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Duration in the SOC arm will be determined by the patient's primary medical provider. \\\\\n\\hline Description of Agent or Intervention: & Vancomycin or protocol-approved alternate antibiotic, with duration determined by clinical treatment algorithm vs SOC \\\\\n\\hline Objectives: & \\begin{tabular}{l}\nPrimary: \\\\\n- To demonstrate that the clinical efficacy of algorithm-based treatment of patients with staphylococcal blood stream infection is noninferior to current standard of care. \\\\\n- To evaluate the safety of algorithm-based treatment as an alternative to current standard of care.\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|}\n\\hline Title: & A Multi-Center, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Adult Patients with Blood Stream Infections due to Staphylococci \\\\\n\\hline Phase: & II \\\\\n\\hline Population: & Approximately 500 patients at least 18 years of age who have a blood stream infection with staphylococci \\\\\n\\hline Number of Sites: & Thirteen sites in the United States (US) and one site in Europe \\\\\n\\hline Study Duration: & Six years \\\\\n\\hline Patient Participation Duration: & Duration of treatment varies based on algorithm or standard of care (SOC) and organism identified ( \\(S\\). aureus vs coagulase negative staphylococcus). 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However, it is not reason to withdraw patient when diagnosed after randomization but before the completion of the treatment period for uncomplicated \\(S\\). aureus.\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nComplicated (all other) \\({ }^{ a }\\) \\\\\n28-42 (-/+2) calendar days of treatment - Any of the following: \\\\\n- Positive follow-up blood culture for S. aureus \\\\\n- Persistent fever (Oral temperature \\(\\geq 38.0 C\\) ) for \\(>72\\) hours following initial positive blood culture collection \\\\\n- Echocardiography reveals evidence of endocarditis \\\\\n- Symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\nReminder: Complicated infection is one of the protocol exclusions. However, it is not reason to withdraw patient when diagnosed after randomization but before the completion of the treatment period for uncomplicated \\(S\\). aureus.\n\\end{tabular}","cell_row":1,"cell_column":1,"cell_row_span":1,"cell_col_span":1,"confidence":0.56201171875,"confidence_rate":0.9986844739141604},{"cnt":[[1002,624],[1329,624],[1329,656],[1002,656]],"region":{"top_left_x":1001,"top_left_y":623,"width":328,"height":34},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8529f05d188449d0a81ed4abcb5f85a4","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"Complicated (all other) \\({ }^{ a }\\)","text_display":"Complicated (all other) \\({ }^{ a }\\)","confidence":0.56201171875,"confidence_rate":0.9853334232833185},{"cnt":[[1002,685],[1814,685],[1814,719],[1002,719]],"region":{"top_left_x":1001,"top_left_y":684,"width":813,"height":36},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c9c954220204eeea81e51622d41d88b","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"28-42 (-/+2) calendar days of treatment - Any of the following:","text_display":"\n28-42 (-/+2) calendar days of treatment - Any of the following:","confidence":0.9985356330871582,"confidence_rate":0.9999784496418309},{"cnt":[[1002,741],[1636,741],[1636,776],[1002,776]],"region":{"top_left_x":1001,"top_left_y":740,"width":636,"height":36},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ab7a9b9788a4221ae88d53157d73720","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"- Positive follow-up blood culture for S. aureus","text_display":"\n- Positive follow-up blood culture for S. aureus","confidence":1,"confidence_rate":1},{"cnt":[[1002,776],[1805,776],[1805,808],[1002,808]],"region":{"top_left_x":1001,"top_left_y":775,"width":805,"height":34},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"819d6cbb53ea414e8b14a4a92641354d","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"- Persistent fever (Oral temperature \\(\\geq 38.0 C\\) ) for \\(>72\\) hours","text_display":"\n- Persistent fever (Oral temperature \\(\\geq 38.0 C\\) ) for \\(>72\\) hours","confidence":0.9588894844055176,"confidence_rate":0.9994251043406331},{"cnt":[[1080,810],[1658,810],[1658,843],[1080,843]],"region":{"top_left_x":1079,"top_left_y":810,"width":580,"height":33},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e19d5caefff445a998fd77281f240ae1","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"following initial positive blood culture collection","text_display":" following initial positive blood culture collection","confidence":1,"confidence_rate":1},{"cnt":[[1002,840],[1721,840],[1721,875],[1002,875]],"region":{"top_left_x":1001,"top_left_y":840,"width":720,"height":36},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d0f451a91adc4392934b208a12768548","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"- Echocardiography reveals evidence of endocarditis","text_display":"\n- Echocardiography reveals evidence of endocarditis","confidence":1,"confidence_rate":1},{"cnt":[[1002,875],[1823,875],[1823,908],[1002,908]],"region":{"top_left_x":1001,"top_left_y":875,"width":822,"height":33},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1013418d6a634821b20120bd8b9db707","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"- Symptoms or signs of metastatic infection, such as vertebral","text_display":"\n- Symptoms or signs of metastatic infection, such as vertebral","confidence":1,"confidence_rate":1},{"cnt":[[1076,908],[1849,908],[1849,942],[1076,942]],"region":{"top_left_x":1075,"top_left_y":907,"width":774,"height":36},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"643807b0ad724fc7a41fb5f706772363","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"osteomyelitis, endocarditis, septic thrombophlebitis (superficial","text_display":" osteomyelitis, endocarditis, septic thrombophlebitis (superficial","confidence":1,"confidence_rate":1},{"cnt":[[1076,940],[1528,940],[1528,973],[1076,973]],"region":{"top_left_x":1075,"top_left_y":940,"width":454,"height":33},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bb0f50de98640b4a79a1767d70e37f3","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"septic thrombophlebitis is permitted)","text_display":" septic thrombophlebitis is permitted)","confidence":1,"confidence_rate":1},{"cnt":[[1002,1035],[1825,1035],[1825,1072],[1002,1072]],"region":{"top_left_x":1001,"top_left_y":1035,"width":824,"height":38},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7e0735bb243342c1aae494f596fac46d","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"Reminder: Complicated infection is one of the protocol","text_display":"\nReminder: Complicated infection is one of the protocol","confidence":1,"confidence_rate":1},{"cnt":[[1002,1077],[1853,1077],[1853,1116],[1002,1116]],"region":{"top_left_x":1001,"top_left_y":1076,"width":852,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0ae55976c2574e79bddd16d4a117e281","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"exclusions. However, it is not reason to withdraw patient","text_display":" exclusions. However, it is not reason to withdraw patient","confidence":1,"confidence_rate":1},{"cnt":[[1002,1118],[1771,1118],[1771,1154],[1002,1154]],"region":{"top_left_x":1001,"top_left_y":1117,"width":770,"height":38},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"375dade6f8db4a068251400ddc085c09","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"when diagnosed after randomization but before the","text_display":" when diagnosed after randomization but before the","confidence":1,"confidence_rate":1},{"cnt":[[1002,1159],[1842,1159],[1842,1196],[1002,1196]],"region":{"top_left_x":1001,"top_left_y":1158,"width":842,"height":38},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cb09f4cd33d0404981886c635c98ec8c","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"completion of the treatment period for uncomplicated \\(S\\).","text_display":" completion of the treatment period for uncomplicated \\(S\\).","confidence":0.822265625,"confidence_rate":0.9969469857155382},{"cnt":[[1002,1204],[1119,1204],[1119,1232],[1002,1232]],"region":{"top_left_x":1001,"top_left_y":1204,"width":118,"height":29},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"48be1d2f4da14687954bdb9d9a4bf063","type":"text","conversion_output":false,"parent_id":"ab05157380d644f7988d004972363ce1","text":"aureus.","text_display":" aureus.","confidence":1,"confidence_rate":1},{"cnt":[[245,1317],[1876,1317],[1876,2273],[245,2273]],"region":{"top_left_x":244,"top_left_y":1316,"width":1632,"height":958},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"041da2c23b1b4aa285ad89a192a11019","type":"table","conversion_output":true,"children_ids":["403f3367d7de45eda266bd067cc0f0f3","5d6c7298e63c4f54839ecf63bcc629b2","994236c817694ea7bac9b58fd16c90a4","734e9e4deb564ee3ac9e8afda2e99182","fc117762975e404b9f37d208622c2d99","e0c547f2ea6e4711b7c32fec6a5c6438","a874fa481dc9476294ae9ca439082841","c7070f3398834b6794ee536722f90a1c","878ee057b7f242ee867310ce3a64d799"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|c|}{Coagulase negative staphylococcal Blood Stream Infection} \\\\\n\\hline \\begin{tabular}{l}\nSimple \\\\\n0-3 (+1) calendar days of treatment - All of the following: \\\\\n- Single blood culture positive for coagulase negative staphylococci \\\\\n- No signs or symptoms of local infection \\\\\n- Negative follow up blood culture (drawn 24-168 hours following initial blood culture collection \\\\\n- No symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\n- No indwelling intravascular prosthetic devices (see above)\n\\end{tabular} & \\begin{tabular}{l}\nUncomplicated \\\\\n\\(5(-/+1)\\) calendar days of treatment \\\\\nEITHER: \\\\\n- \\(\\geq 2\\) sets blood cultures positive for coagulase negative staphylococci from samples drawn \\(\\leq 24\\) hours apart (e.g. 23:50 hours Tues. night and 14:00 Wed. afternoon). \\\\\nOr \\\\\n- Single set of blood cultures positive for coagulase negative staphylococci PLUS signs/ symptoms of infection at catheter site (e.g., focal pain, induration, erythema, drainage, etc). \\\\\nPLUS ALL of the following \\\\\n- Removable focus (intravascular catheter) removed, if present, within 5 days of initial blood culture draw. \\\\\n- Negative follow up blood culture (drawn 24 168 hours following initial blood culture collection \\\\\n- No symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\n- No indwelling intravascular prosthetic devices (see above.\n\\end{tabular} & \\begin{tabular}{l}\nComplicated \\\\\n7-28 (-/+2) calendar days of treatment - Any of the following: \\\\\n- \\(\\geq 2\\) sets blood cultures positive for CoNS from samples drawn > 24 hours apart. \\\\\n- Symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted). \\\\\nReminder: Complicated infection is one of the protocol exclusions. However, it is not reason to withdraw patient when diagnosed after randomization but before completion of the treatment period for the baseline clinical classification of bacteremia (i.e. simple or uncomplicated CoNS).\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|}\n\\hline \\multicolumn{3}{|c|}{Coagulase negative staphylococcal Blood Stream Infection} \\\\\n\\hline \\begin{tabular}{l}\nSimple \\\\\n0-3 (+1) calendar days of treatment - All of the following: \\\\\n- Single blood culture positive for coagulase negative staphylococci \\\\\n- No signs or symptoms of local infection \\\\\n- Negative follow up blood culture (drawn 24-168 hours following initial blood culture collection \\\\\n- No symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\n- No indwelling intravascular prosthetic devices (see above)\n\\end{tabular} & \\begin{tabular}{l}\nUncomplicated \\\\\n\\(5(-/+1)\\) calendar days of treatment \\\\\nEITHER: \\\\\n- \\(\\geq 2\\) sets blood cultures positive for coagulase negative staphylococci from samples drawn \\(\\leq 24\\) hours apart (e.g. 23:50 hours Tues. night and 14:00 Wed. afternoon). \\\\\nOr \\\\\n- Single set of blood cultures positive for coagulase negative staphylococci PLUS signs/ symptoms of infection at catheter site (e.g., focal pain, induration, erythema, drainage, etc). \\\\\nPLUS ALL of the following \\\\\n- Removable focus (intravascular catheter) removed, if present, within 5 days of initial blood culture draw. \\\\\n- Negative follow up blood culture (drawn 24 168 hours following initial blood culture collection \\\\\n- No symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\n- No indwelling intravascular prosthetic devices (see above.\n\\end{tabular} & \\begin{tabular}{l}\nComplicated \\\\\n7-28 (-/+2) calendar days of treatment - Any of the following: \\\\\n- \\(\\geq 2\\) sets blood cultures positive for CoNS from samples drawn > 24 hours apart. \\\\\n- Symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted). \\\\\nReminder: Complicated infection is one of the protocol exclusions. However, it is not reason to withdraw patient when diagnosed after randomization but before completion of the treatment period for the baseline clinical classification of bacteremia (i.e. simple or uncomplicated CoNS).\n\\end{tabular} \\\\\n\\hline\n\\end{tabular}","confidence":0.95068359375,"confidence_rate":0.999970514344696},{"cnt":[[257,1316],[653,1316],[653,2273],[257,2273]],"region":{"top_left_x":256,"top_left_y":1316,"width":398,"height":958},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"403f3367d7de45eda266bd067cc0f0f3","type":"table_column","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","text":"","text_display":""},{"cnt":[[662,1316],[1357,1316],[1357,2271],[662,2271]],"region":{"top_left_x":661,"top_left_y":1316,"width":697,"height":955},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5d6c7298e63c4f54839ecf63bcc629b2","type":"table_column","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","text":"","text_display":""},{"cnt":[[1364,1316],[1866,1316],[1866,2273],[1364,2273]],"region":{"top_left_x":1363,"top_left_y":1316,"width":503,"height":958},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"994236c817694ea7bac9b58fd16c90a4","type":"table_column","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","text":"","text_display":""},{"cnt":[[244,1325],[1879,1325],[1879,1374],[244,1374]],"region":{"top_left_x":244,"top_left_y":1324,"width":1635,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"734e9e4deb564ee3ac9e8afda2e99182","type":"table_row","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","text":"","text_display":""},{"cnt":[[244,1372],[1877,1372],[1877,2271],[244,2271]],"region":{"top_left_x":244,"top_left_y":1372,"width":1633,"height":899},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc117762975e404b9f37d208622c2d99","type":"table_row","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","text":"","text_display":""},{"cnt":[[253,1325],[1868,1325],[1868,1374],[253,1374]],"region":{"top_left_x":252,"top_left_y":1324,"width":1617,"height":51},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0c547f2ea6e4711b7c32fec6a5c6438","type":"table_spanning_cell","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","children_ids":["810d4580c589411ba3945da8fe4f9825"],"text":"","text_display":"Coagulase negative staphylococcal Blood Stream Infection","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":3},{"cnt":[[666,1333],[1459,1333],[1459,1370],[666,1370]],"region":{"top_left_x":666,"top_left_y":1333,"width":793,"height":38},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"810d4580c589411ba3945da8fe4f9825","type":"simple_cell","conversion_output":false,"parent_id":"e0c547f2ea6e4711b7c32fec6a5c6438","text":"Coagulase negative staphylococcal Blood Stream Infection","text_display":"Coagulase negative staphylococcal Blood Stream Infection","cell_row":0,"cell_column":0,"cell_row_span":1,"cell_col_span":3,"confidence":1,"confidence_rate":1},{"cnt":[[261,1374],[649,1374],[649,2215],[261,2215]],"region":{"top_left_x":261,"top_left_y":1374,"width":388,"height":841},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a874fa481dc9476294ae9ca439082841","type":"complex_cell","conversion_output":false,"parent_id":"041da2c23b1b4aa285ad89a192a11019","children_ids":["661e75eccb9d4544bf67730288c15f2f","2f8e27bc70514c61a1e83f2f3970caa0","95e1998b64954dcb97cb051412d7ed47","6cf5d096527a4c14b8425464612e69f5","1ece5e8cc9ac4c248fb261d128c05ce6","24a3c5d41b8548ae86c762fbe8cc456e","ed59a94661ff472db2de0f82004256de","6dc4317c945041ff96b0d4393c689742","2ecc104f54b04831bd8560c9f2af52ba","9af4c65b76fd4a2a84323daf649b9e01","d8eea5facd004fd195d5aa0871a97aea","a85d980688c34e37b16b4716668b7cdf","6d2e16696a7344c7be0ae3ccdef59d5f","300dfac4a16f434db89ce5f80c762530","47b15af99e5f4116940a38f54fe3cdf5","e15b1649e8a0465db73f98c73bacc459","5a7d10d0f7904b4494623e7c5b89ea0d","5613b86a345645c295123525045e5eb2","4aec5675b75145779d5299145557c942","2c91cadb8e6c453dac88db52d871bfdd","b80f5475daa1423da8e5aab514b7f57a","90d40fb9708c42fea4dfee1395bf0c83","3337831447a64c999deb1e37973cf45b","7410ce6c9e454de39c1702415c694ca3","42873f71b4bc4c939c8ed27f756c715d"],"text":"\\begin{tabular}{l}\nSimple \\\\\n0-3 (+1) calendar days of treatment - All of the following: \\\\\n- Single blood culture positive for coagulase negative staphylococci \\\\\n- No signs or symptoms of local infection \\\\\n- Negative follow up blood culture (drawn 24-168 hours following initial blood culture collection \\\\\n- No symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\n- No indwelling intravascular prosthetic devices (see above)\n\\end{tabular}","text_display":"\\begin{tabular}{l}\nSimple \\\\\n0-3 (+1) calendar days of treatment - All of the following: \\\\\n- Single blood culture positive for coagulase negative staphylococci \\\\\n- No signs or symptoms of local infection \\\\\n- Negative follow up blood culture (drawn 24-168 hours following initial blood culture collection \\\\\n- No symptoms or signs of metastatic infection, such as vertebral osteomyelitis, endocarditis, septic thrombophlebitis (superficial septic thrombophlebitis is permitted) \\\\\n- No indwelling intravascular prosthetic devices (see above)\n\\end{tabular}","cell_row":1,"cell_column":0,"cell_row_span":1,"cell_col_span":1,"confidence":0.9975595474243164,"confidence_rate":0.9999967420915284},{"cnt":[[266,1379],[367,1379],[367,1413],[266,1413]],"region":{"top_left_x":265,"top_left_y":1378,"width":103,"height":36},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"661e75eccb9d4544bf67730288c15f2f","type":"text","conversion_output":false,"parent_id":"a874fa481dc9476294ae9ca439082841","text":"Simple","text_display":"Simple","confidence":1,"confidence_rate":1},{"cnt":[[266,1416],[601,1416],[601,1452],[266,1452]],"region":{"top_left_x":265,"top_left_y":1415,"width":337,"height":38},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2f8e27bc70514c61a1e83f2f3970caa0","type":"text","conversion_output":false,"parent_id":"a874fa481dc9476294ae9ca439082841","text":"0-3 (+1) calendar days of","text_display":"\n0-3 (+1) calendar days of","confidence":0.9975595474243164,"confidence_rate":0.9999185554723219},{"cnt":[[266,1455],[545,1455],[545,1487],[266,1487]],"region":{"top_left_x":265,"top_left_y":1454,"width":281,"height":34},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95e1998b64954dcb97cb051412d7ed47","type":"text","conversion_output":false,"parent_id":"a874fa481dc9476294ae9ca439082841","text":"treatment - All of the","text_display":" treatment - All of the","confidence":1,"confidence_rate":1},{"cnt":[[266,1491],[406,1491],[406,1526],[266,1526]],"region":{"top_left_x":265,"top_left_y":1491,"width":142,"height":36},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6cf5d096527a4c14b8425464612e69f5","type":"text","conversion_output":false,"parent_id":"a874fa481dc9476294ae9ca439082841","text":"following:","text_display":" 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Simultaneously, the pipeline","confidence":1,"confidence_rate":1},{"cnt":[[245,881],[1652,881],[1652,930],[245,930]],"region":{"top_left_x":244,"top_left_y":880,"width":1409,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6241c6d692af41eb80adecd2fbe277ee","type":"text","conversion_output":true,"text":"of new antibiotics is dwindling just as the clinical need for these novel treatments is","text_display":" of new antibiotics is dwindling just as the clinical need for these novel treatments is","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[245,930],[1863,930],[1863,982],[245,982]],"region":{"top_left_x":244,"top_left_y":930,"width":1619,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1a692a866a545ff9a77e1c10440e269","type":"text","conversion_output":true,"text":"expanding. \\({ }^{1,2}\\) This dual threat of increasing antimicrobial resistance and decreasing numbers of","text_display":" expanding. \\({ }^{1,2}\\) This dual threat of increasing antimicrobial resistance and decreasing numbers of","confidence":1,"confidence_rate":1},{"cnt":[[245,982],[1850,982],[1850,1029],[245,1029]],"region":{"top_left_x":244,"top_left_y":981,"width":1606,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f66b9967acc84ad88ea7ed357c1ae3a2","type":"text","conversion_output":true,"text":"anti-infectives under development underscores the need to identify new strategies to maximize","text_display":" anti-infectives under development underscores the need to identify new strategies to maximize","confidence":1,"confidence_rate":1},{"cnt":[[245,1031],[1848,1031],[1848,1081],[245,1081]],"region":{"top_left_x":244,"top_left_y":1031,"width":1604,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3da64b83b42549f4b75625b9d56517c8","type":"text","conversion_output":true,"text":"the clinical utility of existing antibiotics through more rational utilization of this precious national","text_display":" the clinical utility of existing antibiotics through more rational utilization of this precious national","confidence":1,"confidence_rate":1},{"cnt":[[245,1087],[410,1087],[410,1124],[245,1124]],"region":{"top_left_x":244,"top_left_y":1087,"width":167,"height":37},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb4fa8bb907944f29d5c2f65121edd9d","type":"text","conversion_output":true,"text":"resource.","text_display":" resource.","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1863,1147],[1863,1197],[245,1197]],"region":{"top_left_x":244,"top_left_y":1147,"width":1619,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"988e819de66f4812a1c9b7660d13c33a","type":"text","conversion_output":true,"text":"For more than three decades, vancomycin has been the mainstay antibiotic for the treatment of","text_display":"\n\nFor more than three decades, vancomycin has been the mainstay antibiotic for the treatment of","confidence":1,"confidence_rate":1},{"cnt":[[245,1199],[1740,1199],[1740,1248],[245,1248]],"region":{"top_left_x":244,"top_left_y":1198,"width":1497,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d246b4db6364508b38c6acb2dbe5c05","type":"text","conversion_output":true,"text":"serious infections due to resistant staphylococci. This reliance on vancomycin has led to","text_display":" serious infections due to resistant staphylococci. This reliance on vancomycin has led to","confidence":0.9990234375,"confidence_rate":0.9999896060152111},{"cnt":[[245,1248],[1828,1248],[1828,1300],[245,1300]],"region":{"top_left_x":244,"top_left_y":1248,"width":1585,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e68bad36a6be41288f1f4559821f6334","type":"text","conversion_output":true,"text":"significant overuse. For example, in 1995, over 14,000 kilograms of vancomycin were used in","text_display":" significant overuse. For example, in 1995, over 14,000 kilograms of vancomycin were used in","confidence":0.5845752251334488,"confidence_rate":0.9945917501895798},{"cnt":[[245,1298],[1876,1298],[1876,1347],[245,1347]],"region":{"top_left_x":244,"top_left_y":1297,"width":1632,"height":51},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3efdbe4013cd4173a084c606954c28c1","type":"text","conversion_output":true,"text":"the US and Western Europe alone. \\({ }^{3}\\) This overuse of vancomycin has ultimately contributed to a","text_display":" the US and Western Europe alone. \\({ }^{3}\\) This overuse of vancomycin has ultimately contributed to a","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[245,1349],[1803,1349],[1803,1399],[245,1399]],"region":{"top_left_x":244,"top_left_y":1349,"width":1559,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"574870c6734e49908ce54be4dabe46d4","type":"text","conversion_output":true,"text":"diminished clinical utility of the antibiotic in staphylococci. Several reports have documented","text_display":" diminished clinical utility of the antibiotic in staphylococci. Several reports have documented","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1747,1396],[1747,1448],[245,1448]],"region":{"top_left_x":244,"top_left_y":1396,"width":1503,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff42b7991b6c456882f51d88ba35f562","type":"text","conversion_output":true,"text":"increasing resistance to vancomycin in clinical isolates of \\(S\\). aureus \\({ }^{4,5,6,7 \\text { and coagulase }}\\)","text_display":" increasing resistance to vancomycin in clinical isolates of \\(S\\). aureus \\({ }^{4,5,6,7 \\text { and coagulase }}\\)","confidence":0.15700898605486618,"confidence_rate":0.9833094723739505},{"cnt":[[245,1448],[1652,1448],[1652,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1448,"width":1409,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bab782846a8e4aadb732f05fb6c75bff","type":"text","conversion_output":true,"text":"negative staphylococci \\({ }^{8}, 9,{ }^{10}, 11,{ }^{12},{ }^{13}\\) as well as rising vancomycin minimum inhibitory","text_display":" negative staphylococci \\({ }^{8}, 9,{ }^{10}, 11,{ }^{12},{ }^{13}\\) as well as rising vancomycin minimum inhibitory","confidence":0.3779591660157264,"confidence_rate":0.9920565605042143},{"cnt":[[245,1500],[1708,1500],[1708,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":1465,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8b9e15025d2479d85b99c95da9322a1","type":"text","conversion_output":true,"text":"concentrations (\"MIC creep\") among large surveys of clinical strains of staphylococci \\({ }^{8}\\).","text_display":" concentrations (\"MIC creep\") among large surveys of clinical strains of staphylococci \\({ }^{8}\\).","confidence":0.9985356330871582,"confidence_rate":0.9999859093286404},{"cnt":[[245,1568],[1781,1568],[1781,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1568,"width":1538,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d944240bbb214282b628ae11e9ace605","type":"text","conversion_output":true,"text":"Nowhere is the challenge of vancomycin overuse more pervasive than among hospitalized","text_display":"\n\nNowhere is the challenge of vancomycin overuse more pervasive than among hospitalized","confidence":1,"confidence_rate":1},{"cnt":[[245,1618],[1755,1618],[1755,1665],[245,1665]],"region":{"top_left_x":244,"top_left_y":1617,"width":1512,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4292bd18e6bc484a8ed11ceeacd49942","type":"text","conversion_output":true,"text":"patients with suspected or confirmed blood stream infection. Sepsis is a leading cause of","text_display":" patients with suspected or confirmed blood stream infection. Sepsis is a leading cause of","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1699,1663],[1699,1714],[245,1714]],"region":{"top_left_x":244,"top_left_y":1662,"width":1456,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14f9e778612e4b698c32e6f16c3e5084","type":"text","conversion_output":true,"text":"nosocomial mortality and staphylococci are the leading cause of sepsis in the US. \\({ }^{14, ~}{ }^{15}\\)","text_display":" nosocomial mortality and staphylococci are the leading cause of sepsis in the US. \\({ }^{14, ~}{ }^{15}\\)","confidence":0.5966375783444278,"confidence_rate":0.9951397229400836},{"cnt":[[245,1736],[1794,1736],[1794,1783],[245,1783]],"region":{"top_left_x":244,"top_left_y":1735,"width":1550,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16b3e70813e84f3a86331c43731cae91","type":"text","conversion_output":true,"text":"Mortality among patients with untreated blood stream infection exceeds \\(80 \\% .{ }^{16}\\) As a result,","text_display":"\n\nMortality among patients with untreated blood stream infection exceeds \\(80 \\% .{ }^{16}\\) As a result,","confidence":0.81982421875,"confidence_rate":0.9981097380465213},{"cnt":[[245,1783],[1828,1783],[1828,1833],[245,1833]],"region":{"top_left_x":244,"top_left_y":1783,"width":1585,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3b099872e414cb392613fec3b188cda","type":"text","conversion_output":true,"text":"many patients with staphylococcal blood stream infection require antibiotic therapy, often with","text_display":" many patients with staphylococcal blood stream infection require antibiotic therapy, often with","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1813,1835],[1813,1884],[245,1884]],"region":{"top_left_x":244,"top_left_y":1834,"width":1570,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ea3f94741e840eb9e16d776af5c5658","type":"text","conversion_output":true,"text":"vancomycin. However, every patient with staphylococci isolated from blood cultures may not","text_display":" vancomycin. However, every patient with staphylococci isolated from blood cultures may not","confidence":1,"confidence_rate":1},{"cnt":[[245,1886],[1025,1886],[1025,1936],[245,1936]],"region":{"top_left_x":244,"top_left_y":1886,"width":781,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8359e105858c4c748c038bf39e19cf6a","type":"text","conversion_output":true,"text":"require prolonged treatment with vancomycin.","text_display":" require prolonged treatment with vancomycin.","confidence":1,"confidence_rate":1},{"cnt":[[241,1972],[1605,1972],[1605,2035],[241,2035]],"region":{"top_left_x":240,"top_left_y":1972,"width":1365,"height":63},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e955cfc8bf4f4dbf9435905dcb9ba064","type":"section_header","conversion_output":false,"children_ids":["3a15423fa25e42a4a81646fcec8f65dd"],"text":"","text_display":""},{"cnt":[[245,1979],[1601,1979],[1601,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1978,"width":1357,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a15423fa25e42a4a81646fcec8f65dd","type":"text","conversion_output":true,"parent_id":"e955cfc8bf4f4dbf9435905dcb9ba064","text":"2.1.2 Management of Intravenous Catheter-associated Infections","text_display":"\n\n\\subsection*{2.1.2 Management of Intravenous Catheter-associated Infections}","confidence":0.9951171875,"confidence_rate":0.9999269463644165},{"cnt":[[247,2045],[1841,2045],[1841,2095],[247,2095]],"region":{"top_left_x":247,"top_left_y":2045,"width":1595,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a4d567c798e44a7834c52f6506802ad","type":"text","conversion_output":true,"text":"Intravenous catheter-associated blood stream infection is a frequent nosocomial complication.","text_display":"\n\nIntravenous catheter-associated blood stream infection is a frequent nosocomial complication.","confidence":1,"confidence_rate":1},{"cnt":[[245,2097],[1861,2097],[1861,2146],[245,2146]],"region":{"top_left_x":244,"top_left_y":2096,"width":1617,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0815d0b2f2d427db9ff229a555b5d16","type":"text","conversion_output":true,"text":"Caused primarily by staphylococci (S. aureus and coagulase negative staphylococcus [CoNS]),","text_display":" Caused primarily by staphylococci (S. aureus and coagulase negative staphylococcus [CoNS]),","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[245,2144],[1869,2144],[1869,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2144,"width":1626,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0d4306dfe044287ad539bd714defd33","type":"text","conversion_output":true,"text":"these infections can often be treated with a short course of antibiotics. However, in a minority of","text_display":" these infections can often be treated with a short course of antibiotics. However, in a minority of","confidence":0.9990234375,"confidence_rate":0.9999906054321309},{"cnt":[[245,2196],[1818,2196],[1818,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":1574,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09b2c000f2004f139c1820e696ed9738","type":"text","conversion_output":true,"text":"cases severe, even life-threatening complications occur, including but not limited to: infective","text_display":" cases severe, even life-threatening complications occur, including but not limited to: infective","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1803,2247],[1803,2297],[245,2297]],"region":{"top_left_x":244,"top_left_y":2247,"width":1559,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d240978596e44d34805ecef7f35a4998","type":"text","conversion_output":true,"text":"endocarditis, septic arthritis, deep tissue abscess, vertebral osteomyelitis, epidural abscess,","text_display":" endocarditis, septic arthritis, deep tissue abscess, vertebral osteomyelitis, epidural abscess,","confidence":1,"confidence_rate":1},{"cnt":[[245,2295],[1300,2295],[1300,2346],[245,2346]],"region":{"top_left_x":244,"top_left_y":2294,"width":1056,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81c39c53f4d743079d380d99dbe4a4e8","type":"text","conversion_output":true,"text":"septic thrombophlebitis, psoas abscess, and meningitis. \\({ }^{17},{ }^{18, ~}{ }^{19}\\)","text_display":" septic thrombophlebitis, psoas abscess, and meningitis. \\({ }^{17},{ }^{18, ~}{ }^{19}\\)","confidence":0.2589492320098543,"confidence_rate":0.9850996449146748},{"cnt":[[245,2363],[1742,2363],[1742,2413],[245,2413]],"region":{"top_left_x":244,"top_left_y":2363,"width":1499,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ac74cc66f43497fa0ff3d8896ad7cd5","type":"text","conversion_output":true,"text":"Catheter removal is a critical component in the treatment of catheter-related infections. \\({ }^{20}\\)","text_display":"\nCatheter removal is a critical component in the treatment of catheter-related infections. \\({ }^{20}\\)","confidence":1,"confidence_rate":1},{"cnt":[[245,2415],[1846,2415],[1846,2464],[245,2464]],"region":{"top_left_x":244,"top_left_y":2414,"width":1602,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a3f8bd4228c4afd834c3558efb5810b","type":"text","conversion_output":true,"text":"However, there are clinical situations-such as patients with limited vascular access options-","text_display":" However, there are clinical situations-such as patients with limited vascular access options-","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[1048,2557],[1079,2557],[1079,2593],[1048,2593]],"region":{"top_left_x":1048,"top_left_y":2556,"width":31,"height":38},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8090cd6faf8b4b399933cf42d78c6167","type":"page_info","conversion_output":false,"text":"4","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-019","page":19,"lines":[{"cnt":[[245,198],[1059,198],[1059,238],[245,238]],"region":{"top_left_x":244,"top_left_y":197,"width":816,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d521f4643fef4c6d91c8698b1cbfac48","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,200],[1878,200],[1878,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":199,"width":168,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72c64ca330fe4446b2a0a89f0d7ee583","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1880,236],[1880,269],[1603,269]],"region":{"top_left_x":1602,"top_left_y":236,"width":278,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7b5c8be036743bcbba6abcb0690614b","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,309],[1609,309],[1609,354],[245,354]],"region":{"top_left_x":244,"top_left_y":309,"width":1366,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"384e081aa80046e3ad833540b922b6f6","type":"text","conversion_output":true,"text":"where the intravenous catheter needs to be left in place. Therefore, treatment of","text_display":"\nwhere the intravenous catheter needs to be left in place. Therefore, treatment of","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[1790,357],[1790,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1546,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce6c29a491974bbcac7b9ae8ce024d55","type":"text","conversion_output":true,"text":"catheter-associated infections becomes complicated in terms of the decision to remove the","text_display":" catheter-associated infections becomes complicated in terms of the decision to remove the","confidence":0.9931640625,"confidence_rate":0.9999270302203931},{"cnt":[[245,408],[1646,408],[1646,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":1402,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f367d317493f498b97e453a5a495358a","type":"text","conversion_output":true,"text":"catheter as well as in determining the drug of choice and the duration of treatment.","text_display":" catheter as well as in determining the drug of choice and the duration of treatment.","confidence":1,"confidence_rate":1},{"cnt":[[245,477],[1727,477],[1727,526],[245,526]],"region":{"top_left_x":244,"top_left_y":476,"width":1484,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77bc6ad69efd4db6ac16d9bb2baaa4bb","type":"text","conversion_output":true,"text":"In 2001, the Infectious Diseases Society of America (IDSA) published guidelines for the","text_display":"\n\nIn 2001, the Infectious Diseases Society of America (IDSA) published guidelines for the","confidence":1,"confidence_rate":1},{"cnt":[[245,524],[1858,524],[1858,574],[245,574]],"region":{"top_left_x":244,"top_left_y":524,"width":1615,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"215a99e4c0ec4ad9af2590da326df4ea","type":"text","conversion_output":true,"text":"management of catheter-associated infections. \\({ }^{20}\\) Guidelines were revised in 2009. \\({ }^{21}\\) Catheter","text_display":" management of catheter-associated infections. \\({ }^{20}\\) Guidelines were revised in 2009. \\({ }^{21}\\) Catheter","confidence":0.9722318160465875,"confidence_rate":0.9997613758559342},{"cnt":[[245,576],[1760,576],[1760,621],[245,621]],"region":{"top_left_x":244,"top_left_y":575,"width":1516,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9ae7cf903244fd18e916e25fcecbe71","type":"text","conversion_output":true,"text":"removal was recommended in most cases of non-tunneled catheter-associated infections","text_display":" removal was recommended in most cases of non-tunneled catheter-associated infections","confidence":0.99951171875,"confidence_rate":0.9999945123690109},{"cnt":[[245,627],[1742,627],[1742,675],[245,675]],"region":{"top_left_x":244,"top_left_y":627,"width":1499,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c700cbcf4ef842e1a80f23061b84a555","type":"text","conversion_output":true,"text":"following completion of blood cultures and other appropriate diagnostic tests. It was also","text_display":" following completion of blood cultures and other appropriate diagnostic tests. It was also","confidence":1,"confidence_rate":1},{"cnt":[[245,677],[1826,677],[1826,724],[245,724]],"region":{"top_left_x":244,"top_left_y":676,"width":1583,"height":49},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a2bd4fe5eaa41ada90e6f02187c0148","type":"text","conversion_output":true,"text":"recommended that intravenous therapy be initiated on the basis of clinical clues, the patient's","text_display":" recommended that intravenous therapy be initiated on the basis of clinical clues, the patient's","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[1828,726],[1828,776],[245,776]],"region":{"top_left_x":244,"top_left_y":726,"width":1585,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67bfaf52d7f1453a823c73cdfce24bc4","type":"text","conversion_output":true,"text":"condition, and the potential pathogen involved. Unfortunately, these clinical clues are far from","text_display":" condition, and the potential pathogen involved. Unfortunately, these clinical clues are far from","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1738,778],[1738,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1495,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb3f3cae9a494960bda3c6307a95f4eb","type":"text","conversion_output":true,"text":"perfect in establishing a diagnosis of catheter-associated infection because of their poor","text_display":" perfect in establishing a diagnosis of catheter-associated infection because of their poor","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1830,825],[1830,879],[245,879]],"region":{"top_left_x":244,"top_left_y":825,"width":1587,"height":54},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bad1ba6f92b4f50b28ed84142b3bcd1","type":"text","conversion_output":true,"text":"specificity and sensitivity. \\({ }^{21}\\) For example, in a recent prospective cohort study of patients with","text_display":" specificity and sensitivity. \\({ }^{21}\\) For example, in a recent prospective cohort study of patients with","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1858,877],[1858,924],[245,924]],"region":{"top_left_x":244,"top_left_y":876,"width":1615,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74102c5f95844fc1b78ae4931f9b374c","type":"text","conversion_output":true,"text":"central venous catheter-associated \\(S\\). aureus blood stream infection, we demonstrated that the","text_display":" central venous catheter-associated \\(S\\). aureus blood stream infection, we demonstrated that the","confidence":0.9926843643188477,"confidence_rate":0.9999280170401967},{"cnt":[[245,928],[1807,928],[1807,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":1563,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e08b697e9934045946245a4af6567fe","type":"text","conversion_output":true,"text":"sensitivity of physical examination findings for ultrasonogram-confirmed catheter-associated","text_display":" sensitivity of physical examination findings for ultrasonogram-confirmed catheter-associated","confidence":1,"confidence_rate":1},{"cnt":[[245,975],[1871,975],[1871,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":975,"width":1628,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72792168deb6406cb3d23fbf66d2ae0c","type":"text","conversion_output":true,"text":"thrombosis was only \\(24 \\% .{ }^{19}\\) Blood cultures that yield CoNS or S. aureus increase the suspicion","text_display":" thrombosis was only \\(24 \\% .{ }^{19}\\) Blood cultures that yield CoNS or S. aureus increase the suspicion","confidence":0.9241824983619153,"confidence_rate":0.9992702134812822},{"cnt":[[245,1027],[1760,1027],[1760,1074],[245,1074]],"region":{"top_left_x":244,"top_left_y":1026,"width":1516,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd0939bef4bd4432af6f9892dba57461","type":"text","conversion_output":true,"text":"for catheter-associated infections, but do not exclude additional sites of infection, such as","text_display":" for catheter-associated infections, but do not exclude additional sites of infection, such as","confidence":1,"confidence_rate":1},{"cnt":[[245,1079],[1184,1079],[1184,1126],[245,1126]],"region":{"top_left_x":244,"top_left_y":1078,"width":940,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3d870f82eba4c2ab3833e267891a5a1","type":"text","conversion_output":true,"text":"endocarditis, septic thrombophlebitis, or septic arthritis.","text_display":" endocarditis, septic thrombophlebitis, or septic arthritis.","confidence":1,"confidence_rate":1},{"cnt":[[245,1147],[1768,1147],[1768,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1147,"width":1525,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ce1fa68047848f68256900e9ca8c3e5","type":"text","conversion_output":true,"text":"Additionally, management of staphylococcal bloodstream infection may differ according to","text_display":"\n\nAdditionally, management of staphylococcal bloodstream infection may differ according to","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1841,1195],[1841,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1194,"width":1598,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e525e24fdfc0425da290ae3c6b0b58f1","type":"text","conversion_output":true,"text":"whether the infection is nosocomial, health care-associated, or community acquired. This trial","text_display":" whether the infection is nosocomial, health care-associated, or community acquired. This trial","confidence":1,"confidence_rate":1},{"cnt":[[245,1246],[1863,1246],[1863,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1246,"width":1619,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eebfc21e1aa44c84af40dd9e70536d94","type":"text","conversion_output":true,"text":"will enroll patients with staphylococcal infections from these various settings, to better delineate","text_display":" will enroll patients with staphylococcal infections from these various settings, to better delineate","confidence":1,"confidence_rate":1},{"cnt":[[245,1298],[1764,1298],[1764,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1297,"width":1520,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5755834b4d74360abdfe0cc2ebca17b","type":"text","conversion_output":true,"text":"appropriate management of staphylococcal bacteremia across all settings encountered in","text_display":" appropriate management of staphylococcal bacteremia across all settings encountered in","confidence":0.99853515625,"confidence_rate":0.999983891144227},{"cnt":[[245,1345],[522,1345],[522,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":279,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73a8e586f76d48149cbee39107c8a1d6","type":"text","conversion_output":true,"text":"clinical practice.","text_display":" clinical practice.","confidence":1,"confidence_rate":1},{"cnt":[[241,1457],[604,1457],[604,1515],[241,1515]],"region":{"top_left_x":240,"top_left_y":1456,"width":364,"height":59},"line":25,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"e8bd1a597d194affaa53055bdd31313b","type":"section_header","conversion_output":false,"children_ids":["51573e02877c4fd089ccac7c06a77d5b"],"text":"","text_display":""},{"cnt":[[245,1461],[597,1461],[597,1510],[245,1510]],"region":{"top_left_x":244,"top_left_y":1460,"width":354,"height":51},"line":26,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"51573e02877c4fd089ccac7c06a77d5b","type":"text","conversion_output":true,"parent_id":"e8bd1a597d194affaa53055bdd31313b","text":"2.2 Rationale","text_display":"\n\n\\subsection*{2.2 Rationale}","confidence":1,"confidence_rate":1},{"cnt":[[245,1540],[1824,1540],[1824,1588],[245,1588]],"region":{"top_left_x":244,"top_left_y":1540,"width":1581,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fa529f83b404208927fc65f9b954adc","type":"text","conversion_output":true,"text":"Accurately differentiating patients with severe staphylococcal blood stream infection requiring","text_display":"\n\nAccurately differentiating patients with severe staphylococcal blood stream infection requiring","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[245,1590],[1865,1590],[1865,1637],[245,1637]],"region":{"top_left_x":244,"top_left_y":1589,"width":1621,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcfb9938a91c4d02a7585a7bd480237b","type":"text","conversion_output":true,"text":"extended courses of vancomycin from those patients whose condition could safely receive brief","text_display":" extended courses of vancomycin from those patients whose condition could safely receive brief","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1824,1641],[1824,1687],[245,1687]],"region":{"top_left_x":244,"top_left_y":1641,"width":1581,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89572f8e70d24e0ba4a26954fa4968fe","type":"text","conversion_output":true,"text":"durations of therapy could allow clinicians to treat patients appropriately while simultaneously","text_display":" durations of therapy could allow clinicians to treat patients appropriately while simultaneously","confidence":1,"confidence_rate":1},{"cnt":[[245,1691],[1854,1691],[1854,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1690,"width":1611,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"635c9a7a931a46ada9fef553eff45e4d","type":"text","conversion_output":true,"text":"limiting unnecessary vancomycin use. In this clinical trial, we will describe treatment algorithms","text_display":" limiting unnecessary vancomycin use. In this clinical trial, we will describe treatment algorithms","confidence":1,"confidence_rate":1},{"cnt":[[245,1740],[1837,1740],[1837,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1740,"width":1593,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3db134cc41ce4a3aa5e1cbddd493b018","type":"text","conversion_output":true,"text":"based upon clinical, echocardiographic, and laboratory features to identify which patients may","text_display":" based upon clinical, echocardiographic, and laboratory features to identify which patients may","confidence":1,"confidence_rate":1},{"cnt":[[245,1792],[1285,1792],[1285,1841],[245,1841]],"region":{"top_left_x":244,"top_left_y":1791,"width":1041,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"289a55e483dd47f996e642b9b561f7aa","type":"text","conversion_output":true,"text":"safely and successfully undergo shortened antibiotic therapy.","text_display":" safely and successfully undergo shortened antibiotic therapy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1858],[1824,1858],[1824,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1858,"width":1581,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96b15d79fd5243419f2c325fcccfc56f","type":"text","conversion_output":true,"text":"The purpose of this clinical trial is to accurately determine the complication potential and thus","text_display":"\nThe purpose of this clinical trial is to accurately determine the complication potential and thus","confidence":1,"confidence_rate":1},{"cnt":[[245,1908],[1792,1908],[1792,1957],[245,1957]],"region":{"top_left_x":244,"top_left_y":1907,"width":1548,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"320e44de32114f098293f540526b75f6","type":"text","conversion_output":true,"text":"the length of appropriate therapy for staphylococcal blood stream infection, allowing careful","text_display":" the length of appropriate therapy for staphylococcal blood stream infection, allowing careful","confidence":1,"confidence_rate":1},{"cnt":[[245,1959],[1785,1959],[1785,2007],[245,2007]],"region":{"top_left_x":244,"top_left_y":1959,"width":1542,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6b3131370684e71baf4500d54cefd8a","type":"text","conversion_output":true,"text":"stewardship of our remaining antibiotic resources. In addition, the current protocol seeks to","text_display":" stewardship of our remaining antibiotic resources. In addition, the current protocol seeks to","confidence":1,"confidence_rate":1},{"cnt":[[245,2011],[1760,2011],[1760,2056],[245,2056]],"region":{"top_left_x":244,"top_left_y":2010,"width":1516,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac590d1941934b4c94e88c78dffb8539","type":"text","conversion_output":true,"text":"address important aspects of the management of staphylococcal blood stream infections.","text_display":" address important aspects of the management of staphylococcal blood stream infections.","confidence":1,"confidence_rate":1},{"cnt":[[245,2075],[1760,2075],[1760,2125],[245,2125]],"region":{"top_left_x":244,"top_left_y":2075,"width":1516,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a5def713ae549c18e9e936530762ba7","type":"text","conversion_output":true,"text":"This study is particularly important since there are no clearly defined universally accepted","text_display":"\n\nThis study is particularly important since there are no clearly defined universally accepted","confidence":1,"confidence_rate":1},{"cnt":[[245,2127],[1807,2127],[1807,2176],[245,2176]],"region":{"top_left_x":244,"top_left_y":2126,"width":1563,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e9bec2dd551440d9d871ca797b2656e","type":"text","conversion_output":true,"text":"guidelines for the treatment duration of patients with blood stream staphylococcal infections.","text_display":" guidelines for the treatment duration of patients with blood stream staphylococcal 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2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,305],[1038,305],[1038,367],[241,367]],"region":{"top_left_x":240,"top_left_y":305,"width":798,"height":63},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"feda814cf00d429eacc73b828b6d16bf","type":"section_header","conversion_output":false,"children_ids":["e2e0884aa46d44b397d8873845492647"],"text":"","text_display":""},{"cnt":[[245,309],[1033,309],[1033,363],[245,363]],"region":{"top_left_x":244,"top_left_y":309,"width":790,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2e0884aa46d44b397d8873845492647","type":"text","conversion_output":true,"parent_id":"feda814cf00d429eacc73b828b6d16bf","text":"2.3 Potential Risks and Benefits","text_display":"\n\n\\subsection*{2.3 Potential Risks and Benefits}","confidence":1,"confidence_rate":1},{"cnt":[[236,408],[733,408],[733,466],[236,466]],"region":{"top_left_x":236,"top_left_y":408,"width":497,"height":59},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b18723bc59014bf59c467b1d3cc1cf7e","type":"section_header","conversion_output":false,"children_ids":["9bc6a77ad2c64cfab5e984e020cd316b"],"text":"","text_display":""},{"cnt":[[245,412],[728,412],[728,462],[245,462]],"region":{"top_left_x":244,"top_left_y":412,"width":485,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bc6a77ad2c64cfab5e984e020cd316b","type":"text","conversion_output":true,"parent_id":"b18723bc59014bf59c467b1d3cc1cf7e","text":"2.3.1 Potential Risks","text_display":"\n\n\\subsection*{2.3.1 Potential Risks}","confidence":0.994145393371582,"confidence_rate":0.9997741865756689},{"cnt":[[245,503],[1762,503],[1762,552],[245,552]],"region":{"top_left_x":244,"top_left_y":502,"width":1518,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d87c795b9dd34c199fa1a9fa6ae44495","type":"text","conversion_output":true,"text":"This clinical trial compares the efficacy and safety of algorithm-based antibiotic therapy to","text_display":"\n\nThis clinical trial compares the efficacy and safety of algorithm-based antibiotic therapy to","confidence":1,"confidence_rate":1},{"cnt":[[245,552],[1830,552],[1830,604],[245,604]],"region":{"top_left_x":244,"top_left_y":552,"width":1587,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aad0001125bb4a5997e4de8baca3b4cf","type":"text","conversion_output":true,"text":"standard therapy for the treatment of staphylococcal bacteremia. The primary potential risk of","text_display":" standard therapy for the treatment of staphylococcal bacteremia. The primary potential risk of","confidence":1,"confidence_rate":1},{"cnt":[[245,604],[1858,604],[1858,655],[245,655]],"region":{"top_left_x":244,"top_left_y":603,"width":1615,"height":53},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63363db4f8414b009699abc1e1bebc85","type":"text","conversion_output":true,"text":"the study is that the duration of antibiotic therapy is inappropriately short. For example, patients","text_display":" the study is that the duration of antibiotic therapy is inappropriately short. For example, patients","confidence":1,"confidence_rate":1},{"cnt":[[245,653],[1835,653],[1835,703],[245,703]],"region":{"top_left_x":244,"top_left_y":653,"width":1591,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eeac93531c91440b9e8e263a7c1021f5","type":"text","conversion_output":true,"text":"randomized to algorithm-based therapy may receive shorter courses of antibiotic therapy than","text_display":" randomized to algorithm-based therapy may receive shorter courses of antibiotic therapy than","confidence":1,"confidence_rate":1},{"cnt":[[245,700],[1841,700],[1841,752],[245,752]],"region":{"top_left_x":244,"top_left_y":700,"width":1598,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd74c23bdd194fabbcaa1afdd7d91f82","type":"text","conversion_output":true,"text":"required, while patients in the standard treatment arm may receive longer courses of antibiotic","text_display":" required, while patients in the standard treatment arm may receive longer courses of antibiotic","confidence":1,"confidence_rate":1},{"cnt":[[245,752],[1852,752],[1852,804],[245,804]],"region":{"top_left_x":244,"top_left_y":751,"width":1608,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be09120e67e647a182f81d98eda6a166","type":"text","conversion_output":true,"text":"therapy than necessary. If the course of antibiotics is too short, possible consequences include","text_display":" therapy than necessary. If the course of antibiotics is too short, possible consequences include","confidence":1,"confidence_rate":1},{"cnt":[[245,804],[1749,804],[1749,853],[245,853]],"region":{"top_left_x":244,"top_left_y":803,"width":1505,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bf60c70305a472c823c7a22697067bb","type":"text","conversion_output":true,"text":"failure to eradicate the staphylococcal infection, progression of infection to other sites, or","text_display":" failure to eradicate the staphylococcal infection, progression of infection to other sites, or","confidence":1,"confidence_rate":1},{"cnt":[[245,853],[1055,853],[1055,904],[245,904]],"region":{"top_left_x":244,"top_left_y":852,"width":811,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e4adce4a674457a92e1c95302dc8ce6","type":"text","conversion_output":true,"text":"subsequent relapse of staphylococcal infection.","text_display":" subsequent relapse of staphylococcal infection.","confidence":1,"confidence_rate":1},{"cnt":[[245,945],[1740,945],[1740,995],[245,995]],"region":{"top_left_x":244,"top_left_y":945,"width":1497,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a3fd61b3f114dc89a28097d58f62ab6","type":"text","conversion_output":true,"text":"All antibiotics used in this trial are commercially available; however, a second risk is that","text_display":"\n\nAll antibiotics used in this trial are commercially available; however, a second risk is that","confidence":1,"confidence_rate":1},{"cnt":[[245,997],[1803,997],[1803,1046],[245,1046]],"region":{"top_left_x":244,"top_left_y":996,"width":1559,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"054e992337da476c9ffca5afe220de29","type":"text","conversion_output":true,"text":"antibiotic therapy will lead to adverse events (AEs) related to the antimicrobial therapy. The","text_display":" antibiotic therapy will lead to adverse events (AEs) related to the antimicrobial therapy. 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A summary of major AEs associated with these antibiotics is provided below. Please","text_display":" study. A summary of major AEs associated with these antibiotics is provided below. 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Treatment with antibacterial agents alters the normal flora of the colon leading to","text_display":" colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to","confidence":1,"confidence_rate":1},{"cnt":[[370,1532],[1863,1532],[1863,1583],[370,1583]],"region":{"top_left_x":369,"top_left_y":1531,"width":1494,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7043121cc3bc481da8aec9b339e8643a","type":"text","conversion_output":true,"text":"overgrowth of C. difficile. If CDAD is suspected or confirmed, ongoing antibiotic use not","text_display":" overgrowth of C. difficile. If CDAD is suspected or confirmed, ongoing antibiotic use not","confidence":0.99755859375,"confidence_rate":0.9999739961748949},{"cnt":[[370,1583],[1708,1583],[1708,1635],[370,1635]],"region":{"top_left_x":369,"top_left_y":1583,"width":1340,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbe5c6df197442389f3816859c6fe1a1","type":"text","conversion_output":true,"text":"directed against C. difficile may need to be discontinued. Appropriate fluid and","text_display":" directed against C. difficile may need to be discontinued. 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A few dozen cases of hearing loss associated with vancomycin","text_display":"\n- Ototoxicity - A few dozen cases of hearing loss associated with vancomycin","confidence":1,"confidence_rate":1},{"cnt":[[370,2133],[1833,2133],[1833,2185],[370,2185]],"region":{"top_left_x":369,"top_left_y":2133,"width":1464,"height":52},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8a2ae396f5b4bbb9a22d50a19c4d28f","type":"text","conversion_output":true,"text":"hydrochloride have been reported. 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However, some patients with \\(S\\). aureus bacteremia with no","confidence":0.7434072494506836,"confidence_rate":0.9970972479258488},{"cnt":[[245,1869],[1738,1869],[1738,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1869,"width":1495,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"175acc055db94f798bf6cf95d338f580","type":"text","conversion_output":true,"text":"apparent complications at randomization will be identified by the study evaluation (blood","text_display":" apparent complications at randomization will be identified by the study evaluation (blood","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,1921],[1830,1921],[1830,1968],[245,1968]],"region":{"top_left_x":244,"top_left_y":1920,"width":1587,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be07189316b34890a4cf47a4c5ad8fe8","type":"text","conversion_output":true,"text":"cultures, echocardiography) after randomization but on or before completion of the treatment","text_display":" cultures, echocardiography) after randomization but on or before completion of the treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1968],[1876,1968],[1876,2017],[245,2017]],"region":{"top_left_x":244,"top_left_y":1967,"width":1632,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a1c44e9c3474b93b9fc06c4ee5a1d9b","type":"text","conversion_output":true,"text":"period for the baseline clinical classification of bacteremia. These patients will remain in the trial,","text_display":" period for the baseline clinical classification of bacteremia. These patients will remain in the trial,","confidence":1,"confidence_rate":1},{"cnt":[[245,2020],[1858,2020],[1858,2069],[245,2069]],"region":{"top_left_x":244,"top_left_y":2019,"width":1615,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a4f9c6451834621a99b094354fc9c5b","type":"text","conversion_output":true,"text":"will be categorized as Complicated S. aureus bacteremia, and will be treated per Protocol. For","text_display":" will be categorized as Complicated S. aureus bacteremia, and will be treated per Protocol. For","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,2069],[937,2069],[937,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2068,"width":693,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef2bbbab585f434186d149d390a861d0","type":"text","conversion_output":true,"text":"such patients, \"Cure\" will be defined as -","text_display":" such patients, \"Cure\" will be defined as -","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[370,2168],[1760,2168],[1760,2215],[370,2215]],"region":{"top_left_x":369,"top_left_y":2167,"width":1391,"height":49},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afb1ddbc958840419dd3ccb736a0d3c5","type":"text","conversion_output":true,"text":"- Resolution of bacteremia as demonstrated by negative follow-up blood culture","text_display":"\n- Resolution of bacteremia as demonstrated by negative follow-up blood culture","confidence":1,"confidence_rate":1},{"cnt":[[370,2243],[1841,2243],[1841,2292],[370,2292]],"region":{"top_left_x":369,"top_left_y":2242,"width":1473,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6de453902b4344c48e3e71d1e4d1fbbd","type":"text","conversion_output":true,"text":"- Clinical resolution of signs and symptoms of staphylococcal blood stream infection;","text_display":"\n- Clinical resolution of signs and symptoms of staphylococcal blood stream infection;","confidence":1,"confidence_rate":1},{"cnt":[[432,2295],[505,2295],[505,2335],[432,2335]],"region":{"top_left_x":431,"top_left_y":2294,"width":74,"height":42},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d7e972614f448fcb76847b2d2a115bf","type":"text","conversion_output":true,"text":"and","text_display":" and","confidence":1,"confidence_rate":1},{"cnt":[[370,2372],[1867,2372],[1867,2421],[370,2421]],"region":{"top_left_x":369,"top_left_y":2371,"width":1498,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06fbae4a4bdf4d1e91181594ef52282b","type":"text","conversion_output":true,"text":"- No development of a) persisting infection; b) relapsing infection; or c) additional sites","text_display":"\n- No development of a) persisting infection; b) relapsing infection; or c) additional sites","confidence":1,"confidence_rate":1},{"cnt":[[432,2419],[1732,2419],[1732,2469],[432,2469]],"region":{"top_left_x":431,"top_left_y":2419,"width":1301,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44c13379a87e4f53b05edc28d0e0cad4","type":"text","conversion_output":true,"text":"of complicated staphylococcal infection, up to the respective TOC evaluation","text_display":" of complicated staphylococcal infection, up to the respective TOC evaluation","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2595],[1038,2595]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":40},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f53e3a0177f41bbb7f2f2766bfcc0d2","type":"page_info","conversion_output":false,"text":"19","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-034","page":34,"lines":[{"cnt":[[245,200],[1059,200],[1059,238],[245,238]],"region":{"top_left_x":244,"top_left_y":199,"width":816,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4bfb1f88b28b45b9b03078761113b0e4","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,202],[1876,202],[1876,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":201,"width":166,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f053c6c823c74e378db21f147bfbe5ac","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1880,236],[1880,269],[1603,269]],"region":{"top_left_x":1602,"top_left_y":236,"width":278,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93053dc0365a4fb7b737ffbf0205a789","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,305],[954,305],[954,363],[241,363]],"region":{"top_left_x":240,"top_left_y":305,"width":714,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97cfa25d72024fb982cb067ca1cee88b","type":"section_header","conversion_output":false,"children_ids":["35d58b1edc604fd8a6433ee7951ff9e5"],"text":"","text_display":""},{"cnt":[[245,309],[947,309],[947,359],[245,359]],"region":{"top_left_x":244,"top_left_y":309,"width":704,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35d58b1edc604fd8a6433ee7951ff9e5","type":"text","conversion_output":true,"parent_id":"97cfa25d72024fb982cb067ca1cee88b","text":"3.2.4 Committees and Helplines","text_display":"\n\n\\subsection*{3.2.4 Committees and Helplines}","confidence":1,"confidence_rate":1},{"cnt":[[245,397],[1837,397],[1837,445],[245,445]],"region":{"top_left_x":244,"top_left_y":397,"width":1593,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06d64ac6f05647fe90ebb28316249fd9","type":"text","conversion_output":true,"text":"There are 3 committees and 2 help lines. The responsibilities for each committee/helpline are","text_display":"\n\nThere are 3 committees and 2 help lines. The responsibilities for each committee/helpline are","confidence":1,"confidence_rate":1},{"cnt":[[245,449],[1248,449],[1248,496],[245,496]],"region":{"top_left_x":244,"top_left_y":449,"width":1005,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01a05d6dbc0241f689ae9b2776b5f1fb","type":"text","conversion_output":true,"text":"listed below and will be referenced throughout the protocol.","text_display":" listed below and will be referenced throughout the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[241,535],[965,535],[965,591],[241,591]],"region":{"top_left_x":240,"top_left_y":534,"width":725,"height":57},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46394596b92b438bb8cb985bc6cc6959","type":"section_header","conversion_output":false,"children_ids":["352081149bf74a7fbdfb9b1e53b41f87"],"text":"","text_display":""},{"cnt":[[245,541],[960,541],[960,587],[245,587]],"region":{"top_left_x":244,"top_left_y":541,"width":717,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"352081149bf74a7fbdfb9b1e53b41f87","type":"text","conversion_output":true,"parent_id":"46394596b92b438bb8cb985bc6cc6959","text":"3.2.4.1 Clinical Event Committee (CEC)","text_display":"\n\n\\subsection*{3.2.4.1 Clinical Event Committee (CEC)}","confidence":0.9990236759185791,"confidence_rate":0.9999772839557756},{"cnt":[[245,625],[1846,625],[1846,672],[245,672]],"region":{"top_left_x":244,"top_left_y":625,"width":1602,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15f3e28d566b4ab4b4041136021601b1","type":"text","conversion_output":true,"text":"The CEC will consist of 3 physicians with expertise in infectious diseases who are not involved","text_display":"\n\nThe CEC will consist of 3 physicians with expertise in infectious diseases who are not involved","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[245,675],[1854,675],[1854,724],[245,724]],"region":{"top_left_x":244,"top_left_y":674,"width":1611,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"647fa66e8a4e4f15997504b0e6829593","type":"text","conversion_output":true,"text":"in study conduct. The CEC will develop a charter and will adjudicate events on at least a yearly","text_display":" in study conduct. The CEC will develop a charter and will adjudicate events on at least a yearly","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[1635,726],[1635,776],[245,776]],"region":{"top_left_x":244,"top_left_y":726,"width":1391,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0351e7ee18cc4ee9bce41121a19daf53","type":"text","conversion_output":true,"text":"basis. All CEC members will be blinded to randomization and treatment category.","text_display":" basis. All CEC members will be blinded to randomization and treatment category.","confidence":1,"confidence_rate":1},{"cnt":[[245,816],[1824,816],[1824,866],[245,866]],"region":{"top_left_x":244,"top_left_y":816,"width":1581,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cef97a69dc04738be38420c2a18b215","type":"text","conversion_output":true,"text":"The CEC Review Committee will be responsible for defining the presence and significance of","text_display":"\n\nThe CEC Review Committee will be responsible for defining the presence and significance of","confidence":1,"confidence_rate":1},{"cnt":[[245,868],[1772,868],[1772,917],[245,917]],"region":{"top_left_x":244,"top_left_y":867,"width":1529,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e1577bac35449d0812b6b2f574e049a","type":"text","conversion_output":true,"text":"potentially effective nonstudy (PENS) antibiotics received from the time of collection of the","text_display":" potentially effective nonstudy (PENS) antibiotics received from the time of collection of the","confidence":1,"confidence_rate":1},{"cnt":[[245,917],[1833,917],[1833,965],[245,965]],"region":{"top_left_x":244,"top_left_y":917,"width":1589,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f9cb0ae7f00417bba4e4bb02cc1f74f","type":"text","conversion_output":true,"text":"baseline blood culture until final TOC based upon review of all available culture, susceptibility,","text_display":" baseline blood culture until final TOC based upon review of all available culture, susceptibility,","confidence":1,"confidence_rate":1},{"cnt":[[245,967],[1772,967],[1772,1012],[245,1012]],"region":{"top_left_x":244,"top_left_y":966,"width":1529,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2ef634aae9f40bbb65a70d714afead9","type":"text","conversion_output":true,"text":"and antibiotic administration data. In addition, the CEC will evaluate clinical outcomes and","text_display":" and antibiotic administration data. In addition, the CEC will evaluate clinical outcomes and","confidence":1,"confidence_rate":1},{"cnt":[[245,1016],[1749,1016],[1749,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1016,"width":1505,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc286fa99da743ae97cedcffb47cd680","type":"text","conversion_output":true,"text":"antibiotic days in at least \\(10 \\%\\) of randomly selected patients. The DSMB will review CEC","text_display":" antibiotic days in at least \\(10 \\%\\) of randomly selected patients. The DSMB will review CEC","confidence":0.9736328125,"confidence_rate":0.9997187654944963},{"cnt":[[245,1070],[638,1070],[638,1115],[245,1115]],"region":{"top_left_x":244,"top_left_y":1069,"width":395,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a66576f9efe44add9e2cc3db0cb27c5f","type":"text","conversion_output":true,"text":"adjudication decisions.","text_display":" adjudication decisions.","confidence":1,"confidence_rate":1},{"cnt":[[243,1156],[866,1156],[866,1214],[243,1214]],"region":{"top_left_x":242,"top_left_y":1155,"width":624,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cd05ce96c7d4a8b96a325ebc78c7c11","type":"section_header","conversion_output":false,"children_ids":["4ed8d226e84e41fca2c53ad9807b47b6"],"text":"","text_display":""},{"cnt":[[245,1160],[862,1160],[862,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1160,"width":618,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ed8d226e84e41fca2c53ad9807b47b6","type":"text","conversion_output":true,"parent_id":"3cd05ce96c7d4a8b96a325ebc78c7c11","text":"3.2.4.2 Executive Committee (EC)","text_display":"\n\n\\subsection*{3.2.4.2 Executive Committee (EC)}","confidence":1,"confidence_rate":1},{"cnt":[[245,1246],[1869,1246],[1869,1293],[245,1293]],"region":{"top_left_x":244,"top_left_y":1246,"width":1626,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44d5b38fb5c648bb94491850068ec113","type":"text","conversion_output":true,"text":"The Executive Committee is comprised of study leadership in NIAID and DCRI. This committee","text_display":"\n\nThe Executive Committee is comprised of study leadership in NIAID and DCRI. This committee","confidence":1,"confidence_rate":1},{"cnt":[[245,1296],[1738,1296],[1738,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1295,"width":1495,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f49b3d4d3af48faacc5f2ce9ee6bbba","type":"text","conversion_output":true,"text":"is responsible for protocol development and oversight of study progress. The Executive","text_display":" is responsible for protocol development and oversight of study progress. The Executive","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1807,1345],[1807,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":1563,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b90b9e52cef4c419598509b51855e66","type":"text","conversion_output":true,"text":"Committee will meet monthly or more frequently during study start up. As study progresses,","text_display":" Committee will meet monthly or more frequently during study start up. As study progresses,","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1334,1396],[1334,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1091,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee9e3bb92b3f4801af5bd48549b282b6","type":"text","conversion_output":true,"text":"committee meeting schedule will be reassessed based on need.","text_display":" committee meeting schedule will be reassessed based on need.","confidence":1,"confidence_rate":1},{"cnt":[[241,1482],[1076,1482],[1076,1540],[241,1540]],"region":{"top_left_x":240,"top_left_y":1482,"width":837,"height":59},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4758e2b4a40147009cb311cb46511006","type":"section_header","conversion_output":false,"children_ids":["2b0bd133ba0b409980e0f7a7a6d8cda9"],"text":"","text_display":""},{"cnt":[[245,1487],[1072,1487],[1072,1536],[245,1536]],"region":{"top_left_x":244,"top_left_y":1486,"width":829,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b0bd133ba0b409980e0f7a7a6d8cda9","type":"text","conversion_output":true,"parent_id":"4758e2b4a40147009cb311cb46511006","text":"3.2.4.3 Data Safety Monitoring Board (DSMB)","text_display":"\n\n\\subsection*{3.2.4.3 Data Safety Monitoring Board (DSMB)}","confidence":0.99951171875,"confidence_rate":0.999989825041388},{"cnt":[[245,1573],[1835,1573],[1835,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1591,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7aff46fcbc354d0ca1d4fe45a5c44c88","type":"text","conversion_output":true,"text":"The DSMB is an independent body appointed and managed by DMID. The DSMB is charged","text_display":"\n\nThe DSMB is an independent body appointed and managed by DMID. The DSMB is charged","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1871,1624],[1871,1671],[245,1671]],"region":{"top_left_x":244,"top_left_y":1624,"width":1628,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5c503c9a20b4fef860aea801d4a94f1","type":"text","conversion_output":true,"text":"with monitoring patient safety throughout the trial according to their charter. Refer to Section 9.5","text_display":" with monitoring patient safety throughout the trial according to their charter. 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Arthroplasties and","confidence":1,"confidence_rate":1},{"cnt":[[370,1139],[1794,1139],[1794,1188],[370,1188]],"region":{"top_left_x":369,"top_left_y":1138,"width":1425,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"591014dd523e4779860bceedd44451a9","type":"text","conversion_output":true,"text":"other extravascular devices, e.g. synthetic hernia repair mesh, and non-arthroplasty","text_display":" other extravascular devices, e.g. synthetic hernia repair mesh, and non-arthroplasty","confidence":1,"confidence_rate":1},{"cnt":[[370,1190],[1828,1190],[1828,1240],[370,1240]],"region":{"top_left_x":369,"top_left_y":1190,"width":1460,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f9d89a9e983442caad86a2415bdf57e","type":"text","conversion_output":true,"text":"orthopedic prostheses including pins or plates, are acceptable as long as there are no","text_display":" orthopedic prostheses including pins or plates, are acceptable as long as there are no","confidence":1,"confidence_rate":1},{"cnt":[[370,1240],[1790,1240],[1790,1291],[370,1291]],"region":{"top_left_x":369,"top_left_y":1239,"width":1421,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23d1a2a4cbd747be877f21f8b010f28c","type":"text","conversion_output":true,"text":"signs or symptoms of foreign material-related infection at the time of randomization.","text_display":" signs or symptoms of foreign material-related infection at the time of randomization.","confidence":1,"confidence_rate":1},{"cnt":[[305,1332],[935,1332],[935,1377],[305,1377]],"region":{"top_left_x":305,"top_left_y":1332,"width":630,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9feffdf957db4d8e8c09f97b51fb48cd","type":"text","conversion_output":true,"text":"4. This criterion has been removed.","text_display":"\n4. This criterion has been removed.","confidence":0.9990234375,"confidence_rate":0.9999755743071165},{"cnt":[[305,1422],[1852,1422],[1852,1474],[305,1474]],"region":{"top_left_x":305,"top_left_y":1422,"width":1547,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e838f7196eca408da9666dd632cf4762","type":"text","conversion_output":true,"text":"5. Has a moribund clinical condition such that there is a high likelihood of death or cardiac","text_display":"\n5. 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Has received an investigational antibacterial agent with antistaphylococcal activity within","text_display":"\n7. Has received an investigational antibacterial agent with antistaphylococcal activity within","confidence":1,"confidence_rate":1},{"cnt":[[370,1757],[902,1757],[902,1807],[370,1807]],"region":{"top_left_x":369,"top_left_y":1757,"width":534,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dcab3dc07704e1c84d619b05885ee58","type":"text","conversion_output":true,"text":"30 days prior to randomization.","text_display":" 30 days prior to randomization.","confidence":1,"confidence_rate":1},{"cnt":[[305,1848],[1824,1848],[1824,1901],[305,1901]],"region":{"top_left_x":305,"top_left_y":1847,"width":1520,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6381e46cbd4c4cd9b50b4f241493ace2","type":"text","conversion_output":true,"text":"8. 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Note: If reduced susceptibility to vancomycin is discovered","confidence":0.99658203125,"confidence_rate":0.9999654165237842},{"cnt":[[370,2093],[1850,2093],[1850,2142],[370,2142]],"region":{"top_left_x":369,"top_left_y":2092,"width":1481,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"424effc45c374ee8997c560b5a1aef0f","type":"text","conversion_output":true,"text":"after enrollment, the patient will be treated with daptomycin (if pathogen is susceptible).","text_display":" after enrollment, the patient will be treated with daptomycin (if pathogen is susceptible).","confidence":1,"confidence_rate":1},{"cnt":[[370,2140],[1850,2140],[1850,2194],[370,2194]],"region":{"top_left_x":369,"top_left_y":2139,"width":1481,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b0474f5f9bf414b9c58214b5e4fb74d","type":"text","conversion_output":true,"text":"Patient will remain in study as appropriate and be evaluated in the ITT analysis, but will","text_display":" Patient will remain in study as appropriate and be evaluated in the ITT analysis, but will","confidence":1,"confidence_rate":1},{"cnt":[[370,2191],[904,2191],[904,2241],[370,2241]],"region":{"top_left_x":369,"top_left_y":2191,"width":536,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a17899fa87e841e9bdea6dd909f42272","type":"text","conversion_output":true,"text":"be excluded from PP analyses.","text_display":" be excluded from PP analyses.","confidence":1,"confidence_rate":1},{"cnt":[[309,2282],[1626,2282],[1626,2333],[309,2333]],"region":{"top_left_x":309,"top_left_y":2281,"width":1318,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c0bfe936b3b41ada98b4ff1b236474e","type":"text","conversion_output":true,"text":"10. For \\(S\\). Aureus patients, is severely neutropenic (absolute neutrophil count","text_display":"\n10. For \\(S\\). 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This criterion has been removed.","text_display":"\n11. This criterion has been removed.","confidence":0.9970703125,"confidence_rate":0.9999284418912624},{"cnt":[[309,400],[1828,400],[1828,449],[309,449]],"region":{"top_left_x":309,"top_left_y":399,"width":1520,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"537ea020d5c14eb4bfbd82f8f60c4a05","type":"text","conversion_output":true,"text":"12. Has previously known HIV infection with a nadir CD4+ count of < 100 cells \\(/ mm ^{3}\\) within","text_display":"\n12. Has previously known HIV infection with a nadir CD4+ count of < 100 cells \\(/ mm ^{3}\\) within","confidence":0.7939322548918426,"confidence_rate":0.997904406622149},{"cnt":[[370,451],[711,451],[711,501],[370,501]],"region":{"top_left_x":369,"top_left_y":451,"width":343,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c55cbd067a3a4f89b2c4d0dce796ff6f","type":"text","conversion_output":true,"text":"the past 12 months.","text_display":" the past 12 months.","confidence":1,"confidence_rate":1},{"cnt":[[309,541],[1833,541],[1833,591],[309,591]],"region":{"top_left_x":309,"top_left_y":541,"width":1524,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89290033a93d4596aeb300cc0323c51d","type":"text","conversion_output":true,"text":"13. Is considered unlikely to comply with study procedures or to return for scheduled post-","text_display":"\n13. Is considered unlikely to comply with study procedures or to return for scheduled post","confidence":1,"confidence_rate":1},{"cnt":[[370,593],[754,593],[754,638],[370,638]],"region":{"top_left_x":369,"top_left_y":592,"width":386,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4b686f075e848fdbac1d7494b0fbddd","type":"text","conversion_output":true,"text":"treatment evaluations.","text_display":"treatment evaluations.","confidence":1,"confidence_rate":1},{"cnt":[[309,683],[1349,683],[1349,733],[309,733]],"region":{"top_left_x":309,"top_left_y":683,"width":1041,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e43a7aa0a6f1461bab2d5a19012304f8","type":"text","conversion_output":true,"text":"14. Is pregnant or trying to get pregnant, nursing, or lactating.","text_display":"\n14. 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Has polymicrobial blood stream infection including at least one non-staphylococcal","text_display":"\n16. Has polymicrobial blood stream infection including at least one non-staphylococcal","confidence":1,"confidence_rate":1},{"cnt":[[370,1070],[1871,1070],[1871,1115],[370,1115]],"region":{"top_left_x":369,"top_left_y":1069,"width":1503,"height":47},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"550c4bf5d8234f178bcb9514397e21a9","type":"text","conversion_output":true,"text":"species, except AFTER consultation with the Clinical Medical Monitor at DCRI. Note that","text_display":" species, except AFTER consultation with the Clinical Medical Monitor at DCRI. Note that","confidence":1,"confidence_rate":1},{"cnt":[[370,1119],[1869,1119],[1869,1167],[370,1167]],"region":{"top_left_x":369,"top_left_y":1119,"width":1501,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc187c3b914048ec86438d65da80a49d","type":"text","conversion_output":true,"text":"it is possible that a subject may not have a known polymicrobial bloodstream infection at","text_display":" it is possible that a subject may not have a known polymicrobial bloodstream infection at","confidence":1,"confidence_rate":1},{"cnt":[[370,1169],[1863,1169],[1863,1216],[370,1216]],"region":{"top_left_x":369,"top_left_y":1168,"width":1494,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0599d392a64147e2b52ff1fd897e7e3a","type":"text","conversion_output":true,"text":"the time of randomization, but additional pathogen(s) can subsequently be isolated from","text_display":" the time of randomization, but additional pathogen(s) can subsequently be isolated from","confidence":0.9921875,"confidence_rate":0.9999147517049182},{"cnt":[[370,1220],[1863,1220],[1863,1265],[370,1265]],"region":{"top_left_x":369,"top_left_y":1220,"width":1494,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a7c4c96ca8f450b983dac12947fc0dc","type":"text","conversion_output":true,"text":"the initial blood culture. These patients will be eligible to remain in the trial. Please also","text_display":" the initial blood culture. These patients will be eligible to remain in the trial. 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This criterion has been removed.","text_display":"\n17. This criterion has been removed.","confidence":0.97705078125,"confidence_rate":0.9994339005002915},{"cnt":[[309,1504],[1691,1504],[1691,1549],[309,1549]],"region":{"top_left_x":309,"top_left_y":1503,"width":1382,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1108dcc281c54b769be34b12cd6fa9bf","type":"text","conversion_output":true,"text":"18. Is hemodialysis dependent or has end stage renal disease ( \\(CrCl <30 cc / min\\) ).","text_display":"\n18. 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Thus,","confidence":1,"confidence_rate":1},{"cnt":[[245,1742],[900,1742],[900,1790],[245,1790]],"region":{"top_left_x":244,"top_left_y":1742,"width":657,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"838a92bcc4eb4067baa22eb1abee7e2d","type":"text","conversion_output":true,"text":"these important data are not available.","text_display":" these important data are not available.","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1820,1835],[1820,1880],[245,1880]],"region":{"top_left_x":244,"top_left_y":1834,"width":1576,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08c4bce1f4a44a69bc412e7027fc2d93","type":"text","conversion_output":true,"text":"Because the presence of catheter-associated blood stream infection is difficult to confirm, we","text_display":"\n\nBecause the presence of catheter-associated blood stream infection is difficult to confirm, we","confidence":1,"confidence_rate":1},{"cnt":[[245,1884],[1760,1884],[1760,1931],[245,1931]],"region":{"top_left_x":244,"top_left_y":1884,"width":1516,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b7ccaf9548d4648aed0c7f0f34f02b8","type":"text","conversion_output":true,"text":"are also including patients who do not have a catheter, as well as patients who do have a","text_display":" are also including patients who do not have a catheter, as well as patients who do have a","confidence":1,"confidence_rate":1},{"cnt":[[245,1934],[1850,1934],[1850,1981],[245,1981]],"region":{"top_left_x":244,"top_left_y":1933,"width":1606,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"292366e1d4a04c4dbddf5e1f7d76c3f1","type":"text","conversion_output":true,"text":"catheter and in whom this infection is suspected clinically, but confirmation is not possible. The","text_display":" catheter and in whom this infection is suspected clinically, but confirmation is not possible. The","confidence":1,"confidence_rate":1},{"cnt":[[245,1985],[1841,1985],[1841,2030],[245,2030]],"region":{"top_left_x":244,"top_left_y":1985,"width":1598,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3ac17c6787548b2907c3e4a5f42c737","type":"text","conversion_output":true,"text":"inclusion of patients with suspected catheter-associated staphylococcal blood stream infection","text_display":" inclusion of patients with suspected catheter-associated staphylococcal blood stream infection","confidence":1,"confidence_rate":1},{"cnt":[[245,2035],[1721,2035],[1721,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2034,"width":1477,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"049c9fe484aa4b8ea3f728ae725dcc5a","type":"text","conversion_output":true,"text":"serves two important purposes. First, it avoids the prohibitively high screen:enroll ratios","text_display":" serves two important purposes. First, it avoids the prohibitively high screen:enroll ratios","confidence":1,"confidence_rate":1},{"cnt":[[245,2084],[1871,2084],[1871,2133],[245,2133]],"region":{"top_left_x":244,"top_left_y":2083,"width":1628,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"068563b5eaa4418aa92db6c5d9e007cb","type":"text","conversion_output":true,"text":"experienced by recent clinical trials requiring confirmed infection \\({ }^{27,28}\\). Second, it strengthens the","text_display":" experienced by recent clinical trials requiring confirmed infection \\({ }^{27,28}\\). Second, it strengthens the","confidence":1,"confidence_rate":1},{"cnt":[[245,2136],[1863,2136],[1863,2185],[245,2185]],"region":{"top_left_x":244,"top_left_y":2135,"width":1619,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0fb435b8bb34424b3a511de0241304d","type":"text","conversion_output":true,"text":"clinical relevance of this study by better reflecting current clinical practice. In this way, the study","text_display":" clinical relevance of this study by better reflecting current clinical practice. 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any type of intravascular catheter, including peripheral catheters,","confidence":1,"confidence_rate":1},{"cnt":[[245,2329],[1781,2329],[1781,2374],[245,2374]],"region":{"top_left_x":244,"top_left_y":2328,"width":1538,"height":47},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13be5f16009e46e383dbb0c3cea2a660","type":"text","conversion_output":true,"text":"peripherally-inserted central catheters (PICC); central venous catheters (short-term central","text_display":" peripherally-inserted central catheters (PICC); central venous catheters (short-term central","confidence":1,"confidence_rate":1},{"cnt":[[245,2376],[1841,2376],[1841,2426],[245,2426]],"region":{"top_left_x":244,"top_left_y":2376,"width":1598,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70c91bba64144e9ab4d85e08993aa640","type":"text","conversion_output":true,"text":"venous catheters, vascath); cuffed, tunneled central lines (eg, Perm-cath, Hickman catheters),","text_display":" venous catheters, vascath); cuffed, tunneled central lines (eg, Perm-cath, Hickman catheters),","confidence":1,"confidence_rate":1},{"cnt":[[245,2428],[801,2428],[801,2477],[245,2477]],"region":{"top_left_x":244,"top_left_y":2427,"width":558,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9720f45b1c504ee0969f534681f531d7","type":"text","conversion_output":true,"text":"and peripheral arterial catheters.","text_display":" and peripheral arterial catheters.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2593],[1038,2593]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":38},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a3200362d2e14e818f090b429555182a","type":"page_info","conversion_output":false,"text":"26","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-041","page":41,"lines":[{"cnt":[[245,198],[1059,198],[1059,238],[245,238]],"region":{"top_left_x":244,"top_left_y":197,"width":816,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"77af9efa913e4c61bab4ca78268b7105","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,200],[1878,200],[1878,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":199,"width":168,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f62d3f0ef60d4ce0aa259971517ecdb6","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1878,236],[1878,269],[1603,269]],"region":{"top_left_x":1602,"top_left_y":236,"width":276,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1510a2049ac94f959c6164c3622a4eae","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[247,309],[1824,309],[1824,354],[247,354]],"region":{"top_left_x":247,"top_left_y":309,"width":1578,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8a23d442ba94ed7b515475c64706b7d","type":"text","conversion_output":true,"text":"Confirmed catheter-associated staphylococcal blood stream infection will be defined as","text_display":"\n\nConfirmed catheter-associated staphylococcal blood stream infection will be defined as","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[245,357],[1858,357],[1858,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1615,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa0321eb1d9b40aa84d2e36e509c5fbb","type":"text","conversion_output":true,"text":"the isolation of staphylococci in a patient with 1 ) \"an intravascular device and \\(\\geq 1\\) positive blood","text_display":" the isolation of staphylococci in a patient with 1 ) \"an intravascular device and \\(\\geq 1\\) positive blood","confidence":0.9159134132787585,"confidence_rate":0.9992018328344262},{"cnt":[[245,408],[1824,408],[1824,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":1581,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2d07efc0b9d4451aaa871fdeb8487b2","type":"text","conversion_output":true,"text":"culture of blood samples obtained from the peripheral vein, clinical manifestations of infection","text_display":" culture of blood samples obtained from the peripheral vein, clinical manifestations of infection","confidence":1,"confidence_rate":1},{"cnt":[[245,460],[1846,460],[1846,507],[245,507]],"region":{"top_left_x":244,"top_left_y":459,"width":1602,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d1463b1fe484ae4ab1fe90af962dfd5","type":"text","conversion_output":true,"text":"(e.g., fever, chills, and/or hypotension), and no apparent source for bloodstream infection (with","text_display":" (e.g., fever, chills, and/or hypotension), and no apparent source for bloodstream infection (with","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[245,507],[1699,507],[1699,556],[245,556]],"region":{"top_left_x":244,"top_left_y":507,"width":1456,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d554866828342a6880d19c9c1620c96","type":"text","conversion_output":true,"text":"the exception of the catheter); and 2 ) at least one of the following: \"a positive result of","text_display":" the exception of the catheter); and 2 ) at least one of the following: \"a positive result of","confidence":0.6603294960223138,"confidence_rate":0.9958584367050997},{"cnt":[[245,559],[1708,559],[1708,608],[245,608]],"region":{"top_left_x":244,"top_left_y":558,"width":1465,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"344c036be5454192be8bb0eb0d1bc581","type":"text","conversion_output":true,"text":"semiquantitative (> 15 colony forming units [cfu] per catheter segment) or quantitative","text_display":" semiquantitative (> 15 colony forming units [cfu] per catheter segment) or quantitative","confidence":0.5078125,"confidence_rate":0.9928922959152123},{"cnt":[[245,610],[1803,610],[1803,660],[245,660]],"region":{"top_left_x":244,"top_left_y":610,"width":1559,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9758b13e099a4fde9dece7b020fe2115","type":"text","conversion_output":true,"text":"( \\(>10^{2}\\) cfu per catheter segment) catheter culture, whereby the same organism (species and","text_display":" ( \\(>10^{2}\\) cfu per catheter segment) catheter culture, whereby the same organism (species and","confidence":0.8350412845611572,"confidence_rate":0.9982680965482086},{"cnt":[[245,660],[1841,660],[1841,707],[245,707]],"region":{"top_left_x":244,"top_left_y":659,"width":1598,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65c2f1e6e9534c8b9afb1834973271bb","type":"text","conversion_output":true,"text":"antibiogram) is isolated from a catheter segment and a peripheral blood sample; simultaneous","text_display":" antibiogram) is isolated from a catheter segment and a peripheral blood sample; simultaneous","confidence":1,"confidence_rate":1},{"cnt":[[245,709],[1809,709],[1809,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1565,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4550e184be0f421f9a4f9a17de37f93e","type":"text","conversion_output":true,"text":"quantitative cultures of blood samples with a ratio of \\(>5: 1\\) (central venous catheter [CVC] vs","text_display":" quantitative cultures of blood samples with a ratio of \\(>5: 1\\) (central venous catheter [CVC] 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}^{20}\\)","text_display":" obtained at least 2 hours earlier than is a positive result of culture from peripheral blood). \\({ }^{20}\\)","confidence":1,"confidence_rate":1},{"cnt":[[247,902],[1826,902],[1826,950],[247,950]],"region":{"top_left_x":247,"top_left_y":902,"width":1580,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1dbf1b93e80c450fb98ff7bef65c1025","type":"text","conversion_output":true,"text":"Suspected catheter-associated staphylococcal blood stream infection will be defined as","text_display":"\n\nSuspected catheter-associated staphylococcal blood stream infection will be defined as","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[245,952],[1854,952],[1854,999],[245,999]],"region":{"top_left_x":244,"top_left_y":951,"width":1611,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"675eca2698fc46858975d2ce6607c2d4","type":"text","conversion_output":true,"text":"the isolation of staphylococci in a patient with an intravascular device, or a patient who has had","text_display":" the isolation of staphylococci in a patient with an intravascular device, or a patient who has had","confidence":1,"confidence_rate":1},{"cnt":[[245,1001],[1738,1001],[1738,1051],[245,1051]],"region":{"top_left_x":244,"top_left_y":1001,"width":1495,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d045ed668fb6482fa9e2a1f84d39a9f5","type":"text","conversion_output":true,"text":"an intravascular device removed within 5 days of initial blood culture drawn, and clinical","text_display":" an intravascular device removed within 5 days of initial blood culture drawn, and clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1053],[1766,1053],[1766,1102],[245,1102]],"region":{"top_left_x":244,"top_left_y":1052,"width":1523,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9528550c0caa4b649aca0e07db383083","type":"text","conversion_output":true,"text":"suspicion of catheter-associated infection, but without any quantitative or semiquantitative","text_display":" suspicion of catheter-associated infection, but without any quantitative or 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settings,","confidence":1,"confidence_rate":1},{"cnt":[[245,1381],[1867,1381],[1867,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1381,"width":1623,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3e06bda678f45feb8213401dbaf847c","type":"text","conversion_output":true,"text":"including those that are nosocomial, non-nosocomial but health care-associated, and those that","text_display":" including those that are nosocomial, non-nosocomial but health care-associated, and those that","confidence":1,"confidence_rate":1},{"cnt":[[245,1431],[1824,1431],[1824,1480],[245,1480]],"region":{"top_left_x":244,"top_left_y":1430,"width":1581,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28f2af312f084f9b8bc900b8a6323266","type":"text","conversion_output":true,"text":"are community-acquired. In accordance with accepted practice \\({ }^{32}\\), these terms are defined as","text_display":" are community-acquired. In accordance with accepted practice \\({ }^{32}\\), these terms are defined as","confidence":1,"confidence_rate":1},{"cnt":[[245,1482],[380,1482],[380,1523],[245,1523]],"region":{"top_left_x":244,"top_left_y":1482,"width":137,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ae90a1f5d8649a38b6a001c54cfeff6","type":"text","conversion_output":true,"text":"follows:","text_display":" follows:","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1861,1573],[1861,1622],[245,1622]],"region":{"top_left_x":244,"top_left_y":1572,"width":1617,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"339f6c4fa63b4f78ad8af11e2a734e60","type":"text","conversion_output":true,"text":"Nosocomial bloodstream infection will be defined as a positive blood culture obtained from a","text_display":"\n\nNosocomial bloodstream infection will be defined as a positive blood culture obtained from a","confidence":1,"confidence_rate":1},{"cnt":[[245,1624],[1865,1624],[1865,1674],[245,1674]],"region":{"top_left_x":244,"top_left_y":1624,"width":1621,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64c5d5d9fc5946d8b61753df2f27ce19","type":"text","conversion_output":true,"text":"patient who has been hospitalized for 48 hours or longer. 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Toxicity to","confidence":1,"confidence_rate":1},{"cnt":[[245,1040],[1755,1040],[1755,1089],[245,1089]],"region":{"top_left_x":244,"top_left_y":1039,"width":1512,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2dfa17e566234783971b7802f128c3f1","type":"text","conversion_output":true,"text":"vancomycin intravenous will be monitored by performing hematology and chemistry tests","text_display":" vancomycin intravenous will be monitored by performing hematology and chemistry tests","confidence":1,"confidence_rate":1},{"cnt":[[245,1089],[1742,1089],[1742,1139],[245,1139]],"region":{"top_left_x":244,"top_left_y":1089,"width":1499,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f21f2311359e45dd9c794868d084c99b","type":"text","conversion_output":true,"text":"outlined in Section 8.15, and as clinically indicated to conform to published guidelines. \\({ }^{33}\\)","text_display":" outlined in Section 8.15, and as clinically indicated to conform to published guidelines. \\({ }^{33}\\)","confidence":1,"confidence_rate":1},{"cnt":[[241,1177],[1227,1177],[1227,1240],[241,1240]],"region":{"top_left_x":240,"top_left_y":1177,"width":987,"height":63},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9e7639dcd7a42579e1d078da4f93887","type":"section_header","conversion_output":false,"children_ids":["cbf103be195648e4a6f77640c9e6f9f0"],"text":"","text_display":""},{"cnt":[[245,1182],[1222,1182],[1222,1235],[245,1235]],"region":{"top_left_x":244,"top_left_y":1181,"width":979,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbf103be195648e4a6f77640c9e6f9f0","type":"text","conversion_output":true,"parent_id":"f9e7639dcd7a42579e1d078da4f93887","text":"6.1.2 Alternatives to Intravenous Vancomycin","text_display":"\n\n\\subsection*{6.1.2 Alternatives to Intravenous Vancomycin}","confidence":1,"confidence_rate":1},{"cnt":[[247,1250],[1729,1250],[1729,1298],[247,1298]],"region":{"top_left_x":247,"top_left_y":1250,"width":1483,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a211f4f63a74d9c95e7d34336249a37","type":"text","conversion_output":true,"text":"In the appropriate clinical settings, vancomycin alternative agents that are commercially","text_display":"\n\nIn the appropriate clinical settings, vancomycin alternative agents that are commercially","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[245,1298],[1622,1298],[1622,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1297,"width":1379,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbeadcccb58b46daa2d0b8a78c0d45f0","type":"text","conversion_output":true,"text":"available, approved by the study protocol, and FDA-approved for US sites and/or","text_display":" available, approved by the study protocol, and FDA-approved for US sites and/or","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[1820,1341],[1820,1386],[245,1386]],"region":{"top_left_x":244,"top_left_y":1340,"width":1576,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15e19f033ab3434d87bdc4342cc7a2b9","type":"text","conversion_output":true,"text":"EMEA-approved for the site in Spain will also be acceptable for use in the algorithm arm. For","text_display":" EMEA-approved for the site in Spain will also be acceptable for use in the algorithm arm. For","confidence":1,"confidence_rate":1},{"cnt":[[245,1384],[1742,1384],[1742,1429],[245,1429]],"region":{"top_left_x":244,"top_left_y":1383,"width":1499,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d0eaf03bbbc42018eed7bf74f0c4cb9","type":"text","conversion_output":true,"text":"patients in the SOC arm, the primary provider has unrestricted choice of antibiotics. It is","text_display":" patients in the SOC arm, the primary provider has unrestricted choice of antibiotics. It is","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[1863,1427],[1863,1474],[245,1474]],"region":{"top_left_x":244,"top_left_y":1426,"width":1619,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55ee8e0dee154635b8c2f28a0344142c","type":"text","conversion_output":true,"text":"preferable that all patients be treated with vancomycin. However, vancomycin alternatives may","text_display":" preferable that all patients be treated with vancomycin. However, vancomycin alternatives may","confidence":1,"confidence_rate":1},{"cnt":[[245,1472],[1803,1472],[1803,1519],[245,1519]],"region":{"top_left_x":244,"top_left_y":1471,"width":1559,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48f67a095f96447382103b3db7fedd62","type":"text","conversion_output":true,"text":"be used if the bloodstream staphylococcal isolate is methicillin-susceptible, if the isolate has","text_display":" be used if the bloodstream staphylococcal isolate is methicillin-susceptible, if the isolate has","confidence":1,"confidence_rate":1},{"cnt":[[245,1517],[1841,1517],[1841,1562],[245,1562]],"region":{"top_left_x":244,"top_left_y":1516,"width":1598,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e071f9b4ea647f4aea5a0508150eb9c","type":"text","conversion_output":true,"text":"reduced susceptibility to vancomycin, or if the patient develops, or has an existing, intolerance","text_display":" reduced susceptibility to vancomycin, or if the patient develops, or has an existing, intolerance","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1833,1560],[1833,1605],[245,1605]],"region":{"top_left_x":244,"top_left_y":1559,"width":1589,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7941983848bc4511af6a331b4187693e","type":"text","conversion_output":true,"text":"or allergy to vancomycin, as outlined below. In addition, any antibiotic may be utilized in SOC","text_display":" or allergy to vancomycin, as outlined below. In addition, any antibiotic may be utilized in SOC","confidence":1,"confidence_rate":1},{"cnt":[[245,1603],[1115,1603],[1115,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1602,"width":872,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5db77e2e245141d989d90a90d981ead0","type":"text","conversion_output":true,"text":"patients in order to follow standard clinical practice.","text_display":" patients in order to follow standard clinical practice.","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1467,1689],[1467,1738],[245,1738]],"region":{"top_left_x":244,"top_left_y":1688,"width":1224,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f363662cae342e2af38cae924d0fe50","type":"text","conversion_output":true,"text":"Appropriate settings for vancomycin alternatives include the following:","text_display":"\n\nAppropriate settings for vancomycin alternatives include the following:","confidence":0.9990234375,"confidence_rate":0.9999871442977954},{"cnt":[[370,1783],[1783,1783],[1783,1833],[370,1833]],"region":{"top_left_x":369,"top_left_y":1783,"width":1415,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66754f5dfe53400c8d7df95db8e5f8e4","type":"text","conversion_output":true,"text":"- Replacement of vancomycin with intravenous antistaphylococcal penicillin (e.g.,","text_display":"\n- Replacement of vancomycin with intravenous antistaphylococcal penicillin (e.g.,","confidence":1,"confidence_rate":1},{"cnt":[[434,1833],[1833,1833],[1833,1880],[434,1880]],"region":{"top_left_x":433,"top_left_y":1832,"width":1400,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a940d3a8ccac47a5868aad48d435d605","type":"text","conversion_output":true,"text":"penicillin, nafcillin, oxacillin, cloxacillin) or first generation cephalosporin (cefazolin)","text_display":" penicillin, nafcillin, oxacillin, cloxacillin) or first generation cephalosporin (cefazolin)","confidence":1,"confidence_rate":1},{"cnt":[[434,1882],[1532,1882],[1532,1931],[434,1931]],"region":{"top_left_x":433,"top_left_y":1882,"width":1099,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b7964c3de0a4db3a485187f767d29c6","type":"text","conversion_output":true,"text":"for patients with methicillin susceptible staphylococcal infections.","text_display":" for patients with methicillin susceptible staphylococcal infections.","confidence":0.99853515625,"confidence_rate":0.9999799191374794},{"cnt":[[369,1977],[1867,1974],[1867,2024],[370,2026]],"region":{"top_left_x":369,"top_left_y":1974,"width":1499,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e22ab45cec104980ba4dad7d2594ac7d","type":"text","conversion_output":true,"text":"- Use of daptomycin (US) or Cubicin (Spain) (dosed per standard of care in patients in","text_display":"\n- Use of daptomycin (US) or Cubicin (Spain) (dosed per standard of care in patients in","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[432,2028],[1854,2028],[1854,2073],[432,2073]],"region":{"top_left_x":431,"top_left_y":2028,"width":1424,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edb70e35ea5a44f19bdfcd11daeb9d75","type":"text","conversion_output":true,"text":"the SOC arm and at \\(6 mg / kg\\) IV once daily, or according to patient renal function per","text_display":" the SOC arm and at \\(6 mg / kg\\) IV once daily, or according to patient renal function per","confidence":0.9892628192901611,"confidence_rate":0.9998887150564895},{"cnt":[[434,2075],[1699,2075],[1699,2125],[434,2125]],"region":{"top_left_x":433,"top_left_y":2075,"width":1267,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf3c9f61788e4712924b0be6f73c5892","type":"text","conversion_output":true,"text":"package insert, for patients in the algorithm arm) when methicillin-resistant","text_display":" package insert, for patients in the algorithm arm) when methicillin-resistant","confidence":1,"confidence_rate":1},{"cnt":[[434,2127],[1841,2127],[1841,2176],[434,2176]],"region":{"top_left_x":433,"top_left_y":2126,"width":1409,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54c5e07d4d914491810db144a16acec3","type":"text","conversion_output":true,"text":"staphylococcal bloodstream infection has been identified and if vancomycin cannot","text_display":" staphylococcal bloodstream infection has been identified and if vancomycin cannot","confidence":1,"confidence_rate":1},{"cnt":[[434,2179],[1766,2179],[1766,2226],[434,2226]],"region":{"top_left_x":433,"top_left_y":2178,"width":1334,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"387f27f4406b44fb97cf935c09c7c007","type":"text","conversion_output":true,"text":"be used due to the development of vancomycin allergy or intolerance, reduced","text_display":" be used due to the development of vancomycin allergy or intolerance, reduced","confidence":0.99658203125,"confidence_rate":0.9999577314692709},{"cnt":[[432,2228],[1747,2228],[1747,2275],[432,2275]],"region":{"top_left_x":431,"top_left_y":2227,"width":1316,"height":49},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4394775c590142a9ab225947372af9ea","type":"text","conversion_output":true,"text":"vancomycin susceptibility (vancomycin MIC \\(\\geq 2 \\mu g / ml\\) for S. aureus), AE/SAE","text_display":" vancomycin susceptibility (vancomycin MIC \\(\\geq 2 \\mu g / ml\\) for S. aureus), AE/SAE","confidence":0.8410525143563063,"confidence_rate":0.9979892199346231},{"cnt":[[434,2277],[1794,2277],[1794,2327],[434,2327]],"region":{"top_left_x":433,"top_left_y":2277,"width":1361,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8b18eb39af14a2b850124e2bb050fcd","type":"text","conversion_output":true,"text":"potentially related to vancomycin, or other extenuating circumstances that would","text_display":" potentially related to vancomycin, or other extenuating circumstances that would","confidence":1,"confidence_rate":1},{"cnt":[[434,2329],[1755,2329],[1755,2374],[434,2374]],"region":{"top_left_x":433,"top_left_y":2328,"width":1323,"height":47},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c11a5aad116c455d8675e4c845124b5a","type":"text","conversion_output":true,"text":"require withdrawal of the patient from the trial (these circumstances should be","text_display":" require withdrawal of the patient from the trial (these circumstances should be","confidence":1,"confidence_rate":1},{"cnt":[[434,2378],[1828,2378],[1828,2426],[434,2426]],"region":{"top_left_x":433,"top_left_y":2378,"width":1396,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcafc07056fe41878fda753c3203cfe7","type":"text","conversion_output":true,"text":"discussed with the Clinical Medical Monitor who will subsequently discuss with the","text_display":" discussed with the Clinical Medical Monitor who will subsequently discuss with 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Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,202],[1878,202],[1878,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":201,"width":168,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"75f64572d51e4dbe9441d65691ff4664","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1605,236],[1880,236],[1880,269],[1605,269]],"region":{"top_left_x":1604,"top_left_y":236,"width":276,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"037dc604eeda4c10b778ee46211e0174","type":"page_info","conversion_output":false,"text":"05 November 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Setting*","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,511],[1970,511],[1970,1717],[245,1717]],"region":{"top_left_x":244,"top_left_y":511,"width":1727,"height":1206},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11eb50568a3d4888b1933e67f9e88f68","type":"table","conversion_output":true,"children_ids":["5ced573292cd4fb58ac816f2cd7856e0","3a355392de2b4c8e80cde4539d0ebebd","69b1adb83bed4186a35a3a4fcad2f3b2","8f66e76a1a4746a79a3d9d9a278b563e","c444ff54890a4e18977466a0415bf43f","189f732270e640d88d79d5b81b525a0f","a758e1d1a23440289c77c9e6d98201cb","9b304dfe0510407c88935d8d89893c20","271abc14337642a0819996f2a53a5024","7060d1d7846a4152a2d854aba2fb1e25","782557b98655416c8abfd26f1b4f7f9c","0f56f303a5a74b4ca0ec57cf7128be85","32e84976ad7d4167b8d554188a61b295","146a1391203b4b468792be880add0a8e","c1554b0cddff481a8a71caccda55c1dd","d9dc53254fab4e5391051d002624e582","4c76e05c2f1d465193cea77764b1540c","439f7a73e25345ffae7a08b562f7dc8d","e376a8a0fdb142cfa4b44280cd7bb38c","57672b7046fb4cb29b10f1dfacaff950"],"selected_labels":["8f6a5b4afd8a4e74aaf293a76a27cb97"],"text":"\\begin{tabular}{|l|l|l|}\n\\hline Antibiotic & Dosing & Comments \\\\\n\\hline \\multicolumn{3}{|l|}{Vancomycin alternative antibiotics for methicillin susceptible staphylococci} \\\\\n\\hline US - Nafcillin, oxacillin Spain - Cloxacillin & 2 gm q 4 h IV , or equivalent dosing through continuous infusion, in algorithm arm (dosing per SOC in SOC arm) & \\multirow{2}{*}{Preferred agents for MSSA and susceptible CoNS. If penicillin-allergic or intolerant, may use vancomycin instead} \\\\\n\\hline Penicillin & 4 million units q4h IV or equivalent dosing through continuous infusion, in algorithm arm (dosing per SOC in SOC arm) & \\\\\n\\hline Cefazolin & 1.5 gm q 6h IV or equivalent, e.g. 2 gm q 8h IV**, renally doseadjusted per package insert & In the US, may use for S. aureus only, per FDA indication. In Spain, may use for any methicillin-susceptible staphylococci \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2: Vancomycin Alternatives by Clinical Setting*}\n\\begin{tabular}{|l|l|l|}\n\\hline Antibiotic & Dosing & Comments \\\\\n\\hline \\multicolumn{3}{|l|}{Vancomycin alternative antibiotics for methicillin susceptible staphylococci} \\\\\n\\hline US - Nafcillin, oxacillin Spain - Cloxacillin & 2 gm q 4 h IV , or equivalent dosing through continuous infusion, in algorithm arm (dosing per SOC in SOC arm) & \\multirow{2}{*}{Preferred agents for MSSA and susceptible CoNS. 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In Spain, may use for any methicillin-susceptible staphylococci","text_display":"In the US, may use for S. aureus only, per FDA indication. In Spain, may use for any methicillin-susceptible staphylococci","cell_row":4,"cell_column":2,"cell_row_span":1,"cell_col_span":1,"confidence":1,"confidence_rate":1},{"cnt":[[1270,1460],[1922,1460],[1922,1507],[1270,1507]],"region":{"top_left_x":1269,"top_left_y":1460,"width":653,"height":47},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"365d4449cfa14ee98c765e1efca1eef3","type":"text","conversion_output":false,"parent_id":"57672b7046fb4cb29b10f1dfacaff950","text":"In the US, may use for S. aureus only,","text_display":"In the US, may use for S. aureus only,","confidence":1,"confidence_rate":1},{"cnt":[[1270,1510],[1927,1510],[1927,1561],[1270,1561]],"region":{"top_left_x":1269,"top_left_y":1509,"width":659,"height":53},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b980df9d49a34215b55257b8ba86bba4","type":"text","conversion_output":false,"parent_id":"57672b7046fb4cb29b10f1dfacaff950","text":"per FDA indication. In Spain, may use","text_display":" per FDA indication. 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arm)\n\\end{tabular} & \\begin{tabular}{l} \nUse only if unable to give vancomycin \\\\\ndue to allergy, intolerance, elevated \\\\\nvancomycin MIC, or AE/SAE\n\\end{tabular} \\\\\nSpain - Cubicin &\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Vancomycin alternative antibiotics for methicillin resistant staphylococci}\n\\begin{tabular}{|l|l|l|}\n\\hline US - Daptomycin*** & \\begin{tabular}{l}\n\\(6 mg / kg\\) IV q 24 h in \\\\\nalgorithm arm (dosing \\\\\nper SOC in SOC arm)\n\\end{tabular} & \\begin{tabular}{l} \nUse only if unable to give vancomycin \\\\\ndue to allergy, intolerance, elevated \\\\\nvancomycin MIC, or AE/SAE\n\\end{tabular} \\\\\nSpain - Cubicin &\n\\end{tabular}\n\\end{table}","confidence":0.39054847992987923,"confidence_rate":0.9967962584314075},{"cnt":[[245,1989],[1618,1989],[1618,2035],[245,2035]],"region":{"top_left_x":244,"top_left_y":1989,"width":1374,"height":46},"line":59,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0421fb391e3249668fb6ca61e7cc6f0a","type":"text","conversion_output":true,"text":"*any antibiotic may be utilized in SOC patients in order to follow standard clinical practice","text_display":"\n*any antibiotic may be utilized in SOC patients in order to follow standard clinical practice","confidence":0.9721813201904297,"confidence_rate":0.999712154205828},{"cnt":[[245,2030],[1772,2030],[1772,2073],[245,2073]],"region":{"top_left_x":244,"top_left_y":2030,"width":1529,"height":44},"line":60,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31a461c86b95434f8295001b566cb3c4","type":"text","conversion_output":true,"text":"**recommended dose per package insert is \\(1-1.5 g\\) q 6 h IV, which is equivalent to the 2 gm q 8 h IV","text_display":" **recommended dose per package insert is \\(1-1.5 g\\) q 6 h IV, which is equivalent to the 2 gm q 8 h IV","confidence":0.4676706771657646,"confidence_rate":0.9938897847882111},{"cnt":[[245,2071],[1807,2071],[1807,2116],[245,2116]],"region":{"top_left_x":244,"top_left_y":2071,"width":1563,"height":46},"line":61,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"390b179b58b24f22ae92039b06b56656","type":"text","conversion_output":true,"text":"recommended by current guidelines, and less than the \\(12 g /\\) day maximum dose allowed per package","text_display":" recommended by current guidelines, and less than the \\(12 g /\\) day maximum dose allowed per 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Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,200],[1878,200],[1878,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":199,"width":168,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8d8f1b1167304bf8bd469cfa9471009c","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1880,236],[1880,269],[1603,269]],"region":{"top_left_x":1602,"top_left_y":236,"width":278,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5919935b10244453b4b7e458ff97e879","type":"page_info","conversion_output":false,"text":"05 November 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Antibiotics}","confidence":0.99951171875,"confidence_rate":0.9999847376009057},{"cnt":[[245,475],[1878,475],[1878,526],[245,526]],"region":{"top_left_x":244,"top_left_y":474,"width":1634,"height":53},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4a8e9563d60b49aca5063a93fb9b3809","type":"text","conversion_output":true,"text":"All vancomycin alternatives will be considered in calculating antibiotic days. In the event that two","text_display":"\n\nAll vancomycin alternatives will be considered in calculating antibiotic days. In the event that two","confidence":1,"confidence_rate":1},{"cnt":[[245,526],[1835,526],[1835,576],[245,576]],"region":{"top_left_x":244,"top_left_y":526,"width":1591,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f91ed8e4da0140b79ea545cb08c55ea7","type":"text","conversion_output":true,"text":"antibiotics are used in empiric treatment of presumed staphylococcal sepsis, when both drugs","text_display":" antibiotics are used in empiric treatment of presumed staphylococcal sepsis, when both drugs","confidence":1,"confidence_rate":1},{"cnt":[[245,576],[1747,576],[1747,625],[245,625]],"region":{"top_left_x":244,"top_left_y":575,"width":1503,"height":51},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eeea9248460b46bfb4fa7078fc2dbc93","type":"text","conversion_output":true,"text":"are administered concomitantly only the duration of vancomycin will be considered when","text_display":" are administered concomitantly only the duration of vancomycin will be considered when","confidence":1,"confidence_rate":1},{"cnt":[[245,625],[1863,625],[1863,677],[245,677]],"region":{"top_left_x":244,"top_left_y":625,"width":1619,"height":52},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"790a90e5d4934b38b8b9b6aaa79802dc","type":"text","conversion_output":true,"text":"calculating antibiotic days. In the rare event that two antibiotics are administered concomitantly","text_display":" calculating antibiotic days. In the rare event that two antibiotics are administered concomitantly","confidence":1,"confidence_rate":1},{"cnt":[[245,675],[1824,675],[1824,724],[245,724]],"region":{"top_left_x":244,"top_left_y":674,"width":1581,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"411dfbf68e784fadb04b49cde92ccb02","type":"text","conversion_output":true,"text":"and neither is vancomycin, the effective antistaphylococcal antibiotic will be considered when","text_display":" and neither is vancomycin, the effective antistaphylococcal antibiotic will be considered when","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[1863,726],[1863,776],[245,776]],"region":{"top_left_x":244,"top_left_y":726,"width":1619,"height":50},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c36c78b103cc47779ab62338bb53cbbf","type":"text","conversion_output":true,"text":"calculating antibiotic days (per Section 6.3.1 use of combination antistaphylococcal treatment is","text_display":" calculating antibiotic days (per Section 6.3.1 use of combination antistaphylococcal treatment is","confidence":1,"confidence_rate":1},{"cnt":[[245,778],[1772,778],[1772,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1529,"height":51},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"50e5631be9534771bc49bcd6d162cf66","type":"text","conversion_output":true,"text":"not permitted in either treatment group). In the event that two antibiotics with documented","text_display":" not permitted in either treatment group). In the event that two antibiotics with documented","confidence":1,"confidence_rate":1},{"cnt":[[245,827],[1809,827],[1809,879],[245,879]],"region":{"top_left_x":244,"top_left_y":827,"width":1565,"height":52},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12f6eb88150f4c72a99b861eb911e64d","type":"text","conversion_output":true,"text":"efficacy based on the susceptibility profile of the bloodstream isolate are added sequentially,","text_display":" efficacy based on the susceptibility profile of the bloodstream isolate are added sequentially,","confidence":1,"confidence_rate":1},{"cnt":[[245,877],[1843,877],[1843,926],[245,926]],"region":{"top_left_x":244,"top_left_y":876,"width":1600,"height":50},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d651bc06c208443799a130cd63a1c00c","type":"text","conversion_output":true,"text":"including as part of empiric therapy, the total duration of effective antistaphylococcal treatment","text_display":" including as part of empiric therapy, the total duration of effective antistaphylococcal treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,928],[1128,928],[1128,975],[245,975]],"region":{"top_left_x":244,"top_left_y":928,"width":884,"height":48},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f5e9547331a4a8a9779cd41db00758f","type":"text","conversion_output":true,"text":"with one or more agent will be used for calculations.","text_display":" with one or more agent will be used for calculations.","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[1721,1018],[1721,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1018,"width":1477,"height":50},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad0246309858418faec70b44400a861d","type":"text","conversion_output":true,"text":"The following sections clarify durations of antibiotics for algorithm-treated patients only.","text_display":"\n\nThe following sections clarify durations of antibiotics for algorithm-treated patients only.","confidence":1,"confidence_rate":1},{"cnt":[[245,1070],[1820,1070],[1820,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1069,"width":1576,"height":51},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8335feb1f4654c02b65ea34eed80d2a3","type":"text","conversion_output":true,"text":"Patients in the SOC treatment arm will be managed according to the judgment of the primary","text_display":" Patients in the SOC treatment arm will be managed according to the judgment of the primary","confidence":0.96435546875,"confidence_rate":0.9996180170916952},{"cnt":[[245,1119],[1863,1119],[1863,1171],[245,1171]],"region":{"top_left_x":244,"top_left_y":1119,"width":1619,"height":52},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6f513257b6e413fafd2d880865b348f","type":"text","conversion_output":true,"text":"treating physician. If patients were given empiric treatment prior to speciation and susceptibility","text_display":" treating physician. If patients were given empiric treatment prior to speciation and susceptibility","confidence":1,"confidence_rate":1},{"cnt":[[245,1169],[1732,1169],[1732,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1168,"width":1488,"height":51},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87c378996d994f7ab21a42840a7f4308","type":"text","conversion_output":true,"text":"testing and the empiric treatment was found not to be effective for the baseline infecting","text_display":" testing and the empiric treatment was found not to be effective for the baseline infecting","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1811,1220],[1811,1270],[245,1270]],"region":{"top_left_x":244,"top_left_y":1220,"width":1568,"height":50},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d6a1e57ebdf54d68bf7054dc167fbd41","type":"text","conversion_output":true,"text":"pathogen, those days will not be counted towards duration of treatment or as antibiotic days.","text_display":" pathogen, those days will not be counted towards duration of treatment or as antibiotic days.","confidence":1,"confidence_rate":1},{"cnt":[[245,1268],[1704,1268],[1704,1319],[245,1319]],"region":{"top_left_x":244,"top_left_y":1267,"width":1460,"height":53},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12bf9c8d760c45539e24b3d72b96d621","type":"text","conversion_output":true,"text":"Similarly, if patients were given oral prophylaxis with antibiotics for at least 7 days and","text_display":" Similarly, if patients were given oral prophylaxis with antibiotics for at least 7 days and","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,1319],[1824,1319],[1824,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":1581,"height":50},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a8f4983eada45faa565502ec248612d","type":"text","conversion_output":true,"text":"developed the index bacteremia regardless, these oral antibiotics will not be counted towards","text_display":" developed the index bacteremia regardless, these oral antibiotics will not be counted towards","confidence":1,"confidence_rate":1},{"cnt":[[245,1371],[883,1371],[883,1420],[245,1420]],"region":{"top_left_x":244,"top_left_y":1370,"width":640,"height":51},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"143287ff97874dd2af5c9ef4ef8b71a0","type":"text","conversion_output":true,"text":"antibiotic days prior to randomization.","text_display":" antibiotic days prior to randomization.","confidence":1,"confidence_rate":1},{"cnt":[[241,1457],[1162,1457],[1162,1521],[241,1521]],"region":{"top_left_x":240,"top_left_y":1456,"width":923,"height":66},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1cd913abec94f579e89d7b59b11cd78","type":"section_header","conversion_output":false,"children_ids":["d152d231e6594442b12b49ef7315184b"],"text":"","text_display":""},{"cnt":[[245,1461],[1156,1461],[1156,1515],[245,1515]],"region":{"top_left_x":244,"top_left_y":1460,"width":912,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d152d231e6594442b12b49ef7315184b","type":"text","conversion_output":true,"parent_id":"e1cd913abec94f579e89d7b59b11cd78","text":"6.2.1 Coagulase Negative Staphylococcus","text_display":"\n\n\\subsection*{6.2.1 Coagulase Negative Staphylococcus}","confidence":1,"confidence_rate":1},{"cnt":[[245,1551],[1764,1551],[1764,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1551,"width":1520,"height":50},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"10d650bbf0a5445eb4d302544adbe7e4","type":"text","conversion_output":true,"text":"Patients randomized to Algorithm-based treatment will be treated according to the type of","text_display":"\n\nPatients randomized to Algorithm-based treatment will be treated according to the type of","confidence":1,"confidence_rate":1},{"cnt":[[245,1603],[1867,1603],[1867,1652],[245,1652]],"region":{"top_left_x":244,"top_left_y":1602,"width":1623,"height":51},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"547c3c69bfe6423a9947ada3c85b92ba","type":"text","conversion_output":true,"text":"staphylococcal infection present. Patients with CoNS blood stream infection will be categorized","text_display":" staphylococcal infection present. Patients with CoNS blood stream infection will be categorized","confidence":1,"confidence_rate":1},{"cnt":[[245,1652],[1798,1652],[1798,1699],[245,1699]],"region":{"top_left_x":244,"top_left_y":1652,"width":1555,"height":48},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e40def2b4d6495ba2f05442e76426a0","type":"text","conversion_output":true,"text":"into simple or Uncomplicated treatment groups. In some cases, complicated staphylococcal","text_display":" into simple or Uncomplicated treatment groups. In some cases, complicated staphylococcal","confidence":1,"confidence_rate":1},{"cnt":[[245,1702],[1749,1702],[1749,1751],[245,1751]],"region":{"top_left_x":244,"top_left_y":1701,"width":1505,"height":50},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ea5f53988454e65b216f622548eee3a","type":"text","conversion_output":true,"text":"infections may develop after randomization in patients with CoNS blood stream infection.","text_display":" infections may develop after randomization in patients with CoNS blood stream infection.","confidence":0.998046875,"confidence_rate":0.9999789783410032},{"cnt":[[245,1753],[1734,1753],[1734,1803],[245,1803]],"region":{"top_left_x":244,"top_left_y":1753,"width":1490,"height":50},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"72164495bdb1429e837fc49d13ad4b87","type":"text","conversion_output":true,"text":"Simple: Patients randomized to Algorithm-based treatment who meet criteria for simple","text_display":" Simple: Patients randomized to Algorithm-based treatment who meet criteria for simple","confidence":1,"confidence_rate":1},{"cnt":[[245,1800],[1796,1800],[1796,1852],[245,1852]],"region":{"top_left_x":244,"top_left_y":1800,"width":1553,"height":52},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87987ba9e466461fabe6f96a6346e12b","type":"text","conversion_output":true,"text":"coagulase negative staphylococcal blood stream infection (as defined in Table 1) may have","text_display":" coagulase negative staphylococcal blood stream infection (as defined in Table 1) may have","confidence":1,"confidence_rate":1},{"cnt":[[245,1852],[1790,1852],[1790,1901],[245,1901]],"region":{"top_left_x":244,"top_left_y":1851,"width":1546,"height":51},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46d01a387f07407fa15b74669cd10c64","type":"text","conversion_output":true,"text":"received up to \\(3(+1)\\) calendar days of vancomycin, or protocol approved alternative. Upon","text_display":" received up to \\(3(+1)\\) calendar days of vancomycin, or protocol approved alternative. Upon","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1803,1904],[1803,1953],[245,1953]],"region":{"top_left_x":244,"top_left_y":1903,"width":1559,"height":50},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbbb728ad29a4b24a94153fb287902ea","type":"text","conversion_output":true,"text":"randomization to Algorithm-based treatment, antibiotic treatment for the index bacteremia in","text_display":" randomization to Algorithm-based treatment, antibiotic treatment for the index bacteremia in","confidence":1,"confidence_rate":1},{"cnt":[[245,1953],[1729,1953],[1729,2000],[245,2000]],"region":{"top_left_x":244,"top_left_y":1952,"width":1486,"height":49},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4441fddeb85c471aa5a2bcc7dc2bc590","type":"text","conversion_output":true,"text":"patients who meet criteria for simple CoNS must be discontinued. If the patient has not","text_display":" patients who meet criteria for simple CoNS must be discontinued. If the patient has not","confidence":1,"confidence_rate":1},{"cnt":[[245,2002],[1841,2002],[1841,2052],[245,2052]],"region":{"top_left_x":244,"top_left_y":2002,"width":1598,"height":50},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6447baa6ceb84266a2395593f1937e30","type":"text","conversion_output":true,"text":"received any antibiotic treatment for the index bacteremia prior to randomization, no treatment","text_display":" received any antibiotic treatment for the index bacteremia prior to randomization, no treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,2054],[1727,2054],[1727,2103],[245,2103]],"region":{"top_left_x":244,"top_left_y":2053,"width":1484,"height":51},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d803e114b704a98b0f62c5ad208655a","type":"text","conversion_output":true,"text":"will be started. In the simple CoNS algorithm patients who do not receive any antibiotic","text_display":" will be started. In the simple CoNS algorithm patients who do not receive any antibiotic","confidence":1,"confidence_rate":1},{"cnt":[[245,2103],[1699,2103],[1699,2151],[245,2151]],"region":{"top_left_x":244,"top_left_y":2103,"width":1456,"height":48},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9faabf5350e04181b2dd9e36202cc6e1","type":"text","conversion_output":true,"text":"treatment, End Of Therapy will be defined as the day that the patient was randomized","text_display":" treatment, End Of Therapy will be defined as the day that the patient was randomized","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1772,2196],[1772,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":1529,"height":51},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e01f3ada8b43402c8efa2ae33bb53063","type":"text","conversion_output":true,"text":"Uncomplicated: Algorithm patients meeting criteria for uncomplicated CoNS blood stream","text_display":"\n\nUncomplicated: Algorithm patients meeting criteria for uncomplicated CoNS blood stream","confidence":1,"confidence_rate":1},{"cnt":[[245,2245],[1828,2245],[1828,2295],[245,2295]],"region":{"top_left_x":244,"top_left_y":2245,"width":1585,"height":50},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53d31e1c97dd454898b031c86636464e","type":"text","conversion_output":true,"text":"infection (as defined in Table 1) will receive \\(5(-/+1)\\) calendar days of vancomycin or protocol-","text_display":" infection (as defined in Table 1) will receive \\(5(-/+1)\\) calendar days of vancomycin or protocol","confidence":0.9975595474243164,"confidence_rate":0.9999762776082356},{"cnt":[[245,2295],[1283,2295],[1283,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2294,"width":1039,"height":50},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"58360371d7a54745bcaad06fa0efac7c","type":"text","conversion_output":true,"text":"approved vancomycin alternative as defined in Section 6.1.2.","text_display":"approved vancomycin alternative as defined in Section 6.1.2.","confidence":0.998046875,"confidence_rate":0.9999699229933099},{"cnt":[[245,2385],[1830,2385],[1830,2436],[245,2436]],"region":{"top_left_x":244,"top_left_y":2384,"width":1587,"height":53},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"173b5edb3c244351bb05b34bf11610c0","type":"text","conversion_output":true,"text":"Complicated: Algorithm patients who develop complicated CoNS blood stream infection after","text_display":"\n\nComplicated: Algorithm patients who develop complicated CoNS blood stream infection after","confidence":1,"confidence_rate":1},{"cnt":[[245,2436],[1869,2436],[1869,2486],[245,2486]],"region":{"top_left_x":244,"top_left_y":2436,"width":1626,"height":50},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70e43eefc5bc4aa8bfdd10301c740e7e","type":"text","conversion_output":true,"text":"randomization but before the completion of study treatment for their baseline bacteremia clinical","text_display":" randomization but before the completion of study treatment for their baseline bacteremia clinical","confidence":1,"confidence_rate":1},{"cnt":[[1038,2557],[1089,2557],[1089,2595],[1038,2595]],"region":{"top_left_x":1037,"top_left_y":2556,"width":53,"height":40},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"19649aa00f3e4048871927e9b6ecc160","type":"page_info","conversion_output":false,"text":"32","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-047","page":47,"lines":[{"cnt":[[245,200],[1059,200],[1059,238],[245,238]],"region":{"top_left_x":244,"top_left_y":199,"width":816,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cd247963a7f4fbc84e804b829f25b64","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,200],[1878,200],[1878,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":199,"width":168,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d97eef30f114c03881e89aaf2900d75","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1880,236],[1880,269],[1603,269]],"region":{"top_left_x":1602,"top_left_y":236,"width":278,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ad7f7e3c3ca4cb3953dc41311745c41","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,309],[1841,309],[1841,357],[245,357]],"region":{"top_left_x":244,"top_left_y":309,"width":1598,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c316b13d4294b3881abab4800dd70c6","type":"text","conversion_output":true,"text":"classification (i.e. Simple CoNS, Uncomplicated CoNS) will receive 7-28 (-/+2) calendar days","text_display":"\nclassification (i.e. Simple CoNS, Uncomplicated CoNS) will receive 7-28 (-/+2) calendar days","confidence":0.7914702663231139,"confidence_rate":0.997591945607352},{"cnt":[[245,357],[1798,357],[1798,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1555,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00ab8d41db5b46c088b275a59db5bee0","type":"text","conversion_output":true,"text":"of treatment with vancomycin or a protocol-approved vancomycin alternative antibiotic. This","text_display":" of treatment with vancomycin or a protocol-approved vancomycin alternative antibiotic. This","confidence":1,"confidence_rate":1},{"cnt":[[245,408],[1858,408],[1858,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":1615,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06a3dffc6710445993d8c1358d1031aa","type":"text","conversion_output":true,"text":"wide range of possible treatment durations reflects the heterogeneity of complicated coagulase","text_display":" wide range of possible treatment durations reflects the heterogeneity of complicated coagulase","confidence":1,"confidence_rate":1},{"cnt":[[245,460],[1863,460],[1863,507],[245,507]],"region":{"top_left_x":244,"top_left_y":459,"width":1619,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a19fc738ec5b4fceafcf4957668174dd","type":"text","conversion_output":true,"text":"negative staphylococcal infections. For example, a patient with CoNS blood stream infection on","text_display":" negative staphylococcal infections. For example, a patient with CoNS blood stream infection on","confidence":1,"confidence_rate":1},{"cnt":[[245,507],[1852,507],[1852,556],[245,556]],"region":{"top_left_x":244,"top_left_y":507,"width":1608,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6e2f441347d49f9887f705d26317fc4","type":"text","conversion_output":true,"text":"2 separate calendar days but without signs of metastatic infection may be treated for as few as","text_display":" 2 separate calendar days but without signs of metastatic infection may be treated for as few as","confidence":0.99951171875,"confidence_rate":0.9999950666738041},{"cnt":[[245,559],[1852,559],[1852,608],[245,608]],"region":{"top_left_x":244,"top_left_y":558,"width":1608,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0c0e5980d744909925564630175666a","type":"text","conversion_output":true,"text":"7 days, whereas endocarditis would be treated for up to 28 days. Precise duration of treatment","text_display":" 7 days, whereas endocarditis would be treated for up to 28 days. 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As with coagulase negative staphylococcal infections, there is","text_display":" as defined in Section 6.1.2. 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Refer to Schedule of","confidence":0.9697265625,"confidence_rate":0.9996659129765211},{"cnt":[[245,1680],[1278,1680],[1278,1725],[245,1725]],"region":{"top_left_x":244,"top_left_y":1680,"width":1035,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfdb46f355434efea8839d7a6c21aacf","type":"text","conversion_output":true,"text":"Events sections 8.7, 8.8 and 8.10 for Enrollment procedures.","text_display":" Events sections 8.7, 8.8 and 8.10 for Enrollment procedures.","confidence":0.99853515625,"confidence_rate":0.9999793534852197},{"cnt":[[243,1792],[986,1792],[986,1850],[243,1850]],"region":{"top_left_x":242,"top_left_y":1791,"width":745,"height":59},"line":28,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"34f8c49969dd4ebebc51411e4019f379","type":"section_header","conversion_output":false,"children_ids":["3c4e28557adf4eedbc891971d4903683"],"text":"","text_display":""},{"cnt":[[245,1796],[982,1796],[982,1846],[245,1846]],"region":{"top_left_x":244,"top_left_y":1796,"width":738,"height":50},"line":29,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"3c4e28557adf4eedbc891971d4903683","type":"text","conversion_output":true,"parent_id":"34f8c49969dd4ebebc51411e4019f379","text":"7.4 Schedule of Assessments","text_display":"\n\n\\subsection*{7.4 Schedule of Assessments}","confidence":1,"confidence_rate":1},{"cnt":[[254,1856],[1850,1856],[1850,1904],[254,1904]],"region":{"top_left_x":253,"top_left_y":1856,"width":1597,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce0ef6e8ade440d99ca5152cd4eef11d","type":"text","conversion_output":true,"text":"For patients assigned to algorithm-based treatment and the standard of care-based treatment,","text_display":"\n\nFor patients assigned to algorithm-based treatment and the standard of care-based treatment,","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1837,1904],[1837,1953],[245,1953]],"region":{"top_left_x":244,"top_left_y":1903,"width":1593,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d91a2c7d009b42b1b4392708300926ab","type":"text","conversion_output":true,"text":"the Schedule of Events tables are provided in Sections 8.7 through 8.11. 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Patients readmitted before final TOC","text_display":" should notify study staff of the reason for readmission. 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Definitions of the different categories are listed in Table 1.","confidence":0.99951171875,"confidence_rate":0.9999941857252588},{"cnt":[[1038,2552],[1089,2552],[1089,2600],[1038,2600]],"region":{"top_left_x":1037,"top_left_y":2552,"width":53,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5ff2b94ad0f146329d337e183ae55c05","type":"page_info","conversion_output":false,"text":"39","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-054","page":54,"lines":[{"cnt":[[245,198],[1059,198],[1059,238],[245,238]],"region":{"top_left_x":244,"top_left_y":197,"width":816,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e1e747e97454a4fb69364aa8c177d35","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,202],[1878,202],[1878,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":201,"width":168,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bee3fbbf695b41a0b6547d8962e474a4","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1880,236],[1880,271],[1603,271]],"region":{"top_left_x":1602,"top_left_y":236,"width":278,"height":35},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e906b23c452449539889b61ac8c3b00e","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[241,421],[1025,421],[1025,477],[241,477]],"region":{"top_left_x":240,"top_left_y":421,"width":785,"height":56},"line":4,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"17d73bc2f73341ebad59a742120f18c8","type":"section_header","conversion_output":false,"children_ids":["413bac2f702e4d93a4a2c24877cbcf96"],"text":"","text_display":""},{"cnt":[[245,425],[1021,425],[1021,473],[245,473]],"region":{"top_left_x":244,"top_left_y":425,"width":777,"height":48},"line":5,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"413bac2f702e4d93a4a2c24877cbcf96","type":"text","conversion_output":true,"parent_id":"17d73bc2f73341ebad59a742120f18c8","text":"8.2 Standard of Care Treatment","text_display":"\n\n\\subsection*{8.2 Standard of Care Treatment}","confidence":1,"confidence_rate":1},{"cnt":[[247,486],[1867,486],[1867,531],[247,531]],"region":{"top_left_x":247,"top_left_y":485,"width":1620,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"056504c9a90c4b3fbbf36dbe12ca397b","type":"text","conversion_output":true,"text":"For the purposes of this trial, Standard of Care treatment will consist of routine care as provided","text_display":"\n\nFor the purposes of this trial, Standard of Care treatment will consist of routine care as provided","confidence":0.9951171875,"confidence_rate":0.9999529359885383},{"cnt":[[245,537],[1824,537],[1824,582],[245,582]],"region":{"top_left_x":244,"top_left_y":537,"width":1581,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fd4779b2d314ab0ae8dcfc1f9593afa","type":"text","conversion_output":true,"text":"by the patient's primary provider. Therefore there will not be a mandatory treatment regimen,","text_display":" by the patient's primary provider. Therefore there will not be a mandatory treatment regimen,","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,587],[1708,587],[1708,634],[245,634]],"region":{"top_left_x":244,"top_left_y":586,"width":1465,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a510e39437204cb4a8cc03550f8a05c4","type":"text","conversion_output":true,"text":"such as that advocated by the IDSA guidelines. The goal in this trial is not to compare","text_display":" such as that advocated by the IDSA guidelines. The goal in this trial is not to compare","confidence":1,"confidence_rate":1},{"cnt":[[245,636],[1841,636],[1841,683],[245,683]],"region":{"top_left_x":244,"top_left_y":635,"width":1598,"height":49},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b976b3c120e2414cb48ab305cdaaf676","type":"text","conversion_output":true,"text":"algorithm-based care to published guidelines (which are in any event often not followed \\({ }^{44}\\) ), as","text_display":" algorithm-based care to published guidelines (which are in any event often not followed \\({ }^{44}\\) ), as","confidence":1,"confidence_rate":1},{"cnt":[[245,687],[1721,687],[1721,733],[245,733]],"region":{"top_left_x":244,"top_left_y":687,"width":1477,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67f5bd9cf72e44a6aaa92baa409f3237","type":"text","conversion_output":true,"text":"the algorithm-based recommendations mimic the guideline recommendation by design.","text_display":" the algorithm-based recommendations mimic the guideline recommendation by design.","confidence":1,"confidence_rate":1},{"cnt":[[245,735],[1863,735],[1863,784],[245,784]],"region":{"top_left_x":244,"top_left_y":734,"width":1619,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f99fda95af7d43caa3972b65fe94e1f4","type":"text","conversion_output":true,"text":"Instead, the goal of this trial is to compare algorithm-based care to routine care as it is currently","text_display":" Instead, the goal of this trial is to compare algorithm-based care to routine care as it is currently","confidence":1,"confidence_rate":1},{"cnt":[[245,786],[1760,786],[1760,834],[245,834]],"region":{"top_left_x":244,"top_left_y":786,"width":1516,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37f75217a9b24095b1eb9689e1d1b5af","type":"text","conversion_output":true,"text":"practiced. Thus, for example, a patient in the SOC group may or may not have treatment","text_display":" practiced. Thus, for example, a patient in the SOC group may or may not have treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,838],[1828,838],[1828,883],[245,883]],"region":{"top_left_x":244,"top_left_y":837,"width":1585,"height":47},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5483204c69374872b6fa5232a5af08ce","type":"text","conversion_output":true,"text":"guided by an infectious disease consultant. Additionally, for those patients in the SOC group,","text_display":" guided by an infectious disease consultant. 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In this way, the algorithm-based treatment strategy","text_display":" unnecessary antibiotics in these patients. 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1.","confidence":0.99951171875,"confidence_rate":0.9999819112562659},{"cnt":[[241,836],[1233,836],[1233,902],[241,902]],"region":{"top_left_x":240,"top_left_y":835,"width":994,"height":68},"line":11,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"8d567b8bffcb47a9bb2b1b11077864c1","type":"section_header","conversion_output":false,"children_ids":["bb35560379334a5cbc146f261bc8aa15"],"text":"","text_display":""},{"cnt":[[245,842],[1227,842],[1227,898],[245,898]],"region":{"top_left_x":244,"top_left_y":842,"width":983,"height":57},"line":12,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"bb35560379334a5cbc146f261bc8aa15","type":"text","conversion_output":true,"parent_id":"8d567b8bffcb47a9bb2b1b11077864c1","text":"8.3 Simple CoNS Blood Stream Infection","text_display":"\n\n\\subsection*{8.3 Simple CoNS Blood Stream Infection}","confidence":0.99951171875,"confidence_rate":0.9999886419133848},{"cnt":[[245,945],[1863,945],[1863,990],[245,990]],"region":{"top_left_x":244,"top_left_y":945,"width":1619,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ea3b67fc81444969101454c682d5346","type":"text","conversion_output":true,"text":"We anticipate that a significant portion of the blood cultures included in this group will represent","text_display":"\n\nWe anticipate that a significant portion of the blood cultures included in this group will represent","confidence":1,"confidence_rate":1},{"cnt":[[245,993],[1734,993],[1734,1042],[245,1042]],"region":{"top_left_x":244,"top_left_y":992,"width":1490,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e6da2ea080445e9b78e3872ebe0aced","type":"text","conversion_output":true,"text":"contaminants rather than clinically significant blood culture results. However, the clinical","text_display":" contaminants rather than clinically significant blood culture results. However, the clinical","confidence":1,"confidence_rate":1},{"cnt":[[245,1044],[1867,1044],[1867,1091],[245,1091]],"region":{"top_left_x":244,"top_left_y":1044,"width":1623,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8080e7bcc204442ab1ba5e6ebb275423","type":"text","conversion_output":true,"text":"interpretation of a blood culture result as a contaminant generally occurs \\(36-48\\) hours after the","text_display":" interpretation of a blood culture result as a contaminant generally occurs \\(36-48\\) hours after the","confidence":0.9975602623308077,"confidence_rate":0.9999765125962303},{"cnt":[[245,1096],[1852,1096],[1852,1141],[245,1141]],"region":{"top_left_x":244,"top_left_y":1095,"width":1608,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e9ef96d71ea46f6a1cc3cca1434b2e8","type":"text","conversion_output":true,"text":"initial blood culture was obtained, when Gram positive cocci in clusters have been isolated, but","text_display":" initial blood culture was obtained, when Gram positive cocci in clusters have been isolated, but","confidence":1,"confidence_rate":1},{"cnt":[[245,1145],[1790,1145],[1790,1192],[245,1192]],"region":{"top_left_x":244,"top_left_y":1145,"width":1546,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d152bb3da6e4832aec37213c709c415","type":"text","conversion_output":true,"text":"not yet speciated. During this period, many patients are treated with empiric vancomycin or","text_display":" not yet speciated. During this period, many patients are treated with empiric vancomycin or","confidence":1,"confidence_rate":1},{"cnt":[[245,1195],[1682,1195],[1682,1244],[245,1244]],"region":{"top_left_x":244,"top_left_y":1194,"width":1439,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"072829c11a634657922d0650ff255a6f","type":"text","conversion_output":true,"text":"other effective vancomycin alternative due to the adverse impact of delayed effective","text_display":" other effective vancomycin alternative due to the adverse impact of delayed effective","confidence":1,"confidence_rate":1},{"cnt":[[245,1244],[1830,1244],[1830,1291],[245,1291]],"region":{"top_left_x":244,"top_left_y":1243,"width":1587,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a0dc3f3ff46414b9495b8c332a5240a","type":"text","conversion_output":true,"text":"antimicrobial treatment on the outcome of patients with S. aureus bloodstream infection. \\({ }^{34}\\) To","text_display":" antimicrobial treatment on the outcome of patients with S. aureus bloodstream infection. \\({ }^{34}\\) To","confidence":0.998046875,"confidence_rate":0.9999820640614399},{"cnt":[[245,1296],[1790,1296],[1790,1343],[245,1343]],"region":{"top_left_x":244,"top_left_y":1295,"width":1546,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2b6a5c022dd4e60bceb44967125b553","type":"text","conversion_output":true,"text":"account for this clinical reality, our treatment algorithm has allowed for a range of treatment","text_display":" account for this clinical reality, our treatment algorithm has allowed for a range of treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1345],[1850,1345],[1850,1394],[245,1394]],"region":{"top_left_x":244,"top_left_y":1344,"width":1606,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c88595c4aa2a4b25b594b7dd45553f79","type":"text","conversion_output":true,"text":"days. If a patient has been taking study antibiotic empirically before enrollment in the trial, the","text_display":" days. If a patient has been taking study antibiotic empirically before enrollment in the trial, the","confidence":1,"confidence_rate":1},{"cnt":[[245,1396],[1858,1396],[1858,1446],[245,1446]],"region":{"top_left_x":244,"top_left_y":1396,"width":1615,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5693ac744404fbfbe26068e83096cc5","type":"text","conversion_output":true,"text":"number of treatment days will be counted beginning at the day that empirical treatment with an","text_display":" number of treatment days will be counted beginning at the day that empirical treatment with an","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[1843,1448],[1843,1493],[245,1493]],"region":{"top_left_x":244,"top_left_y":1448,"width":1600,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43e1f69227714cc6b16e007c09ea95de","type":"text","conversion_output":true,"text":"antibiotic effective for the baseline infecting pathogen was started, and no earlier than the time","text_display":" antibiotic effective for the baseline infecting pathogen was started, and no earlier than the time","confidence":1,"confidence_rate":1},{"cnt":[[245,1495],[1790,1495],[1790,1545],[245,1545]],"region":{"top_left_x":244,"top_left_y":1495,"width":1546,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf766ddae63441eab7cdf461ff6a1254","type":"text","conversion_output":true,"text":"bacteremia was suspected i.e. the day that the index blood culture was drawn. In this way,","text_display":" bacteremia was suspected i.e. the day that the index blood culture was drawn. In this way,","confidence":0.99365234375,"confidence_rate":0.9999329718435114},{"cnt":[[245,1547],[1858,1547],[1858,1594],[245,1594]],"region":{"top_left_x":244,"top_left_y":1546,"width":1615,"height":49},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e9234db89eb4ce78cd4482a297c4aab","type":"text","conversion_output":true,"text":"patients with simple CoNS blood stream infection randomized to the algorithm-based treatment","text_display":" patients with simple CoNS blood stream infection randomized to the algorithm-based treatment","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1858,1594],[1858,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":1615,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e707558c01214494878257ee0dfd7177","type":"text","conversion_output":true,"text":"arm will have antibiotics appropriately discontinued, while those for whom parenteral antibiotics","text_display":" arm will have antibiotics appropriately discontinued, while those for whom parenteral antibiotics","confidence":1,"confidence_rate":1},{"cnt":[[245,1646],[1876,1646],[1876,1695],[245,1695]],"region":{"top_left_x":244,"top_left_y":1645,"width":1632,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a15c6f645a57423d92bb0ef94ac8e958","type":"text","conversion_output":true,"text":"are appropriate will be treated accordingly. Importantly, this design avoids the counterproductive","text_display":" are appropriate will be treated accordingly. Importantly, this design avoids the counterproductive","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[245,1697],[1833,1697],[1833,1742],[245,1742]],"region":{"top_left_x":244,"top_left_y":1697,"width":1589,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"028f1cdc0b8246ccb5b73755b8213534","type":"text","conversion_output":true,"text":"scenario of recipients of algorithm-based treatment being mandated to receive antibiotics that","text_display":" scenario of recipients of algorithm-based treatment being mandated to receive antibiotics that","confidence":1,"confidence_rate":1},{"cnt":[[245,1747],[816,1747],[816,1794],[245,1794]],"region":{"top_left_x":244,"top_left_y":1746,"width":573,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2b5ff1666d749a5bfcfc9e3672ea148","type":"text","conversion_output":true,"text":"they would otherwise not receive.","text_display":" they would otherwise not receive.","confidence":1,"confidence_rate":1},{"cnt":[[243,1856],[1016,1856],[1016,1921],[243,1921]],"region":{"top_left_x":242,"top_left_y":1856,"width":775,"height":65},"line":30,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"85fe8abe66ce40949911989463345b90","type":"section_header","conversion_output":false,"children_ids":["e1a49f21f26644e591a7cc9dcd22813b"],"text":"","text_display":""},{"cnt":[[245,1861],[1012,1861],[1012,1919],[245,1919]],"region":{"top_left_x":244,"top_left_y":1860,"width":768,"height":59},"line":31,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"e1a49f21f26644e591a7cc9dcd22813b","type":"text","conversion_output":true,"parent_id":"85fe8abe66ce40949911989463345b90","text":"8.4 Further Speciation of CoNS","text_display":"\n\n\\subsection*{8.4 Further Speciation of CoNS}","confidence":0.99951171875,"confidence_rate":0.9999860457974148},{"cnt":[[245,1964],[1848,1964],[1848,2013],[245,2013]],"region":{"top_left_x":244,"top_left_y":1963,"width":1604,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2acccf9efe6f496fa0c2ab0fa90f838d","type":"text","conversion_output":true,"text":"The decision to treat CoNS isolated from the blood stream can be influenced by the species of","text_display":"\n\nThe decision to treat CoNS isolated from the blood stream can be influenced by the species of","confidence":1,"confidence_rate":1},{"cnt":[[245,2015],[1850,2015],[1850,2065],[245,2065]],"region":{"top_left_x":244,"top_left_y":2015,"width":1606,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33c8b3b8628540239655a7c480ccdc22","type":"text","conversion_output":true,"text":"the organism. For example, the isolation of Staphylococcus lugdunensis from the blood stream","text_display":" the organism. For example, the isolation of Staphylococcus lugdunensis from the blood stream","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[245,2065],[1878,2065],[1878,2112],[245,2112]],"region":{"top_left_x":244,"top_left_y":2064,"width":1634,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"682839bbd1d04252850a545c911d62f4","type":"text","conversion_output":true,"text":"is virtually always clinically significant and requires treatment \\({ }^{34}\\). However, the cost-effectiveness","text_display":" is virtually always clinically significant and requires treatment \\({ }^{34}\\). However, the cost-effectiveness","confidence":1,"confidence_rate":1},{"cnt":[[245,2114],[1852,2114],[1852,2163],[245,2163]],"region":{"top_left_x":244,"top_left_y":2114,"width":1608,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ac6d2d47bdf4a2ba18d8308de42612e","type":"text","conversion_output":true,"text":"of routine speciation of CoNS from blood cultures is controversial, and thus CoNS speciation is","text_display":" of routine speciation of CoNS from blood cultures is controversial, and thus CoNS speciation is","confidence":1,"confidence_rate":1},{"cnt":[[245,2166],[1863,2166],[1863,2211],[245,2211]],"region":{"top_left_x":244,"top_left_y":2165,"width":1619,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df50679ff8fd4ce6a27ee2b2895ab2bd","type":"text","conversion_output":true,"text":"not performed at all medical centers. In the current trial, CoNS speciation is performed at some,","text_display":" not performed at all medical centers. In the current trial, CoNS speciation is performed at some,","confidence":1,"confidence_rate":1},{"cnt":[[245,2213],[1760,2213],[1760,2262],[245,2262]],"region":{"top_left_x":244,"top_left_y":2212,"width":1516,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ad276873159451cb86ecb0ca27ba836","type":"text","conversion_output":true,"text":"but not all participating sites. For this reason, CoNS speciation is preferred and should be","text_display":" but not all participating sites. For this reason, CoNS speciation is preferred and should be","confidence":1,"confidence_rate":1},{"cnt":[[245,2264],[1846,2264],[1846,2314],[245,2314]],"region":{"top_left_x":244,"top_left_y":2264,"width":1602,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3ad2bd997c64387877eb7770d90e1d3","type":"text","conversion_output":true,"text":"requested for enrolled subjects but is not mandated. However, susceptibility testing is required","text_display":" requested for enrolled subjects but is not mandated. However, susceptibility testing is required","confidence":1,"confidence_rate":1},{"cnt":[[245,2316],[1738,2316],[1738,2365],[245,2365]],"region":{"top_left_x":244,"top_left_y":2316,"width":1495,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed7e42f22d444f9d8eb691d86dc8191d","type":"text","conversion_output":true,"text":"for the baseline infection pathogen for all subjects, as this is critical for evaluating PENS","text_display":" for the baseline infection pathogen for all subjects, as this is critical for evaluating PENS","confidence":1,"confidence_rate":1},{"cnt":[[245,2368],[432,2368],[432,2408],[245,2408]],"region":{"top_left_x":244,"top_left_y":2367,"width":188,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d120eeadc97d40118507385bd6ae5191","type":"text","conversion_output":true,"text":"antibiotics.","text_display":" antibiotics.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2505],[1083,2505],[1083,2544],[1038,2544]],"region":{"top_left_x":1037,"top_left_y":2505,"width":46,"height":39},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f63853fbae44f8e92394b354fc33581","type":"page_info","conversion_output":false,"text":"41","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-056","page":56,"lines":[{"cnt":[[245,200],[1059,200],[1059,238],[245,238]],"region":{"top_left_x":244,"top_left_y":199,"width":816,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ed998307f7444ebc941ea66fe7f92201","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[1710,200],[1880,200],[1880,234],[1710,234]],"region":{"top_left_x":1710,"top_left_y":199,"width":170,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d69fa2ab929486d88ebc3cf61c80706","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,236],[1880,236],[1880,269],[1603,269]],"region":{"top_left_x":1602,"top_left_y":236,"width":278,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7013e05e172b4a469d673a955fe65983","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,309],[1865,309],[1865,354],[245,354]],"region":{"top_left_x":244,"top_left_y":309,"width":1621,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2837cb80588b46c2818cd3ec58e89aeb","type":"text","conversion_output":true,"text":"The interpretation of different species of staphylococci from different sets of blood cultures is an","text_display":"\n\nThe interpretation of different species of staphylococci from different sets of blood cultures is an","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[1794,357],[1794,406],[245,406]],"region":{"top_left_x":244,"top_left_y":356,"width":1550,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6f9c5cda85549749b010c953b323cde","type":"text","conversion_output":true,"text":"important consideration. Only the initial isolate in the discordant pairs will be considered as","text_display":" important consideration. Only the initial isolate in the discordant pairs will be considered as","confidence":1,"confidence_rate":1},{"cnt":[[245,408],[1809,408],[1809,458],[245,458]],"region":{"top_left_x":244,"top_left_y":408,"width":1565,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"667d5d5c4747439a9e9f7d59cad56f0c","type":"text","conversion_output":true,"text":"clinically significant except in the following circumstances: 1 ) at least one of the isolates is \\(S\\).","text_display":" clinically significant except in the following circumstances: 1 ) at least one of the isolates is \\(S\\).","confidence":0.7354877111937164,"confidence_rate":0.9972607100848163},{"cnt":[[245,460],[1783,460],[1783,505],[245,505]],"region":{"top_left_x":244,"top_left_y":459,"width":1540,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6766553947cf4fcb95a1562ddb0adfc9","type":"text","conversion_output":true,"text":"lugdunensis. In this situation, S. lugdunensis will be considered clinically significant; 2) one","text_display":" lugdunensis. In this situation, S. lugdunensis will be considered clinically significant; 2) one","confidence":0.9433897824492306,"confidence_rate":0.9994231789128974},{"cnt":[[245,509],[1871,509],[1871,556],[245,556]],"region":{"top_left_x":244,"top_left_y":509,"width":1628,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5f500efef9a4ea5bf11ab9b3bc844cf","type":"text","conversion_output":true,"text":"staphylococcal isolate is grown from a blood culture obtained from venipuncture and the second","text_display":" staphylococcal isolate is grown from a blood culture obtained from venipuncture and the second","confidence":1,"confidence_rate":1},{"cnt":[[245,559],[1785,559],[1785,606],[245,606]],"region":{"top_left_x":244,"top_left_y":558,"width":1542,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"536d329d55fe41af8fd4da1ed44b7c87","type":"text","conversion_output":true,"text":"staphylococcal isolate of a different species is grown from a blood culture obtained from an","text_display":" staphylococcal isolate of a different species is grown from a blood culture obtained from an","confidence":1,"confidence_rate":1},{"cnt":[[245,610],[1837,610],[1837,655],[245,655]],"region":{"top_left_x":244,"top_left_y":610,"width":1593,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6acc1c14833a4e88808269d6a521a101","type":"text","conversion_output":true,"text":"indwelling venous catheter. In this setting the peripheral culture will be considered as clinically","text_display":" indwelling venous catheter. In this setting the peripheral culture will be considered as clinically","confidence":1,"confidence_rate":1},{"cnt":[[245,660],[1818,660],[1818,707],[245,707]],"region":{"top_left_x":244,"top_left_y":659,"width":1574,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0ec41ef2ff54f09b0d7d59175f76069","type":"text","conversion_output":true,"text":"significant; 3) any other clinical setting which the site investigator and/or the patient's primary","text_display":" significant; 3) any other clinical setting which the site investigator and/or the patient's primary","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[245,709],[1663,709],[1663,758],[245,758]],"region":{"top_left_x":244,"top_left_y":708,"width":1419,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc6e37c25ce94c7da2a79a60165f9d73","type":"text","conversion_output":true,"text":"physician considers relevant in the determination of a clinically significant organism.","text_display":" physician considers relevant in the determination of a clinically significant organism.","confidence":0.998046875,"confidence_rate":0.9999787498471376},{"cnt":[[245,804],[1843,804],[1843,849],[245,849]],"region":{"top_left_x":244,"top_left_y":803,"width":1600,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78e36871fdf74231a0c6f4603cba638e","type":"text","conversion_output":true,"text":"In situations where S. aureus and at least one culture of CoNS staphylococci are isolated from","text_display":"\n\nIn situations where S. aureus and at least one culture of CoNS staphylococci are isolated from","confidence":0.96826171875,"confidence_rate":0.9996742666218359},{"cnt":[[245,851],[1648,851],[1648,900],[245,900]],"region":{"top_left_x":244,"top_left_y":850,"width":1404,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2a878bfc8094300a61160cdf24afeec","type":"text","conversion_output":true,"text":"two different sets of blood cultures, the patient will receive the \\(S\\). aureus treatment.","text_display":" two different sets of blood cultures, the patient will receive the \\(S\\). aureus treatment.","confidence":0.9311857223510742,"confidence_rate":0.9992576034768361},{"cnt":[[243,962],[816,962],[816,1027],[243,1027]],"region":{"top_left_x":242,"top_left_y":962,"width":575,"height":65},"line":15,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"3cc40eb7733f4c2f8ef4d23d80eefc48","type":"section_header","conversion_output":false,"children_ids":["bacaf50805ca44c79e277461e704e340"],"text":"","text_display":""},{"cnt":[[245,967],[814,967],[814,1025],[245,1025]],"region":{"top_left_x":244,"top_left_y":966,"width":571,"height":59},"line":16,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"bacaf50805ca44c79e277461e704e340","type":"text","conversion_output":true,"parent_id":"3cc40eb7733f4c2f8ef4d23d80eefc48","text":"8.5 Storage of Isolates","text_display":"\n\n\\subsection*{8.5 Storage of Isolates}","confidence":0.99755859375,"confidence_rate":0.9999127041197294},{"cnt":[[245,1070],[1732,1070],[1732,1119],[245,1119]],"region":{"top_left_x":244,"top_left_y":1069,"width":1488,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c812d0e231c47bba0795da3bbe8b450","type":"text","conversion_output":true,"text":"An important strength of this proposal is the planned storage of baseline staphylococcal","text_display":"\n\nAn important strength of this proposal is the planned storage of baseline staphylococcal","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1820,1121],[1820,1167],[245,1167]],"region":{"top_left_x":244,"top_left_y":1121,"width":1576,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a82935315cf41ed8300e06e8aca2a5e","type":"text","conversion_output":true,"text":"bloodstream isolates from patients enrolled in the trial who provided consent for future use of","text_display":" bloodstream isolates from patients enrolled in the trial who provided consent for future use of","confidence":0.99169921875,"confidence_rate":0.9999166492280784},{"cnt":[[245,1171],[1738,1171],[1738,1218],[245,1218]],"region":{"top_left_x":244,"top_left_y":1170,"width":1495,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce08b0029d8f49fa953ae1ffa226a11c","type":"text","conversion_output":true,"text":"their samples. These isolates will be saved, frozen at \\(-70^{\\circ} C\\) to \\(-80^{\\circ} C\\), and shipped to Dr.","text_display":" their samples. These isolates will be saved, frozen at \\(-70^{\\circ} C\\) to \\(-80^{\\circ} C\\), and shipped to Dr.","confidence":1,"confidence_rate":1},{"cnt":[[245,1220],[1876,1220],[1876,1268],[245,1268]],"region":{"top_left_x":244,"top_left_y":1220,"width":1632,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cc319091e884dfabf46926093f63d22","type":"text","conversion_output":true,"text":"Fowler's laboratory at Duke University. Alternatively, isolates may be lyophilized. The availability","text_display":" Fowler's laboratory at Duke University. Alternatively, isolates may be lyophilized. The availability","confidence":0.99560546875,"confidence_rate":0.9999580559693426},{"cnt":[[245,1272],[1798,1272],[1798,1317],[245,1317]],"region":{"top_left_x":244,"top_left_y":1271,"width":1555,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"930aaf1b493349cdb286a8396881a586","type":"text","conversion_output":true,"text":"of these isolates will allow for additional analyses (e.g., vancomycin MIC determination [see","text_display":" of these isolates will allow for additional analyses (e.g., vancomycin MIC determination [see","confidence":1,"confidence_rate":1},{"cnt":[[245,1319],[1818,1319],[1818,1369],[245,1369]],"region":{"top_left_x":244,"top_left_y":1319,"width":1574,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0063ba6b8aa14030a4339713fa9efa8f","type":"text","conversion_output":true,"text":"Section 8.6.1], genotyping, and pathogenesis studies). With the subject's (or LAR's) consent,","text_display":" Section 8.6.1], genotyping, and pathogenesis studies). With the subject's (or LAR's) consent,","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[245,1371],[1833,1371],[1833,1420],[245,1420]],"region":{"top_left_x":244,"top_left_y":1370,"width":1589,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c8a8ab69c80425792793a999269be2f","type":"text","conversion_output":true,"text":"subcultures of isolates may be sent from Dr. Fowler's laboratory to study Pls upon request for","text_display":" subcultures of isolates may be sent from Dr. Fowler's laboratory to study Pls upon request for","confidence":0.9970703125,"confidence_rate":0.9999703642024339},{"cnt":[[245,1422],[1858,1422],[1858,1467],[245,1467]],"region":{"top_left_x":244,"top_left_y":1422,"width":1615,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d323e83430d4e978855cb5ceb219b5b","type":"text","conversion_output":true,"text":"future testing. No human genetic testing will be performed as part of the current study or future","text_display":" future testing. No human genetic testing will be performed as part of the current study or future","confidence":1,"confidence_rate":1},{"cnt":[[245,1470],[1714,1470],[1714,1519],[245,1519]],"region":{"top_left_x":244,"top_left_y":1469,"width":1471,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edd5a451fbd14d2fb0db7c7fbf9482a3","type":"text","conversion_output":true,"text":"studies/testing. Dr. Fowler's laboratory personnel have extensive experience in linking","text_display":" studies/testing. Dr. Fowler's laboratory personnel have extensive experience in linking","confidence":1,"confidence_rate":1},{"cnt":[[245,1519],[1876,1519],[1876,1571],[245,1571]],"region":{"top_left_x":244,"top_left_y":1518,"width":1632,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46fd09014d41480cbeccb6b70b60ec18","type":"text","conversion_output":true,"text":"individual study data with bacterial isolates, \\({ }^{36,37,38,39}\\) as well as shipping and receipt of pathogens","text_display":" individual study data with bacterial isolates, \\({ }^{36,37,38,39}\\) as well as shipping and receipt of pathogens","confidence":1,"confidence_rate":1},{"cnt":[[245,1573],[1467,1573],[1467,1618],[245,1618]],"region":{"top_left_x":244,"top_left_y":1572,"width":1224,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7642d379c4a948ffbaae7bb0f1920aa3","type":"text","conversion_output":true,"text":"according to appropriate regulations. All shipments will be documented.","text_display":" according to appropriate regulations. All shipments will be documented.","confidence":1,"confidence_rate":1},{"cnt":[[245,1663],[1755,1663],[1755,1710],[245,1710]],"region":{"top_left_x":244,"top_left_y":1662,"width":1512,"height":49},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f60b4a31ca714a63953d8844d38e8f7c","type":"text","conversion_output":true,"text":"Isolates will be labeled with patient number and date of sample and stored at \\(-80^{\\circ} C\\) in Dr .","text_display":"\n\nIsolates will be labeled with patient number and date of sample and stored at \\(-80^{\\circ} C\\) in Dr .","confidence":0.7823700722074136,"confidence_rate":0.9978681242709794},{"cnt":[[245,1714],[1824,1714],[1824,1760],[245,1760]],"region":{"top_left_x":244,"top_left_y":1714,"width":1581,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2019be005ca74024b8529096cecd1c2c","type":"text","conversion_output":true,"text":"Fowler's laboratory until required for analysis. Additional details regarding collection, labeling,","text_display":" Fowler's laboratory until required for analysis. Additional details regarding collection, labeling,","confidence":1,"confidence_rate":1},{"cnt":[[245,1762],[1549,1762],[1549,1811],[245,1811]],"region":{"top_left_x":244,"top_left_y":1761,"width":1306,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cea1d46f73f34dc7abbb0f12bc88abc4","type":"text","conversion_output":true,"text":"and storage of isolates will be contained in the Manual of Procedures (MOP).","text_display":" and storage of isolates will be contained in the Manual of Procedures (MOP).","confidence":0.9990234375,"confidence_rate":0.9999879378548738},{"cnt":[[243,1852],[1485,1852],[1485,1912],[243,1912]],"region":{"top_left_x":242,"top_left_y":1851,"width":1243,"height":62},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7875533a86248828659c9a05d62cfd5","type":"section_header","conversion_output":false,"children_ids":["610249ff96ec4124baffa5ee4fd9f595"],"text":"","text_display":""},{"cnt":[[245,1856],[1480,1856],[1480,1910],[245,1910]],"region":{"top_left_x":244,"top_left_y":1856,"width":1237,"height":54},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"610249ff96ec4124baffa5ee4fd9f595","type":"text","conversion_output":true,"parent_id":"d7875533a86248828659c9a05d62cfd5","text":"8.5.1 Vancomycin Minimum Inhibitory Concentration (MIC)","text_display":"\n\n\\subsection*{8.5.1 Vancomycin Minimum Inhibitory Concentration (MIC)}","confidence":1,"confidence_rate":1},{"cnt":[[245,1946],[1732,1946],[1732,1992],[245,1992]],"region":{"top_left_x":244,"top_left_y":1946,"width":1488,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21005a77c4e74c48afc085c1487d21fd","type":"text","conversion_output":true,"text":"A growing body of evidence suggests that higher vancomycin MICs - even within levels","text_display":"\n\nA growing body of evidence suggests that higher vancomycin MICs - even within levels","confidence":1,"confidence_rate":1},{"cnt":[[245,1996],[1815,1996],[1815,2043],[245,2043]],"region":{"top_left_x":244,"top_left_y":1995,"width":1572,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5c41ce411004f84812dd6b24115c037","type":"text","conversion_output":true,"text":"interpreted as susceptible for staphylococci - in staphylococcal blood stream isolates may be","text_display":" interpreted as susceptible for staphylococci - in staphylococcal blood stream isolates may be","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[245,2045],[1841,2045],[1841,2093],[245,2093]],"region":{"top_left_x":244,"top_left_y":2045,"width":1598,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4a3fefd134b44d6b573afa287eef1ad","type":"text","conversion_output":true,"text":"associated with a worse overall clinical outcome. \\({ }^{40}\\) However, the clinical significance of these","text_display":" associated with a worse overall clinical outcome. \\({ }^{40}\\) However, the clinical significance of these","confidence":1,"confidence_rate":1},{"cnt":[[245,2093],[1753,2093],[1753,2142],[245,2142]],"region":{"top_left_x":244,"top_left_y":2092,"width":1510,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"148b2e3c7895412d876fb64e3524689e","type":"text","conversion_output":true,"text":"findings is not yet fully established. Thus, vancomycin MIC values are not routinely made","text_display":" findings is not yet fully established. Thus, vancomycin MIC values are not routinely made","confidence":1,"confidence_rate":1},{"cnt":[[245,2144],[1815,2144],[1815,2194],[245,2194]],"region":{"top_left_x":244,"top_left_y":2144,"width":1572,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28c1e9bdeb524baa868d3fb5133c8617","type":"text","conversion_output":true,"text":"clinically available at all of the participating sites in this trial. In order to uniformly address the","text_display":" clinically available at all of the participating sites in this trial. In order to uniformly address the","confidence":1,"confidence_rate":1},{"cnt":[[245,2196],[1850,2196],[1850,2245],[245,2245]],"region":{"top_left_x":244,"top_left_y":2195,"width":1606,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8e4ebff698b438f93eaa17c3f06b38a","type":"text","conversion_output":true,"text":"potential impact of bacterial vancomycin MIC values on the clinical outcome of patients treated","text_display":" potential impact of bacterial vancomycin MIC values on the clinical outcome of patients treated","confidence":1,"confidence_rate":1},{"cnt":[[245,2247],[1824,2247],[1824,2292],[245,2292]],"region":{"top_left_x":244,"top_left_y":2247,"width":1581,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09de7afdc73c426880e2fb1b73e410ea","type":"text","conversion_output":true,"text":"with this antibiotic, all baseline bloodstream isolates from enrolled patients will be retained by","text_display":" with this antibiotic, all baseline bloodstream isolates from enrolled patients will be retained by","confidence":1,"confidence_rate":1},{"cnt":[[245,2295],[1708,2295],[1708,2344],[245,2344]],"region":{"top_left_x":244,"top_left_y":2294,"width":1465,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f711e45a64714202855c91047bbf5cae","type":"text","conversion_output":true,"text":"the participating sites and shipped to Dr. Fowler's laboratory. Once in Dr. Fowler's lab,","text_display":" the participating sites and shipped to Dr. Fowler's laboratory. Once in Dr. Fowler's lab,","confidence":1,"confidence_rate":1},{"cnt":[[245,2346],[1721,2346],[1721,2393],[245,2393]],"region":{"top_left_x":244,"top_left_y":2346,"width":1477,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d9f8ca03dfa4031a75fb3f0fb2c7d55","type":"text","conversion_output":true,"text":"vancomycin MICs will be determined for all isolates using broth micro dilution methods.","text_display":" vancomycin MICs will be determined for all isolates using broth micro dilution methods.","confidence":1,"confidence_rate":1},{"cnt":[[1038,2505],[1089,2505],[1089,2544],[1038,2544]],"region":{"top_left_x":1037,"top_left_y":2505,"width":53,"height":39},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"438e978f10fc4a91b1c2317fb2f5c909","type":"page_info","conversion_output":false,"text":"42","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-057","page":57,"lines":[{"cnt":[[243,198],[1061,198],[1061,243],[243,243]],"region":{"top_left_x":242,"top_left_y":197,"width":820,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"87e7922a9c4148babafd6e54686f0fbe","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1710,198],[1880,198],[1880,236],[1710,236]],"region":{"top_left_x":1710,"top_left_y":197,"width":170,"height":40},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0169c83457844dfda2fbb5fe561ac91a","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1603,232],[1880,232],[1880,273],[1603,273]],"region":{"top_left_x":1602,"top_left_y":232,"width":278,"height":41},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ea7fa8a631b04274a2e4c17cebf495a3","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[245,305],[1751,305],[1751,359],[245,359]],"region":{"top_left_x":244,"top_left_y":305,"width":1507,"height":54},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"922119b2e59142169268955c6ed65323","type":"text","conversion_output":true,"text":"Potential associations between vancomycin MIC values and clinical outcome will then be","text_display":"\n\nPotential associations between vancomycin MIC values and clinical outcome will then be","confidence":1,"confidence_rate":1},{"cnt":[[245,357],[1104,357],[1104,408],[245,408]],"region":{"top_left_x":244,"top_left_y":356,"width":861,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e790c96da69d4e4f804c1384b14d03a8","type":"text","conversion_output":true,"text":"assessed as part of Exploratory Efficacy analyses.","text_display":" assessed as part of Exploratory Efficacy analyses.","confidence":1,"confidence_rate":1},{"cnt":[[236,464],[1235,464],[1235,539],[236,539]],"region":{"top_left_x":236,"top_left_y":464,"width":1000,"height":76},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de8305f1d77945b7a1c6639e97216b05","type":"section_header","conversion_output":false,"children_ids":["0de16680599a4bcba3d03d74fd3b9623"],"text":"","text_display":""},{"cnt":[[245,468],[1229,468],[1229,535],[245,535]],"region":{"top_left_x":244,"top_left_y":468,"width":985,"height":67},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0de16680599a4bcba3d03d74fd3b9623","type":"text","conversion_output":true,"parent_id":"de8305f1d77945b7a1c6639e97216b05","text":"8.6 Consideration of Vancomycin Levels","text_display":"\n\n\\subsection*{8.6 Consideration of Vancomycin Levels}","confidence":0.99951171875,"confidence_rate":0.9999886419133848},{"cnt":[[245,576],[1846,576],[1846,625],[245,625]],"region":{"top_left_x":244,"top_left_y":575,"width":1602,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bc2818c786b457daf73c18459c1d6f0","type":"text","conversion_output":true,"text":"In accordance with consensus guidelines published in 7/2009, vancomycin should be dosed to","text_display":"\n\nIn accordance with consensus guidelines published in 7/2009, vancomycin should be dosed to","confidence":0.99267578125,"confidence_rate":0.9999226222303292},{"cnt":[[245,623],[1861,623],[1861,677],[245,677]],"region":{"top_left_x":244,"top_left_y":623,"width":1617,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"221e5f3afe1f40f88612d1710fb5adc0","type":"text","conversion_output":true,"text":"attain target troughs of \\(15-20 mcg / ml .^{32}\\) Trough levels should be obtained just prior to the fourth","text_display":" attain target troughs of \\(15-20 mcg / ml .^{32}\\) Trough levels should be obtained just prior to the fourth","confidence":0.9854030609130859,"confidence_rate":0.9998753931656651},{"cnt":[[243,675],[1867,675],[1867,728],[243,728]],"region":{"top_left_x":242,"top_left_y":674,"width":1625,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f01478ebfb6142a5a3f1ea8d2fad3ad5","type":"text","conversion_output":true,"text":"dose, at steady-state conditions. However, in light of ongoing controversy regarding the efficacy","text_display":" dose, at steady-state conditions. 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In the simple CoNS algorithm patients who do not","confidence":1,"confidence_rate":1},{"cnt":[[434,713],[1777,713],[1777,752],[434,752]],"region":{"top_left_x":433,"top_left_y":713,"width":1344,"height":39},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0229b3416482424697b24d19692b6a14","type":"text","conversion_output":true,"text":"receive any antibiotic treatment for their index bacteremia, End Of Therapy will be defined","text_display":" receive any antibiotic treatment for their index bacteremia, End Of Therapy will be defined","confidence":0.91259765625,"confidence_rate":0.999047743489438},{"cnt":[[434,750],[1085,750],[1085,788],[434,788]],"region":{"top_left_x":433,"top_left_y":749,"width":652,"height":40},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"aaf367cf76114b95b8d6576e8a6a8bc2","type":"text","conversion_output":true,"text":"as the day that the patient was randomized.","text_display":" as the day that the patient was randomized.","confidence":1,"confidence_rate":1},{"cnt":[[370,786],[1766,786],[1766,823],[370,823]],"region":{"top_left_x":369,"top_left_y":786,"width":1398,"height":37},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e5e943a9499a414895beec4895734f14","type":"text","conversion_output":true,"text":"c. Test of Cure (TOC). If patients fail or are determined non-evaluable prior to the scheduled","text_display":"\nc. Test of Cure (TOC). If patients fail or are determined non-evaluable prior to the scheduled","confidence":1,"confidence_rate":1},{"cnt":[[434,821],[1766,821],[1766,862],[434,862]],"region":{"top_left_x":433,"top_left_y":820,"width":1334,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9596f23bdcc8478c93b63ff8acec1301","type":"text","conversion_output":true,"text":"TOC visit, all applicable final TOC assessments can be conducted at the time of failure or","text_display":" TOC visit, all applicable final TOC assessments can be conducted at the time of failure or","confidence":0.99755859375,"confidence_rate":0.9999742698958483},{"cnt":[[434,857],[1742,857],[1742,896],[434,896]],"region":{"top_left_x":433,"top_left_y":857,"width":1310,"height":39},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"351bad440923460a9e31deb5dd9800af","type":"text","conversion_output":true,"text":"non-evaluable determination and the patient can be classified as completing (failure) or","text_display":" non-evaluable determination and the patient can be classified as completing (failure) or","confidence":1,"confidence_rate":1},{"cnt":[[434,894],[1182,894],[1182,930],[434,930]],"region":{"top_left_x":433,"top_left_y":893,"width":749,"height":38},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9b3e1e02e7bc4b36acd0b5197e89b50a","type":"text","conversion_output":true,"text":"terminating (non-evaluable) the study at that time.","text_display":" terminating (non-evaluable) the study at that time.","confidence":1,"confidence_rate":1},{"cnt":[[370,928],[1738,928],[1738,969],[370,969]],"region":{"top_left_x":369,"top_left_y":928,"width":1370,"height":41},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3611a8432dea4ffca2bec520e641b841","type":"text","conversion_output":true,"text":"d. 14-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","text_display":"\nd. 14-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","confidence":0.9839081764221191,"confidence_rate":0.9998327696244723},{"cnt":[[434,971],[1783,971],[1783,1010],[434,1010]],"region":{"top_left_x":433,"top_left_y":971,"width":1351,"height":39},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e815d74bf9b421bb48d2b2fcc5950ba","type":"text","conversion_output":true,"text":"(required data obtained from the medical records is acceptable but not preferred). Perform","text_display":" (required data obtained from the medical records is acceptable but not preferred). Perform","confidence":1,"confidence_rate":1},{"cnt":[[434,1010],[750,1010],[750,1051],[434,1051]],"region":{"top_left_x":433,"top_left_y":1009,"width":317,"height":42},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0aaf7adc1c9641f0bac58573fb81d4a9","type":"text","conversion_output":true,"text":"PE only if clinic visit.","text_display":" PE only if clinic visit.","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[370,1053],[1738,1053],[1738,1094],[370,1094]],"region":{"top_left_x":369,"top_left_y":1052,"width":1370,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e01ec1d2e45a44c8b9bf1b551987116f","type":"text","conversion_output":true,"text":"e. 28-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","text_display":"\ne. 28-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","confidence":0.9737140475772321,"confidence_rate":0.9997254232279081},{"cnt":[[434,1091],[1794,1091],[1794,1132],[434,1132]],"region":{"top_left_x":433,"top_left_y":1091,"width":1361,"height":42},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6c239104fe794baaa9a02655ab4eda94","type":"text","conversion_output":true,"text":"(required data obtained from the medical records is acceptable but not preferred). Perform","text_display":" (required data obtained from the medical records is acceptable but not preferred). Perform","confidence":1,"confidence_rate":1},{"cnt":[[434,1134],[750,1134],[750,1173],[434,1173]],"region":{"top_left_x":433,"top_left_y":1134,"width":317,"height":40},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dc6c6018acd64f0a9e454955bb72efe2","type":"text","conversion_output":true,"text":"PE only if clinic visit.","text_display":" PE only if clinic visit.","confidence":1,"confidence_rate":1},{"cnt":[[370,1175],[1697,1175],[1697,1214],[370,1214]],"region":{"top_left_x":369,"top_left_y":1175,"width":1329,"height":39},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"994e9239e8864df9b67777f95d41e367","type":"text","conversion_output":true,"text":"f. Vital signs are blood pressure, heart rate and temperature; record the most clinically","text_display":"\nf. Vital signs are blood pressure, heart rate and temperature; record the most clinically","confidence":1,"confidence_rate":1},{"cnt":[[434,1212],[1008,1212],[1008,1248],[434,1248]],"region":{"top_left_x":433,"top_left_y":1211,"width":575,"height":38},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"906dc062625a4986b0ff65706d7f9c36","type":"text","conversion_output":true,"text":"significant measurement for that date.","text_display":" significant measurement for that date.","confidence":1,"confidence_rate":1},{"cnt":[[370,1248],[1811,1248],[1811,1287],[370,1287]],"region":{"top_left_x":369,"top_left_y":1248,"width":1443,"height":39},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8a898e8347c048da9e247e263ddd95a5","type":"text","conversion_output":true,"text":"g. Record weight and height at enrollment only. Use weight and height from admission; if none","text_display":"\ng. Record weight and height at enrollment only. Use weight and height from admission; if none","confidence":1,"confidence_rate":1},{"cnt":[[434,1285],[924,1285],[924,1317],[434,1317]],"region":{"top_left_x":433,"top_left_y":1284,"width":491,"height":33},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fb0f5fd98af45039fdb2553d83720b8","type":"text","conversion_output":true,"text":"available measure at enrollment.","text_display":" available measure at enrollment.","confidence":1,"confidence_rate":1},{"cnt":[[370,1319],[1760,1319],[1760,1358],[370,1358]],"region":{"top_left_x":369,"top_left_y":1319,"width":1391,"height":39},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c8e103b73c9746398872393053c5d12e","type":"text","conversion_output":true,"text":"h. Clinical Assessment is done by PI or designated SI and involves clinical judgment based","text_display":"\nh. Clinical Assessment is done by PI or designated SI and involves clinical judgment based","confidence":0.7373046875,"confidence_rate":0.9971558834336636},{"cnt":[[434,1354],[1781,1354],[1781,1394],[434,1394]],"region":{"top_left_x":433,"top_left_y":1353,"width":1349,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"05679bfb4085473da851cf09ccf0a3f5","type":"text","conversion_output":true,"text":"upon all clinical aspects of care (e.g. labs, ECG and/or ECHO if clinically indicated, clinical","text_display":" upon all clinical aspects of care (e.g. labs, ECG and/or ECHO if clinically indicated, clinical","confidence":0.9970734105447718,"confidence_rate":0.99997069162658},{"cnt":[[434,1392],[617,1392],[617,1429],[434,1429]],"region":{"top_left_x":433,"top_left_y":1392,"width":184,"height":37},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"209b9815d17c485aa15dbf69cd7eb919","type":"text","conversion_output":true,"text":"symptoms).","text_display":" symptoms).","confidence":1,"confidence_rate":1},{"cnt":[[370,1427],[1717,1427],[1717,1465],[370,1465]],"region":{"top_left_x":369,"top_left_y":1426,"width":1348,"height":40},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffcacaca06fd458180ebb318275a33e1","type":"text","conversion_output":true,"text":"i. If repeat culture is positive, patient meets criteria for complicated infection and will be","text_display":"\ni. If repeat culture is positive, patient meets criteria for complicated infection and will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1465],[915,1465],[915,1502],[434,1502]],"region":{"top_left_x":433,"top_left_y":1465,"width":483,"height":37},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2006d94de6e3440fbe3281bd7db5367a","type":"text","conversion_output":true,"text":"managed according to table 8.9.","text_display":" managed according to table 8.9.","confidence":1,"confidence_rate":1},{"cnt":[[370,1500],[1695,1500],[1695,1536],[370,1536]],"region":{"top_left_x":369,"top_left_y":1499,"width":1327,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97e6fd48a98c4c32b4e3dd9b7dd5fd9f","type":"text","conversion_output":true,"text":"j. CBC with differential and comprehensive metabolic panel includes the tests listed in","text_display":"\nj. CBC with differential and comprehensive metabolic panel includes the tests listed in","confidence":1,"confidence_rate":1},{"cnt":[[434,1534],[1781,1534],[1781,1573],[434,1573]],"region":{"top_left_x":433,"top_left_y":1533,"width":1349,"height":40},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"957547868ab14817be5edaad18d4dc18","type":"text","conversion_output":true,"text":"Section 8.14.1. If these tests were not run as standard of care prior to randomization, they","text_display":" Section 8.14.1. 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Collect all AEs leading to study drug withdrawal and all SAEs.","text_display":"\nI. Collect all AEs leading to study drug withdrawal and all SAEs.","confidence":1,"confidence_rate":1},{"cnt":[[370,1858],[1676,1858],[1676,1897],[370,1897]],"region":{"top_left_x":369,"top_left_y":1858,"width":1307,"height":40},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a48bc8c7742401eb12bbc6256c4f2af","type":"text","conversion_output":true,"text":"m. Suggest to measure trough vancomycin levels prior to \\(4^{\\text {th }}\\) dose and at steady state.","text_display":"\nm. Suggest to measure trough vancomycin levels prior to \\(4^{\\text {th }}\\) dose and at steady state.","confidence":0.9463655948638916,"confidence_rate":0.9994751252171507},{"cnt":[[370,1895],[1747,1895],[1747,1931],[370,1931]],"region":{"top_left_x":369,"top_left_y":1894,"width":1378,"height":38},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bf5feb52b9614d5aa7129bc23cab9cdb","type":"text","conversion_output":true,"text":"n. For subjects on treatment as outpatients, or continuing treatment after discharge, study","text_display":"\nn. For subjects on treatment as outpatients, or continuing treatment after discharge, study","confidence":1,"confidence_rate":1},{"cnt":[[434,1929],[1807,1929],[1807,1970],[434,1970]],"region":{"top_left_x":433,"top_left_y":1929,"width":1374,"height":42},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffe50bf3d1c942679e6e050f7b7acc5c","type":"text","conversion_output":true,"text":"staff will call patient twice per week and on the scheduled end of treatment day ( \\(\\pm 2\\) days) to","text_display":" staff will call patient twice per week and on the scheduled end of treatment day ( \\(\\pm 2\\) days) to","confidence":0.17387896283488422,"confidence_rate":0.9834771126604087},{"cnt":[[434,1968],[1738,1968],[1738,2004],[434,2004]],"region":{"top_left_x":433,"top_left_y":1967,"width":1306,"height":38},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"792b225595114da798b2a98393afab07","type":"text","conversion_output":true,"text":"confirm drug discontinuation date, concomitant medication usage, and AE information.","text_display":" confirm drug discontinuation date, concomitant medication usage, and AE information.","confidence":1,"confidence_rate":1},{"cnt":[[370,2002],[1807,2002],[1807,2039],[370,2039]],"region":{"top_left_x":369,"top_left_y":2002,"width":1438,"height":37},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7acb530bc8fc467c9b7d6108fdf0891f","type":"text","conversion_output":true,"text":"o. If empiric treatment was started prior to randomization and this treatment is effective for the","text_display":"\no. 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If the patient","confidence":1,"confidence_rate":1},{"cnt":[[434,2144],[1815,2144],[1815,2185],[434,2185]],"region":{"top_left_x":433,"top_left_y":2144,"width":1383,"height":41},"line":55,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11da81fa2b2d4ceab785304b275be185","type":"text","conversion_output":true,"text":"has not received any antibiotic treatment for the index bacteremia prior to randomization, no","text_display":" has not received any antibiotic treatment for the index bacteremia prior to randomization, no","confidence":1,"confidence_rate":1},{"cnt":[[434,2183],[810,2183],[810,2215],[434,2215]],"region":{"top_left_x":433,"top_left_y":2182,"width":377,"height":34},"line":56,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0163acef87084125a88e2aaa116b3521","type":"text","conversion_output":true,"text":"treatment will be started.","text_display":" treatment will be started.","confidence":1,"confidence_rate":1},{"cnt":[[372,2217],[1618,2217],[1618,2258],[372,2258]],"region":{"top_left_x":371,"top_left_y":2217,"width":1247,"height":42},"line":57,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"796a8df1261e46c0815f23985352ce97","type":"text","conversion_output":true,"text":"p. Labs within \\(1 4\\) days of enrollment. Differential required only at Enrollment. For","text_display":"\np. Labs within \\(1 4\\) days of enrollment. Differential required only at Enrollment. 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Baseline bloodstream isolates will","text_display":" their baseline infecting pathogen prior to randomization. Baseline bloodstream isolates will","confidence":1,"confidence_rate":1},{"cnt":[[434,357],[1712,357],[1712,397],[434,397]],"region":{"top_left_x":433,"top_left_y":356,"width":1280,"height":42},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"91e8ee2ccc1d4ada925925a55fe70bfe","type":"text","conversion_output":true,"text":"be collected and stored for shipment until the end of the study, or earlier if requested.","text_display":" be collected and stored for shipment until the end of the study, or earlier if requested.","confidence":1,"confidence_rate":1},{"cnt":[[370,391],[1792,391],[1792,432],[370,432]],"region":{"top_left_x":369,"top_left_y":391,"width":1423,"height":41},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8f80b00c4b3f492b894922dde29be213","type":"text","conversion_output":true,"text":"b. Inpatient End of Treatment (IEOT) or Discharge Visit (DV), whichever occurs first. The IEOT","text_display":"\nb. Inpatient End of Treatment (IEOT) or Discharge Visit (DV), whichever occurs first. The IEOT","confidence":1,"confidence_rate":1},{"cnt":[[434,430],[1807,430],[1807,471],[434,471]],"region":{"top_left_x":433,"top_left_y":429,"width":1374,"height":42},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1e00f1ce23d145c8ad922d7525d29661","type":"text","conversion_output":true,"text":"can be \\(\\pm 2\\) days; the DV can be done up to two calendar days prior to discharge Some CoNS","text_display":" can be \\(\\pm 2\\) days; the DV can be done up to two calendar days prior to discharge Some CoNS","confidence":0.6636193757731235,"confidence_rate":0.9958245931569855},{"cnt":[[434,466],[1772,466],[1772,505],[434,505]],"region":{"top_left_x":433,"top_left_y":466,"width":1340,"height":39},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c67bcc27990c40fe8d885af343c0bd01","type":"text","conversion_output":true,"text":"patients may be treated solely as outpatients. These patients will only have IEOT/DV visit","text_display":" patients may be treated solely as outpatients. These patients will only have IEOT/DV visit","confidence":1,"confidence_rate":1},{"cnt":[[434,503],[1764,503],[1764,541],[434,541]],"region":{"top_left_x":433,"top_left_y":502,"width":1331,"height":40},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"99db824810c04e0594578b57e2aa98b3","type":"text","conversion_output":true,"text":"procedures performed if they have an in-person clinic visit as part of their treatment plan","text_display":" procedures performed if they have an in-person clinic visit as part of their treatment plan","confidence":1,"confidence_rate":1},{"cnt":[[434,537],[1244,537],[1244,574],[434,574]],"region":{"top_left_x":433,"top_left_y":537,"width":811,"height":37},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47742beba179451383cb1051a7eeb733","type":"text","conversion_output":true,"text":"between the enrollment visit and the end of treatment.","text_display":" between the enrollment visit and the end of treatment.","confidence":0.99951171875,"confidence_rate":0.9999917220597181},{"cnt":[[370,574],[1768,574],[1768,612],[370,612]],"region":{"top_left_x":369,"top_left_y":573,"width":1400,"height":40},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f044884eb1df48cf8af9094e8a1e41b2","type":"text","conversion_output":true,"text":"c. Test of Cure (TOC). If patients fail or are determined non-evaluable prior to the scheduled","text_display":"\nc. Test of Cure (TOC). If patients fail or are determined non-evaluable prior to the scheduled","confidence":1,"confidence_rate":1},{"cnt":[[434,610],[1768,610],[1768,649],[434,649]],"region":{"top_left_x":433,"top_left_y":610,"width":1336,"height":39},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1aa52e95ed4b4b268057a6c5ff470a1a","type":"text","conversion_output":true,"text":"TOC visit, all applicable final TOC assessments can be conducted at the time of failure or","text_display":" TOC visit, all applicable final TOC assessments can be conducted at the time of failure or","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[434,645],[1742,645],[1742,685],[434,685]],"region":{"top_left_x":433,"top_left_y":644,"width":1310,"height":42},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"79a6ed18de364b1f980b0cfa0f0837cb","type":"text","conversion_output":true,"text":"non-evaluable determination and the patient can be classified as completing (failure) or","text_display":" non-evaluable determination and the patient can be classified as completing (failure) or","confidence":1,"confidence_rate":1},{"cnt":[[434,683],[1182,683],[1182,724],[434,724]],"region":{"top_left_x":433,"top_left_y":683,"width":749,"height":42},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"715b31092567451fb41559ae15483eb2","type":"text","conversion_output":true,"text":"terminating (non-evaluable) the study at that time.","text_display":" terminating (non-evaluable) the study at that time.","confidence":1,"confidence_rate":1},{"cnt":[[370,718],[1738,718],[1738,758],[370,758]],"region":{"top_left_x":369,"top_left_y":717,"width":1370,"height":42},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e1eced2088c4548b4629f6398872687","type":"text","conversion_output":true,"text":"d. 14-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","text_display":"\nd. 14-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","confidence":0.991706371307373,"confidence_rate":0.9999141458281662},{"cnt":[[434,756],[1783,756],[1783,799],[434,799]],"region":{"top_left_x":433,"top_left_y":756,"width":1351,"height":44},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"43e04a78f895404398062b1d07052c8b","type":"text","conversion_output":true,"text":"(required data obtained from the medical records is acceptable but not preferred). Perform","text_display":" (required data obtained from the medical records is acceptable but not preferred). Perform","confidence":1,"confidence_rate":1},{"cnt":[[434,799],[750,799],[750,840],[434,840]],"region":{"top_left_x":433,"top_left_y":799,"width":317,"height":42},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5621c17e5eb649baa83bc3484d88bafa","type":"text","conversion_output":true,"text":"PE only if clinic visit.","text_display":" PE only if clinic visit.","confidence":0.99560546875,"confidence_rate":0.9998481420286601},{"cnt":[[370,838],[1738,838],[1738,879],[370,879]],"region":{"top_left_x":369,"top_left_y":837,"width":1370,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"094463aa5358481b9e8ce4c5c5c1b89f","type":"text","conversion_output":true,"text":"e. 28-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","text_display":"\ne. 28-4+10 days after last dose of study drug, by clinic visit (preferred) or telephone call","confidence":0.9742902293801308,"confidence_rate":0.9997315201404732},{"cnt":[[434,879],[1785,879],[1785,922],[434,922]],"region":{"top_left_x":433,"top_left_y":878,"width":1353,"height":44},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d8dd4265dd34cb4a270c9b96f71cab8","type":"text","conversion_output":true,"text":"(required data obtained from the medical records is acceptable but not preferred). Perform","text_display":" (required data obtained from the medical records is acceptable but not preferred). Perform","confidence":1,"confidence_rate":1},{"cnt":[[434,920],[752,920],[752,960],[434,960]],"region":{"top_left_x":433,"top_left_y":919,"width":319,"height":42},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c38fab8462b14e11b1f169293d7c48e8","type":"text","conversion_output":true,"text":"PE only if clinic visit.","text_display":" PE only if clinic visit.","confidence":1,"confidence_rate":1},{"cnt":[[370,962],[1699,962],[1699,1003],[370,1003]],"region":{"top_left_x":369,"top_left_y":962,"width":1331,"height":42},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd2b68db4beb4f9b8b7bfa4d41b77f23","type":"text","conversion_output":true,"text":"f. Vital signs are blood pressure, heart rate and temperature; record the most clinically","text_display":"\nf. Vital signs are blood pressure, heart rate and temperature; record the most clinically","confidence":1,"confidence_rate":1},{"cnt":[[434,1001],[1008,1001],[1008,1038],[434,1038]],"region":{"top_left_x":433,"top_left_y":1001,"width":575,"height":37},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ccae182e4df34912888d99a773f5f486","type":"text","conversion_output":true,"text":"significant measurement for that date.","text_display":" significant measurement for that date.","confidence":1,"confidence_rate":1},{"cnt":[[370,1036],[1742,1036],[1742,1076],[370,1076]],"region":{"top_left_x":369,"top_left_y":1035,"width":1374,"height":42},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4e342782858945db90328638d3fcca83","type":"text","conversion_output":true,"text":"g. Record height and weight at enrollment only. Use height and weight from admission; if","text_display":"\ng. Record height and weight at enrollment only. Use height and weight from admission; if","confidence":1,"confidence_rate":1},{"cnt":[[434,1070],[1016,1070],[1016,1109],[434,1109]],"region":{"top_left_x":433,"top_left_y":1069,"width":584,"height":40},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85bad9d65269433e94097a121bee661f","type":"text","conversion_output":true,"text":"none available, measure at enrollment.","text_display":" none available, measure at enrollment.","confidence":1,"confidence_rate":1},{"cnt":[[370,1106],[1760,1106],[1760,1145],[370,1145]],"region":{"top_left_x":369,"top_left_y":1106,"width":1391,"height":40},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c76501cc5ddd446eaf33e0a981a7ab0b","type":"text","conversion_output":true,"text":"h. Clinical Assessment is done by PI or designated SI and involves clinical judgment based","text_display":"\nh. Clinical Assessment is done by PI or designated SI and involves clinical judgment based","confidence":0.5427088711876422,"confidence_rate":0.9935871532494831},{"cnt":[[434,1143],[1783,1143],[1783,1182],[434,1182]],"region":{"top_left_x":433,"top_left_y":1142,"width":1351,"height":40},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f1f46f7887de421394fce7d393b7e618","type":"text","conversion_output":true,"text":"upon all clinical aspects of care (e.g. labs, ECG and/or ECHO if clinically indicated, clinical","text_display":" upon all clinical aspects of care (e.g. labs, ECG and/or ECHO if clinically indicated, clinical","confidence":0.9980480668600649,"confidence_rate":0.999980461784433},{"cnt":[[434,1179],[617,1179],[617,1218],[434,1218]],"region":{"top_left_x":433,"top_left_y":1179,"width":184,"height":40},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b510b226a3074f669689f02be1552e7e","type":"text","conversion_output":true,"text":"symptoms).","text_display":" symptoms).","confidence":1,"confidence_rate":1},{"cnt":[[370,1216],[1704,1216],[1704,1253],[370,1253]],"region":{"top_left_x":369,"top_left_y":1216,"width":1335,"height":37},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c90ed9e740bc4bada9b8e1c7a2759c01","type":"text","conversion_output":true,"text":"i. If repeat cultures positive, patient meets criteria for complicated infection and will be","text_display":"\ni. If repeat cultures positive, patient meets criteria for complicated infection and will be","confidence":1,"confidence_rate":1},{"cnt":[[434,1250],[1729,1250],[1729,1291],[434,1291]],"region":{"top_left_x":433,"top_left_y":1250,"width":1297,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"67a803e409314ad7bfe423e04550dbce","type":"text","conversion_output":true,"text":"managed according to table \\(8 . 9\\). Blood cultures will be repeated every \\(1 - 2\\) days until all","text_display":" managed according to table \\(8 . 9\\). Blood cultures will be repeated every \\(1 - 2\\) days until all","confidence":0.31066401056060267,"confidence_rate":0.9893321416309099},{"cnt":[[434,1289],[1437,1289],[1437,1326],[434,1326]],"region":{"top_left_x":433,"top_left_y":1289,"width":1005,"height":37},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9c1555e9028f409197f81e8c5e479549","type":"text","conversion_output":true,"text":"cultures obtained within the past 48 hours have remained negative.","text_display":" cultures obtained within the past 48 hours have remained negative.","confidence":0.83984375,"confidence_rate":0.9976441386459713},{"cnt":[[370,1323],[1695,1323],[1695,1364],[370,1364]],"region":{"top_left_x":369,"top_left_y":1323,"width":1327,"height":42},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a5ec70626a3e4c4bb708394747bc1f3a","type":"text","conversion_output":true,"text":"j. CBC with differential and comprehensive metabolic panel includes the tests listed in","text_display":"\nj. CBC with differential and comprehensive metabolic panel includes the tests listed in","confidence":1,"confidence_rate":1},{"cnt":[[434,1358],[1781,1358],[1781,1399],[434,1399]],"region":{"top_left_x":433,"top_left_y":1357,"width":1349,"height":42},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf473e3fdcad4de3a5595e9032722302","type":"text","conversion_output":true,"text":"Section 8.14.1. If these tests were not run as standard of care prior to randomization, they","text_display":" Section 8.14.1. If these tests were not run as standard of care prior to randomization, they","confidence":1,"confidence_rate":1},{"cnt":[[434,1396],[1171,1396],[1171,1433],[434,1433]],"region":{"top_left_x":433,"top_left_y":1396,"width":738,"height":38},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"521322dccac14e9f8d12cc589fe9fc04","type":"text","conversion_output":true,"text":"should be requested at the time of randomization","text_display":" should be requested at the time of randomization","confidence":1,"confidence_rate":1},{"cnt":[[370,1431],[1708,1431],[1708,1472],[370,1472]],"region":{"top_left_x":369,"top_left_y":1430,"width":1340,"height":42},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d9ecdd149e2546d89fece28c5b0d90d2","type":"text","conversion_output":true,"text":"k. Empiric treatment for Gram-negative pathogens is allowable; these agents will not be","text_display":"\nk. Empiric treatment for Gram-negative pathogens is allowable; these agents will not be","confidence":1,"confidence_rate":1},{"cnt":[[434,1470],[1768,1470],[1768,1506],[434,1506]],"region":{"top_left_x":433,"top_left_y":1469,"width":1336,"height":38},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4f65ddcb13d041fa9ab84e2f3eb372fb","type":"text","conversion_output":true,"text":"counted when calculating antibiotic days unless susceptibility testing of the bloodstream","text_display":" counted when calculating antibiotic days unless susceptibility testing of the bloodstream","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[434,1504],[1781,1504],[1781,1540],[434,1540]],"region":{"top_left_x":433,"top_left_y":1503,"width":1349,"height":38},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3494be925e3d4cfca776cdd2c67d1248","type":"text","conversion_output":true,"text":"staphylococcal isolate reveals that the staphylococcus is susceptible to the antibiotic and","text_display":" staphylococcal isolate reveals that the staphylococcus is susceptible to the antibiotic and","confidence":1,"confidence_rate":1},{"cnt":[[434,1538],[1794,1538],[1794,1579],[434,1579]],"region":{"top_left_x":433,"top_left_y":1538,"width":1361,"height":42},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bdb94f320124b9c8ce6f8a99b87871a","type":"text","conversion_output":true,"text":"the patient is not receiving other antistaphylococcal treatment (e.g., methicillin-susceptible","text_display":" the patient is not receiving other antistaphylococcal treatment (e.g., methicillin-susceptible","confidence":1,"confidence_rate":1},{"cnt":[[434,1575],[1790,1575],[1790,1613],[434,1613]],"region":{"top_left_x":433,"top_left_y":1574,"width":1357,"height":40},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26fcbf1295e845e480048215d475fbab","type":"text","conversion_output":true,"text":"staphylococcal bloodstream isolate from a patient receiving empiric beta-lactam treatment","text_display":" staphylococcal bloodstream isolate from a patient receiving empiric beta-lactam treatment","confidence":1,"confidence_rate":1},{"cnt":[[434,1611],[874,1611],[874,1648],[434,1648]],"region":{"top_left_x":433,"top_left_y":1611,"width":442,"height":37},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"eca9b7c8f2a84ce18a6da9191ee79ecd","type":"text","conversion_output":true,"text":"for gram-negative treatment).","text_display":" for gram-negative treatment).","confidence":1,"confidence_rate":1},{"cnt":[[370,1646],[1317,1646],[1317,1687],[370,1687]],"region":{"top_left_x":369,"top_left_y":1645,"width":948,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22ffb37ec5de4c42925b7e972cf06fa7","type":"text","conversion_output":true,"text":"I. Collect AEs leading to study drug withdrawal and all SAEs.","text_display":"\nI. Collect AEs leading to study drug withdrawal and all SAEs.","confidence":1,"confidence_rate":1},{"cnt":[[370,1680],[1678,1680],[1678,1721],[370,1721]],"region":{"top_left_x":369,"top_left_y":1680,"width":1309,"height":41},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47054e5f973a484eacb1f1b514b6a8cb","type":"text","conversion_output":true,"text":"m. Suggest to measure trough vancomycin levels prior to \\(4^{\\text {th }}\\) dose and at steady state.","text_display":"\nm. Suggest to measure trough vancomycin levels prior to \\(4^{\\text {th }}\\) dose and at steady state.","confidence":0.9912109375,"confidence_rate":0.9999159281616297},{"cnt":[[370,1719],[1749,1719],[1749,1757],[370,1757]],"region":{"top_left_x":369,"top_left_y":1718,"width":1380,"height":40},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d1bcee941bf49c8aafc6602728522d8","type":"text","conversion_output":true,"text":"n. For subjects on treatment as outpatients, or continuing treatment after discharge, study","text_display":"\nn. For subjects on treatment as outpatients, or continuing treatment after discharge, study","confidence":1,"confidence_rate":1},{"cnt":[[434,1753],[1807,1753],[1807,1794],[434,1794]],"region":{"top_left_x":433,"top_left_y":1753,"width":1374,"height":41},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1d12aa838529422980e92151f214dfc1","type":"text","conversion_output":true,"text":"staff will call patient twice per week and on the scheduled end of treatment day ( \\(\\pm 2\\) days) to","text_display":" staff will call patient twice per week and on the scheduled end of treatment day ( \\(\\pm 2\\) days) to","confidence":0.17655731509040268,"confidence_rate":0.983620299683304},{"cnt":[[434,1792],[1738,1792],[1738,1828],[434,1828]],"region":{"top_left_x":433,"top_left_y":1791,"width":1306,"height":38},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c71fb9a3db843d4b66409a2eb82a0e7","type":"text","conversion_output":true,"text":"confirm drug discontinuation date, concomitant medication usage, and AE information.","text_display":" confirm drug discontinuation date, concomitant medication usage, and AE information.","confidence":1,"confidence_rate":1},{"cnt":[[370,1826],[1809,1826],[1809,1865],[370,1865]],"region":{"top_left_x":369,"top_left_y":1826,"width":1440,"height":39},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"069231ec282744a0b3223c46ed7615a5","type":"text","conversion_output":true,"text":"o. If empiric treatment was started prior to randomization and this treatment is effective for the","text_display":"\no. 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Labs within \\(1 4\\) days of enrollment. Differential required only at Enrollment. For","text_display":"\nm. Labs within \\(1 4\\) days of enrollment. Differential required only at Enrollment. 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The echocardiogram","text_display":" and data collected with the exception of the echocardiography. The echocardiogram","confidence":1,"confidence_rate":1},{"cnt":[[309,455],[1648,455],[1648,505],[309,505]],"region":{"top_left_x":309,"top_left_y":455,"width":1339,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f71c0ce5fc704a239d7d06ffb3988450","type":"text","conversion_output":true,"text":"(TEE preferred) is not obligatory in the Standard of Care treatment group but is","text_display":" (TEE preferred) is not obligatory in the Standard of Care treatment group but is","confidence":0.9970703125,"confidence_rate":0.9999654830964892},{"cnt":[[309,507],[1790,507],[1790,554],[309,554]],"region":{"top_left_x":309,"top_left_y":507,"width":1481,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e11849b0d9ea4846b28d72de28dd748b","type":"text","conversion_output":true,"text":"mandatory in the Algorithm group for patients with cultures positive for S. aureus. Refer","text_display":" mandatory in the Algorithm group for patients with cultures positive for S. aureus. 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The committee chair will be responsible for ensuring accuracy and","text_display":" in the charter. The committee chair will be responsible for ensuring accuracy and","confidence":1,"confidence_rate":1},{"cnt":[[305,352],[1766,352],[1766,397],[305,397]],"region":{"top_left_x":305,"top_left_y":352,"width":1462,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcf7854e8887473ebae2696997279d2f","type":"text","conversion_output":true,"text":"compliance with the charter. Five percent of all the cases reviewed in the first session","text_display":" compliance with the charter. 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In addition, the de-identified","confidence":1,"confidence_rate":1},{"cnt":[[305,797],[1807,797],[1807,844],[305,844]],"region":{"top_left_x":305,"top_left_y":797,"width":1502,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1c50a0f717c41598594d7e5066a1bb1","type":"text","conversion_output":true,"text":"echo study recorded on CD will be sent to DCRI and be reinterpreted by an experienced","text_display":" echo study recorded on CD will be sent to DCRI and be reinterpreted by an experienced","confidence":1,"confidence_rate":1},{"cnt":[[305,846],[1549,846],[1549,896],[305,896]],"region":{"top_left_x":305,"top_left_y":846,"width":1245,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c754e848eb64edd99227b519cd9300a","type":"text","conversion_output":true,"text":"echocardiographer at the DCRI Echocardiography Core Laboratory. The","text_display":" echocardiographer at the DCRI Echocardiography Core Laboratory. The","confidence":1,"confidence_rate":1},{"cnt":[[305,898],[1480,898],[1480,943],[305,943]],"region":{"top_left_x":305,"top_left_y":898,"width":1176,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37332c657f304ed2841aeca703e8a0d0","type":"text","conversion_output":true,"text":"echocardiographer will be blinded to the clinical details of the patient.","text_display":" echocardiographer will be blinded to the clinical details of the patient.","confidence":1,"confidence_rate":1},{"cnt":[[305,993],[1747,993],[1747,1038],[305,1038]],"region":{"top_left_x":305,"top_left_y":992,"width":1442,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dce0b7f5aba34bc39549c7ab78c6cd78","type":"text","conversion_output":true,"text":"The following selection criteria will be used to determine which study is reinterpreted:","text_display":"\n\nThe following selection criteria will be used to determine which study is reinterpreted:","confidence":1,"confidence_rate":1},{"cnt":[[382,1042],[1745,1042],[1745,1089],[382,1089]],"region":{"top_left_x":382,"top_left_y":1041,"width":1363,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"107c4c9ef2d54f73be25f2a213ddd485","type":"text","conversion_output":true,"text":"a. If a single protocol required echocardiogram is performed, it will be sent for","text_display":"\na. If a single protocol required echocardiogram is performed, it will be sent for","confidence":1,"confidence_rate":1},{"cnt":[[468,1091],[746,1091],[746,1141],[468,1141]],"region":{"top_left_x":468,"top_left_y":1091,"width":278,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce6cb41d8f8f4afdb84c399b2c948c9e","type":"text","conversion_output":true,"text":"reinterpretation.","text_display":" reinterpretation.","confidence":1,"confidence_rate":1},{"cnt":[[382,1143],[1721,1143],[1721,1188],[382,1188]],"region":{"top_left_x":382,"top_left_y":1142,"width":1339,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb5747d43e8f42bbbce73be52dedc37a","type":"text","conversion_output":true,"text":"b. If multiple echocardiograms are performed then the study that is the most","text_display":"\nb. If multiple echocardiograms are performed then the study that is the most","confidence":1,"confidence_rate":1},{"cnt":[[468,1190],[1454,1190],[1454,1240],[468,1240]],"region":{"top_left_x":468,"top_left_y":1190,"width":987,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ba7e31de8524c58a6040ff1024e5ce4","type":"text","conversion_output":true,"text":"diagnostic for endocarditis will be sent for reinterpretation.","text_display":" diagnostic for endocarditis will be sent for reinterpretation.","confidence":1,"confidence_rate":1},{"cnt":[[382,1242],[1775,1242],[1775,1291],[382,1291]],"region":{"top_left_x":382,"top_left_y":1241,"width":1393,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ad5de359e63499493e7fabe8b5110c1","type":"text","conversion_output":true,"text":"c. If multiple echocardiograms are performed, but none are diagnostic, then the","text_display":"\nc. If multiple echocardiograms are performed, but none are diagnostic, then the","confidence":1,"confidence_rate":1},{"cnt":[[468,1293],[1807,1293],[1807,1343],[468,1343]],"region":{"top_left_x":468,"top_left_y":1293,"width":1339,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d78f861f0dff4f8cbc5c09a3132b9cf3","type":"text","conversion_output":true,"text":"first study following the initial diagnosis of \\(S\\). aureus bacteremia will be sent for","text_display":" first study following the initial diagnosis of \\(S\\). aureus bacteremia will be sent for","confidence":0.9507308006286621,"confidence_rate":0.9994568752198868},{"cnt":[[468,1343],[1768,1343],[1768,1390],[468,1390]],"region":{"top_left_x":468,"top_left_y":1342,"width":1301,"height":49},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c28b2d7e5314a9eb920f3ef4cfe58ed","type":"text","conversion_output":true,"text":"reinterpretation. If both a TTE and TEE have been performed, and none are","text_display":" reinterpretation. If both a TTE and TEE have been performed, and none are","confidence":1,"confidence_rate":1},{"cnt":[[468,1392],[1811,1392],[1811,1442],[468,1442]],"region":{"top_left_x":468,"top_left_y":1392,"width":1344,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"000dba00e9b34e9a9f52ac301e6bf04e","type":"text","conversion_output":true,"text":"diagnostic, then the first TEE following initial diagnosis of \\(S\\). aureus bacteremia","text_display":" diagnostic, then the first TEE following initial diagnosis of \\(S\\). aureus bacteremia","confidence":0.9863345623016357,"confidence_rate":0.9998488062742874},{"cnt":[[468,1444],[999,1444],[999,1489],[468,1489]],"region":{"top_left_x":468,"top_left_y":1443,"width":532,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f70ba53cb214706958dc6f3813e4d82","type":"text","conversion_output":true,"text":"will be sent for reinterpretation.","text_display":" will be sent for reinterpretation.","confidence":1,"confidence_rate":1},{"cnt":[[316,1543],[1800,1543],[1800,1592],[316,1592]],"region":{"top_left_x":315,"top_left_y":1542,"width":1486,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5c28d718e8b429a89898dcaa2cbcbec","type":"text","conversion_output":true,"text":"A comparison between the site and central echocardiogram readings will be performed.","text_display":"\n\nA comparison between the site and central echocardiogram readings will be performed.","confidence":0.9990234375,"confidence_rate":0.9999890220866866},{"cnt":[[309,1594],[1785,1594],[1785,1641],[309,1641]],"region":{"top_left_x":309,"top_left_y":1594,"width":1477,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45f2be1203b849948948f0989a680771","type":"text","conversion_output":true,"text":"If there are discrepancies, then only the site interpretation will be reported on the eCRF","text_display":" If there are discrepancies, then only the site interpretation will be reported on the eCRF","confidence":0.998046875,"confidence_rate":0.9999794208976915},{"cnt":[[309,1644],[1798,1644],[1798,1691],[309,1691]],"region":{"top_left_x":309,"top_left_y":1643,"width":1490,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97a84b9bce044584886d8fa0bbaf171a","type":"text","conversion_output":true,"text":"and used for clinical decision-making at the study site. Patient outcome at final TOC for","text_display":" and used for clinical decision-making at the study site. Patient outcome at final TOC for","confidence":1,"confidence_rate":1},{"cnt":[[307,1693],[1815,1693],[1815,1742],[307,1742]],"region":{"top_left_x":307,"top_left_y":1692,"width":1509,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75beeae82b3943889121962b01038d0f","type":"text","conversion_output":true,"text":"those patients randomly selected for CEC adjudication of outcome, will also be assessed","text_display":" those patients randomly selected for CEC adjudication of outcome, will also be assessed","confidence":1,"confidence_rate":1},{"cnt":[[305,1745],[1794,1745],[1794,1792],[305,1792]],"region":{"top_left_x":305,"top_left_y":1744,"width":1489,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e29eda0d710142c095849ca95830c0d7","type":"text","conversion_output":true,"text":"by the CEC using the interpretation of the Echocardiography Core Laboratory to ensure","text_display":" by the CEC using the interpretation of the Echocardiography Core Laboratory to ensure","confidence":1,"confidence_rate":1},{"cnt":[[305,1792],[1609,1792],[1609,1841],[305,1841]],"region":{"top_left_x":305,"top_left_y":1791,"width":1305,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2134c992fdf94621ae5b23d0889990be","type":"text","conversion_output":true,"text":"that no bias is introduced by the fact that the onsite clinicians interpreting the","text_display":" that no bias is introduced by the fact that the onsite clinicians interpreting the","confidence":1,"confidence_rate":1},{"cnt":[[305,1843],[1639,1843],[1639,1893],[305,1893]],"region":{"top_left_x":305,"top_left_y":1843,"width":1335,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c705008a76e404ea78e02069273f830","type":"text","conversion_output":true,"text":"echocardiogram know the clinical condition of the patient. See Section 8.13.1.","text_display":" echocardiogram know the clinical condition of the patient. See Section 8.13.1.","confidence":1,"confidence_rate":1},{"cnt":[[309,1936],[1721,1936],[1721,1983],[309,1983]],"region":{"top_left_x":309,"top_left_y":1935,"width":1412,"height":49},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4467635a6a1e4f3f87a35c833a911ac4","type":"text","conversion_output":true,"text":"Echocardiography may also be performed for clinical assessments and read by site","text_display":"\n\nEchocardiography may also be performed for clinical assessments and read by site","confidence":0.9912109375,"confidence_rate":0.9998961475798176},{"cnt":[[309,1985],[1755,1985],[1755,2035],[309,2035]],"region":{"top_left_x":309,"top_left_y":1985,"width":1447,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b72aa7f0a0904f08a46cd6e361d11b17","type":"text","conversion_output":true,"text":"echocardiographer per standard clinical practice, but a CD recording should not be","text_display":" echocardiographer per standard clinical practice, but a CD recording should not be","confidence":1,"confidence_rate":1},{"cnt":[[309,2037],[1506,2037],[1506,2084],[309,2084]],"region":{"top_left_x":309,"top_left_y":2036,"width":1198,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e35620d14724c698acb061606a48b24","type":"text","conversion_output":true,"text":"submitted as it will not be reinterpreted by the central Core Laboratory.","text_display":" submitted as it will not be reinterpreted by the central Core 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was randomized; other TEE/TTE abnormalities will be","confidence":1,"confidence_rate":1},{"cnt":[[309,748],[1042,748],[1042,793],[309,793]],"region":{"top_left_x":309,"top_left_y":747,"width":733,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"616c4c459a314d68aa4a103bcb009d4e","type":"text","conversion_output":true,"text":"managed according to routine clinical care.","text_display":" managed according to routine clinical 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The initial report must be as complete as possible,","confidence":1,"confidence_rate":1},{"cnt":[[309,1334],[1794,1334],[1794,1377],[309,1377]],"region":{"top_left_x":309,"top_left_y":1334,"width":1485,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db7923d0037c41ba95b0ee41441c8305","type":"text","conversion_output":true,"text":"including details of the SAE, and provide an investigator assessment of severity and the","text_display":" including details of the SAE, and provide an investigator assessment of severity and the","confidence":1,"confidence_rate":1},{"cnt":[[309,1384],[1760,1384],[1760,1429],[309,1429]],"region":{"top_left_x":309,"top_left_y":1383,"width":1451,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d3e703ea5494c00972be22b1d186dd5","type":"text","conversion_output":true,"text":"causal relationship between the event and the investigational product. Information not","text_display":" causal relationship between the event and the investigational product. Information not","confidence":1,"confidence_rate":1},{"cnt":[[309,1435],[1772,1435],[1772,1480],[309,1480]],"region":{"top_left_x":309,"top_left_y":1435,"width":1464,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e83c08efea04423f956edbe73eeabccd","type":"text","conversion_output":true,"text":"available at the time of the initial reporting must be documented on SAE eCRF page in","text_display":" available at the time of the initial reporting must be documented on SAE eCRF page in","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[309,1482],[1240,1482],[1240,1528],[309,1528]],"region":{"top_left_x":309,"top_left_y":1482,"width":931,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be4c8b986db843a59d85ba5700e31a17","type":"text","conversion_output":true,"text":"Inform within 24 hours of knowledge of the information.","text_display":" Inform within 24 hours of knowledge of the information.","confidence":1,"confidence_rate":1},{"cnt":[[309,1577],[1790,1577],[1790,1620],[309,1620]],"region":{"top_left_x":309,"top_left_y":1576,"width":1481,"height":44},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1877c07def94fe3b9a978173416d9d3","type":"text","conversion_output":true,"text":"DCRI Safety Surveillance, the DMID Medical Monitor and the DMID Pharmacovigilance","text_display":"\n\nDCRI Safety Surveillance, the DMID Medical Monitor and the DMID Pharmacovigilance","confidence":1,"confidence_rate":1},{"cnt":[[309,1626],[1796,1626],[1796,1669],[309,1669]],"region":{"top_left_x":309,"top_left_y":1626,"width":1488,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0b27a89947429a8e3cfb9e83fde29a","type":"text","conversion_output":true,"text":"designee will receive a real-time automated SAE email notification when data is entered","text_display":" designee will receive a real-time automated SAE email notification when data is entered","confidence":1,"confidence_rate":1},{"cnt":[[309,1676],[1766,1676],[1766,1721],[309,1721]],"region":{"top_left_x":309,"top_left_y":1675,"width":1458,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd9617b8b6e2443d8e661498f9586667","type":"text","conversion_output":true,"text":"or changed on the SAE eCRF in InForm. DCRI Safety Surveillance will be responsible","text_display":" or changed on the SAE eCRF in InForm. DCRI Safety Surveillance will be responsible","confidence":1,"confidence_rate":1},{"cnt":[[309,1727],[1811,1727],[1811,1768],[309,1768]],"region":{"top_left_x":309,"top_left_y":1727,"width":1503,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"751154f9c2384e869ce07d1d240e7801","type":"text","conversion_output":true,"text":"for reviewing SAE eCRF data, querying sites within InForm for additional or missing SAE","text_display":" for reviewing SAE eCRF data, querying sites within InForm for additional or missing SAE","confidence":1,"confidence_rate":1},{"cnt":[[309,1779],[1760,1779],[1760,1820],[309,1820]],"region":{"top_left_x":309,"top_left_y":1778,"width":1451,"height":42},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93325745042d4c6bb987d43495f17e19","type":"text","conversion_output":true,"text":"data, and generating SAE reports. SAEs confirmed to meet protocol specific reporting","text_display":" data, and generating SAE reports. SAEs confirmed to meet protocol specific reporting","confidence":1,"confidence_rate":1},{"cnt":[[309,1826],[1781,1826],[1781,1871],[309,1871]],"region":{"top_left_x":309,"top_left_y":1826,"width":1473,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20bfd83662ff457fa4d2b17aa133808d","type":"text","conversion_output":true,"text":"criteria will be forwarded to DMID Pharmacovigilance within 1 business days of receipt.","text_display":" criteria will be forwarded to DMID Pharmacovigilance within 1 business days of receipt.","confidence":1,"confidence_rate":1},{"cnt":[[309,1878],[1790,1878],[1790,1921],[309,1921]],"region":{"top_left_x":309,"top_left_y":1877,"width":1481,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb40d65ac44b4e929bd502fed73d87d2","type":"text","conversion_output":true,"text":"DMID Pharmacovigilance will process all SAE reports and forward to the DMID Medical","text_display":" DMID Pharmacovigilance will process all SAE reports and forward to the DMID Medical","confidence":1,"confidence_rate":1},{"cnt":[[309,1927],[1710,1927],[1710,1970],[309,1970]],"region":{"top_left_x":309,"top_left_y":1927,"width":1402,"height":44},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b8518aeffcd4d828a708cee40f64a6a","type":"text","conversion_output":true,"text":"Monitor. DMID Pharmacovigilance will forward any additional SAE queries to DCRI","text_display":" Monitor. DMID Pharmacovigilance will forward any additional SAE queries to DCRI","confidence":1,"confidence_rate":1},{"cnt":[[309,1977],[1381,1977],[1381,2022],[309,2022]],"region":{"top_left_x":309,"top_left_y":1976,"width":1073,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87911a7d18c9441695e779d8e73b2b6c","type":"text","conversion_output":true,"text":"Safety Surveillance to be entered into InForm clinical database.","text_display":" Safety Surveillance to be entered into InForm clinical database.","confidence":1,"confidence_rate":1},{"cnt":[[309,2069],[1639,2069],[1639,2116],[309,2116]],"region":{"top_left_x":309,"top_left_y":2068,"width":1331,"height":49},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f3e2bac328b47ef9b01bb66dccfa2b4","type":"text","conversion_output":true,"text":"Questions about SAE reporting can be referred to DCRI Safety Surveillance at","text_display":"\n\nQuestions about SAE reporting can be referred to DCRI Safety Surveillance at","confidence":1,"confidence_rate":1},{"cnt":[[309,2118],[1304,2118],[1304,2163],[309,2163]],"region":{"top_left_x":309,"top_left_y":2118,"width":996,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2aee894da78467883c77fb98072d72b","type":"text","conversion_output":true,"text":"919-668-8624, or at 866-668-7799 (North America only).","text_display":" 919-668-8624, or at 866-668-7799 (North America only).","confidence":1,"confidence_rate":1},{"cnt":[[309,2211],[1661,2211],[1661,2254],[309,2254]],"region":{"top_left_x":309,"top_left_y":2210,"width":1352,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ade89dfb4dc4e158fae4fbc5cc883b6","type":"text","conversion_output":true,"text":"Other supporting documentation of the event may be requested by DCRI Safety","text_display":"\n\nOther supporting documentation of the event may be requested by DCRI Safety","confidence":1,"confidence_rate":1},{"cnt":[[309,2260],[1287,2260],[1287,2305],[309,2305]],"region":{"top_left_x":309,"top_left_y":2260,"width":978,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5802663d0414f2aa44e4d0e2cb5e753","type":"text","conversion_output":true,"text":"Surveillance and should be provided as soon as possible.","text_display":" Surveillance and should be provided as soon as possible.","confidence":1,"confidence_rate":1},{"cnt":[[309,2353],[1755,2353],[1755,2396],[309,2396]],"region":{"top_left_x":309,"top_left_y":2352,"width":1447,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2bb14af01d4a47448594abca0a6bdefc","type":"text","conversion_output":true,"text":"All SAEs and all AEs leading to study drug withdrawal will be followed by the site until","text_display":"\n\nAll SAEs and all AEs leading to study drug withdrawal will be followed by the site until","confidence":1,"confidence_rate":1},{"cnt":[[309,2402],[1783,2402],[1783,2447],[309,2447]],"region":{"top_left_x":309,"top_left_y":2401,"width":1475,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76b476850fb14d509487adfe3d7080a7","type":"text","conversion_output":true,"text":"satisfactory resolution or until the investigator deems the event to be chronic and/or the","text_display":" satisfactory resolution or until the investigator deems the event to be chronic and/or the","confidence":0.9990234375,"confidence_rate":0.9999897154250147},{"cnt":[[309,2454],[1794,2454],[1794,2499],[309,2499]],"region":{"top_left_x":309,"top_left_y":2453,"width":1485,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19537cc75f1448edbe50d9c0273a99f5","type":"text","conversion_output":true,"text":"patient to be stable. DCRI Safety Surveillance will followall reported SAEs until resolved","text_display":" patient to be stable. DCRI Safety Surveillance will followall reported SAEs until resolved","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1089,2582],[1089,2625],[1038,2625]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":44},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3d24dc82b4164888bc69a34cc83785e0","type":"page_info","conversion_output":false,"text":"60","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-075","page":75,"lines":[{"cnt":[[309,125],[1119,125],[1119,163],[309,163]],"region":{"top_left_x":309,"top_left_y":124,"width":811,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3574e226024f467286d1dde2b970ddc4","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus Septicemia","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1650,127],[1815,127],[1815,157],[1650,157]],"region":{"top_left_x":1650,"top_left_y":126,"width":166,"height":31},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0651cba9cfbb481ab05ae5fa8ba52d3e","type":"page_info","conversion_output":false,"text":"Version 5.0","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[1547,163],[1815,163],[1815,196],[1547,196]],"region":{"top_left_x":1546,"top_left_y":163,"width":270,"height":33},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e37b3a5174f345289fe914f294996df7","type":"page_info","conversion_output":false,"text":"05 November 2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[309,254],[1755,254],[1755,299],[309,299]],"region":{"top_left_x":309,"top_left_y":253,"width":1447,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec9b8148e011405c89ef21f167944b7b","type":"text","conversion_output":true,"text":"or stabilized or until the trial database lock. For any ongoing SAE after database lock,","text_display":"\nor stabilized or until the trial database lock. For any ongoing SAE after database lock,","confidence":1,"confidence_rate":1},{"cnt":[[309,301],[1575,301],[1575,346],[309,346]],"region":{"top_left_x":309,"top_left_y":300,"width":1266,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"773fb238b85a4c32bfe1126f00e089d3","type":"text","conversion_output":true,"text":"the sites will be instructed to forward follow-up information directly to DMID","text_display":" the sites will be instructed to forward follow-up information directly to DMID","confidence":1,"confidence_rate":1},{"cnt":[[309,352],[1652,352],[1652,397],[309,397]],"region":{"top_left_x":309,"top_left_y":352,"width":1344,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98930fbe377c46eb9e57b944cd56cad8","type":"text","conversion_output":true,"text":"Pharmacovigilance. If the event resolves during the study or follow-up period, a","text_display":" Pharmacovigilance. If the event resolves during the study or follow-up period, a","confidence":1,"confidence_rate":1},{"cnt":[[309,404],[1259,404],[1259,440],[309,440]],"region":{"top_left_x":309,"top_left_y":403,"width":950,"height":38},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62f85f346c7844fabf7a8f65f17a36c9","type":"text","conversion_output":true,"text":"resolution date should be documented on the AE eCRF.","text_display":" resolution date should be documented on the AE eCRF.","confidence":1,"confidence_rate":1},{"cnt":[[305,584],[965,584],[965,638],[305,638]],"region":{"top_left_x":305,"top_left_y":584,"width":660,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7edcd5e9569a4a79802f7c4c66acb968","type":"section_header","conversion_output":false,"children_ids":["57470324eda041098a23537ef313daca"],"text":"","text_display":""},{"cnt":[[309,589],[965,589],[965,638],[309,638]],"region":{"top_left_x":309,"top_left_y":588,"width":656,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57470324eda041098a23537ef313daca","type":"text","conversion_output":true,"parent_id":"7edcd5e9569a4a79802f7c4c66acb968","text":"9.3.2 Reporting of Pregnancy","text_display":"\n\n\\subsection*{9.3.2 Reporting of Pregnancy}","confidence":1,"confidence_rate":1},{"cnt":[[309,677],[1760,677],[1760,720],[309,720]],"region":{"top_left_x":309,"top_left_y":676,"width":1451,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e09a04a89bb434386b85d15015ca21d","type":"text","conversion_output":true,"text":"Pregnant patients are excluded from enrolling in this trial and participants are strongly","text_display":"\n\nPregnant patients are excluded from enrolling in this trial and participants are strongly","confidence":1,"confidence_rate":1},{"cnt":[[309,726],[1732,726],[1732,771],[309,771]],"region":{"top_left_x":309,"top_left_y":726,"width":1423,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a22c789bf0ab4f88821b19e26d13c1e4","type":"text","conversion_output":true,"text":"discouraged from becoming pregnant while enrolled in the trial. If a study participant","text_display":" discouraged from becoming pregnant while enrolled in the trial. If a study participant","confidence":1,"confidence_rate":1},{"cnt":[[309,778],[1790,778],[1790,821],[309,821]],"region":{"top_left_x":309,"top_left_y":777,"width":1481,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da7f22b3000740c9baf577c676ec3b59","type":"text","conversion_output":true,"text":"does become pregnant during the course of the study, the site will follow the pregnancy","text_display":" does become pregnant during the course of the study, the site will follow the pregnancy","confidence":1,"confidence_rate":1},{"cnt":[[309,825],[1751,825],[1751,870],[309,870]],"region":{"top_left_x":309,"top_left_y":825,"width":1442,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"839970883da34b13b1667ad89f0ff3dc","type":"text","conversion_output":true,"text":"through 8 weeks post-live delivery or elective or natural termination of the pregnancy,","text_display":" through 8 weeks post-live delivery or elective or natural termination of the pregnancy,","confidence":0.9931640625,"confidence_rate":0.9999277982956065},{"cnt":[[309,877],[1725,877],[1725,922],[309,922]],"region":{"top_left_x":309,"top_left_y":876,"width":1417,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b80c437e4f349248f5aa1fd4a187069","type":"text","conversion_output":true,"text":"whichever occurs first. If an SAE occurs in conjunction with the pregnancy the SAE","text_display":" whichever occurs first. 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The form should be completed with as much information as is","text_display":" (North America only). 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See Section 9.3.1 for detailed","confidence":1,"confidence_rate":1},{"cnt":[[309,1276],[1293,1276],[1293,1326],[309,1326]],"region":{"top_left_x":309,"top_left_y":1276,"width":985,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba83f96a56ab4177bc7b120c65ffe1b3","type":"text","conversion_output":true,"text":"information regarding follow-up timelines of SAE and AEs.","text_display":" information regarding follow-up timelines of SAE and AEs.","confidence":1,"confidence_rate":1},{"cnt":[[305,1388],[831,1388],[831,1450],[305,1450]],"region":{"top_left_x":305,"top_left_y":1387,"width":527,"height":64},"line":23,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"3148ee488a1641d6bebd18502efc101a","type":"section_header","conversion_output":false,"children_ids":["097e87f4d19547c2b647030c7055becb"],"text":"","text_display":""},{"cnt":[[309,1392],[827,1392],[827,1446],[309,1446]],"region":{"top_left_x":309,"top_left_y":1392,"width":519,"height":54},"line":24,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"097e87f4d19547c2b647030c7055becb","type":"text","conversion_output":true,"parent_id":"3148ee488a1641d6bebd18502efc101a","text":"9.5 Safety Oversight","text_display":"\n\n\\subsection*{9.5 Safety Oversight}","confidence":1,"confidence_rate":1},{"cnt":[[307,1495],[1785,1495],[1785,1540],[307,1540]],"region":{"top_left_x":307,"top_left_y":1495,"width":1479,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54d174a2936c4593b46f52cdc09d35e8","type":"text","conversion_output":true,"text":"An independent DSMB will be established by NIAID to monitor safety data. The DSMB","text_display":"\n\nAn independent DSMB will be established by NIAID to monitor safety data. The DSMB","confidence":1,"confidence_rate":1},{"cnt":[[307,1547],[1678,1547],[1678,1592],[307,1592]],"region":{"top_left_x":307,"top_left_y":1546,"width":1371,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51a12c2ce32a4e4f9c97cf6a158cfcee","type":"text","conversion_output":true,"text":"will operate under the rules of a DMID-approved charter that will be written at the","text_display":" will operate under the rules of a DMID-approved charter that will be written at the","confidence":1,"confidence_rate":1},{"cnt":[[309,1594],[1712,1594],[1712,1641],[309,1641]],"region":{"top_left_x":309,"top_left_y":1594,"width":1404,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af90018c62554430b8a073dd33c78b9f","type":"text","conversion_output":true,"text":"organization meeting of the DSMB. At this time, each data element that the DSMB","text_display":" organization meeting of the DSMB. At this time, each data element that the DSMB","confidence":1,"confidence_rate":1},{"cnt":[[309,1646],[1798,1646],[1798,1691],[309,1691]],"region":{"top_left_x":309,"top_left_y":1645,"width":1490,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3321c5a1c7a4a2aa6199a1cabb66fa6","type":"text","conversion_output":true,"text":"needs to assess safety will be clearly defined. There will be several safety data reviews","text_display":" needs to assess safety will be clearly defined. 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In addition","text_display":" 125 , 250 and 350 patients have enrolled and completed the final TOC visit. 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In the patients with simple or uncomplicated bacteremia, there is evidence that the","text_display":"\n1. 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Based on the number of days of antibiotic use, a superiority","confidence":0.99951171875,"confidence_rate":0.9999945733425232},{"cnt":[[309,1216],[1253,1216],[1253,1261],[309,1261]],"region":{"top_left_x":309,"top_left_y":1216,"width":944,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5c6bce97f56479fa55f25c8bfbf1727","type":"text","conversion_output":true,"text":"hypothesis will be tested at the \\(5 \\%\\) level of significance.","text_display":" hypothesis will be tested at the \\(5 \\%\\) level of significance.","confidence":0.9990234375,"confidence_rate":0.9999851964785456},{"cnt":[[309,1328],[1094,1328],[1094,1388],[309,1388]],"region":{"top_left_x":309,"top_left_y":1327,"width":785,"height":61},"line":23,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"13eb30750d3c4930b19bd70624c539a6","type":"section_header","conversion_output":false,"children_ids":["7f80973e290e44f6a426ca4caeb3bbb0"],"text":"","text_display":""},{"cnt":[[314,1332],[1089,1332],[1089,1386],[314,1386]],"region":{"top_left_x":313,"top_left_y":1332,"width":777,"height":54},"line":24,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"7f80973e290e44f6a426ca4caeb3bbb0","type":"text","conversion_output":true,"parent_id":"13eb30750d3c4930b19bd70624c539a6","text":"11.2 Sample Size Considerations","text_display":"\n\n\\subsection*{11.2 Sample Size Considerations}","confidence":0.9458527565002441,"confidence_rate":0.9984548513464866},{"cnt":[[305,1431],[758,1431],[758,1485],[305,1485]],"region":{"top_left_x":305,"top_left_y":1430,"width":454,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea2221c5eabc4a99bb1bbc8a0445d9da","type":"section_header","conversion_output":false,"children_ids":["bbd34d78454840fc9be8f77a6c1e642c"],"text":"","text_display":""},{"cnt":[[309,1435],[754,1435],[754,1480],[309,1480]],"region":{"top_left_x":309,"top_left_y":1435,"width":446,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbd34d78454840fc9be8f77a6c1e642c","type":"text","conversion_output":true,"parent_id":"ea2221c5eabc4a99bb1bbc8a0445d9da","text":"11.2.1 Assumptions","text_display":"\n\n\\subsection*{11.2.1 Assumptions}","confidence":1,"confidence_rate":1},{"cnt":[[307,1521],[1803,1521],[1803,1568],[307,1568]],"region":{"top_left_x":307,"top_left_y":1521,"width":1496,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e979004fe45e40ca8dd954d95604fb3d","type":"text","conversion_output":true,"text":"With a sample size of 500 patients (i.e., 362 patients after \\(28 \\%\\) dropout), we would have","text_display":"\n\nWith a sample size of 500 patients (i.e., 362 patients after \\(28 \\%\\) dropout), we would have","confidence":1,"confidence_rate":1},{"cnt":[[309,1573],[1671,1573],[1671,1618],[309,1618]],"region":{"top_left_x":309,"top_left_y":1572,"width":1363,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e533f0913725469ca054d0fc8233802d","type":"text","conversion_output":true,"text":"at least 90\\% power for establishing non-inferiority based on two-sided test at 5\\%","text_display":" at least 90\\% power for establishing non-inferiority based on two-sided test at 5\\%","confidence":0.69580078125,"confidence_rate":0.9957915329235807},{"cnt":[[309,1624],[1757,1624],[1757,1669],[309,1669]],"region":{"top_left_x":309,"top_left_y":1624,"width":1449,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5fe15e7df25451e82cf7e60dd8a1518","type":"text","conversion_output":true,"text":"assuming that (1) equal cure rate of \\(75 \\%\\) and (2) a non-inferiority margin of \\(15 \\%\\). See","text_display":" assuming that (1) equal cure rate of \\(75 \\%\\) and (2) a non-inferiority margin of \\(15 \\%\\). See","confidence":0.96337890625,"confidence_rate":0.9996154504515739},{"cnt":[[309,1671],[1760,1671],[1760,1721],[309,1721]],"region":{"top_left_x":309,"top_left_y":1671,"width":1451,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e17b4281b83d4a09be62799df8a49466","type":"text","conversion_output":true,"text":"Table 3 below. In order to validate these assumptions, and to confirm the appropriate","text_display":" Table 3 below. In order to validate these assumptions, and to confirm the appropriate","confidence":0.99853515625,"confidence_rate":0.9999842375685026},{"cnt":[[309,1723],[1785,1723],[1785,1768],[309,1768]],"region":{"top_left_x":309,"top_left_y":1723,"width":1477,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94c9ad0068934c90b9d5538e5282ec9b","type":"text","conversion_output":true,"text":"target number of patients, a blinded sample size re-estimation was performed after 250","text_display":" target number of patients, a blinded sample size re-estimation was performed after 250","confidence":1,"confidence_rate":1},{"cnt":[[309,1775],[1815,1775],[1815,1820],[309,1820]],"region":{"top_left_x":309,"top_left_y":1774,"width":1507,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b70a5af0a8284b58bb44a29e57f999af","type":"text","conversion_output":true,"text":"patients were enrolled and completed the TOC visit DSMB's recommendation for sample","text_display":" patients were enrolled and completed the TOC visit DSMB's recommendation for sample","confidence":1,"confidence_rate":1},{"cnt":[[309,1824],[1687,1824],[1687,1869],[309,1869]],"region":{"top_left_x":309,"top_left_y":1824,"width":1378,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a6fded785f1482b916e8d5865505cdc","type":"text","conversion_output":true,"text":"size increase was made based on a conservative sensitivity analysis approach to","text_display":" size increase was made based on a conservative sensitivity analysis approach to","confidence":1,"confidence_rate":1},{"cnt":[[309,1873],[1755,1873],[1755,1919],[309,1919]],"region":{"top_left_x":309,"top_left_y":1873,"width":1447,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81ef13c55e8d472fb00ac8763e9f6d02","type":"text","conversion_output":true,"text":"account for variability associated with the observed difference in cure rates at interim.","text_display":" account for variability associated with the observed difference in cure rates at interim.","confidence":1,"confidence_rate":1},{"cnt":[[309,1925],[1745,1925],[1745,1970],[309,1970]],"region":{"top_left_x":309,"top_left_y":1925,"width":1436,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad21a39d6d5d42cf93f517414eabc9df","type":"text","conversion_output":true,"text":"This recommendation will be confirmed at the next blinded sample size re-estimation","text_display":" This recommendation will be confirmed at the next blinded sample size re-estimation","confidence":1,"confidence_rate":1},{"cnt":[[309,1972],[1775,1972],[1775,2022],[309,2022]],"region":{"top_left_x":309,"top_left_y":1972,"width":1466,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1b0c8b6afb746a49c7dd055f67de6c0","type":"text","conversion_output":true,"text":"when 350 patients have been enrolled and completed the TOC visit.. The sample size","text_display":" when 350 patients have been enrolled and completed the TOC visit.. The sample size","confidence":1,"confidence_rate":1},{"cnt":[[309,2024],[1798,2024],[1798,2069],[309,2069]],"region":{"top_left_x":309,"top_left_y":2023,"width":1490,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4180cde4d60b4a19b493fe3e5a75480b","type":"text","conversion_output":true,"text":"re-estimation will be reviewed by the DSMB. If the sample size re-estimation performed","text_display":" re-estimation will be reviewed by the DSMB. If the sample size re-estimation performed","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[309,2073],[1725,2073],[1725,2121],[309,2121]],"region":{"top_left_x":309,"top_left_y":2073,"width":1417,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"81ec8f167d9644bf87c29b1b190f9c00","type":"text","conversion_output":true,"text":"at 350 patients enrolled confirms that at least \\(80 \\%\\) power can be achieved, the total","text_display":" at 350 patients enrolled confirms that at least \\(80 \\%\\) power can be achieved, the total","confidence":0.99951171875,"confidence_rate":0.9999948589553403},{"cnt":[[309,2125],[1723,2125],[1723,2172],[309,2172]],"region":{"top_left_x":309,"top_left_y":2124,"width":1415,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b918517c738a4f878d024cf01aecc7fa","type":"text","conversion_output":true,"text":"patient target may adjusted In the unlikely event that at least \\(80 \\%\\) power cannot be","text_display":" patient target may adjusted In the unlikely event that at least \\(80 \\%\\) power cannot be","confidence":0.9980475902557373,"confidence_rate":0.9999785242066455},{"cnt":[[309,2174],[1760,2174],[1760,2221],[309,2221]],"region":{"top_left_x":309,"top_left_y":2174,"width":1451,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9cc76a21c544d87ab03907ca7f5637d","type":"text","conversion_output":true,"text":"achieved with 500 patients enrolled, the DSMB will provide recommendations and the","text_display":" achieved with 500 patients enrolled, the DSMB will provide recommendations and the","confidence":1,"confidence_rate":1},{"cnt":[[309,2226],[1467,2226],[1467,2271],[309,2271]],"region":{"top_left_x":309,"top_left_y":2225,"width":1159,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"108e16e7b1bb48b89b43fff9f8e55440","type":"text","conversion_output":true,"text":"Executive Committee will determine an appropriate course of action.","text_display":" Executive Committee will determine an appropriate course of action.","confidence":0.9990234375,"confidence_rate":0.9999864300969632},{"cnt":[[305,2314],[973,2314],[973,2370],[305,2370]],"region":{"top_left_x":305,"top_left_y":2313,"width":669,"height":57},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"019e55c77e1c452484a56b848af412d8","type":"section_header","conversion_output":false,"children_ids":["252bbb179f794529a97adff0b7b00b09"],"text":"","text_display":""},{"cnt":[[309,2316],[969,2316],[969,2365],[309,2365]],"region":{"top_left_x":309,"top_left_y":2316,"width":660,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"252bbb179f794529a97adff0b7b00b09","type":"text","conversion_output":true,"parent_id":"019e55c77e1c452484a56b848af412d8","text":"11.2.2 Sample Size Calculation","text_display":"\n\n\\subsection*{11.2.2 Sample Size Calculation}","confidence":1,"confidence_rate":1},{"cnt":[[309,2406],[1772,2406],[1772,2451],[309,2451]],"region":{"top_left_x":309,"top_left_y":2406,"width":1464,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"095ad5698609498bb1683b895f765613","type":"text","conversion_output":true,"text":"Sample size calculation was performed based on the primary study endpoint of clinical","text_display":"\n\nSample size calculation was performed based on the primary study endpoint of clinical","confidence":1,"confidence_rate":1},{"cnt":[[309,2454],[1815,2454],[1815,2503],[309,2503]],"region":{"top_left_x":309,"top_left_y":2453,"width":1507,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cda5f5b1a0d741a799e89f84d65e9d2a","type":"text","conversion_output":true,"text":"outcome (cure rate). The proposed study is powered to establish non-inferiority in clinical","text_display":" outcome (cure rate). The proposed study is powered to establish non-inferiority in clinical","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfac027d64114643b5b0c709a28df749","type":"page_info","conversion_output":false,"text":"65","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-080","page":80,"lines":[{"cnt":[[305,125],[1119,125],[1119,165],[305,165]],"region":{"top_left_x":305,"top_left_y":124,"width":815,"height":42},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3169a3eb713641d8ad19c1d1e4c4188d","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus 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There will be several safety data reviews after","confidence":1,"confidence_rate":1},{"cnt":[[312,1027],[1222,1027],[1222,1072],[312,1072]],"region":{"top_left_x":311,"top_left_y":1026,"width":912,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12a982477403498391102e67f8922132","type":"text","conversion_output":true,"text":"125,250 and 350 patients have enrolled in the study.","text_display":" 125,250 and 350 patients have enrolled in the study.","confidence":0.5298401489505977,"confidence_rate":0.9892919819881075},{"cnt":[[309,1119],[1785,1119],[1785,1164],[309,1164]],"region":{"top_left_x":309,"top_left_y":1119,"width":1477,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51b256e90a144bdcb47b098c361bf398","type":"text","conversion_output":true,"text":"Safety and efficacy data with written summaries will be generated and sent to DMID for","text_display":"\n\nSafety and efficacy data with written summaries will be generated and sent to DMID for","confidence":1,"confidence_rate":1},{"cnt":[[309,1169],[672,1169],[672,1214],[309,1214]],"region":{"top_left_x":309,"top_left_y":1168,"width":364,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76f9c9ebd2914c87aec0a140028df9fa","type":"text","conversion_output":true,"text":"the final study report.","text_display":" the final study report.","confidence":1,"confidence_rate":1},{"cnt":[[309,1280],[1025,1280],[1025,1343],[309,1343]],"region":{"top_left_x":309,"top_left_y":1280,"width":716,"height":63},"line":21,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f05cfb129541470399b184f602aaa09a","type":"section_header","conversion_output":false,"children_ids":["f6b891d16eed4540a078f83c0c90d518"],"text":"","text_display":""},{"cnt":[[314,1285],[1021,1285],[1021,1338],[314,1338]],"region":{"top_left_x":313,"top_left_y":1284,"width":708,"height":55},"line":22,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"f6b891d16eed4540a078f83c0c90d518","type":"text","conversion_output":true,"parent_id":"f05cfb129541470399b184f602aaa09a","text":"15.5 Study Records Retention","text_display":"\n\n\\subsection*{15.5 Study Records Retention}","confidence":1,"confidence_rate":1},{"cnt":[[309,1388],[1669,1388],[1669,1433],[309,1433]],"region":{"top_left_x":309,"top_left_y":1387,"width":1361,"height":47},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f9f61688be541c4a149af284cb50ec1","type":"text","conversion_output":true,"text":"It is recommended that investigators retain all records and documents (including","text_display":"\n\nIt is recommended that investigators retain all records and documents (including","confidence":1,"confidence_rate":1},{"cnt":[[309,1439],[1738,1439],[1738,1482],[309,1482]],"region":{"top_left_x":309,"top_left_y":1439,"width":1430,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d2b3fb8be444aaa99a2481af31931aa","type":"text","conversion_output":true,"text":"electronic data capture materials) pertaining to the conduct of the study for at least 6","text_display":" electronic data capture materials) pertaining to the conduct of the study for at least 6","confidence":0.99951171875,"confidence_rate":0.9999946913130248},{"cnt":[[309,1487],[1815,1487],[1815,1532],[309,1532]],"region":{"top_left_x":309,"top_left_y":1486,"width":1507,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdd942cf50a048759ce543c13db11723","type":"text","conversion_output":true,"text":"years after submission of the final study report in the event follow up is necessary to help","text_display":" years after submission of the final study report in the event follow up is necessary to help","confidence":1,"confidence_rate":1},{"cnt":[[309,1538],[1652,1538],[1652,1583],[309,1583]],"region":{"top_left_x":309,"top_left_y":1538,"width":1344,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e89074e14d4846cb9b7c15a597670fc6","type":"text","conversion_output":true,"text":"determine any potential hazards to patients who took part in these studies. The","text_display":" determine any potential hazards to patients who took part in these studies. The","confidence":1,"confidence_rate":1},{"cnt":[[309,1590],[1781,1590],[1781,1635],[309,1635]],"region":{"top_left_x":309,"top_left_y":1589,"width":1473,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e8d012a65de489195e2d0e5095e3962","type":"text","conversion_output":true,"text":"investigator agrees to obtain DMID agreement prior to disposal, moving, or transferring","text_display":" investigator agrees to obtain DMID agreement prior to disposal, moving, or transferring","confidence":1,"confidence_rate":1},{"cnt":[[309,1637],[1721,1637],[1721,1687],[309,1687]],"region":{"top_left_x":309,"top_left_y":1637,"width":1412,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ac7162f59284487b888d70c79ec237e","type":"text","conversion_output":true,"text":"of any study-related records. Additionally, if the investigator retires, relocates, or for","text_display":" of any study-related records. Additionally, if the investigator retires, relocates, or for","confidence":1,"confidence_rate":1},{"cnt":[[309,1689],[1764,1689],[1764,1734],[309,1734]],"region":{"top_left_x":309,"top_left_y":1688,"width":1455,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c98b9c10986e43f59095c14111fcc1da","type":"text","conversion_output":true,"text":"other reasons withdraws from the responsibility of the study, then another investigator","text_display":" other reasons withdraws from the responsibility of the study, then another investigator","confidence":1,"confidence_rate":1},{"cnt":[[309,1740],[1768,1740],[1768,1785],[309,1785]],"region":{"top_left_x":309,"top_left_y":1740,"width":1460,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"860f5504d3ad424487f1d78aac9aacf7","type":"text","conversion_output":true,"text":"must be assigned if the study is still active. Any new investigator must be approved by","text_display":" must be assigned if the study is still active. Any new investigator must be approved by","confidence":1,"confidence_rate":1},{"cnt":[[309,1788],[604,1788],[604,1828],[309,1828]],"region":{"top_left_x":309,"top_left_y":1787,"width":295,"height":42},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c2ce46f1b5e48cf8e660b0d82645103","type":"text","conversion_output":true,"text":"DMID and DCRI.","text_display":" DMID and DCRI.","confidence":1,"confidence_rate":1},{"cnt":[[309,1882],[1813,1882],[1813,1927],[309,1927]],"region":{"top_left_x":309,"top_left_y":1882,"width":1505,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e77b22a4171b464a8f1a7f72b48ef3ee","type":"text","conversion_output":true,"text":"Data generated by the methods described in the protocol will be recorded in the patient's","text_display":"\n\nData generated by the methods described in the protocol will be recorded in the patient's","confidence":0.9990236759185791,"confidence_rate":0.9999896085540316},{"cnt":[[309,1929],[1772,1929],[1772,1979],[309,1979]],"region":{"top_left_x":309,"top_left_y":1929,"width":1464,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22d9bac966de4a8389e57ba5ef34de28","type":"text","conversion_output":true,"text":"medical records and/or study progress notes. Data may be transcribed legibly on case","text_display":" medical records and/or study progress notes. Data may be transcribed legibly on case","confidence":1,"confidence_rate":1},{"cnt":[[309,1981],[1749,1981],[1749,2026],[309,2026]],"region":{"top_left_x":309,"top_left_y":1980,"width":1440,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41e4cd75c8cb407f817ad8944899e389","type":"text","conversion_output":true,"text":"report forms supplied for each patient or directly inputted into an electronic system or","text_display":" report forms supplied for each patient or directly inputted into an electronic system or","confidence":1,"confidence_rate":1},{"cnt":[[309,2030],[1680,2030],[1680,2078],[309,2078]],"region":{"top_left_x":309,"top_left_y":2030,"width":1372,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67e4e628cf7149908686a19616fb0b10","type":"text","conversion_output":true,"text":"any combination thereof. The investigator and DCRI will mutually agree upon the","text_display":" any combination thereof. The investigator and DCRI will mutually agree upon the","confidence":1,"confidence_rate":1},{"cnt":[[309,2082],[1154,2082],[1154,2127],[309,2127]],"region":{"top_left_x":309,"top_left_y":2081,"width":845,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12c5cb17a7b64d338aa00a6c36d2b1d4","type":"text","conversion_output":true,"text":"storage format for the retention of electronic data.","text_display":" storage format for the retention of electronic data.","confidence":1,"confidence_rate":1},{"cnt":[[309,2172],[1790,2172],[1790,2219],[309,2219]],"region":{"top_left_x":309,"top_left_y":2172,"width":1481,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd2421401fa1409fbb82385d2ba0dd81","type":"text","conversion_output":true,"text":"The investigator will agree to provide access to the office, clinic, and/or hospital records","text_display":"\n\nThe investigator will agree to provide access to the office, clinic, and/or hospital records","confidence":1,"confidence_rate":1},{"cnt":[[309,2221],[1794,2221],[1794,2271],[309,2271]],"region":{"top_left_x":309,"top_left_y":2221,"width":1485,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91a5f05e884f429e84f48cbd3b9c7ab8","type":"text","conversion_output":true,"text":"of all patients entered in this study. Access inspection of these records may be required","text_display":" of all patients entered in this study. Access inspection of these records may be required","confidence":1,"confidence_rate":1},{"cnt":[[309,2273],[1798,2273],[1798,2318],[309,2318]],"region":{"top_left_x":309,"top_left_y":2273,"width":1490,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e39df001adf649ff95a8f2cc56f1127a","type":"text","conversion_output":true,"text":"by the DCRI, DMID, and/or their representative(s) at the time of each monitoring visit. In","text_display":" by the DCRI, DMID, and/or their representative(s) at the time of each monitoring visit. In","confidence":1,"confidence_rate":1},{"cnt":[[309,2325],[1678,2325],[1678,2370],[309,2370]],"region":{"top_left_x":309,"top_left_y":2324,"width":1369,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f937506523d4e1ca3d4f1c55a08d159","type":"text","conversion_output":true,"text":"addition, all records may be subject to inspection by other health authorities. The","text_display":" addition, all records may be subject to inspection by other health authorities. The","confidence":1,"confidence_rate":1},{"cnt":[[309,2372],[1818,2372],[1818,2419],[309,2419]],"region":{"top_left_x":309,"top_left_y":2371,"width":1509,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f88ed721ff34c57b5ef1423c7802c4d","type":"text","conversion_output":true,"text":"investigator shall make accurate and adequate written progress reports to the IRB/IEC at","text_display":" investigator shall make accurate and adequate written progress reports to the IRB/IEC at","confidence":1,"confidence_rate":1},{"cnt":[[309,2423],[1777,2423],[1777,2469],[309,2469]],"region":{"top_left_x":309,"top_left_y":2423,"width":1468,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52e92b716ed24953aa13520ad6631c12","type":"text","conversion_output":true,"text":"appropriate intervals, not exceeding one year. The investigator shall make an accurate","text_display":" appropriate intervals, not exceeding one year. The investigator shall make an accurate","confidence":0.99951171875,"confidence_rate":0.9999946329759618},{"cnt":[[1038,2582],[1083,2582],[1083,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":46,"height":46},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4d2b56ca057b49ca97a7985b4293644d","type":"page_info","conversion_output":false,"text":"81","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"854f8d14-1f9a-48b9-9837-0a23578c0baf-096","page":96,"lines":[{"cnt":[[309,125],[1119,125],[1119,163],[309,163]],"region":{"top_left_x":309,"top_left_y":124,"width":811,"height":40},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"657212446c684a0db7087491e3275c09","type":"page_info","conversion_output":false,"text":"Algorithm-based Treatment of Staphylococcus 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2014","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[309,254],[1665,254],[1665,296],[309,296]],"region":{"top_left_x":309,"top_left_y":253,"width":1357,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46b0f604e6ed414897873c6739fa2822","type":"text","conversion_output":true,"text":"and adequate final report to the IRB/IEC within three months after completion or","text_display":"\nand adequate final report to the IRB/IEC within three months after completion or","confidence":1,"confidence_rate":1},{"cnt":[[309,303],[720,303],[720,346],[309,346]],"region":{"top_left_x":309,"top_left_y":302,"width":411,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"446f52a6ebc84c47be75e62600984549","type":"text","conversion_output":true,"text":"termination of the study.","text_display":" termination of the study.","confidence":1,"confidence_rate":1},{"cnt":[[309,417],[896,417],[896,466],[309,466]],"region":{"top_left_x":309,"top_left_y":416,"width":587,"height":51},"line":6,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"d8a418d23a6544aa9943c557a1294b1d","type":"section_header","conversion_output":false,"children_ids":["95d912b58aa74f70a9c59f7a1522b821"],"text":"","text_display":""},{"cnt":[[314,419],[896,419],[896,466],[314,466]],"region":{"top_left_x":313,"top_left_y":418,"width":583,"height":49},"line":7,"column":0,"font_size":44,"is_printed":true,"is_handwritten":false,"id":"95d912b58aa74f70a9c59f7a1522b821","type":"text","conversion_output":true,"parent_id":"d8a418d23a6544aa9943c557a1294b1d","text":"15.6 Protocol Deviations","text_display":"\n\n\\subsection*{15.6 Protocol Deviations}","confidence":0.99951171875,"confidence_rate":0.999983158745329},{"cnt":[[309,520],[1772,520],[1772,565],[309,565]],"region":{"top_left_x":309,"top_left_y":519,"width":1464,"height":47},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b74d9647d80148f9842e240ef10243d8","type":"text","conversion_output":true,"text":"A protocol deviation is defined as an event where the investigator or site personnel did","text_display":"\n\nA protocol deviation is defined as an event where the investigator or site personnel did","confidence":1,"confidence_rate":1},{"cnt":[[309,571],[1115,571],[1115,614],[309,614]],"region":{"top_left_x":309,"top_left_y":571,"width":807,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80935c677a904b16bde450cb05924587","type":"text","conversion_output":true,"text":"not conduct the study according to the protocol.","text_display":" not conduct the study according to the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[309,662],[1717,662],[1717,707],[309,707]],"region":{"top_left_x":309,"top_left_y":661,"width":1408,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0b79878eac6414795816d914aec7869","type":"text","conversion_output":true,"text":"Investigators are required to obtain prior approval from the Clinical Medical Monitor","text_display":"\n\nInvestigators are required to obtain prior approval from the Clinical Medical Monitor","confidence":1,"confidence_rate":1},{"cnt":[[309,713],[1781,713],[1781,758],[309,758]],"region":{"top_left_x":309,"top_left_y":713,"width":1473,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"293a7cf424af4e3bb24cc7d1013fa485","type":"text","conversion_output":true,"text":"before initiating deviations from the protocol, except where necessary to protect the life","text_display":" before initiating deviations from the protocol, except where necessary to protect the life","confidence":1,"confidence_rate":1},{"cnt":[[309,763],[1699,763],[1699,806],[309,806]],"region":{"top_left_x":309,"top_left_y":762,"width":1391,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"710e37f47a0c472dadfb06054ee0061e","type":"text","conversion_output":true,"text":"or physical well-being of a patient in an emergency. Prior approval is generally not","text_display":" or physical well-being of a patient in an emergency. 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