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The infant has received any infant formula other than Nutramigen prior to randomization","confidence":1,"confidence_rate":1},{"cnt":[[185,1633],[1055,1633],[1055,1682],[185,1682]],"region":{"top_left_x":184,"top_left_y":1632,"width":871,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4346d51b8d0b44c98380f60af644f5a5","type":"text","conversion_output":true,"text":"8. The infant is older than 7 days at randomization","text_display":"\n8. The infant is older than 7 days at randomization","confidence":1,"confidence_rate":1},{"cnt":[[180,1680],[1068,1680],[1068,1729],[180,1729]],"region":{"top_left_x":180,"top_left_y":1680,"width":888,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f1e90b5f7a54913a99220c960b63de0","type":"text","conversion_output":true,"text":"9. No HLA sample drawn before the age of 8 days","text_display":"\n9. 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The data on the","text_display":" parents and progression to clinical disease in such young first-degree relatives. The data on the","confidence":1,"confidence_rate":1},{"cnt":[[183,2065],[1940,2065],[1940,2116],[183,2116]],"region":{"top_left_x":182,"top_left_y":2064,"width":1759,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eeb32dce394c4392b26bfe8d6bde5221","type":"text","conversion_output":true,"text":"frequency of multiple ( \\(\\geq 2\\) ) autoantibodies by the age of 6 years and the cumulative incidence of type 1","text_display":" frequency of multiple ( \\(\\geq 2\\) ) autoantibodies by the age of 6 years and the cumulative incidence of type 1","confidence":0.9640386480340768,"confidence_rate":0.9996787893723977},{"cnt":[[183,2110],[1944,2110],[1944,2161],[183,2161]],"region":{"top_left_x":182,"top_left_y":2109,"width":1763,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06376ce0104e4442ab0dd16c3ea42a66","type":"text","conversion_output":true,"text":"diabetes by the age of 10 years are based on 82 young siblings from the DiMe Study carrying increased","text_display":" diabetes by the age of 10 years are based on 82 young siblings from the DiMe Study carrying increased","confidence":1,"confidence_rate":1},{"cnt":[[183,2161],[1708,2161],[1708,2211],[183,2211]],"region":{"top_left_x":182,"top_left_y":2161,"width":1527,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5bf83e43cdf04173b75853577e25ed09","type":"text","conversion_output":true,"text":"genetic risk for type 1 diabetes as defined according to the criteria in the Pilot-2 trial (106).","text_display":" genetic risk for type 1 diabetes as defined according to the criteria in the Pilot-2 trial (106).","confidence":1,"confidence_rate":1},{"cnt":[[183,2299],[1944,2299],[1944,2348],[183,2348]],"region":{"top_left_x":182,"top_left_y":2298,"width":1763,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa9d425ec1ce4d88a72b23e7be455ddb","type":"text","conversion_output":true,"text":"Nineteen out of 325 offspring ( \\(5.9 \\%\\) ) with increased genetic risk according to the criteria used in the","text_display":"\n\nNineteen out of 325 offspring ( \\(5.9 \\%\\) ) with increased genetic risk according to the criteria used in the","confidence":0.7638263702392578,"confidence_rate":0.9976600048520645},{"cnt":[[183,2346],[1944,2346],[1944,2396],[183,2396]],"region":{"top_left_x":182,"top_left_y":2346,"width":1763,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d6046517ec3444496260a0ed92a5ea2","type":"text","conversion_output":true,"text":"Pilot-2 trial tested positive for at least one autoantibody by the age of 2.4 years in the German","text_display":" Pilot-2 trial tested positive for at least one autoantibody by the age of 2.4 years in the German","confidence":1,"confidence_rate":1},{"cnt":[[183,2393],[1944,2393],[1944,2443],[183,2443]],"region":{"top_left_x":182,"top_left_y":2393,"width":1763,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ef26ccd53a84584aed4008c0384f856","type":"text","conversion_output":true,"text":"BABYDIAB study (107). Seventeen of these 19 subjects ( \\(89 \\%\\) ) developed multiple autoantibodies","text_display":" BABYDIAB study (107). Seventeen of these 19 subjects ( \\(89 \\%\\) ) developed multiple autoantibodies","confidence":0.998046875,"confidence_rate":0.9999813807939509},{"cnt":[[183,2443],[1944,2443],[1944,2494],[183,2494]],"region":{"top_left_x":182,"top_left_y":2442,"width":1763,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdb8af76202b4cc8b776e538e966b0ee","type":"text","conversion_output":true,"text":"during prospective observation. Assuming a constant increase in autoantibody frequency from age 2 to","text_display":" during prospective observation. Assuming a constant increase in autoantibody frequency from age 2 to","confidence":1,"confidence_rate":1},{"cnt":[[1919,2587],[1942,2587],[1942,2628],[1919,2628]],"region":{"top_left_x":1918,"top_left_y":2586,"width":25,"height":42},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e90eb053dc0343a795c2428dd26170c6","type":"page_info","conversion_output":false,"text":"1","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-03","page":3,"lines":[{"cnt":[[804,125],[1317,125],[1317,174],[804,174]],"region":{"top_left_x":803,"top_left_y":124,"width":514,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dadc3e2bb6894ed3bc12745614eef7cf","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,296],[180,296]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41682e624ebc4939995d79b3492c467b","type":"text","conversion_output":true,"text":"age 6 years, the expected cumulative incidence of at least one antibody would be \\(14.8 \\%\\) and that of at","text_display":"\nage 6 years, the expected cumulative incidence of at least one antibody would be \\(14.8 \\%\\) and that of at","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1944,294],[1944,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1765,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a9dd7e4efa049a88e9581471fea6ef2","type":"text","conversion_output":true,"text":"least two antibodies \\(13.0 \\%\\) by the age of 6 , which is well within the \\(95 \\% CI\\) of the observed frequency","text_display":" least two antibodies \\(13.0 \\%\\) by the age of 6 , which is well within the \\(95 \\% CI\\) of the observed frequency","confidence":0.8816471608588472,"confidence_rate":0.9989330835656417},{"cnt":[[180,339],[1270,339],[1270,393],[180,393]],"region":{"top_left_x":180,"top_left_y":339,"width":1090,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0f17b2434ae406a960b311f25138fe6","type":"text","conversion_output":true,"text":"of \\(20.7 \\%\\) of multiple autoantibodies in the young DiMe siblings.","text_display":" of \\(20.7 \\%\\) of multiple autoantibodies in the young DiMe siblings.","confidence":1,"confidence_rate":1},{"cnt":[[180,464],[1944,464],[1944,518],[180,518]],"region":{"top_left_x":180,"top_left_y":464,"width":1765,"height":54},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"500a5e1983b445288760bb9186edee86","type":"text","conversion_output":true,"text":"The cumulative incidence of at least one autoantibody by the age of 4 years was \\(10.6 \\%\\) in siblings and","text_display":"\n\nThe cumulative incidence of at least one autoantibody by the age of 4 years was \\(10.6 \\%\\) in siblings and","confidence":0.914047430967715,"confidence_rate":0.999197886017006},{"cnt":[[180,511],[1944,511],[1944,565],[180,565]],"region":{"top_left_x":180,"top_left_y":511,"width":1765,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c091690f029947148b720bcab78ac932","type":"text","conversion_output":true,"text":"offspring of affected subjects in the DAISY study from Denver (108). The frequency reached \\(37.9 \\%\\) in","text_display":" offspring of affected subjects in the DAISY study from Denver (108). The frequency reached \\(37.9 \\%\\) in","confidence":1,"confidence_rate":1},{"cnt":[[180,561],[1944,561],[1944,612],[180,612]],"region":{"top_left_x":180,"top_left_y":560,"width":1765,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff9aae77d35f4e148ff23292844bc807","type":"text","conversion_output":true,"text":"those carrying the DR3/4, DQB1*0302 combination. Published data are not available allowing an","text_display":" those carrying the DR3/4, DQB1*0302 combination. Published data are not available allowing an","confidence":1,"confidence_rate":1},{"cnt":[[180,608],[1944,608],[1944,660],[180,660]],"region":{"top_left_x":180,"top_left_y":608,"width":1765,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcf881c97ac84ee89455842b738e42b2","type":"text","conversion_output":true,"text":"estimation of the frequency of at least one or at least two autoantibodies in subjects with increased","text_display":" estimation of the frequency of at least one or at least two autoantibodies in subjects with increased","confidence":1,"confidence_rate":1},{"cnt":[[180,657],[1944,657],[1944,709],[180,709]],"region":{"top_left_x":180,"top_left_y":657,"width":1765,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b860fa7002543dd855dd63c41854f6a","type":"text","conversion_output":true,"text":"genetic risk as defined in the Pilot-2 trial. Nevertheless a constant increase in the frequency of at least","text_display":" genetic risk as defined in the Pilot-2 trial. Nevertheless a constant increase in the frequency of at least","confidence":1,"confidence_rate":1},{"cnt":[[180,705],[1944,705],[1944,758],[180,758]],"region":{"top_left_x":180,"top_left_y":704,"width":1765,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22fb4495161b4543abb7006e36c9b246","type":"text","conversion_output":true,"text":"one autoantibody from age 4 to age 6 years, would result in an autoantibody prevalence of \\(15.9 \\%\\) by the","text_display":" one autoantibody from age 4 to age 6 years, would result in an autoantibody prevalence of \\(15.9 \\%\\) by the","confidence":0.998046875,"confidence_rate":0.9999831463934391},{"cnt":[[180,752],[1944,752],[1944,806],[180,806]],"region":{"top_left_x":180,"top_left_y":751,"width":1765,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64d6e804954243beb3f26a2846059cd7","type":"text","conversion_output":true,"text":"age of 6 years in siblings and offspring irrespective of HLA-defined genetic risk. The DiMe study was","text_display":" age of 6 years in siblings and offspring irrespective of HLA-defined genetic risk. The DiMe study was","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[180,801],[1775,801],[1775,853],[180,853]],"region":{"top_left_x":180,"top_left_y":801,"width":1595,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed97a18e84114c5190b3d73a70c3dab7","type":"text","conversion_output":true,"text":"used for the power calculation as it includes the largest long term follow-up of young relatives.","text_display":" used for the power calculation as it includes the largest long term follow-up of young relatives.","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[180,922],[1944,922],[1944,978],[180,978]],"region":{"top_left_x":180,"top_left_y":921,"width":1765,"height":57},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86504bc686c24ad7a410b8e46ae6de62","type":"text","conversion_output":true,"text":"The estimation that 2032 infants should be randomized for the trial (Table 1) is based on the following","text_display":"\n\nThe estimation that 2032 infants should be randomized for the trial (Table 1) is based on the following","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[180,973],[410,973],[410,1025],[180,1025]],"region":{"top_left_x":180,"top_left_y":973,"width":231,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"acb78e2c7f7444329167113d01c26cf8","type":"text","conversion_output":true,"text":"assumptions:","text_display":" assumptions:","confidence":1,"confidence_rate":1},{"cnt":[[185,1031],[681,1031],[681,1085],[185,1085]],"region":{"top_left_x":184,"top_left_y":1031,"width":498,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"004f685ea6a84798b63fb67d180399c2","type":"text","conversion_output":true,"text":"1. a confidence level of \\(95 \\%\\);","text_display":"\n1. a confidence level of \\(95 \\%\\);","confidence":1,"confidence_rate":1},{"cnt":[[180,1096],[677,1096],[677,1147],[180,1147]],"region":{"top_left_x":180,"top_left_y":1095,"width":497,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f952a97e9efb40fc89494e6d69acf2a0","type":"text","conversion_output":true,"text":"2. a statistical power of \\(80 \\%\\);","text_display":"\n2. a statistical power of \\(80 \\%\\);","confidence":1,"confidence_rate":1},{"cnt":[[180,1156],[1592,1156],[1592,1210],[180,1210]],"region":{"top_left_x":180,"top_left_y":1155,"width":1412,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be5dde4ede374cd99a41584b74a672b0","type":"text","conversion_output":true,"text":"3. a reduction of \\(40 \\%\\) in the hazard rate of type 1 diabetes in the intervention group;","text_display":"\n3. a reduction of \\(40 \\%\\) in the hazard rate of type 1 diabetes in the intervention group;","confidence":1,"confidence_rate":1},{"cnt":[[180,1216],[696,1216],[696,1274],[180,1274]],"region":{"top_left_x":180,"top_left_y":1216,"width":517,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c7b53e92ae347d5bb61e29d1f3bc0ba","type":"text","conversion_output":true,"text":"4. a drop-out rate of \\(20 \\%\\); and","text_display":"\n4. a drop-out rate of \\(20 \\%\\); and","confidence":0.99658203125,"confidence_rate":0.9999122135111631},{"cnt":[[180,1280],[1545,1280],[1545,1334],[180,1334]],"region":{"top_left_x":180,"top_left_y":1280,"width":1365,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1e93fbb5c5a48e1806309ba32d4681c","type":"text","conversion_output":true,"text":"5. a frequency of \\(10 \\%\\) of exclusive breast feeding (BF) up to the age of 6 months","text_display":"\n5. a frequency of \\(10 \\%\\) of exclusive breast feeding (BF) up to the age of 6 months","confidence":0.708690210711211,"confidence_rate":0.9962232292784536},{"cnt":[[180,1405],[1944,1405],[1944,1457],[180,1457]],"region":{"top_left_x":180,"top_left_y":1405,"width":1765,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"209b11d8de444d6fa7e2a6d5daee0aaf","type":"text","conversion_output":true,"text":"These figures represent a conservative estimate, since they are based on the lower \\(95 \\% CI (7.6 \\%)\\) of the","text_display":"\n\nThese figures represent a conservative estimate, since they are based on the lower \\(95 \\% CI (7.6 \\%)\\) of the","confidence":0.5702053171116859,"confidence_rate":0.9949968542652466},{"cnt":[[180,1452],[1944,1452],[1944,1506],[180,1506]],"region":{"top_left_x":180,"top_left_y":1452,"width":1765,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"245367477852410398d481d4a263abf8","type":"text","conversion_output":true,"text":"observed cumulative incidence of type 1 diabetes by the age of 10 years ( \\(15.4 \\%\\) ) in young siblings with","text_display":" observed cumulative incidence of type 1 diabetes by the age of 10 years ( \\(15.4 \\%\\) ) in young siblings with","confidence":0.996584415435791,"confidence_rate":0.9999710052424781},{"cnt":[[180,1502],[1944,1502],[1944,1553],[180,1553]],"region":{"top_left_x":180,"top_left_y":1501,"width":1765,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ab91c2906ac42dfa7c43a9af2d3f90c","type":"text","conversion_output":true,"text":"moderate (DQB1*0302/x) and slightly increased genetic risk (DQB1*02/y), and since the high risk","text_display":" moderate (DQB1*0302/x) and slightly increased genetic risk (DQB1*02/y), and since the high risk","confidence":0.994636058807373,"confidence_rate":0.9999462176585563},{"cnt":[[180,1549],[1944,1549],[1944,1601],[180,1601]],"region":{"top_left_x":180,"top_left_y":1549,"width":1765,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eae30c07c2c543908ca1badeee9f5a00","type":"text","conversion_output":true,"text":"(DQB1*02/0302) group was not considered in the calculations. In the Pilot-2 trial the prevalence of the","text_display":" (DQB1*02/0302) group was not considered in the calculations. In the Pilot-2 trial the prevalence of the","confidence":0.99365234375,"confidence_rate":0.9999410398096767},{"cnt":[[180,1594],[1944,1594],[1944,1648],[180,1648]],"region":{"top_left_x":180,"top_left_y":1594,"width":1765,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d832e0d6a67844619a44fcd4ad1a7fa0","type":"text","conversion_output":true,"text":"high risk genotype (DQB1*02/0302) was about two times higher (absolute frequency \\(20 \\%\\) ) among","text_display":" high risk genotype (DQB1*02/0302) was about two times higher (absolute frequency \\(20 \\%\\) ) among","confidence":0.39843177795410156,"confidence_rate":0.9908400206487917},{"cnt":[[180,1644],[1944,1644],[1944,1695],[180,1695]],"region":{"top_left_x":180,"top_left_y":1643,"width":1765,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"492556ae429842bebe3d875996b89fc3","type":"text","conversion_output":true,"text":"siblings of affected children than among offspring of affected parents. If also the young siblings carrying","text_display":" siblings of affected children than among offspring of affected parents. If also the young siblings carrying","confidence":1,"confidence_rate":1},{"cnt":[[180,1693],[1944,1693],[1944,1742],[180,1742]],"region":{"top_left_x":180,"top_left_y":1692,"width":1765,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"872e6eb69eae4908bc62f9c99ffdfd74","type":"text","conversion_output":true,"text":"the high risk genotype in the DiMe Study should be included in the group at risk, the lower 95\\% CI","text_display":" the high risk genotype in the DiMe Study should be included in the group at risk, the lower 95\\% CI","confidence":0.96142578125,"confidence_rate":0.9996181514904706},{"cnt":[[180,1740],[1944,1740],[1944,1790],[180,1790]],"region":{"top_left_x":180,"top_left_y":1740,"width":1765,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f87e49b20ae4d1887087f12c3ed72a0","type":"text","conversion_output":true,"text":"would be \\(10.6 \\%\\), which should result in a recommendation of 1920 infants to be randomized for the","text_display":" would be \\(10.6 \\%\\), which should result in a recommendation of 1920 infants to be randomized for the","confidence":0.9970703125,"confidence_rate":0.9999728338186853},{"cnt":[[180,1788],[1944,1788],[1944,1841],[180,1841]],"region":{"top_left_x":180,"top_left_y":1787,"width":1765,"height":55},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"128aadc303764de0a67aadc6554eb7d7","type":"text","conversion_output":true,"text":"trial. However, fewer data from non-Finnish populations are available, explaining the caution of this","text_display":" trial. However, fewer data from non-Finnish populations are available, explaining the caution of this","confidence":1,"confidence_rate":1},{"cnt":[[180,1835],[544,1835],[544,1888],[180,1888]],"region":{"top_left_x":180,"top_left_y":1834,"width":364,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f601c8606e03486fb21780355a71ba37","type":"text","conversion_output":true,"text":"sample size estimate.","text_display":" sample size estimate.","confidence":0.99755859375,"confidence_rate":0.9999059893676697},{"cnt":[[1912,2582],[1955,2582],[1955,2628],[1912,2628]],"region":{"top_left_x":1912,"top_left_y":2582,"width":44,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9fabc0fccb84f8aa3f3ef621727c8ea","type":"page_info","conversion_output":false,"text":"2","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-04","page":4,"lines":[{"cnt":[[808,125],[1315,125],[1315,174],[808,174]],"region":{"top_left_x":807,"top_left_y":124,"width":508,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8d92b3cbdaa4418a696a57f967655d1","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,322],[1027,322],[1027,372],[180,372]],"region":{"top_left_x":180,"top_left_y":322,"width":847,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80acfd88417c46bca80aebeb78772204","type":"figure_label","conversion_output":true,"text":"Table 1. Estimation of the sample size for the trial","text_display":"\n\nTable 1. Estimation of the sample size for the 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of exclusive BF up to the age of 6","text_display":"\nColumn III: Sample size corrected in addition for a \\(10 \\%\\) frequency of exclusive BF up to the age of 6","confidence":0.9485156731680036,"confidence_rate":0.9995323486256514},{"cnt":[[183,2037],[324,2037],[324,2082],[183,2082]],"region":{"top_left_x":182,"top_left_y":2036,"width":143,"height":46},"line":150,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40ce031eef214be5bd9c41754c8e3ba6","type":"text","conversion_output":true,"text":"months.","text_display":" months.","confidence":1,"confidence_rate":1},{"cnt":[[185,2101],[1038,2101],[1038,2142],[185,2142]],"region":{"top_left_x":184,"top_left_y":2101,"width":854,"height":41},"line":151,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f77c9c9250e4320b16f76a8187751d7","type":"text","conversion_output":true,"text":"RECOMMENDATION: 2032 infants and families","text_display":"\n\nRECOMMENDATION: 2032 infants and 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In all principal analyses, subjects will be included in the group","text_display":" subject will be employed in the analyses. In all principal analyses, subjects will be included in the group","confidence":1,"confidence_rate":1},{"cnt":[[1916,2587],[1942,2587],[1942,2628],[1916,2628]],"region":{"top_left_x":1916,"top_left_y":2586,"width":27,"height":42},"line":156,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2fc65da6b9754a43b7f67f5b02a6b87f","type":"page_info","conversion_output":false,"text":"3","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-05","page":5,"lines":[{"cnt":[[804,125],[1317,125],[1317,174],[804,174]],"region":{"top_left_x":803,"top_left_y":124,"width":514,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2b7f5c2d869410eb4105df50742c1e1","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,299],[180,299]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"046b7b1868304ce0a0e44bd70101266c","type":"text","conversion_output":true,"text":"to which they were initially assigned and this assignment will not be altered based on a subject's","text_display":"\nto which they were initially assigned and this assignment will not be altered based on a subject's","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1949,294],[1949,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1769,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b83ab5bbb0f94f5691c69a2e3e472eb9","type":"text","conversion_output":true,"text":"adherence to the assigned treatment program. Analyses of each outcome will include an assessment of","text_display":" adherence to the assigned treatment program. Analyses of each outcome will include an assessment of","confidence":1,"confidence_rate":1},{"cnt":[[180,344],[1944,344],[1944,393],[180,393]],"region":{"top_left_x":180,"top_left_y":343,"width":1765,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0b74dc6fb1143589a7f14a40b7800df","type":"text","conversion_output":true,"text":"possible differences among clinical centers. Baseline variables that will be used in stratified analyses","text_display":" possible differences among clinical centers. 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If","confidence":1,"confidence_rate":1},{"cnt":[[183,580],[1944,580],[1944,634],[183,634]],"region":{"top_left_x":182,"top_left_y":580,"width":1763,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"375c5a88210e45ddb15a3c371f4b91c8","type":"text","conversion_output":true,"text":"any more than a few baseline characteristics are identified, because of small sample size, it will be","text_display":" any more than a few baseline characteristics are identified, because of small sample size, it will be","confidence":1,"confidence_rate":1},{"cnt":[[180,627],[1944,627],[1944,681],[180,681]],"region":{"top_left_x":180,"top_left_y":627,"width":1765,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"370b6356340b4763934cd67cfd85431c","type":"text","conversion_output":true,"text":"necessary that regression models be employed to adjust the treatment comparison for the confounding","text_display":" necessary that regression models be employed to adjust the treatment comparison for the confounding","confidence":1,"confidence_rate":1},{"cnt":[[180,677],[1944,677],[1944,728],[180,728]],"region":{"top_left_x":180,"top_left_y":676,"width":1765,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa8bbe91c9cb42e7b95d1592ea88762d","type":"text","conversion_output":true,"text":"effects of those characteristics. A number of subgroup analyses are planned to help identify individuals","text_display":" effects of those characteristics. A number of subgroup analyses are planned to help identify individuals","confidence":1,"confidence_rate":1},{"cnt":[[180,726],[1944,726],[1944,778],[180,778]],"region":{"top_left_x":180,"top_left_y":726,"width":1765,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddbd201b196a4fb7b731f720af984408","type":"text","conversion_output":true,"text":"more likely to benefit from, or to be harmed by, the treatment. In regard to treatment effects, definition","text_display":" more likely to benefit from, or to be harmed by, the treatment. In regard to treatment effects, definition","confidence":1,"confidence_rate":1},{"cnt":[[180,773],[1944,773],[1944,827],[180,827]],"region":{"top_left_x":180,"top_left_y":773,"width":1765,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3df06dd4c4449a8aea233d8250f8dc7","type":"text","conversion_output":true,"text":"of such subgroups will rely on baseline data, not data measured after randomization. Such subgroups","text_display":" of such subgroups will rely on baseline data, not data measured after randomization. Such subgroups","confidence":1,"confidence_rate":1},{"cnt":[[180,821],[1944,821],[1944,874],[180,874]],"region":{"top_left_x":180,"top_left_y":820,"width":1765,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa292bc1ef34481996e86411a1a08d5f","type":"text","conversion_output":true,"text":"might include: gender, gender of the relative with type 1 diabetes, HLA risk group and other factors","text_display":" might include: gender, gender of the relative with type 1 diabetes, HLA risk group and other factors","confidence":1,"confidence_rate":1},{"cnt":[[180,868],[1944,868],[1944,922],[180,922]],"region":{"top_left_x":180,"top_left_y":867,"width":1765,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fbdfbf98c654e3da34aabd12b8e6479","type":"text","conversion_output":true,"text":"suspected to be associated with the event. Exploratory data derived through subgroup analyses will","text_display":" suspected to be associated with the event. Exploratory data derived through subgroup analyses will","confidence":1,"confidence_rate":1},{"cnt":[[180,915],[1944,915],[1944,969],[180,969]],"region":{"top_left_x":180,"top_left_y":915,"width":1765,"height":54},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f27a5e1c316a494388358c8f66a73cc3","type":"text","conversion_output":true,"text":"serve primarily to generate new hypotheses for subsequent testing, and conclusions drawn from","text_display":" serve primarily to generate new hypotheses for subsequent testing, and conclusions drawn from","confidence":1,"confidence_rate":1},{"cnt":[[180,967],[1944,967],[1944,1016],[180,1016]],"region":{"top_left_x":180,"top_left_y":966,"width":1765,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34d3682d52d9430eb842963ee87e329b","type":"text","conversion_output":true,"text":"subgroup hypotheses not explicitly stated before data analysis will have less credibility than those from","text_display":" subgroup hypotheses not explicitly stated before data analysis will have less credibility than those from","confidence":0.998046875,"confidence_rate":0.9999822271139778},{"cnt":[[180,1010],[1944,1010],[1944,1068],[180,1068]],"region":{"top_left_x":180,"top_left_y":1009,"width":1765,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c2876df60c0428a94784fe2f39e092b","type":"text","conversion_output":true,"text":"hypotheses stated in the protocol. For safety monitoring, the Data Management Unit also will perform","text_display":" hypotheses stated in the protocol. For safety monitoring, the Data Management Unit also will perform","confidence":1,"confidence_rate":1},{"cnt":[[180,1061],[1944,1061],[1944,1113],[180,1113]],"region":{"top_left_x":180,"top_left_y":1061,"width":1765,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55524d4f11914f28a84b6217b1af5852","type":"text","conversion_output":true,"text":"any and all analyses that are appropriate to identify subgroups that may be at significantly increased","text_display":" any and all analyses that are appropriate to identify subgroups that may be at significantly increased","confidence":1,"confidence_rate":1},{"cnt":[[180,1109],[1944,1109],[1944,1162],[180,1162]],"region":{"top_left_x":180,"top_left_y":1108,"width":1765,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f41849e5608d4b5dad06e4d53ee52b8f","type":"text","conversion_output":true,"text":"safety risk. The Kaplan-Meier method will be used to construct survival curves and the logrank statistic","text_display":" safety risk. The Kaplan-Meier method will be used to construct survival curves and the logrank statistic","confidence":1,"confidence_rate":1},{"cnt":[[180,1156],[1940,1156],[1940,1210],[180,1210]],"region":{"top_left_x":180,"top_left_y":1155,"width":1761,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60f7995ac7a640f78679f0ec05e07187","type":"text","conversion_output":true,"text":"used to compare treatment arms with respect to time until the development of autoimmunity or type 1","text_display":" used to compare treatment arms with respect to time until the development of autoimmunity or type 1","confidence":1,"confidence_rate":1},{"cnt":[[180,1203],[337,1203],[337,1253],[180,1253]],"region":{"top_left_x":180,"top_left_y":1203,"width":158,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2d5b010815d47b1a492783606af0686","type":"text","conversion_output":true,"text":"diabetes.","text_display":" diabetes.","confidence":1,"confidence_rate":1},{"cnt":[[180,1326],[1944,1326],[1944,1381],[180,1381]],"region":{"top_left_x":180,"top_left_y":1325,"width":1765,"height":57},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dc6ae91348e4d25beed3ac756a0c03d","type":"text","conversion_output":true,"text":"We therefore aim to randomize 2032 infants with increased genetic risk as defined in the genetic","text_display":"\n\nWe therefore aim to randomize 2032 infants with increased genetic risk as defined in the genetic","confidence":1,"confidence_rate":1},{"cnt":[[180,1375],[1949,1375],[1949,1429],[180,1429]],"region":{"top_left_x":180,"top_left_y":1375,"width":1769,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b345353c82924a4eac6aace39fd1077c","type":"text","conversion_output":true,"text":"screening section (E). To achieve that number 4516 infants must be screened assuming a frequency of","text_display":" screening section (E). To achieve that number 4516 infants must be screened assuming a frequency of","confidence":1,"confidence_rate":1},{"cnt":[[180,1422],[1944,1422],[1944,1476],[180,1476]],"region":{"top_left_x":180,"top_left_y":1422,"width":1765,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bca382e599e94031891d7bb5e3fd758b","type":"text","conversion_output":true,"text":"\\(45 \\%\\) of the genotypes conferring increased risk. The observed prevalence of risk genotypes was \\(50 \\%\\)","text_display":" \\(45 \\%\\) of the genotypes conferring increased risk. The observed prevalence of risk genotypes was \\(50 \\%\\)","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[180,1470],[1944,1470],[1944,1523],[180,1523]],"region":{"top_left_x":180,"top_left_y":1469,"width":1765,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fbe5fb59d1245a7bf1528a085bcc81e","type":"text","conversion_output":true,"text":"among the 471 infants screened for the Pilot-2 trial in Finland. An enrollment scheme for the trial proper","text_display":" among the 471 infants screened for the Pilot-2 trial in Finland. An enrollment scheme for the trial proper","confidence":1,"confidence_rate":1},{"cnt":[[180,1519],[1944,1517],[1944,1572],[180,1574]],"region":{"top_left_x":180,"top_left_y":1516,"width":1765,"height":59},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"449a8065af89452bb45c580f024512d3","type":"text","conversion_output":true,"text":"is presented in Figure 1. This flow sheet indicates that the trial requires initial access to 5806","text_display":" is presented in Figure 1. This flow sheet indicates that the trial requires initial access to 5806","confidence":1,"confidence_rate":1},{"cnt":[[180,1566],[1944,1566],[1944,1620],[180,1620]],"region":{"top_left_x":180,"top_left_y":1566,"width":1765,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37406279d79b4fa298be9a1e7ca698b3","type":"text","conversion_output":true,"text":"pregnancies. This should provide at least 4936 families with consent to participate in the trial before the","text_display":" pregnancies. This should provide at least 4936 families with consent to participate in the trial before the","confidence":1,"confidence_rate":1},{"cnt":[[180,1616],[1944,1616],[1944,1669],[180,1669]],"region":{"top_left_x":180,"top_left_y":1615,"width":1765,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b328cfb93e7e4a74af8b9a9eff9a5c2f","type":"text","conversion_output":true,"text":"birth of the child provided that the consent rate is \\(85 \\%\\). With an exclusion rate of \\(8.5 \\%\\) after birth based","text_display":" birth of the child provided that the consent rate is \\(85 \\%\\). With an exclusion rate of \\(8.5 \\%\\) after birth based","confidence":1,"confidence_rate":1},{"cnt":[[180,1663],[1944,1663],[1944,1717],[180,1717]],"region":{"top_left_x":180,"top_left_y":1662,"width":1765,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8605f54f7a68420cb024b5330efec3c3","type":"text","conversion_output":true,"text":"on the exclusion criteria approximately 4516 infants will be available for genetic screening. The","text_display":" on the exclusion criteria approximately 4516 infants will be available for genetic screening. The","confidence":1,"confidence_rate":1},{"cnt":[[180,1710],[1076,1710],[1076,1760],[180,1760]],"region":{"top_left_x":180,"top_left_y":1710,"width":897,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"270e4011481744e486d3e41a45103706","type":"text","conversion_output":true,"text":"observed exclusion rate in the Pilot-2 trial was \\(8.6 \\%\\).","text_display":" observed exclusion rate in the Pilot-2 trial was \\(8.6 \\%\\).","confidence":0.94091796875,"confidence_rate":0.9990338112240231},{"cnt":[[180,1818],[1949,1818],[1949,1876],[180,1876]],"region":{"top_left_x":180,"top_left_y":1817,"width":1769,"height":59},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcf2f8667b824695add046d75857def1","type":"text","conversion_output":true,"text":"Infants will be recruited over a four-year period and the planned follow-up will be 6 years after the last","text_display":"\n\nInfants will be recruited over a four-year period and the planned follow-up will be 6 years after the last","confidence":1,"confidence_rate":1},{"cnt":[[180,1869],[1946,1869],[1946,1923],[180,1923]],"region":{"top_left_x":180,"top_left_y":1869,"width":1767,"height":54},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a7fe4ac37bd411a98a65335cb55c062","type":"text","conversion_output":true,"text":"infant has been accrued for the antibody endpoint and 10 years after the last infant is accrued for the","text_display":" infant has been accrued for the antibody endpoint and 10 years after the last infant is accrued for the","confidence":1,"confidence_rate":1},{"cnt":[[180,1916],[1594,1916],[1594,1970],[180,1970]],"region":{"top_left_x":180,"top_left_y":1916,"width":1415,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3b9c8bf984947c09c475b1223b52e3c","type":"text","conversion_output":true,"text":"type 1 diabetes end point. Thus, all subjects will have at least 10 years of follow-up.","text_display":" type 1 diabetes end point. Thus, all subjects will have at least 10 years of follow-up.","confidence":1,"confidence_rate":1},{"cnt":[[1912,2582],[1955,2582],[1955,2628],[1912,2628]],"region":{"top_left_x":1912,"top_left_y":2582,"width":44,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b8d1857649549e292d02f44e521d9e0","type":"page_info","conversion_output":false,"text":"4","text_display":"","confidence":0.99951171875,"confidence_rate":0.99951171875}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-06","page":6,"lines":[{"cnt":[[808,125],[1315,125],[1315,174],[808,174]],"region":{"top_left_x":807,"top_left_y":124,"width":508,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"630da6f807fa4cdabf3435b3c44f3ec2","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,247],[879,247],[879,294],[180,294]],"region":{"top_left_x":180,"top_left_y":247,"width":699,"height":48},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03688e8ac63c4370b7ce2efffe5d46ec","type":"figure_label","conversion_output":false,"text":"Figure 1. Enrollment scheme for TRIGR","text_display":"","confidence":0.99951171875,"confidence_rate":0.9999883714843234},{"cnt":[[206,402],[1929,402],[1929,1577],[206,1577]],"region":{"top_left_x":206,"top_left_y":401,"width":1724,"height":1176},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83aa1324ca0a4a9ca87dae2143dcb3ff","type":"diagram","conversion_output":true,"selected_labels":["03688e8ac63c4370b7ce2efffe5d46ec"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1. Enrollment scheme for TRIGR}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-06.jpg?height=1176&width=1724&top_left_y=401&top_left_x=206}\n\\end{figure}"},{"cnt":[[855,1676],[1280,1676],[1280,1725],[855,1725]],"region":{"top_left_x":855,"top_left_y":1675,"width":426,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ab9ed512c944817adfbe06aed497493","type":"section_header","conversion_output":false,"children_ids":["18b913ed14f74fbabb92ceb8250ac5a6"],"text":"","text_display":""},{"cnt":[[855,1680],[1278,1680],[1278,1721],[855,1721]],"region":{"top_left_x":855,"top_left_y":1680,"width":424,"height":41},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18b913ed14f74fbabb92ceb8250ac5a6","type":"text","conversion_output":true,"parent_id":"1ab9ed512c944817adfbe06aed497493","text":"C. RECRUITMENT","text_display":"\n\n\\section*{C. RECRUITMENT}","confidence":1,"confidence_rate":1},{"cnt":[[183,1775],[1944,1775],[1944,1824],[183,1824]],"region":{"top_left_x":182,"top_left_y":1774,"width":1763,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebf8e93466594d219e08a75bdb02100d","type":"text","conversion_output":true,"text":"Recruitment is carried out in six major centers in USA, in 18 centers in Canada, in 12 European","text_display":"\n\nRecruitment is carried out in six major centers in USA, in 18 centers in Canada, in 12 European","confidence":0.9990234375,"confidence_rate":0.9999907826873115},{"cnt":[[183,1822],[1944,1822],[1944,1871],[183,1871]],"region":{"top_left_x":182,"top_left_y":1821,"width":1763,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be3514195e5546b9b5b55bc16cd8100e","type":"text","conversion_output":true,"text":"countries, and three centers in N.S.W., Australia. A list of participating countries and recruitment","text_display":" countries, and three centers in N.S.W., Australia. A list of participating countries and recruitment","confidence":1,"confidence_rate":1},{"cnt":[[183,1869],[1944,1869],[1944,1919],[183,1919]],"region":{"top_left_x":182,"top_left_y":1869,"width":1763,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c868f58062fe4a34ba5f91b6196e93f0","type":"text","conversion_output":true,"text":"estimates are presented in Appendix 1. The figures represent an estimate of eligible pregnant women","text_display":" estimates are presented in Appendix 1. The figures represent an estimate of eligible pregnant women","confidence":1,"confidence_rate":1},{"cnt":[[180,1919],[1944,1919],[1944,1966],[180,1966]],"region":{"top_left_x":180,"top_left_y":1918,"width":1765,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb7ca64d00d3442da7cd48ee4d5b1e84","type":"text","conversion_output":true,"text":"available in each country. The background of these estimates is that the appraisal of the acceptance rate","text_display":" available in each country. The background of these estimates is that the appraisal of the acceptance rate","confidence":1,"confidence_rate":1},{"cnt":[[183,1966],[1944,1966],[1944,2015],[183,2015]],"region":{"top_left_x":182,"top_left_y":1965,"width":1763,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6595153cef76440f9b93eff13d3b6f90","type":"text","conversion_output":true,"text":"(best scenario \\(70-80 \\%\\), average \\(60 \\%\\) ) may vary from country to country, and accordingly the total","text_display":" (best scenario \\(70-80 \\%\\), average \\(60 \\%\\) ) may vary from country to country, and accordingly the total","confidence":0.9936578260967508,"confidence_rate":0.9999410908932761},{"cnt":[[183,2015],[1944,2015],[1944,2065],[183,2065]],"region":{"top_left_x":182,"top_left_y":2015,"width":1763,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08147ee2ee6a44e19c0de3b600e9284e","type":"text","conversion_output":true,"text":"recruitment figures are a rough estimate. According to the figures given in Appendix 1 about \\(65 \\%\\) of the","text_display":" recruitment figures are a rough estimate. According to the figures given in Appendix 1 about \\(65 \\%\\) of the","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[180,2062],[1944,2062],[1944,2112],[180,2112]],"region":{"top_left_x":180,"top_left_y":2062,"width":1765,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"480fe4f8c10448c683dd6866c64ffc78","type":"text","conversion_output":true,"text":"participants will be recruited in North America and \\(35 \\%\\) in Europe + Australia. The recruitment will be","text_display":" participants will be recruited in North America and \\(35 \\%\\) in Europe + Australia. The recruitment will be","confidence":0.8130807876586914,"confidence_rate":0.9981704826502006},{"cnt":[[183,2110],[1944,2110],[1944,2159],[183,2159]],"region":{"top_left_x":182,"top_left_y":2109,"width":1763,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"115a751661ce44f9bb75055ca6314149","type":"text","conversion_output":true,"text":"continued past the initial 4 -year period, if we have not obtained 2,032 newborn infants with increased","text_display":" continued past the initial 4 -year period, if we have not obtained 2,032 newborn infants with increased","confidence":0.9059756726492196,"confidence_rate":0.9991342098839592},{"cnt":[[183,2157],[814,2157],[814,2206],[183,2206]],"region":{"top_left_x":182,"top_left_y":2157,"width":633,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1a6a2c821ef420590cb0ab52a461b6d","type":"text","conversion_output":true,"text":"genetic risk to the series by that time.","text_display":" genetic risk to the series by that time.","confidence":1,"confidence_rate":1},{"cnt":[[183,2254],[1944,2254],[1944,2303],[183,2303]],"region":{"top_left_x":182,"top_left_y":2253,"width":1763,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32e391f288654446a5e42b072095f938","type":"text","conversion_output":true,"text":"To facilitate recruitment and to minimize any possibility of unintentional exposure to CM protein, every","text_display":"\n\nTo facilitate recruitment and to minimize any possibility of unintentional exposure to CM protein, every","confidence":1,"confidence_rate":1},{"cnt":[[183,2303],[1944,2303],[1944,2350],[183,2350]],"region":{"top_left_x":182,"top_left_y":2303,"width":1763,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"007b67c41dd64c90b3d40ab474dccb39","type":"text","conversion_output":true,"text":"attempt is made to identify eligible families before the child is born. Written consent is obtained at this","text_display":" attempt is made to identify eligible families before the child is born. Written consent is obtained at this","confidence":1,"confidence_rate":1},{"cnt":[[180,2350],[1944,2350],[1944,2400],[180,2400]],"region":{"top_left_x":180,"top_left_y":2350,"width":1765,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddf453ccca2b4b94bed5b35687d1b11d","type":"text","conversion_output":true,"text":"time; the child will participate after birth if he/she meets the inclusion but not the exclusion criteria.","text_display":" time; the child will participate after birth if he/she meets the inclusion but not the exclusion criteria.","confidence":1,"confidence_rate":1},{"cnt":[[180,2398],[1944,2398],[1944,2447],[180,2447]],"region":{"top_left_x":180,"top_left_y":2397,"width":1765,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d0abcaebb8748ec9121b6b4f53f62b1","type":"text","conversion_output":true,"text":"Families not identified until just prior to the onset of maternal labor are approached after birth and","text_display":" Families not identified until just prior to the onset of maternal labor are approached after birth and","confidence":1,"confidence_rate":1},{"cnt":[[180,2445],[844,2445],[844,2490],[180,2490]],"region":{"top_left_x":180,"top_left_y":2444,"width":665,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64498c677c034e7b8f516c3c61d0499a","type":"text","conversion_output":true,"text":"written consent is obtained at that time.","text_display":" written consent is obtained at that time.","confidence":1,"confidence_rate":1},{"cnt":[[1916,2587],[1942,2587],[1942,2628],[1916,2628]],"region":{"top_left_x":1916,"top_left_y":2586,"width":27,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b7b2cbcdf6304309bd02cc511020d2da","type":"page_info","conversion_output":false,"text":"5","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-07","page":7,"lines":[{"cnt":[[808,125],[1315,125],[1315,174],[808,174]],"region":{"top_left_x":807,"top_left_y":124,"width":508,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21711de3a4794c59b9dba5d13a22d792","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1944,294],[1944,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1765,"height":52},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c866c84ed1b43049b094063f4120caf","type":"text","conversion_output":true,"text":"Mothers with type 1 diabetes are identified during pregnancy via hospitals monitoring pregnant women","text_display":"\n\nMothers with type 1 diabetes are identified during pregnancy via hospitals monitoring pregnant women","confidence":1,"confidence_rate":1},{"cnt":[[180,344],[1944,344],[1944,393],[180,393]],"region":{"top_left_x":180,"top_left_y":343,"width":1765,"height":51},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be444a632bac4971a1581023a9a939f1","type":"text","conversion_output":true,"text":"with type 1 diabetes. Fathers with type 1 diabetes are identified by (i) available history or data already","text_display":" with type 1 diabetes. Fathers with type 1 diabetes are identified by (i) available history or data already","confidence":1,"confidence_rate":1},{"cnt":[[183,391],[1944,391],[1944,440],[183,440]],"region":{"top_left_x":182,"top_left_y":391,"width":1763,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"839d3c6e8ee848a1bd1bdb39e4961a18","type":"text","conversion_output":true,"text":"in the medical records of pregnant women, (ii) interviewing women at prenatal maternity clinic visits,","text_display":" in the medical records of pregnant women, (ii) interviewing women at prenatal maternity clinic visits,","confidence":1,"confidence_rate":1},{"cnt":[[183,438],[1944,438],[1944,488],[183,488]],"region":{"top_left_x":182,"top_left_y":438,"width":1763,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afce39f613594e968ba3b101b52eca9e","type":"text","conversion_output":true,"text":"and (iii) existing registries of type 1 diabetes in some centers. Pregnant women already having one or","text_display":" and (iii) existing registries of type 1 diabetes in some centers. Pregnant women already having one or","confidence":1,"confidence_rate":1},{"cnt":[[183,486],[1944,486],[1944,535],[183,535]],"region":{"top_left_x":182,"top_left_y":485,"width":1763,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fc8c7bef7ef4b76911b9842a7170b7d","type":"text","conversion_output":true,"text":"more children affected with diabetes are approached through various diabetes clinics. Children with","text_display":" more children affected with diabetes are approached through various diabetes clinics. Children with","confidence":1,"confidence_rate":1},{"cnt":[[180,535],[1944,535],[1944,587],[180,587]],"region":{"top_left_x":180,"top_left_y":534,"width":1765,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be5b2f5dd83f445cb1b8fb4b3917e081","type":"text","conversion_output":true,"text":"type 1 diabetes are usually followed by pediatricians or pediatric endocrinologists, who are aware of a","text_display":" type 1 diabetes are usually followed by pediatricians or pediatric endocrinologists, who are aware of a","confidence":1,"confidence_rate":1},{"cnt":[[180,584],[1687,584],[1687,634],[180,634]],"region":{"top_left_x":180,"top_left_y":584,"width":1507,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd23c3a665a7438d89738194689e80a1","type":"text","conversion_output":true,"text":"pregnant mother. The identification of such mothers is arranged through these physicians.","text_display":" pregnant mother. The identification of such mothers is arranged through these physicians.","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[183,677],[1944,677],[1944,728],[183,728]],"region":{"top_left_x":182,"top_left_y":676,"width":1763,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f686ad9cfaf4b92ab646cbb01f88622","type":"text","conversion_output":true,"text":"Experience gained in the Pilot-2 study of this project is utilized to optimize the efficacy of the","text_display":"\n\nExperience gained in the Pilot-2 study of this project is utilized to optimize the efficacy of the","confidence":1,"confidence_rate":1},{"cnt":[[180,726],[1944,726],[1944,776],[180,776]],"region":{"top_left_x":180,"top_left_y":726,"width":1765,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c367c29ab3764406bda052495d435631","type":"text","conversion_output":true,"text":"recruitment in the study proper (use of diabetes societies, information in mass media etc.). In that pilot","text_display":" recruitment in the study proper (use of diabetes societies, information in mass media etc.). In that pilot","confidence":1,"confidence_rate":1},{"cnt":[[183,773],[1944,773],[1944,823],[183,823]],"region":{"top_left_x":182,"top_left_y":773,"width":1763,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5a22c76138d4f5ab4e3cd11428b2707","type":"text","conversion_output":true,"text":"study we also found that weekly staff meetings and continuing recruitment during weekends and","text_display":" study we also found that weekly staff meetings and continuing recruitment during weekends and","confidence":1,"confidence_rate":1},{"cnt":[[180,821],[1944,821],[1944,872],[180,872]],"region":{"top_left_x":180,"top_left_y":820,"width":1765,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8691d67cfbe94c70b1664defcf47557c","type":"text","conversion_output":true,"text":"vacation periods substantially raises recruitment efficiency. Leaflets, distributed to \"candidate\" mothers,","text_display":" vacation periods substantially raises recruitment efficiency. Leaflets, distributed to \"candidate\" mothers,","confidence":1,"confidence_rate":1},{"cnt":[[180,868],[896,868],[896,922],[180,922]],"region":{"top_left_x":180,"top_left_y":867,"width":716,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"724e3fe40c8a499b8a147602d0680fda","type":"text","conversion_output":true,"text":"describing the project can be very helpful.","text_display":" describing the project can be very helpful.","confidence":1,"confidence_rate":1},{"cnt":[[748,1033],[1373,1033],[1373,1085],[748,1085]],"region":{"top_left_x":747,"top_left_y":1033,"width":626,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"572bba1669504f8889530eba815e9a66","type":"section_header","conversion_output":false,"children_ids":["23bcaf46aecc4577b238e81270300444"],"text":"","text_display":""},{"cnt":[[752,1040],[1366,1040],[1366,1081],[752,1081]],"region":{"top_left_x":751,"top_left_y":1039,"width":616,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23bcaf46aecc4577b238e81270300444","type":"text","conversion_output":true,"parent_id":"572bba1669504f8889530eba815e9a66","text":"D. SUBJECT ALLOCATION","text_display":"\n\n\\section*{D. SUBJECT ALLOCATION}","confidence":1,"confidence_rate":1},{"cnt":[[180,1130],[1944,1130],[1944,1182],[180,1182]],"region":{"top_left_x":180,"top_left_y":1130,"width":1765,"height":52},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"338072719bf04117ac859f9b24449676","type":"text","conversion_output":true,"text":"Randomization takes place before birth or immediately after the birth of the child. The research assistant","text_display":"\n\nRandomization takes place before birth or immediately after the birth of the child. The research assistant","confidence":1,"confidence_rate":1},{"cnt":[[180,1182],[1944,1182],[1944,1231],[180,1231]],"region":{"top_left_x":180,"top_left_y":1181,"width":1765,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc0fc4a926564c18a2f71f3d628dd937","type":"text","conversion_output":true,"text":"or investigator obtains the formula allocation code from the Data Management Unit (DMU) by","text_display":" or investigator obtains the formula allocation code from the Data Management Unit (DMU) by","confidence":1,"confidence_rate":1},{"cnt":[[183,1229],[1944,1229],[1944,1278],[183,1278]],"region":{"top_left_x":182,"top_left_y":1228,"width":1763,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0039b9479be41e0a98cd2b8de93abc2","type":"text","conversion_output":true,"text":"completing the Randomization Form electronically. Subjects who meet the inclusion and do not meet","text_display":" completing the Randomization Form electronically. Subjects who meet the inclusion and do not meet","confidence":1,"confidence_rate":1},{"cnt":[[183,1276],[1944,1276],[1944,1326],[183,1326]],"region":{"top_left_x":182,"top_left_y":1276,"width":1763,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcb23ada37014f349f4f309fcc0f64d6","type":"text","conversion_output":true,"text":"exclusion criteria are randomized as follows: randomization in each strata will be within four blocks.","text_display":" exclusion criteria are randomized as follows: randomization in each strata will be within four blocks.","confidence":1,"confidence_rate":1},{"cnt":[[183,1323],[1944,1323],[1944,1377],[183,1377]],"region":{"top_left_x":182,"top_left_y":1323,"width":1763,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eebfd19ac5ab4739bb91a110ede6b9b1","type":"text","conversion_output":true,"text":"Subjects will receive either the test formula, casein hydrolysate (Nutramigen \\({ }^{\\text {TM }}\\), Mead Johnson","text_display":" Subjects will receive either the test formula, casein hydrolysate (Nutramigen \\({ }^{\\text {TM }}\\), Mead Johnson","confidence":0.98828125,"confidence_rate":0.9998975012902904},{"cnt":[[180,1371],[1944,1371],[1944,1422],[180,1422]],"region":{"top_left_x":180,"top_left_y":1370,"width":1765,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ff6af56641b4689aa2ac9e2dcf4a5ce","type":"text","conversion_output":true,"text":"Nutritionals), not containing antigenic CM protein, or a CM protein containing control formula which","text_display":" Nutritionals), not containing antigenic CM protein, or a CM protein containing control formula which","confidence":1,"confidence_rate":1},{"cnt":[[180,1420],[1944,1420],[1944,1472],[180,1472]],"region":{"top_left_x":180,"top_left_y":1420,"width":1765,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"edfadb8669e24e9b8132c67a7f6e60fe","type":"text","conversion_output":true,"text":"has an addition (20\\%) of Nutramigen, whenever breast milk is not available. Any subject requiring","text_display":" has an addition (20\\%) of Nutramigen, whenever breast milk is not available. Any subject requiring","confidence":0.5727396011352539,"confidence_rate":0.9945509383888674},{"cnt":[[183,1470],[1944,1470],[1944,1519],[183,1519]],"region":{"top_left_x":182,"top_left_y":1469,"width":1763,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ab02504cedb47de85c7b916951d7438","type":"text","conversion_output":true,"text":"supplemental feeding prior to randomization (e.g. infants born at night or on weekends) is given banked","text_display":" supplemental feeding prior to randomization (e.g. infants born at night or on weekends) is given banked","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[180,1517],[1944,1517],[1944,1566],[180,1566]],"region":{"top_left_x":180,"top_left_y":1516,"width":1765,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8428a7d7151a4d2fbe109f31457b9f4d","type":"text","conversion_output":true,"text":"breast milk or Nutramigen. The randomization code will be kept by the manufacturer and it will be","text_display":" breast milk or Nutramigen. The randomization code will be kept by the manufacturer and it will be","confidence":1,"confidence_rate":1},{"cnt":[[183,1564],[881,1564],[881,1618],[183,1618]],"region":{"top_left_x":182,"top_left_y":1564,"width":699,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e22fae1a00f4fd7938fdb65bf172166","type":"text","conversion_output":true,"text":"opened when TRIGR study is completed.","text_display":" opened when TRIGR study is completed.","confidence":1,"confidence_rate":1},{"cnt":[[183,1659],[1944,1659],[1944,1712],[183,1712]],"region":{"top_left_x":182,"top_left_y":1658,"width":1763,"height":55},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"774cf45a489e44d4a855c48d3fcdbfdd","type":"text","conversion_output":true,"text":"Cord blood is obtained from newborn infants whenever possible or alternatively a heel prick is","text_display":"\n\nCord blood is obtained from newborn infants whenever possible or alternatively a heel prick is","confidence":1,"confidence_rate":1},{"cnt":[[183,1708],[1944,1708],[1944,1760],[183,1760]],"region":{"top_left_x":182,"top_left_y":1708,"width":1763,"height":52},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3a99e680b954b61a5c59dbd9e675ffa","type":"text","conversion_output":true,"text":"performed to obtain capillary blood as soon as possible after birth, at the latest at the age of 7 days. The","text_display":" performed to obtain capillary blood as soon as possible after birth, at the latest at the age of 7 days. The","confidence":1,"confidence_rate":1},{"cnt":[[183,1755],[1944,1755],[1944,1807],[183,1807]],"region":{"top_left_x":182,"top_left_y":1755,"width":1763,"height":52},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f782383c3bef4a82a1b5323476364da8","type":"text","conversion_output":true,"text":"blood sample is forwarded to the continental genotyping center and screening performed for the","text_display":" blood sample is forwarded to the continental genotyping center and screening performed for the","confidence":1,"confidence_rate":1},{"cnt":[[183,1805],[1944,1805],[1944,1854],[183,1854]],"region":{"top_left_x":182,"top_left_y":1804,"width":1763,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cbda3c520c14bfa90bc9d4aa7e9fc84","type":"text","conversion_output":true,"text":"presence of the genotypes listed below indicating an increased genetic risk. Results are entered into the","text_display":" presence of the genotypes listed below indicating an increased genetic risk. Results are entered into the","confidence":1,"confidence_rate":1},{"cnt":[[183,1852],[1944,1852],[1944,1901],[183,1901]],"region":{"top_left_x":182,"top_left_y":1851,"width":1763,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36d994cc2be54bd799ce23bc1c65c357","type":"text","conversion_output":true,"text":"Central Data Base immediately when available (within 2 weeks after the sampling) and are sent by e-","text_display":" Central Data Base immediately when available (within 2 weeks after the sampling) and are sent by e","confidence":1,"confidence_rate":1},{"cnt":[[180,1899],[1944,1899],[1944,1949],[180,1949]],"region":{"top_left_x":180,"top_left_y":1899,"width":1765,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"695b8544f4d242938065b20a37aaf0bb","type":"text","conversion_output":true,"text":"mail from DMU to the national coordinating centers and/or to the local study center in question and to","text_display":"mail from DMU to the national coordinating centers and/or to the local study center in question and to","confidence":1,"confidence_rate":1},{"cnt":[[180,1946],[1944,1946],[1944,2000],[180,2000]],"region":{"top_left_x":180,"top_left_y":1946,"width":1765,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8171663d869b456e8d05f50ccbdb5e12","type":"text","conversion_output":true,"text":"the Study Monitors. Only subjects with these genotypes are included in the nutritional prevention trial;","text_display":" the Study Monitors. Only subjects with these genotypes are included in the nutritional prevention trial;","confidence":1,"confidence_rate":1},{"cnt":[[183,1996],[1944,1996],[1944,2047],[183,2047]],"region":{"top_left_x":182,"top_left_y":1995,"width":1763,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9288b6c569b46f2bc4ca566fac930f4","type":"text","conversion_output":true,"text":"all other subjects are withdrawn from the study at that time; their parents are told that genetic screening","text_display":" all other subjects are withdrawn from the study at that time; their parents are told that genetic screening","confidence":1,"confidence_rate":1},{"cnt":[[183,2045],[1944,2045],[1944,2095],[183,2095]],"region":{"top_left_x":182,"top_left_y":2045,"width":1763,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cf7f5e3058c4b128b0c64ccd14cc43a","type":"text","conversion_output":true,"text":"suggests that their child does not fall into the increased genetic risk group for type 1 diabetes and they","text_display":" suggests that their child does not fall into the increased genetic risk group for type 1 diabetes and they","confidence":0.99755859375,"confidence_rate":0.9999785582005648},{"cnt":[[180,2093],[1944,2093],[1944,2142],[180,2142]],"region":{"top_left_x":180,"top_left_y":2092,"width":1765,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce792e6f5fdf49c1bb0399096e7378dd","type":"text","conversion_output":true,"text":"are appropriately thanked for their participation. It is emphasized that their child might still develop","text_display":" are appropriately thanked for their participation. It is emphasized that their child might still develop","confidence":1,"confidence_rate":1},{"cnt":[[183,2140],[1038,2140],[1038,2189],[183,2189]],"region":{"top_left_x":182,"top_left_y":2139,"width":856,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a17d73a83aac44bfbb116d8945a1f66a","type":"text","conversion_output":true,"text":"diabetes despite not meeting the eligibility criteria.","text_display":" diabetes despite not meeting the eligibility criteria.","confidence":1,"confidence_rate":1},{"cnt":[[1916,2582],[1955,2582],[1955,2628],[1916,2628]],"region":{"top_left_x":1916,"top_left_y":2582,"width":40,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfa0cb352d6f4617be7c8d21e7377958","type":"page_info","conversion_output":false,"text":"6","text_display":"","confidence":0.99951171875,"confidence_rate":0.99951171875}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-08","page":8,"lines":[{"cnt":[[804,125],[1317,125],[1317,174],[804,174]],"region":{"top_left_x":803,"top_left_y":124,"width":514,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef7b8bbe23984d869481a03077eeee9b","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[765,335],[1356,335],[1356,397],[765,397]],"region":{"top_left_x":764,"top_left_y":335,"width":592,"height":63},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e1dbcac00214cc888f1af8f756a42ab","type":"section_header","conversion_output":false,"children_ids":["194c55f074fa40ff897c19858a154625"],"text":"","text_display":""},{"cnt":[[773,344],[1349,344],[1349,389],[773,389]],"region":{"top_left_x":773,"top_left_y":343,"width":577,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"194c55f074fa40ff897c19858a154625","type":"text","conversion_output":true,"parent_id":"2e1dbcac00214cc888f1af8f756a42ab","text":"E. GENETIC SCREENING","text_display":"\n\n\\section*{E. GENETIC SCREENING}","confidence":0.99951171875,"confidence_rate":0.9999804641709025},{"cnt":[[180,438],[1944,438],[1944,488],[180,488]],"region":{"top_left_x":180,"top_left_y":438,"width":1765,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e5916b9257d442082b48d6f02306603","type":"text","conversion_output":true,"text":"The options for genetic screening vary between the extremes of a very high risk population requiring a","text_display":"\n\nThe options for genetic screening vary between the extremes of a very high risk population requiring a","confidence":1,"confidence_rate":1},{"cnt":[[180,486],[1944,486],[1944,535],[180,535]],"region":{"top_left_x":180,"top_left_y":485,"width":1765,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc746acfcfb04fda8ffd16f413334682","type":"text","conversion_output":true,"text":"small sample size (e.g. DQA1*0301-DQB1*0302/DQA1*0501-DQB1*02 heterozygotes), and a lower","text_display":" small sample size (e.g. DQA1*0301-DQB1*0302/DQA1*0501-DQB1*02 heterozygotes), and a lower","confidence":1,"confidence_rate":1},{"cnt":[[180,535],[1944,535],[1944,587],[180,587]],"region":{"top_left_x":180,"top_left_y":534,"width":1765,"height":53},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"198dd5ca0ac34277b084b4ee77429ead","type":"text","conversion_output":true,"text":"average risk population with larger sample size (e.g. newborn infants with a FDR but with no additional","text_display":" average risk population with larger sample size (e.g. newborn infants with a FDR but with no additional","confidence":1,"confidence_rate":1},{"cnt":[[180,580],[1944,580],[1944,634],[180,634]],"region":{"top_left_x":180,"top_left_y":580,"width":1765,"height":54},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f69bd7e2f694fd3bef520a7ca741f60","type":"text","conversion_output":true,"text":"genetic selection applied). Based on anticipated rates of identification of eligible newborn infants and a","text_display":" genetic selection applied). Based on anticipated rates of identification of eligible newborn infants and a","confidence":1,"confidence_rate":1},{"cnt":[[180,629],[1944,629],[1944,681],[180,681]],"region":{"top_left_x":180,"top_left_y":629,"width":1765,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eef90f527f0a49bea841a0325dd9f75f","type":"text","conversion_output":true,"text":"feasible enrollment period, we propose to base the selection on the presence of the following genotypes,","text_display":" feasible enrollment period, we propose to base the selection on the presence of the following genotypes,","confidence":1,"confidence_rate":1},{"cnt":[[180,679],[816,679],[816,728],[180,728]],"region":{"top_left_x":180,"top_left_y":678,"width":637,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33463c74dfee499aa71224bdc5f696e9","type":"text","conversion_output":true,"text":"representing different risk categories:","text_display":" representing different risk categories:","confidence":1,"confidence_rate":1},{"cnt":[[183,769],[765,769],[765,823],[183,823]],"region":{"top_left_x":182,"top_left_y":769,"width":583,"height":54},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"331fcc7135d04cefb7859143aa8c7c3f","type":"text","conversion_output":true,"text":"1. HLA-DQB1*0302/DQB1*02","text_display":"\n1. HLA-DQB1*0302/DQB1*02","confidence":0.9990234375,"confidence_rate":0.9999663095451973},{"cnt":[[180,821],[1420,821],[1420,872],[180,872]],"region":{"top_left_x":180,"top_left_y":820,"width":1241,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46892fdb1ad64b1b959fb2d681779972","type":"text","conversion_output":true,"text":"2. HLA-DQB1*0302/x (x not DQB1*02, DQB1*0301 or DQB1*0602)","text_display":"\n2. HLA-DQB1*0302/x (x not DQB1*02, DQB1*0301 or DQB1*0602)","confidence":0.9243049856740981,"confidence_rate":0.9987513644690543},{"cnt":[[180,868],[1757,868],[1757,922],[180,922]],"region":{"top_left_x":180,"top_left_y":867,"width":1578,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57c9194b92c14ec1aec40c48f5096d0d","type":"text","conversion_output":true,"text":"3. HLA-DQA1*05-DQB1*02/y (y not DQA1*0201-DQB1*02, DQB1*0301, DQB1*0302,","text_display":"\n3. HLA-DQA1*05-DQB1*02/y (y not DQA1*0201-DQB1*02, DQB1*0301, DQB1*0302,","confidence":0.9975600242614746,"confidence_rate":0.9999682737847114},{"cnt":[[254,917],[763,917],[763,967],[254,967]],"region":{"top_left_x":253,"top_left_y":917,"width":510,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9510fbd6b8ab4f448c675bfeb097390e","type":"text","conversion_output":true,"text":"DQB1*0602 or DQB1*0603)","text_display":" DQB1*0602 or DQB1*0603)","confidence":1,"confidence_rate":1},{"cnt":[[180,965],[1757,965],[1757,1016],[180,1016]],"region":{"top_left_x":180,"top_left_y":964,"width":1578,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ca01addc81034eccac1347cba462533c","type":"text","conversion_output":true,"text":"4. HLA-DQA1*03-DQB1*02/y (y not DQA1*0201-DQB1*02, DQB1*0301, DQB1*0302,","text_display":"\n4. HLA-DQA1*03-DQB1*02/y (y not DQA1*0201-DQB1*02, DQB1*0301, DQB1*0302,","confidence":1,"confidence_rate":1},{"cnt":[[254,1010],[763,1010],[763,1063],[254,1063]],"region":{"top_left_x":253,"top_left_y":1009,"width":510,"height":55},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0795fa17d60c455b8180143ea1c1f249","type":"text","conversion_output":true,"text":"DQB1*0602 or DQB1*0603)","text_display":" DQB1*0602 or DQB1*0603)","confidence":1,"confidence_rate":1},{"cnt":[[180,1109],[1944,1109],[1944,1158],[180,1158]],"region":{"top_left_x":180,"top_left_y":1108,"width":1765,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1f06da9ef584ed0a2233bc8c8ccd350","type":"text","conversion_output":true,"text":"The HLA-DQB1 genotyping used in pilot studies has been completed by additional DQA1 typing in","text_display":"\n\nThe HLA-DQB1 genotyping used in pilot studies has been completed by additional DQA1 typing in","confidence":0.99755859375,"confidence_rate":0.9999750575422747},{"cnt":[[180,1156],[1946,1156],[1946,1205],[180,1205]],"region":{"top_left_x":180,"top_left_y":1155,"width":1767,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf0708ccac854766932333aee2d98786","type":"text","conversion_output":true,"text":"samples positive for DQB1*02 allele but without protective DQB1 alleles. These samples are analyzed","text_display":" samples positive for DQB1*02 allele but without protective DQB1 alleles. These samples are analyzed","confidence":1,"confidence_rate":1},{"cnt":[[180,1203],[1946,1203],[1946,1257],[180,1257]],"region":{"top_left_x":180,"top_left_y":1203,"width":1767,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62c5fa6c7d5c45aebab1299327a6d732","type":"text","conversion_output":true,"text":"for the presence of DQA1 alleles DQA1*0201, DQA1*03 and DQA1*05. This procedure allows the","text_display":" for the presence of DQA1 alleles DQA1*0201, DQA1*03 and DQA1*05. This procedure allows the","confidence":0.99169921875,"confidence_rate":0.9999122625377982},{"cnt":[[180,1250],[1944,1250],[1944,1302],[180,1302]],"region":{"top_left_x":180,"top_left_y":1250,"width":1765,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34a669ae8ad345d4a47a30edb91e86e0","type":"text","conversion_output":true,"text":"distinction between the diabetes risk associated (DQA1*05-DQB1*02 and DQA1*03-DQB1*02) and","text_display":" distinction between the diabetes risk associated (DQA1*05-DQB1*02 and DQA1*03-DQB1*02) and","confidence":1,"confidence_rate":1},{"cnt":[[180,1298],[1946,1298],[1946,1351],[180,1351]],"region":{"top_left_x":180,"top_left_y":1297,"width":1767,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3710eaa971440ab91d59b283e3e7319","type":"text","conversion_output":true,"text":"non-associated haplotypes (DQA1*0201-DQB1*02). The effect of this further step is relatively small in","text_display":" non-associated haplotypes (DQA1*0201-DQB1*02). The effect of this further step is relatively small in","confidence":0.99853515625,"confidence_rate":0.9999861706835268},{"cnt":[[180,1349],[1944,1349],[1944,1399],[180,1399]],"region":{"top_left_x":180,"top_left_y":1349,"width":1765,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"283feed5de044d8db3b4577fa77df690","type":"text","conversion_output":true,"text":"the populations of Northern European descent, but more important in some Mediterranean and Black","text_display":" the populations of Northern European descent, but more important in some Mediterranean and Black","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[180,1396],[397,1396],[397,1450],[180,1450]],"region":{"top_left_x":180,"top_left_y":1396,"width":218,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb0c9a3348b343e78e798ea7adcb8e9c","type":"text","conversion_output":true,"text":"populations.","text_display":" populations.","confidence":1,"confidence_rate":1},{"cnt":[[180,1491],[1949,1491],[1949,1543],[180,1543]],"region":{"top_left_x":180,"top_left_y":1491,"width":1769,"height":52},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1894b95009ad4db6912a9fc57f3c6317","type":"text","conversion_output":true,"text":"The efficiency of this new screening procedure was tested in an enlarged series of 289 familial cases of","text_display":"\n\nThe efficiency of this new screening procedure was tested in an enlarged series of 289 familial cases of","confidence":1,"confidence_rate":1},{"cnt":[[180,1538],[1949,1538],[1949,1592],[180,1592]],"region":{"top_left_x":180,"top_left_y":1538,"width":1769,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3710de3b605d40eeb2d3c949c155a152","type":"text","conversion_output":true,"text":"type 1 diabetes in Finland as well as in the newborn infants recruited for the Pilot-2 study. 85.8\\% of","text_display":" type 1 diabetes in Finland as well as in the newborn infants recruited for the Pilot-2 study. 85.8\\% of","confidence":0.99658203125,"confidence_rate":0.9999688748175845},{"cnt":[[180,1588],[1949,1588],[1949,1639],[180,1639]],"region":{"top_left_x":180,"top_left_y":1587,"width":1769,"height":53},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"194a89efa0af475d85e501b0be13be0a","type":"text","conversion_output":true,"text":"familial cases were positive for the selected genotypes which on the other hand were present in \\(50 \\%\\) of","text_display":" familial cases were positive for the selected genotypes which on the other hand were present in \\(50 \\%\\) of","confidence":0.99755859375,"confidence_rate":0.9999777785074303},{"cnt":[[180,1637],[1946,1637],[1946,1687],[180,1687]],"region":{"top_left_x":180,"top_left_y":1637,"width":1767,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15b24f2903ba414a85a898017c785dc7","type":"text","conversion_output":true,"text":"the 471 newborn infants with a FDR affected by type 1 diabetes. If an approximate figure of \\(10 \\%\\) is","text_display":" the 471 newborn infants with a FDR affected by type 1 diabetes. If an approximate figure of \\(10 \\%\\) is","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[180,1680],[1944,1680],[1944,1734],[180,1734]],"region":{"top_left_x":180,"top_left_y":1680,"width":1765,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04526828c1374c0b9442909fb053529b","type":"text","conversion_output":true,"text":"used for the risk of a FDR to develop multiple autoantibodies before the age of 6 yrs , positive predictive","text_display":" used for the risk of a FDR to develop multiple autoantibodies before the age of 6 yrs , positive predictive","confidence":0.9980475902557373,"confidence_rate":0.9999832965653107},{"cnt":[[180,1732],[1944,1732],[1944,1781],[180,1781]],"region":{"top_left_x":180,"top_left_y":1731,"width":1765,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e0fe5d0f5ba47e9a0570a668dea96eb","type":"text","conversion_output":true,"text":"values delineate a risk of \\(17.1 \\%\\) for those with risk genotypes compared to a risk of \\(2.8 \\%\\) of those","text_display":" values delineate a risk of \\(17.1 \\%\\) for those with risk genotypes compared to a risk of \\(2.8 \\%\\) of those","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[180,1779],[1944,1779],[1944,1830],[180,1830]],"region":{"top_left_x":180,"top_left_y":1778,"width":1765,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b33ec5cd12c74ff9966543ab10d102c5","type":"text","conversion_output":true,"text":"without a risk genotype. This figure is close to the \\(20.7 \\%\\) proportion given in Table 1 for the positivity","text_display":" without a risk genotype. This figure is close to the \\(20.7 \\%\\) proportion given in Table 1 for the positivity","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[180,1826],[1051,1826],[1051,1880],[180,1880]],"region":{"top_left_x":180,"top_left_y":1826,"width":871,"height":54},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb596cabc1ab4408a6a763ebe72147ce","type":"text","conversion_output":true,"text":"of at least two autoantibodies by the age of 6 years.","text_display":" of at least two autoantibodies by the age of 6 years.","confidence":1,"confidence_rate":1},{"cnt":[[180,1916],[1944,1916],[1944,1970],[180,1970]],"region":{"top_left_x":180,"top_left_y":1916,"width":1765,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51044beccaac4ae1ac71474ac4eac721","type":"text","conversion_output":true,"text":"The selected risk genotypes are present in \\(81.0 \\%\\) of Finnish children with type 1 diabetes and in \\(22.5 \\%\\)","text_display":"\n\nThe selected risk genotypes are present in \\(81.0 \\%\\) of Finnish children with type 1 diabetes and in \\(22.5 \\%\\)","confidence":0.9975595474243164,"confidence_rate":0.9999781838510657},{"cnt":[[180,1966],[1944,1966],[1944,2017],[180,2017]],"region":{"top_left_x":180,"top_left_y":1965,"width":1765,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f040b112ee4e46d398fb934f54ba1c73","type":"text","conversion_output":true,"text":"of the background population, the higher frequency in familial cases confirms our earlier observations","text_display":" of the background population, the higher frequency in familial cases confirms our earlier observations","confidence":1,"confidence_rate":1},{"cnt":[[180,2013],[1944,2013],[1944,2065],[180,2065]],"region":{"top_left_x":180,"top_left_y":2013,"width":1765,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0186bb34799f45ba920e92c7c2190650","type":"text","conversion_output":true,"text":"(4). We do not have available data on familial cases and newborn infants with a FDR with type 1","text_display":" (4). We do not have available data on familial cases and newborn infants with a FDR with type 1","confidence":1,"confidence_rate":1},{"cnt":[[180,2062],[1944,2062],[1944,2112],[180,2112]],"region":{"top_left_x":180,"top_left_y":2062,"width":1765,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"748f4ff995424c3fadb971d746381e62","type":"text","conversion_output":true,"text":"diabetes in other populations, but comparative analyses of genotype frequencies in patients with type 1","text_display":" diabetes in other populations, but comparative analyses of genotype frequencies in patients with type 1","confidence":1,"confidence_rate":1},{"cnt":[[180,2110],[1944,2110],[1944,2159],[180,2159]],"region":{"top_left_x":180,"top_left_y":2109,"width":1765,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d2d529c7fc54d80aca173df7bba44c7","type":"text","conversion_output":true,"text":"diabetes and healthy controls indicate that the genotyping protocol would function with quite similar","text_display":" diabetes and healthy controls indicate that the genotyping protocol would function with quite similar","confidence":1,"confidence_rate":1},{"cnt":[[180,2157],[1944,2157],[1944,2211],[180,2211]],"region":{"top_left_x":180,"top_left_y":2157,"width":1765,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"108accaea3144f898ac2ec2463fb303c","type":"text","conversion_output":true,"text":"efficiency in various populations to enrich high risk subjects for the study (Table 2). Several published","text_display":" efficiency in various populations to enrich high risk subjects for the study (Table 2). Several published","confidence":1,"confidence_rate":1},{"cnt":[[180,2204],[1944,2204],[1944,2258],[180,2258]],"region":{"top_left_x":180,"top_left_y":2204,"width":1765,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dbb56d88990423fb6a200328e9a3ad9","type":"text","conversion_output":true,"text":"data also support this view, although exact proportions cannot be deduced because of the lack of detailed","text_display":" data also support this view, although exact proportions cannot be deduced because of the lack of detailed","confidence":1,"confidence_rate":1},{"cnt":[[180,2254],[651,2254],[651,2305],[180,2305]],"region":{"top_left_x":180,"top_left_y":2253,"width":471,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"299f856be2a34e7abbb7cc9b859056b3","type":"text","conversion_output":true,"text":"genotype frequencies (5-7).","text_display":" genotype frequencies (5-7).","confidence":1,"confidence_rate":1},{"cnt":[[1912,2582],[1955,2582],[1955,2628],[1912,2628]],"region":{"top_left_x":1912,"top_left_y":2582,"width":44,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"663e9a7e9a9041c19634e207daf8d907","type":"page_info","conversion_output":false,"text":"7","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-09","page":9,"lines":[{"cnt":[[808,125],[1315,125],[1315,174],[808,174]],"region":{"top_left_x":807,"top_left_y":124,"width":508,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4dd722a2d1c24ca6a03244e6933224ed","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,247],[1721,247],[1721,296],[180,296]],"region":{"top_left_x":180,"top_left_y":247,"width":1541,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84f37e8bb4af4034a5b0066146933df7","type":"figure_label","conversion_output":false,"text":"Table 2. The HLA risk genotypes in patients and healthy controls from various populations","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,337],[2004,337],[2004,1001],[180,1001]],"region":{"top_left_x":180,"top_left_y":337,"width":1825,"height":665},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"019eaa944f564c908c580be1ba607dff","type":"table","conversion_output":true,"children_ids":["d6d0614508a647ae93f1bfd4f717780d","63fc65e01b7145a89c0b6f0f10f7d06c","9b13a96fc44244689fc44f407b34b0b2","3a908899c4c84a95b3e4cfaab74bd39e","71840f272170403cad6d83fba37793fb","726346b20e7e425a92e5fba02fb4b31b","85da8546ae894e73b7ab8f248dd26f7c","15ad0232af45442abbf69c7f39eddd28","1012e6ef313946be80e22e89e995f3b3","7cfedaf06b5147029d06012cc34b0850","fb43d766c97d401c9c7b4b61fbbbe4de","8f56d8c6f46a4d2a8c1c1a46b66ec135","fc3b51ade7114cc9a6a0d41f4ae62487","4b1c8df64be245d8b696412f41545888","cf1b3b11d4e24d33a66a4131d7a52e40","7b3e334b66924470a80f0670cd66dc4f","5ccfe0e35f7a4219adc3471b113fcb0b","cefb6fdb0d9941dea5e51fdc5c50f917","44d1e617eb7d4b9ba263c7cb6639e969","524ce0db8c31408b9c6bfede6ddae0d5","f21f252367c54a0795bb0b0928e9b015","9b4a08bc13884fa1baa2ff49c76a94f7","3ea5308245c04274903abb328cd67a39","41d442b66da64f2495547ad61901f89b","1422fbabc331429582993e1cd6282fb5","4aecfaf699f24eda9d5d1966689f245c","63bebdeae4434ae38c00d7af6baf4545","f98e02879d0c4009b12b08c63ce596d0","877f64d682a94dc6b654c4c6653f0a58","c00a1cb489e84c06a82c845d39f50ec9","d2a584bc9fc342c68e964d65acc42bf6","a7b5c19722f447bbb1c928d8aafd5ae5","9071c24dcd7241088418757593123327","8078f91a21114df0b9f4258ab3ec97ff","014da0b6bc4a4107bd606e48e9e7e1e8","edc37339efc64fe8a231a41dae372812","74e98343fafb4d8191914aab5ff2efe6","7e17089cb71546ef91fbf75ddb636ca1","fa87113cede14c148b37f319e29a0d68","45ecd0cfa77f48eaadfda6ac4805526a","c50e0fc9db9745b790819367b363ccc8","4e93b91acb7c4bc4acfaaf9d1812c050","8848ec0135254f11b75be93152f968b7","4f543e99784c47c0ac001f159ceddb58","1c1b3fa60cb742359b24d164b5215af4","dbeb710bad0841baaf2d4df2a4c7788d","8af003d3b9ca4eccb83c63a04419dcf5","f87ecb5cf3da44a8a9bfd803c8b7bfc1","1513f123fa1047c597ed47cc43f7f3bf","25bd8e7326d449368b2aaa7ed98e903b","9b2e66120a01419188a5e5bb6a5f9e67","f5049cc8c51c4d01accdb81aa5db600e","9f0964e0365d432f98a23b156d4bf777","fd115962c8f347d58ed9a5f39064dd09","eff71600ce754483a11fee4516f179c4","fb060f028b2641309d4ce9a7e988f3be","2ae8de7b4ba84bea919bc2a8652ac074","63ffb03bc0204766a201ee9fe67c19a6"],"selected_labels":["84f37e8bb4af4034a5b0066146933df7"],"text":"\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline \\multirow{2}{*}{Population} & \\multicolumn{2}{|c|}{Type 1 Diabetes} & \\multicolumn{2}{|c|}{Healthy Controls} & \\multirow{2}{*}{Reference} \\\\\n\\hline & \\% & N studied & \\% & N studied & \\\\\n\\hline Estonia & 78.4 & 97 & 14.1 & 269 & Nejentsev et al.:Tissue Antigens 1998:52:473 \\\\\n\\hline Finland & 81.0 & 316 & 22.5 & 1000 & Ilonen et al.: Eur. J. Immunogenet. 2000 27:225 \\\\\n\\hline Hungary & 87.5 & 112 & 21.0 & 210 & Hermann et al., personal communication \\\\\n\\hline Italy (Sardinia) & 90.0 & 100 & 40.0 & 100 & Songini \\& Ilonen, personal communication \\\\\n\\hline The Netherlands & 77.6 & 205 & 26.9 & 840 & Schipper et al., personal communication \\\\\n\\hline USA (Puerto Rico) & 78.9 & 114 & 26.9 & 108 & Santiago, Trucco \\& Frazer, personal communication \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 2. The HLA risk genotypes in patients and healthy controls from various populations}\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline \\multirow{2}{*}{Population} & \\multicolumn{2}{|c|}{Type 1 Diabetes} & \\multicolumn{2}{|c|}{Healthy Controls} & \\multirow{2}{*}{Reference} \\\\\n\\hline & \\% & N studied & \\% & N studied & \\\\\n\\hline Estonia & 78.4 & 97 & 14.1 & 269 & Nejentsev et al.:Tissue Antigens 1998:52:473 \\\\\n\\hline Finland & 81.0 & 316 & 22.5 & 1000 & Ilonen et al.: Eur. J. 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Each center maintains a reserve","confidence":1,"confidence_rate":1},{"cnt":[[180,1951],[1944,1951],[1944,2002],[180,2002]],"region":{"top_left_x":180,"top_left_y":1950,"width":1765,"height":53},"line":93,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0d36266bc1024f4fb6e66bc1490adb28","type":"text","conversion_output":true,"text":"supply of each \"color\" formula and is responsible for ensuring that the home supplies of each participant","text_display":" supply of each \"color\" formula and is responsible for ensuring that the home supplies of each participant","confidence":1,"confidence_rate":1},{"cnt":[[180,1998],[1944,1998],[1944,2052],[180,2052]],"region":{"top_left_x":180,"top_left_y":1998,"width":1765,"height":54},"line":94,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"055903c9b629492bbc042ce7f2daee2c","type":"text","conversion_output":true,"text":"are maintained. The company provides the coded formulas free of charge, whereas the shipping costs","text_display":" are maintained. The company provides the coded formulas free of charge, whereas the shipping costs","confidence":1,"confidence_rate":1},{"cnt":[[180,2050],[645,2050],[645,2099],[180,2099]],"region":{"top_left_x":180,"top_left_y":2049,"width":465,"height":51},"line":95,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ecf235f7d264b339f5adc9edf38904e","type":"text","conversion_output":true,"text":"are paid by the study grant.","text_display":" are paid by the study grant.","confidence":1,"confidence_rate":1},{"cnt":[[569,2179],[1553,2179],[1553,2228],[569,2228]],"region":{"top_left_x":569,"top_left_y":2178,"width":985,"height":50},"line":96,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8823441bc59478a8dfb87f836fe5b12","type":"section_header","conversion_output":false,"children_ids":["024bf3ca509543c49c3cfa5df7181c71"],"text":"","text_display":""},{"cnt":[[571,2183],[1549,2183],[1549,2224],[571,2224]],"region":{"top_left_x":571,"top_left_y":2182,"width":979,"height":42},"line":97,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"024bf3ca509543c49c3cfa5df7181c71","type":"text","conversion_output":true,"parent_id":"c8823441bc59478a8dfb87f836fe5b12","text":"G. IMPLEMENTATION OF INTERVENTION","text_display":"\n\n\\section*{G. IMPLEMENTATION OF INTERVENTION}","confidence":1,"confidence_rate":1},{"cnt":[[183,2277],[1944,2277],[1944,2327],[183,2327]],"region":{"top_left_x":182,"top_left_y":2277,"width":1763,"height":50},"line":98,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"015e7059b8d44edb94fadad079dc1ed5","type":"text","conversion_output":true,"text":"All recruited mothers are encouraged to breast-feed; the newborn infants are randomized before birth or","text_display":"\n\nAll recruited mothers are encouraged to breast-feed; the newborn infants are randomized before birth or","confidence":1,"confidence_rate":1},{"cnt":[[183,2325],[1944,2325],[1944,2376],[183,2376]],"region":{"top_left_x":182,"top_left_y":2324,"width":1763,"height":53},"line":99,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d5d35871830426198c985724841a527","type":"text","conversion_output":true,"text":"as soon as possible after birth so that any elective formula supplementation or weaning by the mother","text_display":" as soon as possible after birth so that any elective formula supplementation or weaning by the mother","confidence":1,"confidence_rate":1},{"cnt":[[183,2374],[1944,2374],[1944,2426],[183,2426]],"region":{"top_left_x":182,"top_left_y":2374,"width":1763,"height":52},"line":100,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75cde830e0ed424381a969322de15682","type":"text","conversion_output":true,"text":"will be done with the appropriate study formula. The duration of the intervention will be until at least 6","text_display":" will be done with the appropriate study formula. The duration of the intervention will be until at least 6","confidence":1,"confidence_rate":1},{"cnt":[[180,2423],[1944,2423],[1944,2473],[180,2473]],"region":{"top_left_x":180,"top_left_y":2423,"width":1765,"height":50},"line":101,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b77d768995bf4c0084794f209dc8ae88","type":"text","conversion_output":true,"text":"months of age. If the mother chooses to exclusively breastfeed up to the age of 6 months she is advised,","text_display":" months of age. If the mother chooses to exclusively breastfeed up to the age of 6 months she is advised,","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[1916,2587],[1942,2587],[1942,2628],[1916,2628]],"region":{"top_left_x":1916,"top_left_y":2586,"width":27,"height":42},"line":102,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b97602d7731048c8b2af0074c35be5b9","type":"page_info","conversion_output":false,"text":"8","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-10","page":10,"lines":[{"cnt":[[808,125],[1317,125],[1317,174],[808,174]],"region":{"top_left_x":807,"top_left_y":124,"width":510,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02bd8120d45544b0bbbc66fe00e61f8f","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,296],[180,296]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"566e066460e74920bd2de168ca4907bb","type":"text","conversion_output":true,"text":"thereafter, if milk supplementation is needed, to give the study formula until the age of 8 months.","text_display":"\nthereafter, if milk supplementation is needed, to give the study formula until the age of 8 months.","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1946,294],[1946,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1767,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"580cc79e89574f568905cfcb58992b74","type":"text","conversion_output":true,"text":"Similarly, if exclusive BF lasts for 5 months, the infant would receive study formula for 2 months until","text_display":" Similarly, if exclusive BF lasts for 5 months, the infant would receive study formula for 2 months until","confidence":0.51123046875,"confidence_rate":0.9941827705482362},{"cnt":[[180,339],[1944,339],[1944,397],[180,397]],"region":{"top_left_x":180,"top_left_y":339,"width":1765,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96a1b0f9f62e4e2fbc69447bd6cd10f2","type":"text","conversion_output":true,"text":"the age of 7 months. Infant feeding practices are altered as little as possible by the trial. In particular,","text_display":" the age of 7 months. Infant feeding practices are altered as little as possible by the trial. In particular,","confidence":1,"confidence_rate":1},{"cnt":[[180,391],[1302,391],[1302,443],[180,443]],"region":{"top_left_x":180,"top_left_y":391,"width":1122,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc982074c7a34776b50731ea6b7cc992","type":"text","conversion_output":true,"text":"BF practice(s) is entirely at the discretion of participating mothers.","text_display":" BF practice(s) is entirely at the discretion of participating mothers.","confidence":0.99658203125,"confidence_rate":0.9999555357502582},{"cnt":[[180,486],[1944,486],[1944,539],[180,539]],"region":{"top_left_x":180,"top_left_y":485,"width":1765,"height":55},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8a9ebbb2553432992e0f4b28507c484","type":"text","conversion_output":true,"text":"The rationale for the 6-8 month intervention period is based on the following considerations: in early","text_display":"\n\nThe rationale for the 6-8 month intervention period is based on the following considerations: in early","confidence":0.990234375,"confidence_rate":0.9999082881174898},{"cnt":[[180,533],[1944,533],[1944,587],[180,587]],"region":{"top_left_x":180,"top_left_y":532,"width":1765,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93c1c3dac8854eafbcaee3bf2e027b15","type":"text","conversion_output":true,"text":"infancy the child receives the major part of energy in liquid form, either as human milk or CM-based","text_display":" infancy the child receives the major part of energy in liquid form, either as human milk or CM-based","confidence":1,"confidence_rate":1},{"cnt":[[180,580],[1944,580],[1944,634],[180,634]],"region":{"top_left_x":180,"top_left_y":580,"width":1765,"height":54},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4745783a4fa415b8ab1cfe0eabf4b09","type":"text","conversion_output":true,"text":"formula. The period chosen provides a reasonable and practical safety margin over the \\(2-3\\) months","text_display":" formula. The period chosen provides a reasonable and practical safety margin over the \\(2-3\\) months","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[180,627],[1944,627],[1944,681],[180,681]],"region":{"top_left_x":180,"top_left_y":627,"width":1765,"height":55},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f793a854f4e4f5f9cb5162b1ef8075b","type":"text","conversion_output":true,"text":"\"vulnerable\" time when the gut is permeable to proteins, as suggested in several epidemiological studies","text_display":" \"vulnerable\" time when the gut is permeable to proteins, as suggested in several epidemiological studies","confidence":1,"confidence_rate":1},{"cnt":[[180,675],[544,675],[544,728],[180,728]],"region":{"top_left_x":180,"top_left_y":674,"width":364,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e17f6c79ef0147738b5493681fec6037","type":"text","conversion_output":true,"text":"(reviewed in ref. 10).","text_display":" (reviewed in ref. 10).","confidence":1,"confidence_rate":1},{"cnt":[[176,767],[556,767],[556,831],[176,831]],"region":{"top_left_x":176,"top_left_y":766,"width":381,"height":66},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"112a74594fa548af8f2018a10fd76f6f","type":"section_header","conversion_output":false,"children_ids":["6c62d5c9082f4c53abd61160243f94fa"],"text":"","text_display":""},{"cnt":[[183,773],[552,773],[552,827],[183,827]],"region":{"top_left_x":182,"top_left_y":773,"width":371,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c62d5c9082f4c53abd61160243f94fa","type":"text","conversion_output":true,"parent_id":"112a74594fa548af8f2018a10fd76f6f","text":"Dietary information","text_display":"\n\n\\section*{Dietary information}","confidence":1,"confidence_rate":1},{"cnt":[[180,834],[1946,834],[1946,887],[180,887]],"region":{"top_left_x":180,"top_left_y":833,"width":1767,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfd5927977fa45fc8736e28577f9c69a","type":"text","conversion_output":true,"text":"Dietary advice is given by a member of the study team at the first contact with the family after","text_display":"\n\nDietary advice is given by a member of the study team at the first contact with the family after","confidence":1,"confidence_rate":1},{"cnt":[[180,881],[1946,881],[1946,935],[180,935]],"region":{"top_left_x":180,"top_left_y":880,"width":1767,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f015064f4572491ca6d8c6c499271614","type":"text","conversion_output":true,"text":"randomization, at the 2 week, \\(1,2,4\\) and 5 month telephone calls from the center to the mother, and at 7","text_display":" randomization, at the 2 week, \\(1,2,4\\) and 5 month telephone calls from the center to the mother, and at 7","confidence":0.9912149906158447,"confidence_rate":0.9999239354354943},{"cnt":[[180,930],[1944,930],[1944,984],[180,984]],"region":{"top_left_x":180,"top_left_y":930,"width":1765,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35693970da704613b218f790cb2c787d","type":"text","conversion_output":true,"text":"and 8 months for those infants who continue in the intervention beyond the age of 6 months, and at the 3","text_display":" and 8 months for those infants who continue in the intervention beyond the age of 6 months, and at the 3","confidence":1,"confidence_rate":1},{"cnt":[[180,975],[1949,975],[1949,1033],[180,1033]],"region":{"top_left_x":180,"top_left_y":975,"width":1769,"height":59},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"619b5a158fbe49e3838228cd8247cf19","type":"text","conversion_output":true,"text":"and 6 month visits. The families receive both written and oral instructions about infant feeding during","text_display":" and 6 month visits. The families receive both written and oral instructions about infant feeding during","confidence":1,"confidence_rate":1},{"cnt":[[180,1025],[1949,1025],[1949,1079],[180,1079]],"region":{"top_left_x":180,"top_left_y":1024,"width":1769,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97a1e60456e94091b72816a639cb7495","type":"text","conversion_output":true,"text":"the intervention period. Parents will be given a pamphlet which describes the sequence and amounts of","text_display":" the intervention period. Parents will be given a pamphlet which describes the sequence and amounts of","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[180,1074],[1944,1074],[1944,1128],[180,1128]],"region":{"top_left_x":180,"top_left_y":1074,"width":1765,"height":54},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a35a6f14eafb417ab5a5fbb9ca78d92c","type":"text","conversion_output":true,"text":"food recommended at specific ages, according to local guidelines. It is important to avoid any conta-","text_display":" food recommended at specific ages, according to local guidelines. It is important to avoid any conta","confidence":1,"confidence_rate":1},{"cnt":[[180,1121],[1944,1121],[1944,1175],[180,1175]],"region":{"top_left_x":180,"top_left_y":1121,"width":1765,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59a2e57525fa43468ddee5851395edf8","type":"text","conversion_output":true,"text":"mination of the dietary intervention with sources of CM protein (including milk products, beef, and","text_display":"mination of the dietary intervention with sources of CM protein (including milk products, beef, and","confidence":1,"confidence_rate":1},{"cnt":[[180,1169],[1944,1169],[1944,1222],[180,1222]],"region":{"top_left_x":180,"top_left_y":1168,"width":1765,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29378dea3d7c4fd79ad642d2a15342fb","type":"text","conversion_output":true,"text":"veal) contained in foods ingested by the infant. Thus, parents are provided with a list of all solid foods","text_display":" veal) contained in foods ingested by the infant. Thus, parents are provided with a list of all solid foods","confidence":1,"confidence_rate":1},{"cnt":[[180,1216],[1944,1216],[1944,1274],[180,1274]],"region":{"top_left_x":180,"top_left_y":1216,"width":1765,"height":59},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91b7ed638ef140fe9264ec12d31e6d42","type":"text","conversion_output":true,"text":"giving choices of brand names which can be given to the infant and which do not contain CM protein;","text_display":" giving choices of brand names which can be given to the infant and which do not contain CM protein;","confidence":1,"confidence_rate":1},{"cnt":[[180,1263],[1944,1263],[1944,1319],[180,1319]],"region":{"top_left_x":180,"top_left_y":1263,"width":1765,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bffb9ee7950433ab4af9c735ac0b646","type":"text","conversion_output":true,"text":"they are also provided with a list of foods to be avoided, as they contain CM protein. Dietary advice","text_display":" they are also provided with a list of foods to be avoided, as they contain CM protein. Dietary advice","confidence":1,"confidence_rate":1},{"cnt":[[180,1313],[1944,1313],[1944,1369],[180,1369]],"region":{"top_left_x":180,"top_left_y":1312,"width":1765,"height":57},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40f747b06c184982a370e6d1782e4475","type":"text","conversion_output":true,"text":"leaflets, dietary forms and questionnaires are translated into relevant languages and adapted to national","text_display":" leaflets, dietary forms and questionnaires are translated into relevant languages and adapted to national","confidence":1,"confidence_rate":1},{"cnt":[[180,1362],[1944,1362],[1944,1416],[180,1416]],"region":{"top_left_x":180,"top_left_y":1362,"width":1765,"height":54},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b87f0305f6e4e9b843cd2f9ccb444c8","type":"text","conversion_output":true,"text":"practices. The TRIGR Manual of Operations contains detailed instructions about the dietary interviews","text_display":" practices. The TRIGR Manual of Operations contains detailed instructions about the dietary interviews","confidence":1,"confidence_rate":1},{"cnt":[[180,1409],[1944,1409],[1944,1463],[180,1463]],"region":{"top_left_x":180,"top_left_y":1409,"width":1765,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"464667addbea4fa2bf5ddd8635147590","type":"text","conversion_output":true,"text":"and forms. Post-intervention diets follow generally accepted practices. Designated personnel will be","text_display":" and forms. Post-intervention diets follow generally accepted practices. Designated personnel will be","confidence":1,"confidence_rate":1},{"cnt":[[180,1457],[1944,1457],[1944,1515],[180,1515]],"region":{"top_left_x":180,"top_left_y":1456,"width":1765,"height":59},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2e34a5c596244cfa881f127ff20773d","type":"text","conversion_output":true,"text":"available during working hours to deal with urgent nutritional questions by telephone (e.g. feeding","text_display":" available during working hours to deal with urgent nutritional questions by telephone (e.g. feeding","confidence":1,"confidence_rate":1},{"cnt":[[180,1504],[402,1504],[402,1558],[180,1558]],"region":{"top_left_x":180,"top_left_y":1503,"width":222,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ff8ce1e013d4af7bce1634cd39f3fc9","type":"text","conversion_output":true,"text":"intolerance).","text_display":" intolerance).","confidence":1,"confidence_rate":1},{"cnt":[[174,1594],[1068,1594],[1068,1663],[174,1663]],"region":{"top_left_x":174,"top_left_y":1594,"width":894,"height":69},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93584f06472644538c52e186d5e75b8c","type":"section_header","conversion_output":false,"children_ids":["00196dde4cb34de28c481bae5efd59c2"],"text":"","text_display":""},{"cnt":[[180,1603],[1059,1603],[1059,1656],[180,1656]],"region":{"top_left_x":180,"top_left_y":1602,"width":880,"height":55},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00196dde4cb34de28c481bae5efd59c2","type":"text","conversion_output":true,"parent_id":"93584f06472644538c52e186d5e75b8c","text":"Monitoring of compliance and retention strategy","text_display":"\n\n\\section*{Monitoring of compliance and retention strategy}","confidence":1,"confidence_rate":1},{"cnt":[[180,1661],[1944,1661],[1944,1717],[180,1717]],"region":{"top_left_x":180,"top_left_y":1660,"width":1765,"height":57},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6197272b082a41e19343d39afdb763c7","type":"text","conversion_output":true,"text":"The diet of the infant and the compliance with the avoidance of CM proteins are assessed at the delivery","text_display":"\n\nThe diet of the infant and the compliance with the avoidance of CM proteins are assessed at the delivery","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[180,1710],[1944,1710],[1944,1764],[180,1764]],"region":{"top_left_x":180,"top_left_y":1710,"width":1765,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"813110139f254b1e81dbc094386e70e5","type":"text","conversion_output":true,"text":"hospital by interview, by a telephone interview when the infant 2 week-old, \\(1,2,4\\), and 5 month-old,","text_display":" hospital by interview, by a telephone interview when the infant 2 week-old, \\(1,2,4\\), and 5 month-old,","confidence":0.965489387512207,"confidence_rate":0.9996919757923978},{"cnt":[[183,1757],[1944,1757],[1944,1811],[183,1811]],"region":{"top_left_x":182,"top_left_y":1757,"width":1763,"height":55},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75acbb0d123a4307a8d8a39327eec574","type":"text","conversion_output":true,"text":"and by an interview during the visits at the age of 3,6 and 9 months. Those families, whose infants","text_display":" and by an interview during the visits at the age of 3,6 and 9 months. Those families, whose infants","confidence":0.962890625,"confidence_rate":0.9996562822572389},{"cnt":[[180,1805],[1944,1805],[1944,1858],[180,1858]],"region":{"top_left_x":180,"top_left_y":1804,"width":1765,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3a25ed0fccb49f89d53e7924047b88f","type":"text","conversion_output":true,"text":"continue in the intervention beyond the age of 6 months, are in addition interviewed by phone, when the","text_display":" continue in the intervention beyond the age of 6 months, are in addition interviewed by phone, when the","confidence":1,"confidence_rate":1},{"cnt":[[180,1852],[1946,1852],[1946,1910],[180,1910]],"region":{"top_left_x":180,"top_left_y":1851,"width":1767,"height":59},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5cd72e1e01743728f3ed7ec8a7e6ff2","type":"text","conversion_output":true,"text":"infant is 7 and 8 -month-old. The dietary interviews are similar at all stages. We ask the families about","text_display":" infant is 7 and 8 -month-old. The dietary interviews are similar at all stages. We ask the families about","confidence":1,"confidence_rate":1},{"cnt":[[180,1901],[1944,1901],[1944,1955],[180,1955]],"region":{"top_left_x":180,"top_left_y":1901,"width":1765,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d1741bc620640deb3b0c77af45a3991","type":"text","conversion_output":true,"text":"the age at the end of exclusive and total breastfeeding. We have several questions on the use of Study","text_display":" the age at the end of exclusive and total breastfeeding. We have several questions on the use of Study","confidence":1,"confidence_rate":1},{"cnt":[[180,1951],[1944,1951],[1944,2004],[180,2004]],"region":{"top_left_x":180,"top_left_y":1950,"width":1765,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d6b95b5c3eb439187a38a651719378b","type":"text","conversion_output":true,"text":"Formula: Age when the feeding was started and age when regular, daily use started, whether the infant","text_display":" Formula: Age when the feeding was started and age when regular, daily use started, whether the infant","confidence":1,"confidence_rate":1},{"cnt":[[180,1998],[1944,1998],[1944,2052],[180,2052]],"region":{"top_left_x":180,"top_left_y":1998,"width":1765,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7e989faae544d7781010824559c7bba","type":"text","conversion_output":true,"text":"receives Study Formula at the time of the interview, how much Study Formula the infant is receiving per","text_display":" receives Study Formula at the time of the interview, how much Study Formula the infant is receiving per","confidence":1,"confidence_rate":1},{"cnt":[[180,2045],[1944,2045],[1944,2099],[180,2099]],"region":{"top_left_x":180,"top_left_y":2045,"width":1765,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04cdcd67be1642afaefcbaaf2ed6ba49","type":"text","conversion_output":true,"text":"feeding, how much Study Formula the family has available at home at the time of the interview, and","text_display":" feeding, how much Study Formula the family has available at home at the time of the interview, and","confidence":1,"confidence_rate":1},{"cnt":[[180,2093],[1949,2093],[1949,2146],[180,2146]],"region":{"top_left_x":180,"top_left_y":2092,"width":1769,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28f947aeba584700a60a1989350aa9ec","type":"text","conversion_output":true,"text":"whether they need more or not. In the interview form we also have questions on the frequency of use of","text_display":" whether they need more or not. In the interview form we also have questions on the frequency of use of","confidence":0.99755859375,"confidence_rate":0.9999771554820448},{"cnt":[[180,2140],[1944,2140],[1944,2194],[180,2194]],"region":{"top_left_x":180,"top_left_y":2139,"width":1765,"height":55},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c455f813282447f1b9ba7ce9f603cf29","type":"text","conversion_output":true,"text":"breast milk, Study Formula and other foods. The frequency of use of foods to be avoided during the","text_display":" breast milk, Study Formula and other foods. The frequency of use of foods to be avoided during the","confidence":1,"confidence_rate":1},{"cnt":[[180,2187],[1944,2187],[1944,2243],[180,2243]],"region":{"top_left_x":180,"top_left_y":2187,"width":1765,"height":56},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5bdd1b73f4d41aaa8086b12b43a4810","type":"text","conversion_output":true,"text":"intervention period is also asked. The Study Centers record the amount of Study Formula given to the","text_display":" intervention period is also asked. The Study Centers record the amount of Study Formula given to the","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[183,2239],[1944,2239],[1944,2292],[183,2292]],"region":{"top_left_x":182,"top_left_y":2238,"width":1763,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b5474349d8345b38f80600ca727bed6","type":"text","conversion_output":true,"text":"family, and all the unused formula must be returned to the local study center the clinical visit closest to","text_display":" family, and all the unused formula must be returned to the local study center the clinical visit closest to","confidence":1,"confidence_rate":1},{"cnt":[[180,2282],[1944,2282],[1944,2340],[180,2340]],"region":{"top_left_x":180,"top_left_y":2281,"width":1765,"height":59},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"758a1bd360254619b49fb91c933d7003","type":"text","conversion_output":true,"text":"the end of the intervention period (at the 6 or 9 month visit). Compliance with the avoidance of CM","text_display":" the end of the intervention period (at the 6 or 9 month visit). Compliance with the avoidance of CM","confidence":1,"confidence_rate":1},{"cnt":[[180,2333],[1944,2333],[1944,2387],[180,2387]],"region":{"top_left_x":180,"top_left_y":2333,"width":1765,"height":54},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d659fd063ea4ca4b620f2d0dabd96c6","type":"text","conversion_output":true,"text":"proteins is also assessed by measuring antibody levels to CM proteins from sera at 3 and 6 months, and","text_display":" proteins is also assessed by measuring antibody levels to CM proteins from sera at 3 and 6 months, and","confidence":0.8604869842529297,"confidence_rate":0.9986711775679661},{"cnt":[[180,2380],[1944,2380],[1944,2434],[180,2434]],"region":{"top_left_x":180,"top_left_y":2380,"width":1765,"height":55},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92ae4c729328433aabf5304bf178fa4e","type":"text","conversion_output":true,"text":"the results are analyzed by the Data Safety and Monitoring Board. We do not intend to employ serum","text_display":" the results are analyzed by the Data Safety and Monitoring Board. We do not intend to employ serum","confidence":1,"confidence_rate":1},{"cnt":[[180,2428],[1351,2428],[1351,2484],[180,2484]],"region":{"top_left_x":180,"top_left_y":2427,"width":1172,"height":57},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"36305b866b6743b3a51fe777131254c6","type":"text","conversion_output":true,"text":"titers of antibodies to CM proteins as a surrogate of islet cell damage.","text_display":" titers of antibodies to CM proteins as a surrogate of islet cell damage.","confidence":0.99951171875,"confidence_rate":0.9999936571565041},{"cnt":[[1912,2582],[1955,2582],[1955,2628],[1912,2628]],"region":{"top_left_x":1912,"top_left_y":2582,"width":44,"height":46},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1350d0d9d9874532aa58367ab7d6fb47","type":"page_info","conversion_output":false,"text":"9","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-11","page":11,"lines":[{"cnt":[[808,125],[1315,125],[1315,174],[808,174]],"region":{"top_left_x":807,"top_left_y":124,"width":508,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a79d8b5c576d41e7ae11b9a20283da38","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[183,296],[1940,296],[1940,346],[183,346]],"region":{"top_left_x":182,"top_left_y":296,"width":1759,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac795b6559b2472bab1bf552cec99807","type":"text","conversion_output":true,"text":"The Nutrition Epidemiology Unit (Dr. Suvi M. Virtanen, National Institute for Health and Welfare,","text_display":"\n\nThe Nutrition Epidemiology Unit (Dr. Suvi M. Virtanen, National Institute for Health and Welfare,","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[183,344],[1944,344],[1944,393],[183,393]],"region":{"top_left_x":182,"top_left_y":343,"width":1763,"height":51},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7f48d5f1f60490ca9d2fba7ccf18e8b","type":"text","conversion_output":true,"text":"Helsinki, Finland) of the International Coordinating Center is responsible for the education and","text_display":" Helsinki, Finland) of the International Coordinating Center is responsible for the education and","confidence":1,"confidence_rate":1},{"cnt":[[183,391],[1944,391],[1944,440],[183,440]],"region":{"top_left_x":182,"top_left_y":391,"width":1763,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73a7e4be45cf4471a7f3b6e31d6da784","type":"text","conversion_output":true,"text":"supervision concerning the assessment and maintenance of the dietary compliance and the dietary advice","text_display":" supervision concerning the assessment and maintenance of the dietary compliance and the dietary advice","confidence":1,"confidence_rate":1},{"cnt":[[183,438],[1944,438],[1944,488],[183,488]],"region":{"top_left_x":182,"top_left_y":438,"width":1763,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b08617b5f6ee4c40b854bdf2b394a272","type":"text","conversion_output":true,"text":"given by the centers involved. A continuous quality control system is implemented in each center for","text_display":" given by the centers involved. A continuous quality control system is implemented in each center for","confidence":1,"confidence_rate":1},{"cnt":[[183,488],[1944,488],[1944,535],[183,535]],"region":{"top_left_x":182,"top_left_y":487,"width":1763,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5219a84fa18a4b0ab198a0d48aada4d2","type":"text","conversion_output":true,"text":"the data collection and content, especially to ensure that the delivery of dietary advice and the","text_display":" the data collection and content, especially to ensure that the delivery of dietary advice and the","confidence":1,"confidence_rate":1},{"cnt":[[183,535],[1944,535],[1944,587],[183,587]],"region":{"top_left_x":182,"top_left_y":534,"width":1763,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3c9bdf5dcbd4577ac270b7ffff2b1db","type":"text","conversion_output":true,"text":"measurement of dietary compliance function properly. A specially trained Study Monitor supervises the","text_display":" measurement of dietary compliance function properly. A specially trained Study Monitor supervises the","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[183,584],[1944,584],[1944,632],[183,632]],"region":{"top_left_x":182,"top_left_y":584,"width":1763,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe3e2f8d25294d9cb500c109697f08e5","type":"text","conversion_output":true,"text":"implementation of these measures. A Nutrition Fellow at the Nutrition Epidemiology Unit oversees the","text_display":" implementation of these measures. A Nutrition Fellow at the Nutrition Epidemiology Unit oversees the","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[183,632],[1944,632],[1944,681],[183,681]],"region":{"top_left_x":182,"top_left_y":631,"width":1763,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7574df2b2ab54c9480e9dce087e1ff91","type":"text","conversion_output":true,"text":"dietary intervention closely supervised by Dr. Virtanen, by means of data collected, reports from the","text_display":" dietary intervention closely supervised by Dr. Virtanen, by means of data collected, reports from the","confidence":1,"confidence_rate":1},{"cnt":[[180,679],[1162,679],[1162,728],[180,728]],"region":{"top_left_x":180,"top_left_y":678,"width":983,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03818746994448fb95a9c53b30b152ea","type":"text","conversion_output":true,"text":"monitors, and continuous contacts with the Study Centers.","text_display":" monitors, and continuous contacts with the Study Centers.","confidence":1,"confidence_rate":1},{"cnt":[[765,819],[1354,819],[1354,870],[765,870]],"region":{"top_left_x":764,"top_left_y":818,"width":590,"height":53},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"229163fea764461f8130340be033eecb","type":"section_header","conversion_output":false,"children_ids":["678deb0519d4473c90564fd538fc990d"],"text":"","text_display":""},{"cnt":[[769,825],[1347,825],[1347,866],[769,866]],"region":{"top_left_x":769,"top_left_y":825,"width":579,"height":41},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"678deb0519d4473c90564fd538fc990d","type":"text","conversion_output":true,"parent_id":"229163fea764461f8130340be033eecb","text":"H. STUDY ASSESSMENTS","text_display":"\n\n\\section*{H. STUDY ASSESSMENTS}","confidence":1,"confidence_rate":1},{"cnt":[[180,915],[346,915],[346,965],[180,965]],"region":{"top_left_x":180,"top_left_y":915,"width":166,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b36263346734872b440f00c6350082b","type":"section_header","conversion_output":false,"children_ids":["f12621508faa409fa79a6fce4ea4579d"],"text":"","text_display":""},{"cnt":[[185,920],[342,920],[342,960],[185,960]],"region":{"top_left_x":184,"top_left_y":919,"width":158,"height":42},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f12621508faa409fa79a6fce4ea4579d","type":"text","conversion_output":true,"parent_id":"5b36263346734872b440f00c6350082b","text":"Baseline","text_display":"\n\n\\section*{Baseline}","confidence":1,"confidence_rate":1},{"cnt":[[183,980],[1944,980],[1944,1029],[183,1029]],"region":{"top_left_x":182,"top_left_y":979,"width":1763,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb3ed369a2794d90ae47294a04cb0906","type":"text","conversion_output":true,"text":"After the delivery medical and perinatal history of the infant and mother (including birth weight and","text_display":"\n\nAfter the delivery medical and perinatal history of the infant and mother (including birth weight and","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[180,1027],[1944,1027],[1944,1076],[180,1076]],"region":{"top_left_x":180,"top_left_y":1026,"width":1765,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e22bfb84f55e4b9eba8fff14232831d0","type":"text","conversion_output":true,"text":"gestational age) and the results of the newborn physical examination are recorded on the case report","text_display":" gestational age) and the results of the newborn physical examination are recorded on the case report","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[180,1076],[299,1076],[299,1119],[180,1119]],"region":{"top_left_x":180,"top_left_y":1076,"width":119,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9eddefcfc06452582240998df937ce7","type":"text","conversion_output":true,"text":"forms.","text_display":" forms.","confidence":1,"confidence_rate":1},{"cnt":[[178,1229],[1042,1229],[1042,1287],[178,1287]],"region":{"top_left_x":178,"top_left_y":1228,"width":864,"height":59},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdc714469a914ddba51c58a3f2fe2011","type":"section_header","conversion_output":false,"children_ids":["724d3cb5c1e04c25bc70f7886fedf726"],"text":"","text_display":""},{"cnt":[[185,1233],[1038,1233],[1038,1283],[185,1283]],"region":{"top_left_x":184,"top_left_y":1233,"width":854,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"724d3cb5c1e04c25bc70f7886fedf726","type":"text","conversion_output":true,"parent_id":"cdc714469a914ddba51c58a3f2fe2011","text":"Follow-up Period during and after Intervention","text_display":"\n\n\\section*{Follow-up Period during and after Intervention}","confidence":1,"confidence_rate":1},{"cnt":[[183,1296],[1944,1296],[1944,1345],[183,1345]],"region":{"top_left_x":182,"top_left_y":1295,"width":1763,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e321aec50a04a3d9337063c77dfd5bd","type":"text","conversion_output":true,"text":"The subjects visit the research center or have a home visit at the age of \\(3,6,9,12,18\\) and 24 months,","text_display":"\n\nThe subjects visit the research center or have a home visit at the age of \\(3,6,9,12,18\\) and 24 months,","confidence":0.9931747852835997,"confidence_rate":0.9999383026869542},{"cnt":[[183,1345],[1515,1345],[1515,1394],[183,1394]],"region":{"top_left_x":182,"top_left_y":1344,"width":1333,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42eaf76593f24693be5a91d34034d168","type":"text","conversion_output":true,"text":"and at \\(3,4,5,6,7,8,9\\) and 10 years of age, or when clinical diabetes develops.","text_display":" and at \\(3,4,5,6,7,8,9\\) and 10 years of age, or when clinical diabetes develops.","confidence":0.9980475902557373,"confidence_rate":0.9999777920854561},{"cnt":[[183,1439],[1944,1439],[1944,1489],[183,1489]],"region":{"top_left_x":182,"top_left_y":1439,"width":1763,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04e09f839bc74216b3b8b51791e2ae03","type":"text","conversion_output":true,"text":"Protocol change in 2011: The follow-up of the subjects will be continued until the youngest participant","text_display":"\n\nProtocol change in 2011: The follow-up of the subjects will be continued until the youngest participant","confidence":0.9795856475830078,"confidence_rate":0.9998090404081132},{"cnt":[[180,1487],[1944,1487],[1944,1536],[180,1536]],"region":{"top_left_x":180,"top_left_y":1486,"width":1765,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bc496907cec4586ab8895d75f9e1d82","type":"text","conversion_output":true,"text":"reaches the age of 10 years. The oldest participants will then be 14 -year old. During the prolonged","text_display":" reaches the age of 10 years. The oldest participants will then be 14 -year old. During the prolonged","confidence":0.9736328125,"confidence_rate":0.9997592989223644},{"cnt":[[183,1534],[1944,1534],[1944,1583],[183,1583]],"region":{"top_left_x":182,"top_left_y":1533,"width":1763,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f794b487a9b4f0f930e036acdefd8cc","type":"text","conversion_output":true,"text":"follow-up period the follow-visits will take place annually at the ages of 11, 12, 13 and 14 years. The","text_display":" follow-up period the follow-visits will take place annually at the ages of 11, 12, 13 and 14 years. The","confidence":0.8913724422454834,"confidence_rate":0.9989917986287392},{"cnt":[[180,1581],[1944,1581],[1944,1631],[180,1631]],"region":{"top_left_x":180,"top_left_y":1581,"width":1765,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8569d051fe3a4335ac669c4347b63bfa","type":"text","conversion_output":true,"text":"presence or absence of diabetes is determined according to the criteria outlined below (see Outcome","text_display":" presence or absence of diabetes is determined according to the criteria outlined below (see Outcome","confidence":1,"confidence_rate":1},{"cnt":[[180,1629],[1946,1629],[1946,1680],[180,1680]],"region":{"top_left_x":180,"top_left_y":1628,"width":1767,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eca89e49cde44972a953806a975d7e2e","type":"text","conversion_output":true,"text":"Assessment, below). Clinical findings at each visit (e.g. weight, height) are recorded on the case report","text_display":" Assessment, below). Clinical findings at each visit (e.g. weight, height) are recorded on the case report","confidence":1,"confidence_rate":1},{"cnt":[[180,1680],[299,1680],[299,1721],[180,1721]],"region":{"top_left_x":180,"top_left_y":1680,"width":119,"height":41},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"686e17f4df6d4a75900252812d29d19a","type":"text","conversion_output":true,"text":"forms.","text_display":" forms.","confidence":1,"confidence_rate":1},{"cnt":[[183,1775],[1944,1775],[1944,1824],[183,1824]],"region":{"top_left_x":182,"top_left_y":1774,"width":1763,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bf0826869004c24b1f3f3d4b3e569cf","type":"text","conversion_output":true,"text":"Protocol Change in 2015: Puberty will be assessed based on hormonal analyses. Serum estradiol will be","text_display":"\n\nProtocol Change in 2015: Puberty will be assessed based on hormonal analyses. Serum estradiol will be","confidence":1,"confidence_rate":1},{"cnt":[[183,1822],[1944,1822],[1944,1871],[183,1871]],"region":{"top_left_x":182,"top_left_y":1821,"width":1763,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"234acb8bcff64ec9ab60c36bbef1753f","type":"text","conversion_output":true,"text":"analyzed in girls and serum testosterone in boys starting from the age of 8 years. In addition girls will be","text_display":" analyzed in girls and serum testosterone in boys starting from the age of 8 years. In addition girls will be","confidence":1,"confidence_rate":1},{"cnt":[[180,1869],[1944,1869],[1944,1919],[180,1919]],"region":{"top_left_x":180,"top_left_y":1869,"width":1765,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc2ede28aa5c4d01ac7543f5e910d293","type":"text","conversion_output":true,"text":"asked about their age at menarche and the use of medication containing estrogens and/or androgens","text_display":" asked about their age at menarche and the use of medication containing estrogens and/or androgens","confidence":1,"confidence_rate":1},{"cnt":[[183,1919],[741,1919],[741,1968],[183,1968]],"region":{"top_left_x":182,"top_left_y":1918,"width":560,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57bfbb610d414429a5c05f43503bbc36","type":"text","conversion_output":true,"text":"starting from the age of 10 years.","text_display":" starting from the age of 10 years.","confidence":1,"confidence_rate":1},{"cnt":[[180,2013],[1944,2013],[1944,2065],[180,2065]],"region":{"top_left_x":180,"top_left_y":2013,"width":1765,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fca070e31cb742f699ab082a77dab570","type":"text","conversion_output":true,"text":"Blood for serology (diabetes-associated autoantibodies and CM antibodies) is drawn after the","text_display":"\n\nBlood for serology (diabetes-associated autoantibodies and CM antibodies) is drawn after the","confidence":1,"confidence_rate":1},{"cnt":[[180,2062],[1944,2062],[1944,2112],[180,2112]],"region":{"top_left_x":180,"top_left_y":2062,"width":1765,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cda88f0008414674a352aa39337cb931","type":"text","conversion_output":true,"text":"application of an analgesic ointment on the venipuncture site at the above mentioned visits and serum","text_display":" application of an analgesic ointment on the venipuncture site at the above mentioned visits and serum","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[180,2110],[1944,2110],[1944,2159],[180,2159]],"region":{"top_left_x":180,"top_left_y":2109,"width":1765,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f93d05bbdf6a4bc7896c44e88c0c5d34","type":"text","conversion_output":true,"text":"samples are stored centrally. In addition, the 3 and 6 month serum samples are available for use in the","text_display":" samples are stored centrally. In addition, the 3 and 6 month serum samples are available for use in the","confidence":0.998046875,"confidence_rate":0.9999828507186663},{"cnt":[[180,2157],[1944,2157],[1944,2206],[180,2206]],"region":{"top_left_x":180,"top_left_y":2157,"width":1765,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"052d05fe38924d8b91a0a3d1de1ab5e0","type":"text","conversion_output":true,"text":"assessment of dietary compliance. All serum samples are aliquoted, and the samples are stored at \\(-70 C ^{\\circ}\\)","text_display":" assessment of dietary compliance. All serum samples are aliquoted, and the samples are stored at \\(-70 C ^{\\circ}\\)","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[180,2204],[1944,2204],[1944,2254],[180,2254]],"region":{"top_left_x":180,"top_left_y":2204,"width":1765,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a5c6c77a569406d93283415f9adcb3a","type":"text","conversion_output":true,"text":"in the TRIGR Core Laboratory in Helsinki. Local measurement of plasma glucose and glycated","text_display":" in the TRIGR Core Laboratory in Helsinki. Local measurement of plasma glucose and glycated","confidence":1,"confidence_rate":1},{"cnt":[[180,2254],[1944,2254],[1944,2305],[180,2305]],"region":{"top_left_x":180,"top_left_y":2253,"width":1765,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d954adb29484c3581ebc3743f05a3ed","type":"text","conversion_output":true,"text":"hemoglobin takes place at \\(12,18,24\\) months, and \\(3,4,5,6,7,8,9\\) and 10 years. During the prolonged","text_display":" hemoglobin takes place at \\(12,18,24\\) months, and \\(3,4,5,6,7,8,9\\) and 10 years. During the prolonged","confidence":0.97607421875,"confidence_rate":0.9997778535620372},{"cnt":[[180,2299],[1944,2299],[1944,2353],[180,2353]],"region":{"top_left_x":180,"top_left_y":2298,"width":1765,"height":55},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b4515cdaf904a3e949c7f6e74e32175","type":"text","conversion_output":true,"text":"follow-up period these measurements will be performed at the age of 11, 12, 13 and 14 years. The","text_display":" follow-up period these measurements will be performed at the age of 11, 12, 13 and 14 years. The","confidence":0.8019936853088439,"confidence_rate":0.9979399328493432},{"cnt":[[180,2350],[1944,2350],[1944,2400],[180,2400]],"region":{"top_left_x":180,"top_left_y":2350,"width":1765,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc597408da7e4f20a804f399ceb552b9","type":"text","conversion_output":true,"text":"specimens for plasma glucose are preferentially taken 1-2 hours postprandially. If the glycated","text_display":" specimens for plasma glucose are preferentially taken 1-2 hours postprandially. If the glycated","confidence":0.99560546875,"confidence_rate":0.999955958813992},{"cnt":[[180,2398],[1944,2398],[1944,2447],[180,2447]],"region":{"top_left_x":180,"top_left_y":2397,"width":1765,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"648e3d0d1696400a90629b41f614af33","type":"text","conversion_output":true,"text":"hemoglobin is higher than the reference range, an OGTT may be required to confirm the diagnosis as","text_display":" hemoglobin is higher than the reference range, an OGTT may be required to confirm the diagnosis as","confidence":0.9990234375,"confidence_rate":0.9999905142231666},{"cnt":[[180,2445],[1944,2445],[1944,2494],[180,2494]],"region":{"top_left_x":180,"top_left_y":2444,"width":1765,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a6b06c2e09e44af8c81e6ebe6c9f615","type":"text","conversion_output":true,"text":"below. An OGTT will be performed at the age of 6 and 10 years in all study subjects. In addition, an","text_display":" below. An OGTT will be performed at the age of 6 and 10 years in all study subjects. In addition, an","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[1899,2582],[1955,2582],[1955,2628],[1899,2628]],"region":{"top_left_x":1899,"top_left_y":2582,"width":57,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8946c0a19b0e4062a0a09541ab924341","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-12","page":12,"lines":[{"cnt":[[804,125],[1317,125],[1317,176],[804,176]],"region":{"top_left_x":803,"top_left_y":124,"width":514,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9239bb746ee74108bcb763c3ea799aad","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,243],[1944,243],[1944,299],[180,299]],"region":{"top_left_x":180,"top_left_y":242,"width":1765,"height":57},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"172997e63471477b9b84cb046faae068","type":"text","conversion_output":true,"text":"OGTT will be performed in all study subjects at the last follow-up visit in 2016-2017. A heparin blood","text_display":"\n\nOGTT will be performed in all study subjects at the last follow-up visit in 2016-2017. A heparin blood","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1949,294],[1949,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1769,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1448833b62e64d989478a5fcaf23d166","type":"text","conversion_output":true,"text":"sample ( \\(3-5 ml\\) blood depending on age) is obtained at each sampling time for the isolation of","text_display":" sample ( \\(3-5 ml\\) blood depending on age) is obtained at each sampling time for the isolation of","confidence":0.9960954189300537,"confidence_rate":0.9999623831705339},{"cnt":[[183,344],[1944,344],[1944,393],[183,393]],"region":{"top_left_x":182,"top_left_y":343,"width":1763,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad55cdbe017d4c6f8cdb802967191993","type":"text","conversion_output":true,"text":"mononuclear cells. These cells are sent fresh to central labs (Professors Outi Vaarala, Helsinki, Finland","text_display":" mononuclear cells. These cells are sent fresh to central labs (Professors Outi Vaarala, Helsinki, Finland","confidence":1,"confidence_rate":1},{"cnt":[[183,391],[1944,391],[1944,440],[183,440]],"region":{"top_left_x":182,"top_left_y":391,"width":1763,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"957c796b45b34050aa3110678cd222fe","type":"text","conversion_output":true,"text":"and Hans-Michael Dosch, Toronto, ON, Canada) and used for mechanistic studies. An EDTA blood","text_display":" and Hans-Michael Dosch, Toronto, ON, Canada) and used for mechanistic studies. An EDTA blood","confidence":1,"confidence_rate":1},{"cnt":[[183,438],[1944,438],[1944,490],[183,490]],"region":{"top_left_x":182,"top_left_y":438,"width":1763,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d2e0d5ac6384a98b7f6c53d776e44be","type":"text","conversion_output":true,"text":"sample, 4 ml , for DNA extraction will be collected from all study participants. Samples will be obtained","text_display":" sample, 4 ml , for DNA extraction will be collected from all study participants. Samples will be obtained","confidence":1,"confidence_rate":1},{"cnt":[[183,486],[1944,486],[1944,539],[183,539]],"region":{"top_left_x":182,"top_left_y":485,"width":1763,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9117f756a29c4a8e937b7ff81e0d401f","type":"text","conversion_output":true,"text":"in association of collection of blood samples for autoantibody analyses once at the age of 5 years or","text_display":" in association of collection of blood samples for autoantibody analyses once at the age of 5 years or","confidence":0.9990236759185791,"confidence_rate":0.9999910385631244},{"cnt":[[183,535],[1944,535],[1944,587],[183,587]],"region":{"top_left_x":182,"top_left_y":534,"width":1763,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"59729aaafb5b419097a07d7a0f94eca0","type":"text","conversion_output":true,"text":"later. In the case of children who already have developed type 1 diabetes or have dropped-out from the","text_display":" later. In the case of children who already have developed type 1 diabetes or have dropped-out from the","confidence":1,"confidence_rate":1},{"cnt":[[185,580],[1139,580],[1139,634],[185,634]],"region":{"top_left_x":184,"top_left_y":580,"width":955,"height":54},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0f2646d50b54066a592d3962689e4cf","type":"text","conversion_output":true,"text":"follow-up a separate sample will be collected if possible.","text_display":" follow-up a separate sample will be collected if possible.","confidence":1,"confidence_rate":1},{"cnt":[[180,675],[1944,675],[1944,728],[180,728]],"region":{"top_left_x":180,"top_left_y":674,"width":1765,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a98e1a2a40441bd8502547e7c379d97","type":"text","conversion_output":true,"text":"Protocol Change in 2015: After TRIGR, any remaining samples will be placed into the National","text_display":"\n\nProtocol Change in 2015: After TRIGR, any remaining samples will be placed into the National","confidence":1,"confidence_rate":1},{"cnt":[[183,726],[1944,726],[1944,778],[183,778]],"region":{"top_left_x":182,"top_left_y":726,"width":1763,"height":52},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d3bdabfb2284cf69504ff2cb7085f79","type":"text","conversion_output":true,"text":"Institutes of Health (NIH) repository for future studies related to type 1 diabetes and its complications.","text_display":" Institutes of Health (NIH) repository for future studies related to type 1 diabetes and its complications.","confidence":0.996584415435791,"confidence_rate":0.9999699878978318},{"cnt":[[183,773],[1944,773],[1944,827],[183,827]],"region":{"top_left_x":182,"top_left_y":773,"width":1763,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cdfc456a4bd43b386b91ea2298e76a5","type":"text","conversion_output":true,"text":"They will be stored there indefinitely without names or any other identifying information on them.","text_display":" They will be stored there indefinitely without names or any other identifying information on them.","confidence":1,"confidence_rate":1},{"cnt":[[183,821],[1944,821],[1944,874],[183,874]],"region":{"top_left_x":182,"top_left_y":820,"width":1763,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0a713a4e9da4ed3bd684aa0d58ced26","type":"text","conversion_output":true,"text":"Once the samples are in the repository, subjects will not be able to have them removed. Researchers","text_display":" Once the samples are in the repository, subjects will not be able to have them removed. Researchers","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[180,868],[1439,868],[1439,922],[180,922]],"region":{"top_left_x":180,"top_left_y":867,"width":1260,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf3bd8cc135a4b38a1bd828127fd1124","type":"text","conversion_output":true,"text":"must first get permission from the NIH to use samples from the repository.","text_display":" must first get permission from the NIH to use samples from the repository.","confidence":1,"confidence_rate":1},{"cnt":[[180,962],[1334,962],[1334,1018],[180,1018]],"region":{"top_left_x":180,"top_left_y":962,"width":1155,"height":57},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cd62d5525d54860b49fb981f555b369","type":"text","conversion_output":true,"text":"A summary and timetable of the various events are given in Table 3.","text_display":"\n\nA summary and timetable of the various events are given in Table 3.","confidence":0.993659496307373,"confidence_rate":0.9999104168288792},{"cnt":[[1899,2582],[1946,2582],[1946,2625],[1899,2625]],"region":{"top_left_x":1899,"top_left_y":2582,"width":48,"height":44},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"949d4fda490e477f828b60356f887e41","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-13","page":13,"lines":[{"cnt":[[1439,150],[1951,150],[1951,200],[1439,200]],"region":{"top_left_x":1439,"top_left_y":150,"width":512,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"395947027a374f5c8dea92d15e3542c1","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[90,202],[501,202],[501,254],[90,254]],"region":{"top_left_x":90,"top_left_y":201,"width":411,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60ce82c8a8404f80b675036dea2563b9","type":"figure_label","conversion_output":false,"text":"Table 3. Study schedule","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[140,264],[2488,264],[2488,1545],[140,1545]],"region":{"top_left_x":139,"top_left_y":264,"width":2349,"height":1281},"line":3,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"0795d243f4414a8587a650834248741d","type":"table","conversion_output":true,"children_ids":["c8a2f4b348134a2ba1623fc7008447c7","f7149976ce3949d4b5dba6d95f7fed0d","7bb7edfe435149aa9b7b904260dd1191","81a2fcddb5644d86a7c1af0221506aa2","658a7ef9e17740479bd2750545813bdd","b988518b5918449d8a2a891494e9f42a","7ee8200a3abf4a4796d7af6f73f38749","38ed01f7725f4fe799806c44f34f22d7","eac3ca41e2f1474494621065238700bf","97983f9f95f647d69c327fdb1e4657b9","a2ab2a88807747d5b0853f18caf82194","980e882915e94842989326a53842117c","769849554ba6400f9e88f2808766e865","53691dd5574544b1ba29d814963676de","e3841ce20feb48f780a44ef7799fbc0b","1c115ae553bc4dd7ae045473c9487904","bf70672bef61461ca958b4b461485c57","9190ae1afaa64122bf60a2d8726ab5f1","53504d1df49c42b6826ff600d1c02fe2","2977bcb0fcc1402ea0afc123a8db29a4","a9a1d05b5540429888a113b092ef78d8","8a11c70b296f4d05ba9fa09d1104bd8e","d83e9aac38b84cd7bf82999129fc2dda","451501fa189b42bb8335388911e90cac","de46c723798a46019278fc68e8fcb67d","f4e8a2cc0cac4872834dfb8f539c21fe","5ebf1405b1594f95b58f8fae9bb24315","e9c4f9106c15440cb7b972683505d9f0","40e619a47d67480bb13755d450d659a0","b6ba838ff4ad4455ac4eb9fd1e564070","13ea3ae8ac4a4fa7a4cd3f25d69b9ae4","c0deb0542c3d40da8d2c692ae59c1e49","de9bfd91edb6426ba8d0ea96282e5f6d","353d1d6adb2c45b4a4d04ce4fb5b582e","00f76a043049484cbb0687baaa4e5f68","b5beeca8da30484da908c0ab3bd1099c","ccf90905c7c34276b822424c8458506d","00eb4eea80bd4177b5f30edb56f3aa0f","96027e08442445e9aa8396ca126808ed","e14f8fc7f3d04a4d8bcad8f3ffaf4a4b","7c6be852841f4988b1b0f0ccba8b9ac8","fca4b98761e64497b6fda2d67498e36d","a32b1a59e0f6452eb762cb271db18e56","b09b5479b8b9447b83318d599072e4d7","97f25c9beb504b21b14188ddf0833f57","31b414000ecb4b38babb707a11ba3f5e","5b9693f95aab454e8f10664e6e9eaf73","a043c4e82a95424ab28439f491160760","82a6771026684af89226a8762d5330f5","87a2c66bc6f44045965754eae5d96ed9","37f55acd957b403ca08af32dab929f20","7ad5d7a38ff8488e9428224b7dc16f12","0809a76bc3934d66a99e27551312d57d","9e55e7e9de0044e48072f9d9ad58d79f","2ff74244554e4f908863fa3691d1a51d","83bdeb199f494b91bcc3b51561031f5d","7b49e54552fa4229b1974751dc5a1e32","a63b61d18b5e4f8fb7008b11ab29c40e","2595e5fd0540439fa346d4f1474c0925","f7c6a0b0d508448788e38ecec2fa1e0c","6d73ca6f0cd04b20aa12af243684c328","a08294a737b048c38a594530a0b0397b","35d01a6c50fb4414b68e32c45ad7b6b2","ecd8b645328d442ba0bd259a23c19e9b","57d46f024e954874a4572495f63804bb","32e8a481b218443da12d18c364712458","b6cce0f991de480c88b15aa777bb50da","ce4e514dae014f9a9f6bdb6bcc3e4897","8632e8feadcc4c0da05976d983a87a28","e49f7db937f64df98aa8f330609f02f2","0e8421f5b1a649efa05ec899e4cf3a0e","d7edc2dd028e4c23b549a806393e5efc","92994546987b4a4484ca37085628d556","d8c078fa2c224c89950d52d86f82fa23","5babf5736f844804905603141232795c","dae2b1ce1ce3429898bd392a1bf53ae5","f1d085ed58b4416292823e84404af8ca","535bdcd856f94e48826d49b65fedfe59","1e835f05e0fa4e0b9134a7c3640839ee","4f6f802d2e744e93a877f6c73794b16b","bd7c78091fbb462195f4ab7730573d7a","315c44104c1445ceab87e1a736eb47ce","646352beda864b1cb9a03cd10ec65f2b","0ad6f13c11214fa39b9e421a43afbb01","91ef45e3fd7d4ffd8c267548d16c75b3","2d97fc7733934c109e3c860aba75f884","8f18fb98d4e4460b8e2ccb16668a3b9a","a013c7578f444bf5b49fe6c475364335","99ce28668df54bda825e86bb2bfbe2b9","2eb334c7a4d145fcac377fb325b8a751","fd25ae72e0b34679bf752fba1c830f65","27bbbb5972e845afa3808a25af979918","79c6d7d64cb64ae980c12397fe833e1b","36f9e7e58e644ebb8d48ba111cd6fc7a","aac70fc82e4c43408a85d42499551d1f","a7c3423d2feb43a6963b023f96beb54f","49111f8b60e0404db026137e263df361","0e33202d64cb49768c9e6b7ce7987fd0","310da70907c14b3aa547ede3e4bf37d4","622dd3882cfc4fa5bbf9734fb93b67aa","5b96b7ecb2a041c0ab2efe35c5ee09be","eebfb81015a54a4a8833b9d14eda792d","963b342e28ec42d2809108b18794207a","a0c8db2a62884c3bbd3e97a0b86c6ecd","869c79b2e1594007a5ef7d39557cf6a4","aeba46ce81314ec7a76cd08f7846e85e","d1ee867779e644fcb72e335e5ff411c6","927f83b7484f47a881214d35c1b1352d","a83b4d4a1138443191f3e2d6c0e8283c","91b93cef41254d5496558ce2f3a89f59","a6dcee7e2195456aa6a4bf064d068bc7","33ca27075cb447df9b97a9b7efde2885","85ac6a21edeb43409bb19e9eeda9efd5","3f9e821f7d90406d82cddf1bd11070a3","79615dd7e45544b592b7c8855d6b3ba4","b3bd269e415e48c18c8ae9dfec73cacf","0630b46e5aa6410284de2b4e95c273f4","df865b4b0c0049e59e5d8efd5199af88","62a8870cbba746fc948c7cb9464611c5","bb79766d52cd4dc7a3f84b5b3e103517","046b782fcfe3460a8bd0086f893091e8","c96016786f4f446bb7717d44a26ba0dd","980c9d2c27e545019b0787ab499b6188","2b7d11dbc91847f9b671308c8cfa14e3","eba841c4fb044da7a300e7ca9c3d91a1","a894a3dbaf244e50899757c283aec8ea","02ee2d21addc4a11becf437526071a6c","45b8387fd43c4ab9a8ffc5eb39d8639c","87c432a2bc35416abef20cbfd5eb87fc","333c7516a5df4c0b833d8045a9d86916","9e46b3ffacc642599c4b5a4ba1af16e4","6df2a20f0fc549e8bf7582fa5855789b","ef78a2891d314c6086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\\multirow{2}{*}{} & & \\(1 / 2 , 1 , 2 ~ m o\\) & 3 mo & \\(4 , 5 ~ m o\\) & 6 mo & 7 mo & 8 mo & 9 mo & \\(1 2 ~ m o\\) & 18 mo & 2 yr & \\(3 ~ y r\\) & 4 yr & \\(5 ~ y r\\) & \\(6 ~ y r\\) & \\(7 ~ y r\\) & \\(8 ~ y r\\) & \\(9 ~ y r\\) & 10 yr & 11-14yr \\\\\n\\hline & \\(0 mo ^{*}\\) & Call & Visit & Call & Visit & Call & Call & Visit & Visit & Visit & Visit & Visit & Visit & Visit & Visit & Visit & Visit & Visit & Visit & Visit \\\\\n\\hline Contact number & 1 & 2-4 & 5 & 6-7 & 8 & 8B & 8C & 9 & 10 & 11 & 12 & 13 & 14 & 15 & 16 & 17 & 18 & 19 & 20 & 21-24 \\\\\n\\hline Weight and height & X & & X & & X & & & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline Blood Specimens & & & & & & & & & & & & & & & & & & & & \\\\\n\\hline - Cord blood & X & & & & & & & & & & & & & & & & & & & \\\\\n\\hline - Venous blood & & & X & & X & & & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline - Heparin blood & & & X & & X & & & X & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline - Blood glucose & & & & & & & & & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline - HbA1c & & & & & & & & & X & X & X & X & X & X & X & X & X & X & X & X \\\\\n\\hline - EDTA blood & & & & & & & & & & & & & & X*** & \\(X ^{* * *}\\) & X*** & X*** & X*** & \\(X ^{* * *}\\) & \\\\\n\\hline Dietary Interview & X & X & X & X & X & X & X & X & & & & & & & & & & & & \\\\\n\\hline Dietary counselling & X & X & X & X & X & X & X & & & & & & & & & & & & & \\\\\n\\hline Delivery of Study Formula & X & + When & needed & & & & & & & & & & & & & & & & & \\\\\n\\hline Examination by Study & X & & X & & X & & & & X & & X & & & & X & & & & X & \\(X ^{* *}\\) \\\\\n\\hline OGTT & & & & & & & & & & & & & & & X & & & & X & \\(X ^{* *}\\) \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3. 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There should be","confidence":1,"confidence_rate":1},{"cnt":[[305,1323],[1300,1323],[1300,1369],[305,1369]],"region":{"top_left_x":305,"top_left_y":1323,"width":995,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba2b756e593d4cfaaf29d854259b1545","type":"text","conversion_output":true,"text":"an interval of at least one week between these two OGTTs.","text_display":" an interval of at least one week between these two OGTTs.","confidence":1,"confidence_rate":1},{"cnt":[[180,1418],[1944,1418],[1944,1470],[180,1470]],"region":{"top_left_x":180,"top_left_y":1417,"width":1765,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcc4960db6df4d4a9232a747d4f88687","type":"text","conversion_output":true,"text":"The diabetes-associated autoantibody data will be disclosed when the autoantibodies have been assayed","text_display":"\n\nThe diabetes-associated autoantibody data will be disclosed when the autoantibodies have been assayed","confidence":1,"confidence_rate":1},{"cnt":[[180,1465],[1944,1465],[1944,1519],[180,1519]],"region":{"top_left_x":180,"top_left_y":1465,"width":1765,"height":54},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60e7aeed5d0a47c88f71e1570adce48a","type":"text","conversion_output":true,"text":"after the 6 -year visit, and the family will be informed by the Study Center as soon as the autoantibody","text_display":" after the 6 -year visit, and the family will be informed by the Study Center as soon as the autoantibody","confidence":0.63671875,"confidence_rate":0.9959775115774566},{"cnt":[[180,1517],[698,1517],[698,1562],[180,1562]],"region":{"top_left_x":180,"top_left_y":1516,"width":519,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1218e83389546fa914800735fbb1d65","type":"text","conversion_output":true,"text":"results have become available.","text_display":" results have become available.","confidence":1,"confidence_rate":1},{"cnt":[[649,1607],[1472,1607],[1472,1661],[649,1661]],"region":{"top_left_x":648,"top_left_y":1607,"width":824,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be5f6561a0cb45f49f30f6dc5df9ea50","type":"section_header","conversion_output":false,"children_ids":["06f9248160a94203993010f8d9e8d2ca"],"text":"","text_display":""},{"cnt":[[649,1611],[1467,1611],[1467,1656],[649,1656]],"region":{"top_left_x":648,"top_left_y":1611,"width":820,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06f9248160a94203993010f8d9e8d2ca","type":"text","conversion_output":true,"parent_id":"be5f6561a0cb45f49f30f6dc5df9ea50","text":"I. METHODOLOGY TO BE APPLIED","text_display":"\n\n\\section*{I. METHODOLOGY TO BE APPLIED}","confidence":1,"confidence_rate":1},{"cnt":[[176,1704],[829,1704],[829,1764],[176,1764]],"region":{"top_left_x":176,"top_left_y":1703,"width":654,"height":61},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c21cc2403a3c40b994f22aa865d81836","type":"section_header","conversion_output":false,"children_ids":["16b32b26a0ad43988098dc46d70233b5"],"text":"","text_display":""},{"cnt":[[183,1710],[823,1710],[823,1760],[183,1760]],"region":{"top_left_x":182,"top_left_y":1710,"width":641,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16b32b26a0ad43988098dc46d70233b5","type":"text","conversion_output":true,"parent_id":"c21cc2403a3c40b994f22aa865d81836","text":"Methodology for Genetic Screening","text_display":"\n\n\\section*{Methodology for Genetic Screening}","confidence":1,"confidence_rate":1},{"cnt":[[180,1766],[1944,1766],[1944,1818],[180,1818]],"region":{"top_left_x":180,"top_left_y":1766,"width":1765,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce1a183ae7d943a29742f53cdd5e198c","type":"text","conversion_output":true,"text":"The procedures used for HLA-DQ typing were specifically developed for screening relevant DQB1 and","text_display":"\n\nThe procedures used for HLA-DQ typing were specifically developed for screening relevant DQB1 and","confidence":1,"confidence_rate":1},{"cnt":[[180,1815],[1944,1815],[1944,1867],[180,1867]],"region":{"top_left_x":180,"top_left_y":1815,"width":1765,"height":52},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a91c1a4cb6f40c99a47b4036f4ab8aa","type":"text","conversion_output":true,"text":"DQA1 alleles (11, 12). EDTA treated cord blood is collected. Alternatively capillary blood is taken","text_display":" DQA1 alleles (11, 12). EDTA treated cord blood is collected. Alternatively capillary blood is taken","confidence":0.998046875,"confidence_rate":0.9999812017648063},{"cnt":[[180,1865],[1944,1865],[1944,1914],[180,1914]],"region":{"top_left_x":180,"top_left_y":1864,"width":1765,"height":51},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db8783ba91dd40368fe558a472379249","type":"text","conversion_output":true,"text":"postnatally if cord blood is not available. The blood samples are sent by air mail or special delivery from","text_display":" postnatally if cord blood is not available. The blood samples are sent by air mail or special delivery from","confidence":0.9970729344058782,"confidence_rate":0.9999738275047518},{"cnt":[[180,1912],[1949,1912],[1949,1962],[180,1962]],"region":{"top_left_x":180,"top_left_y":1912,"width":1769,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aa5793977bc4d9693a53f8337f0c58b","type":"text","conversion_output":true,"text":"the U.S. and Canadian centers to the tissue typing laboratory of Professor M. Trucco, University of","text_display":" the U.S. and Canadian centers to the tissue typing laboratory of Professor M. Trucco, University of","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[180,1959],[1949,1959],[1949,2013],[180,2013]],"region":{"top_left_x":180,"top_left_y":1959,"width":1769,"height":55},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"076f9c6eaa434c4bb57b76d8f753201c","type":"text","conversion_output":true,"text":"Pittsburgh, PA, USA, and from the various European and other centers to the tissue typing laboratory of","text_display":" Pittsburgh, PA, USA, and from the various European and other centers to the tissue typing laboratory of","confidence":1,"confidence_rate":1},{"cnt":[[180,2007],[1944,2007],[1944,2058],[180,2058]],"region":{"top_left_x":180,"top_left_y":2006,"width":1765,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d072715254c49078ea994afe1e8c632","type":"text","conversion_output":true,"text":"Dr. J. Ilonen, University of Turku, Finland. According to experiences from the Pilot-2 study of the","text_display":" Dr. J. Ilonen, University of Turku, Finland. According to experiences from the Pilot-2 study of the","confidence":1,"confidence_rate":1},{"cnt":[[180,2056],[1944,2056],[1944,2108],[180,2108]],"region":{"top_left_x":180,"top_left_y":2056,"width":1765,"height":52},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8cde4bdbda14221a72d9b86ec41ddf1","type":"text","conversion_output":true,"text":"project (Finland, Sweden, Estonia and Hungary), the result of the genetic screening is available within 2","text_display":" project (Finland, Sweden, Estonia and Hungary), the result of the genetic screening is available within 2","confidence":1,"confidence_rate":1},{"cnt":[[180,2105],[1944,2105],[1944,2155],[180,2155]],"region":{"top_left_x":180,"top_left_y":2105,"width":1765,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5b3825f256b48b1ad06c802996ab450","type":"text","conversion_output":true,"text":"weeks to assess the eligibility of the infants. The results are entered into the Central Data Base","text_display":" weeks to assess the eligibility of the infants. The results are entered into the Central Data Base","confidence":1,"confidence_rate":1},{"cnt":[[180,2151],[1373,2151],[1373,2202],[180,2202]],"region":{"top_left_x":180,"top_left_y":2150,"width":1193,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88467dbaa3a248f7ac7fa5fb4a4c5e2d","type":"text","conversion_output":true,"text":"immediately when available, and the Study Center is alerted by e-mail.","text_display":" immediately when available, and the Study Center is alerted by e-mail.","confidence":1,"confidence_rate":1},{"cnt":[[180,2247],[1944,2247],[1944,2297],[180,2297]],"region":{"top_left_x":180,"top_left_y":2247,"width":1765,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee3f78fb3f4340cd8beb70b1dd796bd4","type":"text","conversion_output":true,"text":"The polymorphic gene region is amplified in a microtiter format using biotinylated primers. The","text_display":"\n\nThe polymorphic gene region is amplified in a microtiter format using biotinylated primers. The","confidence":1,"confidence_rate":1},{"cnt":[[180,2295],[1944,2295],[1944,2346],[180,2346]],"region":{"top_left_x":180,"top_left_y":2294,"width":1765,"height":53},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e15a2deecee4e0b96456d0113f17360","type":"text","conversion_output":true,"text":"amplification product is subsequently transferred to streptavidin coated microtiter plates where it is","text_display":" amplification product is subsequently transferred to streptavidin coated microtiter plates where it is","confidence":1,"confidence_rate":1},{"cnt":[[180,2342],[1944,2342],[1944,2396],[180,2396]],"region":{"top_left_x":180,"top_left_y":2341,"width":1765,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db83c6ac6a9149d7931b6b188da4816b","type":"text","conversion_output":true,"text":"bound by solid phase streptavidin. After denaturation the hybridization reaction is performed with a","text_display":" bound by solid phase streptavidin. After denaturation the hybridization reaction is performed with a","confidence":1,"confidence_rate":1},{"cnt":[[180,2391],[1944,2391],[1944,2443],[180,2443]],"region":{"top_left_x":180,"top_left_y":2391,"width":1765,"height":52},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ea20b5e3d224e15a1a5f2feea8ff3ef","type":"text","conversion_output":true,"text":"mixture of lanthanide (Europium, Samarium or Terbium) labeled sequence specific oligonucleotide","text_display":" mixture of lanthanide (Europium, Samarium or Terbium) labeled sequence specific oligonucleotide","confidence":1,"confidence_rate":1},{"cnt":[[1899,2582],[1942,2582],[1942,2628],[1899,2628]],"region":{"top_left_x":1899,"top_left_y":2582,"width":44,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7a4bdbf878d45afa05b84bba58af163","type":"page_info","conversion_output":false,"text":"13","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-15","page":15,"lines":[{"cnt":[[786,150],[1296,150],[1296,200],[786,200]],"region":{"top_left_x":786,"top_left_y":150,"width":510,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b41948889214a5480475a17733ad767","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,299],[180,299]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00fb7acb54604f6baa89ebcff4a08658","type":"text","conversion_output":true,"text":"probes and specific hybridization signals detected by time-resolved fluorometry after repeated washes","text_display":"\nprobes and specific hybridization signals detected by time-resolved fluorometry after repeated washes","confidence":1,"confidence_rate":1},{"cnt":[[180,296],[892,296],[892,342],[180,342]],"region":{"top_left_x":180,"top_left_y":296,"width":712,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4778825af8684808a52fdfc5d1965c71","type":"text","conversion_output":true,"text":"and the addition of enhancement solution.","text_display":" and the addition of enhancement solution.","confidence":1,"confidence_rate":1},{"cnt":[[176,385],[778,385],[778,449],[176,449]],"region":{"top_left_x":176,"top_left_y":384,"width":602,"height":66},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3000243903d14f13aa129be5cfa18df2","type":"section_header","conversion_output":false,"children_ids":["5cffaf4dca5d42269895a3783f7ae190"],"text":"","text_display":""},{"cnt":[[183,391],[771,391],[771,443],[183,443]],"region":{"top_left_x":182,"top_left_y":391,"width":590,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cffaf4dca5d42269895a3783f7ae190","type":"text","conversion_output":true,"parent_id":"3000243903d14f13aa129be5cfa18df2","text":"Methodology for Autoantibodies","text_display":"\n\n\\section*{Methodology for Autoantibodies}","confidence":1,"confidence_rate":1},{"cnt":[[180,451],[1949,451],[1949,501],[180,501]],"region":{"top_left_x":180,"top_left_y":451,"width":1769,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"202e759db55f49aaa510ef204fc6fa90","type":"text","conversion_output":true,"text":"We will use islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to the 65 kD isoform of","text_display":"\n\nWe will use islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to the 65 kD isoform of","confidence":0.9990234375,"confidence_rate":0.9999915040391533},{"cnt":[[180,501],[1944,501],[1944,552],[180,552]],"region":{"top_left_x":180,"top_left_y":500,"width":1765,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1af91ff2790473fabe793ea4440ca4a","type":"text","conversion_output":true,"text":"glutamic acid decarboxylase (GADA) and antibodies to the protein tyrosine phosphatase related IA-2","text_display":" glutamic acid decarboxylase (GADA) and antibodies to the protein tyrosine phosphatase related IA-2","confidence":1,"confidence_rate":1},{"cnt":[[180,550],[1944,550],[1944,597],[180,597]],"region":{"top_left_x":180,"top_left_y":550,"width":1765,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"970198800dd949b383346bb769800763","type":"text","conversion_output":true,"text":"molecule (IA-2A) as humoral markers of \\(\\beta\\)-cell autoimmunity. All autoantibody analyses will be","text_display":" molecule (IA-2A) as humoral markers of \\(\\beta\\)-cell autoimmunity. All autoantibody analyses will be","confidence":1,"confidence_rate":1},{"cnt":[[180,595],[1944,595],[1944,647],[180,647]],"region":{"top_left_x":180,"top_left_y":595,"width":1765,"height":52},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed889545b3cc4b5c87ffd34cc8d90279","type":"text","conversion_output":true,"text":"performed in the laboratory of Professor M. Knip, University of Helsinki. His laboratory has a long","text_display":" performed in the laboratory of Professor M. Knip, University of Helsinki. His laboratory has a long","confidence":1,"confidence_rate":1},{"cnt":[[180,645],[1944,645],[1944,694],[180,694]],"region":{"top_left_x":180,"top_left_y":644,"width":1765,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90b461ef8e9945b78395203be842391a","type":"text","conversion_output":true,"text":"experience and acknowledged expertise in the analysis of diabetes-associated autoantibodies. The","text_display":" experience and acknowledged expertise in the analysis of diabetes-associated autoantibodies. The","confidence":1,"confidence_rate":1},{"cnt":[[180,692],[1944,692],[1944,741],[180,741]],"region":{"top_left_x":180,"top_left_y":691,"width":1765,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1006ad36d2bf4d0c955eaa2e46a98491","type":"text","conversion_output":true,"text":"laboratory will pay particular attention to quality control procedures of the assays for autoantibodies.","text_display":" laboratory will pay particular attention to quality control procedures of the assays for autoantibodies.","confidence":1,"confidence_rate":1},{"cnt":[[180,739],[1944,739],[1944,788],[180,788]],"region":{"top_left_x":180,"top_left_y":739,"width":1765,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77bf0d7fd8974fecb5fb514603137fb8","type":"text","conversion_output":true,"text":"All samples are bar-coded, and the analyses will be performed on a blinded basis. Samples from the","text_display":" All samples are bar-coded, and the analyses will be performed on a blinded basis. Samples from the","confidence":1,"confidence_rate":1},{"cnt":[[180,786],[1944,786],[1944,838],[180,838]],"region":{"top_left_x":180,"top_left_y":786,"width":1765,"height":52},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11c2ced7dcf740208fd13288b8990851","type":"text","conversion_output":true,"text":"same individual will, however, be stored in such a way that they can be run in the same assay. Samples","text_display":" same individual will, however, be stored in such a way that they can be run in the same assay. Samples","confidence":1,"confidence_rate":1},{"cnt":[[180,834],[1944,834],[1944,887],[180,887]],"region":{"top_left_x":180,"top_left_y":833,"width":1765,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b01c40c7e3f499b8bd2f2e5ed091ddc","type":"text","conversion_output":true,"text":"will be analyzed in the following assay rounds: the first including samples from the baseline visit ( 0","text_display":" will be analyzed in the following assay rounds: the first including samples from the baseline visit ( 0","confidence":1,"confidence_rate":1},{"cnt":[[180,883],[1944,883],[1944,935],[180,935]],"region":{"top_left_x":180,"top_left_y":883,"width":1765,"height":52},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da9006b43fad41c687d27931c1e4ee7f","type":"text","conversion_output":true,"text":"month visit) up to the 2 -year visit, the second from the 3 -year visit to the 6 -year visit, and after the 6 -","text_display":" month visit) up to the 2 -year visit, the second from the 3 -year visit to the 6 -year visit, and after the 6 ","confidence":0.9975595474243164,"confidence_rate":0.999980910843654},{"cnt":[[180,932],[1944,932],[1944,982],[180,982]],"region":{"top_left_x":180,"top_left_y":932,"width":1765,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a11277f492484a8a964b0d590f94978a","type":"text","conversion_output":true,"text":"year visit annually visit by visit. Possible assay drift over time will be monitored by analyzing blindly","text_display":"year visit annually visit by visit. Possible assay drift over time will be monitored by analyzing blindly","confidence":1,"confidence_rate":1},{"cnt":[[180,980],[1944,980],[1944,1029],[180,1029]],"region":{"top_left_x":180,"top_left_y":979,"width":1765,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4eb6b7b79a554426bfae73b1c3ccf150","type":"text","conversion_output":true,"text":"with each assay three standards (low, medium and high antibody levels) once a month. An assay drift","text_display":" with each assay three standards (low, medium and high antibody levels) once a month. An assay drift","confidence":1,"confidence_rate":1},{"cnt":[[180,1027],[1944,1027],[1944,1076],[180,1076]],"region":{"top_left_x":180,"top_left_y":1026,"width":1765,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4027b84e83e41d389f46ba576952416","type":"text","conversion_output":true,"text":"exceeding \\(10 \\%\\) is considered unacceptable. The laboratory has completed a process of collecting","text_display":" exceeding \\(10 \\%\\) is considered unacceptable. The laboratory has completed a process of collecting","confidence":0.9638671875,"confidence_rate":0.9996392634520023},{"cnt":[[180,1074],[1285,1074],[1285,1126],[180,1126]],"region":{"top_left_x":180,"top_left_y":1074,"width":1105,"height":52},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"931b1a8e18d9478f90e5f3f5fc9fd494","type":"text","conversion_output":true,"text":"optimal standards with sufficient volume for a period of 15 years.","text_display":" optimal standards with sufficient volume for a period of 15 years.","confidence":1,"confidence_rate":1},{"cnt":[[180,1171],[1944,1171],[1944,1222],[180,1222]],"region":{"top_left_x":180,"top_left_y":1170,"width":1765,"height":53},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9d013d71e8846d7a501995d8be3a7eb","type":"text","conversion_output":true,"text":"ICA are analyzed with a standard immunofluorescence assay performed on sections of frozen human","text_display":"\n\nICA are analyzed with a standard immunofluorescence assay performed on sections of frozen human","confidence":1,"confidence_rate":1},{"cnt":[[180,1216],[1944,1216],[1944,1270],[180,1270]],"region":{"top_left_x":180,"top_left_y":1216,"width":1765,"height":54},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e942e58ad004b2b9dea77a2b63517c3","type":"text","conversion_output":true,"text":"pancreas from a blood group O donor (13). Fluorescein-conjugated anti-human IgG (Sigma, St Louis,","text_display":" pancreas from a blood group O donor (13). Fluorescein-conjugated anti-human IgG (Sigma, St Louis,","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[180,1265],[1944,1265],[1944,1317],[180,1317]],"region":{"top_left_x":180,"top_left_y":1265,"width":1765,"height":52},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ba396f83999448e88d7675238534499","type":"text","conversion_output":true,"text":"MO, USA) is used to detect ICA. All initially ICA-positive samples are re-tested to confirm antibody","text_display":" MO, USA) is used to detect ICA. All initially ICA-positive samples are re-tested to confirm antibody","confidence":1,"confidence_rate":1},{"cnt":[[180,1315],[1944,1315],[1944,1364],[180,1364]],"region":{"top_left_x":180,"top_left_y":1314,"width":1765,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95bcae123a1247d78ad14ddc29f1c9f9","type":"text","conversion_output":true,"text":"positivity. End-point dilution titers are identified and the results are expressed in Juvenile Diabetes","text_display":" positivity. End-point dilution titers are identified and the results are expressed in Juvenile Diabetes","confidence":1,"confidence_rate":1},{"cnt":[[180,1362],[1949,1362],[1949,1412],[180,1412]],"region":{"top_left_x":180,"top_left_y":1362,"width":1769,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f168b0b50594d578bfff22b76f768c3","type":"text","conversion_output":true,"text":"Foundation (JDF) units relative to an international reference standard (14). The detection and cut-off","text_display":" Foundation (JDF) units relative to an international reference standard (14). The detection and cut-off","confidence":0.9985356330871582,"confidence_rate":0.9999863043914873},{"cnt":[[180,1409],[1944,1409],[1944,1463],[180,1463]],"region":{"top_left_x":180,"top_left_y":1409,"width":1765,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab1501e8ec0a47d5a45ff91757654daa","type":"text","conversion_output":true,"text":"limit is 2.5 JDF units. The sensitivity of this ICA assay was \\(100 \\%\\), the specificity \\(98 \\%\\) the validity \\(98 \\%\\),","text_display":" limit is 2.5 JDF units. The sensitivity of this ICA assay was \\(100 \\%\\), the specificity \\(98 \\%\\) the validity \\(98 \\%\\),","confidence":0.38604062574449927,"confidence_rate":0.9923534759490628},{"cnt":[[180,1457],[1549,1457],[1549,1508],[180,1508]],"region":{"top_left_x":180,"top_left_y":1456,"width":1370,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5fd504c09f354060b2c2e9c8d17158cf","type":"text","conversion_output":true,"text":"and the consistency \\(98 \\%\\) in the most relevant international standardization round.","text_display":" and the consistency \\(98 \\%\\) in the most relevant international standardization round.","confidence":0.99853515625,"confidence_rate":0.9999835291504493},{"cnt":[[180,1551],[1944,1551],[1944,1605],[180,1605]],"region":{"top_left_x":180,"top_left_y":1551,"width":1765,"height":54},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4de584bcb6b4955a7a8914a38f4fe9b","type":"text","conversion_output":true,"text":"IAA are measured with a micro-assay, modified from Williams et al. (15). According to the assay","text_display":"\n\nIAA are measured with a micro-assay, modified from Williams et al. (15). According to the assay","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[180,1603],[1944,1603],[1944,1652],[180,1652]],"region":{"top_left_x":180,"top_left_y":1602,"width":1765,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b2ef2162f83466f8de2b42ba98cdee3","type":"text","conversion_output":true,"text":"protocol endogenous insulin is not removed before the assay. Immune complexes are precipitated with","text_display":" protocol endogenous insulin is not removed before the assay. Immune complexes are precipitated with","confidence":1,"confidence_rate":1},{"cnt":[[180,1650],[1944,1650],[1944,1699],[180,1699]],"region":{"top_left_x":180,"top_left_y":1650,"width":1765,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70df03e8bca04012a24e67121c9c01f5","type":"text","conversion_output":true,"text":"Protein A Sepharose (Pharmacia Biotech, Uppsala, Sweden) after incubation for 72 h of the serum","text_display":" Protein A Sepharose (Pharmacia Biotech, Uppsala, Sweden) after incubation for 72 h of the serum","confidence":1,"confidence_rate":1},{"cnt":[[180,1693],[1944,1693],[1944,1751],[180,1751]],"region":{"top_left_x":180,"top_left_y":1692,"width":1765,"height":59},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc424de663ac48288549eb253459d2d6","type":"text","conversion_output":true,"text":"sample ( \\(5 \\mu l /\\) well) with mono \\({ }^{125} I -\\left( Tyr ^{ A 14}\\right)\\)-labeled human insulin (Amersham, Little Chalfont, Bucks,","text_display":" sample ( \\(5 \\mu l /\\) well) with mono \\({ }^{125} I -\\left( Tyr ^{ A 14}\\right)\\)-labeled human insulin (Amersham, Little Chalfont, Bucks,","confidence":0.45626656499198254,"confidence_rate":0.9943300621606382},{"cnt":[[183,1749],[1944,1749],[1944,1798],[183,1798]],"region":{"top_left_x":182,"top_left_y":1748,"width":1763,"height":51},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47e79e1717844244a38100dbf379e725","type":"text","conversion_output":true,"text":"UK) in the presence or absence of an excess of unlabeled insulin. The volume of the incubation reaction","text_display":" UK) in the presence or absence of an excess of unlabeled insulin. The volume of the incubation reaction","confidence":1,"confidence_rate":1},{"cnt":[[180,1796],[1944,1796],[1944,1846],[180,1846]],"region":{"top_left_x":180,"top_left_y":1796,"width":1765,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09ea1c1492f549c984efd833dca33056","type":"text","conversion_output":true,"text":"is doubled by adding the reaction buffer (TBT; 50 mM Tris, \\(pH 8.0,1 \\%( v / v )\\) Tween 20). After","text_display":" is doubled by adding the reaction buffer (TBT; 50 mM Tris, \\(pH 8.0,1 \\%( v / v )\\) Tween 20). After","confidence":1,"confidence_rate":1},{"cnt":[[180,1843],[1944,1843],[1944,1895],[180,1895]],"region":{"top_left_x":180,"top_left_y":1843,"width":1765,"height":52},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f0ec69c152498493bf2a11a1874b58","type":"text","conversion_output":true,"text":"thorough washing with the reaction buffer the samples are transferred from the deep well plates to","text_display":" thorough washing with the reaction buffer the samples are transferred from the deep well plates to","confidence":1,"confidence_rate":1},{"cnt":[[180,1893],[1944,1893],[1944,1944],[180,1944]],"region":{"top_left_x":180,"top_left_y":1892,"width":1765,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6693f324f18e4893ab5c713979c88775","type":"text","conversion_output":true,"text":"microtiter plates, scintillation liquid is added and the bound activity measured with a liquid scintillation","text_display":" microtiter plates, scintillation liquid is added and the bound activity measured with a liquid scintillation","confidence":1,"confidence_rate":1},{"cnt":[[180,1938],[1944,1938],[1944,1989],[180,1989]],"region":{"top_left_x":180,"top_left_y":1937,"width":1765,"height":53},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d6cf23681ef4ffabaaaed2f9fab91a4","type":"text","conversion_output":true,"text":"counter ( 1450 MicroBeta Trilux; Perkin Elmer Life Sciences Wallac, Turku, Finland). The specific","text_display":" counter ( 1450 MicroBeta Trilux; Perkin Elmer Life Sciences Wallac, Turku, Finland). The specific","confidence":1,"confidence_rate":1},{"cnt":[[180,1987],[1944,1987],[1944,2039],[180,2039]],"region":{"top_left_x":180,"top_left_y":1987,"width":1765,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85c9dd9f5a4a4bf9960918c8a45b67e4","type":"text","conversion_output":true,"text":"binding is expressed in relative units (RU) based on a standard curve run on each plate using the","text_display":" binding is expressed in relative units (RU) based on a standard curve run on each plate using the","confidence":1,"confidence_rate":1},{"cnt":[[180,2037],[1944,2037],[1944,2086],[180,2086]],"region":{"top_left_x":180,"top_left_y":2036,"width":1765,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79331eb0aec74bd8b18b61059d157b3d","type":"text","conversion_output":true,"text":"MultiCalc \\({ }^{\\text {TM }}\\) software program (Perkin Elmer Life Sciences Wallac). The standard curve is constructed","text_display":" MultiCalc \\({ }^{\\text {TM }}\\) software program (Perkin Elmer Life Sciences Wallac). The standard curve is constructed","confidence":0.9882867336273193,"confidence_rate":0.9999018180941849},{"cnt":[[180,2084],[1944,2084],[1944,2133],[180,2133]],"region":{"top_left_x":180,"top_left_y":2083,"width":1765,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2f51715425b443a8b0c9e0dcf7f0440","type":"text","conversion_output":true,"text":"from nine serial dilutions of a serum from a patient with a high IAA titer and a serum of an IAA-","text_display":" from nine serial dilutions of a serum from a patient with a high IAA titer and a serum of an IAA","confidence":0.9951171875,"confidence_rate":0.9999520131869262},{"cnt":[[180,2131],[1944,2131],[1944,2181],[180,2181]],"region":{"top_left_x":180,"top_left_y":2131,"width":1765,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef827a91a7794d91b2209ddd82390bdb","type":"text","conversion_output":true,"text":"negative subject. The negative human serum is considered as the lowest point of the standard curve.","text_display":"negative subject. The negative human serum is considered as the lowest point of the standard curve.","confidence":1,"confidence_rate":1},{"cnt":[[180,2174],[1944,2174],[1944,2228],[180,2228]],"region":{"top_left_x":180,"top_left_y":2174,"width":1765,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb23b633c8e14bc7a7fbdc2cda10fe5d","type":"text","conversion_output":true,"text":"The cut-off limit for IAA positivity is set at the \\(99{ }^{\\text {th }}\\) centile in 371 non-diabetic Finnish subjects.","text_display":" The cut-off limit for IAA positivity is set at the \\(99{ }^{\\text {th }}\\) centile in 371 non-diabetic Finnish subjects.","confidence":0.5998046398162842,"confidence_rate":0.9958862968350025},{"cnt":[[180,2221],[1944,2221],[1944,2279],[180,2279]],"region":{"top_left_x":180,"top_left_y":2221,"width":1765,"height":59},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e371f537ae14d89a119210e83d9adde","type":"text","conversion_output":true,"text":"Samples with an initial IAA level exceeding the \\(95{ }^{\\text {th }}\\) centile are reanalyzed to verify the antibody status.","text_display":" Samples with an initial IAA level exceeding the \\(95{ }^{\\text {th }}\\) centile are reanalyzed to verify the antibody status.","confidence":0.57763671875,"confidence_rate":0.9956538361344585},{"cnt":[[180,2275],[1944,2275],[1944,2327],[180,2327]],"region":{"top_left_x":180,"top_left_y":2275,"width":1765,"height":52},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"768b65ec23db41ff9bd0c4f624b0a3c8","type":"text","conversion_output":true,"text":"The disease sensitivity of this assay was \\(35 \\%\\) and the disease specificity \\(100 \\%\\) based on 140 samples","text_display":" The disease sensitivity of this assay was \\(35 \\%\\) and the disease specificity \\(100 \\%\\) based on 140 samples","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[180,2325],[1106,2325],[1106,2374],[180,2374]],"region":{"top_left_x":180,"top_left_y":2324,"width":927,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4302fb89a80c420580333f6511d2a35e","type":"text","conversion_output":true,"text":"included in the Multiple Autoantibody Workshop (16).","text_display":" included in the Multiple Autoantibody Workshop (16).","confidence":1,"confidence_rate":1},{"cnt":[[1899,2582],[1946,2582],[1946,2623],[1899,2623]],"region":{"top_left_x":1899,"top_left_y":2582,"width":48,"height":42},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd46302b05d34a7e98d199679ff8275c","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-16","page":16,"lines":[{"cnt":[[786,150],[1296,150],[1296,200],[786,200]],"region":{"top_left_x":786,"top_left_y":150,"width":510,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02de4ab9cdaa4f6a8f6fea38596b56a9","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,299],[180,299]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76f358db5c184c658b58faaad7de5250","type":"text","conversion_output":true,"text":"GADA are detected in an immunoprecipitation radioligand assay (17, 18). The recombinant plasmid","text_display":"\n\nGADA are detected in an immunoprecipitation radioligand assay (17, 18). The recombinant plasmid","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[180,294],[1944,294],[1944,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1765,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0419e66e5d6b43f9ba17829e3f79a930","type":"text","conversion_output":true,"text":"pGEM3 encoding the whole 65 kD form of the GAD protein ( 585 amino acids) is propagated in E. coli","text_display":" pGEM3 encoding the whole 65 kD form of the GAD protein ( 585 amino acids) is propagated in E. coli","confidence":0.8056462360545993,"confidence_rate":0.9980549522068425},{"cnt":[[180,339],[1944,339],[1944,393],[180,393]],"region":{"top_left_x":180,"top_left_y":339,"width":1765,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c17905f366514b1cb1323205eb693fe8","type":"text","conversion_output":true,"text":"JM 109 by standard techniques. The GAD65 protein is produced by in vitro transcription and","text_display":" JM 109 by standard techniques. The GAD65 protein is produced by in vitro transcription and","confidence":1,"confidence_rate":1},{"cnt":[[180,387],[1944,387],[1944,440],[180,440]],"region":{"top_left_x":180,"top_left_y":386,"width":1765,"height":55},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28a36e3db7fe411798e389fc35959859","type":"text","conversion_output":true,"text":"translation of the purified plasmid using the TNT Coupled Reticulocyte Lysate System (Promega,","text_display":" translation of the purified plasmid using the TNT Coupled Reticulocyte Lysate System (Promega,","confidence":1,"confidence_rate":1},{"cnt":[[180,430],[1944,430],[1944,490],[180,490]],"region":{"top_left_x":180,"top_left_y":429,"width":1765,"height":61},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abbf2893eed44fdc96ac8f9492a9e666","type":"text","conversion_output":true,"text":"Madison, WI, USA) in the presence of \\({ }^{35} S\\)-methionine (Amersham). Unincorporated \\({ }^{35} S\\)-methionine is","text_display":" Madison, WI, USA) in the presence of \\({ }^{35} S\\)-methionine (Amersham). Unincorporated \\({ }^{35} S\\)-methionine is","confidence":1,"confidence_rate":1},{"cnt":[[180,486],[1944,486],[1944,539],[180,539]],"region":{"top_left_x":180,"top_left_y":485,"width":1765,"height":55},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75bb5529c7514082acce82b0fff40595","type":"text","conversion_output":true,"text":"removed by gel chromatography on NAP-5 columns (Pharmacia Biotech). Sera \\((2 \\mu l )\\) are incubated","text_display":" removed by gel chromatography on NAP-5 columns (Pharmacia Biotech). Sera \\((2 \\mu l )\\) are incubated","confidence":0.8214626312255859,"confidence_rate":0.9980924156299406},{"cnt":[[180,537],[1944,537],[1944,591],[180,591]],"region":{"top_left_x":180,"top_left_y":537,"width":1765,"height":54},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"70ee3f334fcd4ab99ee4c0df01d2e564","type":"text","conversion_output":true,"text":"overnight at \\(+4^{\\circ} C\\) with approximately \\(20,000 cpm\\) human GAD65 in a total volume of \\(50 \\mu l\\) TBST.","text_display":" overnight at \\(+4^{\\circ} C\\) with approximately \\(20,000 cpm\\) human GAD65 in a total volume of \\(50 \\mu l\\) TBST.","confidence":0.5286836398803301,"confidence_rate":0.9947027049127898},{"cnt":[[180,587],[1944,587],[1944,642],[180,642]],"region":{"top_left_x":180,"top_left_y":586,"width":1765,"height":57},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be8ca54e69fa4d599a06f0a63c4d4b86","type":"text","conversion_output":true,"text":"To isolate the immune complexes, \\(10 \\mu l\\) Protein A-Sepharose \\({ }^{\\circledR}\\) CL-4B (Pharmacia Biotech) is added the","text_display":" To isolate the immune complexes, \\(10 \\mu l\\) Protein A-Sepharose \\({ }^{\\circledR}\\) CL-4B (Pharmacia Biotech) is added the","confidence":0.4047392517031051,"confidence_rate":0.9924278709062642},{"cnt":[[180,636],[1944,636],[1944,690],[180,690]],"region":{"top_left_x":180,"top_left_y":635,"width":1765,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d89952619dac47fca523d2266b54592e","type":"text","conversion_output":true,"text":"following day. A scintillation counter is used to count the amount of precipitated immune complexes.","text_display":" following day. A scintillation counter is used to count the amount of precipitated immune complexes.","confidence":1,"confidence_rate":1},{"cnt":[[180,683],[1944,683],[1944,737],[180,737]],"region":{"top_left_x":180,"top_left_y":683,"width":1765,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3484b703ddbd430083a192b4af59daad","type":"text","conversion_output":true,"text":"The results are expressed in relative units (RU) based on a standard curve run on each plate using a","text_display":" The results are expressed in relative units (RU) based on a standard curve run on each plate using a","confidence":1,"confidence_rate":1},{"cnt":[[180,730],[1946,730],[1946,784],[180,784]],"region":{"top_left_x":180,"top_left_y":730,"width":1767,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c34f1780e4344b2e9c3c3a78b36029f6","type":"text","conversion_output":true,"text":"commercial software program (MultiCalc \\({ }^{ TM }\\), Perkin Elmer Life Sciences Wallac). The cut-off limit for","text_display":" commercial software program (MultiCalc \\({ }^{ TM }\\), Perkin Elmer Life Sciences Wallac). The cut-off limit for","confidence":0.8438987731933594,"confidence_rate":0.9985747751825071},{"cnt":[[180,773],[1944,773],[1944,831],[180,831]],"region":{"top_left_x":180,"top_left_y":773,"width":1765,"height":59},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9738b8f35ac46b0af07c8e55fbcfa6e","type":"text","conversion_output":true,"text":"antibody positivity is set at the \\(99{ }^{\\text {th }}\\) percentile in 373 non-diabetic children and adolescents. All samples","text_display":" antibody positivity is set at the \\(99{ }^{\\text {th }}\\) percentile in 373 non-diabetic children and adolescents. All samples","confidence":0.85205078125,"confidence_rate":0.9987691492610539},{"cnt":[[180,821],[1944,821],[1944,881],[180,881]],"region":{"top_left_x":180,"top_left_y":820,"width":1765,"height":61},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05787e24efe74dd594bd00de6636d7d9","type":"text","conversion_output":true,"text":"with an initial GADA level between the \\(97.5^{\\text {th }}\\) and \\(99.5^{\\text {th }}\\) percentiles are reanalyzed to verify the","text_display":" with an initial GADA level between the \\(97.5^{\\text {th }}\\) and \\(99.5^{\\text {th }}\\) percentiles are reanalyzed to verify the","confidence":1,"confidence_rate":1},{"cnt":[[180,872],[1944,872],[1944,930],[180,930]],"region":{"top_left_x":180,"top_left_y":872,"width":1765,"height":59},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b3210e826d1427ab507f281f27039e7","type":"text","conversion_output":true,"text":"antibody status. This assay had a disease sensitivity of \\(69 \\%\\) and a specificity of \\(100 \\%\\) based on 140","text_display":" antibody status. This assay had a disease sensitivity of \\(69 \\%\\) and a specificity of \\(100 \\%\\) based on 140","confidence":0.9873163672164083,"confidence_rate":0.999882898996782},{"cnt":[[180,924],[1347,924],[1347,978],[180,978]],"region":{"top_left_x":180,"top_left_y":923,"width":1168,"height":55},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3f31a4e5783474aa0c3031554ff415b","type":"text","conversion_output":true,"text":"samples included in the 1995 Multiple Autoantibody Workshop (16).","text_display":" samples included in the 1995 Multiple Autoantibody Workshop (16).","confidence":1,"confidence_rate":1},{"cnt":[[180,1018],[1944,1018],[1944,1072],[180,1072]],"region":{"top_left_x":180,"top_left_y":1018,"width":1765,"height":55},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3c4ccc2714b491c839ca02c04f82133","type":"text","conversion_output":true,"text":"IA-2A are detected in a similar radiobinding assay (19). The recombinant plasmid pSP64poly(A)","text_display":"\n\nIA-2A are detected in a similar radiobinding assay (19). The recombinant plasmid pSP64poly(A)","confidence":0.8728043135488406,"confidence_rate":0.9986127600237045},{"cnt":[[180,1066],[1944,1066],[1944,1121],[180,1121]],"region":{"top_left_x":180,"top_left_y":1065,"width":1765,"height":57},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a37cc9a51a5f4cfc8148d87f711fe5bc","type":"text","conversion_output":true,"text":"encoding the intracellular portion of the full length IA-2 protein, including amino acids 605-979 is","text_display":" encoding the intracellular portion of the full length IA-2 protein, including amino acids 605-979 is","confidence":1,"confidence_rate":1},{"cnt":[[180,1113],[1944,1113],[1944,1171],[180,1171]],"region":{"top_left_x":180,"top_left_y":1112,"width":1765,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2493205da43b420197d79fb00fe82a08","type":"text","conversion_output":true,"text":"propagated in E. coli JM 109 cells. The radioactive IA-2 protein is produced with the TNT Coupled","text_display":" propagated in E. coli JM 109 cells. The radioactive IA-2 protein is produced with the TNT Coupled","confidence":1,"confidence_rate":1},{"cnt":[[180,1162],[1944,1162],[1944,1216],[180,1216]],"region":{"top_left_x":180,"top_left_y":1162,"width":1765,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96fc25f1412a4abf8677a67547069657","type":"text","conversion_output":true,"text":"Reticulocyte Lysate System (Promega) by in vitro transcription and translation of the purified plasmid in","text_display":" Reticulocyte Lysate System (Promega) by in vitro transcription and translation of the purified plasmid in","confidence":1,"confidence_rate":1},{"cnt":[[180,1203],[1944,1203],[1944,1263],[180,1263]],"region":{"top_left_x":180,"top_left_y":1203,"width":1765,"height":61},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a9596f3502347aaba0c5b606531ad07","type":"text","conversion_output":true,"text":"the presence of \\({ }^{35} S\\)-methionine. Sera are incubated overnight at \\(+4{ }^{\\circ} C\\) with \\(10,000 cpm\\) of labeled IA-2","text_display":" the presence of \\({ }^{35} S\\)-methionine. Sera are incubated overnight at \\(+4{ }^{\\circ} C\\) with \\(10,000 cpm\\) of labeled IA-2","confidence":0.9990236759185791,"confidence_rate":0.9999928700911389},{"cnt":[[180,1257],[1944,1257],[1944,1313],[180,1313]],"region":{"top_left_x":180,"top_left_y":1256,"width":1765,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8916350f89a946d2bd56e76109f34547","type":"text","conversion_output":true,"text":"protein. Protein-A Sepharose \\({ }^{\\circledR}\\) (Pharmacia Biotech) is used to isolate the immune complexes on the","text_display":" protein. Protein-A Sepharose \\({ }^{\\circledR}\\) (Pharmacia Biotech) is used to isolate the immune complexes on the","confidence":0.6992497037408612,"confidence_rate":0.9968109229915838},{"cnt":[[180,1306],[1944,1306],[1944,1360],[180,1360]],"region":{"top_left_x":180,"top_left_y":1306,"width":1765,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18f3d0e1b57b4b839dfffde457a14866","type":"text","conversion_output":true,"text":"following day. After thorough washing the radioactivity of the samples is measured by a liquid","text_display":" following day. After thorough washing the radioactivity of the samples is measured by a liquid","confidence":0.9990234375,"confidence_rate":0.9999901309613475},{"cnt":[[180,1354],[1944,1354],[1944,1407],[180,1407]],"region":{"top_left_x":180,"top_left_y":1353,"width":1765,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"985895bf7b7343b1a67d6b1d807403d6","type":"text","conversion_output":true,"text":"scintillation counter ( 1450 Microbeta \\({ }^{\\circledR}\\) Trilux, Perkin Elmer Life Sciences Wallac). The results are","text_display":" scintillation counter ( 1450 Microbeta \\({ }^{\\circledR}\\) Trilux, Perkin Elmer Life Sciences Wallac). The results are","confidence":0.6669132541810875,"confidence_rate":0.9965728750681478},{"cnt":[[180,1401],[1944,1401],[1944,1454],[180,1454]],"region":{"top_left_x":180,"top_left_y":1400,"width":1765,"height":55},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17c659f4ec3b45a6b1ef53ac1e1387f9","type":"text","conversion_output":true,"text":"expressed in RU based on a standard curve constructed from the dilution of a pool of strongly positive","text_display":" expressed in RU based on a standard curve constructed from the dilution of a pool of strongly positive","confidence":1,"confidence_rate":1},{"cnt":[[180,1448],[1944,1448],[1944,1504],[180,1504]],"region":{"top_left_x":180,"top_left_y":1448,"width":1765,"height":56},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87ae872613c14940aa7056155aaee6a1","type":"text","conversion_output":true,"text":"samples and a pool of negative samples. The standard curve is run on each plate. A subject is","text_display":" samples and a pool of negative samples. The standard curve is run on each plate. A subject is","confidence":1,"confidence_rate":1},{"cnt":[[180,1491],[1944,1491],[1944,1551],[180,1551]],"region":{"top_left_x":180,"top_left_y":1491,"width":1765,"height":61},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5048a90cfa764687b75fb14b3fc54b10","type":"text","conversion_output":true,"text":"considered IA-2A positive, if the serum antibody levels are equal to or exceed the \\(99^{\\text {th }}\\) percentile in 374","text_display":" considered IA-2A positive, if the serum antibody levels are equal to or exceed the \\(99^{\\text {th }}\\) percentile in 374","confidence":0.9546117782592773,"confidence_rate":0.9996254690569506},{"cnt":[[180,1538],[1946,1538],[1946,1601],[180,1601]],"region":{"top_left_x":180,"top_left_y":1538,"width":1767,"height":63},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf20b030f29c40a59cb2d2d5aad55066","type":"text","conversion_output":true,"text":"non-diabetic Finnish children and adolescents. Samples with an initial IA-2A level between the \\(97.5^{\\text {th }}\\)","text_display":" non-diabetic Finnish children and adolescents. Samples with an initial IA-2A level between the \\(97.5^{\\text {th }}\\)","confidence":0.9355781078338623,"confidence_rate":0.9994310111354918},{"cnt":[[180,1588],[1944,1588],[1944,1648],[180,1648]],"region":{"top_left_x":180,"top_left_y":1587,"width":1765,"height":61},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fd575567308433c8d18db3ea6b0e5d3","type":"text","conversion_output":true,"text":"and \\(99.5^{\\text {th }}\\) percentiles are reanalyzed to verify the antibody status. The disease sensitivity of this assay","text_display":" and \\(99.5^{\\text {th }}\\) percentiles are reanalyzed to verify the antibody status. The disease sensitivity of this assay","confidence":0.99951171875,"confidence_rate":0.999996123813083},{"cnt":[[180,1641],[1944,1641],[1944,1695],[180,1695]],"region":{"top_left_x":180,"top_left_y":1641,"width":1765,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"057da7aa41824d5c809892f8fecdc48e","type":"text","conversion_output":true,"text":"was \\(62 \\%\\) and the specificity \\(97 \\%\\) based on 140 samples included in the 1995 Multiple Autoantibody","text_display":" was \\(62 \\%\\) and the specificity \\(97 \\%\\) based on 140 samples included in the 1995 Multiple Autoantibody","confidence":0.9975595474243164,"confidence_rate":0.9999781838510657},{"cnt":[[180,1689],[455,1689],[455,1742],[180,1742]],"region":{"top_left_x":180,"top_left_y":1688,"width":276,"height":55},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae2345cc28b042be9420835a1b83dfdd","type":"text","conversion_output":true,"text":"Workshop (16).","text_display":" Workshop (16).","confidence":1,"confidence_rate":1},{"cnt":[[176,1779],[1119,1779],[1119,1846],[176,1846]],"region":{"top_left_x":176,"top_left_y":1778,"width":944,"height":68},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f02333a4d324eeead5ceb2f677fcc4f","type":"section_header","conversion_output":false,"children_ids":["758bb7f14cdc424b938c5d6bc0774d7b"],"text":"","text_display":""},{"cnt":[[183,1788],[1113,1788],[1113,1841],[183,1841]],"region":{"top_left_x":182,"top_left_y":1787,"width":931,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"758bb7f14cdc424b938c5d6bc0774d7b","type":"text","conversion_output":true,"parent_id":"3f02333a4d324eeead5ceb2f677fcc4f","text":"Methodology for Antibodies to Cow's Milk Proteins","text_display":"\n\n\\section*{Methodology for Antibodies to Cow's Milk Proteins}","confidence":1,"confidence_rate":1},{"cnt":[[180,1852],[1944,1852],[1944,1904],[180,1904]],"region":{"top_left_x":180,"top_left_y":1851,"width":1765,"height":53},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f76bfac19bdc4afb94d613c561b5dd91","type":"text","conversion_output":true,"text":"CM antibodies ( \\(\\operatorname{IgG}\\), \\(\\operatorname{IgA}\\) and \\(\\operatorname{IgM}\\) ), \\(\\beta\\)-lactoglobulin antibodies ( \\(\\operatorname{IgG}\\) and \\(\\operatorname{IgA}\\) ), \\(\\alpha\\)-casein antibodies ( \\(\\operatorname{IgG}\\)","text_display":"\n\nCM antibodies ( \\(\\operatorname{IgG}\\), \\(\\operatorname{IgA}\\) and \\(\\operatorname{IgM}\\) ), \\(\\beta\\)-lactoglobulin antibodies ( \\(\\operatorname{IgG}\\) and \\(\\operatorname{IgA}\\) ), \\(\\alpha\\)-casein antibodies ( \\(\\operatorname{IgG}\\)","confidence":0.673927827039067,"confidence_rate":0.9973899534652392},{"cnt":[[180,1899],[1944,1899],[1944,1951],[180,1951]],"region":{"top_left_x":180,"top_left_y":1899,"width":1765,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"057202cf577d4c0ab5c900aa4d5d6df0","type":"text","conversion_output":true,"text":"and \\(\\operatorname{Ig} A\\) ) and BSA antibodies ( \\(\\operatorname{IgG}\\) and \\(\\operatorname{IgA}\\) ) will be measured with a modification of the original ELISA","text_display":" and \\(\\operatorname{Ig} A\\) ) and BSA antibodies ( \\(\\operatorname{IgG}\\) and \\(\\operatorname{IgA}\\) ) will be measured with a modification of the original ELISA","confidence":0.9863999423222524,"confidence_rate":0.9998938553577336},{"cnt":[[180,1946],[999,1946],[999,2000],[180,2000]],"region":{"top_left_x":180,"top_left_y":1946,"width":820,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a77c4648380f447e8a472d987859d0b2","type":"text","conversion_output":true,"text":"technique by Dr. E. Savilahti, Helsinki, Finland.","text_display":" technique by Dr. E. Savilahti, Helsinki, Finland.","confidence":1,"confidence_rate":1},{"cnt":[[180,2041],[1944,2041],[1944,2095],[180,2095]],"region":{"top_left_x":180,"top_left_y":2041,"width":1765,"height":54},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"607efa077da94ce4851b1ad6cc30fc10","type":"text","conversion_output":true,"text":"Microtitre plates (MaxiSorp \\({ }^{\\circledR}\\), Nunc A/S, Roskilde, Denmark) are coated with one of the following","text_display":"\n\nMicrotitre plates (MaxiSorp \\({ }^{\\circledR}\\), Nunc A/S, Roskilde, Denmark) are coated with one of the following","confidence":0.6945425982256782,"confidence_rate":0.9967508098827061},{"cnt":[[180,2088],[1944,2088],[1944,2142],[180,2142]],"region":{"top_left_x":180,"top_left_y":2088,"width":1765,"height":54},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"994a511f045d4302a4f88e2f2b0b1196","type":"text","conversion_output":true,"text":"antigens: 1. adapted liquid CM formula (Tutteli®, Valio Ltd, Helsinki, Finland) defatted, diluted (1:500","text_display":" antigens: 1. adapted liquid CM formula (Tutteli®, Valio Ltd, Helsinki, Finland) defatted, diluted (1:500","confidence":0.60888671875,"confidence_rate":0.9954587552492081},{"cnt":[[180,2138],[1944,2138],[1944,2191],[180,2191]],"region":{"top_left_x":180,"top_left_y":2137,"width":1765,"height":55},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c25f7ccb9c24a59b5d02a67d495974b","type":"text","conversion_output":true,"text":"in carbonate buffer, pH 9.6 ) bovernight, 2. bovine \\(\\beta\\)-lactoglobulin (Sigma Pharmaceuticals, St. Louis,","text_display":" in carbonate buffer, pH 9.6 ) bovernight, 2. bovine \\(\\beta\\)-lactoglobulin (Sigma Pharmaceuticals, St. Louis,","confidence":0.9902631992008537,"confidence_rate":0.9999156543037743},{"cnt":[[180,2187],[1944,2187],[1944,2241],[180,2241]],"region":{"top_left_x":180,"top_left_y":2187,"width":1765,"height":54},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0088e9c49e1e406db5189f81880edf3a","type":"text","conversion_output":true,"text":"MO, USA), at a concentration of \\(1 mg / ml\\) in carbonate buffer, pH 9.6 , overnight, 3 . BSA ( \\(2 mg / ml\\),","text_display":" MO, USA), at a concentration of \\(1 mg / ml\\) in carbonate buffer, pH 9.6 , overnight, 3 . BSA ( \\(2 mg / ml\\),","confidence":1,"confidence_rate":1},{"cnt":[[180,2237],[1944,2237],[1944,2292],[180,2292]],"region":{"top_left_x":180,"top_left_y":2236,"width":1765,"height":57},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ac2c43b856e43398e609db3e17a0ddf","type":"text","conversion_output":true,"text":"grade V, Sigma), 4. \\(\\alpha\\)-casein (Sigma) \\(2 mg / ml\\) in phosphate buffered saline (PBS), pH 7.4 . Thereafter","text_display":" grade V, Sigma), 4. \\(\\alpha\\)-casein (Sigma) \\(2 mg / ml\\) in phosphate buffered saline (PBS), pH 7.4 . Thereafter","confidence":0.9712052345275879,"confidence_rate":0.9997605412245109},{"cnt":[[180,2286],[1944,2286],[1944,2340],[180,2340]],"region":{"top_left_x":180,"top_left_y":2285,"width":1765,"height":55},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fad6b4b6d5f4c3e98c54e66827acca8","type":"text","conversion_output":true,"text":"they are incubated overnight. Wells are blocked either with \\(0.5 \\%\\) sheep serum (for anti-CM and \\(\\beta\\) -","text_display":" they are incubated overnight. Wells are blocked either with \\(0.5 \\%\\) sheep serum (for anti-CM and \\(\\beta\\) ","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[180,2333],[1944,2333],[1944,2391],[180,2391]],"region":{"top_left_x":180,"top_left_y":2333,"width":1765,"height":59},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49f3a104553b43d7ab7b5727e23f68b5","type":"text","conversion_output":true,"text":"lactoglobulin assays) or with \\(1 \\%\\) gelatin in PBS pH 7.4 (for BSA and \\(\\alpha\\)-casein assays). Serum samples","text_display":"lactoglobulin assays) or with \\(1 \\%\\) gelatin in PBS pH 7.4 (for BSA and \\(\\alpha\\)-casein assays). Serum samples","confidence":0.8620582878372774,"confidence_rate":0.9987212287454647},{"cnt":[[180,2385],[1944,2385],[1944,2443],[180,2443]],"region":{"top_left_x":180,"top_left_y":2384,"width":1765,"height":59},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28ff30463fab49918d31fa478852849f","type":"text","conversion_output":true,"text":"are diluted in the blocking buffers. Triplicate dilutions for assays are 1:20 for \\(\\beta\\)-lactoglobulin, 1:40 for","text_display":" are diluted in the blocking buffers. Triplicate dilutions for assays are 1:20 for \\(\\beta\\)-lactoglobulin, 1:40 for","confidence":0.9810342788696289,"confidence_rate":0.999834945715675},{"cnt":[[180,2436],[1944,2436],[1944,2494],[180,2494]],"region":{"top_left_x":180,"top_left_y":2436,"width":1765,"height":59},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfe8ad54650d4eb4a21b378c9936ad92","type":"text","conversion_output":true,"text":"CM and BSA and 1:100 for \\(\\alpha\\)-casein. In assays for CM and \\(\\beta\\)-lactoglobulin antibodies, plates are","text_display":" CM and BSA and 1:100 for \\(\\alpha\\)-casein. In assays for CM and \\(\\beta\\)-lactoglobulin antibodies, plates are","confidence":0.776574501216146,"confidence_rate":0.997639587398083},{"cnt":[[1899,2582],[1946,2582],[1946,2625],[1899,2625]],"region":{"top_left_x":1899,"top_left_y":2582,"width":48,"height":44},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6e6c973932eb4b36b6ee20751b774ecd","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-17","page":17,"lines":[{"cnt":[[786,150],[1293,150],[1293,200],[786,200]],"region":{"top_left_x":786,"top_left_y":150,"width":508,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d50d43d4c96a4347b690c335dc5567a6","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,249],[1944,249],[1944,299],[180,299]],"region":{"top_left_x":180,"top_left_y":249,"width":1765,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2140eb671f1649d3869187ed8828bdaf","type":"text","conversion_output":true,"text":"incubated with serum dilutions overnight at room temperature, in assays for BSA and \\(\\alpha\\)-casein at \\(37^{\\circ} C\\)","text_display":"\nincubated with serum dilutions overnight at room temperature, in assays for BSA and \\(\\alpha\\)-casein at \\(37^{\\circ} C\\)","confidence":0.9970703125,"confidence_rate":0.9999751360088194},{"cnt":[[180,301],[1944,301],[1944,350],[180,350]],"region":{"top_left_x":180,"top_left_y":300,"width":1765,"height":51},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40fa5ef27de74dcc9226b79d84221f69","type":"text","conversion_output":true,"text":"for 1 hour. After washing, \\(100 \\mu l\\) alkaline-phosphatase-conjugated affinity purified rabbit \\(F \\left( ab ^{\\prime}\\right)_{2}\\) anti-","text_display":" for 1 hour. After washing, \\(100 \\mu l\\) alkaline-phosphatase-conjugated affinity purified rabbit \\(F \\left( ab ^{\\prime}\\right)_{2}\\) anti","confidence":0.7652511596679688,"confidence_rate":0.9980907450522675},{"cnt":[[180,348],[1944,348],[1944,400],[180,400]],"region":{"top_left_x":180,"top_left_y":348,"width":1765,"height":52},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f232d01231f4aa882f5677ea3f8ec9c","type":"text","conversion_output":true,"text":"human \\(\\operatorname{IgG}, \\operatorname{IgA}\\) or \\(\\operatorname{IgM}\\) antisera (dilutions between 1:600 to \\(1: 1200\\) ) (Dako A/S, Glostrup, Denmark)","text_display":"human \\(\\operatorname{IgG}, \\operatorname{IgA}\\) or \\(\\operatorname{IgM}\\) antisera (dilutions between 1:600 to \\(1: 1200\\) ) (Dako A/S, Glostrup, Denmark)","confidence":0.1156742302175479,"confidence_rate":0.9820374248633584},{"cnt":[[180,400],[1944,400],[1944,449],[180,449]],"region":{"top_left_x":180,"top_left_y":399,"width":1765,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"808cd62ad0f04101b65a130fd52c542f","type":"text","conversion_output":true,"text":"are added for 60 minutes at \\(37^{\\circ} C\\). After washing, \\(100 \\mu l\\) of p-nitrophenyl-phosphate substrate, 2","text_display":" are added for 60 minutes at \\(37^{\\circ} C\\). After washing, \\(100 \\mu l\\) of p-nitrophenyl-phosphate substrate, 2","confidence":0.9951193332672119,"confidence_rate":0.9999595659738156},{"cnt":[[180,449],[1944,449],[1944,501],[180,501]],"region":{"top_left_x":180,"top_left_y":449,"width":1765,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"398fde09c3714755b1061bd6b0a1090e","type":"text","conversion_output":true,"text":"\\(mg / ml\\) in diethanolamine buffer, pH 10.0 , (Medix Biochemica, Helsinki, Finland) is added. The","text_display":" \\(mg / ml\\) in diethanolamine buffer, pH 10.0 , (Medix Biochemica, Helsinki, Finland) is added. The","confidence":0.9980478286743164,"confidence_rate":0.9999819068368716},{"cnt":[[180,498],[1944,498],[1944,548],[180,548]],"region":{"top_left_x":180,"top_left_y":498,"width":1765,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecc6223eea424595baf35c437fe9f671","type":"text","conversion_output":true,"text":"reaction is stopped after 30 minutes with \\(100 \\mu l 1 M NaOH\\). The end point measure of OD405 nm is","text_display":" reaction is stopped after 30 minutes with \\(100 \\mu l 1 M NaOH\\). The end point measure of OD405 nm is","confidence":0.9054799539735541,"confidence_rate":0.9990977696186419},{"cnt":[[180,546],[1944,546],[1944,597],[180,597]],"region":{"top_left_x":180,"top_left_y":545,"width":1765,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"058e20a38ad2492cb8436273f9a1eaed","type":"text","conversion_output":true,"text":"obtained in a semi-automatic multiwell photometer (Titertek Multiscan®, Elflab Inc., Helsinki, Finland).","text_display":" obtained in a semi-automatic multiwell photometer (Titertek Multiscan®, Elflab Inc., Helsinki, Finland).","confidence":0.9736328125,"confidence_rate":0.9997548829301576},{"cnt":[[180,593],[1944,593],[1944,645],[180,645]],"region":{"top_left_x":180,"top_left_y":592,"width":1765,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3af556f66b204464b7353176781c5b38","type":"text","conversion_output":true,"text":"The mean value of two absorbances for wells coated with blocking solution is subtracted from the mean","text_display":" The mean value of two absorbances for wells coated with blocking solution is subtracted from the mean","confidence":1,"confidence_rate":1},{"cnt":[[180,642],[1944,642],[1944,694],[180,694]],"region":{"top_left_x":180,"top_left_y":642,"width":1765,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64fce3a32d8847c6a30180e43e603a5a","type":"text","conversion_output":true,"text":"value for the three absorbances in antigen-coated wells. Results are subjected to point-to-point analysis","text_display":" value for the three absorbances in antigen-coated wells. Results are subjected to point-to-point analysis","confidence":1,"confidence_rate":1},{"cnt":[[180,692],[1944,692],[1944,741],[180,741]],"region":{"top_left_x":180,"top_left_y":691,"width":1765,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38b11531c27c4a7aad26697f62b33398","type":"text","conversion_output":true,"text":"in a computerized photometer using 2-fold serial dilutions of a high titer standard serum as reference.","text_display":" in a computerized photometer using 2-fold serial dilutions of a high titer standard serum as reference.","confidence":0.50390625,"confidence_rate":0.9936741205643845},{"cnt":[[180,739],[1944,739],[1944,788],[180,788]],"region":{"top_left_x":180,"top_left_y":739,"width":1765,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fed96543eca94af7b49d2ad5c3bbe004","type":"text","conversion_output":true,"text":"Sample dilutions must fall within the linear part of the standard curve, and antibody levels are expressed","text_display":" Sample dilutions must fall within the linear part of the standard curve, and antibody levels are expressed","confidence":0.998046875,"confidence_rate":0.999982387228658},{"cnt":[[180,786],[703,786],[703,836],[180,836]],"region":{"top_left_x":180,"top_left_y":786,"width":523,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc65244b066b4e97876276a024895b1a","type":"text","conversion_output":true,"text":"as percentages of the standard.","text_display":" as percentages of the standard.","confidence":0.9990234375,"confidence_rate":0.9999728603780688},{"cnt":[[816,915],[1304,915],[1304,971],[816,971]],"region":{"top_left_x":816,"top_left_y":915,"width":489,"height":57},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7599d8603f534f67a44b7c6c17026476","type":"section_header","conversion_output":false,"children_ids":["1cec404e72e444b5bc832e262f0bd676"],"text":"","text_display":""},{"cnt":[[821,920],[1298,920],[1298,965],[821,965]],"region":{"top_left_x":820,"top_left_y":919,"width":478,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cec404e72e444b5bc832e262f0bd676","type":"text","conversion_output":true,"parent_id":"7599d8603f534f67a44b7c6c17026476","text":"J. CONTAMINATION","text_display":"\n\n\\section*{J. CONTAMINATION}","confidence":1,"confidence_rate":1},{"cnt":[[180,1010],[1944,1010],[1944,1061],[180,1061]],"region":{"top_left_x":180,"top_left_y":1009,"width":1765,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce5c0fd0db7c481690a41a0ca4ef3edc","type":"text","conversion_output":true,"text":"It is critical to ensure that subjects who are randomized to receive the intervention formula, are not","text_display":"\n\nIt is critical to ensure that subjects who are randomized to receive the intervention formula, are not","confidence":1,"confidence_rate":1},{"cnt":[[180,1059],[1944,1059],[1944,1111],[180,1111]],"region":{"top_left_x":180,"top_left_y":1059,"width":1765,"height":52},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e554fc7a2894446aa91f61b73d4e301e","type":"text","conversion_output":true,"text":"exposed to CM protein during the intervention period. The risk is especially high in the immediate","text_display":" exposed to CM protein during the intervention period. The risk is especially high in the immediate","confidence":1,"confidence_rate":1},{"cnt":[[180,1106],[1944,1106],[1944,1158],[180,1158]],"region":{"top_left_x":180,"top_left_y":1106,"width":1765,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52ede90960f645b59a2c7447e4aecd63","type":"text","conversion_output":true,"text":"postpartum period when a newborn infant may be given the wrong formula for supplementation in the","text_display":" postpartum period when a newborn infant may be given the wrong formula for supplementation in the","confidence":1,"confidence_rate":1},{"cnt":[[180,1156],[1944,1156],[1944,1205],[180,1205]],"region":{"top_left_x":180,"top_left_y":1155,"width":1765,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd888129a41d4cdb851c5912653cf316","type":"text","conversion_output":true,"text":"hospital nursery. To prevent such contamination, infants who are in the study are clearly identified to all","text_display":" hospital nursery. To prevent such contamination, infants who are in the study are clearly identified to all","confidence":1,"confidence_rate":1},{"cnt":[[180,1203],[1944,1203],[1944,1253],[180,1253]],"region":{"top_left_x":180,"top_left_y":1203,"width":1765,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ecd6fb536ecc49a4b6cfb675604fa15b","type":"text","conversion_output":true,"text":"nursery personnel. Any formula supplementation for these infants is only with Nutramigen if formula is","text_display":" nursery personnel. Any formula supplementation for these infants is only with Nutramigen if formula is","confidence":1,"confidence_rate":1},{"cnt":[[180,1250],[1027,1250],[1027,1302],[180,1302]],"region":{"top_left_x":180,"top_left_y":1250,"width":847,"height":52},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6cb611292d2473ca47a4671fae2df18","type":"text","conversion_output":true,"text":"required prior to randomization (interim formula).","text_display":" required prior to randomization (interim formula).","confidence":1,"confidence_rate":1},{"cnt":[[885,1379],[1235,1379],[1235,1435],[885,1435]],"region":{"top_left_x":885,"top_left_y":1379,"width":351,"height":57},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30d97fb3b235487197ef985950c343f4","type":"section_header","conversion_output":false,"children_ids":["f0b0fa1f9d474464beee3b9c84c384b4"],"text":"","text_display":""},{"cnt":[[889,1384],[1229,1384],[1229,1429],[889,1429]],"region":{"top_left_x":889,"top_left_y":1383,"width":340,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0b0fa1f9d474464beee3b9c84c384b4","type":"text","conversion_output":true,"parent_id":"30d97fb3b235487197ef985950c343f4","text":"K. DATA BASE","text_display":"\n\n\\section*{K. DATA BASE}","confidence":1,"confidence_rate":1},{"cnt":[[180,1491],[1944,1491],[1944,1540],[180,1540]],"region":{"top_left_x":180,"top_left_y":1491,"width":1765,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9078a4f81b294404b0b5e9f487fd7466","type":"text","conversion_output":true,"text":"The database is held at the Pediatrics Epidemiology Center at the University of South Florida, Tampa,","text_display":"\n\nThe database is held at the Pediatrics Epidemiology Center at the University of South Florida, Tampa,","confidence":1,"confidence_rate":1},{"cnt":[[180,1538],[1944,1538],[1944,1588],[180,1588]],"region":{"top_left_x":180,"top_left_y":1538,"width":1765,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dcc75160e011403fa5cc09728a0b1329","type":"text","conversion_output":true,"text":"FL, headed by Professor Jeffrey Krischer. The web sites were built by the DMU in Tampa with the","text_display":" FL, headed by Professor Jeffrey Krischer. The web sites were built by the DMU in Tampa with the","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[183,1586],[1944,1586],[1944,1635],[183,1635]],"region":{"top_left_x":182,"top_left_y":1585,"width":1763,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"438510a9920d4a5f8a56946bc07f1f69","type":"text","conversion_output":true,"text":"assistance of the TRIGR International Coordination Center in Helsinki. The DMU has established the","text_display":" assistance of the TRIGR International Coordination Center in Helsinki. The DMU has established the","confidence":1,"confidence_rate":1},{"cnt":[[183,1633],[1944,1633],[1944,1687],[183,1687]],"region":{"top_left_x":182,"top_left_y":1632,"width":1763,"height":55},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82d4bd331dad44d1b18ea6843aba3acc","type":"text","conversion_output":true,"text":"data transfer system between the laboratories and the database using File Transfer Protocol (FTP)","text_display":" data transfer system between the laboratories and the database using File Transfer Protocol (FTP)","confidence":1,"confidence_rate":1},{"cnt":[[180,1680],[1944,1680],[1944,1734],[180,1734]],"region":{"top_left_x":180,"top_left_y":1680,"width":1765,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22671d5340ab4034b2645c6d724aba28","type":"text","conversion_output":true,"text":"technique. The system has recently been tested. The DMU created a password-based security","text_display":" technique. The system has recently been tested. The DMU created a password-based security","confidence":1,"confidence_rate":1},{"cnt":[[180,1729],[1944,1729],[1944,1781],[180,1781]],"region":{"top_left_x":180,"top_left_y":1729,"width":1765,"height":53},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67e5155aeed04d4f9a4f85e7b4eb7e9d","type":"text","conversion_output":true,"text":"management system for all the users who are authorized in the system and the user information was","text_display":" management system for all the users who are authorized in the system and the user information was","confidence":1,"confidence_rate":1},{"cnt":[[180,1779],[758,1779],[758,1828],[180,1828]],"region":{"top_left_x":180,"top_left_y":1778,"width":579,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c776319b4ec4034aac3076def1bddfd","type":"text","conversion_output":true,"text":"collected and saved in the system.","text_display":" collected and saved in the system.","confidence":1,"confidence_rate":1},{"cnt":[[735,1910],[1384,1910],[1384,1966],[735,1966]],"region":{"top_left_x":734,"top_left_y":1909,"width":650,"height":57},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"790af64a7d834373a170e724b784c1f0","type":"section_header","conversion_output":false,"children_ids":["bfeb41159768461bb2a3967b2dad39a4"],"text":"","text_display":""},{"cnt":[[743,1916],[1377,1916],[1377,1962],[743,1962]],"region":{"top_left_x":743,"top_left_y":1916,"width":635,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfeb41159768461bb2a3967b2dad39a4","type":"text","conversion_output":true,"parent_id":"790af64a7d834373a170e724b784c1f0","text":"L. STATISTICAL METHODS","text_display":"\n\n\\section*{L. STATISTICAL METHODS}","confidence":1,"confidence_rate":1},{"cnt":[[180,2007],[1944,2007],[1944,2058],[180,2058]],"region":{"top_left_x":180,"top_left_y":2006,"width":1765,"height":53},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5912be31e04348e492fa927802d87c61","type":"text","conversion_output":true,"text":"A two part hypotheses will be tested. The first hypothesis is that the children in the group fed casein","text_display":"\n\nA two part hypotheses will be tested. The first hypothesis is that the children in the group fed casein","confidence":1,"confidence_rate":1},{"cnt":[[180,2054],[1944,2054],[1944,2108],[180,2108]],"region":{"top_left_x":180,"top_left_y":2053,"width":1765,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ad992b32d4d42f4bfe6f3fc522e3ba6","type":"text","conversion_output":true,"text":"hydrolysate will have a decreased occurrence of diabetes-associated antibodies in comparison with the","text_display":" hydrolysate will have a decreased occurrence of diabetes-associated antibodies in comparison with the","confidence":1,"confidence_rate":1},{"cnt":[[180,2103],[1944,2103],[1944,2155],[180,2155]],"region":{"top_left_x":180,"top_left_y":2103,"width":1765,"height":52},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbb3c9ba723f4b3b89d5368c7e41ba24","type":"text","conversion_output":true,"text":"control group receiving conventional CM-based formula. The second hypothesis is that the group","text_display":" control group receiving conventional CM-based formula. The second hypothesis is that the group","confidence":1,"confidence_rate":1},{"cnt":[[180,2151],[1575,2151],[1575,2202],[180,2202]],"region":{"top_left_x":180,"top_left_y":2150,"width":1395,"height":53},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ce1f29ebe87492e827502a84be7b838","type":"text","conversion_output":true,"text":"weaned to a casein hydrolysate formula has a reduced incidence of type 1 diabetes.","text_display":" weaned to a casein hydrolysate formula has a reduced incidence of type 1 diabetes.","confidence":1,"confidence_rate":1},{"cnt":[[180,2239],[1944,2239],[1944,2292],[180,2292]],"region":{"top_left_x":180,"top_left_y":2238,"width":1765,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56d8d7df8cc04c85b35dc2e75f6e3ca0","type":"text","conversion_output":true,"text":"The first hypothesis will be studied based on a longitudinal data set consisting of repeated measurements","text_display":"\n\nThe first hypothesis will be studied based on a longitudinal data set consisting of repeated measurements","confidence":1,"confidence_rate":1},{"cnt":[[180,2290],[1944,2290],[1944,2340],[180,2340]],"region":{"top_left_x":180,"top_left_y":2290,"width":1765,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dbd210ccdac42449eb356b3a4634d64","type":"text","conversion_output":true,"text":"of several variables at standard time points. The variables measured at these time points are potential","text_display":" of several variables at standard time points. The variables measured at these time points are potential","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[180,2338],[1944,2338],[1944,2387],[180,2387]],"region":{"top_left_x":180,"top_left_y":2337,"width":1765,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"febd9cf3970543e8aa8c982aa88772e1","type":"text","conversion_output":true,"text":"confounding factors (i.e., factors the effects of which have not fully been eliminated by the","text_display":" confounding factors (i.e., factors the effects of which have not fully been eliminated by the","confidence":0.994140625,"confidence_rate":0.9999400364051435},{"cnt":[[180,2385],[1944,2385],[1944,2436],[180,2436]],"region":{"top_left_x":180,"top_left_y":2384,"width":1765,"height":53},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"589118b1eda24a11b5e85040d520a1ee","type":"text","conversion_output":true,"text":"randomization), effect modifying factors (such as possible occurrence of differences in weight and","text_display":" randomization), effect modifying factors (such as possible occurrence of differences in weight and","confidence":0.9990234375,"confidence_rate":0.9999905142231668},{"cnt":[[180,2432],[1944,2432],[1944,2486],[180,2486]],"region":{"top_left_x":180,"top_left_y":2432,"width":1765,"height":54},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9c811f96fe64fecbb074e3c4f913c42","type":"text","conversion_output":true,"text":"height development, which may have the ability to modify the effect of the CM exposure considered)","text_display":" height development, which may have the ability to modify the effect of the CM exposure considered)","confidence":1,"confidence_rate":1},{"cnt":[[1899,2582],[1946,2582],[1946,2623],[1899,2623]],"region":{"top_left_x":1899,"top_left_y":2582,"width":48,"height":42},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5915838a0ed34113968db355aa6557c3","type":"page_info","conversion_output":false,"text":"16","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-18","page":18,"lines":[{"cnt":[[786,150],[1296,150],[1296,200],[786,200]],"region":{"top_left_x":786,"top_left_y":150,"width":510,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"743516f29cea4c72882aa0e45cf5495a","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,296],[180,296]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3402ef95d7424c86a15f4cd37b26665d","type":"text","conversion_output":true,"text":"and the outcome variables (e.g., the status of the diabetes-associated antibodies). At every time point the","text_display":"\nand the outcome variables (e.g., the status of the diabetes-associated antibodies). At every time point the","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1944,294],[1944,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1765,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96cee9ba657d4409a7fe984cf4a9586d","type":"text","conversion_output":true,"text":"single antibody variable will be dichotomized as negative or positive, and a summary variable will be","text_display":" single antibody variable will be dichotomized as negative or positive, and a summary variable will be","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[180,339],[1944,339],[1944,393],[180,393]],"region":{"top_left_x":180,"top_left_y":339,"width":1765,"height":55},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33754201466943dca724e375a263b948","type":"text","conversion_output":true,"text":"produced (negative if less than two variables are antibody positive and positive if two or more variables","text_display":" produced (negative if less than two variables are antibody positive and positive if two or more variables","confidence":1,"confidence_rate":1},{"cnt":[[180,389],[1944,389],[1944,440],[180,440]],"region":{"top_left_x":180,"top_left_y":388,"width":1765,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7020bd68b36412aabfe936ecae31d08","type":"text","conversion_output":true,"text":"are antibody positive). The exposure to formula vs. placebo will be included in the model as an","text_display":" are antibody positive). The exposure to formula vs. placebo will be included in the model as an","confidence":1,"confidence_rate":1},{"cnt":[[180,436],[1944,436],[1944,488],[180,488]],"region":{"top_left_x":180,"top_left_y":436,"width":1765,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae9a4844ffd246278e77a84c72b2c70f","type":"text","conversion_output":true,"text":"indicator variable. Age at initiation, duration of breast feeding and/or formula use and cumulative","text_display":" indicator variable. Age at initiation, duration of breast feeding and/or formula use and cumulative","confidence":1,"confidence_rate":1},{"cnt":[[180,486],[1944,486],[1944,537],[180,537]],"region":{"top_left_x":180,"top_left_y":485,"width":1765,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad30e67801bb49879d68f77e62d6adf1","type":"text","conversion_output":true,"text":"formula dose will be included in the model as potential effect modifying and confounding factors. The","text_display":" formula dose will be included in the model as potential effect modifying and confounding factors. The","confidence":1,"confidence_rate":1},{"cnt":[[180,533],[1944,533],[1944,587],[180,587]],"region":{"top_left_x":180,"top_left_y":532,"width":1765,"height":55},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0002cac65ce4a30b7df8f3eb4b46637","type":"text","conversion_output":true,"text":"presence of interactions will be tested and the possible effect of the components considered will be","text_display":" presence of interactions will be tested and the possible effect of the components considered will be","confidence":0.9965834617614746,"confidence_rate":0.9999674063603947},{"cnt":[[180,580],[363,580],[363,629],[180,629]],"region":{"top_left_x":180,"top_left_y":580,"width":184,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec56b57dceaf43ea919f92130eb3ffc7","type":"text","conversion_output":true,"text":"estimated.","text_display":" estimated.","confidence":1,"confidence_rate":1},{"cnt":[[180,675],[1944,675],[1944,728],[180,728]],"region":{"top_left_x":180,"top_left_y":674,"width":1765,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fd9521e03c6412e9bddaff11eec5f9d","type":"text","conversion_output":true,"text":"Two different statistical methods will be used to analyze the hypothesis that weaning to a casein","text_display":"\n\nTwo different statistical methods will be used to analyze the hypothesis that weaning to a casein","confidence":1,"confidence_rate":1},{"cnt":[[180,724],[1944,724],[1944,778],[180,778]],"region":{"top_left_x":180,"top_left_y":724,"width":1765,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b3ac42738644e0286346044e81354b1","type":"text","conversion_output":true,"text":"hydrolysate decreases the occurrence of diabetes-associated antibodies. First, generalized linear models","text_display":" hydrolysate decreases the occurrence of diabetes-associated antibodies. First, generalized linear models","confidence":1,"confidence_rate":1},{"cnt":[[180,769],[1944,769],[1944,823],[180,823]],"region":{"top_left_x":180,"top_left_y":769,"width":1765,"height":54},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"683879ea7b90459e9b3cff024fb43b8c","type":"text","conversion_output":true,"text":"will be fitted to the data (20). Also random effect models will be used (21). These models which","text_display":" will be fitted to the data (20). Also random effect models will be used (21). These models which","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[180,821],[1944,821],[1944,874],[180,874]],"region":{"top_left_x":180,"top_left_y":820,"width":1765,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f26eb69c25342c28fa57f2c5deaef32","type":"text","conversion_output":true,"text":"represent a general approach to the problem of modeling repeated measurements with fairly general","text_display":" represent a general approach to the problem of modeling repeated measurements with fairly general","confidence":1,"confidence_rate":1},{"cnt":[[180,868],[1944,868],[1944,922],[180,922]],"region":{"top_left_x":180,"top_left_y":867,"width":1765,"height":55},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a90860b199f8460bbeebbdc4298a4a4b","type":"text","conversion_output":true,"text":"error structures, can allow for missing observations, serial correlations, time-varying covariates, and","text_display":" error structures, can allow for missing observations, serial correlations, time-varying covariates, and","confidence":1,"confidence_rate":1},{"cnt":[[180,915],[1944,915],[1944,969],[180,969]],"region":{"top_left_x":180,"top_left_y":915,"width":1765,"height":54},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"946cad7753184d6ab6b0ef503a228318","type":"text","conversion_output":true,"text":"irregular measurement occasions. Second, for the description of the data, the association of covariates","text_display":" irregular measurement occasions. Second, for the description of the data, the association of covariates","confidence":1,"confidence_rate":1},{"cnt":[[180,965],[1944,965],[1944,1016],[180,1016]],"region":{"top_left_x":180,"top_left_y":964,"width":1765,"height":53},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a8d8e3d92b643c2acd6ae7407133fe0","type":"text","conversion_output":true,"text":"with the risk of an elevated antibody at a given point of time will be assessed using logistic regression","text_display":" with the risk of an elevated antibody at a given point of time will be assessed using logistic regression","confidence":1,"confidence_rate":1},{"cnt":[[180,1010],[1626,1010],[1626,1068],[180,1068]],"region":{"top_left_x":180,"top_left_y":1009,"width":1447,"height":59},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccc4d79a33534ce691608d56c5abe779","type":"text","conversion_output":true,"text":"models (22). A rather similar statistical approach was used in the DCCT Study (23).","text_display":" models (22). A rather similar statistical approach was used in the DCCT Study (23).","confidence":1,"confidence_rate":1},{"cnt":[[180,1104],[1944,1104],[1944,1160],[180,1160]],"region":{"top_left_x":180,"top_left_y":1104,"width":1765,"height":57},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"264195c55429466b8703e378a4a8bdb5","type":"text","conversion_output":true,"text":"The analyses of the second hypothesis will use the time of diagnosis of manifest type 1 diabetes as the","text_display":"\n\nThe analyses of the second hypothesis will use the time of diagnosis of manifest type 1 diabetes as the","confidence":1,"confidence_rate":1},{"cnt":[[180,1156],[1944,1156],[1944,1210],[180,1210]],"region":{"top_left_x":180,"top_left_y":1155,"width":1765,"height":55},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f299b2b2092a47cea9e554b1c39d2150","type":"text","conversion_output":true,"text":"only outcome measure. The dataset will thus be similar to that of a cohort study, and the statistical","text_display":" only outcome measure. The dataset will thus be similar to that of a cohort study, and the statistical","confidence":0.9912109375,"confidence_rate":0.999916721259154},{"cnt":[[180,1203],[1944,1203],[1944,1257],[180,1257]],"region":{"top_left_x":180,"top_left_y":1203,"width":1765,"height":54},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6aa10ca37b94404fbd405b4010e92edb","type":"text","conversion_output":true,"text":"analyses will be carried out using the proportional hazards regression model (24) including the milk","text_display":" analyses will be carried out using the proportional hazards regression model (24) including the milk","confidence":0.62255859375,"confidence_rate":0.9954966702629631},{"cnt":[[180,1250],[1944,1250],[1944,1304],[180,1304]],"region":{"top_left_x":180,"top_left_y":1250,"width":1765,"height":55},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6959b6618b814e2d97a06b2defe68da1","type":"text","conversion_output":true,"text":"exposure as the risk factor and potential confounding factors a covariates in the model. Also time-","text_display":" exposure as the risk factor and potential confounding factors a covariates in the model. Also time","confidence":1,"confidence_rate":1},{"cnt":[[180,1298],[1944,1298],[1944,1351],[180,1351]],"region":{"top_left_x":180,"top_left_y":1297,"width":1765,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e6e1799608341ff8b9ab89539fca807","type":"text","conversion_output":true,"text":"dependent covariates can be included to assess the effects of potential modifying factors. The adjusted","text_display":"dependent covariates can be included to assess the effects of potential modifying factors. The adjusted","confidence":1,"confidence_rate":1},{"cnt":[[180,1347],[1944,1347],[1944,1401],[180,1401]],"region":{"top_left_x":180,"top_left_y":1347,"width":1765,"height":54},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d918bdee5f624d87a24696bf292bb0cd","type":"text","conversion_output":true,"text":"relative risk of type 1 diabetes between the two groups of milk exposure will be estimated. Also the","text_display":" relative risk of type 1 diabetes between the two groups of milk exposure will be estimated. Also the","confidence":1,"confidence_rate":1},{"cnt":[[180,1396],[1319,1396],[1319,1450],[180,1450]],"region":{"top_left_x":180,"top_left_y":1396,"width":1140,"height":55},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba062932da27443ba2ed4eb74a155050","type":"text","conversion_output":true,"text":"adjusted incidence of the disease in the two groups can be assessed.","text_display":" adjusted incidence of the disease in the two groups can be assessed.","confidence":1,"confidence_rate":1},{"cnt":[[782,1534],[1336,1534],[1336,1592],[782,1592]],"region":{"top_left_x":782,"top_left_y":1533,"width":555,"height":59},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04991c1bee37407d8dd0ab3a626a972a","type":"section_header","conversion_output":false,"children_ids":["efc2d66dfad44aca9a0daa3c0981f0f9"],"text":"","text_display":""},{"cnt":[[791,1540],[1330,1540],[1330,1588],[791,1588]],"region":{"top_left_x":790,"top_left_y":1540,"width":540,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efc2d66dfad44aca9a0daa3c0981f0f9","type":"text","conversion_output":true,"parent_id":"04991c1bee37407d8dd0ab3a626a972a","text":"M. INTERIM ANALYSIS","text_display":"\n\n\\section*{M. INTERIM ANALYSIS}","confidence":1,"confidence_rate":1},{"cnt":[[180,1635],[1944,1635],[1944,1687],[180,1687]],"region":{"top_left_x":180,"top_left_y":1634,"width":1765,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"545ca55d0dd144a4a971df881755eec7","type":"text","conversion_output":true,"text":"An interim analysis of autoantibodies and clinical diabetes will be performed repeatedly by the Data","text_display":"\n\nAn interim analysis of autoantibodies and clinical diabetes will be performed repeatedly by the Data","confidence":1,"confidence_rate":1},{"cnt":[[180,1680],[1944,1680],[1944,1734],[180,1734]],"region":{"top_left_x":180,"top_left_y":1680,"width":1765,"height":54},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5cc48794d6744d8ad7583536e7da361","type":"text","conversion_output":true,"text":"Safety and Monitoring Board, beginning 2 years after the last subject is recruited, in order to ensure that","text_display":" Safety and Monitoring Board, beginning 2 years after the last subject is recruited, in order to ensure that","confidence":1,"confidence_rate":1},{"cnt":[[180,1732],[1944,1732],[1944,1781],[180,1781]],"region":{"top_left_x":180,"top_left_y":1731,"width":1765,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ae54eec8d0a4e1b8dbd90b26c996a78","type":"text","conversion_output":true,"text":"an unexpectedly large protective effect of the intervention will be detected early. Although the follow-","text_display":" an unexpectedly large protective effect of the intervention will be detected early. Although the follow","confidence":1,"confidence_rate":1},{"cnt":[[180,1779],[1944,1779],[1944,1833],[180,1833]],"region":{"top_left_x":180,"top_left_y":1778,"width":1765,"height":55},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14440ce5d04e4f42bebb07719d03279b","type":"text","conversion_output":true,"text":"up will be continued, the code will be opened and the results published if either of these analyses reach","text_display":"up will be continued, the code will be opened and the results published if either of these analyses reach","confidence":1,"confidence_rate":1},{"cnt":[[180,1826],[1635,1826],[1635,1880],[180,1880]],"region":{"top_left_x":180,"top_left_y":1826,"width":1455,"height":54},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8baeae977a444b4bd9ca7bba8bd272e","type":"text","conversion_output":true,"text":"sufficient statistical significance, as defined by the Data Safety and Monitoring Board.","text_display":" sufficient statistical significance, as defined by the Data Safety and Monitoring Board.","confidence":1,"confidence_rate":1},{"cnt":[[821,1964],[1300,1964],[1300,2026],[821,2026]],"region":{"top_left_x":820,"top_left_y":1963,"width":480,"height":63},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8911c920f7ec483db139e3d3beaa5c81","type":"section_header","conversion_output":false,"children_ids":["9e3b5dcafbfe4d9dadf8bce6f32918dc"],"text":"","text_display":""},{"cnt":[[829,1972],[1293,1972],[1293,2017],[829,2017]],"region":{"top_left_x":829,"top_left_y":1972,"width":465,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e3b5dcafbfe4d9dadf8bce6f32918dc","type":"text","conversion_output":true,"parent_id":"8911c920f7ec483db139e3d3beaa5c81","text":"N. ETHICAL ISSUES","text_display":"\n\n\\section*{N. ETHICAL ISSUES}","confidence":1,"confidence_rate":1},{"cnt":[[180,2067],[1944,2067],[1944,2121],[180,2121]],"region":{"top_left_x":180,"top_left_y":2066,"width":1765,"height":55},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f436ca929a548d9b2fc8a126ea2330a","type":"text","conversion_output":true,"text":"Ethical approval has been obtained at each study center. Written informed consent is requested from the","text_display":"\n\nEthical approval has been obtained at each study center. Written informed consent is requested from the","confidence":1,"confidence_rate":1},{"cnt":[[180,2114],[1946,2114],[1946,2168],[180,2168]],"region":{"top_left_x":180,"top_left_y":2114,"width":1767,"height":54},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4f02346501649dca726bf0ab21af5b9","type":"text","conversion_output":true,"text":"parents and if needed also from the child. If, during the course of this study, an alternative strategy for","text_display":" parents and if needed also from the child. If, during the course of this study, an alternative strategy for","confidence":1,"confidence_rate":1},{"cnt":[[180,2161],[1944,2161],[1944,2215],[180,2215]],"region":{"top_left_x":180,"top_left_y":2161,"width":1765,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a45a7e3a225f4f85bef030259160ce80","type":"text","conversion_output":true,"text":"diabetes prevention is proven to be effective, then we will inform the families of this possibility and","text_display":" diabetes prevention is proven to be effective, then we will inform the families of this possibility and","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[180,2211],[1059,2211],[1059,2262],[180,2262]],"region":{"top_left_x":180,"top_left_y":2210,"width":880,"height":53},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4d8fa45c97f44f9a730b71efe254a14","type":"text","conversion_output":true,"text":"discuss, and likely offer its use in a rational fashion.","text_display":" discuss, and likely offer its use in a rational fashion.","confidence":1,"confidence_rate":1},{"cnt":[[180,2305],[1876,2305],[1876,2361],[180,2361]],"region":{"top_left_x":180,"top_left_y":2305,"width":1696,"height":57},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3adf0aceec724535904905c9515e2e96","type":"text","conversion_output":true,"text":"Detailed HLA information will be released by qualified personnel only on the request by the parents.","text_display":"\n\nDetailed HLA information will be released by qualified personnel only on the request by the parents.","confidence":1,"confidence_rate":1},{"cnt":[[1899,2582],[1946,2582],[1946,2625],[1899,2625]],"region":{"top_left_x":1899,"top_left_y":2582,"width":48,"height":44},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c5c68a34c3724e3b9ee69d0af12f411a","type":"page_info","conversion_output":false,"text":"17","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-19","page":19,"lines":[{"cnt":[[786,150],[1296,150],[1296,200],[786,200]],"region":{"top_left_x":786,"top_left_y":150,"width":510,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b8e5e28eef54a648a0e76abaf6fb3d6","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,245],[1944,245],[1944,296],[180,296]],"region":{"top_left_x":180,"top_left_y":244,"width":1765,"height":53},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7639bbce7d3c4f44af21188f3487ca2d","type":"text","conversion_output":true,"text":"The diabetes associated autoantibody results will be disclosed to the families after each annual visit","text_display":"\n\nThe diabetes associated autoantibody results will be disclosed to the families after each annual visit","confidence":1,"confidence_rate":1},{"cnt":[[180,294],[1944,294],[1944,346],[180,346]],"region":{"top_left_x":180,"top_left_y":294,"width":1765,"height":52},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa1f1ea417ae451989e2f2ff04689c4c","type":"text","conversion_output":true,"text":"starting from the 6 -year visit. The family will be informed by the Study Center as soon as the","text_display":" starting from the 6 -year visit. The family will be informed by the Study Center as soon as the","confidence":0.73681640625,"confidence_rate":0.9970391828863868},{"cnt":[[180,344],[930,344],[930,393],[180,393]],"region":{"top_left_x":180,"top_left_y":343,"width":751,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85fea28e28cc4ac2b47efb3f5e9aced6","type":"text","conversion_output":true,"text":"autoantibody results have become available.","text_display":" autoantibody results have become available.","confidence":1,"confidence_rate":1},{"cnt":[[434,477],[1697,477],[1697,544],[434,544]],"region":{"top_left_x":433,"top_left_y":476,"width":1265,"height":68},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cac0f550ac443368b6d9ef0df824c8c","type":"section_header","conversion_output":false,"children_ids":["06dd4b0e7c304a939aaf59822aaee927"],"text":"","text_display":""},{"cnt":[[443,483],[1691,483],[1691,535],[443,535]],"region":{"top_left_x":442,"top_left_y":483,"width":1249,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06dd4b0e7c304a939aaf59822aaee927","type":"text","conversion_output":true,"parent_id":"0cac0f550ac443368b6d9ef0df824c8c","text":"O. TRAINING, PROJECT PLANNING AND TIME TABLE","text_display":"\n\n\\section*{O. TRAINING, PROJECT PLANNING AND TIME TABLE}","confidence":1,"confidence_rate":1},{"cnt":[[180,580],[1944,580],[1944,632],[180,632]],"region":{"top_left_x":180,"top_left_y":580,"width":1765,"height":52},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"caeec48a35ed4d03a7a6dc5f8fbaee6a","type":"text","conversion_output":true,"text":"To achieve standardization in the implementation of the study protocol, a detailed training program for","text_display":"\n\nTo achieve standardization in the implementation of the study protocol, a detailed training program for","confidence":1,"confidence_rate":1},{"cnt":[[180,629],[1944,629],[1944,681],[180,681]],"region":{"top_left_x":180,"top_left_y":629,"width":1765,"height":53},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"369d9998e81b4c1688f2548b20902774","type":"text","conversion_output":true,"text":"the study personnel is essential. The national coordinators, nurse and nutrition coordinators participate","text_display":" the study personnel is essential. The national coordinators, nurse and nutrition coordinators participate","confidence":1,"confidence_rate":1},{"cnt":[[180,677],[1944,677],[1944,728],[180,728]],"region":{"top_left_x":180,"top_left_y":676,"width":1765,"height":53},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34d403b949e44abf9561503d0bb5d4f4","type":"text","conversion_output":true,"text":"at vital training sessions in their respective regions. We will utilize the experience gained during the","text_display":" at vital training sessions in their respective regions. We will utilize the experience gained during the","confidence":1,"confidence_rate":1},{"cnt":[[180,726],[1944,726],[1944,776],[180,776]],"region":{"top_left_x":180,"top_left_y":726,"width":1765,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20a6c22781c146819745e2b9dcf96c3b","type":"text","conversion_output":true,"text":"second pilot study in training and informing the national investigators and their staff, when we expanded","text_display":" second pilot study in training and informing the national investigators and their staff, when we expanded","confidence":1,"confidence_rate":1},{"cnt":[[180,773],[1944,773],[1944,823],[180,823]],"region":{"top_left_x":180,"top_left_y":773,"width":1765,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b741588962649c5a02769344bb41b41","type":"text","conversion_output":true,"text":"the study to Sweden, Estonia and Hungary (investigators' meetings, site visits by project staff etc.).","text_display":" the study to Sweden, Estonia and Hungary (investigators' meetings, site visits by project staff etc.).","confidence":0.9677734375,"confidence_rate":0.9996939041347569},{"cnt":[[180,821],[1944,821],[1944,872],[180,872]],"region":{"top_left_x":180,"top_left_y":820,"width":1765,"height":53},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b6e9a99a7ee465a8387de39c281b7ea","type":"text","conversion_output":true,"text":"Additional training is provided by the Monitors and other clinical team mentors to their counterparts","text_display":" Additional training is provided by the Monitors and other clinical team mentors to their 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The scale of the study is dictated by the logistics of recruitment, the necessity of","confidence":1,"confidence_rate":1},{"cnt":[[180,1061],[1944,1061],[1944,1111],[180,1111]],"region":{"top_left_x":180,"top_left_y":1061,"width":1765,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b6d56b8e4884e04ab95c169173495e7","type":"text","conversion_output":true,"text":"completion within a reasonable period of time, and the need for ethnic diversity in the study populations.","text_display":" completion within a reasonable period of time, and the need for ethnic diversity in the study populations.","confidence":1,"confidence_rate":1},{"cnt":[[180,1109],[1944,1109],[1944,1160],[180,1160]],"region":{"top_left_x":180,"top_left_y":1108,"width":1765,"height":53},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"124c3032073d46e4944581bec9a2e17a","type":"text","conversion_output":true,"text":"Based on the successful development and execution of TRIGR pilot studies, the central coordinating","text_display":" Based on the successful development and execution of TRIGR pilot studies, the central coordinating","confidence":1,"confidence_rate":1},{"cnt":[[180,1156],[1944,1156],[1944,1205],[180,1205]],"region":{"top_left_x":180,"top_left_y":1155,"width":1765,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21eaf147f8be4dca986fb0d7c8ff0540","type":"text","conversion_output":true,"text":"center with the study PI will continue to be located in Helsinki (Dr. M. Knip and his deputy, Dr. H.K.","text_display":" center with the study PI will continue to be located in Helsinki (Dr. M. Knip and his deputy, Dr. H.K.","confidence":1,"confidence_rate":1},{"cnt":[[180,1199],[1944,1199],[1944,1257],[180,1257]],"region":{"top_left_x":180,"top_left_y":1198,"width":1765,"height":59},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddb66649ec1a4b7bad2cc3be2b26e0dc","type":"text","conversion_output":true,"text":"Åkerblom (PI until July 1, 2008). The two major regional groups will be: 1. Europe, with a coordinating","text_display":" Åkerblom (PI until July 1, 2008). The two major regional groups will be: 1. Europe, with a coordinating","confidence":0.5992186069488525,"confidence_rate":0.9953125910474803},{"cnt":[[180,1250],[1944,1250],[1944,1302],[180,1302]],"region":{"top_left_x":180,"top_left_y":1250,"width":1765,"height":52},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"708852d784ed4e7d827af4130bb64a08","type":"text","conversion_output":true,"text":"center in Helsinki; 2._North America with a coordinating center in Pittsburgh, PA (Dr. D. Becker) and a","text_display":" center in Helsinki; 2._North America with a coordinating center in Pittsburgh, PA (Dr. D. Becker) and a","confidence":1,"confidence_rate":1},{"cnt":[[180,1300],[1944,1300],[1944,1351],[180,1351]],"region":{"top_left_x":180,"top_left_y":1299,"width":1765,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"34a78141741e4440b042f6c8ec00cab5","type":"text","conversion_output":true,"text":"co-coordinating center in London, Ont. (Dr. J. Dupré). Each of these regional groups is multicentered,","text_display":" co-coordinating center in London, Ont. (Dr. J. Dupré). Each of these regional groups is multicentered,","confidence":1,"confidence_rate":1},{"cnt":[[180,1349],[1944,1349],[1944,1399],[180,1399]],"region":{"top_left_x":180,"top_left_y":1349,"width":1765,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efb47d20b37a4a71bc3942fbb8fadfb0","type":"text","conversion_output":true,"text":"as described in Appendix 1. The trial is nationwide in Finland, Germany, the Netherlands and Canada.","text_display":" as described in Appendix 1. The trial is nationwide in Finland, Germany, the Netherlands and Canada.","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[180,1396],[1946,1396],[1946,1446],[180,1446]],"region":{"top_left_x":180,"top_left_y":1396,"width":1767,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6774e5d0216e4686b50bea3406c8ebd6","type":"text","conversion_output":true,"text":"Satellite centers with investigators who have participated in the development of TRIGR, in New South","text_display":" Satellite centers with investigators who have participated in the development of TRIGR, in New South","confidence":1,"confidence_rate":1},{"cnt":[[180,1444],[1949,1444],[1949,1495],[180,1495]],"region":{"top_left_x":180,"top_left_y":1443,"width":1769,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c106bc40878413db7ae82d944b9d336","type":"text","conversion_output":true,"text":"Wales, Australia, will be 'attached' to the European group. The central major organization functions of","text_display":" Wales, Australia, will be 'attached' to the European group. The central major organization functions of","confidence":1,"confidence_rate":1},{"cnt":[[180,1491],[1946,1491],[1946,1543],[180,1543]],"region":{"top_left_x":180,"top_left_y":1491,"width":1767,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2620a0b8c5ec4177b779aa1ddef3415f","type":"text","conversion_output":true,"text":"the study will be carried out in Helsinki and Tampa. These functions include data acquisition, processing","text_display":" the study will be carried out in Helsinki and Tampa. These functions include data acquisition, processing","confidence":1,"confidence_rate":1},{"cnt":[[180,1538],[1944,1538],[1944,1592],[180,1592]],"region":{"top_left_x":180,"top_left_y":1538,"width":1765,"height":54},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba602241c6124c4fb5f0a53d1f023c01","type":"text","conversion_output":true,"text":"and storage, randomization and protocol administration. Monitoring and budgetary administration will","text_display":" and storage, randomization and protocol administration. Monitoring and budgetary administration will","confidence":1,"confidence_rate":1},{"cnt":[[180,1588],[1244,1588],[1244,1639],[180,1639]],"region":{"top_left_x":180,"top_left_y":1587,"width":1064,"height":53},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffacacdc1ad34cf4801d9f3ee660dc8d","type":"text","conversion_output":true,"text":"be carried out by the three major regional coordinating centers.","text_display":" be carried out by the three major regional coordinating centers.","confidence":1,"confidence_rate":1},{"cnt":[[180,1684],[1944,1684],[1944,1734],[180,1734]],"region":{"top_left_x":180,"top_left_y":1684,"width":1765,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f04777b0755461e9ae6d10b323c71cd","type":"text","conversion_output":true,"text":"The essential laboratory functions required for TRIGR will be conducted in three central internationally","text_display":"\n\nThe essential laboratory functions required for TRIGR will be conducted in three central internationally","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[180,1732],[1944,1732],[1944,1781],[180,1781]],"region":{"top_left_x":180,"top_left_y":1731,"width":1765,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8eff95130d1457ab04ad83b0663ce49","type":"text","conversion_output":true,"text":"recognized study laboratories 1. for determination of diabetes-related autoantibodies (Dr. M. Knip,","text_display":" recognized study laboratories 1. for determination of diabetes-related autoantibodies (Dr. M. Knip,","confidence":0.9951171875,"confidence_rate":0.9999529359885383},{"cnt":[[180,1779],[1944,1779],[1944,1828],[180,1828]],"region":{"top_left_x":180,"top_left_y":1778,"width":1765,"height":51},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f450af909434e3386b18d8eeeaaac16","type":"text","conversion_output":true,"text":"Helsinki), and 2. for determination of compliance through measurements of CM antibodies (Dr. E.","text_display":" Helsinki), and 2. for determination of compliance through measurements of CM antibodies (Dr. E.","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[180,1826],[1944,1826],[1944,1878],[180,1878]],"region":{"top_left_x":180,"top_left_y":1826,"width":1765,"height":52},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f358343b470b434e97e3f5e0820f59c2","type":"text","conversion_output":true,"text":"Savilahti, Helsinki) 3. MHC typing with optimized turnaround time for Europe will involve the","text_display":" Savilahti, Helsinki) 3. MHC typing with optimized turnaround time for Europe will involve the","confidence":0.99951171875,"confidence_rate":0.9999950163338663},{"cnt":[[180,1876],[1944,1876],[1944,1927],[180,1927]],"region":{"top_left_x":180,"top_left_y":1875,"width":1765,"height":53},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0cb8c112ac3544539dc2eda06b73a182","type":"text","conversion_output":true,"text":"laboratory in Turku, Finland (Dr. J. Ilonen). These laboratories served the same functions in the human","text_display":" laboratory in Turku, Finland (Dr. J. Ilonen). These laboratories served the same functions in the human","confidence":1,"confidence_rate":1},{"cnt":[[180,1921],[1944,1921],[1944,1974],[180,1974]],"region":{"top_left_x":180,"top_left_y":1920,"width":1765,"height":55},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30bc8b4978ed424fbac29e2829146894","type":"text","conversion_output":true,"text":"pilot studies. An experienced MHC laboratory in Pittsburgh, PA (Dr. M. Trucco) has been added to","text_display":" pilot studies. An experienced MHC laboratory in Pittsburgh, PA (Dr. M. Trucco) has been added to","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[180,1972],[1944,1972],[1944,2022],[180,2022]],"region":{"top_left_x":180,"top_left_y":1972,"width":1765,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80308584546e443094733eb09ce2db57","type":"text","conversion_output":true,"text":"serve the North American centers with rapid turnaround time. Pilot experiments have been performed to","text_display":" serve the North American centers with rapid turnaround time. Pilot experiments have been performed to","confidence":1,"confidence_rate":1},{"cnt":[[180,2020],[1944,2020],[1944,2069],[180,2069]],"region":{"top_left_x":180,"top_left_y":2019,"width":1765,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b47231196144082960a211906fcfc5f","type":"text","conversion_output":true,"text":"optimize tissue typing for the satellites. Dr. S.M. Virtanen will be responsible for the analysis of dietary","text_display":" optimize tissue typing for the satellites. Dr. S.M. Virtanen will be responsible for the analysis of dietary","confidence":1,"confidence_rate":1},{"cnt":[[180,2067],[273,2067],[273,2112],[180,2112]],"region":{"top_left_x":180,"top_left_y":2066,"width":93,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e49bca48ebf4d98aa2ffaf2549c57e1","type":"text","conversion_output":true,"text":"data.","text_display":" data.","confidence":1,"confidence_rate":1},{"cnt":[[180,2161],[1944,2161],[1944,2215],[180,2215]],"region":{"top_left_x":180,"top_left_y":2161,"width":1765,"height":55},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6df60bb781a471484214140c1379079","type":"text","conversion_output":true,"text":"Three regional fiscal units in Helsinki (Europe), London (Canada), and Pittsburgh (USA) will be","text_display":"\n\nThree regional fiscal units in Helsinki (Europe), London (Canada), and Pittsburgh (USA) will be","confidence":1,"confidence_rate":1},{"cnt":[[180,2211],[1944,2211],[1944,2262],[180,2262]],"region":{"top_left_x":180,"top_left_y":2210,"width":1765,"height":53},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d45c1f53f28647a48c632b6f37beaecc","type":"text","conversion_output":true,"text":"responsible for operations in these respective regions, and for acquisition and transfer of data to the","text_display":" responsible for operations in these respective regions, and for acquisition and transfer of data to the","confidence":1,"confidence_rate":1},{"cnt":[[180,2260],[1944,2260],[1944,2310],[180,2310]],"region":{"top_left_x":180,"top_left_y":2260,"width":1765,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"beff7f84a9be41cf979e5c77676aec08","type":"text","conversion_output":true,"text":"DMU in Tampa, Florida. However, for governance purposes North America and Europe constitute two","text_display":" DMU in Tampa, Florida. However, for governance purposes North America and Europe constitute two","confidence":1,"confidence_rate":1},{"cnt":[[180,2307],[1944,2307],[1944,2357],[180,2357]],"region":{"top_left_x":180,"top_left_y":2307,"width":1765,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f82642e958fe48b588ab9c4c6e9032ef","type":"text","conversion_output":true,"text":"governance regions. Communication among participants in each region will be largely by electronic","text_display":" governance regions. Communication among participants in each region will be largely by electronic","confidence":1,"confidence_rate":1},{"cnt":[[180,2355],[1944,2355],[1944,2404],[180,2404]],"region":{"top_left_x":180,"top_left_y":2354,"width":1765,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12d90868fa804a43b98d6cf661d17268","type":"text","conversion_output":true,"text":"means, but group meetings will be essential during the initiation of the study, and throughout the","text_display":" means, but group meetings will be essential during the initiation of the study, and throughout the","confidence":1,"confidence_rate":1},{"cnt":[[180,2402],[1944,2402],[1944,2454],[180,2454]],"region":{"top_left_x":180,"top_left_y":2401,"width":1765,"height":53},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ac729f4bc374299bf4c32e56cae9b24","type":"text","conversion_output":true,"text":"recruitment and treatment phase. Special provision will be required for communication among, and","text_display":" recruitment and treatment phase. Special provision will be required for communication among, and","confidence":1,"confidence_rate":1},{"cnt":[[180,2449],[1876,2449],[1876,2503],[180,2503]],"region":{"top_left_x":180,"top_left_y":2449,"width":1696,"height":54},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfb890b53f704fc092550287dfdf4cd0","type":"text","conversion_output":true,"text":"support of, the trial coordinators modeled after the DCCT and its epidemiological follow-up (EDIC).","text_display":" support of, the trial coordinators modeled after the DCCT and its epidemiological follow-up (EDIC).","confidence":1,"confidence_rate":1},{"cnt":[[1895,2582],[1955,2582],[1955,2628],[1895,2628]],"region":{"top_left_x":1894,"top_left_y":2582,"width":62,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e17fa02ccb3402382a8d3b11f1ba782","type":"page_info","conversion_output":false,"text":"20","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"69180ea7-69b0-4331-9c2e-a0bc0a5a9be6-22","page":22,"lines":[{"cnt":[[786,150],[1293,150],[1293,200],[786,200]],"region":{"top_left_x":786,"top_left_y":150,"width":508,"height":50},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43c5c7569a774ee8b62244480766a894","type":"page_info","conversion_output":false,"text":"Protocol - revised April 2015","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[180,296],[406,296],[406,339],[180,339]],"region":{"top_left_x":180,"top_left_y":296,"width":227,"height":44},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fdbd4b2218a417f868bf7c7a35c9fa3","type":"section_header","conversion_output":false,"children_ids":["54575abfe5474221a3a1901715cb0a95"],"text":"","text_display":""},{"cnt":[[185,301],[402,301],[402,337],[185,337]],"region":{"top_left_x":184,"top_left_y":300,"width":218,"height":38},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54575abfe5474221a3a1901715cb0a95","type":"text","conversion_output":true,"parent_id":"3fdbd4b2218a417f868bf7c7a35c9fa3","text":"Committees","text_display":"\n\n\\section*{Committees}","confidence":1,"confidence_rate":1},{"cnt":[[185,357],[1940,357],[1940,406],[185,406]],"region":{"top_left_x":184,"top_left_y":356,"width":1757,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2918e15195534c25a4076bcb1fb80f00","type":"text","conversion_output":true,"text":"The two Regional Executive Committees will maintain effective electronic communication among the","text_display":"\n\nThe two Regional Executive Committees will maintain effective electronic communication among the","confidence":1,"confidence_rate":1},{"cnt":[[185,406],[1940,406],[1940,453],[185,453]],"region":{"top_left_x":184,"top_left_y":406,"width":1757,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05bf67d0a4b34e1a9082c92bad384ae0","type":"text","conversion_output":true,"text":"regions, with personal meetings of representatives as needed, through the TRIGR International","text_display":" regions, with personal meetings of representatives as needed, through the TRIGR International","confidence":1,"confidence_rate":1},{"cnt":[[185,451],[1940,451],[1940,501],[185,501]],"region":{"top_left_x":184,"top_left_y":451,"width":1757,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74757b222cfd438880e26cbb94470cc5","type":"text","conversion_output":true,"text":"Executive Committee (IEC). This coordinating committee will be under the Chairmanship of the lead","text_display":" Executive Committee (IEC). This coordinating committee will be under the Chairmanship of the lead","confidence":1,"confidence_rate":1},{"cnt":[[183,501],[1940,501],[1940,550],[183,550]],"region":{"top_left_x":182,"top_left_y":500,"width":1759,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3ff5f303bdf473b9cb4f48e1d87d0c9","type":"text","conversion_output":true,"text":"principal investigator or his delegate, with the co-chairmanship of the national coordinators in Canada","text_display":" principal investigator or his delegate, with the co-chairmanship of the national coordinators in Canada","confidence":1,"confidence_rate":1},{"cnt":[[183,550],[1944,550],[1944,597],[183,597]],"region":{"top_left_x":182,"top_left_y":550,"width":1763,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50c4e3a217f548f386918d2da73af12d","type":"text","conversion_output":true,"text":"and United States or their delegates, and with representation of the several constituencies in the study","text_display":" and United States or their delegates, and with representation of the several constituencies in the study","confidence":1,"confidence_rate":1},{"cnt":[[185,604],[312,604],[312,647],[185,647]],"region":{"top_left_x":184,"top_left_y":603,"width":128,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98dcc14b89614b9d8b18dd032bbc1a78","type":"text","conversion_output":true,"text":"groups.","text_display":" groups.","confidence":1,"confidence_rate":1},{"cnt":[[183,692],[1940,692],[1940,741],[183,741]],"region":{"top_left_x":182,"top_left_y":691,"width":1759,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"809195f5ae3d414595d770de13da40c5","type":"text","conversion_output":true,"text":"The Data Safety and Monitoring Board supervises the safety issues in the study, and performs the","text_display":"\n\nThe Data Safety and Monitoring Board supervises the safety issues in the study, and performs the","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[185,741],[1940,741],[1940,788],[185,788]],"region":{"top_left_x":184,"top_left_y":741,"width":1757,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87dc256787ee4496864d5d3703f61695","type":"text","conversion_output":true,"text":"interim analyses, described above. It also supervises compliance issues, like the interpretation of CM","text_display":" interim analyses, described above. 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Kimpimäki T, Kulmala P, Savola K, Vähäsalo P, Reijonen H, Ilonen J, Åkerblom HK, Knip M, the","text_display":"\n1. Kimpimäki T, Kulmala P, Savola K, Vähäsalo P, Reijonen H, Ilonen J, Åkerblom HK, Knip M, the","confidence":1,"confidence_rate":1},{"cnt":[[254,2041],[1803,2041],[1803,2090],[254,2090]],"region":{"top_left_x":253,"top_left_y":2041,"width":1550,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2be08f18af1e4a388c8f045eb50ee955","type":"text","conversion_output":true,"text":"Childhood Diabetes in Finland Study Group. Disease-associated autoantibodies as surrogate","text_display":" Childhood Diabetes in Finland Study Group. Disease-associated autoantibodies as surrogate","confidence":1,"confidence_rate":1},{"cnt":[[256,2088],[1893,2088],[1893,2138],[256,2138]],"region":{"top_left_x":255,"top_left_y":2088,"width":1638,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"948f93be8ea84e0cbdb3cfdb5911c688","type":"text","conversion_output":true,"text":"markers of type 1 diabetes in young children at increased genetic risk. J. Clin. Endocrinol. Metab.","text_display":" markers of type 1 diabetes in young children at increased genetic risk. J. Clin. Endocrinol. Metab.","confidence":1,"confidence_rate":1},{"cnt":[[254,2138],[625,2138],[625,2181],[254,2181]],"region":{"top_left_x":253,"top_left_y":2137,"width":373,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e65bb832e4c46cbb63ee9470fd10af8","type":"text","conversion_output":true,"text":"2000: 85: 1126-1132.","text_display":" 2000: 85: 1126-1132.","confidence":1,"confidence_rate":1},{"cnt":[[180,2185],[1843,2185],[1843,2232],[180,2232]],"region":{"top_left_x":180,"top_left_y":2184,"width":1664,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"291a9f002583453aaadd213ca1054d59","type":"text","conversion_output":true,"text":"2. Schenker M, Hummel M, Ferber K, Walter M, Keller E, Albert ED, Janka H-U, Kastendiek C,","text_display":"\n2. 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(B) HLA class II associations in insulin-dependent diabetes mellitus among Blacks,","text_display":" Thorsby E. (B) HLA class II associations in insulin-dependent diabetes mellitus among Blacks,","confidence":1,"confidence_rate":1},{"cnt":[[254,1059],[1835,1059],[1835,1113],[254,1113]],"region":{"top_left_x":253,"top_left_y":1059,"width":1582,"height":54},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72a16e19444143cd90b51daddbf48243","type":"text","conversion_output":true,"text":"Caucasoids, and Japanese. In: K Tsuji, M Aizawa, T Sasazuki, eds, HLA 1991 Vol 1, Oxford","text_display":" Caucasoids, and Japanese. 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Savola K, Sabbah E, Kulmala P, Vähäsalo P, Ilonen J, Knip M. Autoantibodies associated with","confidence":1,"confidence_rate":1},{"cnt":[[254,438],[1846,438],[1846,490],[254,490]],"region":{"top_left_x":253,"top_left_y":438,"width":1593,"height":52},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c4f4e3c32734980b678c15a6360b016","type":"text","conversion_output":true,"text":"Type 1 diabetes mellitus persist after diagnosis in children. Diabetologia 1998: 41: 1293-1297.","text_display":" Type 1 diabetes mellitus persist after diagnosis in children. Diabetologia 1998: 41: 1293-1297.","confidence":1,"confidence_rate":1},{"cnt":[[185,486],[1835,486],[1835,537],[185,537]],"region":{"top_left_x":184,"top_left_y":485,"width":1651,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10402a5c702140c280ca6f9b77b7f80f","type":"text","conversion_output":true,"text":"19. 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IA-2","confidence":1,"confidence_rate":1},{"cnt":[[254,580],[1772,580],[1772,629],[254,629]],"region":{"top_left_x":253,"top_left_y":580,"width":1520,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd2544da5d6448f2814db711344b18c0","type":"text","conversion_output":true,"text":"antibodies - a sensitive marker of IDDM with clinical onset in childhood and adolescence.","text_display":" antibodies - a sensitive marker of IDDM with clinical onset in childhood and adolescence.","confidence":1,"confidence_rate":1},{"cnt":[[254,627],[810,627],[810,679],[254,679]],"region":{"top_left_x":253,"top_left_y":627,"width":557,"height":52},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13e32dcaad2f4b84873e2d0ddf3adc88","type":"text","conversion_output":true,"text":"Diabetologia 1998: 41: 424-429.","text_display":" Diabetologia 1998: 41: 424-429.","confidence":1,"confidence_rate":1},{"cnt":[[180,675],[1936,675],[1936,728],[180,728]],"region":{"top_left_x":180,"top_left_y":674,"width":1756,"height":55},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99094e8dc26e426f8874f27dfacd1946","type":"text","conversion_output":true,"text":"20. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986:","text_display":"\n20. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986:","confidence":1,"confidence_rate":1},{"cnt":[[254,726],[438,726],[438,771],[254,771]],"region":{"top_left_x":253,"top_left_y":726,"width":186,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4133b00341aa4be39fab294b68db37b6","type":"text","conversion_output":true,"text":"73: 13-22.","text_display":" 73: 13-22.","confidence":1,"confidence_rate":1},{"cnt":[[180,769],[1934,769],[1934,823],[180,823]],"region":{"top_left_x":180,"top_left_y":769,"width":1754,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fe082482c0c43fbb6b6b017cdf5e0d3","type":"text","conversion_output":true,"text":"21. 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