type":"text","conversion_output":true,"text":"Anticipated inability to obtain 3-month follow-up assessments","text_display":"\nAnticipated inability to obtain 3-month follow-up assessments","confidence":0.53125,"confidence_rate":0.9904621019278371},{"cnt":[[451,2144],[862,2144],[862,2174],[451,2174]],"region":{"top_left_x":451,"top_left_y":2144,"width":411,"height":31},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02176d17b4ac4fd28efea040389d0380","type":"text","conversion_output":true,"text":"Previous enrollment in PRISMS","text_display":"\nPrevious enrollment in PRISMS","confidence":1,"confidence_rate":1},{"cnt":[[451,2187],[1644,2187],[1644,2221],[451,2221]],"region":{"top_left_x":451,"top_left_y":2187,"width":1193,"height":35},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e22ac200b266427987f07488f09e4b0e","type":"text","conversion_output":true,"text":"Any other condition that the investigator feels would pose a significant hazard to the patient if","text_display":"\nAny other condition that the investigator feels would pose a significant hazard to the patient if","confidence":1,"confidence_rate":1},{"cnt":[[496,2221],[947,2221],[947,2254],[496,2254]],"region":{"top_left_x":496,"top_left_y":2221,"width":452,"height":33},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15c8a56dc49346a89d2400258057daab","type":"text","conversion_output":true,"text":"treatment with alteplase is initiated","text_display":" treatment with alteplase is initiated","confidence":1,"confidence_rate":1},{"cnt":[[436,2333],[1201,2333],[1201,2370],[436,2370]],"region":{"top_left_x":436,"top_left_y":2333,"width":765,"height":37},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"877d3865c55146b2bf1b57a4f1e64f27","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[436,2368],[1182,2368],[1182,2400],[436,2400]],"region":{"top_left_x":436,"top_left_y":2367,"width":746,"height":33},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0b3b9a36c2f4722b5818b8ad4a07d73","type":"page_info","conversion_output":false,"text":"36/ML29093 5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[372,2574],[1416,2574],[1416,2615],[372,2615]],"region":{"top_left_x":371,"top_left_y":2573,"width":1045,"height":42},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b0a7a131c9d429599a0a52c0b1bae47","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936663979931382,"confidence_rate":0.9999022548641643},{"cnt":[[374,2608],[690,2608],[690,2640],[374,2640]],"region":{"top_left_x":373,"top_left_y":2608,"width":317,"height":33},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87096b8129614563a8782bc6139f8942","type":"page_info","conversion_output":false,"text":"797/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-38","page":38,"lines":[{"cnt":[[443,434],[675,434],[675,475],[443,475]],"region":{"top_left_x":442,"top_left_y":433,"width":233,"height":42},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"98e5d785af384f1ea987a32c76c230b1","type":"section_header","conversion_output":false,"children_ids":["65fa7709660c4618b271c4106d97158d"],"text":"","text_display":""},{"cnt":[[443,438],[672,438],[672,473],[443,473]],"region":{"top_left_x":442,"top_left_y":438,"width":231,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"65fa7709660c4618b271c4106d97158d","type":"text","conversion_output":true,"parent_id":"98e5d785af384f1ea987a32c76c230b1","text":"Length of Study","text_display":"\n\n\\section*{Length of Study}","confidence":1,"confidence_rate":1},{"cnt":[[443,473],[1661,473],[1661,509],[443,509]],"region":{"top_left_x":442,"top_left_y":472,"width":1219,"height":38},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d8e05bac4c2042a792b111b69d67b1b5","type":"text","conversion_output":true,"text":"Based on study enrollment projections, this study is estimated to take approximately 4 years to","text_display":"\n\nBased on study enrollment projections, this study is estimated to take approximately 4 years to","confidence":1,"confidence_rate":1},{"cnt":[[443,507],[1710,507],[1710,544],[443,544]],"region":{"top_left_x":442,"top_left_y":507,"width":1269,"height":37},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f27a15e557f04aca8f950bd9e8aa9e51","type":"text","conversion_output":true,"text":"complete, from first patient in to last patient's last visit (LPLV), when the final patient completes the","text_display":" complete, from first patient in to last patient's last visit (LPLV), when the final patient completes the","confidence":1,"confidence_rate":1},{"cnt":[[443,541],[672,541],[672,574],[443,574]],"region":{"top_left_x":442,"top_left_y":541,"width":231,"height":33},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"22b319ad19ce4b28bf3c7a91067eb9b3","type":"text","conversion_output":true,"text":"90-day follow-up.","text_display":" 90-day follow-up.","confidence":1,"confidence_rate":1},{"cnt":[[443,578],[634,578],[634,621],[443,621]],"region":{"top_left_x":442,"top_left_y":577,"width":192,"height":44},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f0cc74154d4842718ac5f9acc476ddb3","type":"section_header","conversion_output":false,"children_ids":["c38b596b8e4d496784aac4c3fb61102a"],"text":"","text_display":""},{"cnt":[[443,580],[629,580],[629,617],[443,617]],"region":{"top_left_x":442,"top_left_y":580,"width":188,"height":37},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c38b596b8e4d496784aac4c3fb61102a","type":"text","conversion_output":true,"parent_id":"f0cc74154d4842718ac5f9acc476ddb3","text":"End of Study","text_display":"\n\n\\section*{End of Study}","confidence":1,"confidence_rate":1},{"cnt":[[443,619],[1708,619],[1708,655],[443,655]],"region":{"top_left_x":442,"top_left_y":618,"width":1267,"height":38},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"107d6e8f4fa84667998f98f314d7abf0","type":"text","conversion_output":true,"text":"The end of the study is defined as the date when the LPLV occurs. The LPLV is expected to occur","text_display":"\n\nThe end of the study is defined as the date when the LPLV occurs. The LPLV is expected to occur","confidence":1,"confidence_rate":1},{"cnt":[[443,653],[1480,653],[1480,690],[443,690]],"region":{"top_left_x":442,"top_left_y":653,"width":1039,"height":37},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d9f77d56b706487492458485c294282c","type":"text","conversion_output":true,"text":"approximately 90 days ( \\(\\pm 14\\) days) after the last patient is enrolled into the study.","text_display":" approximately 90 days ( \\(\\pm 14\\) days) after the last patient is enrolled into the study.","confidence":0.9868285626871511,"confidence_rate":0.9998604418445364},{"cnt":[[440,696],[844,696],[844,741],[440,741]],"region":{"top_left_x":440,"top_left_y":696,"width":405,"height":46},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8b59ca8b98d5411e95ed8b940e26ac53","type":"section_header","conversion_output":false,"children_ids":["2caa1aa540c0421498975178a687a423"],"text":"","text_display":""},{"cnt":[[443,700],[840,700],[840,737],[443,737]],"region":{"top_left_x":442,"top_left_y":700,"width":399,"height":37},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2caa1aa540c0421498975178a687a423","type":"text","conversion_output":true,"parent_id":"8b59ca8b98d5411e95ed8b940e26ac53","text":"Efficacy Outcome Measures","text_display":"\n\n\\section*{Efficacy Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[443,739],[1158,739],[1158,776],[443,776]],"region":{"top_left_x":442,"top_left_y":739,"width":717,"height":37},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4fe3330459db405b8d90ee5d0b061aef","type":"text","conversion_output":true,"text":"The primary efficacy outcome measure for this study is:","text_display":"\n\nThe primary efficacy outcome measure for this study is:","confidence":1,"confidence_rate":1},{"cnt":[[447,778],[1695,778],[1695,814],[447,814]],"region":{"top_left_x":446,"top_left_y":777,"width":1250,"height":38},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1ffe548d640e40b3998526dc3125b0da","type":"text","conversion_output":true,"text":"A favorable functional outcome, defined by an mRS score of 0 or 1 at Day 90 post-randomization","text_display":"\nA favorable functional outcome, defined by an mRS score of 0 or 1 at Day 90 post-randomization","confidence":0.9951171875,"confidence_rate":0.9999570643219667},{"cnt":[[537,821],[1687,821],[1687,857],[537,857]],"region":{"top_left_x":537,"top_left_y":820,"width":1150,"height":38},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"451a55ebc7e846e1b57f621159a092e8","type":"text","conversion_output":true,"text":"All mRS assessments will be made by investigators blinded to treatment assignment who","text_display":" All mRS assessments will be made by investigators blinded to treatment assignment who","confidence":0.95703125,"confidence_rate":0.9995426126133627},{"cnt":[[537,855],[1141,855],[1141,887],[537,887]],"region":{"top_left_x":537,"top_left_y":855,"width":604,"height":33},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dd0db30ba963496f86880e371b11f859","type":"text","conversion_output":true,"text":"are trained and certified in mRS administration","text_display":" are trained and certified in mRS administration","confidence":0.62255859375,"confidence_rate":0.9909276061559915},{"cnt":[[443,932],[1124,932],[1124,971],[443,971]],"region":{"top_left_x":442,"top_left_y":932,"width":682,"height":40},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"46b15af58b104fc7b06b8a96590ccb5c","type":"text","conversion_output":true,"text":"The secondary efficacy outcomes at Day 90 include:","text_display":"\n\nThe secondary efficacy outcomes at Day 90 include:","confidence":1,"confidence_rate":1},{"cnt":[[447,975],[621,975],[621,1008],[447,1008]],"region":{"top_left_x":446,"top_left_y":975,"width":175,"height":33},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"afeddc90ce034141b34a89f2df359b87","type":"text","conversion_output":true,"text":"Ordinal mRS","text_display":"\nOrdinal mRS","confidence":0.99462890625,"confidence_rate":0.999663458522005},{"cnt":[[447,1018],[1687,1018],[1687,1055],[447,1055]],"region":{"top_left_x":446,"top_left_y":1018,"width":1241,"height":37},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7524f2783e5a44a68159c957c9832866","type":"text","conversion_output":true,"text":"Global favorable recovery (Global Outcome Measure derived from mRS 0-1, NIHSS 0-1, BI \\(\\geq 95\\),","text_display":"\nGlobal favorable recovery (Global Outcome Measure derived from mRS 0-1, NIHSS 0-1, BI \\(\\geq 95\\),","confidence":0.9936668711110287,"confidence_rate":0.9999358276326217},{"cnt":[[494,1053],[660,1053],[660,1087],[494,1087]],"region":{"top_left_x":494,"top_left_y":1052,"width":166,"height":36},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"933bdf33c5324304b6da6bca19e43032","type":"text","conversion_output":true,"text":"and GOS 1)","text_display":" and GOS 1)","confidence":1,"confidence_rate":1},{"cnt":[[438,1126],[819,1126],[819,1167],[438,1167]],"region":{"top_left_x":438,"top_left_y":1125,"width":381,"height":42},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2e415a60264f4c2594e00836609347c6","type":"section_header","conversion_output":false,"children_ids":["88404580f7a341d6984b118be34d6c4b"],"text":"","text_display":""},{"cnt":[[443,1130],[814,1130],[814,1162],[443,1162]],"region":{"top_left_x":442,"top_left_y":1130,"width":373,"height":33},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"88404580f7a341d6984b118be34d6c4b","type":"text","conversion_output":true,"parent_id":"2e415a60264f4c2594e00836609347c6","text":"Safety Outcome Measures","text_display":"\n\n\\section*{Safety Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[443,1164],[1205,1164],[1205,1205],[443,1205]],"region":{"top_left_x":442,"top_left_y":1164,"width":764,"height":42},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e5dcd916221b40bd808fdaec461d37f6","type":"text","conversion_output":true,"text":"The safety outcome measures for this study are as follows:","text_display":"\n\nThe safety outcome measures for this study are as follows:","confidence":1,"confidence_rate":1},{"cnt":[[447,1207],[1261,1207],[1261,1244],[447,1244]],"region":{"top_left_x":446,"top_left_y":1207,"width":816,"height":37},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"699abf7f61ad499e945fd3c4755e3ec9","type":"text","conversion_output":true,"text":"Incidence of sICH within 36 hours (primary safety assessment)","text_display":"\nIncidence of sICH within 36 hours (primary safety assessment)","confidence":0.98876953125,"confidence_rate":0.9998363321397015},{"cnt":[[537,1250],[1687,1250],[1687,1287],[537,1287]],"region":{"top_left_x":537,"top_left_y":1250,"width":1150,"height":37},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f1de02ac1c484d58a0f2de00cf211c3a","type":"text","conversion_output":true,"text":"sICH is defined as any neurological decline attr buted to new ICH seen on imaging by the","text_display":"\nsICH is defined as any neurological decline attr buted to new ICH seen on imaging by the","confidence":1,"confidence_rate":1},{"cnt":[[537,1283],[1687,1283],[1687,1317],[537,1317]],"region":{"top_left_x":537,"top_left_y":1282,"width":1150,"height":35},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"59ac5fc4f8ce4a7b9eafede6929e8666","type":"text","conversion_output":true,"text":"investigator. New ICH seen on imaging will be later confirmed on independent reading by","text_display":" investigator. New ICH seen on imaging will be later confirmed on independent reading by","confidence":1,"confidence_rate":1},{"cnt":[[537,1315],[973,1315],[973,1351],[537,1351]],"region":{"top_left_x":537,"top_left_y":1314,"width":437,"height":38},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f35c244b44654bdf982b6d284e609a5d","type":"text","conversion_output":true,"text":"blinded central study radiologists.","text_display":" blinded central study radiologists.","confidence":1,"confidence_rate":1},{"cnt":[[447,1354],[767,1354],[767,1390],[447,1390]],"region":{"top_left_x":446,"top_left_y":1353,"width":321,"height":38},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"36ef7207650e458cafc4cebcafdf41f7","type":"text","conversion_output":true,"text":"Any ICH within 36 hours","text_display":"\nAny ICH within 36 hours","confidence":1,"confidence_rate":1},{"cnt":[[447,1396],[857,1396],[857,1433],[447,1433]],"region":{"top_left_x":446,"top_left_y":1396,"width":412,"height":38},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8c8fbe6632d244ee88facff28f4d7d32","type":"text","conversion_output":true,"text":"Overall mortality within 90 days","text_display":"\nOverall mortality within 90 days","confidence":0.99951171875,"confidence_rate":0.9999877900620892},{"cnt":[[447,1439],[1145,1439],[1145,1480],[447,1480]],"region":{"top_left_x":446,"top_left_y":1439,"width":700,"height":42},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b2e895da6f4e402a9f77115d53fa8481","type":"text","conversion_output":true,"text":"Stroke-related and neurological deaths within 90 days","text_display":"\nStroke-related and neurological deaths within 90 days","confidence":1,"confidence_rate":1},{"cnt":[[447,1482],[1154,1482],[1154,1521],[447,1521]],"region":{"top_left_x":446,"top_left_y":1482,"width":708,"height":40},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"eb5edb9aa9864ce9abb1fba87a3be085","type":"text","conversion_output":true,"text":"Incidence, severity, and spectrum of all AEs and SAEs","text_display":"\nIncidence, severity, and spectrum of all AEs and SAEs","confidence":1,"confidence_rate":1},{"cnt":[[440,1560],[932,1560],[932,1601],[440,1601]],"region":{"top_left_x":440,"top_left_y":1559,"width":493,"height":42},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"09786e187abd4bacaede8412423e30d5","type":"section_header","conversion_output":false,"children_ids":["1b9f2101b96547cdba7a7a27a18197bf"],"text":"","text_display":""},{"cnt":[[443,1562],[930,1562],[930,1601],[443,1601]],"region":{"top_left_x":442,"top_left_y":1561,"width":489,"height":40},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1b9f2101b96547cdba7a7a27a18197bf","type":"text","conversion_output":true,"parent_id":"09786e187abd4bacaede8412423e30d5","text":"Investigational Medicinal Products","text_display":"\n\n\\section*{Investigational Medicinal Products}","confidence":1,"confidence_rate":1},{"cnt":[[443,1603],[937,1603],[937,1644],[443,1644]],"region":{"top_left_x":442,"top_left_y":1602,"width":495,"height":42},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"78f622380d804beeaee419027b38c84e","type":"section_header","conversion_output":false,"children_ids":["ebf3e69aecd54d52a62760ba29ac651c"],"text":"","text_display":""},{"cnt":[[443,1607],[935,1607],[935,1644],[443,1644]],"region":{"top_left_x":442,"top_left_y":1607,"width":493,"height":37},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ebf3e69aecd54d52a62760ba29ac651c","type":"text","conversion_output":true,"parent_id":"78f622380d804beeaee419027b38c84e","text":"Test Product (Investigational Drug)","text_display":"\n\n\\section*{Test Product (Investigational Drug)}","confidence":1,"confidence_rate":1},{"cnt":[[443,1641],[1605,1641],[1605,1680],[443,1680]],"region":{"top_left_x":442,"top_left_y":1641,"width":1163,"height":40},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"551f3517184f467bb7ed00d172ef7e0a","type":"text","conversion_output":true,"text":"Patients randomized to the active arm will receive treatment with \\(0.9 mg / kg\\) of IV alteplase","text_display":"\n\nPatients randomized to the active arm will receive treatment with \\(0.9 mg / kg\\) of IV alteplase","confidence":1,"confidence_rate":1},{"cnt":[[443,1676],[1042,1676],[1042,1712],[443,1712]],"region":{"top_left_x":442,"top_left_y":1675,"width":600,"height":38},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b9353314482b48d7848ee31218275cc6","type":"text","conversion_output":true,"text":"(maximum 90 mg ) per standard stroke dosing.","text_display":" (maximum 90 mg ) per standard stroke dosing.","confidence":1,"confidence_rate":1},{"cnt":[[443,1714],[621,1714],[621,1755],[443,1755]],"region":{"top_left_x":442,"top_left_y":1714,"width":179,"height":42},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cdd619a5ebd5401b9836b1cf9dc2eb08","type":"section_header","conversion_output":false,"children_ids":["c34d269cd73f4f26a41eda9ef6e5a5d7"],"text":"","text_display":""},{"cnt":[[443,1719],[617,1719],[617,1755],[443,1755]],"region":{"top_left_x":442,"top_left_y":1718,"width":175,"height":38},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c34d269cd73f4f26a41eda9ef6e5a5d7","type":"text","conversion_output":true,"parent_id":"cdd619a5ebd5401b9836b1cf9dc2eb08","text":"Comparator","text_display":"\n\n\\section*{Comparator}","confidence":1,"confidence_rate":1},{"cnt":[[443,1755],[1656,1755],[1656,1794],[443,1794]],"region":{"top_left_x":442,"top_left_y":1755,"width":1215,"height":39},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c3e6509caced4544b4e627253528f4ce","type":"text","conversion_output":true,"text":"Patients randomized to the placebo arm will receive IV alteplase placebo consisting of 1.7 g of","text_display":"\n\nPatients randomized to the placebo arm will receive IV alteplase placebo consisting of 1.7 g of","confidence":0.9970703125,"confidence_rate":0.9999720576529205},{"cnt":[[443,1788],[1278,1788],[1278,1824],[443,1824]],"region":{"top_left_x":442,"top_left_y":1787,"width":837,"height":38},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"50967292f0024bfe92a260269fbfdb2b","type":"text","conversion_output":true,"text":"L-arginine, 5 mg of polysorbate 80, and 0.5 g of phosphoric acid.","text_display":" L-arginine, 5 mg of polysorbate 80, and 0.5 g of phosphoric acid.","confidence":0.6187494099140167,"confidence_rate":0.9940172816760704},{"cnt":[[440,1833],[999,1833],[999,1876],[440,1876]],"region":{"top_left_x":440,"top_left_y":1832,"width":560,"height":44},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f08ad4c3f1bd4be2b14b3944b1ad88a8","type":"section_header","conversion_output":false,"children_ids":["97f6c86f8fae4d8e894e71b81a5e5d1a"],"text":"","text_display":""},{"cnt":[[443,1835],[995,1835],[995,1871],[443,1871]],"region":{"top_left_x":442,"top_left_y":1834,"width":553,"height":38},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"97f6c86f8fae4d8e894e71b81a5e5d1a","type":"text","conversion_output":true,"parent_id":"f08ad4c3f1bd4be2b14b3944b1ad88a8","text":"Non-Investigational Medicinal Products","text_display":"\n\n\\section*{Non-Investigational Medicinal Products}","confidence":1,"confidence_rate":1},{"cnt":[[443,1878],[621,1878],[621,1919],[443,1919]],"region":{"top_left_x":442,"top_left_y":1877,"width":179,"height":42},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7d3ce1fddac04f60aa62e5df7ea0b7a5","type":"section_header","conversion_output":false,"children_ids":["cd858ce9d54746e3a12182072f0f67f7"],"text":"","text_display":""},{"cnt":[[443,1882],[617,1882],[617,1919],[443,1919]],"region":{"top_left_x":442,"top_left_y":1882,"width":175,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"cd858ce9d54746e3a12182072f0f67f7","type":"text","conversion_output":true,"parent_id":"7d3ce1fddac04f60aa62e5df7ea0b7a5","text":"Comparator","text_display":"\n\n\\section*{Comparator}","confidence":1,"confidence_rate":1},{"cnt":[[443,1919],[1729,1919],[1729,1953],[443,1953]],"region":{"top_left_x":442,"top_left_y":1918,"width":1288,"height":35},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"20afc4f89c68471aa43a47bc0b1888e7","type":"text","conversion_output":true,"text":"To maintain standard medical care, patients randomized to the IV alteplase placebo arm will receive","text_display":"\n\nTo maintain standard medical care, patients randomized to the IV alteplase placebo arm will receive","confidence":1,"confidence_rate":1},{"cnt":[[443,1951],[1450,1951],[1450,1987],[443,1987]],"region":{"top_left_x":442,"top_left_y":1950,"width":1009,"height":38},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9dd023d82242483a84f7b6725c5c9886","type":"text","conversion_output":true,"text":"325 mg of oral aspirin at the same time that they receive IV alteplase placebo.","text_display":" 325 mg of oral aspirin at the same time that they receive IV alteplase placebo.","confidence":1,"confidence_rate":1},{"cnt":[[440,1989],[621,1989],[621,2032],[440,2032]],"region":{"top_left_x":440,"top_left_y":1989,"width":181,"height":44},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e18ba03aa7c34493ab8bffe2a628e394","type":"section_header","conversion_output":false,"children_ids":["585f21ecf11b411ea7e868a38a54fea3"],"text":"","text_display":""},{"cnt":[[443,1994],[617,1994],[617,2030],[443,2030]],"region":{"top_left_x":442,"top_left_y":1993,"width":175,"height":38},"line":48,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"585f21ecf11b411ea7e868a38a54fea3","type":"text","conversion_output":true,"parent_id":"e18ba03aa7c34493ab8bffe2a628e394","text":"Comparator","text_display":"\n\n\\section*{Comparator}","confidence":1,"confidence_rate":1},{"cnt":[[443,2030],[1687,2030],[1687,2065],[443,2065]],"region":{"top_left_x":442,"top_left_y":2030,"width":1245,"height":35},"line":49,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1ac851766cdd4cffaa92cddb4ead12e1","type":"text","conversion_output":true,"text":"Patients in the IV alteplase active arm will receive an oral aspirin placebo tablet at the same time","text_display":"\n\nPatients in the IV alteplase active arm will receive an oral aspirin placebo tablet at the same time","confidence":0.99853515625,"confidence_rate":0.9999860389766703},{"cnt":[[443,2062],[1695,2062],[1695,2099],[443,2099]],"region":{"top_left_x":442,"top_left_y":2062,"width":1254,"height":38},"line":50,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c59c965916dd40029754e412101bde43","type":"text","conversion_output":true,"text":"they receive IV alteplase. The placebo will be identical in appearance to active aspirin to maintain","text_display":" they receive IV alteplase. The placebo will be identical in appearance to active aspirin to maintain","confidence":1,"confidence_rate":1},{"cnt":[[443,2093],[690,2093],[690,2133],[443,2133]],"region":{"top_left_x":442,"top_left_y":2092,"width":248,"height":42},"line":51,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"58d97a8e2ce8499da8d369a1a436455e","type":"text","conversion_output":true,"text":"treatment blinding.","text_display":" treatment blinding.","confidence":1,"confidence_rate":1},{"cnt":[[443,2140],[720,2140],[720,2181],[443,2181]],"region":{"top_left_x":442,"top_left_y":2139,"width":278,"height":42},"line":52,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d05872fff8744e4f849290af7109c6c9","type":"section_header","conversion_output":false,"children_ids":["38be0eb5ef55470b9fbefe865cd4ae84"],"text":"","text_display":""},{"cnt":[[443,2144],[715,2144],[715,2176],[443,2176]],"region":{"top_left_x":442,"top_left_y":2144,"width":274,"height":33},"line":53,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"38be0eb5ef55470b9fbefe865cd4ae84","type":"text","conversion_output":true,"parent_id":"d05872fff8744e4f849290af7109c6c9","text":"Statistical Methods","text_display":"\n\n\\section*{Statistical Methods}","confidence":1,"confidence_rate":1},{"cnt":[[443,2183],[690,2183],[690,2228],[443,2228]],"region":{"top_left_x":442,"top_left_y":2182,"width":248,"height":46},"line":54,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0aed3a1dd7e345f198c830a6802b6096","type":"section_header","conversion_output":false,"children_ids":["b4ea2a607e7d45e3a04ce05fbb39648e"],"text":"","text_display":""},{"cnt":[[443,2187],[685,2187],[685,2224],[443,2224]],"region":{"top_left_x":442,"top_left_y":2187,"width":244,"height":37},"line":55,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b4ea2a607e7d45e3a04ce05fbb39648e","type":"text","conversion_output":true,"parent_id":"0aed3a1dd7e345f198c830a6802b6096","text":"Primary Analysis","text_display":"\n\n\\section*{Primary Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[443,2224],[1656,2224],[1656,2262],[443,2262]],"region":{"top_left_x":442,"top_left_y":2223,"width":1215,"height":40},"line":56,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2c8120d5aa744f26afe4297e0db9b1dc","type":"text","conversion_output":true,"text":"The primary efficacy analysis will test the hypothesis of superiority of IV alteplase therapy over","text_display":"\n\nThe primary efficacy analysis will test the hypothesis of superiority of IV alteplase therapy over","confidence":1,"confidence_rate":1},{"cnt":[[443,2256],[1624,2256],[1624,2292],[443,2292]],"region":{"top_left_x":442,"top_left_y":2255,"width":1183,"height":38},"line":57,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a8a63fe309d442e2a3a4f73bb7d1ce3d","type":"text","conversion_output":true,"text":"standard medical care in AIS patients with mild deficits. The primary efficacy outcome is the","text_display":" standard medical care in AIS patients with mild deficits. The primary efficacy outcome is the","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1205,2333],[1205,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":773,"height":37},"line":58,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"78b985934e3447a1804b32125593f26b","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[434,2368],[604,2368],[604,2402],[434,2402]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":35},"line":59,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b0da3abaf1484841bffd571397a7ac8d","type":"text","conversion_output":true,"text":"37/ML29093","text_display":"\n37/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":60,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c4fb7aad37db4df9a4ed479cc1f27472","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2617],[370,2617]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":44},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5087201a2735419a92f61e22280d756d","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9931769268624175,"confidence_rate":0.9998946754435268},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea8bff12d6c642bd8770b25a6637e189","type":"page_info","conversion_output":false,"text":"798/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-39","page":39,"lines":[{"cnt":[[443,438],[1682,438],[1682,473],[443,473]],"region":{"top_left_x":442,"top_left_y":438,"width":1241,"height":35},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4ec5cb647c244cc08dc962e0b10a9451","type":"text","conversion_output":true,"text":"proportion of patients with a favorable outcome, defined by mRS score of 0 or 1 at 90 days post-","text_display":"\nproportion of patients with a favorable outcome, defined by mRS score of 0 or 1 at 90 days post","confidence":0.67236328125,"confidence_rate":0.9965838098164643},{"cnt":[[443,471],[1704,471],[1704,505],[443,505]],"region":{"top_left_x":442,"top_left_y":470,"width":1262,"height":35},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a9b2eeee67934af191d0c3ad82011423","type":"text","conversion_output":true,"text":"randomization. The difference in the proportion of mRS 0-1 responders (favorable outcome) at 90","text_display":"randomization. The difference in the proportion of mRS 0-1 responders (favorable outcome) at 90","confidence":0.7778245843724108,"confidence_rate":0.9976099630764692},{"cnt":[[443,503],[1693,503],[1693,535],[443,535]],"region":{"top_left_x":442,"top_left_y":502,"width":1251,"height":33},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d7c99009ccfd48c5bc3d9929cc03f465","type":"text","conversion_output":true,"text":"days post-randomization between the IV alteplase arm and the standard medical care arm will be","text_display":" days post-randomization between the IV alteplase arm and the standard medical care arm will be","confidence":1,"confidence_rate":1},{"cnt":[[443,533],[1721,533],[1721,569],[443,569]],"region":{"top_left_x":442,"top_left_y":532,"width":1279,"height":38},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2190da0005914d9782784a5c854584ab","type":"text","conversion_output":true,"text":"compared via a Cochran-Mantel-Haenszel test, stratified by pre-treatment NIHSS score ( \\(0-2\\) vs. 3","text_display":" compared via a Cochran-Mantel-Haenszel test, stratified by pre-treatment NIHSS score ( \\(0-2\\) vs. 3","confidence":0.975204898044467,"confidence_rate":0.9997562658417583},{"cnt":[[443,563],[1706,563],[1706,599],[443,599]],"region":{"top_left_x":442,"top_left_y":562,"width":1264,"height":38},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"675f59d9d1b44a0c91046d42be61dea3","type":"text","conversion_output":true,"text":"-5 ), age ( \\(<65\\) vs. \\(\\geq 65\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(>2-3\\) hours). The","text_display":" -5 ), age ( \\(<65\\) vs. \\(\\geq 65\\) ), and last known well time to treatment ( \\(0-2\\) hours vs. \\(>2-3\\) hours). The","confidence":0.8840687527285118,"confidence_rate":0.9989101479065844},{"cnt":[[443,597],[1725,597],[1725,632],[443,632]],"region":{"top_left_x":442,"top_left_y":597,"width":1284,"height":35},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b3768376ad1d45dd8f10a2faf1daff80","type":"text","conversion_output":true,"text":"primary efficacy analysis will include all randomized patients, with patients grouped according to the","text_display":" primary efficacy analysis will include all randomized patients, with patients grouped according to the","confidence":1,"confidence_rate":1},{"cnt":[[443,629],[1695,629],[1695,664],[443,664]],"region":{"top_left_x":442,"top_left_y":629,"width":1254,"height":35},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"625888ce157d45ddb32c683f982f8969","type":"text","conversion_output":true,"text":"treatment assigned at randomization adhering to the intent-to-treat (ITT) principle. As a sensitivity","text_display":" treatment assigned at randomization adhering to the intent-to-treat (ITT) principle. As a sensitivity","confidence":1,"confidence_rate":1},{"cnt":[[443,662],[1532,662],[1532,694],[443,694]],"region":{"top_left_x":442,"top_left_y":661,"width":1090,"height":33},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1ff41698f6af4eacb3da765ad77403d5","type":"text","conversion_output":true,"text":"analysis, results from the univariate Pearson's chi-square test will also be presented.","text_display":" analysis, results from the univariate Pearson's chi-square test will also be presented.","confidence":1,"confidence_rate":1},{"cnt":[[443,700],[862,700],[862,741],[443,741]],"region":{"top_left_x":442,"top_left_y":700,"width":420,"height":42},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f92a9ca2c79d457cbca27e6b1059d370","type":"section_header","conversion_output":false,"children_ids":["1e92ab369a944b1fa111baa66e6c4aba"],"text":"","text_display":""},{"cnt":[[443,705],[857,705],[857,737],[443,737]],"region":{"top_left_x":442,"top_left_y":704,"width":416,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1e92ab369a944b1fa111baa66e6c4aba","type":"text","conversion_output":true,"parent_id":"f92a9ca2c79d457cbca27e6b1059d370","text":"Determination of Sample Size","text_display":"\n\n\\section*{Determination of Sample Size}","confidence":1,"confidence_rate":1},{"cnt":[[443,739],[1725,739],[1725,776],[443,776]],"region":{"top_left_x":442,"top_left_y":739,"width":1284,"height":37},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ee3b12d1ceee43d28adad58da3d38718","type":"text","conversion_output":true,"text":"A sample size of 856 is required in order to achieve \\(80 \\%\\) power for the primary analysis to detect an","text_display":"\n\nA sample size of 856 is required in order to achieve \\(80 \\%\\) power for the primary analysis to detect an","confidence":1,"confidence_rate":1},{"cnt":[[443,773],[1712,773],[1712,808],[443,808]],"region":{"top_left_x":442,"top_left_y":773,"width":1271,"height":35},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"000b7694c3ea4557b8d119a63d4efc01","type":"text","conversion_output":true,"text":"effect size of \\(9 \\%\\) absolute difference in the proportion of patients with favorable outcomes between","text_display":" effect size of \\(9 \\%\\) absolute difference in the proportion of patients with favorable outcomes between","confidence":0.9990234375,"confidence_rate":0.9999908688300274},{"cnt":[[443,804],[1712,804],[1712,840],[443,840]],"region":{"top_left_x":442,"top_left_y":803,"width":1271,"height":38},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"90d8bc32a005472fb1bba91250dac511","type":"text","conversion_output":true,"text":"the alteplase and control arms. The above sample size calculation assumes a control proportion of","text_display":" the alteplase and control arms. The above sample size calculation assumes a control proportion of","confidence":1,"confidence_rate":1},{"cnt":[[443,838],[1717,838],[1717,870],[443,870]],"region":{"top_left_x":442,"top_left_y":837,"width":1275,"height":34},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1952cde0783b45e495625da9f989ea38","type":"text","conversion_output":true,"text":"\\(65 \\%\\) and Type I error probability of 0.025 (one-sided), and uses a group sequential design with one","text_display":" \\(65 \\%\\) and Type I error probability of 0.025 (one-sided), and uses a group sequential design with one","confidence":0.9921910762786865,"confidence_rate":0.9999253401869048},{"cnt":[[443,868],[1695,868],[1695,904],[443,904]],"region":{"top_left_x":442,"top_left_y":867,"width":1254,"height":38},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"396b7837c81e40acbd46e629dfad4087","type":"text","conversion_output":true,"text":"interim analysis for futility (non-binding), based on an O'Brien-Fleming boundary, after \\(50 \\%\\) of the","text_display":" interim analysis for futility (non-binding), based on an O'Brien-Fleming boundary, after \\(50 \\%\\) of the","confidence":0.97265625,"confidence_rate":0.9997409256401869},{"cnt":[[445,902],[1687,902],[1687,935],[445,935]],"region":{"top_left_x":444,"top_left_y":902,"width":1243,"height":33},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"85c796736b714f5c87abbd456434d05e","type":"text","conversion_output":true,"text":"anticipated sample size have completed the 90-day follow-up assessments. was used in","text_display":" anticipated sample size have completed the 90-day follow-up assessments. was used in","confidence":1,"confidence_rate":1},{"cnt":[[443,932],[754,932],[754,967],[443,967]],"region":{"top_left_x":442,"top_left_y":932,"width":313,"height":35},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"788e7773b0634d58b3ead5fad32ef1d0","type":"text","conversion_output":true,"text":"sample size calculation.","text_display":" sample size calculation.","confidence":1,"confidence_rate":1},{"cnt":[[443,971],[1721,971],[1721,1008],[443,1008]],"region":{"top_left_x":442,"top_left_y":971,"width":1279,"height":37},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1a6ec9321e1b4f309f49d4f0970791a4","type":"text","conversion_output":true,"text":"The ITT principle will be applied to the primary analysis and, therefore, to safeguard against dilution","text_display":"\nThe ITT principle will be applied to the primary analysis and, therefore, to safeguard against dilution","confidence":1,"confidence_rate":1},{"cnt":[[443,1005],[1732,1005],[1732,1038],[443,1038]],"region":{"top_left_x":442,"top_left_y":1005,"width":1290,"height":33},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1b1716acedb54c66ae5c01d50de42a2a","type":"text","conversion_output":true,"text":"of the treatment effect associated with an approximate \\(5 \\%\\) non-adherence rate (due to lost to follow-","text_display":" of the treatment effect associated with an approximate \\(5 \\%\\) non-adherence rate (due to lost to follow","confidence":1,"confidence_rate":1},{"cnt":[[443,1036],[1695,1036],[1695,1070],[443,1070]],"region":{"top_left_x":442,"top_left_y":1035,"width":1254,"height":35},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a172f9fcc25440fca7fbc5bae0065df3","type":"text","conversion_output":true,"text":"up, consent withdrawal, treatment crossovers, and stroke mimics), the above sample needs to be","text_display":"up, consent withdrawal, treatment crossovers, and stroke mimics), the above sample needs to be","confidence":1,"confidence_rate":1},{"cnt":[[443,1068],[1717,1068],[1717,1102],[443,1102]],"region":{"top_left_x":442,"top_left_y":1067,"width":1275,"height":36},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f9c4d7fbf77046248116da5eac58e890","type":"text","conversion_output":true,"text":"inflated by a factor of 1/0.952 or 1.108 (Friedman et al. 1998). Therefore, a total sample size of 948","text_display":" inflated by a factor of 1/0.952 or 1.108 (Friedman et al. 1998). Therefore, a total sample size of 948","confidence":0.5987069426337257,"confidence_rate":0.9953047906520033},{"cnt":[[443,1100],[763,1100],[763,1137],[443,1137]],"region":{"top_left_x":442,"top_left_y":1100,"width":321,"height":37},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6c297239a3384f9a9e6181552ac3797c","type":"text","conversion_output":true,"text":"is required for this study.","text_display":" is required for this study.","confidence":1,"confidence_rate":1},{"cnt":[[443,1139],[677,1139],[677,1179],[443,1179]],"region":{"top_left_x":442,"top_left_y":1138,"width":235,"height":42},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"82518a18f9764398aea36e3149f05a87","type":"section_header","conversion_output":false,"children_ids":["dfaad6d6bfcd4d7aab2848a092f4dea4"],"text":"","text_display":""},{"cnt":[[443,1143],[672,1143],[672,1179],[443,1179]],"region":{"top_left_x":442,"top_left_y":1142,"width":231,"height":38},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dfaad6d6bfcd4d7aab2848a092f4dea4","type":"text","conversion_output":true,"parent_id":"82518a18f9764398aea36e3149f05a87","text":"Interim Analysis","text_display":"\n\n\\section*{Interim Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[443,1182],[1607,1182],[1607,1216],[443,1216]],"region":{"top_left_x":442,"top_left_y":1181,"width":1166,"height":36},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6fc857ea083c4b09baf75fcd257ab7c2","type":"text","conversion_output":true,"text":"One interim analysis of the primary efficacy outcome is planned for clear futility, conducted","text_display":"\n\nOne interim analysis of the primary efficacy outcome is planned for clear futility, conducted","confidence":1,"confidence_rate":1},{"cnt":[[443,1212],[1682,1212],[1682,1248],[443,1248]],"region":{"top_left_x":442,"top_left_y":1211,"width":1241,"height":38},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b9f48c957e96433089d1f65cf1b26afc","type":"text","conversion_output":true,"text":"according to the beta-spending approach (Pampallona et al. 2001) with an O'Brien-Fleming-type","text_display":" according to the beta-spending approach (Pampallona et al. 2001) with an O'Brien-Fleming-type","confidence":1,"confidence_rate":1},{"cnt":[[443,1246],[1605,1246],[1605,1278],[443,1278]],"region":{"top_left_x":442,"top_left_y":1246,"width":1163,"height":33},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f2c2b9dde4ca4334aa0acca5568d6345","type":"text","conversion_output":true,"text":"boundary. This futility analysis will occur after approximately 50\\% of patients (or 474) have","text_display":" boundary. This futility analysis will occur after approximately 50\\% of patients (or 474) have","confidence":0.66552734375,"confidence_rate":0.9958537668618312},{"cnt":[[443,1276],[900,1276],[900,1313],[443,1313]],"region":{"top_left_x":442,"top_left_y":1276,"width":459,"height":37},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"09684fec113a45b5857e074b0aa946ae","type":"text","conversion_output":true,"text":"completed the 90-day assessment.","text_display":" completed the 90-day assessment.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a340b9e84288444ba0af9b8299651428","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999912786005654},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3c6f5b67f72c4c66a2b28eea607a8f89","type":"page_info","conversion_output":false,"text":"38/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a74769ca26be46829783911d457dcfe9","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d63ddc81930845a1bc12f418769dc676","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9951250501919731,"confidence_rate":0.9999248201932889},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2eeb67a26cf246c2b35f485f47bfac68","type":"page_info","conversion_output":false,"text":"799/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-40","page":40,"lines":[{"cnt":[[969,432],[1783,432],[1783,537],[969,537]],"region":{"top_left_x":968,"top_left_y":431,"width":816,"height":107},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47b93c7741144e3abc1d0c09929b4739","type":"section_header","conversion_output":false,"children_ids":["1ab45ecfba6640739baa736faaec8971","26e93fc1d5e94560ae72ded1bc4214a6"],"text":"","text_display":""},{"cnt":[[1272,443],[1476,443],[1476,483],[1272,483]],"region":{"top_left_x":1271,"top_left_y":442,"width":205,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1ab45ecfba6640739baa736faaec8971","type":"text","conversion_output":true,"parent_id":"47b93c7741144e3abc1d0c09929b4739","text":"Appendix B","text_display":"\n\n\\section*{Appendix B","confidence":1,"confidence_rate":1},{"cnt":[[980,483],[1772,483],[1772,526],[980,526]],"region":{"top_left_x":979,"top_left_y":483,"width":794,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26e93fc1d5e94560ae72ded1bc4214a6","type":"text","conversion_output":true,"parent_id":"47b93c7741144e3abc1d0c09929b4739","text":"Schedule of Assessment and Study Flow Chart","text_display":" \\\\ Schedule of Assessment and Study Flow Chart}","confidence":1,"confidence_rate":1},{"cnt":[[417,578],[2333,578],[2333,1714],[417,1714]],"region":{"top_left_x":416,"top_left_y":577,"width":1918,"height":1138},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14e87a5f2e67440cb8eeb14e8d671713","type":"table","conversion_output":true,"children_ids":["2b56a409afc548aca54d70e71bae17dd","a9ed113a2e114c4da6d951a34db4bb44","b0b14c3b62e643629c690626822edd36","9c8f49ab51fc445bb96274558f590652","3a016f31a58b4424ac4910bcacf6307b","5d18496c267f4860b813773b695e9514","48d0c750342145a69a950446832ecab8","d350f1ebf0574dc59575024d06d2bbca","35966903203b498aa75867d51b022d4d","33858f34d52340aea34228ba6483a09f","cbcce291825a4cd5aa1b960b9913ea8c","84407eac17ed4b4aae42d8f19d01b2c1","d22a7324a5f140ad950ba5e9f630fefb","f3ade1e858804bbabc04b70e77cbec7b","885cc79c26b34b7e97b17f9cdb565c30","8ff0307ed93349e6803104727f4a02c7","3333de88504d4727a60edcc68d36c0ad","9b91acc0d42e48338aa206a234b59a91","c57ea7d2b10a49b08d5eb613eb63c2bb","e010398486b34c289a7dd4f7f8a309d9","e8ff4790ba3a4c18842b99958e309880","29aac5e2b3754dd7bb89a5e24bdeaf79","2242eed5b50542e497ee38f21ce74ea2","255dda9475e144c9a52b98694fdcbfad","ebb630ce136e4b818e05d5c0327e7103","5b28fee096214817a02f2ff2e84a3d8f","02c05d65fdf046ee820131d1a81dfb7c","95682b2510d04b7abb01e938f76b1e09","3f578625829046aa88672cf1655173fa","ceb179720f954cdc9dbb82ffb3350671","d45e8d69d78f4e28b13aaccf8bd59b7f","af8a8cadf54f4a1491e47d930f84dbd8","b9a8e33448104a0891597749584e67b0","a1a73fee2fc145138b2533985b8fb467","42ca79207508495cb2d46d74520312ea","b15ca1495256409d987bff433e5cf759","97473000cf2e4bf3a61b311194d2e2f7","3615f92344444e7c86181e22d0bcd9c9","8198f3039f824826876ba2a016a37a94","789b2926157a40cb85fd301642c6ecc7","6998bac330904f9299dce1493c741ee4","301d70260cb24435aff647e0f6ea2bb8","ba8a5d4ed90c4811b4283e62b34a2538","059e82aa2b754d8a9d6438c6399c90d0","fbe1dddf1e5b472fbf1fab4b1baf986c","70041c555fc5442492231b72ee2df2fb","d93ac425dccd4b9b9305ef4296a4e6ec","bdf87d8d222e44e5bc6497a7e9e618ef","6b073a9f78734403a94896464984c2d6","6083142558904896a07336b82c0e290a","d2fbcdf3618b47fdaa16097f353a5355","4d1c5e0611434929a6afd9e1f8c278ee","ac74e58f47eb4a1d83f2fe07e0c4bf22","7858b14729844c979a6932ef6321b32e","0b208505e0dc475cae3dfe6d638db9ab","bb250680e4a644398ad0a665e680639f","cbccbedde5ce4d00983ea224581464ad","b3f9211e688346bcaea84fccbccd62e6","befaf439753947efbdc69e967f067b1e","b9ea7304222b47099e456c6abff26a73"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4) & 90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5) & Early Discontinuation (Phone call if possible) \\\\\n\\hline Informed consent & X & & & & & & \\\\\n\\hline Review of elig bility & X & & & & & & \\\\\n\\hline Medical history and baseline conditions \\({ }^{\\text {a }}\\) & X & & & & & & \\\\\n\\hline Demographics & X & & & & & & \\\\\n\\hline Physical examination \\({ }^{\\text {b }}\\) & X & & & & & & \\\\\n\\hline Vital signs \\({ }^{\\text {c }}\\) & X & & & & & & \\\\\n\\hline Complete blood count \\({ }^{\\text {d }}\\) & X & & & & & & \\\\\n\\hline Coagulation status \\({ }^{\\text {e }}\\) & X & & & & & & \\\\\n\\hline Pregnancy test \\({ }^{ f }\\) & X & & & & & & \\\\\n\\hline Serum blood glucose \\({ }^{\\text {g }}\\) & X & & & & & & \\\\\n\\hline Imaging modality sensitive to presence of intracranial hemorrhage (either CT or MRI with DW MRI, either SW or GRE, and FLAIR images). Visit 2 MRIs should also include T1 and T2 sequences & X & & X & & & & \\\\\n\\hline NIHSS score \\({ }^{i}\\) & X & & X & X & & X & \\\\\n\\hline Study drug administration & & X & & & & & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4) & 90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5) & Early Discontinuation (Phone call if possible) \\\\\n\\hline Informed consent & X & & & & & & \\\\\n\\hline Review of elig bility & X & & & & & & \\\\\n\\hline Medical history and baseline conditions \\({ }^{\\text {a }}\\) & X & & & & & & \\\\\n\\hline Demographics & X & & & & & & \\\\\n\\hline Physical examination \\({ }^{\\text {b }}\\) & X & & & & & & \\\\\n\\hline Vital signs \\({ }^{\\text {c }}\\) & X & & & & & & \\\\\n\\hline Complete blood count \\({ }^{\\text {d }}\\) & X & & & & & & \\\\\n\\hline Coagulation status \\({ }^{\\text {e }}\\) & X & & & & & & \\\\\n\\hline Pregnancy test \\({ }^{ f }\\) & X & & & & & & \\\\\n\\hline Serum blood glucose \\({ }^{\\text {g }}\\) & X & & & & & & \\\\\n\\hline Imaging modality sensitive to presence of intracranial hemorrhage (either CT or MRI with DW MRI, either SW or GRE, and FLAIR images). Visit 2 MRIs should also include T1 and T2 sequences & X & & X & & & & \\\\\n\\hline NIHSS score \\({ }^{i}\\) & X & & X & X & & X & \\\\\n\\hline Study drug administration & & X & & & & & \\\\\n\\hline\n\\end{tabular}","confidence":0.5087890625,"confidence_rate":0.9981904626751354},{"cnt":[[425,577],[840,577],[840,1716],[425,1716]],"region":{"top_left_x":424,"top_left_y":577,"width":417,"height":1140},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b56a409afc548aca54d70e71bae17dd","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[840,577],[1046,577],[1046,1716],[840,1716]],"region":{"top_left_x":840,"top_left_y":577,"width":207,"height":1140},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9ed113a2e114c4da6d951a34db4bb44","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[1048,577],[1243,577],[1243,1716],[1048,1716]],"region":{"top_left_x":1048,"top_left_y":577,"width":196,"height":1140},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b0b14c3b62e643629c690626822edd36","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[1252,577],[1449,577],[1449,1716],[1252,1716]],"region":{"top_left_x":1251,"top_left_y":577,"width":198,"height":1140},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c8f49ab51fc445bb96274558f590652","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[1460,577],[1652,577],[1652,1716],[1460,1716]],"region":{"top_left_x":1459,"top_left_y":577,"width":194,"height":1140},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a016f31a58b4424ac4910bcacf6307b","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[1674,577],[1843,577],[1845,1716],[1676,1716]],"region":{"top_left_x":1673,"top_left_y":576,"width":173,"height":1141},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d18496c267f4860b813773b695e9514","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[1884,577],[2068,577],[2068,1716],[1884,1716]],"region":{"top_left_x":1884,"top_left_y":577,"width":185,"height":1140},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48d0c750342145a69a950446832ecab8","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[2099,577],[2317,577],[2317,1716],[2099,1716]],"region":{"top_left_x":2098,"top_left_y":577,"width":220,"height":1140},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d350f1ebf0574dc59575024d06d2bbca","type":"table_column","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,586],[2335,586],[2335,813],[416,813]],"region":{"top_left_x":416,"top_left_y":585,"width":1919,"height":229},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35966903203b498aa75867d51b022d4d","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,822],[2335,822],[2335,861],[416,861]],"region":{"top_left_x":416,"top_left_y":821,"width":1919,"height":40},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33858f34d52340aea34228ba6483a09f","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,874],[2335,874],[2335,915],[416,915]],"region":{"top_left_x":416,"top_left_y":873,"width":1919,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbcce291825a4cd5aa1b960b9913ea8c","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,923],[2335,923],[2335,997],[416,997]],"region":{"top_left_x":416,"top_left_y":923,"width":1919,"height":75},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84407eac17ed4b4aae42d8f19d01b2c1","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1010],[2335,1010],[2335,1051],[416,1051]],"region":{"top_left_x":416,"top_left_y":1010,"width":1919,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d22a7324a5f140ad950ba5e9f630fefb","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1056],[2335,1056],[2335,1101],[416,1101]],"region":{"top_left_x":416,"top_left_y":1055,"width":1919,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3ade1e858804bbabc04b70e77cbec7b","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1108],[2335,1108],[2335,1151],[416,1151]],"region":{"top_left_x":416,"top_left_y":1107,"width":1919,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"885cc79c26b34b7e97b17f9cdb565c30","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1155],[2335,1155],[2335,1203],[416,1203]],"region":{"top_left_x":416,"top_left_y":1155,"width":1919,"height":48},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ff0307ed93349e6803104727f4a02c7","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1209],[2335,1209],[2335,1255],[416,1255]],"region":{"top_left_x":416,"top_left_y":1209,"width":1919,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3333de88504d4727a60edcc68d36c0ad","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1257],[2335,1257],[2335,1307],[416,1307]],"region":{"top_left_x":416,"top_left_y":1256,"width":1919,"height":51},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b91acc0d42e48338aa206a234b59a91","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1311],[2335,1311],[2335,1354],[416,1354]],"region":{"top_left_x":416,"top_left_y":1311,"width":1919,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c57ea7d2b10a49b08d5eb613eb63c2bb","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1361],[2335,1361],[2335,1614],[416,1614]],"region":{"top_left_x":416,"top_left_y":1360,"width":1919,"height":255},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e010398486b34c289a7dd4f7f8a309d9","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1612],[2335,1612],[2335,1653],[416,1653]],"region":{"top_left_x":416,"top_left_y":1612,"width":1919,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8ff4790ba3a4c18842b99958e309880","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[416,1664],[2335,1664],[2335,1710],[416,1710]],"region":{"top_left_x":416,"top_left_y":1664,"width":1919,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"29aac5e2b3754dd7bb89a5e24bdeaf79","type":"table_row","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"","text_display":""},{"cnt":[[511,683],[752,683],[752,713],[511,713]],"region":{"top_left_x":511,"top_left_y":683,"width":241,"height":31},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2242eed5b50542e497ee38f21ce74ea2","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"ASSESSMENTS","text_display":"ASSESSMENTS","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999694754347522},{"cnt":[[844,648],[1042,646],[1043,755],[845,758]],"region":{"top_left_x":843,"top_left_y":646,"width":201,"height":112},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"255dda9475e144c9a52b98694fdcbfad","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["39e287e37d754cf1b2babb5eae8ce69f","a6971ffdc7954898aa6b3a9012f18245","d5400b42af0148e8845455f6b39cc6b0"],"text":"Screening and Baseline (Visit 1)","text_display":"Screening and Baseline (Visit 1)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[849,651],[1037,651],[1037,683],[849,683]],"region":{"top_left_x":849,"top_left_y":650,"width":189,"height":34},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39e287e37d754cf1b2babb5eae8ce69f","type":"text","conversion_output":false,"parent_id":"255dda9475e144c9a52b98694fdcbfad","text":"Screening and","text_display":"Screening and","confidence":1,"confidence_rate":1},{"cnt":[[888,685],[1003,685],[1003,713],[888,713]],"region":{"top_left_x":888,"top_left_y":685,"width":115,"height":29},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6971ffdc7954898aa6b3a9012f18245","type":"text","conversion_output":false,"parent_id":"255dda9475e144c9a52b98694fdcbfad","text":"Baseline","text_display":" Baseline","confidence":1,"confidence_rate":1},{"cnt":[[892,720],[994,720],[994,752],[892,752]],"region":{"top_left_x":892,"top_left_y":719,"width":103,"height":34},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d5400b42af0148e8845455f6b39cc6b0","type":"text","conversion_output":false,"parent_id":"255dda9475e144c9a52b98694fdcbfad","text":"(Visit 1)","text_display":" (Visit 1)","confidence":1,"confidence_rate":1},{"cnt":[[1053,664],[1243,664],[1243,735],[1053,735]],"region":{"top_left_x":1052,"top_left_y":663,"width":192,"height":73},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ebb630ce136e4b818e05d5c0327e7103","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["6bc3cfe357d14e88ac5b6d3450ab09a2","d52afb10fd7b415180b5e76b966da1f4"],"text":"Study Drug Administration","text_display":"Study Drug Administration","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1070,668],[1222,668],[1222,700],[1070,700]],"region":{"top_left_x":1069,"top_left_y":667,"width":153,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bc3cfe357d14e88ac5b6d3450ab09a2","type":"text","conversion_output":false,"parent_id":"ebb630ce136e4b818e05d5c0327e7103","text":"Study Drug","text_display":"Study Drug","confidence":1,"confidence_rate":1},{"cnt":[[1053,703],[1241,703],[1241,731],[1053,731]],"region":{"top_left_x":1052,"top_left_y":702,"width":190,"height":29},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d52afb10fd7b415180b5e76b966da1f4","type":"text","conversion_output":false,"parent_id":"ebb630ce136e4b818e05d5c0327e7103","text":"Administration","text_display":" Administration","confidence":1,"confidence_rate":1},{"cnt":[[1252,596],[1449,596],[1449,809],[1252,809]],"region":{"top_left_x":1251,"top_left_y":596,"width":198,"height":213},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b28fee096214817a02f2ff2e84a3d8f","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["b61868cfe8a54d838f5b1b9b72539581","a6e77c565b304058812eed9f9f7f0c7c","a7896e2ac3004cbdaa785dc841f28320","2f16b4d87c204e4482cd3718757efcb2","32a285185c9e45faa24ae2a976591e2e","e76dace9a750461b8686d41ef41ea938"],"text":"22-36 Hours from Start of Study Drug Administration (Visit 2)","text_display":"22-36 Hours from Start of Study Drug Administration (Visit 2)","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1308,599],[1395,599],[1395,629],[1308,629]],"region":{"top_left_x":1308,"top_left_y":598,"width":87,"height":31},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b61868cfe8a54d838f5b1b9b72539581","type":"text","conversion_output":false,"parent_id":"5b28fee096214817a02f2ff2e84a3d8f","text":"22-36","text_display":"22-36","confidence":1,"confidence_rate":1},{"cnt":[[1274,633],[1423,633],[1423,661],[1274,661]],"region":{"top_left_x":1273,"top_left_y":633,"width":150,"height":29},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a6e77c565b304058812eed9f9f7f0c7c","type":"text","conversion_output":false,"parent_id":"5b28fee096214817a02f2ff2e84a3d8f","text":"Hours from","text_display":" Hours from","confidence":1,"confidence_rate":1},{"cnt":[[1295,668],[1406,668],[1406,696],[1295,696]],"region":{"top_left_x":1295,"top_left_y":667,"width":111,"height":30},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7896e2ac3004cbdaa785dc841f28320","type":"text","conversion_output":false,"parent_id":"5b28fee096214817a02f2ff2e84a3d8f","text":"Start of","text_display":" Start of","confidence":1,"confidence_rate":1},{"cnt":[[1278,703],[1425,703],[1425,735],[1278,735]],"region":{"top_left_x":1277,"top_left_y":702,"width":149,"height":34},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f16b4d87c204e4482cd3718757efcb2","type":"text","conversion_output":false,"parent_id":"5b28fee096214817a02f2ff2e84a3d8f","text":"Study Drug","text_display":" Study Drug","confidence":1,"confidence_rate":1},{"cnt":[[1256,737],[1445,737],[1445,765],[1256,765]],"region":{"top_left_x":1256,"top_left_y":737,"width":189,"height":29},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"32a285185c9e45faa24ae2a976591e2e","type":"text","conversion_output":false,"parent_id":"5b28fee096214817a02f2ff2e84a3d8f","text":"Administration","text_display":" Administration","confidence":1,"confidence_rate":1},{"cnt":[[1300,772],[1401,772],[1401,804],[1300,804]],"region":{"top_left_x":1299,"top_left_y":771,"width":103,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e76dace9a750461b8686d41ef41ea938","type":"text","conversion_output":false,"parent_id":"5b28fee096214817a02f2ff2e84a3d8f","text":"(Visit 2)","text_display":" (Visit 2)","confidence":1,"confidence_rate":1},{"cnt":[[1462,631],[1648,631],[1648,772],[1462,772]],"region":{"top_left_x":1461,"top_left_y":631,"width":188,"height":141},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02c05d65fdf046ee820131d1a81dfb7c","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["77f25779c2b74d199fc93d359b5b5320","39a06ce025494dbe8298a3742d876509","c1966b67b16b42b9a90353d4a0fbe5b3","23fb7548b0ce45b785359bc2394dd397"],"text":"Day 5 (or Discharge if Sooner) (Visit 3)","text_display":"Day 5 (or Discharge if Sooner) (Visit 3)","cell_row":0,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999864300969632},{"cnt":[[1516,633],[1598,633],[1598,668],[1516,668]],"region":{"top_left_x":1516,"top_left_y":633,"width":83,"height":35},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77f25779c2b74d199fc93d359b5b5320","type":"text","conversion_output":false,"parent_id":"02c05d65fdf046ee820131d1a81dfb7c","text":"Day 5","text_display":"Day 5","confidence":1,"confidence_rate":1},{"cnt":[[1464,668],[1648,668],[1648,700],[1464,700]],"region":{"top_left_x":1464,"top_left_y":667,"width":185,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39a06ce025494dbe8298a3742d876509","type":"text","conversion_output":false,"parent_id":"02c05d65fdf046ee820131d1a81dfb7c","text":"(or Discharge","text_display":" (or Discharge","confidence":0.9990234375,"confidence_rate":0.9999457214926967},{"cnt":[[1486,703],[1622,703],[1622,735],[1486,735]],"region":{"top_left_x":1485,"top_left_y":702,"width":138,"height":34},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1966b67b16b42b9a90353d4a0fbe5b3","type":"text","conversion_output":false,"parent_id":"02c05d65fdf046ee820131d1a81dfb7c","text":"if Sooner)","text_display":" if Sooner)","confidence":1,"confidence_rate":1},{"cnt":[[1503,737],[1609,737],[1609,770],[1503,770]],"region":{"top_left_x":1503,"top_left_y":737,"width":107,"height":33},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23fb7548b0ce45b785359bc2394dd397","type":"text","conversion_output":false,"parent_id":"02c05d65fdf046ee820131d1a81dfb7c","text":"(Visit 3)","text_display":" (Visit 3)","confidence":1,"confidence_rate":1},{"cnt":[[1676,631],[1839,631],[1839,774],[1676,774]],"region":{"top_left_x":1676,"top_left_y":631,"width":163,"height":144},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95682b2510d04b7abb01e938f76b1e09","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["260928d0a59e45a6ac60e685731ab706","c0244b9d13d0461aa0ca75044f002b5e","4e8824162f5441e8a57e8ca6ac4c6deb","d772e0e1a8d2436a832798be1c837365"],"text":"30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4)","text_display":"30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4)","cell_row":0,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":0.6769509315490723,"confidence_rate":0.9945958153199675},{"cnt":[[1702,633],[1817,633],[1817,666],[1702,666]],"region":{"top_left_x":1702,"top_left_y":633,"width":116,"height":33},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"260928d0a59e45a6ac60e685731ab706","type":"text","conversion_output":false,"parent_id":"95682b2510d04b7abb01e938f76b1e09","text":"30 Days","text_display":"30 Days","confidence":1,"confidence_rate":1},{"cnt":[[1689,668],[1830,668],[1830,700],[1689,700]],"region":{"top_left_x":1689,"top_left_y":667,"width":142,"height":34},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0244b9d13d0461aa0ca75044f002b5e","type":"text","conversion_output":false,"parent_id":"95682b2510d04b7abb01e938f76b1e09","text":"( \\(\\pm 7\\) Days)","text_display":" ( \\(\\pm 7\\) Days)","confidence":0.6769509315490723,"confidence_rate":0.9785578620837116},{"cnt":[[1683,703],[1839,703],[1839,731],[1683,731]],"region":{"top_left_x":1682,"top_left_y":702,"width":157,"height":29},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e8824162f5441e8a57e8ca6ac4c6deb","type":"text","conversion_output":false,"parent_id":"95682b2510d04b7abb01e938f76b1e09","text":"Phone Call","text_display":" Phone Call","confidence":1,"confidence_rate":1},{"cnt":[[1707,737],[1813,737],[1813,770],[1707,770]],"region":{"top_left_x":1706,"top_left_y":737,"width":107,"height":33},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d772e0e1a8d2436a832798be1c837365","type":"text","conversion_output":false,"parent_id":"95682b2510d04b7abb01e938f76b1e09","text":"(Visit 4)","text_display":" (Visit 4)","confidence":1,"confidence_rate":1},{"cnt":[[1893,596],[2064,596],[2064,809],[1893,809]],"region":{"top_left_x":1892,"top_left_y":596,"width":172,"height":213},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f578625829046aa88672cf1655173fa","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["89b0a7d9e523481e9c8fa8461e604101","f8d40cad1fd44e54a769cf14003d9df8","926c6fafe8034a40b4b976b603b5488b","e147b0d821474939b81ed7963d71600c","6de5232a4d4e46a1a2adfa3a82c2ca0e","ad6743bdd49c43358c6d11c71c158bd5"],"text":"90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5)","text_display":"90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5)","cell_row":0,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":0.600173065206036,"confidence_rate":0.9952839590957852},{"cnt":[[1919,599],[2034,599],[2034,631],[1919,631]],"region":{"top_left_x":1918,"top_left_y":598,"width":116,"height":34},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89b0a7d9e523481e9c8fa8461e604101","type":"text","conversion_output":false,"parent_id":"3f578625829046aa88672cf1655173fa","text":"90 Days","text_display":"90 Days","confidence":1,"confidence_rate":1},{"cnt":[[1895,633],[2060,633],[2060,666],[1895,666]],"region":{"top_left_x":1895,"top_left_y":633,"width":165,"height":33},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8d40cad1fd44e54a769cf14003d9df8","type":"text","conversion_output":false,"parent_id":"3f578625829046aa88672cf1655173fa","text":"( ± 14 Days)/","text_display":" ( ± 14 Days)/","confidence":0.600173065206036,"confidence_rate":0.972035279814579},{"cnt":[[1936,668],[2021,668],[2021,703],[1936,703]],"region":{"top_left_x":1936,"top_left_y":667,"width":85,"height":36},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"926c6fafe8034a40b4b976b603b5488b","type":"text","conversion_output":false,"parent_id":"3f578625829046aa88672cf1655173fa","text":"Study","text_display":" Study","confidence":1,"confidence_rate":1},{"cnt":[[1897,703],[2055,703],[2055,735],[1897,735]],"region":{"top_left_x":1897,"top_left_y":702,"width":159,"height":34},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e147b0d821474939b81ed7963d71600c","type":"text","conversion_output":false,"parent_id":"3f578625829046aa88672cf1655173fa","text":"Completion","text_display":" Completion","confidence":1,"confidence_rate":1},{"cnt":[[1945,737],[2014,737],[2014,768],[1945,768]],"region":{"top_left_x":1944,"top_left_y":737,"width":71,"height":31},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6de5232a4d4e46a1a2adfa3a82c2ca0e","type":"text","conversion_output":false,"parent_id":"3f578625829046aa88672cf1655173fa","text":"Visit","text_display":" Visit","confidence":1,"confidence_rate":1},{"cnt":[[1923,772],[2029,772],[2029,804],[1923,804]],"region":{"top_left_x":1923,"top_left_y":771,"width":107,"height":34},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad6743bdd49c43358c6d11c71c158bd5","type":"text","conversion_output":false,"parent_id":"3f578625829046aa88672cf1655173fa","text":"(Visit 5)","text_display":" (Visit 5)","confidence":1,"confidence_rate":1},{"cnt":[[2101,631],[2315,631],[2315,774],[2101,774]],"region":{"top_left_x":2100,"top_left_y":631,"width":216,"height":144},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ceb179720f954cdc9dbb82ffb3350671","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["de9654a6523e4992a166e5032551f4e9","75bdab6f2e344b0592b4e45dda71b833","d7d563ad913e4abebb3a589ecf8f7e34","c49966626f6f4033b9b5e01b6c62ebdb"],"text":"Early Discontinuation (Phone call if possible)","text_display":"Early Discontinuation (Phone call if possible)","cell_row":0,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2174,633],[2248,633],[2248,668],[2174,668]],"region":{"top_left_x":2174,"top_left_y":633,"width":75,"height":35},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de9654a6523e4992a166e5032551f4e9","type":"text","conversion_output":false,"parent_id":"ceb179720f954cdc9dbb82ffb3350671","text":"Early","text_display":"Early","confidence":1,"confidence_rate":1},{"cnt":[[2105,668],[2311,668],[2311,696],[2105,696]],"region":{"top_left_x":2105,"top_left_y":667,"width":206,"height":30},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75bdab6f2e344b0592b4e45dda71b833","type":"text","conversion_output":false,"parent_id":"ceb179720f954cdc9dbb82ffb3350671","text":"Discontinuation","text_display":" Discontinuation","confidence":1,"confidence_rate":1},{"cnt":[[2122,703],[2300,703],[2300,735],[2122,735]],"region":{"top_left_x":2122,"top_left_y":702,"width":178,"height":34},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7d563ad913e4abebb3a589ecf8f7e34","type":"text","conversion_output":false,"parent_id":"ceb179720f954cdc9dbb82ffb3350671","text":"(Phone call if","text_display":" (Phone call if","confidence":1,"confidence_rate":1},{"cnt":[[2148,737],[2272,737],[2272,770],[2148,770]],"region":{"top_left_x":2148,"top_left_y":737,"width":124,"height":33},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c49966626f6f4033b9b5e01b6c62ebdb","type":"text","conversion_output":false,"parent_id":"ceb179720f954cdc9dbb82ffb3350671","text":"possible)","text_display":" possible)","confidence":1,"confidence_rate":1},{"cnt":[[433,828],[669,828],[669,856],[433,856]],"region":{"top_left_x":433,"top_left_y":828,"width":237,"height":29},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d45e8d69d78f4e28b13aaccf8bd59b7f","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Informed consent","text_display":"Informed consent","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[923,822],[957,822],[957,859],[923,859]],"region":{"top_left_x":922,"top_left_y":821,"width":36,"height":38},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af8a8cadf54f4a1491e47d930f84dbd8","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,880],[682,880],[682,913],[433,913]],"region":{"top_left_x":433,"top_left_y":880,"width":250,"height":33},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9a8e33448104a0891597749584e67b0","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Review of elig bility","text_display":"Review of elig bility","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[923,876],[957,876],[957,910],[923,910]],"region":{"top_left_x":922,"top_left_y":875,"width":36,"height":36},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1a73fee2fc145138b2533985b8fb467","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[429,928],[804,928],[804,995],[429,995]],"region":{"top_left_x":428,"top_left_y":927,"width":376,"height":68},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"42ca79207508495cb2d46d74520312ea","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["7091a56b051a45eb974fe69d7a8a74a9","051a506209684cc08eb5885846c04902"],"text":"Medical history and baseline conditions \\({ }^{\\text {a }}\\)","text_display":"Medical history and baseline conditions \\({ }^{\\text {a }}\\)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.98388671875,"confidence_rate":0.9997099615018246},{"cnt":[[433,928],[799,928],[799,960],[433,960]],"region":{"top_left_x":433,"top_left_y":927,"width":367,"height":34},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7091a56b051a45eb974fe69d7a8a74a9","type":"text","conversion_output":false,"parent_id":"42ca79207508495cb2d46d74520312ea","text":"Medical history and baseline","text_display":"Medical history and baseline","confidence":1,"confidence_rate":1},{"cnt":[[433,958],[583,958],[583,991],[433,991]],"region":{"top_left_x":433,"top_left_y":958,"width":150,"height":33},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"051a506209684cc08eb5885846c04902","type":"text","conversion_output":false,"parent_id":"42ca79207508495cb2d46d74520312ea","text":"conditions \\({ }^{\\text {a }}\\)","text_display":" conditions \\({ }^{\\text {a }}\\)","confidence":0.98388671875,"confidence_rate":0.9994200071259797},{"cnt":[[923,928],[957,928],[957,958],[923,958]],"region":{"top_left_x":922,"top_left_y":927,"width":36,"height":32},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b15ca1495256409d987bff433e5cf759","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1014],[622,1014],[622,1047],[433,1047]],"region":{"top_left_x":433,"top_left_y":1014,"width":189,"height":33},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97473000cf2e4bf3a61b311194d2e2f7","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Demographics","text_display":"Demographics","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[923,1014],[957,1014],[957,1045],[923,1045]],"region":{"top_left_x":922,"top_left_y":1014,"width":36,"height":31},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3615f92344444e7c86181e22d0bcd9c9","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1058],[734,1058],[734,1099],[433,1099]],"region":{"top_left_x":433,"top_left_y":1057,"width":302,"height":42},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8198f3039f824826876ba2a016a37a94","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Physical examination \\({ }^{\\text {b }}\\)","text_display":"Physical examination \\({ }^{\\text {b }}\\)","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[923,1064],[957,1064],[957,1092],[923,1092]],"region":{"top_left_x":922,"top_left_y":1064,"width":36,"height":29},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"789b2926157a40cb85fd301642c6ecc7","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1110],[585,1110],[585,1151],[433,1151]],"region":{"top_left_x":433,"top_left_y":1109,"width":152,"height":42},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6998bac330904f9299dce1493c741ee4","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Vital signs \\({ }^{\\text {c }}\\)","text_display":"Vital signs \\({ }^{\\text {c }}\\)","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.5278043746948242,"confidence_rate":0.9782055058994918},{"cnt":[[923,1114],[957,1114],[957,1144],[923,1144]],"region":{"top_left_x":922,"top_left_y":1114,"width":36,"height":31},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"301d70260cb24435aff647e0f6ea2bb8","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1160],[743,1160],[743,1198],[433,1198]],"region":{"top_left_x":433,"top_left_y":1159,"width":310,"height":40},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba8a5d4ed90c4811b4283e62b34a2538","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Complete blood count \\({ }^{\\text {d }}\\)","text_display":"Complete blood count \\({ }^{\\text {d }}\\)","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.96142578125,"confidence_rate":0.9989653275504088},{"cnt":[[923,1166],[957,1166],[957,1196],[923,1196]],"region":{"top_left_x":922,"top_left_y":1166,"width":36,"height":31},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"059e82aa2b754d8a9d6438c6399c90d0","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1214],[700,1214],[700,1250],[433,1250]],"region":{"top_left_x":433,"top_left_y":1213,"width":267,"height":38},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fbe1dddf1e5b472fbf1fab4b1baf986c","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Coagulation status \\({ }^{\\text {e }}\\)","text_display":"Coagulation status \\({ }^{\\text {e }}\\)","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.98681640625,"confidence_rate":0.999631421587391},{"cnt":[[923,1211],[957,1211],[957,1246],[923,1246]],"region":{"top_left_x":922,"top_left_y":1211,"width":36,"height":36},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70041c555fc5442492231b72ee2df2fb","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[433,1261],[643,1261],[643,1302],[433,1302]],"region":{"top_left_x":433,"top_left_y":1261,"width":211,"height":42},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d93ac425dccd4b9b9305ef4296a4e6ec","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Pregnancy test \\({ }^{ f }\\)","text_display":"Pregnancy test \\({ }^{ f }\\)","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.94189453125,"confidence_rate":0.9980065903768529},{"cnt":[[923,1261],[957,1261],[957,1296],[923,1296]],"region":{"top_left_x":922,"top_left_y":1261,"width":36,"height":35},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bdf87d8d222e44e5bc6497a7e9e618ef","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":9,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1313],[726,1313],[726,1350],[433,1350]],"region":{"top_left_x":433,"top_left_y":1313,"width":293,"height":38},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6b073a9f78734403a94896464984c2d6","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Serum blood glucose \\({ }^{\\text {g }}\\)","text_display":"Serum blood glucose \\({ }^{\\text {g }}\\)","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.84375,"confidence_rate":0.9954186606384479},{"cnt":[[923,1313],[957,1313],[957,1348],[923,1348]],"region":{"top_left_x":922,"top_left_y":1313,"width":36,"height":35},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6083142558904896a07336b82c0e290a","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":10,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[429,1365],[838,1365],[838,1612],[429,1612]],"region":{"top_left_x":428,"top_left_y":1365,"width":411,"height":248},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d2fbcdf3618b47fdaa16097f353a5355","type":"complex_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","children_ids":["7545cc8e011148dfa6d461ff183252e0","84c9fba8a14c485d878ca4034fc83f85","493f5e7e9e2345aa8122d41b7160d744","0c4f5d066e6d4a2bb1d06620eb89374b","3e2c0ea7ce0b422b98fb430a4f750a9d","dd5843d8278242559f631ca2c616b067","3fecd70b1c4944eea8d1748c0c58a586"],"text":"Imaging modality sensitive to presence of intracranial hemorrhage (either CT or MRI with DW MRI, either SW or GRE, and FLAIR images). Visit 2 MRIs should also include T1 and T2 sequences","text_display":"Imaging modality sensitive to presence of intracranial hemorrhage (either CT or MRI with DW MRI, either SW or GRE, and FLAIR images). Visit 2 MRIs should also include T1 and T2 sequences","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1365],[808,1365],[808,1400],[433,1400]],"region":{"top_left_x":433,"top_left_y":1365,"width":375,"height":35},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7545cc8e011148dfa6d461ff183252e0","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"Imaging modality sensitive to","text_display":"Imaging modality sensitive to","confidence":1,"confidence_rate":1},{"cnt":[[433,1400],[734,1400],[734,1432],[433,1432]],"region":{"top_left_x":433,"top_left_y":1399,"width":302,"height":34},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84c9fba8a14c485d878ca4034fc83f85","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"presence of intracranial","text_display":" presence of intracranial","confidence":1,"confidence_rate":1},{"cnt":[[433,1430],[821,1430],[821,1463],[433,1463]],"region":{"top_left_x":433,"top_left_y":1430,"width":388,"height":33},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"493f5e7e9e2345aa8122d41b7160d744","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"hemorrhage (either CT or MRI","text_display":" hemorrhage (either CT or MRI","confidence":1,"confidence_rate":1},{"cnt":[[433,1465],[782,1465],[782,1497],[433,1497]],"region":{"top_left_x":433,"top_left_y":1464,"width":349,"height":34},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c4f5d066e6d4a2bb1d06620eb89374b","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"with DW MRI, either SW or","text_display":" with DW MRI, either SW or","confidence":1,"confidence_rate":1},{"cnt":[[433,1499],[834,1499],[834,1532],[433,1532]],"region":{"top_left_x":433,"top_left_y":1499,"width":401,"height":33},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e2c0ea7ce0b422b98fb430a4f750a9d","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"GRE, and FLAIR images). Visit","text_display":" GRE, and FLAIR images). Visit","confidence":1,"confidence_rate":1},{"cnt":[[429,1532],[821,1532],[821,1562],[429,1562]],"region":{"top_left_x":428,"top_left_y":1531,"width":393,"height":32},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd5843d8278242559f631ca2c616b067","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"2 MRIs should also include T1","text_display":" 2 MRIs should also include T1","confidence":1,"confidence_rate":1},{"cnt":[[433,1573],[678,1573],[678,1610],[433,1610]],"region":{"top_left_x":433,"top_left_y":1573,"width":246,"height":37},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fecd70b1c4944eea8d1748c0c58a586","type":"text","conversion_output":false,"parent_id":"d2fbcdf3618b47fdaa16097f353a5355","text":"and T2 sequences","text_display":" and T2 sequences","confidence":1,"confidence_rate":1},{"cnt":[[923,1367],[957,1367],[957,1402],[923,1402]],"region":{"top_left_x":922,"top_left_y":1367,"width":36,"height":36},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d1c5e0611434929a6afd9e1f8c278ee","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[1338,1367],[1364,1367],[1364,1402],[1338,1402]],"region":{"top_left_x":1338,"top_left_y":1367,"width":27,"height":36},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac74e58f47eb4a1d83f2fe07e0c4bf22","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":11,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1612],[617,1612],[617,1649],[433,1649]],"region":{"top_left_x":433,"top_left_y":1612,"width":185,"height":37},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7858b14729844c979a6932ef6321b32e","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"NIHSS score \\({ }^{i}\\)","text_display":"NIHSS score \\({ }^{i}\\)","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.5087890625,"confidence_rate":0.9722375868313742},{"cnt":[[923,1621],[957,1621],[957,1651],[923,1651]],"region":{"top_left_x":922,"top_left_y":1620,"width":36,"height":32},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b208505e0dc475cae3dfe6d638db9ab","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":12,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1338,1621],[1364,1621],[1364,1651],[1338,1651]],"region":{"top_left_x":1338,"top_left_y":1620,"width":27,"height":32},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bb250680e4a644398ad0a665e680639f","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":12,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1544,1621],[1568,1621],[1568,1651],[1544,1651]],"region":{"top_left_x":1544,"top_left_y":1620,"width":25,"height":32},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbccbedde5ce4d00983ea224581464ad","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":12,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1966,1621],[1992,1621],[1992,1651],[1966,1651]],"region":{"top_left_x":1966,"top_left_y":1620,"width":27,"height":32},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b3f9211e688346bcaea84fccbccd62e6","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":12,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[433,1671],[773,1671],[773,1705],[433,1705]],"region":{"top_left_x":433,"top_left_y":1670,"width":341,"height":36},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"befaf439753947efbdc69e967f067b1e","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"Study drug administration","text_display":"Study drug administration","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1133,1673],[1161,1673],[1161,1699],[1133,1699]],"region":{"top_left_x":1132,"top_left_y":1672,"width":29,"height":27},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9ea7304222b47099e456c6abff26a73","type":"simple_cell","conversion_output":false,"parent_id":"14e87a5f2e67440cb8eeb14e8d671713","text":"X","text_display":"X","cell_row":13,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[434,1792],[1205,1792],[1205,1833],[434,1833]],"region":{"top_left_x":433,"top_left_y":1791,"width":773,"height":42},"line":103,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f9aa345b39f045ae980b7291f7c0075a","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":0.9990234375,"confidence_rate":0.9999825530156321},{"cnt":[[434,1830],[604,1830],[604,1863],[434,1863]],"region":{"top_left_x":433,"top_left_y":1830,"width":171,"height":33},"line":104,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0b4630d1ab4443c4bd52ae1d25fde7a4","type":"text","conversion_output":true,"text":"39/ML29093","text_display":"\n39/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,1830],[1184,1830],[1184,1863],[1044,1863]],"region":{"top_left_x":1044,"top_left_y":1830,"width":140,"height":33},"line":105,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f68b33db071f4288aef745988b85e7a0","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,1946],[1420,1946],[1420,1992],[370,1992]],"region":{"top_left_x":369,"top_left_y":1946,"width":1052,"height":46},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d65143e6d494eda9c006277e316678d","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9980480668600649,"confidence_rate":0.9999699413649383},{"cnt":[[370,1985],[694,1985],[694,2022],[370,2022]],"region":{"top_left_x":369,"top_left_y":1985,"width":325,"height":37},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5ec819543214f24b715c3b871d9b247","type":"page_info","conversion_output":false,"text":"800/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-41","page":41,"lines":[{"cnt":[[419,434],[2331,434],[2331,1366],[419,1366]],"region":{"top_left_x":418,"top_left_y":433,"width":1914,"height":934},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"107a27022801431c9187297b4950614d","type":"table","conversion_output":true,"children_ids":["acd5aa998370446e838c7fa515816554","146a82f3742a42bdb455ed3a3c342d9d","a9a88d89fcfd4e10b9faa27eceadf051","717c4e202da34cd6ac8904cf83cd2092","737b829a26be4c018a4aaf14b87c48de","8e87f3ce580d4fb781134a86e3529a9f","8c33d2778f3c478caef75cec3e828116","8f47630a550d48faa06d6afc107bc449","19681236e3d449648549cf39870f2f89","985fc065dbfe4e27957b3a7b8ca98dc2","de6d0d57bd124a13b0a0ddef065d05ea","50544b2b90ed4a129ee9feef176d2b4a","abc867331f0f4142a13007c8df8e2036","7ba6ead0809445258715756c872ea48b","07f6c2aa7f93492ca5c110be25aa4f3d","789e4e1ed6d3483eaa71c7c3f538ee55","d1985a2611024a029fad3ffbaba59995","4ac6c0e6340b4cd7b335065ecdb408e0","8ee99da751454a31a45f152320a28e59","35418db5897349d3abcab4e8d11c482a","e0578be23c9449a58b829b3f612aa600","48db1041f50d4ac69de0bc9582d05938","2e74e791555d447b92a8a1cc40a7abb3","4f2fe8df125345b9a8226fb9636e5089","7884818b93b24630a0b03a09c54ad4cd","34d651857d2d41359a1cecedc4b3ec35","db35946069f74217bef7984d2e338133","9d9eef712e9b4e62bb679ac30bda08ab","584cd2491a044eca8fa2fa5a01b25868","7a1a1095df38453b88a4ed677b86250a","fda18f18603a4caa9170a98f73eb3168","46275ae2f878481f9eff7223ac5e26d4","8c2a8f8eae9343d1a1352b75360ce5f8","8819353dfe29494c9b48be723b27073d","6d1c32673fb04a3e8bb8b27e2b8cbe7f","2f529ef468c14b4da8b018c145a9a605","9a4019da237b44c2a3215626a6235597","d67c894f2b014db9a93b4d7bf5905842","c6661a8b34c544b0aea40b49c6633cf2","ac0332dab5154433be5628cb80afd980","02c4b1c9438345deac4f37499a8fa6f8","440f00ae5b3e4dfdb1c323416e7361a6","f4b8109bca8246ccb258b977d0b84320","3a59fafc644349aca409cacd8af15310","c77267f283bb401899192b52903cc41f","4e86d4841ef248c69805f4c56ba7a063","d0c0a96588f149eaa5cb8e7ad3eecda8","3fea3b39ab0a40fb8621993bd395195e","cf3ffe4a845c45c3aae6daf87e147bec","e2a0a0c71d7d487385c697791ff7c0b6","e0e6b68ba9594214a426db6c79c99ca7","41db54148cae410f93acb078ca1ebd69","02db14a7b17343308bdaf0f24c4b5062","4a37a444221d4876a9ad1be553d980aa","293a01f06ebe47f9994231befb99231a","c0fda3d47f1643cf816620cf658f9370","9c004f74e2274b9b803d91a6844f69d6","0c76ba8d37e34308843ee959bf50586d","40abdeb62c064b2cabd90befcab5a896","4611eadf3aa743659a480dbe982032d1","7f8a4cbe44a741bd9f7950c08a6f8881","7d6168fe7d6e42238087df7023cebb2e","54e66c869d4f4b4ca068f5a9ac7a461f","7bec3ff15e224847afdbc0d378bb7bd9","10c84fc869694fe2832438b626bf78e4","e824590d24024d00a014bb8ecc05144a","868e8dfc77d747c98f8816084d26016a","7ad60fb99a394b0ca1a9255d78667c8e","a89f0bd4127b47c7b0b01ac647d57904","b1646740bb6d44c6bf832e8a3c70b49c","5bd5873004f240cabdfa93961c0128c6"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4) & 90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5) & Early Discontinuation (Phone call if possible) \\\\\n\\hline Discharge location & & & & X & & & \\\\\n\\hline Patient survival & & & X & X & X & X & x \\\\\n\\hline mRS \\({ }^{ j }\\) & & & & & X & X & \\\\\n\\hline GOS & & & & & & X & \\\\\n\\hline BI \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline EQ-5D \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline CES-D \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline SIS-16 \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline Cognitive assessment \\({ }^{1}\\) & & & & & & X & \\\\\n\\hline Waking speed \\({ }^{\\text {m }}\\) & & & & & & X & \\\\\n\\hline Concomitant medications \\({ }^{\\text {n }}\\) & X & & X & X & X & X & X \\\\\n\\hline Assessment of pregnancy & & & & & X & & \\\\\n\\hline Adverse event \\({ }^{\\circ}\\) & X & & X & X & X & X & X \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4) & 90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5) & Early Discontinuation (Phone call if possible) \\\\\n\\hline Discharge location & & & & X & & & \\\\\n\\hline Patient survival & & & X & X & X & X & x \\\\\n\\hline mRS \\({ }^{ j }\\) & & & & & X & X & \\\\\n\\hline GOS & & & & & & X & \\\\\n\\hline BI \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline EQ-5D \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline CES-D \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline SIS-16 \\({ }^{ k }\\) & & & & & & X & \\\\\n\\hline Cognitive assessment \\({ }^{1}\\) & & & & & & X & \\\\\n\\hline Waking speed \\({ }^{\\text {m }}\\) & & & & & & X & \\\\\n\\hline Concomitant medications \\({ }^{\\text {n }}\\) & X & & X & X & X & X & X \\\\\n\\hline Assessment of pregnancy & & & & & X & & \\\\\n\\hline Adverse event \\({ }^{\\circ}\\) & X & & X & X & X & X & X \\\\\n\\hline\n\\end{tabular}","confidence":0.49560546875,"confidence_rate":0.9951407134743561},{"cnt":[[424,433],[790,433],[790,1366],[424,1366]],"region":{"top_left_x":424,"top_left_y":433,"width":367,"height":934},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"acd5aa998370446e838c7fa515816554","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[842,433],[1046,433],[1046,1366],[842,1366]],"region":{"top_left_x":842,"top_left_y":433,"width":204,"height":934},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"146a82f3742a42bdb455ed3a3c342d9d","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[1048,433],[1245,433],[1245,1366],[1048,1366]],"region":{"top_left_x":1048,"top_left_y":433,"width":198,"height":934},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9a88d89fcfd4e10b9faa27eceadf051","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[1252,433],[1447,433],[1447,1366],[1252,1366]],"region":{"top_left_x":1251,"top_left_y":433,"width":196,"height":934},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"717c4e202da34cd6ac8904cf83cd2092","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[1460,433],[1652,433],[1652,1366],[1460,1366]],"region":{"top_left_x":1459,"top_left_y":433,"width":194,"height":934},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"737b829a26be4c018a4aaf14b87c48de","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[1674,433],[1845,433],[1845,1366],[1674,1366]],"region":{"top_left_x":1673,"top_left_y":433,"width":173,"height":934},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e87f3ce580d4fb781134a86e3529a9f","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[1882,433],[2070,433],[2070,1366],[1882,1366]],"region":{"top_left_x":1881,"top_left_y":433,"width":190,"height":934},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c33d2778f3c478caef75cec3e828116","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[2098,433],[2317,433],[2317,1366],[2098,1366]],"region":{"top_left_x":2098,"top_left_y":433,"width":220,"height":934},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f47630a550d48faa06d6afc107bc449","type":"table_column","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,444],[2334,441],[2335,666],[418,669]],"region":{"top_left_x":417,"top_left_y":441,"width":1918,"height":228},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19681236e3d449648549cf39870f2f89","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,678],[2332,678],[2332,719],[418,719]],"region":{"top_left_x":418,"top_left_y":677,"width":1915,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"985fc065dbfe4e27957b3a7b8ca98dc2","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,728],[2334,728],[2334,766],[418,766]],"region":{"top_left_x":418,"top_left_y":727,"width":1917,"height":40},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"de6d0d57bd124a13b0a0ddef065d05ea","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,771],[2334,771],[2334,816],[418,816]],"region":{"top_left_x":418,"top_left_y":770,"width":1917,"height":47},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50544b2b90ed4a129ee9feef176d2b4a","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,827],[2332,827],[2332,864],[418,864]],"region":{"top_left_x":418,"top_left_y":827,"width":1915,"height":37},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abc867331f0f4142a13007c8df8e2036","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,875],[2334,875],[2334,916],[418,916]],"region":{"top_left_x":418,"top_left_y":874,"width":1917,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ba6ead0809445258715756c872ea48b","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,942],[2334,942],[2334,985],[418,985]],"region":{"top_left_x":418,"top_left_y":941,"width":1917,"height":45},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07f6c2aa7f93492ca5c110be25aa4f3d","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1007],[2334,1007],[2334,1048],[418,1048]],"region":{"top_left_x":418,"top_left_y":1006,"width":1917,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"789e4e1ed6d3483eaa71c7c3f538ee55","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1057],[2334,1057],[2334,1098],[418,1098]],"region":{"top_left_x":418,"top_left_y":1056,"width":1917,"height":42},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d1985a2611024a029fad3ffbaba59995","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1109],[2334,1109],[2334,1152],[418,1152]],"region":{"top_left_x":418,"top_left_y":1108,"width":1917,"height":44},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4ac6c0e6340b4cd7b335065ecdb408e0","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1161],[2334,1161],[2334,1202],[418,1202]],"region":{"top_left_x":418,"top_left_y":1160,"width":1917,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8ee99da751454a31a45f152320a28e59","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1213],[2334,1213],[2334,1249],[418,1249]],"region":{"top_left_x":418,"top_left_y":1212,"width":1917,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"35418db5897349d3abcab4e8d11c482a","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1267],[2334,1267],[2334,1304],[418,1304]],"region":{"top_left_x":418,"top_left_y":1266,"width":1917,"height":38},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0578be23c9449a58b829b3f612aa600","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[418,1312],[2332,1312],[2332,1349],[418,1349]],"region":{"top_left_x":418,"top_left_y":1312,"width":1915,"height":38},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48db1041f50d4ac69de0bc9582d05938","type":"table_row","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"","text_display":""},{"cnt":[[513,539],[751,539],[751,569],[513,569]],"region":{"top_left_x":513,"top_left_y":539,"width":239,"height":31},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e74e791555d447b92a8a1cc40a7abb3","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"ASSESSMENTS","text_display":"ASSESSMENTS","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[847,502],[1039,502],[1039,608],[847,608]],"region":{"top_left_x":846,"top_left_y":502,"width":194,"height":107},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f2fe8df125345b9a8226fb9636e5089","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["b1fb5b19e1e54606addc0fab49253c02","eec66481eec141a1a111e13559775314","c45144fe398a429a9191de031e98f461"],"text":"Screening and Baseline (Visit 1)","text_display":"Screening and Baseline (Visit 1)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[847,507],[1037,507],[1037,539],[847,539]],"region":{"top_left_x":846,"top_left_y":506,"width":192,"height":34},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1fb5b19e1e54606addc0fab49253c02","type":"text","conversion_output":false,"parent_id":"4f2fe8df125345b9a8226fb9636e5089","text":"Screening and","text_display":"Screening and","confidence":1,"confidence_rate":1},{"cnt":[[886,541],[1001,541],[1001,569],[886,569]],"region":{"top_left_x":885,"top_left_y":541,"width":116,"height":29},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eec66481eec141a1a111e13559775314","type":"text","conversion_output":false,"parent_id":"4f2fe8df125345b9a8226fb9636e5089","text":"Baseline","text_display":" Baseline","confidence":1,"confidence_rate":1},{"cnt":[[892,574],[994,574],[994,608],[892,608]],"region":{"top_left_x":892,"top_left_y":573,"width":103,"height":36},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c45144fe398a429a9191de031e98f461","type":"text","conversion_output":false,"parent_id":"4f2fe8df125345b9a8226fb9636e5089","text":"(Visit 1)","text_display":" (Visit 1)","confidence":1,"confidence_rate":1},{"cnt":[[1052,520],[1243,520],[1243,587],[1052,587]],"region":{"top_left_x":1052,"top_left_y":519,"width":192,"height":68},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7884818b93b24630a0b03a09c54ad4cd","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["16e6ba34348d4cc99e85f95d174f1944","38b3dc6377374ecf8f2ba1f82796583c"],"text":"Study Drug Administration","text_display":"Study Drug Administration","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1072,524],[1221,524],[1221,556],[1072,556]],"region":{"top_left_x":1071,"top_left_y":523,"width":151,"height":34},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16e6ba34348d4cc99e85f95d174f1944","type":"text","conversion_output":false,"parent_id":"7884818b93b24630a0b03a09c54ad4cd","text":"Study Drug","text_display":"Study Drug","confidence":1,"confidence_rate":1},{"cnt":[[1055,559],[1239,559],[1239,587],[1055,587]],"region":{"top_left_x":1054,"top_left_y":558,"width":185,"height":29},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38b3dc6377374ecf8f2ba1f82796583c","type":"text","conversion_output":false,"parent_id":"7884818b93b24630a0b03a09c54ad4cd","text":"Administration","text_display":" Administration","confidence":1,"confidence_rate":1},{"cnt":[[1254,452],[1447,452],[1447,660],[1254,660]],"region":{"top_left_x":1253,"top_left_y":452,"width":194,"height":209},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34d651857d2d41359a1cecedc4b3ec35","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["49ca95f9288f4571add1b41a025be5f4","44e631d53f4642419c1c6d226d70790b","2b87069a4d0b4e48aeca4a7d22f39d04","483a45640e5643239ee0aa76b03a45a7","b68921cfcef848388c35089e7e3760f1","cc8ab61ba7c9430c8330cf8804fe2413"],"text":"22-36 Hours from Start of Study Drug Administration (Visit 2)","text_display":"22-36 Hours from Start of Study Drug Administration (Visit 2)","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1308,455],[1397,455],[1397,485],[1308,485]],"region":{"top_left_x":1308,"top_left_y":454,"width":89,"height":31},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"49ca95f9288f4571add1b41a025be5f4","type":"text","conversion_output":false,"parent_id":"34d651857d2d41359a1cecedc4b3ec35","text":"22-36","text_display":"22-36","confidence":1,"confidence_rate":1},{"cnt":[[1276,489],[1425,489],[1425,517],[1276,517]],"region":{"top_left_x":1275,"top_left_y":489,"width":150,"height":29},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"44e631d53f4642419c1c6d226d70790b","type":"text","conversion_output":false,"parent_id":"34d651857d2d41359a1cecedc4b3ec35","text":"Hours from","text_display":" Hours from","confidence":1,"confidence_rate":1},{"cnt":[[1297,524],[1408,524],[1408,552],[1297,552]],"region":{"top_left_x":1297,"top_left_y":523,"width":111,"height":30},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b87069a4d0b4e48aeca4a7d22f39d04","type":"text","conversion_output":false,"parent_id":"34d651857d2d41359a1cecedc4b3ec35","text":"Start of","text_display":" Start of","confidence":1,"confidence_rate":1},{"cnt":[[1278,559],[1425,559],[1425,591],[1278,591]],"region":{"top_left_x":1277,"top_left_y":558,"width":148,"height":34},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"483a45640e5643239ee0aa76b03a45a7","type":"text","conversion_output":false,"parent_id":"34d651857d2d41359a1cecedc4b3ec35","text":"Study Drug","text_display":" Study Drug","confidence":1,"confidence_rate":1},{"cnt":[[1258,593],[1442,593],[1442,621],[1258,621]],"region":{"top_left_x":1258,"top_left_y":593,"width":185,"height":29},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b68921cfcef848388c35089e7e3760f1","type":"text","conversion_output":false,"parent_id":"34d651857d2d41359a1cecedc4b3ec35","text":"Administration","text_display":" Administration","confidence":1,"confidence_rate":1},{"cnt":[[1302,628],[1403,628],[1403,660],[1302,660]],"region":{"top_left_x":1301,"top_left_y":627,"width":103,"height":34},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc8ab61ba7c9430c8330cf8804fe2413","type":"text","conversion_output":false,"parent_id":"34d651857d2d41359a1cecedc4b3ec35","text":"(Visit 2)","text_display":" (Visit 2)","confidence":1,"confidence_rate":1},{"cnt":[[1462,485],[1646,485],[1646,626],[1462,626]],"region":{"top_left_x":1461,"top_left_y":484,"width":185,"height":142},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db35946069f74217bef7984d2e338133","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["3793ba31e5a44ded8268a65250d380f3","8773de1c22c6404e94aecc6c4d15e59d","88466d7f916f4f4b8ce3f9a34e8ee5b3","82cedfad046844c48b06e06063f51d22"],"text":"Day 5 (or Discharge if Sooner) (Visit 3)","text_display":"Day 5 (or Discharge if Sooner) (Visit 3)","cell_row":0,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999932166827553},{"cnt":[[1514,489],[1600,489],[1600,524],[1514,524]],"region":{"top_left_x":1513,"top_left_y":489,"width":88,"height":35},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3793ba31e5a44ded8268a65250d380f3","type":"text","conversion_output":false,"parent_id":"db35946069f74217bef7984d2e338133","text":"Day 5","text_display":"Day 5","confidence":1,"confidence_rate":1},{"cnt":[[1464,524],[1646,524],[1646,556],[1464,556]],"region":{"top_left_x":1463,"top_left_y":523,"width":183,"height":34},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8773de1c22c6404e94aecc6c4d15e59d","type":"text","conversion_output":false,"parent_id":"db35946069f74217bef7984d2e338133","text":"(or Discharge","text_display":" (or Discharge","confidence":0.99951171875,"confidence_rate":0.9999728670071003},{"cnt":[[1488,559],[1620,559],[1620,591],[1488,591]],"region":{"top_left_x":1487,"top_left_y":558,"width":133,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88466d7f916f4f4b8ce3f9a34e8ee5b3","type":"text","conversion_output":false,"parent_id":"db35946069f74217bef7984d2e338133","text":"if Sooner)","text_display":" if Sooner)","confidence":1,"confidence_rate":1},{"cnt":[[1503,593],[1607,593],[1607,626],[1503,626]],"region":{"top_left_x":1502,"top_left_y":593,"width":105,"height":33},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"82cedfad046844c48b06e06063f51d22","type":"text","conversion_output":false,"parent_id":"db35946069f74217bef7984d2e338133","text":"(Visit 3)","text_display":" (Visit 3)","confidence":1,"confidence_rate":1},{"cnt":[[1678,487],[1836,487],[1836,628],[1678,628]],"region":{"top_left_x":1678,"top_left_y":487,"width":159,"height":141},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d9eef712e9b4e62bb679ac30bda08ab","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["647bec59b7bc477b87fd84f6a10b86ab","f3e672c6c0ae444d89c02147ef1839b0","5aaf2366e2194fa18d606beb0dc06619","7dad2ad1eb2e4f4eae6c6831cb2b7c79"],"text":"30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4)","text_display":"30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4)","cell_row":0,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":0.7951245307922363,"confidence_rate":0.9968209454002466},{"cnt":[[1702,489],[1815,489],[1815,522],[1702,522]],"region":{"top_left_x":1702,"top_left_y":489,"width":113,"height":33},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"647bec59b7bc477b87fd84f6a10b86ab","type":"text","conversion_output":false,"parent_id":"9d9eef712e9b4e62bb679ac30bda08ab","text":"30 Days","text_display":"30 Days","confidence":1,"confidence_rate":1},{"cnt":[[1691,524],[1830,524],[1830,556],[1691,556]],"region":{"top_left_x":1691,"top_left_y":523,"width":139,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3e672c6c0ae444d89c02147ef1839b0","type":"text","conversion_output":false,"parent_id":"9d9eef712e9b4e62bb679ac30bda08ab","text":"( \\(\\pm 7\\) Days)","text_display":" ( \\(\\pm 7\\) Days)","confidence":0.7951245307922363,"confidence_rate":0.9873442915169759},{"cnt":[[1683,559],[1834,559],[1834,587],[1683,587]],"region":{"top_left_x":1682,"top_left_y":558,"width":153,"height":29},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5aaf2366e2194fa18d606beb0dc06619","type":"text","conversion_output":false,"parent_id":"9d9eef712e9b4e62bb679ac30bda08ab","text":"Phone Call","text_display":" Phone Call","confidence":1,"confidence_rate":1},{"cnt":[[1704,593],[1815,593],[1815,626],[1704,626]],"region":{"top_left_x":1704,"top_left_y":593,"width":111,"height":33},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7dad2ad1eb2e4f4eae6c6831cb2b7c79","type":"text","conversion_output":false,"parent_id":"9d9eef712e9b4e62bb679ac30bda08ab","text":"(Visit 4)","text_display":" (Visit 4)","confidence":1,"confidence_rate":1},{"cnt":[[1893,452],[2062,452],[2062,660],[1893,660]],"region":{"top_left_x":1892,"top_left_y":452,"width":170,"height":209},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"584cd2491a044eca8fa2fa5a01b25868","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["abd297a9e1094dd287529420bb1af92e","b60b3dd9526748b78428a2b06e9859f7","08c5f7f92b314d349393e5b35c67ba3e","7e2b36610085435883009780230ae4f3","828f1ed1e2404675b46700b817d37377","f575349b92ca4e08bcd0811b25a168ba"],"text":"90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5)","text_display":"90 Days ( ± 14 Days)/ Study Completion Visit (Visit 5)","cell_row":0,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":0.5479737056884915,"confidence_rate":0.9944457785647104},{"cnt":[[1919,455],[2031,455],[2031,487],[1919,487]],"region":{"top_left_x":1918,"top_left_y":454,"width":114,"height":34},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"abd297a9e1094dd287529420bb1af92e","type":"text","conversion_output":false,"parent_id":"584cd2491a044eca8fa2fa5a01b25868","text":"90 Days","text_display":"90 Days","confidence":1,"confidence_rate":1},{"cnt":[[1895,489],[2057,489],[2057,522],[1895,522]],"region":{"top_left_x":1894,"top_left_y":489,"width":164,"height":33},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b60b3dd9526748b78428a2b06e9859f7","type":"text","conversion_output":false,"parent_id":"584cd2491a044eca8fa2fa5a01b25868","text":"( ± 14 Days)/","text_display":" ( ± 14 Days)/","confidence":0.5479737056884915,"confidence_rate":0.9671339993828382},{"cnt":[[1934,524],[2020,524],[2020,559],[1934,559]],"region":{"top_left_x":1933,"top_left_y":523,"width":88,"height":36},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08c5f7f92b314d349393e5b35c67ba3e","type":"text","conversion_output":false,"parent_id":"584cd2491a044eca8fa2fa5a01b25868","text":"Study","text_display":" Study","confidence":1,"confidence_rate":1},{"cnt":[[1895,559],[2057,559],[2057,591],[1895,591]],"region":{"top_left_x":1894,"top_left_y":558,"width":164,"height":34},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e2b36610085435883009780230ae4f3","type":"text","conversion_output":false,"parent_id":"584cd2491a044eca8fa2fa5a01b25868","text":"Completion","text_display":" Completion","confidence":1,"confidence_rate":1},{"cnt":[[1945,593],[2012,593],[2012,624],[1945,624]],"region":{"top_left_x":1944,"top_left_y":593,"width":68,"height":31},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"828f1ed1e2404675b46700b817d37377","type":"text","conversion_output":false,"parent_id":"584cd2491a044eca8fa2fa5a01b25868","text":"Visit","text_display":" Visit","confidence":1,"confidence_rate":1},{"cnt":[[1921,628],[2031,628],[2031,660],[1921,660]],"region":{"top_left_x":1920,"top_left_y":627,"width":112,"height":34},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f575349b92ca4e08bcd0811b25a168ba","type":"text","conversion_output":false,"parent_id":"584cd2491a044eca8fa2fa5a01b25868","text":"(Visit 5)","text_display":" (Visit 5)","confidence":1,"confidence_rate":1},{"cnt":[[2103,487],[2313,487],[2313,626],[2103,626]],"region":{"top_left_x":2102,"top_left_y":487,"width":211,"height":139},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a1a1095df38453b88a4ed677b86250a","type":"complex_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","children_ids":["704d2b53c25e497aa82e9a27a2a17f26","4c4ee1d8b12d41fcb4112ed263087619","b6b36c89d481465c877ee83d3e4eb19b","994e57206493498eae4f87ae189ab4bb"],"text":"Early Discontinuation (Phone call if possible)","text_display":"Early Discontinuation (Phone call if possible)","cell_row":0,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2172,489],[2246,489],[2246,524],[2172,524]],"region":{"top_left_x":2172,"top_left_y":489,"width":74,"height":35},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"704d2b53c25e497aa82e9a27a2a17f26","type":"text","conversion_output":false,"parent_id":"7a1a1095df38453b88a4ed677b86250a","text":"Early","text_display":"Early","confidence":1,"confidence_rate":1},{"cnt":[[2103,524],[2313,524],[2313,552],[2103,552]],"region":{"top_left_x":2102,"top_left_y":523,"width":211,"height":30},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c4ee1d8b12d41fcb4112ed263087619","type":"text","conversion_output":false,"parent_id":"7a1a1095df38453b88a4ed677b86250a","text":"Discontinuation","text_display":" Discontinuation","confidence":1,"confidence_rate":1},{"cnt":[[2120,559],[2300,559],[2300,591],[2120,591]],"region":{"top_left_x":2120,"top_left_y":558,"width":180,"height":34},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b6b36c89d481465c877ee83d3e4eb19b","type":"text","conversion_output":false,"parent_id":"7a1a1095df38453b88a4ed677b86250a","text":"(Phone call if","text_display":" (Phone call if","confidence":1,"confidence_rate":1},{"cnt":[[2146,593],[2269,593],[2269,626],[2146,626]],"region":{"top_left_x":2146,"top_left_y":593,"width":124,"height":33},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"994e57206493498eae4f87ae189ab4bb","type":"text","conversion_output":false,"parent_id":"7a1a1095df38453b88a4ed677b86250a","text":"possible)","text_display":" possible)","confidence":1,"confidence_rate":1},{"cnt":[[431,682],[680,682],[680,717],[431,717]],"region":{"top_left_x":430,"top_left_y":682,"width":251,"height":35},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fda18f18603a4caa9170a98f73eb3168","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Discharge location","text_display":"Discharge location","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1544,680],[1570,680],[1570,715],[1544,715]],"region":{"top_left_x":1544,"top_left_y":679,"width":27,"height":36},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46275ae2f878481f9eff7223ac5e26d4","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":1,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,732],[637,732],[637,760],[431,760]],"region":{"top_left_x":430,"top_left_y":731,"width":207,"height":29},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8c2a8f8eae9343d1a1352b75360ce5f8","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Patient survival","text_display":"Patient survival","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1340,732],[1366,732],[1366,762],[1340,762]],"region":{"top_left_x":1340,"top_left_y":731,"width":27,"height":32},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8819353dfe29494c9b48be723b27073d","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1544,732],[1570,732],[1570,762],[1544,762]],"region":{"top_left_x":1544,"top_left_y":731,"width":27,"height":32},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d1c32673fb04a3e8bb8b27e2b8cbe7f","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":2,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1745,732],[1780,732],[1780,762],[1745,762]],"region":{"top_left_x":1745,"top_left_y":731,"width":36,"height":32},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f529ef468c14b4da8b018c145a9a605","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":2,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1964,732],[1990,732],[1990,762],[1964,762]],"region":{"top_left_x":1964,"top_left_y":731,"width":27,"height":32},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a4019da237b44c2a3215626a6235597","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":2,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2198,732],[2233,732],[2233,762],[2198,762]],"region":{"top_left_x":2198,"top_left_y":731,"width":35,"height":32},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d67c894f2b014db9a93b4d7bf5905842","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"x","text_display":"x","cell_row":2,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":0.984375,"confidence_rate":0.997378715420626},{"cnt":[[431,775],[515,775],[515,812],[431,812]],"region":{"top_left_x":430,"top_left_y":775,"width":86,"height":37},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6661a8b34c544b0aea40b49c6633cf2","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"mRS \\({ }^{ j }\\)","text_display":"mRS \\({ }^{ j }\\)","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.5537109375,"confidence_rate":0.9693677885963878},{"cnt":[[1745,784],[1780,784],[1780,814],[1745,814]],"region":{"top_left_x":1745,"top_left_y":783,"width":36,"height":32},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac0332dab5154433be5628cb80afd980","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":3,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1964,784],[1990,784],[1990,814],[1964,814]],"region":{"top_left_x":1964,"top_left_y":783,"width":27,"height":32},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02c4b1c9438345deac4f37499a8fa6f8","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":3,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,831],[500,831],[500,862],[431,862]],"region":{"top_left_x":430,"top_left_y":831,"width":71,"height":31},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"440f00ae5b3e4dfdb1c323416e7361a6","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"GOS","text_display":"GOS","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1964,836],[1990,836],[1990,862],[1964,862]],"region":{"top_left_x":1964,"top_left_y":835,"width":27,"height":27},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4b8109bca8246ccb258b977d0b84320","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":4,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[418,873],[483,873],[483,914],[418,914]],"region":{"top_left_x":418,"top_left_y":872,"width":65,"height":42},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a59fafc644349aca409cacd8af15310","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"BI \\({ }^{ k }\\)","text_display":"BI \\({ }^{ k }\\)","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.5594921112060547,"confidence_rate":0.9682523366870166},{"cnt":[[1964,883],[1990,883],[1990,914],[1964,914]],"region":{"top_left_x":1964,"top_left_y":883,"width":27,"height":31},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c77267f283bb401899192b52903cc41f","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":5,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,946],[546,946],[546,981],[431,981]],"region":{"top_left_x":430,"top_left_y":946,"width":116,"height":35},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e86d4841ef248c69805f4c56ba7a063","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"EQ-5D \\({ }^{ k }\\)","text_display":"EQ-5D \\({ }^{ k }\\)","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.87109375,"confidence_rate":0.9934498476721647},{"cnt":[[1964,953],[1990,953],[1990,983],[1964,983]],"region":{"top_left_x":1964,"top_left_y":952,"width":27,"height":32},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0c0a96588f149eaa5cb8e7ad3eecda8","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":6,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1009],[546,1009],[546,1044],[431,1044]],"region":{"top_left_x":430,"top_left_y":1009,"width":116,"height":35},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fea3b39ab0a40fb8621993bd395195e","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"CES-D \\({ }^{ k }\\)","text_display":"CES-D \\({ }^{ k }\\)","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.49560546875,"confidence_rate":0.9671251360274937},{"cnt":[[1964,1013],[1990,1013],[1990,1048],[1964,1048]],"region":{"top_left_x":1964,"top_left_y":1013,"width":27,"height":35},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf3ffe4a845c45c3aae6daf87e147bec","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":7,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":0.56982421875,"confidence_rate":0.9105213856220216},{"cnt":[[431,1061],[546,1061],[546,1093],[431,1093]],"region":{"top_left_x":430,"top_left_y":1060,"width":116,"height":34},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e2a0a0c71d7d487385c697791ff7c0b6","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"SIS-16 \\({ }^{ k }\\)","text_display":"SIS-16 \\({ }^{ k }\\)","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.822265625,"confidence_rate":0.991144362771702},{"cnt":[[1964,1067],[1990,1067],[1990,1102],[1964,1102]],"region":{"top_left_x":1964,"top_left_y":1067,"width":27,"height":36},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0e6b68ba9594214a426db6c79c99ca7","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":8,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1111],[738,1111],[738,1150],[431,1150]],"region":{"top_left_x":430,"top_left_y":1110,"width":309,"height":40},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"41db54148cae410f93acb078ca1ebd69","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Cognitive assessment \\({ }^{1}\\)","text_display":"Cognitive assessment \\({ }^{1}\\)","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.5107421875,"confidence_rate":0.9798455582297309},{"cnt":[[1964,1117],[1990,1117],[1990,1154],[1964,1154]],"region":{"top_left_x":1964,"top_left_y":1117,"width":27,"height":38},"line":83,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02db14a7b17343308bdaf0f24c4b5062","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":9,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1165],[656,1165],[656,1202],[431,1202]],"region":{"top_left_x":430,"top_left_y":1164,"width":227,"height":38},"line":84,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a37a444221d4876a9ad1be553d980aa","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Waking speed \\({ }^{\\text {m }}\\)","text_display":"Waking speed \\({ }^{\\text {m }}\\)","cell_row":10,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9951221942901611,"confidence_rate":0.9998370219146363},{"cnt":[[1964,1169],[1990,1169],[1990,1206],[1964,1206]],"region":{"top_left_x":1964,"top_left_y":1169,"width":27,"height":38},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"293a01f06ebe47f9994231befb99231a","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":10,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1217],[777,1217],[777,1245],[431,1245]],"region":{"top_left_x":430,"top_left_y":1216,"width":348,"height":30},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0fda3d47f1643cf816620cf658f9370","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Concomitant medications \\({ }^{\\text {n }}\\)","text_display":"Concomitant medications \\({ }^{\\text {n }}\\)","cell_row":11,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9892578125,"confidence_rate":0.9997366127083595},{"cnt":[[925,1217],[959,1217],[959,1247],[925,1247]],"region":{"top_left_x":924,"top_left_y":1216,"width":36,"height":32},"line":87,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c004f74e2274b9b803d91a6844f69d6","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":11,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1340,1217],[1366,1217],[1366,1247],[1340,1247]],"region":{"top_left_x":1340,"top_left_y":1216,"width":27,"height":32},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0c76ba8d37e34308843ee959bf50586d","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":11,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1544,1217],[1570,1217],[1570,1247],[1544,1247]],"region":{"top_left_x":1544,"top_left_y":1216,"width":27,"height":32},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40abdeb62c064b2cabd90befcab5a896","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":11,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1745,1217],[1780,1217],[1780,1247],[1745,1247]],"region":{"top_left_x":1745,"top_left_y":1216,"width":36,"height":32},"line":90,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4611eadf3aa743659a480dbe982032d1","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":11,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1964,1217],[1990,1217],[1990,1247],[1964,1247]],"region":{"top_left_x":1964,"top_left_y":1216,"width":27,"height":32},"line":91,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f8a4cbe44a741bd9f7950c08a6f8881","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":11,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2198,1217],[2233,1217],[2233,1247],[2198,1247]],"region":{"top_left_x":2198,"top_left_y":1216,"width":35,"height":32},"line":92,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d6168fe7d6e42238087df7023cebb2e","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":11,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":0.99755859375,"confidence_rate":0.999592684418561},{"cnt":[[431,1269],[771,1269],[771,1301],[431,1301]],"region":{"top_left_x":430,"top_left_y":1268,"width":341,"height":34},"line":93,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"54e66c869d4f4b4ca068f5a9ac7a461f","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Assessment of pregnancy","text_display":"Assessment of pregnancy","cell_row":12,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1745,1269],[1780,1269],[1780,1299],[1745,1299]],"region":{"top_left_x":1745,"top_left_y":1268,"width":36,"height":32},"line":94,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bec3ff15e224847afdbc0d378bb7bd9","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":12,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1317],[645,1317],[645,1347],[431,1347]],"region":{"top_left_x":430,"top_left_y":1316,"width":216,"height":31},"line":95,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10c84fc869694fe2832438b626bf78e4","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"Adverse event \\({ }^{\\circ}\\)","text_display":"Adverse event \\({ }^{\\circ}\\)","cell_row":13,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999812155418875},{"cnt":[[925,1321],[959,1321],[959,1349],[925,1349]],"region":{"top_left_x":924,"top_left_y":1320,"width":36,"height":30},"line":96,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e824590d24024d00a014bb8ecc05144a","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":13,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1340,1321],[1366,1321],[1366,1349],[1340,1349]],"region":{"top_left_x":1340,"top_left_y":1320,"width":27,"height":30},"line":97,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"868e8dfc77d747c98f8816084d26016a","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":13,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1544,1321],[1570,1321],[1570,1349],[1544,1349]],"region":{"top_left_x":1544,"top_left_y":1320,"width":27,"height":30},"line":98,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ad60fb99a394b0ca1a9255d78667c8e","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":13,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1745,1321],[1780,1321],[1780,1349],[1745,1349]],"region":{"top_left_x":1745,"top_left_y":1320,"width":36,"height":30},"line":99,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a89f0bd4127b47c7b0b01ac647d57904","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":13,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1964,1321],[1990,1321],[1990,1349],[1964,1349]],"region":{"top_left_x":1964,"top_left_y":1320,"width":27,"height":30},"line":100,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b1646740bb6d44c6bf832e8a3c70b49c","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":13,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2198,1321],[2233,1321],[2233,1349],[2198,1349]],"region":{"top_left_x":2198,"top_left_y":1320,"width":35,"height":30},"line":101,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5bd5873004f240cabdfa93961c0128c6","type":"simple_cell","conversion_output":false,"parent_id":"107a27022801431c9187297b4950614d","text":"X","text_display":"X","cell_row":13,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999186032298787},{"cnt":[[434,1366],[2279,1366],[2279,1403],[434,1403]],"region":{"top_left_x":433,"top_left_y":1366,"width":1847,"height":37},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad79a6c6a3b4459c97bebf11bdd1d6a7","type":"text","conversion_output":true,"text":"BI = Barthel Index; BNT =Boston Naming Test; CES-D = Centers for Epidemiologic Studies, Depression; CT =computed tomography; DW MRI=","text_display":"\n\nBI = Barthel Index; BNT =Boston Naming Test; CES-D = Centers for Epidemiologic Studies, Depression; CT =computed tomography; DW MRI=","confidence":0.9566249451600015,"confidence_rate":0.9996763744862229},{"cnt":[[464,1401],[2316,1401],[2316,1439],[464,1439]],"region":{"top_left_x":464,"top_left_y":1400,"width":1853,"height":40},"line":103,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0cb47e0dac5d4b5f8bfae0c9c1d2c9f0","type":"text","conversion_output":true,"text":"diffusion-weighted MRI; European Quality of Life = EQ-5D; FLAIR = fluid-attenuated inversion recovery; GOS = Glasgow Outcome Scale; GRE=","text_display":" diffusion-weighted MRI; European Quality of Life = EQ-5D; FLAIR = fluid-attenuated inversion recovery; GOS = Glasgow Outcome Scale; GRE=","confidence":0.9980480668600649,"confidence_rate":0.9999861430701639},{"cnt":[[464,1435],[2163,1435],[2163,1474],[464,1474]],"region":{"top_left_x":464,"top_left_y":1435,"width":1700,"height":39},"line":104,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04024f226fa846c1b9014a46250c46d1","type":"text","conversion_output":true,"text":"gradient echo; HVLT-R=Hopkins Verbal Learning Test-Revised; ICH = intracranial hemorrhage; INR= international normalized ratio;","text_display":" gradient echo; HVLT-R=Hopkins Verbal Learning Test-Revised; ICH = intracranial hemorrhage; INR= international normalized ratio;","confidence":0.6186184512491764,"confidence_rate":0.996368227625533},{"cnt":[[464,1470],[2202,1470],[2202,1508],[464,1508]],"region":{"top_left_x":464,"top_left_y":1469,"width":1739,"height":40},"line":105,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ecae50fcd5a74da2bdd9691d445ce51b","type":"text","conversion_output":true,"text":"MRI=magnetic resonance imaging; mRS modified Rankin Scale; NIHSS= NIH Stroke Scale; Stroke Impact Scale-16= SIS-16; SWMRI=","text_display":" MRI=magnetic resonance imaging; mRS modified Rankin Scale; NIHSS= NIH Stroke Scale; Stroke Impact Scale-16= SIS-16; SWMRI=","confidence":0.985358476638794,"confidence_rate":0.9998838668357523},{"cnt":[[464,1504],[1437,1504],[1437,1545],[464,1545]],"region":{"top_left_x":464,"top_left_y":1503,"width":974,"height":42},"line":106,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9fb93e9ff39a49368cda98b83afdad98","type":"text","conversion_output":true,"text":"suscept bility-weighted MRI; WAIS III =Wechsler Adult Intelligence Scale III.","text_display":" suscept bility-weighted MRI; WAIS III =Wechsler Adult Intelligence Scale III.","confidence":0.9990234375,"confidence_rate":0.9999880849533282},{"cnt":[[434,1538],[1033,1538],[1033,1583],[434,1583]],"region":{"top_left_x":433,"top_left_y":1538,"width":601,"height":46},"line":107,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a71874862d04ac0bc4493142f2cd91d","type":"text","conversion_output":true,"text":"\\({ }^{\\text {a }}\\) Includes smoking history and stroke history.","text_display":"\n\\({ }^{\\text {a }}\\) Includes smoking history and stroke history.","confidence":0.83642578125,"confidence_rate":0.9971232186653929},{"cnt":[[434,1577],[2297,1577],[2297,1624],[434,1624]],"region":{"top_left_x":433,"top_left_y":1576,"width":1864,"height":49},"line":108,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9dee4e2eb74648aaa578dc4f9b29b6c6","type":"text","conversion_output":true,"text":"\\({ }^{b}\\) A partial neurological examination is to be performed for each patient. The NIHSS will be a component of the neurological examination and will","text_display":"\n\\({ }^{b}\\) A partial neurological examination is to be performed for each patient. The NIHSS will be a component of the neurological examination and will","confidence":0.84228515625,"confidence_rate":0.9988932795982541},{"cnt":[[464,1620],[2310,1620],[2310,1661],[464,1661]],"region":{"top_left_x":464,"top_left_y":1619,"width":1846,"height":42},"line":109,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0464747096934434b833d3359ae28516","type":"text","conversion_output":true,"text":"be performed only by practitioners who are certified to perform an NIHSS assessment. Additional, or supplemental, neurological exams will also","text_display":" be performed only by practitioners who are certified to perform an NIHSS assessment. Additional, or supplemental, neurological exams will also","confidence":0.99951171875,"confidence_rate":0.9999966775531512},{"cnt":[[464,1654],[1772,1654],[1772,1695],[464,1695]],"region":{"top_left_x":464,"top_left_y":1654,"width":1309,"height":42},"line":110,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e655c01eb9be4d4bada29560e782bab2","type":"text","conversion_output":true,"text":"be performed, including assessment of mental status, cranial nerves, motor function and coordination.","text_display":" be performed, including assessment of mental status, cranial nerves, motor function and coordination.","confidence":1,"confidence_rate":1},{"cnt":[[434,1757],[1205,1757],[1205,1798],[434,1798]],"region":{"top_left_x":433,"top_left_y":1757,"width":773,"height":42},"line":111,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0835624a82c4c4fa67178471f3aca0c","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,1796],[604,1796],[604,1828],[434,1828]],"region":{"top_left_x":433,"top_left_y":1796,"width":171,"height":33},"line":112,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"295144285f6b4affaff44999b4b71647","type":"page_info","conversion_output":false,"text":"40/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,1796],[1184,1796],[1184,1828],[1044,1828]],"region":{"top_left_x":1044,"top_left_y":1796,"width":140,"height":33},"line":113,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90e7a4b0aa98445facf2b1b6fb093e6f","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,1946],[1418,1946],[1418,1992],[370,1992]],"region":{"top_left_x":369,"top_left_y":1946,"width":1049,"height":46},"line":114,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0aae878ea4794c3480208a431f55f80b","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9985356330871582,"confidence_rate":0.9999774550211274},{"cnt":[[370,1985],[694,1985],[694,2017],[370,2017]],"region":{"top_left_x":369,"top_left_y":1985,"width":325,"height":33},"line":115,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41a67f899c1841c59b267d01868817fe","type":"page_info","conversion_output":false,"text":"801/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-42","page":42,"lines":[{"cnt":[[419,434],[2331,434],[2331,677],[419,677]],"region":{"top_left_x":418,"top_left_y":433,"width":1914,"height":244},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc9641ccc0f440d7ab949bffbe0f17fe","type":"table","conversion_output":true,"children_ids":["12f7334e952d4415a2fe146aebb4f9a2","d945fb097b4646b09a3468029867aee1","fc3fc86aca324ee8bb20f2c4ad5de404","db6224c4521d44cb92c3c6c250e231dc","b7efb6d49aa944aa94a972db99debd95","8b19b23ed3804abda22c6cbb0f3d8234","600828964c8f45adbb6a5c535f38b6e4","989056f64d5f4a4e91bc1469126889a4","52256dd5546647a0a6b0ee9cba829878","e7dfd042ccca46e591501d363f5adaa5","fa157c80e091412798c0a58857db1d2a","2b3f1a3cf3414594936699cd930fb130","b8b6866f5eb140b8922c87b1f6cfeadb","8db66fcbfd1f4be98860d2d276e914cc","2029691cc85a4a41a5d49cf80efe2929","c0ecdfedeba54e55a049408f55d4981e","733fea63c3b543b985caeebd862c87bc"],"text":"\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4) & 90 Days ( \\(\\pm 14\\) Days)/ Study Completion Visit (Visit 5) & Early Discontinuation (Phone call if possible) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|l|l|}\n\\hline ASSESSMENTS & Screening and Baseline (Visit 1) & Study Drug Administration & 22-36 Hours from Start of Study Drug Administration (Visit 2) & Day 5 (or Discharge if Sooner) (Visit 3) & 30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4) & 90 Days ( \\(\\pm 14\\) Days)/ Study Completion Visit (Visit 5) & Early Discontinuation (Phone call if possible) \\\\\n\\hline\n\\end{tabular}","confidence":0.6308350563049316,"confidence_rate":0.9988216964438291},{"cnt":[[507,433],[756,433],[756,678],[507,678]],"region":{"top_left_x":506,"top_left_y":433,"width":250,"height":245},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12f7334e952d4415a2fe146aebb4f9a2","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[845,433],[1046,433],[1046,678],[845,678]],"region":{"top_left_x":844,"top_left_y":433,"width":202,"height":245},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d945fb097b4646b09a3468029867aee1","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[1050,433],[1243,433],[1243,678],[1050,678]],"region":{"top_left_x":1050,"top_left_y":433,"width":194,"height":245},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc3fc86aca324ee8bb20f2c4ad5de404","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[1254,433],[1447,433],[1447,678],[1254,678]],"region":{"top_left_x":1253,"top_left_y":433,"width":194,"height":245},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"db6224c4521d44cb92c3c6c250e231dc","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[1462,433],[1652,433],[1652,678],[1462,678]],"region":{"top_left_x":1461,"top_left_y":433,"width":192,"height":245},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7efb6d49aa944aa94a972db99debd95","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[1678,433],[1841,433],[1841,678],[1678,678]],"region":{"top_left_x":1678,"top_left_y":433,"width":163,"height":245},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8b19b23ed3804abda22c6cbb0f3d8234","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[1893,433],[2062,433],[2062,678],[1893,678]],"region":{"top_left_x":1892,"top_left_y":433,"width":170,"height":245},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"600828964c8f45adbb6a5c535f38b6e4","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[2101,433],[2317,433],[2317,678],[2101,678]],"region":{"top_left_x":2100,"top_left_y":433,"width":218,"height":245},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"989056f64d5f4a4e91bc1469126889a4","type":"table_column","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[418,438],[2334,436],[2335,669],[418,671]],"region":{"top_left_x":417,"top_left_y":436,"width":1918,"height":236},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52256dd5546647a0a6b0ee9cba829878","type":"table_row","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"","text_display":""},{"cnt":[[509,533],[754,533],[754,574],[509,574]],"region":{"top_left_x":508,"top_left_y":532,"width":246,"height":42},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e7dfd042ccca46e591501d363f5adaa5","type":"simple_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","text":"ASSESSMENTS","text_display":"ASSESSMENTS","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[847,502],[1039,502],[1039,613],[847,613]],"region":{"top_left_x":846,"top_left_y":502,"width":194,"height":111},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa157c80e091412798c0a58857db1d2a","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["22670a43a61c43ee82521c9466dc1428","16781f0ea18e48cc8f8a7be1ae1bcb87","aa6a31ce9dc948dfbc05538c3cf25f96"],"text":"Screening and Baseline (Visit 1)","text_display":"Screening and Baseline (Visit 1)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[847,504],[1039,504],[1039,539],[847,539]],"region":{"top_left_x":846,"top_left_y":504,"width":194,"height":36},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22670a43a61c43ee82521c9466dc1428","type":"text","conversion_output":false,"parent_id":"fa157c80e091412798c0a58857db1d2a","text":"Screening and","text_display":"Screening and","confidence":1,"confidence_rate":1},{"cnt":[[886,541],[1001,541],[1001,569],[886,569]],"region":{"top_left_x":885,"top_left_y":541,"width":116,"height":29},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16781f0ea18e48cc8f8a7be1ae1bcb87","type":"text","conversion_output":false,"parent_id":"fa157c80e091412798c0a58857db1d2a","text":"Baseline","text_display":" Baseline","confidence":1,"confidence_rate":1},{"cnt":[[890,574],[996,574],[996,608],[890,608]],"region":{"top_left_x":890,"top_left_y":573,"width":107,"height":36},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aa6a31ce9dc948dfbc05538c3cf25f96","type":"text","conversion_output":false,"parent_id":"fa157c80e091412798c0a58857db1d2a","text":"(Visit 1)","text_display":" (Visit 1)","confidence":1,"confidence_rate":1},{"cnt":[[1050,520],[1245,520],[1245,591],[1050,591]],"region":{"top_left_x":1050,"top_left_y":519,"width":196,"height":73},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b3f1a3cf3414594936699cd930fb130","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["059a1807d1d94f26aef3ccb5d90b5502","9e55165f9f7947feaeb7cb5518be7de9"],"text":"Study Drug Administration","text_display":"Study Drug Administration","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1072,522],[1221,522],[1221,556],[1072,556]],"region":{"top_left_x":1071,"top_left_y":521,"width":151,"height":36},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"059a1807d1d94f26aef3ccb5d90b5502","type":"text","conversion_output":false,"parent_id":"2b3f1a3cf3414594936699cd930fb130","text":"Study Drug","text_display":"Study Drug","confidence":1,"confidence_rate":1},{"cnt":[[1052,559],[1241,559],[1241,587],[1052,587]],"region":{"top_left_x":1052,"top_left_y":558,"width":189,"height":29},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9e55165f9f7947feaeb7cb5518be7de9","type":"text","conversion_output":false,"parent_id":"2b3f1a3cf3414594936699cd930fb130","text":"Administration","text_display":" Administration","confidence":1,"confidence_rate":1},{"cnt":[[1254,450],[1447,450],[1447,665],[1254,665]],"region":{"top_left_x":1253,"top_left_y":450,"width":194,"height":215},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8b6866f5eb140b8922c87b1f6cfeadb","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["f1888f2e51d44d5da3c31e4ebaa0d978","8989b830cb3c4dcf894823fe2a46acca","15cbf88d39c34dbd8c042cc489b7664b","56271473093f4892bdb60187581caac3","708c9e86d0d44dd1a13df47dc7779a96","9f306c0feac846ce865b5d98a6c75974"],"text":"22-36 Hours from Start of Study Drug Administration (Visit 2)","text_display":"22-36 Hours from Start of Study Drug Administration (Visit 2)","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1306,452],[1397,452],[1397,485],[1306,485]],"region":{"top_left_x":1305,"top_left_y":452,"width":92,"height":33},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1888f2e51d44d5da3c31e4ebaa0d978","type":"text","conversion_output":false,"parent_id":"b8b6866f5eb140b8922c87b1f6cfeadb","text":"22-36","text_display":"22-36","confidence":1,"confidence_rate":1},{"cnt":[[1276,489],[1425,489],[1425,517],[1276,517]],"region":{"top_left_x":1275,"top_left_y":489,"width":150,"height":29},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8989b830cb3c4dcf894823fe2a46acca","type":"text","conversion_output":false,"parent_id":"b8b6866f5eb140b8922c87b1f6cfeadb","text":"Hours from","text_display":" Hours from","confidence":1,"confidence_rate":1},{"cnt":[[1297,524],[1408,524],[1408,552],[1297,552]],"region":{"top_left_x":1297,"top_left_y":523,"width":111,"height":30},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15cbf88d39c34dbd8c042cc489b7664b","type":"text","conversion_output":false,"parent_id":"b8b6866f5eb140b8922c87b1f6cfeadb","text":"Start of","text_display":" Start of","confidence":1,"confidence_rate":1},{"cnt":[[1276,559],[1425,559],[1425,591],[1276,591]],"region":{"top_left_x":1275,"top_left_y":558,"width":150,"height":34},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56271473093f4892bdb60187581caac3","type":"text","conversion_output":false,"parent_id":"b8b6866f5eb140b8922c87b1f6cfeadb","text":"Study Drug","text_display":" Study Drug","confidence":1,"confidence_rate":1},{"cnt":[[1256,593],[1444,593],[1444,621],[1256,621]],"region":{"top_left_x":1256,"top_left_y":593,"width":189,"height":29},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"708c9e86d0d44dd1a13df47dc7779a96","type":"text","conversion_output":false,"parent_id":"b8b6866f5eb140b8922c87b1f6cfeadb","text":"Administration","text_display":" Administration","confidence":1,"confidence_rate":1},{"cnt":[[1302,628],[1403,628],[1403,660],[1302,660]],"region":{"top_left_x":1301,"top_left_y":627,"width":103,"height":34},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f306c0feac846ce865b5d98a6c75974","type":"text","conversion_output":false,"parent_id":"b8b6866f5eb140b8922c87b1f6cfeadb","text":"(Visit 2)","text_display":" (Visit 2)","confidence":1,"confidence_rate":1},{"cnt":[[1462,485],[1650,485],[1650,630],[1462,630]],"region":{"top_left_x":1461,"top_left_y":484,"width":190,"height":147},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8db66fcbfd1f4be98860d2d276e914cc","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["e8a7541df32742b39d9724a85cdb670b","7db5fb9d37cf4ffd8d97395749a146c1","357ae678544c4357a62d279b3724d250","fe718d55a6734c18818a5d4dcc3bd088"],"text":"Day 5 (or Discharge if Sooner) (Visit 3)","text_display":"Day 5 (or Discharge if Sooner) (Visit 3)","cell_row":0,"cell_column":4,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999864300969632},{"cnt":[[1514,489],[1600,489],[1600,524],[1514,524]],"region":{"top_left_x":1513,"top_left_y":489,"width":88,"height":35},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8a7541df32742b39d9724a85cdb670b","type":"text","conversion_output":false,"parent_id":"8db66fcbfd1f4be98860d2d276e914cc","text":"Day 5","text_display":"Day 5","confidence":1,"confidence_rate":1},{"cnt":[[1464,524],[1646,524],[1646,556],[1464,556]],"region":{"top_left_x":1463,"top_left_y":523,"width":183,"height":34},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7db5fb9d37cf4ffd8d97395749a146c1","type":"text","conversion_output":false,"parent_id":"8db66fcbfd1f4be98860d2d276e914cc","text":"(or Discharge","text_display":" (or Discharge","confidence":0.9990234375,"confidence_rate":0.9999457214926967},{"cnt":[[1488,559],[1622,559],[1622,591],[1488,591]],"region":{"top_left_x":1487,"top_left_y":558,"width":136,"height":34},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"357ae678544c4357a62d279b3724d250","type":"text","conversion_output":false,"parent_id":"8db66fcbfd1f4be98860d2d276e914cc","text":"if Sooner)","text_display":" if Sooner)","confidence":1,"confidence_rate":1},{"cnt":[[1503,593],[1607,593],[1607,626],[1503,626]],"region":{"top_left_x":1502,"top_left_y":593,"width":105,"height":33},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe718d55a6734c18818a5d4dcc3bd088","type":"text","conversion_output":false,"parent_id":"8db66fcbfd1f4be98860d2d276e914cc","text":"(Visit 3)","text_display":" (Visit 3)","confidence":1,"confidence_rate":1},{"cnt":[[1678,485],[1836,485],[1836,630],[1678,630]],"region":{"top_left_x":1678,"top_left_y":484,"width":159,"height":147},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2029691cc85a4a41a5d49cf80efe2929","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["2adf2751c29c4cc2836e5797fd793eaf","e8a25fda852440f085eafc4bb5686d12","3f6a1c1df4f243988db3e1a0ef2d5533","6eabcbdd4b5a4f6987fc6be5487962b2"],"text":"30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4)","text_display":"30 Days ( \\(\\pm 7\\) Days) Phone Call (Visit 4)","cell_row":0,"cell_column":5,"cell_row_span":1,"cell_col_span":1,"confidence":0.6691818237304688,"confidence_rate":0.9944363752805303},{"cnt":[[1702,489],[1815,489],[1815,522],[1702,522]],"region":{"top_left_x":1702,"top_left_y":489,"width":113,"height":33},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2adf2751c29c4cc2836e5797fd793eaf","type":"text","conversion_output":false,"parent_id":"2029691cc85a4a41a5d49cf80efe2929","text":"30 Days","text_display":"30 Days","confidence":1,"confidence_rate":1},{"cnt":[[1689,524],[1830,524],[1830,556],[1689,556]],"region":{"top_left_x":1689,"top_left_y":523,"width":141,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e8a25fda852440f085eafc4bb5686d12","type":"text","conversion_output":false,"parent_id":"2029691cc85a4a41a5d49cf80efe2929","text":"( \\(\\pm 7\\) Days)","text_display":" ( \\(\\pm 7\\) Days)","confidence":0.6691818237304688,"confidence_rate":0.9779305367364026},{"cnt":[[1683,559],[1836,559],[1836,587],[1683,587]],"region":{"top_left_x":1682,"top_left_y":558,"width":155,"height":29},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f6a1c1df4f243988db3e1a0ef2d5533","type":"text","conversion_output":false,"parent_id":"2029691cc85a4a41a5d49cf80efe2929","text":"Phone Call","text_display":" Phone Call","confidence":1,"confidence_rate":1},{"cnt":[[1704,593],[1815,593],[1815,626],[1704,626]],"region":{"top_left_x":1704,"top_left_y":593,"width":111,"height":33},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6eabcbdd4b5a4f6987fc6be5487962b2","type":"text","conversion_output":false,"parent_id":"2029691cc85a4a41a5d49cf80efe2929","text":"(Visit 4)","text_display":" (Visit 4)","confidence":1,"confidence_rate":1},{"cnt":[[1893,450],[2062,450],[2062,663],[1893,663]],"region":{"top_left_x":1892,"top_left_y":450,"width":170,"height":213},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c0ecdfedeba54e55a049408f55d4981e","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["8687b7b5373d42549bfeadc61935c5ad","16e15167c038493c89531751ec774796","31aa64a0a653462fa8c8c8084a2bba8b","98d27fa8129645409d516379264062d6","6e5a17ff8b6b4841be8f9ede917d4c13","324219e0865547b68e3a40e16f207274"],"text":"90 Days ( \\(\\pm 14\\) Days)/ Study Completion Visit (Visit 5)","text_display":"90 Days ( \\(\\pm 14\\) Days)/ Study Completion Visit (Visit 5)","cell_row":0,"cell_column":6,"cell_row_span":1,"cell_col_span":1,"confidence":0.6308350563049316,"confidence_rate":0.9961681034325185},{"cnt":[[1919,455],[2031,455],[2031,487],[1919,487]],"region":{"top_left_x":1918,"top_left_y":454,"width":114,"height":34},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8687b7b5373d42549bfeadc61935c5ad","type":"text","conversion_output":false,"parent_id":"c0ecdfedeba54e55a049408f55d4981e","text":"90 Days","text_display":"90 Days","confidence":1,"confidence_rate":1},{"cnt":[[1895,489],[2059,489],[2059,522],[1895,522]],"region":{"top_left_x":1894,"top_left_y":489,"width":166,"height":33},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16e15167c038493c89531751ec774796","type":"text","conversion_output":false,"parent_id":"c0ecdfedeba54e55a049408f55d4981e","text":"( \\(\\pm 14\\) Days)/","text_display":" ( \\(\\pm 14\\) Days)/","confidence":0.6308350563049316,"confidence_rate":0.9772277499859623},{"cnt":[[1934,524],[2020,524],[2020,559],[1934,559]],"region":{"top_left_x":1933,"top_left_y":523,"width":88,"height":36},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31aa64a0a653462fa8c8c8084a2bba8b","type":"text","conversion_output":false,"parent_id":"c0ecdfedeba54e55a049408f55d4981e","text":"Study","text_display":" Study","confidence":1,"confidence_rate":1},{"cnt":[[1895,559],[2057,559],[2057,591],[1895,591]],"region":{"top_left_x":1894,"top_left_y":558,"width":164,"height":34},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98d27fa8129645409d516379264062d6","type":"text","conversion_output":false,"parent_id":"c0ecdfedeba54e55a049408f55d4981e","text":"Completion","text_display":" Completion","confidence":1,"confidence_rate":1},{"cnt":[[1943,593],[2012,593],[2012,624],[1943,624]],"region":{"top_left_x":1942,"top_left_y":593,"width":70,"height":31},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e5a17ff8b6b4841be8f9ede917d4c13","type":"text","conversion_output":false,"parent_id":"c0ecdfedeba54e55a049408f55d4981e","text":"Visit","text_display":" Visit","confidence":1,"confidence_rate":1},{"cnt":[[1921,628],[2031,628],[2031,660],[1921,660]],"region":{"top_left_x":1920,"top_left_y":627,"width":112,"height":34},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"324219e0865547b68e3a40e16f207274","type":"text","conversion_output":false,"parent_id":"c0ecdfedeba54e55a049408f55d4981e","text":"(Visit 5)","text_display":" (Visit 5)","confidence":1,"confidence_rate":1},{"cnt":[[2103,487],[2313,487],[2313,630],[2103,630]],"region":{"top_left_x":2102,"top_left_y":487,"width":211,"height":144},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"733fea63c3b543b985caeebd862c87bc","type":"complex_cell","conversion_output":false,"parent_id":"bc9641ccc0f440d7ab949bffbe0f17fe","children_ids":["cc787e9e2e6c45608b21b4ff185c1019","369e099db0b54f36bd14a5d0c94ae637","15e475c891a944e69f2e12eb9c511181","fa3f321e1fde4d41a1edcbd572d370f9"],"text":"Early Discontinuation (Phone call if possible)","text_display":"Early Discontinuation (Phone call if possible)","cell_row":0,"cell_column":7,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[2172,489],[2248,489],[2248,524],[2172,524]],"region":{"top_left_x":2172,"top_left_y":489,"width":76,"height":35},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc787e9e2e6c45608b21b4ff185c1019","type":"text","conversion_output":false,"parent_id":"733fea63c3b543b985caeebd862c87bc","text":"Early","text_display":"Early","confidence":1,"confidence_rate":1},{"cnt":[[2103,524],[2313,524],[2313,552],[2103,552]],"region":{"top_left_x":2102,"top_left_y":523,"width":211,"height":30},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"369e099db0b54f36bd14a5d0c94ae637","type":"text","conversion_output":false,"parent_id":"733fea63c3b543b985caeebd862c87bc","text":"Discontinuation","text_display":" Discontinuation","confidence":1,"confidence_rate":1},{"cnt":[[2120,559],[2300,559],[2300,591],[2120,591]],"region":{"top_left_x":2120,"top_left_y":558,"width":180,"height":34},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15e475c891a944e69f2e12eb9c511181","type":"text","conversion_output":false,"parent_id":"733fea63c3b543b985caeebd862c87bc","text":"(Phone call if","text_display":" (Phone call if","confidence":1,"confidence_rate":1},{"cnt":[[2146,593],[2269,593],[2269,626],[2146,626]],"region":{"top_left_x":2146,"top_left_y":593,"width":124,"height":33},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa3f321e1fde4d41a1edcbd572d370f9","type":"text","conversion_output":false,"parent_id":"733fea63c3b543b985caeebd862c87bc","text":"possible)","text_display":" possible)","confidence":1,"confidence_rate":1},{"cnt":[[434,675],[1609,675],[1609,715],[434,715]],"region":{"top_left_x":433,"top_left_y":674,"width":1177,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"901eb2be64964c2f9815fa7253753620","type":"text","conversion_output":true,"text":"\\({ }^{ c }\\) Includes pulse and systolic/diastolic blood pressure (while patient is in a supine position).","text_display":"\n\\({ }^{ c }\\) Includes pulse and systolic/diastolic blood pressure (while patient is in a supine position).","confidence":0.990234375,"confidence_rate":0.9999099708285726},{"cnt":[[432,713],[1721,713],[1721,758],[432,758]],"region":{"top_left_x":431,"top_left_y":713,"width":1290,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b67b5b3b23c64e70a50d64bbbae5c462","type":"text","conversion_output":true,"text":"\\({ }^{\\text {d }}\\) Complete blood count includes hemoglobin, hematocrit, white blood cell count, and platelet count.","text_display":"\n\\({ }^{\\text {d }}\\) Complete blood count includes hemoglobin, hematocrit, white blood cell count, and platelet count.","confidence":0.787109375,"confidence_rate":0.9979205297690072},{"cnt":[[434,756],[2292,756],[2292,797],[434,797]],"region":{"top_left_x":433,"top_left_y":756,"width":1860,"height":42},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f5e72edbdd94ad4aadb61f62b0bb8cd","type":"text","conversion_output":true,"text":"\\({ }^{ e }\\) Coagulation status includes INR values of \\(>1.7\\), activated partial thromboplastin time, patient or family report of patient currently taking an oral","text_display":"\n\\({ }^{ e }\\) Coagulation status includes INR values of \\(>1.7\\), activated partial thromboplastin time, patient or family report of patient currently taking an oral","confidence":0.7428011894226074,"confidence_rate":0.9982211836835823},{"cnt":[[464,795],[2292,795],[2292,831],[464,831]],"region":{"top_left_x":464,"top_left_y":794,"width":1829,"height":38},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0482365bb1f24a00a7d52ab7dd93d6a1","type":"text","conversion_output":true,"text":"anticoagulant (e.g., dabigatran, rivaroxaban, apixaban, edoxaban), or patient or family report of patient currently taking a low-molecular-weight","text_display":" anticoagulant (e.g., dabigatran, rivaroxaban, apixaban, edoxaban), or patient or family report of patient currently taking a low-molecular-weight","confidence":1,"confidence_rate":1},{"cnt":[[464,829],[1259,829],[1259,866],[464,866]],"region":{"top_left_x":464,"top_left_y":829,"width":795,"height":37},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90bab2b88792470095bb43a884c545a5","type":"text","conversion_output":true,"text":"heparin (e.g., dalteparin, enoxaparin) within the last 48 hours.","text_display":" heparin (e.g., dalteparin, enoxaparin) within the last 48 hours.","confidence":0.99951171875,"confidence_rate":0.9999932166827553},{"cnt":[[432,864],[2013,864],[2013,909],[432,909]],"region":{"top_left_x":431,"top_left_y":863,"width":1583,"height":46},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"805df62b7d144e77a9762da394414ad4","type":"text","conversion_output":true,"text":"\\({ }^{ f }\\) Pregnancy status will be determined in women of childbearing potential. Serum or urine pregnancy test can be collected.","text_display":"\n\\({ }^{ f }\\) Pregnancy status will be determined in women of childbearing potential. Serum or urine pregnancy test can be collected.","confidence":0.99560546875,"confidence_rate":0.9999673767130033},{"cnt":[[434,907],[1390,907],[1390,947],[434,947]],"region":{"top_left_x":433,"top_left_y":906,"width":958,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"779a0b5242724ec5a488afa36e998c7d","type":"text","conversion_output":true,"text":"\\({ }^{ g }\\) Serum glucose (values of \\(<50 mg / dL\\) are contraindicated for alteplase).","text_display":"\n\\({ }^{ g }\\) Serum glucose (values of \\(<50 mg / dL\\) are contraindicated for alteplase).","confidence":0.9641805633436888,"confidence_rate":0.9996120253291116},{"cnt":[[434,945],[1403,945],[1403,986],[434,986]],"region":{"top_left_x":433,"top_left_y":945,"width":970,"height":42},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07b84c4c1310419093f9b6a944e42b1b","type":"text","conversion_output":true,"text":"\\({ }^{ h }\\) MRI or CT scan should be performed if any clinical findings suggest ICH.","text_display":"\n\\({ }^{ h }\\) MRI or CT scan should be performed if any clinical findings suggest ICH.","confidence":0.82861328125,"confidence_rate":0.9978658972499854},{"cnt":[[432,984],[1745,984],[1745,1029],[432,1029]],"region":{"top_left_x":431,"top_left_y":983,"width":1314,"height":47},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a3c3faab4124ca5b965539c0db4124d","type":"text","conversion_output":true,"text":"\\({ }^{\\text {i }}\\) NIHSS score should be assessed and recorded at the time of any clinical findings that suggest ICH.","text_display":"\n\\({ }^{\\text {i }}\\) NIHSS score should be assessed and recorded at the time of any clinical findings that suggest ICH.","confidence":0.6318111419677734,"confidence_rate":0.9960495069520309},{"cnt":[[430,1025],[1562,1025],[1562,1068],[430,1068]],"region":{"top_left_x":429,"top_left_y":1024,"width":1133,"height":44},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2001678e16e4855bc92f6946822ca10","type":"text","conversion_output":true,"text":"\\({ }^{\\text {j }}\\) The mRS may be performed by telephone, if necessary, for visits on Days 30 and 90.","text_display":"\n\\({ }^{\\text {j }}\\) The mRS may be performed by telephone, if necessary, for visits on Days 30 and 90.","confidence":0.6045821215957403,"confidence_rate":0.9950786422332032},{"cnt":[[434,1066],[2316,1066],[2316,1109],[434,1109]],"region":{"top_left_x":433,"top_left_y":1065,"width":1884,"height":44},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f5e5511596bd4716955df9fc71346b9d","type":"text","conversion_output":true,"text":"\\({ }^{ k }\\) The BI, CES-D, EQ-5D, and SIS-16 can be administered by phone interview if an in-person patient visit cannot be scheduled in the allotted time.","text_display":"\n\\({ }^{ k }\\) The BI, CES-D, EQ-5D, and SIS-16 can be administered by phone interview if an in-person patient visit cannot be scheduled in the allotted time.","confidence":0.9499087333679199,"confidence_rate":0.9996768486451434},{"cnt":[[432,1104],[2245,1104],[2245,1149],[432,1149]],"region":{"top_left_x":431,"top_left_y":1104,"width":1815,"height":46},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8cbe148d950d45278f2a7415b168fa6d","type":"text","conversion_output":true,"text":"\\({ }^{1}\\) Assessments include: Controlled Oral Word Association test; HVLT-R trials 1, 2, and 3; digit symbol coding from the WAIS III; Forward and","text_display":"\n\\({ }^{1}\\) Assessments include: Controlled Oral Word Association test; HVLT-R trials 1, 2, and 3; digit symbol coding from the WAIS III; Forward and","confidence":0.9960973262786865,"confidence_rate":0.9999739316129578},{"cnt":[[464,1147],[2307,1147],[2307,1184],[464,1184]],"region":{"top_left_x":464,"top_left_y":1147,"width":1844,"height":37},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce810f6fcfc3481cb941c96c50c35376","type":"text","conversion_output":true,"text":"Backward Digit Span test; Benton Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency (Animal Naming test);","text_display":" Backward Digit Span test; Benton Judgment of Line Orientation, form V; HVLT-R trial 4 and recognition; semantic fluency (Animal Naming test);","confidence":0.99951171875,"confidence_rate":0.9999967221496802},{"cnt":[[464,1182],[857,1182],[857,1218],[464,1218]],"region":{"top_left_x":464,"top_left_y":1181,"width":394,"height":38},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8adbb3b75e59418f8ae6a41ab281ecac","type":"text","conversion_output":true,"text":"and BNT (15-item short form).","text_display":" and BNT (15-item short form).","confidence":0.662109375,"confidence_rate":0.9879460463371843},{"cnt":[[434,1220],[2310,1220],[2310,1259],[434,1259]],"region":{"top_left_x":433,"top_left_y":1220,"width":1877,"height":39},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bfc9f66eb464e81a7ebf6359f5d2b70","type":"text","conversion_output":true,"text":"\\({ }^{m}\\) Assessment of wa king speed requires an in-person patient visit and is best combined with administration of the BI, CES-D, EQ-5D, and SIS-16.","text_display":"\n\\({ }^{m}\\) Assessment of wa king speed requires an in-person patient visit and is best combined with administration of the BI, CES-D, EQ-5D, and SIS-16.","confidence":0.9477791786193848,"confidence_rate":0.9996517896145977},{"cnt":[[434,1259],[2219,1259],[2219,1300],[434,1300]],"region":{"top_left_x":433,"top_left_y":1258,"width":1787,"height":42},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bbc6104a0d845069ea80868220d0a4e","type":"text","conversion_output":true,"text":"\\({ }^{ n }\\) Concomitant medications include any prescription medications or over-the-counter preparations used by the patient within 7 days prior to","text_display":"\n\\({ }^{ n }\\) Concomitant medications include any prescription medications or over-the-counter preparations used by the patient within 7 days prior to","confidence":0.6162834167480469,"confidence_rate":0.9968819787105632},{"cnt":[[464,1298],[604,1298],[604,1334],[464,1334]],"region":{"top_left_x":464,"top_left_y":1297,"width":140,"height":38},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b62ff192432483e8e68416db8448eaa","type":"text","conversion_output":true,"text":"screening.","text_display":" screening.","confidence":1,"confidence_rate":1},{"cnt":[[434,1334],[2288,1334],[2288,1377],[434,1377]],"region":{"top_left_x":433,"top_left_y":1334,"width":1856,"height":44},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bac0898c90145c2950b62650a16a6f1","type":"text","conversion_output":true,"text":"\\({ }^{\\text {o }}\\) Adverse event assessments will be performed during study drug administration; at \\(22-36\\) hours after study drug administration; on Days 5, 30,","text_display":"\n\\({ }^{\\text {o }}\\) Adverse event assessments will be performed during study drug administration; at \\(22-36\\) hours after study drug administration; on Days 5, 30,","confidence":0.532649879927038,"confidence_rate":0.9960952771449947},{"cnt":[[464,1373],[2224,1373],[2224,1412],[464,1412]],"region":{"top_left_x":464,"top_left_y":1372,"width":1760,"height":40},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b4246739e2aa45e89f8fbb63d719f4e0","type":"text","conversion_output":true,"text":"and 90 (may be done via telephone interview if necessary), and at early discontinuation. Refer to Section 5.3.1 (Adverse Event Reporting","text_display":" and 90 (may be done via telephone interview if necessary), and at early discontinuation. Refer to Section 5.3.1 (Adverse Event Reporting","confidence":1,"confidence_rate":1},{"cnt":[[464,1405],[797,1405],[797,1446],[464,1446]],"region":{"top_left_x":464,"top_left_y":1405,"width":334,"height":41},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d341d44bab454269ba74da583174a2dc","type":"text","conversion_output":true,"text":"Period) for further details.","text_display":" Period) for further details.","confidence":1,"confidence_rate":1},{"cnt":[[434,1757],[1205,1757],[1205,1798],[434,1798]],"region":{"top_left_x":433,"top_left_y":1757,"width":773,"height":42},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e80cc5d9e4841f1b60a507f7ef3a406","type":"section_header","conversion_output":false,"children_ids":["9d78a5071db04cfbaab4996f299efcf2"],"text":"","text_display":""},{"cnt":[[434,1762],[1201,1762],[1201,1794],[434,1794]],"region":{"top_left_x":433,"top_left_y":1761,"width":768,"height":33},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d78a5071db04cfbaab4996f299efcf2","type":"text","conversion_output":true,"parent_id":"1e80cc5d9e4841f1b60a507f7ef3a406","text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\n\\section*{Statistical Analysis Plan: Alteplase-Genentech USMA}","confidence":1,"confidence_rate":1},{"cnt":[[434,1796],[604,1796],[604,1828],[434,1828]],"region":{"top_left_x":433,"top_left_y":1796,"width":171,"height":33},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4358e4f0e2434f7e8e371d06e8ca8ed7","type":"text","conversion_output":true,"text":"41/ML29093","text_display":"\n\n41/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,1796],[1184,1796],[1184,1828],[1044,1828]],"region":{"top_left_x":1044,"top_left_y":1796,"width":140,"height":33},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"730189309e424607a5d5e4aa58670d3d","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,1946],[1420,1946],[1420,1992],[370,1992]],"region":{"top_left_x":369,"top_left_y":1946,"width":1052,"height":46},"line":72,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29061945b2814389bfa2a2304e40e212","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9980478286743164,"confidence_rate":0.9999699376934855},{"cnt":[[370,1985],[694,1985],[694,2017],[370,2017]],"region":{"top_left_x":369,"top_left_y":1985,"width":325,"height":33},"line":73,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d12cc7810b824c8abd8a33839df205ef","type":"page_info","conversion_output":false,"text":"802/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-43","page":43,"lines":[{"cnt":[[885,440],[1293,440],[1293,490],[885,490]],"region":{"top_left_x":885,"top_left_y":440,"width":409,"height":50},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7798877cc5054814b60290c75d6cffad","type":"figure_label","conversion_output":false,"text":"Figure 1 Study Flowchart","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[509,505],[1583,505],[1583,986],[509,986]],"region":{"top_left_x":509,"top_left_y":504,"width":1075,"height":483},"line":2,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"d1e21638ed544528a962dbae0df431f5","type":"diagram","conversion_output":true,"selected_labels":["7798877cc5054814b60290c75d6cffad"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1 Study Flowchart}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-43.jpg?height=483&width=1075&top_left_y=504&top_left_x=509}\n\\end{figure}"},{"cnt":[[436,999],[1689,999],[1689,1036],[436,1036]],"region":{"top_left_x":436,"top_left_y":999,"width":1253,"height":37},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"924c7e170096408db653f75e91acee07","type":"text","conversion_output":true,"text":"ASA = aspirin; CT= computed tomography; IV=intravenous; MRI= magnetic resonance imaging;","text_display":"\n\nASA = aspirin; CT= computed tomography; IV=intravenous; MRI= magnetic resonance imaging;","confidence":0.9044711174848313,"confidence_rate":0.998920959930387},{"cnt":[[438,1036],[1489,1036],[1489,1068],[438,1068]],"region":{"top_left_x":438,"top_left_y":1035,"width":1051,"height":33},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b734075540d4ea4b981f2d1f8d96162","type":"text","conversion_output":true,"text":"mRS \\(=\\) modified Rankin Scale; NIHSS \\(=\\) National Institutes of Health Stroke Scale.","text_display":" mRS \\(=\\) modified Rankin Scale; NIHSS \\(=\\) National Institutes of Health Stroke Scale.","confidence":0.7111576927849796,"confidence_rate":0.9962612802876948},{"cnt":[[434,2368],[1201,2368],[1201,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f89de2fe8504c3b99e917d67516936a","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[604,2402],[604,2438],[434,2438]],"region":{"top_left_x":433,"top_left_y":2401,"width":171,"height":38},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a7020cc01594f208d61ffb4fcce76e1","type":"page_info","conversion_output":false,"text":"42/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2438],[1044,2438]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":38},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7896622d87714461b797cf6d97d9434d","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d9c870d425342a6874252fbd9301ef8","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922046510095575,"confidence_rate":0.9998796089159951},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a6356f96f32449c83e5941ec2a6bbb6","type":"page_info","conversion_output":false,"text":"803/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-44","page":44,"lines":[{"cnt":[[883,438],[1291,438],[1291,526],[883,526]],"region":{"top_left_x":883,"top_left_y":438,"width":409,"height":89},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6efd3aa50cc4654b0834c26711725b3","type":"section_header","conversion_output":false,"children_ids":["8fb0ae07698048a3ab2a0fc864f767f1","fe2a66271baa45ab9ed94813bf127499"],"text":"","text_display":""},{"cnt":[[988,443],[1188,443],[1188,483],[988,483]],"region":{"top_left_x":988,"top_left_y":442,"width":201,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fb0ae07698048a3ab2a0fc864f767f1","type":"text","conversion_output":true,"parent_id":"f6efd3aa50cc4654b0834c26711725b3","text":"Appendix C","text_display":"\n\n\\section*{Appendix C","confidence":1,"confidence_rate":1},{"cnt":[[889,486],[1287,486],[1287,522],[889,522]],"region":{"top_left_x":889,"top_left_y":485,"width":398,"height":38},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe2a66271baa45ab9ed94813bf127499","type":"text","conversion_output":true,"parent_id":"f6efd3aa50cc4654b0834c26711725b3","text":"Randomization Scheme","text_display":" Randomization Scheme}","confidence":1,"confidence_rate":1},{"cnt":[[434,593],[879,593],[879,634],[434,634]],"region":{"top_left_x":433,"top_left_y":592,"width":446,"height":42},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"764a6efea1184677a720128ce08bb106","type":"text","conversion_output":true,"text":"Initialization of the algorithm:","text_display":"\n\nInitialization of the algorithm:","confidence":1,"confidence_rate":1},{"cnt":[[434,679],[1601,679],[1601,715],[434,715]],"region":{"top_left_x":433,"top_left_y":678,"width":1168,"height":38},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d00fd72562b4f5cb777d84a7bf0b255","type":"text","conversion_output":true,"text":"- Generate a randomization list for all sites such that half the sites receive","text_display":"\n- Generate a randomization list for all sites such that half the sites receive","confidence":1,"confidence_rate":1},{"cnt":[[486,722],[1695,722],[1695,763],[486,763]],"region":{"top_left_x":485,"top_left_y":721,"width":1211,"height":42},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7912d429f14d4cbd8e3ba07da2c0fa41","type":"text","conversion_output":true,"text":"Treatment Arm A, half the sites receive Treatment Arm B as the first treatment","text_display":" Treatment Arm A, half the sites receive Treatment Arm B as the first treatment","confidence":1,"confidence_rate":1},{"cnt":[[486,765],[1661,765],[1661,810],[486,810]],"region":{"top_left_x":485,"top_left_y":764,"width":1176,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0bf19e9ee8d4aab809a827b2a108166","type":"text","conversion_output":true,"text":"assignment. Need to ensure that as each SITE is activated there is balance","text_display":" assignment. Need to ensure that as each SITE is activated there is balance","confidence":1,"confidence_rate":1},{"cnt":[[486,808],[1695,808],[1695,851],[486,851]],"region":{"top_left_x":485,"top_left_y":807,"width":1211,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2635c945c3f7469788e4e0dcf32ed366","type":"text","conversion_output":true,"text":"between Treatment Arm A and Treatment Arm B after every \\(x\\) sites have been","text_display":" between Treatment Arm A and Treatment Arm B after every \\(x\\) sites have been","confidence":0.9951171875,"confidence_rate":0.9999395725372111},{"cnt":[[486,851],[1551,851],[1551,896],[486,896]],"region":{"top_left_x":485,"top_left_y":850,"width":1067,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f2d44c7ae704ac2b38374e72e93fcbd","type":"text","conversion_output":true,"text":"activated (ie., use permuted block randomization with block size of \\(x\\) )","text_display":" activated (ie., use permuted block randomization with block size of \\(x\\) )","confidence":0.9951193332672119,"confidence_rate":0.9999380700685848},{"cnt":[[434,915],[1622,915],[1622,960],[434,960]],"region":{"top_left_x":433,"top_left_y":915,"width":1190,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2896a0b81142410a8fa48022a835a947","type":"text","conversion_output":true,"text":"- At the time of drug supply receipt verification, obtain the first \"USE NEXT\"","text_display":"\n- At the time of drug supply receipt verification, obtain the first \"USE NEXT\"","confidence":1,"confidence_rate":1},{"cnt":[[486,958],[1674,958],[1674,1003],[486,1003]],"region":{"top_left_x":485,"top_left_y":958,"width":1189,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"39cf10d807d94cb2b9f60c2d2b2330ae","type":"text","conversion_output":true,"text":"treatment assignment sequentially from the pre-generated randomization list.","text_display":" treatment assignment sequentially from the pre-generated randomization list.","confidence":1,"confidence_rate":1},{"cnt":[[486,1001],[1674,1001],[1674,1046],[486,1046]],"region":{"top_left_x":485,"top_left_y":1001,"width":1189,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"86ac8c41f6c74304aa978ec73db415ff","type":"text","conversion_output":true,"text":"When the \"USE NEXT\" treatment assignment is used on a patient or wasted,","text_display":" When the \"USE NEXT\" treatment assignment is used on a patient or wasted,","confidence":1,"confidence_rate":1},{"cnt":[[486,1044],[1727,1044],[1727,1089],[486,1089]],"region":{"top_left_x":485,"top_left_y":1044,"width":1243,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a90854c30914f4daf210e4e56b64471","type":"text","conversion_output":true,"text":"then the next \"USE NEXT\" treatment assignment is according to the algorithm in","text_display":" then the next \"USE NEXT\" treatment assignment is according to the algorithm in","confidence":1,"confidence_rate":1},{"cnt":[[486,1087],[715,1087],[715,1132],[486,1132]],"region":{"top_left_x":485,"top_left_y":1087,"width":231,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"23057511ff5c49f7a2c5f48472f8c0c5","type":"text","conversion_output":true,"text":"Steps 1 and 2.","text_display":" Steps 1 and 2.","confidence":1,"confidence_rate":1},{"cnt":[[434,1179],[1738,1179],[1738,1222],[434,1222]],"region":{"top_left_x":433,"top_left_y":1179,"width":1306,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"105d50705adf4b53aacb21f935d5686c","type":"text","conversion_output":true,"text":"Note: If this assignment has not been done in time for the next patient's arrival to the","text_display":"\n\nNote: If this assignment has not been done in time for the next patient's arrival to the","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[434,1231],[1725,1231],[1725,1274],[434,1274]],"region":{"top_left_x":433,"top_left_y":1231,"width":1293,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8116523cb6124c7ab1431fe3767ec9c9","type":"text","conversion_output":true,"text":"site, then the new patient will be randomized by a fair coin flip. This will be achieved","text_display":" site, then the new patient will be randomized by a fair coin flip. This will be achieved","confidence":1,"confidence_rate":1},{"cnt":[[434,1283],[969,1283],[969,1326],[434,1326]],"region":{"top_left_x":433,"top_left_y":1282,"width":536,"height":44},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7231810606f454688eb4105124a7eb5","type":"text","conversion_output":true,"text":"by calling IWRS technical support.","text_display":" by calling IWRS technical support.","confidence":1,"confidence_rate":1},{"cnt":[[434,1371],[1725,1371],[1725,1414],[434,1414]],"region":{"top_left_x":433,"top_left_y":1370,"width":1293,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ce6de42dd2bb40e0a249563923e26bb1","type":"text","conversion_output":true,"text":"1. Identify the site for which the \"USE NEXT\" kits are to be assigned (Let \"j\" be the","text_display":"\n1. Identify the site for which the \"USE NEXT\" kits are to be assigned (Let \"j\" be the","confidence":0.9907369613647461,"confidence_rate":0.9998966030417578},{"cnt":[[494,1414],[707,1414],[707,1454],[494,1454]],"region":{"top_left_x":494,"top_left_y":1413,"width":213,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f396fa5c05a425782090679c3a994b1","type":"text","conversion_output":true,"text":"site number).","text_display":" site number).","confidence":1,"confidence_rate":1},{"cnt":[[434,1474],[1641,1474],[1641,1519],[434,1519]],"region":{"top_left_x":433,"top_left_y":1473,"width":1209,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5f6b66aef37746b18db919df8f925d7c","type":"text","conversion_output":true,"text":"2. Calculate the intermediate variables needed (see Table 4) and update the","text_display":"\n2. Calculate the intermediate variables needed (see Table 4) and update the","confidence":1,"confidence_rate":1},{"cnt":[[494,1521],[823,1521],[823,1562],[494,1562]],"region":{"top_left_x":494,"top_left_y":1521,"width":329,"height":41},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b895a8eb0aa545f8ad3f5e0299e2af83","type":"text","conversion_output":true,"text":"appropriate data set.","text_display":" appropriate data set.","confidence":0.96630859375,"confidence_rate":0.9986827129792077},{"cnt":[[434,1583],[1635,1583],[1635,1626],[434,1626]],"region":{"top_left_x":433,"top_left_y":1583,"width":1202,"height":44},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd84bebbcda14081a867246c170548ff","type":"text","conversion_output":true,"text":"3. Compare the appropriate intermediate variables to the specified threshold","text_display":"\n3. Compare the appropriate intermediate variables to the specified threshold","confidence":0.99951171875,"confidence_rate":0.9999939703823991},{"cnt":[[494,1629],[1158,1629],[1158,1669],[494,1669]],"region":{"top_left_x":494,"top_left_y":1628,"width":665,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"34f8ad7baaea49379ce2564655efaef2","type":"text","conversion_output":true,"text":"values, site first then overall (see Table 5).","text_display":" values, site first then overall (see Table 5).","confidence":1,"confidence_rate":1},{"cnt":[[432,1691],[1708,1691],[1708,1734],[432,1734]],"region":{"top_left_x":431,"top_left_y":1690,"width":1278,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a62373216354d548f5e9706fac0438b","type":"text","conversion_output":true,"text":"4. IWRS Service Provider will update the appropriate dataset with (a) USE NEXT","text_display":"\n4. IWRS Service Provider will update the appropriate dataset with (a) USE NEXT","confidence":0.99951171875,"confidence_rate":0.999994115673962},{"cnt":[[494,1732],[1671,1732],[1671,1777],[494,1777]],"region":{"top_left_x":494,"top_left_y":1731,"width":1178,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d24334c307f0426a8163625b7d0b696c","type":"text","conversion_output":true,"text":"numbers, (b) random number used by algorithm, (c) study-specific algorithm","text_display":" numbers, (b) random number used by algorithm, (c) study-specific algorithm","confidence":1,"confidence_rate":1},{"cnt":[[494,1777],[1126,1777],[1126,1820],[494,1820]],"region":{"top_left_x":494,"top_left_y":1776,"width":632,"height":44},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b83999b3c98d454695849f847249f128","type":"text","conversion_output":true,"text":"step at which treatment was determined.","text_display":" step at which treatment was determined.","confidence":1,"confidence_rate":1},{"cnt":[[434,1841],[1646,1841],[1646,1884],[434,1884]],"region":{"top_left_x":433,"top_left_y":1841,"width":1213,"height":44},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"efa28276ed7a421ea8ff9ea15a1b7a35","type":"text","conversion_output":true,"text":"5. When patients have been treated with study drug kits and registered in the","text_display":"\n5. When patients have been treated with study drug kits and registered in the","confidence":1,"confidence_rate":1},{"cnt":[[494,1884],[1644,1884],[1644,1927],[494,1927]],"region":{"top_left_x":494,"top_left_y":1884,"width":1150,"height":44},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d6ab61e2c814e098f3565ce8800e96f","type":"text","conversion_output":true,"text":"system, IWRS updates the enrolled numbers and USE NEXT kit numbers.","text_display":" system, IWRS updates the enrolled numbers and USE NEXT kit numbers.","confidence":1,"confidence_rate":1},{"cnt":[[434,1972],[1635,1972],[1635,2017],[434,2017]],"region":{"top_left_x":433,"top_left_y":1972,"width":1202,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76c0238f174843ed814c7bfbfeab48e6","type":"text","conversion_output":true,"text":"Figure 2 displays the randomization steps for the step-forward randomization.","text_display":"\n\nFigure 2 displays the randomization steps for the step-forward randomization.","confidence":0.99853515625,"confidence_rate":0.9999827540583306},{"cnt":[[434,2368],[1201,2368],[1201,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":38},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cb637017c0641d79a6b7c5a42b3d6bc","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[599,2402],[599,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2401,"width":167,"height":34},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"04870e466a01472583f91b7892ed75d5","type":"page_info","conversion_output":false,"text":"43/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":34},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"483545fffe814875b5fe4bc2be59a06f","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47c00a3769b641ec9dc06df672336e1c","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936649702746081,"confidence_rate":0.9999022327614051},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0db3e5e93864194b2ad9744624c7ef1","type":"page_info","conversion_output":false,"text":"804/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-45","page":45,"lines":[{"cnt":[[645,443],[1532,443],[1532,544],[645,544]],"region":{"top_left_x":644,"top_left_y":442,"width":888,"height":102},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9da4ed2efc6940bbbdc12a6400512c02","type":"figure_label","conversion_output":false,"children_ids":["e57ef0c8dbbd4d54bd136fd23641abb8","ca7c283deae44819ac80f33b8cd24d7b"],"text":"","text_display":""},{"cnt":[[1023,451],[1154,451],[1154,483],[1023,483]],"region":{"top_left_x":1022,"top_left_y":451,"width":132,"height":33},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e57ef0c8dbbd4d54bd136fd23641abb8","type":"text","conversion_output":false,"parent_id":"9da4ed2efc6940bbbdc12a6400512c02","text":"Table 4","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[653,498],[1528,498],[1528,539],[653,539]],"region":{"top_left_x":653,"top_left_y":498,"width":875,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca7c283deae44819ac80f33b8cd24d7b","type":"text","conversion_output":false,"parent_id":"9da4ed2efc6940bbbdc12a6400512c02","text":"Intermediate Variables for the Next Allocation Probability","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[432,554],[1745,554],[1745,1119],[432,1119]],"region":{"top_left_x":431,"top_left_y":554,"width":1314,"height":566},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"2432d35fc5d84c128c64483b77eeb6e8","type":"table","conversion_output":true,"children_ids":["888f04f9694b418da1211eee42ce4319","ce34e18ebdae41bfa69a2e3196019589","9da9141e2c6a4046a20e72d321a3a51e","f323e9a8cb79448aa6908be97e9b3a74","e52b0d7fc50d4486b2f5ea6424518000","12488d53cb51446788961c48a3fb7a2b","f0eeb8e19c614048be6d13a822355bf6","777dc1f9732c4753b5d0181e77471520","e98cd580b77743c687abccfb8c5cce10","5d2bf4c15b8342bbbaba61951b8f34ae","1cdde8b4402e4e88998a03aebd41ee40","14a1e14428874adda3897a938734c71a","92862edfdbcd4ea498ee8334a67f518a","a3c9b8ba254e40268b63d1ddaa1832dd","d399d7b7128242d9914e496f24267f33","9c2b74a5317a4daca396fd06a0104ad3","8e785ecf9d4d4660968371cb03817142","7ff783c896c7427f9ad24e163d3744c6","cec7db164c5943fab7ce664ebc849c59","84c7c8281e9b49e3b7a2ab0f2a7f77ef","2d1fcba94ca64084a3a8f98d079c40d1","20d142d90478468fbb6ea9490e5fb9ce","8e2af99488f443dfad2e349bcf30acb5","72289997a9a3425baecd3b5b0b952a1b","f0d0363e4d854eee8591edb71560edf9","3145bf080e7346d282835c885f9d0dde","4cce9fee125f419c91b9a9bba14c21c4","9721b0aed8a547e28ea155f8296d79ae","cf4453a9c7104a1a806466fefc2c7da2"],"selected_labels":["9da4ed2efc6940bbbdc12a6400512c02"],"text":"\\begin{tabular}{|l|l|}\n\\hline Variable & Definition \\\\\n\\hline S_j_A & Number of enrolled patients in Treatment Arm A at Site j \\\\\n\\hline S_j_B & Number of enrolled patients in Treatment Arm B at Site j \\\\\n\\hline S_j_AB & Imbalance between treatment arms in enrolled patients at Site j, S_1_A - S_1_B \\\\\n\\hline S_j_Min & Minimum number of enrolled patients in the two treatment arms at Site j , S_j_Min = min(S_j_A, S_j_B) \\\\\n\\hline S_j_PA & Probability for assigning the use next kits to treatment arm A in Site j, S_j_PA \\(=(\\) S_j_Min - S_j_A + MTI-C \\() /\\left(2^{*}\\right.\\) S_j_Min - S_j_A - S_j_B \\(+2^{*}\\) MTI-S \\()\\) \\\\\n\\hline O_A & Number of enrolled (ie, treated) patients in Treatment arm A \\\\\n\\hline O_B & Number of enrolled patients in Treatment arm B \\\\\n\\hline O_AB & Overall imbalance between treatment arms in enrolled patients, O_A - O_B, directionality required \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 4\nIntermediate Variables for the Next Allocation Probability}\n\\begin{tabular}{|l|l|}\n\\hline Variable & Definition \\\\\n\\hline S_j_A & Number of enrolled patients in Treatment Arm A at Site j \\\\\n\\hline S_j_B & Number of enrolled patients in Treatment Arm B at Site j \\\\\n\\hline S_j_AB & Imbalance between treatment arms in enrolled patients at Site j, S_1_A - S_1_B \\\\\n\\hline S_j_Min & Minimum number of enrolled patients in the two treatment arms at Site j , S_j_Min = min(S_j_A, S_j_B) \\\\\n\\hline S_j_PA & Probability for assigning the use next kits to treatment arm A in Site j, S_j_PA \\(=(\\) S_j_Min - S_j_A + MTI-C \\() /\\left(2^{*}\\right.\\) S_j_Min - S_j_A - S_j_B \\(+2^{*}\\) MTI-S \\()\\) \\\\\n\\hline O_A & Number of enrolled (ie, treated) patients in Treatment arm A \\\\\n\\hline O_B & Number of enrolled patients in Treatment arm B \\\\\n\\hline O_AB & Overall imbalance between treatment arms in enrolled patients, O_A - O_B, directionality required \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.4990818648575793,"confidence_rate":0.999275489564625},{"cnt":[[440,554],[560,554],[560,1119],[440,1119]],"region":{"top_left_x":439,"top_left_y":554,"width":121,"height":566},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"888f04f9694b418da1211eee42ce4319","type":"table_column","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[656,554],[1701,554],[1701,1119],[656,1119]],"region":{"top_left_x":656,"top_left_y":554,"width":1046,"height":566},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ce34e18ebdae41bfa69a2e3196019589","type":"table_column","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,568],[1748,568],[1748,606],[431,606]],"region":{"top_left_x":431,"top_left_y":567,"width":1317,"height":39},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9da9141e2c6a4046a20e72d321a3a51e","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,619],[1746,619],[1746,661],[431,661]],"region":{"top_left_x":431,"top_left_y":619,"width":1315,"height":42},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f323e9a8cb79448aa6908be97e9b3a74","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,667],[1746,667],[1746,712],[431,712]],"region":{"top_left_x":431,"top_left_y":667,"width":1315,"height":46},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e52b0d7fc50d4486b2f5ea6424518000","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,716],[1746,716],[1746,764],[431,764]],"region":{"top_left_x":431,"top_left_y":715,"width":1315,"height":49},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"12488d53cb51446788961c48a3fb7a2b","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,765],[1746,765],[1746,848],[431,848]],"region":{"top_left_x":431,"top_left_y":765,"width":1315,"height":83},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f0eeb8e19c614048be6d13a822355bf6","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,850],[1746,850],[1746,932],[431,932]],"region":{"top_left_x":431,"top_left_y":849,"width":1315,"height":84},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"777dc1f9732c4753b5d0181e77471520","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,934],[1746,934],[1746,977],[431,977]],"region":{"top_left_x":431,"top_left_y":933,"width":1315,"height":44},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e98cd580b77743c687abccfb8c5cce10","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,984],[1746,984],[1746,1028],[431,1028]],"region":{"top_left_x":431,"top_left_y":983,"width":1315,"height":46},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5d2bf4c15b8342bbbaba61951b8f34ae","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[431,1032],[1746,1032],[1746,1113],[431,1113]],"region":{"top_left_x":431,"top_left_y":1031,"width":1315,"height":82},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1cdde8b4402e4e88998a03aebd41ee40","type":"table_row","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"","text_display":""},{"cnt":[[441,571],[556,571],[556,600],[441,600]],"region":{"top_left_x":441,"top_left_y":571,"width":116,"height":30},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"14a1e14428874adda3897a938734c71a","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Variable","text_display":"Variable","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1136,571],[1263,571],[1263,602],[1136,602]],"region":{"top_left_x":1135,"top_left_y":571,"width":128,"height":32},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92862edfdbcd4ea498ee8334a67f518a","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Definition","text_display":"Definition","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[441,623],[529,623],[529,659],[441,659]],"region":{"top_left_x":441,"top_left_y":622,"width":88,"height":37},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3c9b8ba254e40268b63d1ddaa1832dd","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"S_j_A","text_display":"S_j_A","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[665,623],[1390,623],[1390,659],[665,659]],"region":{"top_left_x":664,"top_left_y":622,"width":727,"height":37},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d399d7b7128242d9914e496f24267f33","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Number of enrolled patients in Treatment Arm A at Site j","text_display":"Number of enrolled patients in Treatment Arm A at Site j","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[440,709],[441,671],[526,674],[525,711]],"region":{"top_left_x":440,"top_left_y":671,"width":87,"height":40},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c2b74a5317a4daca396fd06a0104ad3","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"S_j_B","text_display":"S_j_B","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[665,673],[1390,673],[1390,709],[665,709]],"region":{"top_left_x":664,"top_left_y":672,"width":727,"height":37},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e785ecf9d4d4660968371cb03817142","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Number of enrolled patients in Treatment Arm B at Site j","text_display":"Number of enrolled patients in Treatment Arm B at Site j","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[441,722],[546,722],[546,757],[441,757]],"region":{"top_left_x":441,"top_left_y":722,"width":106,"height":35},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ff783c896c7427f9ad24e163d3744c6","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"S_j_AB","text_display":"S_j_AB","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[665,721],[1694,721],[1694,757],[665,757]],"region":{"top_left_x":664,"top_left_y":720,"width":1031,"height":37},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cec7db164c5943fab7ce664ebc849c59","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Imbalance between treatment arms in enrolled patients at Site j, S_1_A - S_1_B","text_display":"Imbalance between treatment arms in enrolled patients at Site j, S_1_A - S_1_B","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[441,771],[553,771],[553,807],[441,807]],"region":{"top_left_x":441,"top_left_y":770,"width":113,"height":37},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84c7c8281e9b49e3b7a2ab0f2a7f77ef","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"S_j_Min","text_display":"S_j_Min","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[661,767],[1596,767],[1596,844],[661,844]],"region":{"top_left_x":661,"top_left_y":767,"width":936,"height":78},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d1fcba94ca64084a3a8f98d079c40d1","type":"complex_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","children_ids":["c6d7b1c7fbe54dcf89b54afa5f79243c","d6777f2621b546f4869b3fb3dd2e4e9e"],"text":"Minimum number of enrolled patients in the two treatment arms at Site j , S_j_Min = min(S_j_A, S_j_B)","text_display":"Minimum number of enrolled patients in the two treatment arms at Site j , S_j_Min = min(S_j_A, S_j_B)","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.4990818648575793,"confidence_rate":0.9887889340256614},{"cnt":[[665,771],[1593,771],[1593,807],[665,807]],"region":{"top_left_x":664,"top_left_y":770,"width":929,"height":37},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6d7b1c7fbe54dcf89b54afa5f79243c","type":"text","conversion_output":false,"parent_id":"2d1fcba94ca64084a3a8f98d079c40d1","text":"Minimum number of enrolled patients in the two treatment arms at Site j ,","text_display":"Minimum number of enrolled patients in the two treatment arms at Site j ,","confidence":0.9326171875,"confidence_rate":0.999169863026902},{"cnt":[[665,805],[1045,805],[1045,841],[665,841]],"region":{"top_left_x":664,"top_left_y":804,"width":381,"height":38},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6777f2621b546f4869b3fb3dd2e4e9e","type":"text","conversion_output":false,"parent_id":"2d1fcba94ca64084a3a8f98d079c40d1","text":"S_j_Min = min(S_j_A, S_j_B)","text_display":" S_j_Min = min(S_j_A, S_j_B)","confidence":0.4990818648575793,"confidence_rate":0.978515858244295},{"cnt":[[445,853],[546,853],[546,889],[445,889]],"region":{"top_left_x":444,"top_left_y":853,"width":103,"height":37},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20d142d90478468fbb6ea9490e5fb9ce","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"S_j_PA","text_display":"S_j_PA","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9965834617614746,"confidence_rate":0.9996889222190116},{"cnt":[[661,850],[1665,850],[1665,929],[661,929]],"region":{"top_left_x":661,"top_left_y":849,"width":1005,"height":80},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e2af99488f443dfad2e349bcf30acb5","type":"complex_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","children_ids":["973068af25844256875ddec7774fa356","6f5234d9744342c68f541aaf20a330fe"],"text":"Probability for assigning the use next kits to treatment arm A in Site j, S_j_PA \\(=(\\) S_j_Min - S_j_A + MTI-C \\() /\\left(2^{*}\\right.\\) S_j_Min - S_j_A - S_j_B \\(+2^{*}\\) MTI-S \\()\\)","text_display":"Probability for assigning the use next kits to treatment arm A in Site j, S_j_PA \\(=(\\) S_j_Min - S_j_A + MTI-C \\() /\\left(2^{*}\\right.\\) S_j_Min - S_j_A - S_j_B \\(+2^{*}\\) MTI-S \\()\\)","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.7387323601129882,"confidence_rate":0.9985406613477276},{"cnt":[[665,853],[1553,853],[1553,889],[665,889]],"region":{"top_left_x":664,"top_left_y":853,"width":890,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"973068af25844256875ddec7774fa356","type":"text","conversion_output":false,"parent_id":"8e2af99488f443dfad2e349bcf30acb5","text":"Probability for assigning the use next kits to treatment arm A in Site j,","text_display":"Probability for assigning the use next kits to treatment arm A in Site j,","confidence":0.9795806023757905,"confidence_rate":0.9997355381085647},{"cnt":[[665,887],[1662,887],[1662,927],[665,927]],"region":{"top_left_x":664,"top_left_y":887,"width":998,"height":40},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f5234d9744342c68f541aaf20a330fe","type":"text","conversion_output":false,"parent_id":"8e2af99488f443dfad2e349bcf30acb5","text":"S_j_PA \\(=(\\) S_j_Min - S_j_A + MTI-C \\() /\\left(2^{*}\\right.\\) S_j_Min - S_j_A - S_j_B \\(+2^{*}\\) MTI-S \\()\\)","text_display":" S_j_PA \\(=(\\) S_j_Min - S_j_A + MTI-C \\() /\\left(2^{*}\\right.\\) S_j_Min - S_j_A - S_j_B \\(+2^{*}\\) MTI-S \\()\\)","confidence":0.7387323601129882,"confidence_rate":0.9973472126950442},{"cnt":[[445,939],[508,939],[508,973],[445,973]],"region":{"top_left_x":444,"top_left_y":939,"width":65,"height":35},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72289997a9a3425baecd3b5b0b952a1b","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"O_A","text_display":"O_A","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[665,939],[1440,939],[1440,975],[665,975]],"region":{"top_left_x":664,"top_left_y":939,"width":776,"height":37},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0d0363e4d854eee8591edb71560edf9","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Number of enrolled (ie, treated) patients in Treatment arm A","text_display":"Number of enrolled (ie, treated) patients in Treatment arm A","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,987],[507,987],[507,1023],[445,1023]],"region":{"top_left_x":444,"top_left_y":987,"width":63,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3145bf080e7346d282835c885f9d0dde","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"O_B","text_display":"O_B","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[665,987],[1282,987],[1282,1023],[665,1023]],"region":{"top_left_x":664,"top_left_y":987,"width":618,"height":37},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4cce9fee125f419c91b9a9bba14c21c4","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"Number of enrolled patients in Treatment arm B","text_display":"Number of enrolled patients in Treatment arm B","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,1035],[526,1035],[526,1071],[445,1071]],"region":{"top_left_x":444,"top_left_y":1035,"width":82,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9721b0aed8a547e28ea155f8296d79ae","type":"simple_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","text":"O_AB","text_display":"O_AB","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[661,1035],[1483,1035],[1483,1109],[661,1109]],"region":{"top_left_x":661,"top_left_y":1035,"width":822,"height":75},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf4453a9c7104a1a806466fefc2c7da2","type":"complex_cell","conversion_output":false,"parent_id":"2432d35fc5d84c128c64483b77eeb6e8","children_ids":["0f649770b27341b38b381fac416db7c4","57be3bda3df943ffa33e54018379ca2c"],"text":"Overall imbalance between treatment arms in enrolled patients, O_A - O_B, directionality required","text_display":"Overall imbalance between treatment arms in enrolled patients, O_A - O_B, directionality required","cell_row":8,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[665,1037],[1481,1037],[1481,1071],[665,1071]],"region":{"top_left_x":664,"top_left_y":1036,"width":818,"height":36},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f649770b27341b38b381fac416db7c4","type":"text","conversion_output":false,"parent_id":"cf4453a9c7104a1a806466fefc2c7da2","text":"Overall imbalance between treatment arms in enrolled patients,","text_display":"Overall imbalance between treatment arms in enrolled patients,","confidence":1,"confidence_rate":1},{"cnt":[[665,1071],[1103,1071],[1103,1106],[665,1106]],"region":{"top_left_x":664,"top_left_y":1071,"width":440,"height":35},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57be3bda3df943ffa33e54018379ca2c","type":"text","conversion_output":false,"parent_id":"cf4453a9c7104a1a806466fefc2c7da2","text":"O_A - O_B, directionality required","text_display":" O_A - O_B, directionality required","confidence":1,"confidence_rate":1},{"cnt":[[718,1216],[1463,1216],[1463,1304],[718,1304]],"region":{"top_left_x":717,"top_left_y":1216,"width":747,"height":89},"line":40,"column":0,"font_size":31,"is_printed":true,"is_handwritten":false,"id":"c1ab0264fd784ababfba2d23f9115e3b","type":"figure_label","conversion_output":false,"children_ids":["c6f5e540eceb435a8162835a2a31429d","96a8755b47144caebc599ab6ef9c31e3"],"text":"","text_display":""},{"cnt":[[1023,1220],[1154,1220],[1154,1257],[1023,1257]],"region":{"top_left_x":1022,"top_left_y":1220,"width":132,"height":37},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6f5e540eceb435a8162835a2a31429d","type":"text","conversion_output":false,"parent_id":"c1ab0264fd784ababfba2d23f9115e3b","text":"Table 5","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[718,1268],[1459,1268],[1459,1300],[718,1300]],"region":{"top_left_x":717,"top_left_y":1267,"width":742,"height":33},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96a8755b47144caebc599ab6ef9c31e3","type":"text","conversion_output":false,"parent_id":"c1ab0264fd784ababfba2d23f9115e3b","text":"Decisions Based on Site and Overall Imbalance","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[432,1326],[1747,1326],[1747,1815],[432,1815]],"region":{"top_left_x":431,"top_left_y":1325,"width":1316,"height":491},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d9223f8127d4d53a0f0ad294620280e","type":"table","conversion_output":true,"children_ids":["2f9682c8fde24b668fe54d6d48628e3e","d9a233d42bd84a999109a6060c084da3","4c3f6d93ae094a26b4a0686733d99d48","f0a4a8cadfb6472bb9b4bd54c3cc5017","0fa552de87964b708e2956281c914278","babd0e3aade9448fad1ab74a6e64b56b","45567af99ff341c59667e9776ee45725","e58cdeee53ef4f8e98b502f58806b0a1","7f3a5061747c48179f5ba4cdb2272a77","aabcfcda3fb14d7692fb774695b2e266","c4969206bf614fae93e16b3bbe42cd54","0e90698ad16645518b672528286b4883","19d9c0234f164260948ec9efff03dd3a","26ac9a5dae4f4f92bbd664c0327acc1e","2b2ae884babe47f5b1bb7e9d18da8d4d","06c1c03c7661432f8e8a16d364981088","f4ad8b844e6b47ebbb56a5b7eced8ae2","0205e4147b7c430f890386fac978a478","3905c4044a4444439c43cf5f654b70ec","60cfa6332f2448d698240e4901831f23","81e4f63a83b74475a2cf56e7c804b874","9f284b35db1d4f019a92bac620355f16","fa5a6bef13a947c2b7115b325b893d3c","b54bee15cbfe4524ab426a697e6379dd","c50f7c6161bb4c00bf91a8a506a4a385","632e9b955b7c4b28b945707706f2ba25","b00bb32b195f4d8396ec7aaaeb4650b3","9f38b98e0a5b464b95f204ac155054d4","9d2c7f9be20746b5b18dce6861abd0a6","014bbaf9317e4d32a912f3aa5f4adf0c","1a90ac88b0014446a6cb5908b78b25ee","1992c2e7a4b94e76aebcafad3766f23f","25a3604c512a4593b9b9536619a354ac","8746c4acab0745bab99cf944e8449ca3","f8561b69662445dd89fa97198682b122","16bfe1deb23d4f9d9248b9ef1105c274"],"selected_labels":["c1ab0264fd784ababfba2d23f9115e3b"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline Step & Site Threshold Comparison & Type of Assignment & USE NEXT Kit Assignment \\\\\n\\hline 1 & If S_j_AB <= -MTI-S & Deterministic & Treatment Arm A. \\\\\n\\hline & If S_j_AB >=+ MTI-S & Deterministic & Treatment Arm B. \\\\\n\\hline & if -MTI-S < S_j_AB < + MTI-S & & Go to STEP 2 \\\\\n\\hline 2 & If S_j_PA \\(=0.5\\) & \\multicolumn{2}{|c|}{Check overall imbalance, O_AB} \\\\\n\\hline & If O_AB <= -MTI-O & Probabilistic & Treatment Arm A with probability P_BC \\\\\n\\hline & If O_AB >= + MTI-O & Probabilistic & Treatment Arm A with probability 1 P_BC \\\\\n\\hline & If S_j_PA ne 0.5 & & Treatment Arm A with probability S_j_PA \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5\nDecisions Based on Site and Overall Imbalance}\n\\begin{tabular}{|l|l|l|l|}\n\\hline Step & Site Threshold Comparison & Type of Assignment & USE NEXT Kit Assignment \\\\\n\\hline 1 & If S_j_AB <= -MTI-S & Deterministic & Treatment Arm A. \\\\\n\\hline & If S_j_AB >=+ MTI-S & Deterministic & Treatment Arm B. \\\\\n\\hline & if -MTI-S < S_j_AB < + MTI-S & & Go to STEP 2 \\\\\n\\hline 2 & If S_j_PA \\(=0.5\\) & \\multicolumn{2}{|c|}{Check overall imbalance, O_AB} \\\\\n\\hline & If O_AB <= -MTI-O & Probabilistic & Treatment Arm A with probability P_BC \\\\\n\\hline & If O_AB >= + MTI-O & Probabilistic & Treatment Arm A with probability 1 P_BC \\\\\n\\hline & If S_j_PA ne 0.5 & & Treatment Arm A with probability S_j_PA \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.69921875,"confidence_rate":0.998294385155979},{"cnt":[[437,1325],[515,1325],[515,1817],[437,1817]],"region":{"top_left_x":437,"top_left_y":1325,"width":79,"height":492},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f9682c8fde24b668fe54d6d48628e3e","type":"table_column","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[526,1325],[925,1325],[925,1817],[526,1817]],"region":{"top_left_x":526,"top_left_y":1325,"width":399,"height":492},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9a233d42bd84a999109a6060c084da3","type":"table_column","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[970,1325],[1152,1325],[1152,1817],[970,1817]],"region":{"top_left_x":970,"top_left_y":1325,"width":183,"height":492},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4c3f6d93ae094a26b4a0686733d99d48","type":"table_column","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[1182,1325],[1726,1325],[1726,1817],[1182,1817]],"region":{"top_left_x":1182,"top_left_y":1325,"width":544,"height":492},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0a4a8cadfb6472bb9b4bd54c3cc5017","type":"table_column","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1334],[1748,1334],[1748,1414],[431,1414]],"region":{"top_left_x":431,"top_left_y":1333,"width":1317,"height":81},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fa552de87964b708e2956281c914278","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1425],[1748,1425],[1748,1466],[431,1466]],"region":{"top_left_x":431,"top_left_y":1424,"width":1317,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"babd0e3aade9448fad1ab74a6e64b56b","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1470],[1748,1470],[1748,1518],[431,1518]],"region":{"top_left_x":431,"top_left_y":1470,"width":1317,"height":48},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45567af99ff341c59667e9776ee45725","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1522],[1748,1522],[1748,1565],[431,1565]],"region":{"top_left_x":431,"top_left_y":1522,"width":1317,"height":44},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e58cdeee53ef4f8e98b502f58806b0a1","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1620],[1748,1620],[1748,1663],[431,1663]],"region":{"top_left_x":431,"top_left_y":1619,"width":1317,"height":44},"line":52,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f3a5061747c48179f5ba4cdb2272a77","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1671],[1748,1671],[1748,1713],[431,1713]],"region":{"top_left_x":431,"top_left_y":1671,"width":1317,"height":42},"line":53,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aabcfcda3fb14d7692fb774695b2e266","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1719],[1748,1719],[1748,1760],[431,1760]],"region":{"top_left_x":431,"top_left_y":1719,"width":1317,"height":42},"line":54,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c4969206bf614fae93e16b3bbe42cd54","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[431,1771],[1748,1771],[1748,1812],[431,1812]],"region":{"top_left_x":431,"top_left_y":1771,"width":1317,"height":42},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0e90698ad16645518b672528286b4883","type":"table_row","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"","text_display":""},{"cnt":[[448,1377],[513,1377],[513,1412],[448,1412]],"region":{"top_left_x":448,"top_left_y":1376,"width":66,"height":36},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19d9c0234f164260948ec9efff03dd3a","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Step","text_display":"Step","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[565,1377],[918,1377],[918,1409],[565,1409]],"region":{"top_left_x":565,"top_left_y":1376,"width":354,"height":34},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26ac9a5dae4f4f92bbd664c0327acc1e","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Site Threshold Comparison","text_display":"Site Threshold Comparison","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[977,1342],[1146,1342],[1146,1414],[977,1414]],"region":{"top_left_x":976,"top_left_y":1342,"width":170,"height":72},"line":58,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b2ae884babe47f5b1bb7e9d18da8d4d","type":"complex_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","children_ids":["7e80a6ede29e422ba8deaafb76cb9b9e","91f299e0623c42f6a57560799263c5c7"],"text":"Type of Assignment","text_display":"Type of Assignment","cell_row":0,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1011,1342],[1113,1342],[1113,1375],[1011,1375]],"region":{"top_left_x":1011,"top_left_y":1342,"width":103,"height":33},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e80a6ede29e422ba8deaafb76cb9b9e","type":"text","conversion_output":false,"parent_id":"2b2ae884babe47f5b1bb7e9d18da8d4d","text":"Type of","text_display":"Type of","confidence":1,"confidence_rate":1},{"cnt":[[981,1377],[1139,1377],[1139,1409],[981,1409]],"region":{"top_left_x":981,"top_left_y":1376,"width":159,"height":34},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91f299e0623c42f6a57560799263c5c7","type":"text","conversion_output":false,"parent_id":"2b2ae884babe47f5b1bb7e9d18da8d4d","text":"Assignment","text_display":" Assignment","confidence":1,"confidence_rate":1},{"cnt":[[1280,1377],[1631,1377],[1631,1409],[1280,1409]],"region":{"top_left_x":1279,"top_left_y":1376,"width":352,"height":34},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06c1c03c7661432f8e8a16d364981088","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"USE NEXT Kit Assignment","text_display":"USE NEXT Kit Assignment","cell_row":0,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1429],[461,1429],[461,1459],[431,1459]],"region":{"top_left_x":431,"top_left_y":1428,"width":31,"height":32},"line":62,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f4ad8b844e6b47ebbb56a5b7eced8ae2","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"1","text_display":"1","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[535,1429],[801,1429],[801,1461],[535,1461]],"region":{"top_left_x":534,"top_left_y":1428,"width":268,"height":34},"line":63,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0205e4147b7c430f890386fac978a478","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"If S_j_AB <= -MTI-S","text_display":"If S_j_AB <= -MTI-S","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99951171875,"confidence_rate":0.9999796501863057},{"cnt":[[977,1429],[1148,1429],[1148,1457],[977,1457]],"region":{"top_left_x":976,"top_left_y":1428,"width":172,"height":30},"line":64,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3905c4044a4444439c43cf5f654b70ec","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Deterministic","text_display":"Deterministic","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1341,1429],[1570,1429],[1570,1457],[1341,1457]],"region":{"top_left_x":1340,"top_left_y":1428,"width":231,"height":30},"line":65,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"60cfa6332f2448d698240e4901831f23","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Treatment Arm A.","text_display":"Treatment Arm A.","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[535,1477],[810,1477],[810,1509],[535,1509]],"region":{"top_left_x":534,"top_left_y":1476,"width":276,"height":34},"line":66,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81e4f63a83b74475a2cf56e7c804b874","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"If S_j_AB >=+ MTI-S","text_display":"If S_j_AB >=+ MTI-S","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.8317829321959961,"confidence_rate":0.9923550486451126},{"cnt":[[977,1477],[1148,1477],[1148,1505],[977,1505]],"region":{"top_left_x":976,"top_left_y":1476,"width":172,"height":29},"line":67,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f284b35db1d4f019a92bac620355f16","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Deterministic","text_display":"Deterministic","cell_row":2,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1338,1477],[1570,1477],[1570,1505],[1338,1505]],"region":{"top_left_x":1338,"top_left_y":1476,"width":233,"height":29},"line":68,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fa5a6bef13a947c2b7115b325b893d3c","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Treatment Arm B.","text_display":"Treatment Arm B.","cell_row":2,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[533,1529],[918,1529],[918,1561],[533,1561]],"region":{"top_left_x":532,"top_left_y":1528,"width":387,"height":34},"line":69,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b54bee15cbfe4524ab426a697e6379dd","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"if -MTI-S < S_j_AB < + MTI-S","text_display":"if -MTI-S < S_j_AB < + MTI-S","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9892890325281769,"confidence_rate":0.9996737276987686},{"cnt":[[1258,1529],[1442,1529],[1442,1557],[1258,1557]],"region":{"top_left_x":1258,"top_left_y":1528,"width":185,"height":29},"line":70,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c50f7c6161bb4c00bf91a8a506a4a385","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Go to STEP 2","text_display":"Go to STEP 2","cell_row":3,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[431,1628],[461,1628],[461,1654],[431,1654]],"region":{"top_left_x":431,"top_left_y":1628,"width":31,"height":27},"line":71,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"632e9b955b7c4b28b945707706f2ba25","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"2","text_display":"2","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[535,1624],[728,1624],[728,1656],[535,1656]],"region":{"top_left_x":534,"top_left_y":1623,"width":194,"height":34},"line":72,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b00bb32b195f4d8396ec7aaaeb4650b3","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"If S_j_PA \\(=0.5\\)","text_display":"If S_j_PA \\(=0.5\\)","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.69921875,"confidence_rate":0.9803189380660737},{"cnt":[[975,1622],[1724,1622],[1724,1661],[975,1661]],"region":{"top_left_x":974,"top_left_y":1621,"width":750,"height":40},"line":73,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f38b98e0a5b464b95f204ac155054d4","type":"table_spanning_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","children_ids":["92c958bd4961428eb084a180f3bee2ab"],"text":"","text_display":"Check overall imbalance, O_AB","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":2},{"cnt":[[1143,1624],[1555,1624],[1555,1656],[1143,1656]],"region":{"top_left_x":1143,"top_left_y":1623,"width":412,"height":34},"line":74,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92c958bd4961428eb084a180f3bee2ab","type":"simple_cell","conversion_output":false,"parent_id":"9f38b98e0a5b464b95f204ac155054d4","text":"Check overall imbalance, O_AB","text_display":"Check overall imbalance, O_AB","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":2,"confidence":0.9990234375,"confidence_rate":0.9999712639526579},{"cnt":[[565,1674],[823,1674],[823,1708],[565,1708]],"region":{"top_left_x":565,"top_left_y":1673,"width":258,"height":36},"line":75,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d2c7f9be20746b5b18dce6861abd0a6","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"If O_AB <= -MTI-O","text_display":"If O_AB <= -MTI-O","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.9150390625,"confidence_rate":0.9959722910943172},{"cnt":[[981,1676],[1141,1676],[1141,1704],[981,1704]],"region":{"top_left_x":981,"top_left_y":1675,"width":161,"height":29},"line":76,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"014bbaf9317e4d32a912f3aa5f4adf0c","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Probabilistic","text_display":"Probabilistic","cell_row":5,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1202,1676],[1706,1676],[1706,1708],[1202,1708]],"region":{"top_left_x":1201,"top_left_y":1675,"width":506,"height":34},"line":77,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a90ac88b0014446a6cb5908b78b25ee","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Treatment Arm A with probability P_BC","text_display":"Treatment Arm A with probability P_BC","cell_row":5,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[565,1723],[823,1723],[823,1758],[565,1758]],"region":{"top_left_x":565,"top_left_y":1723,"width":258,"height":36},"line":78,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1992c2e7a4b94e76aebcafad3766f23f","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"If O_AB >= + MTI-O","text_display":"If O_AB >= + MTI-O","cell_row":6,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.8531570434570312,"confidence_rate":0.9931189297655967},{"cnt":[[981,1723],[1143,1723],[1143,1752],[981,1752]],"region":{"top_left_x":981,"top_left_y":1723,"width":163,"height":29},"line":79,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25a3604c512a4593b9b9536619a354ac","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Probabilistic","text_display":"Probabilistic","cell_row":6,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1189,1723],[1719,1723],[1719,1760],[1189,1760]],"region":{"top_left_x":1188,"top_left_y":1723,"width":532,"height":38},"line":80,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8746c4acab0745bab99cf944e8449ca3","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Treatment Arm A with probability 1 P_BC","text_display":"Treatment Arm A with probability 1 P_BC","cell_row":6,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":0.9990234375,"confidence_rate":0.9999792121384572},{"cnt":[[531,1771],[745,1771],[745,1808],[531,1808]],"region":{"top_left_x":530,"top_left_y":1771,"width":215,"height":37},"line":81,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8561b69662445dd89fa97198682b122","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"If S_j_PA ne 0.5","text_display":"If S_j_PA ne 0.5","cell_row":7,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.99462890625,"confidence_rate":0.9997307577555706},{"cnt":[[1189,1771],[1719,1771],[1719,1808],[1189,1808]],"region":{"top_left_x":1188,"top_left_y":1771,"width":532,"height":37},"line":82,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"16bfe1deb23d4f9d9248b9ef1105c274","type":"simple_cell","conversion_output":false,"parent_id":"5d9223f8127d4d53a0f0ad294620280e","text":"Treatment Arm A with probability S_j_PA","text_display":"Treatment Arm A with probability S_j_PA","cell_row":7,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":0.994140625,"confidence_rate":0.9998664496348035},{"cnt":[[443,1822],[1729,1822],[1729,1858],[443,1858]],"region":{"top_left_x":442,"top_left_y":1821,"width":1288,"height":38},"line":83,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"acec10bc138d4cab90c7f5dd0b6c79e5","type":"text","conversion_output":true,"text":"Note: MTI-S is the site threshold level (ie, x). MTI-O is the overall threshold level (ie, y). P_BC is the","text_display":"\n\nNote: MTI-S is the site threshold level (ie, x). MTI-O is the overall threshold level (ie, y). P_BC is the","confidence":0.986328125,"confidence_rate":0.9998759879084762},{"cnt":[[443,1856],[866,1856],[866,1893],[443,1893]],"region":{"top_left_x":442,"top_left_y":1856,"width":424,"height":37},"line":84,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d632bfe8007c4fe0a5eb94e3ca2b5c43","type":"text","conversion_output":true,"text":"biased coin probability (ie, 0.75 ).","text_display":" biased coin probability (ie, 0.75 ).","confidence":0.9970703125,"confidence_rate":0.9999333206905552},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":85,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c466376bf20b424498b6921edb06c462","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[599,2368],[599,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":167,"height":33},"line":86,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b27752a5f84e6c9a763d7f5af46b88","type":"page_info","conversion_output":false,"text":"44/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":87,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0793ae9271a8405bbe912d98fa650429","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":88,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f6614df3811f4817ab07404ec68f6f95","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922086966757888,"confidence_rate":0.9998796716383385},{"cnt":[[372,2608],[694,2608],[694,2643],[372,2643]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":35},"line":89,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ae656c9fd1c2462d9ac3ff8dd8cc341a","type":"page_info","conversion_output":false,"text":"805/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-46","page":46,"lines":[{"cnt":[[1061,438],[1691,438],[1691,492],[1061,492]],"region":{"top_left_x":1061,"top_left_y":438,"width":630,"height":54},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c6acc0a073fa4961947e565a0c6b11e0","type":"figure_label","conversion_output":false,"text":"Figure 2 Study Randomization Schema","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[640,526],[2123,526],[2123,604],[640,604]],"region":{"top_left_x":640,"top_left_y":526,"width":1483,"height":78},"line":2,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"967b446793d044d1a28942a2cc69718e","type":"text","conversion_output":true,"text":"First patient at a site\nallocated according to: Subsequent patients allocated according to: block urn within sites and biased coin for overall balance","text_display":"\nFirst patient at a site\nallocated according to: Subsequent patients allocated according to: block urn within sites and biased coin for overall balance","confidence":0.9252328872680664,"confidence_rate":0.9995402843812727},{"cnt":[[632,619],[900,619],[900,655],[632,655]],"region":{"top_left_x":631,"top_left_y":618,"width":270,"height":38},"line":3,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"64b282151a854c789106c483beb8dd01","type":"text","conversion_output":true,"text":"Random Permutted Block","text_display":"\n\nRandom Permutted Block","confidence":1,"confidence_rate":1},{"cnt":[[664,649],[866,649],[866,681],[664,681]],"region":{"top_left_x":663,"top_left_y":648,"width":203,"height":34},"line":4,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"ad38cdb0cdba4e4380e2bf4d634c934c","type":"text","conversion_output":true,"text":"with Block Size of \\(n\\)","text_display":" with Block Size of \\(n\\)","confidence":1,"confidence_rate":1},{"cnt":[[1315,632],[1927,632],[1927,670],[1315,670]],"region":{"top_left_x":1314,"top_left_y":631,"width":614,"height":40},"line":5,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"aa3703e961b443d2970faa23085eeda3","type":"text","conversion_output":true,"text":"Block Um Within Sites and Biased Coin for Overall Imbalance","text_display":"\n\nBlock Um Within Sites and Biased Coin for Overall Imbalance","confidence":0.9677734375,"confidence_rate":0.999488298600254},{"cnt":[[606,683],[2140,683],[2140,1575],[606,1575]],"region":{"top_left_x":605,"top_left_y":683,"width":1535,"height":892},"line":6,"column":0,"font_size":18,"is_printed":true,"is_handwritten":false,"id":"f6641d195d394a669cc665af7c7084dd","type":"diagram","conversion_output":true,"selected_labels":["c6acc0a073fa4961947e565a0c6b11e0"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 2 Study Randomization Schema}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-46.jpg?height=892&width=1535&top_left_y=683&top_left_x=605}\n\\end{figure}"},{"cnt":[[432,1792],[1205,1792],[1205,1835],[432,1835]],"region":{"top_left_x":431,"top_left_y":1791,"width":775,"height":44},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20a886f6eb96417fbdb2c102acccab07","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[432,1830],[608,1830],[608,1867],[432,1867]],"region":{"top_left_x":431,"top_left_y":1830,"width":178,"height":37},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5eae3f613ca34375b180b21676b24cab","type":"text","conversion_output":true,"text":"45/ML29093","text_display":"\n45/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,1830],[1188,1830],[1188,1867],[1044,1867]],"region":{"top_left_x":1044,"top_left_y":1830,"width":145,"height":37},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3816cde97594f7a9765727662b59e23","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,1946],[1420,1946],[1420,1992],[370,1992]],"region":{"top_left_x":369,"top_left_y":1946,"width":1052,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fe5bee4210542dd91fd1e33a239b929","type":"text","conversion_output":true,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"\n\nAbbreviated Clinical Study Report: Alteplase-Genentech, Inc.","confidence":0.9946362947812304,"confidence_rate":0.9999172627839867},{"cnt":[[370,1983],[696,1983],[696,2022],[370,2022]],"region":{"top_left_x":369,"top_left_y":1983,"width":328,"height":39},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3588d2a84ce44ccbb2d8b077bb7f16e9","type":"text","conversion_output":true,"text":"806/aCSR ML29093","text_display":"\n806/aCSR ML29093","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-47","page":47,"lines":[{"cnt":[[791,440],[1388,440],[1388,531],[791,531]],"region":{"top_left_x":790,"top_left_y":440,"width":598,"height":91},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7265bd46f433459780b224632c7cf223","type":"section_header","conversion_output":false,"children_ids":["3065f561b442462c9f252127cb417987","1dc11f0d629a4fa9ab627c71d0a24852"],"text":"","text_display":""},{"cnt":[[988,443],[1188,443],[1188,483],[988,483]],"region":{"top_left_x":988,"top_left_y":442,"width":201,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3065f561b442462c9f252127cb417987","type":"text","conversion_output":true,"parent_id":"7265bd46f433459780b224632c7cf223","text":"Appendix D","text_display":"\n\n\\section*{Appendix D","confidence":1,"confidence_rate":1},{"cnt":[[795,486],[1386,486],[1386,526],[795,526]],"region":{"top_left_x":794,"top_left_y":485,"width":592,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dc11f0d629a4fa9ab627c71d0a24852","type":"text","conversion_output":true,"parent_id":"7265bd46f433459780b224632c7cf223","text":"Statistical Methods Requiring Input","text_display":" \\\\ Statistical Methods Requiring Input}","confidence":1,"confidence_rate":1},{"cnt":[[430,589],[1470,589],[1470,638],[430,638]],"region":{"top_left_x":429,"top_left_y":588,"width":1041,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06d9569a80684167aacaa5f15f132a2b","type":"section_header","conversion_output":false,"children_ids":["07a6e4cfd2cf4edbbcd43b6731ecfb9b"],"text":"","text_display":""},{"cnt":[[434,593],[1465,593],[1465,634],[434,634]],"region":{"top_left_x":433,"top_left_y":592,"width":1033,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07a6e4cfd2cf4edbbcd43b6731ecfb9b","type":"text","conversion_output":true,"parent_id":"06d9569a80684167aacaa5f15f132a2b","text":"Handling of incomplete start and stop dates of adverse events","text_display":"\n\n\\section*{Handling of incomplete start and stop dates of adverse events}","confidence":1,"confidence_rate":1},{"cnt":[[434,683],[1708,683],[1708,728],[434,728]],"region":{"top_left_x":433,"top_left_y":683,"width":1276,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c0699aa9982423294b025def3dbc835","type":"text","conversion_output":true,"text":"A missing day in a start date will be imputed with the first day of the month, but not","text_display":"\n\nA missing day in a start date will be imputed with the first day of the month, but not","confidence":1,"confidence_rate":1},{"cnt":[[434,735],[1742,735],[1742,780],[434,780]],"region":{"top_left_x":433,"top_left_y":734,"width":1310,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f8b6a7858c544afdbffe6f55a2d7f944","type":"text","conversion_output":true,"text":"earlier than the randomization date. A missing day in a stop date will be imputed with","text_display":" earlier than the randomization date. A missing day in a stop date will be imputed with","confidence":1,"confidence_rate":1},{"cnt":[[434,786],[831,786],[831,831],[434,831]],"region":{"top_left_x":433,"top_left_y":786,"width":399,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7474ea7ef1f4a82893e8f5a947728fa","type":"text","conversion_output":true,"text":"the last day of the month.","text_display":" the last day of the month.","confidence":1,"confidence_rate":1},{"cnt":[[434,881],[1566,881],[1566,926],[434,926]],"region":{"top_left_x":433,"top_left_y":880,"width":1134,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ec0d4c648d65484289fac8cb2f3b9a41","type":"text","conversion_output":true,"text":"A missing month/year in a start date will be imputed by the month/year of","text_display":"\n\nA missing month/year in a start date will be imputed by the month/year of","confidence":1,"confidence_rate":1},{"cnt":[[434,932],[1699,932],[1699,978],[434,978]],"region":{"top_left_x":433,"top_left_y":932,"width":1267,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7ed451fd844a4087b0be169fa69c85b8","type":"text","conversion_output":true,"text":"randomization. A missing month in a stop date will be imputed by the month of the","text_display":" randomization. A missing month in a stop date will be imputed by the month of the","confidence":1,"confidence_rate":1},{"cnt":[[434,984],[1691,984],[1691,1029],[434,1029]],"region":{"top_left_x":433,"top_left_y":983,"width":1258,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"57f3551c1b34472e98597c58e3729578","type":"text","conversion_output":true,"text":"last contact. A completely missing stop date will be treated as an ongoing AE and","text_display":" last contact. A completely missing stop date will be treated as an ongoing AE and","confidence":1,"confidence_rate":1},{"cnt":[[434,1036],[737,1036],[737,1081],[434,1081]],"region":{"top_left_x":433,"top_left_y":1035,"width":304,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8292b39a55ab4995967fd852b5ad2a89","type":"text","conversion_output":true,"text":"will not be imputed.","text_display":" will not be imputed.","confidence":1,"confidence_rate":1},{"cnt":[[432,1126],[1068,1126],[1068,1171],[432,1171]],"region":{"top_left_x":431,"top_left_y":1125,"width":637,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"af09abee0f3d4ca9b8efd4a69419cc6f","type":"section_header","conversion_output":false,"children_ids":["ee14edd9cfdc4cfba7974795027c59ea"],"text":"","text_display":""},{"cnt":[[434,1130],[1063,1130],[1063,1167],[434,1167]],"region":{"top_left_x":433,"top_left_y":1130,"width":631,"height":37},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee14edd9cfdc4cfba7974795027c59ea","type":"text","conversion_output":true,"parent_id":"af09abee0f3d4ca9b8efd4a69419cc6f","text":"Determination of ICH and sICH events","text_display":"\n\n\\section*{Determination of ICH and sICH events}","confidence":1,"confidence_rate":1},{"cnt":[[434,1222],[1699,1222],[1699,1265],[434,1265]],"region":{"top_left_x":433,"top_left_y":1222,"width":1267,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"03956797b37c47c989bc31c2760f971b","type":"text","conversion_output":true,"text":"For ICH and sICH events, the following rules will be used to determine their timing","text_display":"\n\nFor ICH and sICH events, the following rules will be used to determine their timing","confidence":1,"confidence_rate":1},{"cnt":[[434,1272],[746,1272],[746,1313],[434,1313]],"region":{"top_left_x":433,"top_left_y":1271,"width":313,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3acb64f5f7404e208aa622322f80d949","type":"text","conversion_output":true,"text":"relative to 36 hours:","text_display":" relative to 36 hours:","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[486,1366],[1669,1366],[1669,1412],[486,1412]],"region":{"top_left_x":485,"top_left_y":1366,"width":1185,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59ea5d5f859d4167b8e5456247707ca6","type":"text","conversion_output":true,"text":"- For ICH determination by scan reading (local or central), take the earliest","text_display":"\n- For ICH determination by scan reading (local or central), take the earliest","confidence":1,"confidence_rate":1},{"cnt":[[537,1418],[1687,1418],[1687,1463],[537,1463]],"region":{"top_left_x":537,"top_left_y":1417,"width":1150,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"be19a9a4d11843458780412f1dfbabc1","type":"text","conversion_output":true,"text":"post-baseline scan with bleeding identified. Use the evaluation time of that","text_display":" post-baseline scan with bleeding identified. Use the evaluation time of that","confidence":1,"confidence_rate":1},{"cnt":[[537,1470],[995,1470],[995,1515],[537,1515]],"region":{"top_left_x":537,"top_left_y":1469,"width":458,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"291f64d59d8047acb0c24379e0d9ea94","type":"text","conversion_output":true,"text":"scan to compare to 36 hours.","text_display":" scan to compare to 36 hours.","confidence":1,"confidence_rate":1},{"cnt":[[486,1564],[1532,1564],[1532,1609],[486,1609]],"region":{"top_left_x":485,"top_left_y":1564,"width":1047,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a5e32a5d5044c0cabd4180699d328e3","type":"text","conversion_output":true,"text":"- For ICH determination by AE reporting, take the start date of the","text_display":"\n- For ICH determination by AE reporting, take the start date of the","confidence":1,"confidence_rate":1},{"cnt":[[537,1616],[1687,1616],[1687,1661],[537,1661]],"region":{"top_left_x":537,"top_left_y":1615,"width":1150,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"333bd62e375c4f329fa139bd85c3feb7","type":"text","conversion_output":true,"text":"corresponding AE. Then find all scans with the same date of local reading,","text_display":" corresponding AE. Then find all scans with the same date of local reading,","confidence":0.99853515625,"confidence_rate":0.9999814442521284},{"cnt":[[537,1667],[1601,1667],[1601,1712],[537,1712]],"region":{"top_left_x":537,"top_left_y":1667,"width":1064,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3965c16704e4080b187d9a193869ed2","type":"text","conversion_output":true,"text":"where bleeding is identified. Take the earliest such scan and use the","text_display":" where bleeding is identified. Take the earliest such scan and use the","confidence":1,"confidence_rate":1},{"cnt":[[537,1719],[1712,1719],[1712,1764],[537,1764]],"region":{"top_left_x":537,"top_left_y":1718,"width":1176,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"150a817d52084b128c0ab841ceb0445d","type":"text","conversion_output":true,"text":"evaluation time of that scan to compare to 36 hours. If no scan is found, use","text_display":" evaluation time of that scan to compare to 36 hours. If no scan is found, use","confidence":1,"confidence_rate":1},{"cnt":[[537,1770],[1384,1770],[1384,1815],[537,1815]],"region":{"top_left_x":537,"top_left_y":1770,"width":847,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"38fbaf1f239c4bdc94738ee9118703ab","type":"text","conversion_output":true,"text":"12:00 am on the AE start date to compare to 36 hours.","text_display":" 12:00 am on the AE start date to compare to 36 hours.","confidence":1,"confidence_rate":1},{"cnt":[[434,1856],[1721,1856],[1721,1901],[434,1901]],"region":{"top_left_x":433,"top_left_y":1856,"width":1288,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2271d7e208914debab3d0df20aaee988","type":"text","conversion_output":true,"text":"When there are multiple scans associated with a PH2 bleed in a subject, the first of","text_display":"\n\nWhen there are multiple scans associated with a PH2 bleed in a subject, the first of","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[434,1899],[1493,1899],[1493,1944],[434,1944]],"region":{"top_left_x":433,"top_left_y":1899,"width":1061,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f3cc11fe50564647a7100cbf3d2424aa","type":"text","conversion_output":true,"text":"these scans will be used to select pre- and post-scan NIHSS scores.","text_display":" these scans will be used to select pre- and post-scan NIHSS scores.","confidence":1,"confidence_rate":1},{"cnt":[[430,2032],[1192,2032],[1192,2082],[430,2082]],"region":{"top_left_x":429,"top_left_y":2032,"width":764,"height":50},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40a2e460a0394caf82de99003aa1125d","type":"section_header","conversion_output":false,"children_ids":["68062e4674354becaf8882c8118e1b27"],"text":"","text_display":""},{"cnt":[[434,2037],[1188,2037],[1188,2078],[434,2078]],"region":{"top_left_x":433,"top_left_y":2036,"width":756,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"68062e4674354becaf8882c8118e1b27","type":"text","conversion_output":true,"parent_id":"40a2e460a0394caf82de99003aa1125d","text":"Logistic regression with correlated measures","text_display":"\n\n\\section*{Logistic regression with correlated measures}","confidence":1,"confidence_rate":1},{"cnt":[[434,2127],[1682,2127],[1682,2172],[434,2172]],"region":{"top_left_x":433,"top_left_y":2126,"width":1250,"height":47},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f1b72dbc413448db8f50070e6b73d5a","type":"text","conversion_output":true,"text":"This model will be used to estimate the odds ratio describing the global favorable","text_display":"\n\nThis model will be used to estimate the odds ratio describing the global favorable","confidence":1,"confidence_rate":1},{"cnt":[[434,2179],[1646,2179],[1646,2224],[434,2224]],"region":{"top_left_x":433,"top_left_y":2178,"width":1213,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83371b671bb6416ebae1173e625fbafe","type":"text","conversion_output":true,"text":"outcome, and to estimate the odds ratio of achieving mRS 0-1 at Day 90 in the","text_display":" outcome, and to estimate the odds ratio of achieving mRS 0-1 at Day 90 in the","confidence":0.7599221030250192,"confidence_rate":0.9969876304168552},{"cnt":[[434,2230],[913,2230],[913,2275],[434,2275]],"region":{"top_left_x":433,"top_left_y":2230,"width":481,"height":46},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b15857633201402486e83581552b1fb0","type":"text","conversion_output":true,"text":"context of repeated measures.","text_display":" context of repeated measures.","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1201,2368],[1201,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":38},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"171dc875f9e847009bd2fa0db4002f6f","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[599,2402],[599,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2401,"width":167,"height":34},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0aa48482e6bf4d07a71ef3c651b36e8d","type":"page_info","conversion_output":false,"text":"46/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":34},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e0981f7df6548f6b8e5f3e7afa34954","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eb8dd5787a8f4c12bcc029aff010f146","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9946377224997605,"confidence_rate":0.999917284865493},{"cnt":[[372,2608],[694,2608],[694,2645],[372,2645]],"region":{"top_left_x":371,"top_left_y":2608,"width":323,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2d44e910a1f94024b0562850558b6e62","type":"page_info","conversion_output":false,"text":"807/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-48","page":48,"lines":[{"cnt":[[434,447],[956,447],[956,492],[434,492]],"region":{"top_left_x":433,"top_left_y":446,"width":524,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c72720bba6b74ebf94c26e9ce19e7de0","type":"text","conversion_output":true,"text":"The model is specified as follows:","text_display":"\n\nThe model is specified as follows:","confidence":0.9912109375,"confidence_rate":0.9997736688443623},{"cnt":[[434,535],[1510,535],[1510,578],[434,578]],"region":{"top_left_x":433,"top_left_y":534,"width":1078,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1bd8916fd44148818381b72bac4b899a","type":"text","conversion_output":true,"text":"- Let \\(Y _{ ik }\\), be the correlated binary outcomes ( \\(1=\\) favorable outcome,","text_display":"\n- Let \\(Y _{ ik }\\), be the correlated binary outcomes ( \\(1=\\) favorable outcome,","confidence":0.3673703670501709,"confidence_rate":0.9892901847400909},{"cnt":[[486,576],[1729,576],[1729,621],[486,621]],"region":{"top_left_x":485,"top_left_y":575,"width":1245,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81ee8d761dae4c599bd8438da8ea9820","type":"text","conversion_output":true,"text":"\\(0=\\) unfavorable outcome) for patient i , and let \\(E \\left( Y _{ ik }\\right)=\\mu_{ ik }\\) be the marginal means","text_display":" \\(0=\\) unfavorable outcome) for patient i , and let \\(E \\left( Y _{ ik }\\right)=\\mu_{ ik }\\) be the marginal means","confidence":0.9975602623308077,"confidence_rate":0.9999794731629581},{"cnt":[[486,621],[1588,621],[1588,664],[486,664]],"region":{"top_left_x":485,"top_left_y":620,"width":1103,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88f818d9620840b797b9cb7d84fa453a","type":"text","conversion_output":true,"text":"of the outcomes conditional on the patient-specific covariates, including","text_display":" of the outcomes conditional on the patient-specific covariates, including","confidence":1,"confidence_rate":1},{"cnt":[[486,666],[649,666],[649,703],[486,703]],"region":{"top_left_x":485,"top_left_y":666,"width":164,"height":37},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4fa00c9199ed438bab9deef1c4c67849","type":"text","conversion_output":true,"text":"treatment.","text_display":" treatment.","confidence":1,"confidence_rate":1},{"cnt":[[486,726],[1613,726],[1613,769],[486,769]],"region":{"top_left_x":485,"top_left_y":726,"width":1129,"height":44},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b9b215820794ccba2f6a1c80d4d7088","type":"text","conversion_output":true,"text":"For the analysis of the global favorable outcome, \\(k =1, \\ldots, 4\\) will index the 4","text_display":"\n\nFor the analysis of the global favorable outcome, \\(k =1, \\ldots, 4\\) will index the 4","confidence":0.998535871389322,"confidence_rate":0.9999825572771935},{"cnt":[[486,769],[1128,769],[1128,814],[486,814]],"region":{"top_left_x":485,"top_left_y":769,"width":643,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b26ed080972145a4be0fa09f22bd4cff","type":"text","conversion_output":true,"text":"dimensions (mRS, NIHSS, BI, and GOS).","text_display":" dimensions (mRS, NIHSS, BI, and GOS).","confidence":1,"confidence_rate":1},{"cnt":[[486,834],[1687,834],[1687,879],[486,879]],"region":{"top_left_x":485,"top_left_y":833,"width":1202,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e036820e9f214781a7ac50ffb2609084","type":"text","conversion_output":true,"text":"For the analysis of \\(mRS 0-1 k =1,2\\) will index the repeated evaluations of mRS","text_display":"\n\nFor the analysis of \\(mRS 0-1 k =1,2\\) will index the repeated evaluations of mRS","confidence":0.9609375,"confidence_rate":0.9995573656742993},{"cnt":[[486,877],[823,877],[823,922],[486,922]],"region":{"top_left_x":485,"top_left_y":876,"width":338,"height":46},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b73b2044ba104f07b7dc98b9b613206a","type":"text","conversion_output":true,"text":"(Day 30 and Day 90).","text_display":" (Day 30 and Day 90).","confidence":1,"confidence_rate":1},{"cnt":[[434,941],[1687,941],[1687,986],[434,986]],"region":{"top_left_x":433,"top_left_y":941,"width":1254,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc92ff1fd3774a8d85a42d64b84c12bc","type":"text","conversion_output":true,"text":"- The linear predictor will include an outcome-specific intercept \\(\\alpha_{k}\\), treatment \\(T_{i}\\),","text_display":"\n- The linear predictor will include an outcome-specific intercept \\(\\alpha_{k}\\), treatment \\(T_{i}\\),","confidence":0.9443228440359235,"confidence_rate":0.9994793430843039},{"cnt":[[486,984],[1661,984],[1661,1029],[486,1029]],"region":{"top_left_x":485,"top_left_y":983,"width":1176,"height":47},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"56191089afcf47599db65919d22aa08f","type":"text","conversion_output":true,"text":"and the explanatory variables \\(X _{ i }\\). The link function transforming the marginal","text_display":" and the explanatory variables \\(X _{ i }\\). The link function transforming the marginal","confidence":0.99853515625,"confidence_rate":0.9999851928603086},{"cnt":[[486,1027],[1510,1027],[1510,1072],[486,1072]],"region":{"top_left_x":485,"top_left_y":1026,"width":1026,"height":47},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"249f06be041e48b387cea76db3f7c528","type":"text","conversion_output":true,"text":"mean outcome \\(\\mu_{ ik }\\) into the linear predictor will be the logit function:","text_display":" mean outcome \\(\\mu_{ ik }\\) into the linear predictor will be the logit function:","confidence":0.99951171875,"confidence_rate":0.999994450009741},{"cnt":[[889,1091],[1287,1091],[1287,1147],[889,1147]],"region":{"top_left_x":889,"top_left_y":1091,"width":398,"height":57},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92a8b6087a04471a9350fefd49914674","type":"math","conversion_output":true,"text":"\\[\n\\operatorname{logit}\\left(\\mu_{i k}\\right)=\\alpha_{k}+\\beta T_{i}+\\gamma_{k} X_{i}\n\\]","text_display":"\n\\[\n\\operatorname{logit}\\left(\\mu_{i k}\\right)=\\alpha_{k}+\\beta T_{i}+\\gamma_{k} X_{i}\n\\]","confidence":1,"confidence_rate":1},{"cnt":[[486,1182],[1734,1182],[1734,1229],[486,1229]],"region":{"top_left_x":485,"top_left_y":1181,"width":1249,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a7863db6fd546909c770fd2c9baf531","type":"text","conversion_output":true,"text":"Importantly, it will be assumed that all outcomes share the same treatment effect","text_display":"\n\nImportantly, it will be assumed that all outcomes share the same treatment effect","confidence":1,"confidence_rate":1},{"cnt":[[483,1227],[524,1227],[524,1278],[483,1278]],"region":{"top_left_x":483,"top_left_y":1226,"width":42,"height":53},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"849a0ebbb3f147a8a9617f414ca57712","type":"text","conversion_output":true,"text":"\\(\\beta\\).","text_display":" \\(\\beta\\).","confidence":1,"confidence_rate":1},{"cnt":[[434,1289],[1738,1289],[1738,1334],[434,1334]],"region":{"top_left_x":433,"top_left_y":1289,"width":1306,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11e71f87001140ad8bbc33c5a13542fb","type":"text","conversion_output":true,"text":"- The variance function of \\(Y _{ ik }\\) will be determined by the binary distribution variance:","text_display":"\n- The variance function of \\(Y _{ ik }\\) will be determined by the binary distribution variance:","confidence":0.7479262351989746,"confidence_rate":0.99728918631177},{"cnt":[[928,1358],[1248,1358],[1248,1412],[928,1412]],"region":{"top_left_x":928,"top_left_y":1357,"width":321,"height":55},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70a641b511454420bfc094c6b8d2ca62","type":"math","conversion_output":true,"text":"\\[\n\\operatorname{Var}\\left(Y_{i k}\\right)=\\mu_{i k}\\left(1-\\mu_{i k}\\right)\n\\]","text_display":"\n\\[\n\\operatorname{Var}\\left(Y_{i k}\\right)=\\mu_{i k}\\left(1-\\mu_{i k}\\right)\n\\]","confidence":0.9951229095458984,"confidence_rate":0.9998863082710552},{"cnt":[[434,1448],[1721,1448],[1721,1491],[434,1491]],"region":{"top_left_x":433,"top_left_y":1448,"width":1288,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"408ecc6e8cdc4a1989195ed29d2a8abc","type":"text","conversion_output":true,"text":"- The working correlation matrix structure for the outcomes from the same patient","text_display":"\n- The working correlation matrix structure for the outcomes from the same patient","confidence":1,"confidence_rate":1},{"cnt":[[486,1491],[1038,1491],[1038,1532],[486,1532]],"region":{"top_left_x":485,"top_left_y":1491,"width":553,"height":41},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36ee248e1fb043c0afbc93211b0c591a","type":"text","conversion_output":true,"text":"will be assumed to be unstructured:","text_display":" will be assumed to be unstructured:","confidence":1,"confidence_rate":1},{"cnt":[[889,1555],[1287,1555],[1287,1609],[889,1609]],"region":{"top_left_x":889,"top_left_y":1555,"width":398,"height":55},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47ddf36f239f430e8cfcafd5f7b9f500","type":"math","conversion_output":true,"text":"\\[\n\\operatorname{Corr}\\left(Y_{ik}, Y_{im}\\right)=\\rho_{km}, k \\neq m\n\\]","text_display":"\n\\[\n\\operatorname{Corr}\\left(Y_{ik}, Y_{im}\\right)=\\rho_{km}, k \\neq m\n\\]","confidence":0.3636970520019531,"confidence_rate":0.9817783492656293},{"cnt":[[486,1646],[1704,1646],[1704,1691],[486,1691]],"region":{"top_left_x":485,"top_left_y":1645,"width":1219,"height":46},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dee4d96ba8384befa9dafeb126d3ae2e","type":"text","conversion_output":true,"text":"For the repeated measures model of mRS 0-1, a temporal correlation structure","text_display":"\n\nFor the repeated measures model of mRS 0-1, a temporal correlation structure","confidence":0.9746334494557232,"confidence_rate":0.999704712250298},{"cnt":[[486,1689],[1697,1689],[1697,1734],[486,1734]],"region":{"top_left_x":485,"top_left_y":1688,"width":1213,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3db478cb3ada41bbbab52415c0eb7759","type":"text","conversion_output":true,"text":"may be chosen instead, which takes into account the distance in time between","text_display":" may be chosen instead, which takes into account the distance in time between","confidence":1,"confidence_rate":1},{"cnt":[[486,1732],[862,1732],[862,1777],[486,1777]],"region":{"top_left_x":485,"top_left_y":1731,"width":377,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c47f017be8154b13b680bf781551f8b2","type":"text","conversion_output":true,"text":"the repeated measures:","text_display":" the repeated measures:","confidence":1,"confidence_rate":1},{"cnt":[[920,1792],[1257,1792],[1257,1854],[920,1854]],"region":{"top_left_x":919,"top_left_y":1791,"width":338,"height":64},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfe5b4a24c804081a074ec2cdf01fd0b","type":"math","conversion_output":true,"text":"\\[\n\\operatorname{Corr}\\left(Y_{i 1}, Y_{i 2}\\right)=\\rho^{|d 1-d 2|}\n\\]","text_display":"\n\\[\n\\operatorname{Corr}\\left(Y_{i 1}, Y_{i 2}\\right)=\\rho^{|d 1-d 2|}\n\\]","confidence":0.9409747123718262,"confidence_rate":0.9990498421095606},{"cnt":[[486,1886],[1553,1886],[1553,1934],[486,1934]],"region":{"top_left_x":485,"top_left_y":1886,"width":1069,"height":48},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7c02ba5fc7584a9d9754a6254e47c90b","type":"text","conversion_output":true,"text":"where d 1 and d 2 are study days of Day 30 and Day 90 assessments.","text_display":"\nwhere d 1 and d 2 are study days of Day 30 and Day 90 assessments.","confidence":0.9990234375,"confidence_rate":0.9999887697222805},{"cnt":[[434,1959],[1626,1959],[1626,2004],[434,2004]],"region":{"top_left_x":433,"top_left_y":1959,"width":1194,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"170e1173a34f4b089b7664cd51e66532","type":"text","conversion_output":true,"text":"Estimation will be carried out by the generalized estimating equaltions (GEE).","text_display":"\nEstimation will be carried out by the generalized estimating equaltions (GEE).","confidence":0.9931697845458984,"confidence_rate":0.9999174293352076},{"cnt":[[430,2050],[1257,2050],[1257,2099],[430,2099]],"region":{"top_left_x":429,"top_left_y":2049,"width":828,"height":51},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1502d32f23064f57a7db414071c9c764","type":"section_header","conversion_output":false,"children_ids":["724a5e1469a2461c8b46ec5ab706d6b6"],"text":"","text_display":""},{"cnt":[[434,2054],[1248,2054],[1248,2095],[434,2095]],"region":{"top_left_x":433,"top_left_y":2053,"width":816,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"724a5e1469a2461c8b46ec5ab706d6b6","type":"text","conversion_output":true,"parent_id":"1502d32f23064f57a7db414071c9c764","text":"Adjusted Risk Difference with logistic regression","text_display":"\n\n\\section*{Adjusted Risk Difference with logistic regression}","confidence":1,"confidence_rate":1},{"cnt":[[434,2144],[1714,2144],[1714,2189],[434,2189]],"region":{"top_left_x":433,"top_left_y":2144,"width":1282,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc554c4267a14f6e84791d951c578b70","type":"text","conversion_output":true,"text":"The logistic regression model defined for the mRS 0-1 outcome provides estimates","text_display":"\n\nThe logistic regression model defined for the mRS 0-1 outcome provides estimates","confidence":0.9975595474243164,"confidence_rate":0.9999712541151248},{"cnt":[[434,2196],[1571,2196],[1571,2239],[434,2239]],"region":{"top_left_x":433,"top_left_y":2195,"width":1138,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"09091f56d4fd4379b112cfa5de8a0bb4","type":"text","conversion_output":true,"text":"of the odds of a favorable outcome. These odds can then be converted to","text_display":" of the odds of a favorable outcome. These odds can then be converted to","confidence":1,"confidence_rate":1},{"cnt":[[434,2247],[1695,2247],[1695,2295],[434,2295]],"region":{"top_left_x":433,"top_left_y":2247,"width":1263,"height":48},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87679c3dd6414d1688aa0b9831dd4462","type":"text","conversion_output":true,"text":"probabilities, and thus the risk difference can be obtained as a non-linear contrast","text_display":" probabilities, and thus the risk difference can be obtained as a non-linear contrast","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98d278e5b731451bacd8a13380a7387f","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"263b78d29192446d88beb857c50c7f00","type":"text","conversion_output":true,"text":"47/ML29093","text_display":"\n47/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f24535c928e54076b8e2053a137dedde","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4531a5fa91154908b4096d09d413983f","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9941506325279192,"confidence_rate":0.9999097495800716},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0b4989c60b454e87b001c3e5ec6c58df","type":"page_info","conversion_output":false,"text":"808/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-49","page":49,"lines":[{"cnt":[[434,449],[1725,449],[1725,492],[434,492]],"region":{"top_left_x":433,"top_left_y":449,"width":1293,"height":43},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c9dc58ffc894124a6b8a728e774e91d","type":"text","conversion_output":true,"text":"between the treatment groups. Linearization of this contrast provides an estimate of","text_display":"\nbetween the treatment groups. Linearization of this contrast provides an estimate of","confidence":1,"confidence_rate":1},{"cnt":[[434,498],[1446,498],[1446,544],[434,544]],"region":{"top_left_x":433,"top_left_y":498,"width":1013,"height":46},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"608013764a4e4e1e9eaafa81cfd9908b","type":"text","conversion_output":true,"text":"the standard error, the approximation known as the delta method.","text_display":" the standard error, the approximation known as the delta method.","confidence":1,"confidence_rate":1},{"cnt":[[434,593],[1687,593],[1687,638],[434,638]],"region":{"top_left_x":433,"top_left_y":592,"width":1254,"height":47},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"642961d6e1294170a26ee2388e804224","type":"text","conversion_output":true,"text":"This approach can be implemented with SAS PROC NLMIXED. Here is a sample","text_display":"\n\nThis approach can be implemented with SAS PROC NLMIXED. Here is a sample","confidence":0.99853515625,"confidence_rate":0.999980962289239},{"cnt":[[434,645],[526,645],[526,681],[434,681]],"region":{"top_left_x":433,"top_left_y":644,"width":94,"height":38},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"81eb62cf3d24404692ef436bcbba782e","type":"text","conversion_output":true,"text":"code:","text_display":" code:","confidence":1,"confidence_rate":1},{"cnt":[[430,724],[1261,724],[1261,995],[430,995]],"region":{"top_left_x":429,"top_left_y":724,"width":833,"height":271},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"77db1ac9ea8c4eeeac136b9a8dde0afc","type":"diagram","conversion_output":false,"children_ids":["f384b89476254ca7abf9f9eb4a41edf1","b4a03ad8bea8478d902f17132815b931","e1059b63dff64d689a6da8603e6c3535","7af78331c19f4e2b9131d31bf3004380","25a035a9793c46ce8ca12eadcf73af15","d3470018950040a9a522d1444cac5ae2","ecc4cdf5895b4c05a11eb1d1fff47b86","5cc3ed8884c34327bb6391459e1ac5e3"],"text":"","text_display":"","subtype":"algorithm"},{"cnt":[[434,730],[816,730],[816,763],[434,763]],"region":{"top_left_x":433,"top_left_y":730,"width":384,"height":33},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f384b89476254ca7abf9f9eb4a41edf1","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"proc nlmixed data=MRS;","text_display":"\n```\nproc nlmixed data=MRS;","confidence":1,"confidence_rate":1},{"cnt":[[486,761],[1233,761],[1233,793],[486,793]],"region":{"top_left_x":485,"top_left_y":760,"width":749,"height":33},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b4a03ad8bea8478d902f17132815b931","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"eta = b0+b1* (TRTPN=1) +b2*AGE+b3*OTT+b4 *NIHSS;","text_display":"\n    eta = b0+b1* (TRTPN=1) +b2*AGE+b3*OTT+b4 *NIHSS;","confidence":0.1874159263177547,"confidence_rate":0.967701253926652},{"cnt":[[486,795],[799,795],[799,827],[486,827]],"region":{"top_left_x":485,"top_left_y":794,"width":315,"height":34},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e1059b63dff64d689a6da8603e6c3535","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"p=1/(1+exp(-eta));","text_display":"\n    p=1/(1+exp(-eta));","confidence":1,"confidence_rate":1},{"cnt":[[486,829],[973,829],[973,862],[486,862]],"region":{"top_left_x":485,"top_left_y":829,"width":489,"height":33},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7af78331c19f4e2b9131d31bf3004380","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"model respn ~ binomial(1,p);","text_display":"\n    model respn ~ binomial(1,p);","confidence":1,"confidence_rate":1},{"cnt":[[486,859],[943,859],[943,892],[486,892]],"region":{"top_left_x":485,"top_left_y":859,"width":459,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"25a035a9793c46ce8ca12eadcf73af15","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"estimate \"tPA vs. Aspirin\"","text_display":"\n    estimate \"tPA vs. Aspirin\"","confidence":1,"confidence_rate":1},{"cnt":[[541,889],[1257,889],[1257,926],[541,926]],"region":{"top_left_x":541,"top_left_y":889,"width":716,"height":37},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d3470018950040a9a522d1444cac5ae2","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"1/(1+exp(-(b0+b1+b2*&m1+b3* &m2+b4* &m3)) -","text_display":"\n        1/(1+exp(-(b0+b1+b2*&m1+b3* &m2+b4* &m3)) -","confidence":0.4539170873494755,"confidence_rate":0.9829761215490531},{"cnt":[[541,924],[1182,924],[1182,958],[541,958]],"region":{"top_left_x":541,"top_left_y":923,"width":641,"height":36},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ecc4cdf5895b4c05a11eb1d1fff47b86","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"1/(1+exp(-(b0+b2* &m1+b3* &m2+b4 * &m3));","text_display":"\n        1/(1+exp(-(b0+b2* &m1+b3* &m2+b4 * &m3));","confidence":0.39870195584910184,"confidence_rate":0.979318201888454},{"cnt":[[434,962],[507,962],[507,988],[434,988]],"region":{"top_left_x":433,"top_left_y":962,"width":75,"height":27},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"5cc3ed8884c34327bb6391459e1ac5e3","type":"code","conversion_output":true,"parent_id":"77db1ac9ea8c4eeeac136b9a8dde0afc","text":"run;","text_display":"\nrun;\n```\n","confidence":1,"confidence_rate":1},{"cnt":[[434,1031],[1622,1031],[1622,1072],[434,1072]],"region":{"top_left_x":433,"top_left_y":1031,"width":1190,"height":42},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"617848f084f54da999af83430fc55fd6","type":"text","conversion_output":true,"text":"where TRTPN=1 selects tPA treatment, and macro variables m 1 , m 2 and m 3","text_display":"\nwhere TRTPN=1 selects tPA treatment, and macro variables m 1 , m 2 and m 3","confidence":0.4048519498765826,"confidence_rate":0.99000326032009},{"cnt":[[434,1083],[1463,1083],[1463,1128],[434,1128]],"region":{"top_left_x":433,"top_left_y":1082,"width":1031,"height":46},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a2284c5c1b3e43e598053d3f084acfb9","type":"text","conversion_output":true,"text":"resolve to the mean values of AGE, OTT and NIHSS, respectively.","text_display":" resolve to the mean values of AGE, OTT and NIHSS, respectively.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58b921708412410e9f6cddd7d2b88034","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3fe26a2fb67d485797c82b476d2e87f7","type":"page_info","conversion_output":false,"text":"48/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"11a4d76787bc4b45933452eb5b30dbfd","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"482815d3accf4e1d911d208046838dcf","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9936649702746081,"confidence_rate":0.9999022327614051},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d24684befb6452396eb4a11ec6fa901","type":"page_info","conversion_output":false,"text":"809/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-50","page":50,"lines":[{"cnt":[[503,438],[1678,438],[1678,531],[503,531]],"region":{"top_left_x":502,"top_left_y":438,"width":1176,"height":93},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fcb6fd7ac094e8cbaf573ed85e94b50","type":"section_header","conversion_output":false,"children_ids":["023abd32b4e444e29a638753f5e79945","fabca892c6e64a78866a83397bf9f76b"],"text":"","text_display":""},{"cnt":[[988,443],[1188,443],[1188,483],[988,483]],"region":{"top_left_x":988,"top_left_y":442,"width":201,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"023abd32b4e444e29a638753f5e79945","type":"text","conversion_output":true,"parent_id":"8fcb6fd7ac094e8cbaf573ed85e94b50","text":"Appendix E","text_display":"\n\n\\section*{Appendix E","confidence":1,"confidence_rate":1},{"cnt":[[505,486],[1674,486],[1674,526],[505,526]],"region":{"top_left_x":504,"top_left_y":485,"width":1170,"height":42},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fabca892c6e64a78866a83397bf9f76b","type":"text","conversion_output":true,"parent_id":"8fcb6fd7ac094e8cbaf573ed85e94b50","text":"Documentation of Additional Analyses Performed after Database Lock","text_display":" Documentation of Additional Analyses Performed after Database Lock}","confidence":1,"confidence_rate":1},{"cnt":[[430,589],[1315,589],[1315,638],[430,638]],"region":{"top_left_x":429,"top_left_y":588,"width":886,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3b8d619112c04c3a8bbcc44dea9812ce","type":"section_header","conversion_output":false,"children_ids":["a4ca9b86fc654cefa1ca046120384e6b"],"text":"","text_display":""},{"cnt":[[434,593],[1308,593],[1308,634],[434,634]],"region":{"top_left_x":433,"top_left_y":592,"width":876,"height":42},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4ca9b86fc654cefa1ca046120384e6b","type":"text","conversion_output":true,"parent_id":"3b8d619112c04c3a8bbcc44dea9812ce","text":"Additional analysis for the primary outcome mRS 0-1","text_display":"\n\n\\section*{Additional analysis for the primary outcome mRS 0-1}","confidence":0.6640222827090838,"confidence_rate":0.9934178935283626},{"cnt":[[434,679],[1566,679],[1566,724],[434,724]],"region":{"top_left_x":433,"top_left_y":678,"width":1134,"height":47},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"518fafdc71024685a0b54d5414aeb1e1","type":"text","conversion_output":true,"text":"Baseline imbalance as measured by standardized difference in additional","text_display":"\n\nBaseline imbalance as measured by standardized difference in additional","confidence":1,"confidence_rate":1},{"cnt":[[434,730],[1725,730],[1725,776],[434,776]],"region":{"top_left_x":433,"top_left_y":730,"width":1293,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93d3434f04d8427e876440bffdb2ba0c","type":"text","conversion_output":true,"text":"explanatory variables listed in Table \\(6\\) will be explored. The standardized difference","text_display":" explanatory variables listed in Table \\(6\\) will be explored. The standardized difference","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[434,784],[1644,784],[1644,827],[434,827]],"region":{"top_left_x":433,"top_left_y":784,"width":1211,"height":44},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca868fec36be431289653022aad3301c","type":"text","conversion_output":true,"text":"can be used to compare the mean of continuous and binary variables between","text_display":" can be used to compare the mean of continuous and binary variables between","confidence":1,"confidence_rate":1},{"cnt":[[434,838],[1727,838],[1727,879],[434,879]],"region":{"top_left_x":433,"top_left_y":837,"width":1295,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9d454bc567df4bba9312b45ef070ddaf","type":"text","conversion_output":true,"text":"treatment groups. For a continuous covariate, the standardized difference is defined","text_display":" treatment groups. For a continuous covariate, the standardized difference is defined","confidence":1,"confidence_rate":1},{"cnt":[[434,889],[1676,889],[1676,930],[434,930]],"region":{"top_left_x":433,"top_left_y":889,"width":1243,"height":42},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"047f613bdfb649a199459547279fe692","type":"text","conversion_output":true,"text":"as the difference in the sample means of treatment groups divided by the pooled","text_display":" as the difference in the sample means of treatment groups divided by the pooled","confidence":1,"confidence_rate":1},{"cnt":[[434,941],[1629,941],[1629,982],[434,982]],"region":{"top_left_x":433,"top_left_y":941,"width":1196,"height":41},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"27de7cc02ead46d285a7f99c7691c155","type":"text","conversion_output":true,"text":"standard error; see Austin (1) for the mathematical formula. The standardized","text_display":" standard error; see Austin (1) for the mathematical formula. The standardized","confidence":0.99951171875,"confidence_rate":0.9999940439141021},{"cnt":[[434,993],[1601,993],[1601,1033],[434,1033]],"region":{"top_left_x":433,"top_left_y":992,"width":1168,"height":42},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"111d27576a9144ba9c2ca83e5b03b8da","type":"text","conversion_output":true,"text":"difference compares the difference in means in units of the pooled standard","text_display":" difference compares the difference in means in units of the pooled standard","confidence":0.9990234375,"confidence_rate":0.9999877870789805},{"cnt":[[434,1044],[1609,1044],[1609,1085],[434,1085]],"region":{"top_left_x":433,"top_left_y":1044,"width":1177,"height":41},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e4d132d769934a7fba8956e074491429","type":"text","conversion_output":true,"text":"deviation. Furthermore, it is not influenced by sample size and allows for the","text_display":" deviation. Furthermore, it is not influenced by sample size and allows for the","confidence":1,"confidence_rate":1},{"cnt":[[434,1096],[1732,1096],[1732,1139],[434,1139]],"region":{"top_left_x":433,"top_left_y":1095,"width":1299,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"705caccf97eb427197f173d917a640f7","type":"text","conversion_output":true,"text":"comparison of the relative balance of variables measured in different units. Although","text_display":" comparison of the relative balance of variables measured in different units. Although","confidence":1,"confidence_rate":1},{"cnt":[[434,1147],[1738,1147],[1738,1190],[434,1190]],"region":{"top_left_x":433,"top_left_y":1147,"width":1306,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80b004c842ed4e47aafacfaf804f2fc5","type":"text","conversion_output":true,"text":"there is no universally agreed upon criterion as to what threshold of the standardized","text_display":" there is no universally agreed upon criterion as to what threshold of the standardized","confidence":1,"confidence_rate":1},{"cnt":[[434,1199],[1691,1199],[1691,1242],[434,1242]],"region":{"top_left_x":433,"top_left_y":1198,"width":1258,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"02721a7fb7844a90bc9b4e77723b0237","type":"text","conversion_output":true,"text":"difference can be used to indicate important imbalance, a standardized difference","text_display":" difference can be used to indicate important imbalance, a standardized difference","confidence":1,"confidence_rate":1},{"cnt":[[434,1250],[1738,1250],[1738,1296],[434,1296]],"region":{"top_left_x":433,"top_left_y":1250,"width":1306,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3e9eb29871734360a4001af28bfa7081","type":"text","conversion_output":true,"text":"that is less than 0.1 has been taken to indicate a negligible difference in the mean or","text_display":" that is less than 0.1 has been taken to indicate a negligible difference in the mean or","confidence":0.9990234375,"confidence_rate":0.9999897154250147},{"cnt":[[434,1302],[1302,1302],[1302,1347],[434,1347]],"region":{"top_left_x":433,"top_left_y":1301,"width":869,"height":47},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d3d5053547674627936bea18cad09d99","type":"text","conversion_output":true,"text":"prevalence of a covariate between treatment groups (1).","text_display":" prevalence of a covariate between treatment groups (1).","confidence":0.94775390625,"confidence_rate":0.9991060597530271},{"cnt":[[434,1396],[1734,1396],[1734,1437],[434,1437]],"region":{"top_left_x":433,"top_left_y":1396,"width":1301,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92c9091d945647dbb8aed4a675cd3136","type":"text","conversion_output":true,"text":"The impact of baseline imbalance if present in at least one candidate variable will be","text_display":"\n\nThe impact of baseline imbalance if present in at least one candidate variable will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1448],[1725,1448],[1725,1491],[434,1491]],"region":{"top_left_x":433,"top_left_y":1448,"width":1293,"height":44},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"146d7a1783964fc39b4d33b8fa8a4ee0","type":"text","conversion_output":true,"text":"evaluated on the adjusted risk difference for the primary efficacy endpoint through a","text_display":" evaluated on the adjusted risk difference for the primary efficacy endpoint through a","confidence":1,"confidence_rate":1},{"cnt":[[434,1500],[1618,1500],[1618,1545],[434,1545]],"region":{"top_left_x":433,"top_left_y":1499,"width":1185,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"868973c1bfbd4ba9ab8af0a25bfc8c47","type":"text","conversion_output":true,"text":"propensity score approach. Specifically, when there is at least one candidate","text_display":" propensity score approach. Specifically, when there is at least one candidate","confidence":0.99951171875,"confidence_rate":0.9999940439141021},{"cnt":[[434,1551],[1721,1551],[1721,1596],[434,1596]],"region":{"top_left_x":433,"top_left_y":1551,"width":1288,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"92835db0d02d4dda826b55cf51e0aaf1","type":"text","conversion_output":true,"text":"variable that shows a standardized difference larger than 0.1 , propensity scores will","text_display":" variable that shows a standardized difference larger than 0.1 , propensity scores will","confidence":1,"confidence_rate":1},{"cnt":[[434,1605],[1648,1605],[1648,1648],[434,1648]],"region":{"top_left_x":433,"top_left_y":1604,"width":1215,"height":44},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b8df8eec786246a7b3e7061eceaf4ab7","type":"text","conversion_output":true,"text":"be generated using a logistic regression model with the treatment group as the","text_display":" be generated using a logistic regression model with the treatment group as the","confidence":1,"confidence_rate":1},{"cnt":[[434,1656],[1708,1656],[1708,1699],[434,1699]],"region":{"top_left_x":433,"top_left_y":1656,"width":1276,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20bc86698bd9449182f2e228513bce63","type":"text","conversion_output":true,"text":"response variable and all variables listed in Table 6 as independent variables. The","text_display":" response variable and all variables listed in Table 6 as independent variables. The","confidence":0.99072265625,"confidence_rate":0.9998975805602445},{"cnt":[[434,1710],[1693,1710],[1693,1751],[434,1751]],"region":{"top_left_x":433,"top_left_y":1710,"width":1260,"height":41},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8e041cdbe107455a9734d50a77510206","type":"text","conversion_output":true,"text":"estimated propensity scores will then be included as an additional covariate in the","text_display":" estimated propensity scores will then be included as an additional covariate in the","confidence":1,"confidence_rate":1},{"cnt":[[434,1762],[1631,1762],[1631,1803],[434,1803]],"region":{"top_left_x":433,"top_left_y":1761,"width":1198,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7286a3782f44946b844555cd0051ca2","type":"text","conversion_output":true,"text":"linear regression model performed for the primary outcome. The adjusted risk","text_display":" linear regression model performed for the primary outcome. The adjusted risk","confidence":1,"confidence_rate":1},{"cnt":[[434,1813],[1742,1813],[1742,1854],[434,1854]],"region":{"top_left_x":433,"top_left_y":1813,"width":1310,"height":42},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1150389e76d4b599c9aaa415f480f4e","type":"text","conversion_output":true,"text":"difference will be reported from this model. Note that age, baseline NIHSS and onset","text_display":" difference will be reported from this model. Note that age, baseline NIHSS and onset","confidence":1,"confidence_rate":1},{"cnt":[[434,1865],[1712,1865],[1712,1906],[434,1906]],"region":{"top_left_x":433,"top_left_y":1864,"width":1280,"height":42},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f100fcd9b50d432faca2d3dd9692ca4d","type":"text","conversion_output":true,"text":"time to treatment will not be included in the propensity score model, but instead will","text_display":" time to treatment will not be included in the propensity score model, but instead will","confidence":1,"confidence_rate":1},{"cnt":[[434,1916],[1154,1916],[1154,1962],[434,1962]],"region":{"top_left_x":433,"top_left_y":1916,"width":721,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9de35b437b1e40bfbc23947e3289b626","type":"text","conversion_output":true,"text":"be explicitly adjusted for in the analysis model.","text_display":" be explicitly adjusted for in the analysis model.","confidence":1,"confidence_rate":1},{"cnt":[[434,2011],[1661,2011],[1661,2052],[434,2052]],"region":{"top_left_x":433,"top_left_y":2010,"width":1228,"height":42},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf68a4706e3b43a3b6b28f5826cad691","type":"text","conversion_output":true,"text":"Missing covariates will be imputed so that all patients have the propensity score","text_display":"\n\nMissing covariates will be imputed so that all patients have the propensity score","confidence":1,"confidence_rate":1},{"cnt":[[434,2062],[1708,2062],[1708,2103],[434,2103]],"region":{"top_left_x":433,"top_left_y":2062,"width":1276,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f686120e62f94ea7b673e49dd0e49706","type":"text","conversion_output":true,"text":"defined. Continuous covariates will be imputed with their mean values. Categorical","text_display":" defined. Continuous covariates will be imputed with their mean values. Categorical","confidence":1,"confidence_rate":1},{"cnt":[[434,2114],[1693,2114],[1693,2155],[434,2155]],"region":{"top_left_x":433,"top_left_y":2114,"width":1260,"height":41},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f843aa67e6914261858aeecb37f7276d","type":"text","conversion_output":true,"text":"covariates will be collapsed to avoid rare categories. The least frequent categories","text_display":" covariates will be collapsed to avoid rare categories. The least frequent categories","confidence":0.9970703125,"confidence_rate":0.9999670343924248},{"cnt":[[434,2166],[1656,2166],[1656,2206],[434,2206]],"region":{"top_left_x":433,"top_left_y":2165,"width":1224,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a1ac626e2e9143b1815447bad9d9a8f6","type":"text","conversion_output":true,"text":"will be merged together until there are at least 10 subjects per category and the","text_display":" will be merged together until there are at least 10 subjects per category and the","confidence":1,"confidence_rate":1},{"cnt":[[434,2217],[1729,2217],[1729,2260],[434,2260]],"region":{"top_left_x":433,"top_left_y":2217,"width":1297,"height":44},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"003e2f0ed78d423ab8f02e7c0fdccc6a","type":"text","conversion_output":true,"text":"propensity score model has no estimation problems. If there is a substantial number","text_display":" propensity score model has no estimation problems. If there is a substantial number","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[1201,2368],[1201,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2690343e68034d1289adaa0cf84c58a9","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[599,2402],[599,2434],[434,2434]],"region":{"top_left_x":433,"top_left_y":2401,"width":167,"height":34},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7413f01fc1d4131b9d14d3775bf88d1","type":"page_info","conversion_output":false,"text":"49/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2434],[1044,2434]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":34},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cecf0a91e9494266aed6cb60d3947150","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da96b339837841bca00d65561c5771eb","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922086966757888,"confidence_rate":0.9998796716383385},{"cnt":[[372,2608],[692,2608],[692,2640],[372,2640]],"region":{"top_left_x":371,"top_left_y":2608,"width":321,"height":33},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"80f6e5c26c9442cab0864605cd262502","type":"page_info","conversion_output":false,"text":"810/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-51","page":51,"lines":[{"cnt":[[434,449],[1596,449],[1596,492],[434,492]],"region":{"top_left_x":433,"top_left_y":449,"width":1164,"height":43},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd9ba1ac908541c898daf67dd68034cc","type":"text","conversion_output":true,"text":"of missing values in a categorical variable, missing may be considered as a","text_display":"\nof missing values in a categorical variable, missing may be considered as a","confidence":1,"confidence_rate":1},{"cnt":[[434,501],[1510,501],[1510,544],[434,544]],"region":{"top_left_x":433,"top_left_y":500,"width":1078,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e3687a7c33248ea8c3cd189c9d9dd7e","type":"text","conversion_output":true,"text":"standalone category for the purpose of generating a propensity score.","text_display":" standalone category for the purpose of generating a propensity score.","confidence":1,"confidence_rate":1},{"cnt":[[657,773],[1519,773],[1519,866],[657,866]],"region":{"top_left_x":657,"top_left_y":773,"width":862,"height":93},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12615c72dc05430da7f41f6ce5c028c6","type":"figure_label","conversion_output":false,"children_ids":["251694a2a7344a66b3df9c8b0a5ec176","2fd181289ca441e8acfe170656687da2"],"text":"","text_display":""},{"cnt":[[1023,780],[1154,780],[1154,814],[1023,814]],"region":{"top_left_x":1022,"top_left_y":779,"width":132,"height":36},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"251694a2a7344a66b3df9c8b0a5ec176","type":"text","conversion_output":false,"parent_id":"12615c72dc05430da7f41f6ce5c028c6","text":"Table 6","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[664,825],[1515,825],[1515,864],[664,864]],"region":{"top_left_x":663,"top_left_y":825,"width":852,"height":39},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fd181289ca441e8acfe170656687da2","type":"text","conversion_output":false,"parent_id":"12615c72dc05430da7f41f6ce5c028c6","text":"Baseline Characteristics to be Evaluated for Imbalance","text_display":"","confidence":0.99853515625,"confidence_rate":0.9999751542462456},{"cnt":[[432,885],[1747,885],[1747,1394],[432,1394]],"region":{"top_left_x":431,"top_left_y":885,"width":1316,"height":510},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ab99f96bb3324c05ae207f115ee267dc","type":"table","conversion_output":true,"children_ids":["8b600a9dd94b4147beca7debf61e555e","8e7626e7385b4f678eb1bcec60888fb5","484682924381471b8c1876984580d706","4b058df9d2404d579f3614d2945a8ac6","4550ec3976fe4a50b5b6bbca7e0f9b36","816024d7b59141ddbe32c18b53beea39","81f4e55f1bf045f79a83c48b6389b0fd","33fc37102c674689b5a49fbc1de2abea","b79a133acf0d474b832feca017babb9a","bdc045adfef5428686517a5481c626b0","78b68283640c41948dc492cca5abe09a","49fc2f7f38ae40fc8a7e203e003cfa49","690a55977ecc4f29b41f891e56788b2f","3d4aab5297ce4402b6f2cd9f6eaed622","65840e8573b84d689562390b6cceff1c","4a914ecb06224bf6b9eee248039fa44e","5088590733b74f44b45d9ceb645333e5","f052b19003264b41a91e7bf2f8d42459","a598dbb2d8824e398d4732f79bd92a87","2637f8a558204ac18feac03272aca58d","08a04e79fc3e425b87886b4b5242f0aa","6de8b0aecc4246ee8a733884adb60ab8","2fd66bc80c594c72b7b6967deab2ff84","f799f4aa349c4fa68ca88558d7cb8997","d0ac5e863c014b1bb78bf8a002156027","b412ea2a6fe349f1ab050a89676848bc","e00d152667ed4be0aa7fa88923fa2fd9"],"selected_labels":["12615c72dc05430da7f41f6ce5c028c6"],"text":"\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|c|}{} \\\\\n\\hline Sex & Prior anti-platelet drug use \\\\\n\\hline Race & Prior anti-coagulant drug use \\\\\n\\hline Ethnicity & Baseline glucose \\\\\n\\hline Smoking & Baseline systolic blood pressure \\\\\n\\hline Medical History & Baseline coagulation test: INR \\\\\n\\hline - Hypertension & \\\\\n\\hline - Diabetes Mellitus & \\\\\n\\hline - Atrial Fibrillation & \\\\\n\\hline - Stroke & \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 6\nBaseline Characteristics to be Evaluated for Imbalance}\n\\begin{tabular}{|l|l|}\n\\hline \\multicolumn{2}{|c|}{} \\\\\n\\hline Sex & Prior anti-platelet drug use \\\\\n\\hline Race & Prior anti-coagulant drug use \\\\\n\\hline Ethnicity & Baseline glucose \\\\\n\\hline Smoking & Baseline systolic blood pressure \\\\\n\\hline Medical History & Baseline coagulation test: INR \\\\\n\\hline - Hypertension & \\\\\n\\hline - Diabetes Mellitus & \\\\\n\\hline - Atrial Fibrillation & \\\\\n\\hline - Stroke & \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":1,"confidence_rate":1},{"cnt":[[441,885],[699,885],[699,1395],[441,1395]],"region":{"top_left_x":441,"top_left_y":885,"width":259,"height":511},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8b600a9dd94b4147beca7debf61e555e","type":"table_column","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[1093,885],[1519,885],[1519,1395],[1093,1395]],"region":{"top_left_x":1092,"top_left_y":885,"width":427,"height":511},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8e7626e7385b4f678eb1bcec60888fb5","type":"table_column","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,891],[1746,888],[1746,938],[431,940]],"region":{"top_left_x":430,"top_left_y":888,"width":1316,"height":53},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"484682924381471b8c1876984580d706","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,950],[1748,950],[1748,990],[431,990]],"region":{"top_left_x":431,"top_left_y":950,"width":1317,"height":40},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4b058df9d2404d579f3614d2945a8ac6","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,998],[1746,998],[1746,1040],[431,1040]],"region":{"top_left_x":431,"top_left_y":998,"width":1315,"height":42},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4550ec3976fe4a50b5b6bbca7e0f9b36","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1047],[1746,1047],[1746,1090],[431,1090]],"region":{"top_left_x":431,"top_left_y":1046,"width":1315,"height":44},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"816024d7b59141ddbe32c18b53beea39","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1096],[1746,1096],[1746,1139],[431,1139]],"region":{"top_left_x":431,"top_left_y":1096,"width":1315,"height":44},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"81f4e55f1bf045f79a83c48b6389b0fd","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1146],[1746,1146],[1746,1189],[431,1189]],"region":{"top_left_x":431,"top_left_y":1146,"width":1315,"height":44},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"33fc37102c674689b5a49fbc1de2abea","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1198],[1746,1198],[1746,1237],[431,1237]],"region":{"top_left_x":431,"top_left_y":1197,"width":1315,"height":41},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b79a133acf0d474b832feca017babb9a","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1246],[1746,1246],[1746,1282],[431,1282]],"region":{"top_left_x":431,"top_left_y":1245,"width":1315,"height":38},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bdc045adfef5428686517a5481c626b0","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1294],[1746,1294],[1746,1330],[431,1330]],"region":{"top_left_x":431,"top_left_y":1294,"width":1315,"height":37},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"78b68283640c41948dc492cca5abe09a","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[431,1346],[1746,1346],[1746,1378],[431,1378]],"region":{"top_left_x":431,"top_left_y":1345,"width":1315,"height":34},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"49fc2f7f38ae40fc8a7e203e003cfa49","type":"table_row","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":""},{"cnt":[[441,892],[1516,892],[1516,938],[441,938]],"region":{"top_left_x":441,"top_left_y":891,"width":1075,"height":48},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"690a55977ecc4f29b41f891e56788b2f","type":"table_spanning_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"","text_display":"","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":2},{"cnt":[[445,954],[500,954],[500,985],[445,985]],"region":{"top_left_x":444,"top_left_y":953,"width":56,"height":32},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d4aab5297ce4402b6f2cd9f6eaed622","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Sex","text_display":"Sex","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,954],[1436,954],[1436,986],[1094,986]],"region":{"top_left_x":1094,"top_left_y":953,"width":343,"height":34},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"65840e8573b84d689562390b6cceff1c","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Prior anti-platelet drug use","text_display":"Prior anti-platelet drug use","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,1002],[515,1002],[515,1031],[445,1031]],"region":{"top_left_x":444,"top_left_y":1001,"width":72,"height":31},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a914ecb06224bf6b9eee248039fa44e","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Race","text_display":"Race","cell_row":2,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1002],[1471,1002],[1471,1038],[1094,1038]],"region":{"top_left_x":1094,"top_left_y":1001,"width":377,"height":37},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5088590733b74f44b45d9ceb645333e5","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Prior anti-coagulant drug use","text_display":"Prior anti-coagulant drug use","cell_row":2,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,1053],[558,1053],[558,1086],[445,1086]],"region":{"top_left_x":444,"top_left_y":1053,"width":115,"height":34},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f052b19003264b41a91e7bf2f8d42459","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Ethnicity","text_display":"Ethnicity","cell_row":3,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1053],[1318,1053],[1318,1086],[1094,1086]],"region":{"top_left_x":1094,"top_left_y":1053,"width":224,"height":34},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a598dbb2d8824e398d4732f79bd92a87","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Baseline glucose","text_display":"Baseline glucose","cell_row":3,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,1102],[560,1102],[560,1134],[445,1134]],"region":{"top_left_x":444,"top_left_y":1101,"width":116,"height":34},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2637f8a558204ac18feac03272aca58d","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Smoking","text_display":"Smoking","cell_row":4,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1102],[1512,1102],[1512,1134],[1094,1134]],"region":{"top_left_x":1094,"top_left_y":1101,"width":419,"height":34},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"08a04e79fc3e425b87886b4b5242f0aa","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Baseline systolic blood pressure","text_display":"Baseline systolic blood pressure","cell_row":4,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[445,1150],[646,1150],[646,1184],[445,1184]],"region":{"top_left_x":444,"top_left_y":1149,"width":202,"height":36},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6de8b0aecc4246ee8a733884adb60ab8","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Medical History","text_display":"Medical History","cell_row":5,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1094,1150],[1486,1150],[1486,1184],[1094,1184]],"region":{"top_left_x":1094,"top_left_y":1149,"width":393,"height":36},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fd66bc80c594c72b7b6967deab2ff84","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"Baseline coagulation test: INR","text_display":"Baseline coagulation test: INR","cell_row":5,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[450,1198],[644,1198],[644,1234],[450,1234]],"region":{"top_left_x":449,"top_left_y":1197,"width":196,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f799f4aa349c4fa68ca88558d7cb8997","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"- Hypertension","text_display":"- Hypertension","cell_row":6,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[452,1248],[694,1248],[694,1279],[452,1279]],"region":{"top_left_x":451,"top_left_y":1247,"width":243,"height":32},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0ac5e863c014b1bb78bf8a002156027","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"- Diabetes Mellitus","text_display":"- Diabetes Mellitus","cell_row":7,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[452,1298],[680,1298],[680,1327],[452,1327]],"region":{"top_left_x":451,"top_left_y":1297,"width":230,"height":30},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b412ea2a6fe349f1ab050a89676848bc","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"- Atrial Fibrillation","text_display":"- Atrial Fibrillation","cell_row":8,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[452,1349],[556,1349],[556,1377],[452,1377]],"region":{"top_left_x":451,"top_left_y":1349,"width":106,"height":28},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e00d152667ed4be0aa7fa88923fa2fd9","type":"simple_cell","conversion_output":false,"parent_id":"ab99f96bb3324c05ae207f115ee267dc","text":"- Stroke","text_display":"- Stroke","cell_row":9,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0d4518cb42cc40d29791b77e20996230","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"70bc38d1480c4ae9983cf54b493d041d","type":"page_info","conversion_output":false,"text":"50/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"bd451271673a48a78f615dec70ae128f","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1416,2574],[1416,2615],[370,2615]],"region":{"top_left_x":369,"top_left_y":2573,"width":1047,"height":42},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50ac2d25765b461287bef6140ae0b7ed","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9907509953584395,"confidence_rate":0.9998570557211897},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"533429dc4d054e8285cc63c59f661abb","type":"page_info","conversion_output":false,"text":"811/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-52","page":52,"lines":[{"cnt":[[907,434],[1268,434],[1268,535],[907,535]],"region":{"top_left_x":906,"top_left_y":433,"width":362,"height":102},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f7ec8104228476c84236f41af946728","type":"section_header","conversion_output":false,"children_ids":["7b9f00bcd1874cf3b441786b0125c8db","d44237dc90fe490d934e4d3ae5f315c7"],"text":"","text_display":""},{"cnt":[[988,443],[1188,443],[1188,486],[988,486]],"region":{"top_left_x":988,"top_left_y":442,"width":201,"height":44},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7b9f00bcd1874cf3b441786b0125c8db","type":"text","conversion_output":true,"parent_id":"6f7ec8104228476c84236f41af946728","text":"Appendix F","text_display":"\n\n\\section*{Appendix F","confidence":1,"confidence_rate":1},{"cnt":[[915,483],[1261,483],[1261,526],[915,526]],"region":{"top_left_x":915,"top_left_y":483,"width":347,"height":44},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d44237dc90fe490d934e4d3ae5f315c7","type":"text","conversion_output":true,"parent_id":"6f7ec8104228476c84236f41af946728","text":"Data Handling Rules","text_display":" Data Handling Rules}","confidence":1,"confidence_rate":1},{"cnt":[[432,593],[1729,593],[1729,638],[432,638]],"region":{"top_left_x":431,"top_left_y":592,"width":1299,"height":47},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"07ffff9a236240febbeedf9cf4b6f064","type":"text","conversion_output":true,"text":"The data handling rules will be provided as a separate document to be developed in","text_display":"\n\nThe data handling rules will be provided as a separate document to be developed in","confidence":1,"confidence_rate":1},{"cnt":[[434,645],[1648,645],[1648,690],[434,690]],"region":{"top_left_x":433,"top_left_y":644,"width":1215,"height":46},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c323f9f376e34b3c9626e2918073e8b0","type":"text","conversion_output":true,"text":"conjunction with any dry runs and finalized before database lock for the interim","text_display":" conjunction with any dry runs and finalized before database lock for the interim","confidence":1,"confidence_rate":1},{"cnt":[[434,696],[1128,696],[1128,741],[434,741]],"region":{"top_left_x":433,"top_left_y":696,"width":695,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"06c478bcce144a73894e61ab031edf30","type":"text","conversion_output":true,"text":"analysis and separately for the final analysis.","text_display":" analysis and separately for the final analysis.","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1205,2333],[1205,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":773,"height":37},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d928a29239c41298b38b650b1f4f971","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2404],[434,2404]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":38},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0f8d810021a84d55bc1a570a526a8d86","type":"page_info","conversion_output":false,"text":"51/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2404],[1044,2404]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":38},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d8ba2a241764e9ea7ff70897af328e1","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9e170ed268248779997e2136ce47b91","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.992689836657973,"confidence_rate":0.999887129239324},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f23d1cfc38b4927b939cb4c4075d3fe","type":"page_info","conversion_output":false,"text":"812/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-53","page":53,"lines":[{"cnt":[[975,436],[1195,436],[1195,488],[975,488]],"region":{"top_left_x":975,"top_left_y":436,"width":220,"height":52},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4aa6f94eb23a4cb0b1560417fc68970a","type":"section_header","conversion_output":false,"children_ids":["4da80359a43d490ba25ad20ab970838b"],"text":"","text_display":""},{"cnt":[[984,443],[1190,443],[1190,483],[984,483]],"region":{"top_left_x":983,"top_left_y":442,"width":208,"height":42},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4da80359a43d490ba25ad20ab970838b","type":"text","conversion_output":true,"parent_id":"4aa6f94eb23a4cb0b1560417fc68970a","text":"Appendix G","text_display":"\n\n\\section*{Appendix G}","confidence":1,"confidence_rate":1},{"cnt":[[713,475],[1463,475],[1463,535],[713,535]],"region":{"top_left_x":713,"top_left_y":474,"width":751,"height":61},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95614a7050dc48b1a6a4b1e2d914a989","type":"section_header","conversion_output":false,"children_ids":["33ee1751949744aaaccd8c81c591984c"],"text":"","text_display":""},{"cnt":[[722,483],[1454,483],[1454,526],[722,526]],"region":{"top_left_x":721,"top_left_y":483,"width":734,"height":44},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"33ee1751949744aaaccd8c81c591984c","type":"text","conversion_output":true,"parent_id":"95614a7050dc48b1a6a4b1e2d914a989","text":"Programming Codes for Statistical Analysis","text_display":"\n\n\\section*{Programming Codes for Statistical Analysis}","confidence":1,"confidence_rate":1},{"cnt":[[425,584],[1119,584],[1119,642],[425,642]],"region":{"top_left_x":425,"top_left_y":584,"width":695,"height":59},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"074744477b634e07b884d1a346317104","type":"section_header","conversion_output":false,"children_ids":["40f431b8c447459aa83304e3e86c14c3"],"text":"","text_display":""},{"cnt":[[434,591],[1115,591],[1115,638],[434,638]],"region":{"top_left_x":433,"top_left_y":590,"width":683,"height":49},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40f431b8c447459aa83304e3e86c14c3","type":"text","conversion_output":true,"parent_id":"074744477b634e07b884d1a346317104","text":"Calculation of the EQ-5D summary index","text_display":"\n\n\\section*{Calculation of the EQ-5D summary index}","confidence":1,"confidence_rate":1},{"cnt":[[421,664],[1629,664],[1629,2185],[421,2185]],"region":{"top_left_x":421,"top_left_y":663,"width":1208,"height":1522},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8e462f750cf44af2999b228dca9935f9","type":"diagram","conversion_output":false,"children_ids":["685ae649c2194453b5302384bfbe5f1a","968d7d262e7240d089c8f9573a20a2f2","7c7028255fae41a691b5bdb3040f37ed","d42af575d56e423a9db6f2db0ed109ce","859165d915654d5f9477d9e6ca55ab10","c76b4067e2184f07b65225b882dfbfad","97a82a5c4dc94b47b2fae7b55f1cfccf","c5d7ac5bcb2c44328f6cd9d9c9993f16","3a65d7829bce48d3bf51d5d53a850f89","8f6a77659c094877962d6cdd9eaa3eb5","116ca23188d94558a633d4c2d5c1056b","9a4f5d9f49ea4cd88d8c4f23318c924b","8b0e63d773744861bc9735ea9b6e6588","f43a0d42af374ea5990f4925d57cefe0","6ccb490f04724c9490f2f64b730b71f6","e3ebcb4174ed402a934843ec89b9dbd2","0a90248f00b448d4a2b5d8695de2e9de","b634f13d02824f02a09a9aaaee4bfee8","761d997487864d0f9d31fa749bb2cca7","e07d8d309870415db95d83b37b53560d","8b70db0dd3b54681babe7ad89d5d9246","819bd53dab6f409d823a20510e2a3ba8","3fb6718272d9418b9e84099fcfd4bcb7","239aac87b29d429f929916a7ed049135","07d14f8d00754853bc73c1b527a438a9","8bf47ae88a774cc29d9c1fc861a2d2ba","dc0895db853c4743b826d817b461a45f","b80add2aa105428c8df7da89154296ce","ff7adce82f094d368d8fa7c6127b3b6d","3d603cf44a5549989c9773b6d422105a","7c447569306d4af6a7ceff14756f9036","72889af6e4cd4d4da1387396bf2b43eb","4ca5dda39a7741dfb5a8aef829d6619b","7b6064b7977a4ee68bf56d2b2686a77d","6368f7a17a8548e7b5575444d5147199","4432f6ca307c4881bc82f1e47320e293","8c99ffea0f9d46699b3551c2cabbfc77","7f7e76cc3e244616aeda837a47d16916","0864c0708f824a428c343c8579248f4c","11954c1d50b44b8086c28398d90a906d"],"text":"","text_display":"","subtype":"algorithm"},{"cnt":[[434,670],[1287,670],[1287,703],[434,703]],"region":{"top_left_x":433,"top_left_y":670,"width":854,"height":33},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"685ae649c2194453b5302384bfbe5f1a","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"data LIBNAME.NEWDATANAME ; set LIBNAME.DATANAME ;","text_display":"\n```\ndata LIBNAME.NEWDATANAME ; set LIBNAME.DATANAME ;","confidence":1,"confidence_rate":1},{"cnt":[[434,735],[1620,735],[1620,769],[434,769]],"region":{"top_left_x":433,"top_left_y":734,"width":1187,"height":36},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"968d7d262e7240d089c8f9573a20a2f2","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"/* Generate Dummy Variables for Levels 2 and 3 of Five Dimensions */","text_display":"\n/* Generate Dummy Variables for Levels 2 and 3 of Five Dimensions */","confidence":1,"confidence_rate":1},{"cnt":[[434,769],[698,769],[698,801],[434,801]],"region":{"top_left_x":433,"top_left_y":769,"width":266,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7c7028255fae41a691b5bdb3040f37ed","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"m1 =0 ; m2 =0 ;","text_display":"\nm1 =0 ; m2 =0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,799],[696,799],[696,831],[434,831]],"region":{"top_left_x":433,"top_left_y":799,"width":264,"height":33},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d42af575d56e423a9db6f2db0ed109ce","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"s1 =0 ; s2 =0 ;","text_display":"\ns1 =0 ; s2 =0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,834],[698,834],[698,866],[434,866]],"region":{"top_left_x":433,"top_left_y":833,"width":266,"height":33},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"859165d915654d5f9477d9e6ca55ab10","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"u1 =0 ; u2 =0 ;","text_display":"\nu1 =0 ; u2 =0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,868],[698,868],[698,900],[434,900]],"region":{"top_left_x":433,"top_left_y":867,"width":266,"height":34},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c76b4067e2184f07b65225b882dfbfad","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"p1 =0 ; p2 =0 ;","text_display":"\np1 =0 ; p2 =0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,898],[698,898],[698,935],[434,935]],"region":{"top_left_x":433,"top_left_y":898,"width":266,"height":37},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"97a82a5c4dc94b47b2fae7b55f1cfccf","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"a1 =0 ; a2 =0 ;","text_display":"\na1 =0 ; a2 =0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,962],[941,962],[941,999],[434,999]],"region":{"top_left_x":433,"top_left_y":962,"width":509,"height":38},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"c5d7ac5bcb2c44328f6cd9d9c9993f16","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if mobility = 2 then m1 = 1 ;","text_display":"\nif mobility = 2 then m1 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,997],[943,997],[943,1033],[434,1033]],"region":{"top_left_x":433,"top_left_y":996,"width":511,"height":38},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3a65d7829bce48d3bf51d5d53a850f89","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if mobility = 3 then m2 = 1 ;","text_display":"\nif mobility = 3 then m2 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1027],[941,1027],[941,1063],[434,1063]],"region":{"top_left_x":433,"top_left_y":1026,"width":509,"height":38},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8f6a77659c094877962d6cdd9eaa3eb5","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if selfcare = 2 then s1 = 1 ;","text_display":"\nif selfcare = 2 then s1 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1061],[941,1061],[941,1098],[434,1098]],"region":{"top_left_x":433,"top_left_y":1061,"width":509,"height":37},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"116ca23188d94558a633d4c2d5c1056b","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if selfcare = 3 then s2 = 1 ;","text_display":"\nif selfcare = 3 then s2 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1096],[941,1096],[941,1132],[434,1132]],"region":{"top_left_x":433,"top_left_y":1095,"width":509,"height":38},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9a4f5d9f49ea4cd88d8c4f23318c924b","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if activity = 2 then u1 = 1 ;","text_display":"\nif activity = 2 then u1 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1128],[941,1128],[941,1162],[434,1162]],"region":{"top_left_x":433,"top_left_y":1127,"width":509,"height":36},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8b0e63d773744861bc9735ea9b6e6588","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if activity = 3 then u2 = 1 ;","text_display":"\nif activity = 3 then u2 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1160],[870,1160],[870,1197],[434,1197]],"region":{"top_left_x":433,"top_left_y":1160,"width":438,"height":37},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f43a0d42af374ea5990f4925d57cefe0","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if pain = 2 then p1 = 1 ;","text_display":"\nif pain = 2 then p1 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1195],[870,1195],[870,1231],[434,1231]],"region":{"top_left_x":433,"top_left_y":1194,"width":438,"height":38},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6ccb490f04724c9490f2f64b730b71f6","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if pain = 3 then p2 = 1 ;","text_display":"\nif pain = 3 then p2 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1225],[922,1225],[922,1261],[434,1261]],"region":{"top_left_x":433,"top_left_y":1224,"width":489,"height":38},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e3ebcb4174ed402a934843ec89b9dbd2","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if anxiety = 2 then a1 = 1 ;","text_display":"\nif anxiety = 2 then a1 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1259],[922,1259],[922,1296],[434,1296]],"region":{"top_left_x":433,"top_left_y":1258,"width":489,"height":38},"line":24,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0a90248f00b448d4a2b5d8695de2e9de","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if anxiety = 3 then a2 = 1 ;","text_display":"\nif anxiety = 3 then a2 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1323],[1571,1323],[1571,1360],[434,1360]],"region":{"top_left_x":433,"top_left_y":1323,"width":1138,"height":37},"line":25,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b634f13d02824f02a09a9aaaee4bfee8","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"/* Generate Interaction Terms (I2, I2-squared, I3, I3-squared) */","text_display":"\n/* Generate Interaction Terms (I2, I2-squared, I3, I3-squared) */","confidence":1,"confidence_rate":1},{"cnt":[[434,1358],[578,1358],[578,1394],[434,1394]],"region":{"top_left_x":433,"top_left_y":1357,"width":145,"height":38},"line":26,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"761d997487864d0f9d31fa749bb2cca7","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"m0 = 0 ;","text_display":"\nm0 = 0 ;","confidence":0.99755859375,"confidence_rate":0.9997778072937495},{"cnt":[[434,1388],[578,1388],[578,1424],[434,1424]],"region":{"top_left_x":433,"top_left_y":1387,"width":145,"height":38},"line":27,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e07d8d309870415db95d83b37b53560d","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"s0 = 0 ;","text_display":"\ns0 = 0 ;","confidence":0.92431640625,"confidence_rate":0.992870912014137},{"cnt":[[434,1422],[578,1422],[578,1457],[434,1457]],"region":{"top_left_x":433,"top_left_y":1422,"width":145,"height":35},"line":28,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8b70db0dd3b54681babe7ad89d5d9246","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"u0 = 0 ;","text_display":"\nu0 = 0 ;","confidence":0.99755859375,"confidence_rate":0.9997778072937495},{"cnt":[[434,1457],[578,1457],[578,1493],[434,1493]],"region":{"top_left_x":433,"top_left_y":1456,"width":145,"height":38},"line":29,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"819bd53dab6f409d823a20510e2a3ba8","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"p0 = 0 ;","text_display":"\np0 = 0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1489],[578,1489],[578,1523],[434,1523]],"region":{"top_left_x":433,"top_left_y":1488,"width":145,"height":36},"line":30,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3fb6718272d9418b9e84099fcfd4bcb7","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"a0 = 0 ;","text_display":"\na0 = 0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1551],[1027,1551],[1027,1588],[434,1588]],"region":{"top_left_x":433,"top_left_y":1551,"width":594,"height":37},"line":31,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"239aac87b29d429f929916a7ed049135","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if m1 = 0 and m2 = 0 then m0 = 1 ;","text_display":"\nif m1 = 0 and m2 = 0 then m0 = 1 ;","confidence":0.9897651672363281,"confidence_rate":0.9997219962501301},{"cnt":[[434,1586],[1029,1586],[1029,1622],[434,1622]],"region":{"top_left_x":433,"top_left_y":1585,"width":597,"height":38},"line":32,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"07d14f8d00754853bc73c1b527a438a9","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if s1 = 0 and s2 = 0 then s0 = 1 ;","text_display":"\nif s1 = 0 and s2 = 0 then s0 = 1 ;","confidence":0.99951171875,"confidence_rate":0.9999868000736574},{"cnt":[[434,1620],[1027,1620],[1027,1652],[434,1652]],"region":{"top_left_x":433,"top_left_y":1619,"width":594,"height":34},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8bf47ae88a774cc29d9c1fc861a2d2ba","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if u1 = 0 and u2 = 0 then u0 = 1 ;","text_display":"\nif u1 = 0 and u2 = 0 then u0 = 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1650],[1027,1650],[1027,1687],[434,1687]],"region":{"top_left_x":433,"top_left_y":1650,"width":594,"height":37},"line":34,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"dc0895db853c4743b826d817b461a45f","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if p1 = 0 and p2 = 0 then p0 = 1 ;","text_display":"\nif p1 = 0 and p2 = 0 then p0 = 1 ;","confidence":0.9970703125,"confidence_rate":0.9999207061862236},{"cnt":[[434,1684],[1029,1684],[1029,1721],[434,1721]],"region":{"top_left_x":433,"top_left_y":1684,"width":597,"height":37},"line":35,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b80add2aa105428c8df7da89154296ce","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if a1 = 0 and a2 = 0 then a0 = 1 ;","text_display":"\nif a1 = 0 and a2 = 0 then a0 = 1 ;","confidence":0.9848773445701227,"confidence_rate":0.9995882423942843},{"cnt":[[434,1749],[941,1749],[941,1790],[434,1790]],"region":{"top_left_x":433,"top_left_y":1748,"width":509,"height":42},"line":36,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ff7adce82f094d368d8fa7c6127b3b6d","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i2 = m1 + s1 + u1 + p1 + a1 ;","text_display":"\ni2 = m1 + s1 + u1 + p1 + a1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1783],[664,1783],[664,1820],[434,1820]],"region":{"top_left_x":433,"top_left_y":1783,"width":231,"height":37},"line":37,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3d603cf44a5549989c9773b6d422105a","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i2 = i2 - 1 ;","text_display":"\ni2 = i2 - 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1813],[801,1813],[801,1850],[434,1850]],"region":{"top_left_x":433,"top_left_y":1813,"width":369,"height":37},"line":38,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7c447569306d4af6a7ceff14756f9036","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if i2<0 then i2 = 0 ;","text_display":"\nif i2<0 then i2 = 0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1848],[664,1848],[664,1884],[434,1884]],"region":{"top_left_x":433,"top_left_y":1847,"width":231,"height":38},"line":39,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"72889af6e4cd4d4da1387396bf2b43eb","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i22 = i2*i2 ;","text_display":"\ni22 = i2*i2 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1882],[939,1882],[939,1919],[434,1919]],"region":{"top_left_x":433,"top_left_y":1882,"width":506,"height":37},"line":40,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4ca5dda39a7741dfb5a8aef829d6619b","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i3 = m2 + s2 + u2 + p2 + a2 ;","text_display":"\ni3 = m2 + s2 + u2 + p2 + a2 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1914],[664,1914],[664,1949],[434,1949]],"region":{"top_left_x":433,"top_left_y":1914,"width":231,"height":35},"line":41,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7b6064b7977a4ee68bf56d2b2686a77d","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i3 = i3 - 1 ;","text_display":"\ni3 = i3 - 1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1946],[801,1946],[801,1983],[434,1983]],"region":{"top_left_x":433,"top_left_y":1946,"width":369,"height":38},"line":42,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6368f7a17a8548e7b5575444d5147199","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if i3<0 then i3 = 0 ;","text_display":"\nif i3<0 then i3 = 0 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,1981],[664,1981],[664,2017],[434,2017]],"region":{"top_left_x":433,"top_left_y":1980,"width":231,"height":38},"line":43,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4432f6ca307c4881bc82f1e47320e293","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i32 = i3*i3 ;","text_display":"\ni32 = i3*i3 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,2045],[823,2045],[823,2082],[434,2082]],"region":{"top_left_x":433,"top_left_y":2045,"width":390,"height":37},"line":44,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"8c99ffea0f9d46699b3551c2cabbfc77","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"/* Generate D1 Term */","text_display":"\n/* Generate D1 Term */","confidence":1,"confidence_rate":1},{"cnt":[[434,2080],[939,2080],[939,2116],[434,2116]],"region":{"top_left_x":433,"top_left_y":2079,"width":506,"height":38},"line":45,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7f7e76cc3e244616aeda837a47d16916","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"i1 = m0 + s0 + u0 + p0 + a0 ;","text_display":"\ni1 = m0 + s0 + u0 + p0 + a0 ;","confidence":0.7127058506011963,"confidence_rate":0.9894718599670395},{"cnt":[[434,2110],[664,2110],[664,2146],[434,2146]],"region":{"top_left_x":433,"top_left_y":2109,"width":231,"height":38},"line":46,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0864c0708f824a428c343c8579248f4c","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"d1 = 4 - i1 ;","text_display":"\nd1 = 4 - i1 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,2144],[801,2144],[801,2176],[434,2176]],"region":{"top_left_x":433,"top_left_y":2144,"width":369,"height":33},"line":47,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"11954c1d50b44b8086c28398d90a906d","type":"code","conversion_output":true,"parent_id":"8e462f750cf44af2999b228dca9935f9","text":"if d1<0 then d1 = 0 ;","text_display":"\nif d1<0 then d1 = 0 ;\n```\n","confidence":0.9990234375,"confidence_rate":0.999959290843314},{"cnt":[[434,2368],[1201,2368],[1201,2408],[434,2408]],"region":{"top_left_x":433,"top_left_y":2367,"width":768,"height":42},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b34b10e10bca469b8df16ce962b1095e","type":"text","conversion_output":true,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"\n\nStatistical Analysis Plan: Alteplase-Genentech USMA","confidence":1,"confidence_rate":1},{"cnt":[[434,2402],[604,2402],[604,2438],[434,2438]],"region":{"top_left_x":433,"top_left_y":2401,"width":171,"height":38},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6f7e2d4466854832a7b12d139f41c020","type":"text","conversion_output":true,"text":"52/ML29093","text_display":"\n52/ML29093","confidence":1,"confidence_rate":1},{"cnt":[[1044,2402],[1184,2402],[1184,2438],[1044,2438]],"region":{"top_left_x":1044,"top_left_y":2401,"width":140,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2c7aa832c384454b8e27c8ac914bf0e","type":"text","conversion_output":true,"text":"5/17/2017","text_display":"\n5/17/2017","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"940de5b97e0a4c4c802da602364646a2","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9980480668600649,"confidence_rate":0.9999699413649383},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f5c405063ef460f94cc1c4ac5348ffc","type":"page_info","conversion_output":false,"text":"813/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-54","page":54,"lines":[{"cnt":[[430,434],[1659,434],[1659,932],[430,932]],"region":{"top_left_x":429,"top_left_y":433,"width":1230,"height":500},"line":1,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f7ff4c9c99d84c02801811018d8497ba","type":"diagram","conversion_output":false,"children_ids":["1114e4f1f14f43b09f198a183fc72b07","ce763a990f004a3eb084a00ef6a4ce58","d6106e7a32e5450fbe3dc7fd603aeca9","e2e49f063fef4e0e9e340a11f0719d87","d9c320f209d242c6ac764f433ea32380","047126fc45cb4d7cb3f9ac37df7d3d48","638c35f6514f4867b19cd83e88b62e55","4559249a27604771aeffcb167aaedec8","ae40047ca0d443d48cce2e088f3b7783","7a845430fa3745f4a4553c5e85d984b3","932019e3416a4c3e953dbaf3501767e5","935da0f99097453999352c2d1e2c9509"],"text":"","text_display":"","subtype":"algorithm"},{"cnt":[[434,438],[960,438],[960,471],[434,471]],"region":{"top_left_x":433,"top_left_y":438,"width":528,"height":33},"line":2,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1114e4f1f14f43b09f198a183fc72b07","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"/* Generate Raw Index Score */","text_display":"\n```\n/* Generate Raw Index Score */","confidence":1,"confidence_rate":1},{"cnt":[[434,473],[1586,473],[1586,505],[434,505]],"region":{"top_left_x":433,"top_left_y":472,"width":1153,"height":33},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ce763a990f004a3eb084a00ef6a4ce58","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"pred = .146016*m1 + .557685*m2 + .1753425*s1 + .4711896*s2 +","text_display":"\npred = .146016*m1 + .557685*m2 + .1753425*s1 + .4711896*s2 +","confidence":0.99951171875,"confidence_rate":0.9999922476411908},{"cnt":[[578,507],[1586,507],[1586,539],[578,539]],"region":{"top_left_x":577,"top_left_y":507,"width":1009,"height":33},"line":4,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d6106e7a32e5450fbe3dc7fd603aeca9","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":".1397295*u1 + .3742594*u2 + .1728907*p1 + .5371011*p2 +","text_display":"\n            .1397295*u1 + .3742594*u2 + .1728907*p1 + .5371011*p2 +","confidence":1,"confidence_rate":1},{"cnt":[[578,537],[1583,537],[1583,569],[578,569]],"region":{"top_left_x":577,"top_left_y":537,"width":1007,"height":33},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"e2e49f063fef4e0e9e340a11f0719d87","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":".156223*a1 + .4501876*a2 + -.1395949*d1 + .0106868*i22 +","text_display":"\n            .156223*a1 + .4501876*a2 + -.1395949*d1 + .0106868*i22 +","confidence":1,"confidence_rate":1},{"cnt":[[559,569],[1079,569],[1079,604],[559,604]],"region":{"top_left_x":558,"top_left_y":569,"width":521,"height":35},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d9c320f209d242c6ac764f433ea32380","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"-.1215579*i3 + -.0147963*i32 ;","text_display":"\n        -.1215579*i3 + -.0147963*i32 ;","confidence":1,"confidence_rate":1},{"cnt":[[434,636],[801,636],[801,668],[434,668]],"region":{"top_left_x":433,"top_left_y":635,"width":369,"height":34},"line":7,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"047126fc45cb4d7cb3f9ac37df7d3d48","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"EQ_index = 1 - pred ;","text_display":"\nEQ_index = 1 - pred ;","confidence":1,"confidence_rate":1},{"cnt":[[434,666],[1654,666],[1654,703],[434,703]],"region":{"top_left_x":433,"top_left_y":666,"width":1222,"height":37},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"638c35f6514f4867b19cd83e88b62e55","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"if (mobility = .) or (selfcare = .) or (activity = .) or (pain = .) or","text_display":"\nif (mobility = .) or (selfcare = .) or (activity = .) or (pain = .) or","confidence":1,"confidence_rate":1},{"cnt":[[494,700],[1059,700],[1059,737],[494,737]],"region":{"top_left_x":494,"top_left_y":700,"width":566,"height":37},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4559249a27604771aeffcb167aaedec8","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"(anxiety = .) then EQ_index = . ;","text_display":"\n    (anxiety = .) then EQ_index = . ;","confidence":1,"confidence_rate":1},{"cnt":[[434,765],[1154,765],[1154,801],[434,801]],"region":{"top_left_x":433,"top_left_y":764,"width":721,"height":38},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ae40047ca0d443d48cce2e088f3b7783","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"/* Drop Variables Generated by Program */","text_display":"\n/* Drop Variables Generated by Program */","confidence":1,"confidence_rate":1},{"cnt":[[434,799],[1635,799],[1635,831],[434,831]],"region":{"top_left_x":433,"top_left_y":799,"width":1202,"height":33},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"7a845430fa3745f4a4553c5e85d984b3","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"drop m1 m2 s1 s2 u1 u2 p1 p2 a1 a2 m0 s0 u0 p0 a0 i1 i2 i22 i3 i32 d1","text_display":"\ndrop m1 m2 s1 s2 u1 u2 p1 p2 a1 a2 m0 s0 u0 p0 a0 i1 i2 i22 i3 i32 d1","confidence":1,"confidence_rate":1},{"cnt":[[434,834],[539,834],[539,866],[434,866]],"region":{"top_left_x":433,"top_left_y":833,"width":107,"height":33},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"932019e3416a4c3e953dbaf3501767e5","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"pred ;","text_display":"\npred ;","confidence":1,"confidence_rate":1},{"cnt":[[434,902],[524,902],[524,932],[434,932]],"region":{"top_left_x":433,"top_left_y":902,"width":92,"height":31},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"935da0f99097453999352c2d1e2c9509","type":"code","conversion_output":true,"parent_id":"f7ff4c9c99d84c02801811018d8497ba","text":"run ;","text_display":"\nrun ;\n```\n","confidence":1,"confidence_rate":1},{"cnt":[[430,975],[1302,975],[1302,1027],[430,1027]],"region":{"top_left_x":429,"top_left_y":975,"width":873,"height":52},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"da82fe8b5da04cc9bd701ac43b403c7c","type":"section_header","conversion_output":false,"children_ids":["ca7509d61a6d495294199ac95f9391c9"],"text":"","text_display":""},{"cnt":[[434,980],[1298,980],[1298,1023],[434,1023]],"region":{"top_left_x":433,"top_left_y":979,"width":865,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ca7509d61a6d495294199ac95f9391c9","type":"text","conversion_output":true,"parent_id":"da82fe8b5da04cc9bd701ac43b403c7c","text":"Ordinary Least Squares with Robust Standard Error","text_display":"\n\n\\section*{Ordinary Least Squares with Robust Standard Error}","confidence":1,"confidence_rate":1},{"cnt":[[430,1055],[1326,1055],[1326,1158],[430,1158]],"region":{"top_left_x":429,"top_left_y":1054,"width":897,"height":105},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"426fe2e214064701a79d3bfac96eabcd","type":"diagram","conversion_output":false,"children_ids":["38c90161cc0346299fbd353fe1a959f7","a124b883a355414e817d5ca34f45aa73","1ecbd20a809e4cdebcc6e5e7e9b67e54"],"text":"","text_display":"","subtype":"algorithm"},{"cnt":[[434,1061],[746,1061],[746,1091],[434,1091]],"region":{"top_left_x":433,"top_left_y":1061,"width":313,"height":31},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"38c90161cc0346299fbd353fe1a959f7","type":"code","conversion_output":true,"parent_id":"426fe2e214064701a79d3bfac96eabcd","text":"proc reg data=mrs;","text_display":"\n```\nproc reg data=mrs;","confidence":1,"confidence_rate":1},{"cnt":[[486,1091],[1319,1091],[1319,1124],[486,1124]],"region":{"top_left_x":485,"top_left_y":1091,"width":835,"height":33},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a124b883a355414e817d5ca34f45aa73","type":"code","conversion_output":true,"parent_id":"426fe2e214064701a79d3bfac96eabcd","text":"model mrs = trt age ott nihss / hcc hccmethod=0;","text_display":"\n    model mrs = trt age ott nihss / hcc hccmethod=0;","confidence":1,"confidence_rate":1},{"cnt":[[434,1126],[507,1126],[507,1156],[434,1156]],"region":{"top_left_x":433,"top_left_y":1125,"width":75,"height":31},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1ecbd20a809e4cdebcc6e5e7e9b67e54","type":"code","conversion_output":true,"parent_id":"426fe2e214064701a79d3bfac96eabcd","text":"run;","text_display":"\nrun;\n```\n","confidence":1,"confidence_rate":1},{"cnt":[[434,2333],[1201,2333],[1201,2370],[434,2370]],"region":{"top_left_x":433,"top_left_y":2333,"width":768,"height":37},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5dad02e4f108440aa493aef882d08587","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[434,2368],[604,2368],[604,2400],[434,2400]],"region":{"top_left_x":433,"top_left_y":2367,"width":171,"height":33},"line":21,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"4d0d1d7734484703b8910856b5d4e1ff","type":"page_info","conversion_output":false,"text":"53/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1044,2368],[1184,2368],[1184,2400],[1044,2400]],"region":{"top_left_x":1044,"top_left_y":2367,"width":140,"height":33},"line":22,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ab6bb1a591a547e9a7ff75a337fcc71f","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1420,2574],[1420,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1052,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c1da1dda60254de19bbbd528b883e203","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9922027464535284,"confidence_rate":0.9998795793884556},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"98ffad287d9c4ad9a6ca9421e8489e98","type":"page_info","conversion_output":false,"text":"814/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-55","page":55,"lines":[{"cnt":[[688,524],[1566,524],[1566,578],[688,578]],"region":{"top_left_x":687,"top_left_y":524,"width":880,"height":54},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b886d0298be446bb8511b8cb4954feec","type":"section_header","conversion_output":false,"children_ids":["b693d31d93034c30b6f43c2de1190dac"],"text":"","text_display":""},{"cnt":[[692,529],[1562,529],[1562,574],[692,574]],"region":{"top_left_x":691,"top_left_y":528,"width":871,"height":46},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b693d31d93034c30b6f43c2de1190dac","type":"text","conversion_output":true,"parent_id":"b886d0298be446bb8511b8cb4954feec","text":"Data Analysis Plan (DAP) Module 1 Initial Sign-Off","text_display":"\n\n\\section*{Data Analysis Plan (DAP) Module 1 Initial Sign-Off}","confidence":1,"confidence_rate":1},{"cnt":[[541,632],[1708,632],[1708,840],[541,840]],"region":{"top_left_x":541,"top_left_y":631,"width":1168,"height":210},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b9de34bc59c4f4ea06a5eb55bca78e4","type":"table","conversion_output":true,"text":"\\begin{tabular}{|l|l|l|}\n\\hline Study title: & \\multicolumn{2}{|l|}{\\begin{tabular}{l} \nA PHASE IIIB, DOUBLE-BLIND, MULTICENTER STUDY TO EVALUATE \\\\\nTHE EFFICACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH \\\\\nMILD STROKE (RAPIDLY IMPROVING SYMPTOMS AND MINOR \\\\\nNEUROLOGIC DEFICITS [PRISMS])\n\\end{tabular}} \\\\\n\\hline Protocol \\#: & ML29093 & DAP Version: \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline Study title: & \\multicolumn{2}{|l|}{\\begin{tabular}{l} \nA PHASE IIIB, DOUBLE-BLIND, MULTICENTER STUDY TO EVALUATE \\\\\nTHE EFFICACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH \\\\\nMILD STROKE (RAPIDLY IMPROVING SYMPTOMS AND MINOR \\\\\nNEUROLOGIC DEFICITS [PRISMS])\n\\end{tabular}} \\\\\n\\hline Protocol \\#: & ML29093 & DAP Version: \\\\\n\\hline\n\\end{tabular}","confidence":0.6037972201041762,"confidence_rate":0.9984583245715903},{"cnt":[[546,864],[660,864],[660,892],[546,892]],"region":{"top_left_x":545,"top_left_y":863,"width":115,"height":29},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f032aaaceb784302892a280ed911cbcd","type":"figure_label","conversion_output":false,"text":"Author:","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[537,885],[1708,885],[1708,1042],[537,1042]],"region":{"top_left_x":537,"top_left_y":885,"width":1172,"height":157},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7fbf7cb100240c9bf40cfde01deefaa","type":"diagram","conversion_output":true,"selected_labels":["f032aaaceb784302892a280ed911cbcd"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Author:}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-55.jpg?height=157&width=1172&top_left_y=885&top_left_x=537}\n\\end{figure}"},{"cnt":[[550,1061],[707,1061],[707,1089],[550,1089]],"region":{"top_left_x":550,"top_left_y":1061,"width":157,"height":29},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d35cac7e995a4bb7a18d61c2d9c4bb81","type":"figure_label","conversion_output":false,"text":"Reviewers:","text_display":"","confidence":0.980573166920812,"confidence_rate":0.9986929872808352},{"cnt":[[520,1085],[1708,1085],[1708,1708],[520,1708]],"region":{"top_left_x":519,"top_left_y":1084,"width":1190,"height":625},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcef1868aad5498d80a5aa2dc731302b","type":"diagram","conversion_output":true,"selected_labels":["d35cac7e995a4bb7a18d61c2d9c4bb81"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Reviewers:}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-55.jpg?height=625&width=1190&top_left_y=1084&top_left_x=519}\n\\end{figure}"},{"cnt":[[554,1729],[554,1692],[1678,1702],[1678,1739]],"region":{"top_left_x":554,"top_left_y":1692,"width":1125,"height":48},"line":8,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"94fa775d815c4b7d937155cc8294754e","type":"text","conversion_output":true,"text":"The Biostatistics approver has ensured that key team members have been involved, contributed","text_display":"\n\nThe Biostatistics approver has ensured that key team members have been involved, contributed","confidence":0.6480001674149564,"confidence_rate":0.9955371601128665},{"cnt":[[539,1760],[539,1723],[1601,1732],[1601,1768]],"region":{"top_left_x":539,"top_left_y":1723,"width":1062,"height":46},"line":9,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3a2a265618fd436a937db5a47abe2507","type":"text","conversion_output":true,"text":"and reviewed the content of the List of Planned Outputs as described in the DAP Module 2","text_display":" and reviewed the content of the List of Planned Outputs as described in the DAP Module 2","confidence":1,"confidence_rate":1},{"cnt":[[537,1757],[660,1757],[660,1790],[537,1790]],"region":{"top_left_x":537,"top_left_y":1757,"width":123,"height":33},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"64aaf80fa7be4c739f09feeec33ab347","type":"text","conversion_output":true,"text":"guideline.","text_display":" guideline.","confidence":0.99951171875,"confidence_rate":0.9999674404968648},{"cnt":[[511,2207],[511,2169],[1218,2174],[1218,2212]],"region":{"top_left_x":511,"top_left_y":2169,"width":708,"height":44},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5798aeb74b774fe194641cbcf04b2705","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":0.84912109375,"confidence_rate":0.9970836630856551},{"cnt":[[511,2204],[664,2204],[664,2237],[511,2237]],"region":{"top_left_x":511,"top_left_y":2204,"width":153,"height":33},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d023608072624ed6b9513d319f8fefbc","type":"page_info","conversion_output":false,"text":"54/ML29093","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1074,2209],[1201,2209],[1201,2241],[1074,2241]],"region":{"top_left_x":1074,"top_left_y":2208,"width":127,"height":33},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72fec6d1a16848f386fa8f9ff2b19bb7","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca7d4c3b6f20403680f3f17bcd2f978c","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.9878391707316041,"confidence_rate":0.9998117811439283},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"108005d6749b4d6ab5538e1dab695b09","type":"page_info","conversion_output":false,"text":"815/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"fcd9cbfc-1a14-4635-a147-22fb338ffa31-56","page":56,"lines":[{"cnt":[[569,544],[1369,544],[1369,595],[569,595]],"region":{"top_left_x":569,"top_left_y":543,"width":800,"height":53},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f71ed30087ee44dcac96ed4ee1923cbb","type":"section_header","conversion_output":false,"children_ids":["638e295bea844986acff57ae1126f9e6"],"text":"","text_display":""},{"cnt":[[576,550],[1364,550],[1364,591],[576,591]],"region":{"top_left_x":575,"top_left_y":550,"width":790,"height":41},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"638e295bea844986acff57ae1126f9e6","type":"text","conversion_output":true,"parent_id":"f71ed30087ee44dcac96ed4ee1923cbb","text":"Data Analysis Plan (DAP) Module 1 Initial Sign-Off","text_display":"\n\n\\section*{Data Analysis Plan (DAP) Module 1 Initial Sign-Off}","confidence":0.9448529394032334,"confidence_rate":0.9990224439251177},{"cnt":[[428,638],[1508,638],[1508,823],[428,823]],"region":{"top_left_x":427,"top_left_y":638,"width":1082,"height":185},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"373dd95e0ade4c55b5d6bd86fe89dc51","type":"table","conversion_output":true,"children_ids":["6622320f425b4217a2c46f12643d30c9","f71fc35212ba48f283691eb68f062460","64d0c03e1eac4584be1e6a364c73be0c","cc35e2c431ef41fabf125ea84701f840","c5208d91b25643e49bb907a342c056f3","a4ac88c9e14e422e9d73b1c82a68cf9d","3fe8c2a506cf440396194ff2e300835a","f14249c8158a449d8b54980b32a6d633","1d9855dcb8944c3db4a1c22d04c8a2e8","a45a7be3a686410ba85887f0106f8728","6c42028545ce44c38d4f2f8221de9895","9cc52769851343ba88880b545e1abd6b"],"text":"\\begin{tabular}{|l|l|l|l|}\n\\hline Study tite: & \\multicolumn{3}{|c|}{A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)} \\\\\n\\hline Protocol W: & ML20093 & DAP Version: & 1.0 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|}\n\\hline Study tite: & \\multicolumn{3}{|c|}{A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)} \\\\\n\\hline Protocol W: & ML20093 & DAP Version: & 1.0 \\\\\n\\hline\n\\end{tabular}","confidence":0.3640280902948234,"confidence_rate":0.9823203671445574},{"cnt":[[436,638],[594,638],[594,822],[436,822]],"region":{"top_left_x":435,"top_left_y":638,"width":159,"height":185},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6622320f425b4217a2c46f12643d30c9","type":"table_column","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"","text_display":""},{"cnt":[[607,638],[734,638],[734,822],[607,822]],"region":{"top_left_x":606,"top_left_y":638,"width":129,"height":185},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f71fc35212ba48f283691eb68f062460","type":"table_column","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"","text_display":""},{"cnt":[[1005,638],[1196,638],[1196,822],[1005,822]],"region":{"top_left_x":1005,"top_left_y":638,"width":191,"height":185},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"64d0c03e1eac4584be1e6a364c73be0c","type":"table_column","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"","text_display":""},{"cnt":[[1198,638],[1497,638],[1497,822],[1198,822]],"region":{"top_left_x":1197,"top_left_y":638,"width":300,"height":185},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc35e2c431ef41fabf125ea84701f840","type":"table_column","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"","text_display":""},{"cnt":[[427,767],[427,638],[1508,640],[1507,770]],"region":{"top_left_x":426,"top_left_y":637,"width":1082,"height":133},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5208d91b25643e49bb907a342c056f3","type":"table_row","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"","text_display":""},{"cnt":[[427,759],[1505,759],[1505,792],[427,792]],"region":{"top_left_x":427,"top_left_y":759,"width":1079,"height":33},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4ac88c9e14e422e9d73b1c82a68cf9d","type":"table_row","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"","text_display":""},{"cnt":[[446,642],[589,642],[589,679],[446,679]],"region":{"top_left_x":446,"top_left_y":642,"width":144,"height":38},"line":10,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"3fe8c2a506cf440396194ff2e300835a","type":"simple_cell","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"Study tite:","text_display":"Study tite:","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.3640280902948234,"confidence_rate":0.9387953527696677},{"cnt":[[609,642],[1495,642],[1495,768],[609,768]],"region":{"top_left_x":608,"top_left_y":642,"width":887,"height":126},"line":11,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"f14249c8158a449d8b54980b32a6d633","type":"table_spanning_cell","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","children_ids":["580bba2533844aac87ec46525c3307c8"],"text":"","text_display":"A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":3},{"cnt":[[611,644],[1492,644],[1492,766],[611,766]],"region":{"top_left_x":611,"top_left_y":644,"width":882,"height":122},"line":12,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"580bba2533844aac87ec46525c3307c8","type":"complex_cell","conversion_output":false,"parent_id":"f14249c8158a449d8b54980b32a6d633","children_ids":["a2119bdedaf64d35b4a1b1e55bb53316","df662576e1904c55ad357a6bf4088d01","1624dd093e3243f099cdf88b996384f8","a49a420d1d4b4520a0f4171435370ae5"],"text":"A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)","text_display":"A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR NEUROLOGIC DEFICITS (PRISMS)","cell_row":0,"cell_column":1,"cell_row_span":1,"cell_col_span":3,"confidence":0.10465671519325294,"confidence_rate":0.9791691939093072},{"cnt":[[613,644],[1486,644],[1486,679],[613,679]],"region":{"top_left_x":613,"top_left_y":644,"width":873,"height":36},"line":13,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a2119bdedaf64d35b4a1b1e55bb53316","type":"text","conversion_output":false,"parent_id":"580bba2533844aac87ec46525c3307c8","text":"A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE","text_display":"A PHASE HIS, DOUBLE-BLIND, HULTICENTER STUDY TO EVALUATE","confidence":0.18023084118129093,"confidence_rate":0.9723004286319413},{"cnt":[[613,673],[1434,673],[1434,705],[613,705]],"region":{"top_left_x":613,"top_left_y":672,"width":821,"height":34},"line":14,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"df662576e1904c55ad357a6bf4088d01","type":"text","conversion_output":false,"parent_id":"580bba2533844aac87ec46525c3307c8","text":"THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH","text_display":" THE EFFECACY AND SAFETY OF ALTEPLASE IN PATIENTS WITH","confidence":0.8168084079175533,"confidence_rate":0.9965172733199373},{"cnt":[[613,703],[1404,703],[1404,733],[613,733]],"region":{"top_left_x":613,"top_left_y":702,"width":791,"height":32},"line":15,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1624dd093e3243f099cdf88b996384f8","type":"text","conversion_output":false,"parent_id":"580bba2533844aac87ec46525c3307c8","text":"MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR","text_display":" MILLD STROKE SAPIDLY IMPROWING SYMPTOMS AND MINOR","confidence":0.10465671519325294,"confidence_rate":0.9590638885289002},{"cnt":[[613,731],[1055,731],[1055,766],[613,766]],"region":{"top_left_x":613,"top_left_y":731,"width":442,"height":35},"line":16,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a49a420d1d4b4520a0f4171435370ae5","type":"text","conversion_output":false,"parent_id":"580bba2533844aac87ec46525c3307c8","text":"NEUROLOGIC DEFICITS (PRISMS)","text_display":" NEUROLOGIC DEFICITS (PRISMS)","confidence":0.6995808621465089,"confidence_rate":0.9892319138578801},{"cnt":[[440,757],[589,757],[589,790],[440,790]],"region":{"top_left_x":439,"top_left_y":757,"width":151,"height":33},"line":17,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"1d9855dcb8944c3db4a1c22d04c8a2e8","type":"simple_cell","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"Protocol W:","text_display":"Protocol W:","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.8942967366892844,"confidence_rate":0.9930419675706444},{"cnt":[[613,764],[728,764],[728,790],[613,790]],"region":{"top_left_x":613,"top_left_y":763,"width":116,"height":27},"line":18,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a45a7be3a686410ba85887f0106f8728","type":"simple_cell","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"ML20093","text_display":"ML20093","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.82666015625,"confidence_rate":0.9842616950816242},{"cnt":[[1016,764],[1191,764],[1191,792],[1016,792]],"region":{"top_left_x":1016,"top_left_y":763,"width":176,"height":29},"line":19,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"6c42028545ce44c38d4f2f8221de9895","type":"simple_cell","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"DAP Version:","text_display":"DAP Version:","cell_row":1,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":0.9472893074119669,"confidence_rate":0.9968197305338435},{"cnt":[[1207,764],[1252,764],[1252,794],[1207,794]],"region":{"top_left_x":1206,"top_left_y":763,"width":47,"height":31},"line":20,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"9cc52769851343ba88880b545e1abd6b","type":"simple_cell","conversion_output":false,"parent_id":"373dd95e0ade4c55b5d6bd86fe89dc51","text":"1.0","text_display":"1.0","cell_row":1,"cell_column":3,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[438,838],[541,838],[541,870],[438,870]],"region":{"top_left_x":438,"top_left_y":837,"width":104,"height":34},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fa4295b6e5a4c6d8aa4f8c27f3bde16","type":"text","conversion_output":true,"text":"Author:","text_display":"\n\nAuthor:","confidence":0.9858739242190495,"confidence_rate":0.9988151359681379},{"cnt":[[415,864],[1515,864],[1515,1008],[415,1008]],"region":{"top_left_x":414,"top_left_y":863,"width":1101,"height":145},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d43b23dc3d16492ea1151084267c6485","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-56.jpg?height=145&width=1101&top_left_y=863&top_left_x=414)"},{"cnt":[[430,1018],[578,1018],[578,1051],[430,1051]],"region":{"top_left_x":429,"top_left_y":1018,"width":149,"height":33},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7c9c81f36db4950a8d460d53533aaa5","type":"text","conversion_output":true,"text":"Revlewors:","text_display":"\n\nRevlewors:","confidence":0.7812592326961418,"confidence_rate":0.9836781186107827},{"cnt":[[380,1046],[1562,1046],[1562,1635],[380,1635]],"region":{"top_left_x":380,"top_left_y":1046,"width":1182,"height":589},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5dc912ba5c6e4fcdaff1160b47ccab32","type":"diagram","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-56.jpg?height=589&width=1182&top_left_y=1046&top_left_x=380)"},{"cnt":[[395,1626],[1519,1626],[1519,1661],[395,1661]],"region":{"top_left_x":395,"top_left_y":1626,"width":1124,"height":35},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6222bf72ffb4e8f9d8395a517f154d3","type":"text","conversion_output":true,"text":"","text_display":"\n![](https://cdn.mathpix.com/cropped/fcd9cbfc-1a14-4635-a147-22fb338ffa31-56.jpg?height=35&width=1124&top_left_y=1626&top_left_x=395)"},{"cnt":[[395,1659],[1439,1659],[1439,1691],[395,1691]],"region":{"top_left_x":395,"top_left_y":1658,"width":1045,"height":33},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4b0fa379cdd2452ebe7b77d042e50c56","type":"text","conversion_output":true,"text":"and reviewed the content of the List of Planned Outputs as described in the DAP Module 2","text_display":" and reviewed the content of the List of Planned Outputs as described in the DAP Module 2","confidence":0.42107662152730757,"confidence_rate":0.990642529408053},{"cnt":[[395,1687],[511,1687],[511,1721],[395,1721]],"region":{"top_left_x":395,"top_left_y":1686,"width":117,"height":35},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dcfd66b6ee87458fa269d345c69ff0bb","type":"text","conversion_output":true,"text":"guideline.","text_display":" guideline.","confidence":0.9613280864432454,"confidence_rate":0.9973741517738175},{"cnt":[[348,2157],[348,2114],[1068,2118],[1068,2162]],"region":{"top_left_x":347,"top_left_y":2114,"width":721,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5584b47fc2b14370b92454f0f4447885","type":"page_info","conversion_output":false,"text":"Statistical Analysis Plan: Alteplase-Genentech USMA","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[348,2153],[509,2153],[509,2185],[348,2185]],"region":{"top_left_x":348,"top_left_y":2152,"width":162,"height":33},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"846624a1c2f745b79b16da574d072de9","type":"page_info","conversion_output":false,"text":"54ML29093","text_display":"","confidence":0.99462890625,"confidence_rate":0.9996153904146227},{"cnt":[[924,2157],[1051,2157],[1051,2189],[924,2189]],"region":{"top_left_x":923,"top_left_y":2157,"width":128,"height":33},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e53400fe455c485da840b79e69e68c8c","type":"page_info","conversion_output":false,"text":"5/17/2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[370,2574],[1418,2574],[1418,2619],[370,2619]],"region":{"top_left_x":369,"top_left_y":2573,"width":1049,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cf29602901e44199a9a814a91b73ca4","type":"page_info","conversion_output":false,"text":"Abbreviated Clinical Study Report: Alteplase-Genentech, Inc.","text_display":"","confidence":0.989292828598991,"confidence_rate":0.9998343997802431},{"cnt":[[370,2608],[694,2608],[694,2645],[370,2645]],"region":{"top_left_x":369,"top_left_y":2608,"width":325,"height":37},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bd69e2d4df349409013e4a4f1072910","type":"page_info","conversion_output":false,"text":"816/aCSR ML29093","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}
\ No newline at end of file