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performance in PAD:","confidence":0.998046875,"confidence_rate":0.9999767260466069},{"cnt":[[881,249],[1244,249],[1244,299],[881,299]],"region":{"top_left_x":880,"top_left_y":249,"width":364,"height":50},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9718b105929a488d8cba58953c3f528a","type":"text","conversion_output":true,"parent_id":"6aac6eb75d73411289beee10e1bc267c","text":"The PROPEL Study","text_display":" The PROPEL Study","confidence":1,"confidence_rate":1},{"cnt":[[662,296],[1463,296],[1463,342],[662,342]],"region":{"top_left_x":661,"top_left_y":296,"width":803,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2964a80dabba46c6ac8dbf1395b4afdd","type":"text","conversion_output":true,"parent_id":"6aac6eb75d73411289beee10e1bc267c","text":"Principal Investigator: Mary McDermott, MD","text_display":" \\\\ Principal Investigator: Mary McDermott, MD\n}","confidence":1,"confidence_rate":1},{"cnt":[[913,378],[1210,378],[1210,425],[913,425]],"region":{"top_left_x":913,"top_left_y":378,"width":297,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1bcffe5c5eaf4a48a9311366144677cf","type":"section_header","conversion_output":false,"children_ids":["aa4f2753c35b4733973cb9f34a560a7e"],"text":"","text_display":""},{"cnt":[[917,382],[1205,382],[1205,423],[917,423]],"region":{"top_left_x":917,"top_left_y":382,"width":289,"height":42},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa4f2753c35b4733973cb9f34a560a7e","type":"text","conversion_output":true,"parent_id":"1bcffe5c5eaf4a48a9311366144677cf","text":"SPECIFIC AIMS","text_display":"\n\n\\section*{SPECIFIC AIMS}","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1919,425],[1919,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1799,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c5da7ae139a4c7e80c7acb061c164e0","type":"text","conversion_output":true,"text":"Preliminary evidence suggests that increasing circulating levels of CD34+ cells with granulocyte monocyte","text_display":"\n\nPreliminary evidence suggests that increasing circulating levels of CD34+ cells with granulocyte monocyte","confidence":1,"confidence_rate":1},{"cnt":[[120,471],[1996,471],[1996,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1876,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c5827fe3bff4b55991af18e4d2982ed","type":"text","conversion_output":true,"text":"colony stimulating factor (GM-CSF) or other therapies may improve walking performance in patients with lower","text_display":" colony stimulating factor (GM-CSF) or other therapies may improve walking performance in patients with lower","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1970,516],[1970,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1851,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a931ef0b91f44a7baa53b7f69011fbab","type":"text","conversion_output":true,"text":"extremity peripheral arterial disease (PAD) \\((1,2)\\). However, results of small clinical trials are mixed (1-4). The","text_display":" extremity peripheral arterial disease (PAD) \\((1,2)\\). However, results of small clinical trials are mixed (1-4). The","confidence":0.925910375546664,"confidence_rate":0.9993692331508174},{"cnt":[[120,559],[1981,559],[1981,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1861,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5e9ff4665594786b60128203f49a7db","type":"text","conversion_output":true,"text":"association of GM-CSF with improved walking performance in PAD is not definitively established. Preliminary","text_display":" association of GM-CSF with improved walking performance in PAD is not definitively established. Preliminary","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,602],[1927,602],[1927,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1808,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b464ecc34014b49af6c4e2486655f0e","type":"text","conversion_output":true,"text":"data also suggest that lower extremity ischemia, induced during walking exercise, may increase circulating","text_display":" data also suggest that lower extremity ischemia, induced during walking exercise, may increase circulating","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1953,645],[1953,690],[120,690]],"region":{"top_left_x":120,"top_left_y":644,"width":1833,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b61ebdb061d5423b832338ceddc13db2","type":"text","conversion_output":true,"text":"CD34+ cell levels, enhance homing of CD34+ cells to ischemic sites, and augment the ability of GM-CSF to","text_display":" CD34+ cell levels, enhance homing of CD34+ cells to ischemic sites, and augment the ability of GM-CSF to","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1953,690],[1953,735],[120,735]],"region":{"top_left_x":120,"top_left_y":689,"width":1833,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a2c82b052784c599fea23a36c142d5b","type":"text","conversion_output":true,"text":"improve walking performance in PAD (1,2). We propose a randomized controlled clinical trial ( \\(2 \\times 2\\) factorial","text_display":" improve walking performance in PAD (1,2). We propose a randomized controlled clinical trial ( \\(2 \\times 2\\) factorial","confidence":0.4745070921187562,"confidence_rate":0.9935385419761945},{"cnt":[[120,735],[1858,735],[1858,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1739,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4cbeef48d2e43f8b7138f9ffb2a8028","type":"text","conversion_output":true,"text":"design) of 240 participants with PAD randomized to one of four arms: Group A: GM-CSF + supervised","text_display":" design) of 240 participants with PAD randomized to one of four arms: Group A: GM-CSF + supervised","confidence":0.92822265625,"confidence_rate":0.9992908835070607},{"cnt":[[120,778],[1910,778],[1910,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1790,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6eb73b3912fa45efa46a16a9adf0df1f","type":"text","conversion_output":true,"text":"exercise therapy; Group B: GM-CSF therapy + an attention control group; Group C: placebo + supervised","text_display":" exercise therapy; Group B: GM-CSF therapy + an attention control group; Group C: placebo + supervised","confidence":0.9415704540442675,"confidence_rate":0.9994321791770872},{"cnt":[[120,821],[1906,821],[1906,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1786,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ca48b709c814a32ba0722c84ef9dd9e","type":"text","conversion_output":true,"text":"exercise therapy; and Group D: placebo + attention control group. Our primary outcome is change in six-","text_display":" exercise therapy; and Group D: placebo + attention control group. Our primary outcome is change in six","confidence":0.518789529800415,"confidence_rate":0.9941052175116524},{"cnt":[[120,866],[1863,866],[1863,911],[120,911]],"region":{"top_left_x":120,"top_left_y":865,"width":1743,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6072802b246949ad80339323ab11f28e","type":"text","conversion_output":true,"text":"minute walk performance between baseline and 12 -week follow-up. From this point forward, \"GM-CSF","text_display":"minute walk performance between baseline and 12 -week follow-up. From this point forward, \"GM-CSF","confidence":0.98291015625,"confidence_rate":0.9998358462316606},{"cnt":[[120,907],[1944,907],[1944,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1825,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e2c5293887f42cfbb3e1adca29d3deb","type":"text","conversion_output":true,"text":"combined with supervised treadmill exercise\" refers to Group A; \"GM-CSF therapy alone\" refers to Group B,","text_display":" combined with supervised treadmill exercise\" refers to Group A; \"GM-CSF therapy alone\" refers to Group B,","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1742,954],[1742,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1623,"height":47},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1ed156a91124d3a831ddb6a8241d900","type":"text","conversion_output":true,"text":"\"supervised exercise therapy alone\" refers to Group C, and no active therapy refers to Group D.","text_display":" \"supervised exercise therapy alone\" refers to Group C, and no active therapy refers to Group D.","confidence":1,"confidence_rate":1},{"cnt":[[116,1036],[524,1036],[524,1089],[116,1089]],"region":{"top_left_x":116,"top_left_y":1035,"width":409,"height":55},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44fec07b40a14482822b8a01d0c1735c","type":"section_header","conversion_output":false,"children_ids":["7018483069df477ca348f2779c34cd66"],"text":"","text_display":""},{"cnt":[[120,1040],[520,1040],[520,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1039,"width":400,"height":49},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7018483069df477ca348f2779c34cd66","type":"text","conversion_output":true,"parent_id":"44fec07b40a14482822b8a01d0c1735c","text":"Primary Specific Aim.","text_display":"\n\n\\section*{Primary Specific Aim.}","confidence":0.763671875,"confidence_rate":0.9896836947892306},{"cnt":[[122,1085],[1888,1085],[1888,1132],[122,1132]],"region":{"top_left_x":122,"top_left_y":1084,"width":1767,"height":49},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"147640dc405646a0923c198c729d0811","type":"text","conversion_output":true,"text":"1. We will determine whether GM-CSF combined with supervised treadmill exercise (Group A) achieves","text_display":"\n1. We will determine whether GM-CSF combined with supervised treadmill exercise (Group A) achieves","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1880,1130],[1880,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1760,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d6e749879a94d679ebb0314ef687a98","type":"text","conversion_output":true,"text":"greater improvement in six-minute walk performance at 12 -week follow-up, compared to GM-CSF alone","text_display":" greater improvement in six-minute walk performance at 12 -week follow-up, compared to GM-CSF alone","confidence":0.98876953125,"confidence_rate":0.9998934584437023},{"cnt":[[120,1173],[1901,1173],[1901,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1782,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e76c571714f04883831ec384787e2b4d","type":"text","conversion_output":true,"text":"(Group B) and supervised exercise alone (Group C), respectively. We hypothesize that PAD participants","text_display":" (Group B) and supervised exercise alone (Group C), respectively. We hypothesize that PAD participants","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,1216],[2000,1216],[2000,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1881,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eeac390c9d5940608a65fc55199037fd","type":"text","conversion_output":true,"text":"randomized to Group A will achieve greater improvement in six-minute walk performance at 12-week follow-up,","text_display":" randomized to Group A will achieve greater improvement in six-minute walk performance at 12-week follow-up,","confidence":0.89306640625,"confidence_rate":0.9989907387741179},{"cnt":[[120,1307],[120,1259],[1669,1261],[1669,1309]],"region":{"top_left_x":120,"top_left_y":1258,"width":1550,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e295b2d2a87f4dda8757f0c131bbb2e0","type":"text","conversion_output":true,"text":"compared to those randomized to Group B and those randomized to Group C, respectively.","text_display":" compared to those randomized to Group B and those randomized to Group C, respectively.","confidence":0.63720703125,"confidence_rate":0.9950599274786927},{"cnt":[[120,1302],[1850,1302],[1850,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1730,"height":51},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b71f0fe2e124a09977c27a7c369074b","type":"text","conversion_output":true,"text":"2. We will determine whether GM-CSF therapy alone (Group B) significantly improves six-minute walk","text_display":"\n2. We will determine whether GM-CSF therapy alone (Group B) significantly improves six-minute walk","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1979,1349],[1979,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1859,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5031e62151944aa48b1b5ac606b79bb0","type":"text","conversion_output":true,"text":"performance at 12 -week follow-up, compared to Group D. We hypothesize that PAD participants randomized","text_display":" performance at 12 -week follow-up, compared to Group D. We hypothesize that PAD participants randomized","confidence":0.8540841275254252,"confidence_rate":0.9985800579013783},{"cnt":[[120,1392],[1869,1392],[1869,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1750,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db39cd8e630449c588537df63ac2444f","type":"text","conversion_output":true,"text":"to Group B will achieve greater improvement in the six-minute walk at 12-week follow-up than Group D.","text_display":" to Group B will achieve greater improvement in the six-minute walk at 12-week follow-up than Group D.","confidence":0.5472785893186938,"confidence_rate":0.9943293720504972},{"cnt":[[120,1435],[1893,1435],[1893,1482],[120,1482]],"region":{"top_left_x":120,"top_left_y":1435,"width":1773,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"368597cd69474a2d9dcae6ab42721d9b","type":"text","conversion_output":true,"text":"3. We will confirm that supervised treadmill exercise therapy alone (Group C) significantly increases six-","text_display":"\n3. We will confirm that supervised treadmill exercise therapy alone (Group C) significantly increases six","confidence":0.7357370853424072,"confidence_rate":0.9972391115696034},{"cnt":[[120,1480],[1970,1480],[1970,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1851,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd2b546031d24c1aa791e395fdc27989","type":"text","conversion_output":true,"text":"minute walk performance at 12 -week follow-up, compared to Group D. We hypothesize that PAD participants","text_display":"minute walk performance at 12 -week follow-up, compared to Group D. We hypothesize that PAD participants","confidence":0.5611884593963623,"confidence_rate":0.9948552574768179},{"cnt":[[120,1525],[2002,1525],[2002,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":1883,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0934ad9d3a8743ac9dfcd003ab202dda","type":"text","conversion_output":true,"text":"randomized to Group C will achieve greater improvement in six-minute walk performance at 12-week follow-up,","text_display":" randomized to Group C will achieve greater improvement in six-minute walk performance at 12-week follow-up,","confidence":0.9902582168579102,"confidence_rate":0.9999125971702655},{"cnt":[[120,1568],[862,1568],[862,1618],[120,1618]],"region":{"top_left_x":120,"top_left_y":1568,"width":742,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"423c972b223b42f19e176e49c1d922b6","type":"text","conversion_output":true,"text":"compared to those randomized to Group D.","text_display":" compared to those randomized to Group D.","confidence":1,"confidence_rate":1},{"cnt":[[116,1652],[578,1652],[578,1706],[116,1706]],"region":{"top_left_x":116,"top_left_y":1652,"width":462,"height":54},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"805e25547bc8475086ddd2317bbf0f8b","type":"section_header","conversion_output":false,"children_ids":["02a81186b83d4d7cbe04414d5c45929c"],"text":"","text_display":""},{"cnt":[[120,1659],[574,1659],[574,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1658,"width":454,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02a81186b83d4d7cbe04414d5c45929c","type":"text","conversion_output":true,"parent_id":"805e25547bc8475086ddd2317bbf0f8b","text":"Secondary Specific Aim.","text_display":"\n\n\\section*{Secondary Specific Aim.}","confidence":0.9990234375,"confidence_rate":0.9999651063356614},{"cnt":[[120,1697],[1884,1697],[1884,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1765,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f572b463f22489381f1db094bd4c22e","type":"text","conversion_output":true,"text":"1. We will determine whether GM-CSF combined with supervised exercise (Group A) is associated with","text_display":"\n1. We will determine whether GM-CSF combined with supervised exercise (Group A) is associated with","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[120,1745],[1929,1745],[1929,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1810,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b24b7a65761c41a4b3104bee53b8c140","type":"text","conversion_output":true,"text":"greater increases in brachial artery flow-mediated dilation (FMD) and maximal treadmill walking time at 12 -","text_display":" greater increases in brachial artery flow-mediated dilation (FMD) and maximal treadmill walking time at 12 ","confidence":0.7369892047718167,"confidence_rate":0.9973725781236586},{"cnt":[[120,1788],[1998,1788],[1998,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1879,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46e03d6f343d48c09db5fc8caeeb51a2","type":"text","conversion_output":true,"text":"week follow-up, compared to GM-CSF alone (Group B) and supervised exercise alone (Group C), respectively.","text_display":"week follow-up, compared to GM-CSF alone (Group B) and supervised exercise alone (Group C), respectively.","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1938,1830],[1938,1878],[120,1878]],"region":{"top_left_x":120,"top_left_y":1830,"width":1818,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f617ab6414834d338d17a096f4f267da","type":"text","conversion_output":true,"text":"2. We will determine whether GM-CSF alone (Group B) is associated with significantly greater increases in","text_display":"\n2. We will determine whether GM-CSF alone (Group B) is associated with significantly greater increases in","confidence":0.99658203125,"confidence_rate":0.9999688748175845},{"cnt":[[120,1876],[1828,1876],[1828,1921],[120,1921]],"region":{"top_left_x":120,"top_left_y":1875,"width":1709,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53dc9b12e02b44b1a21c5b16129a2bb6","type":"text","conversion_output":true,"text":"brachial artery FMD and maximal treadmill walking time at 12 -week follow-up, compared to Group D.","text_display":" brachial artery FMD and maximal treadmill walking time at 12 -week follow-up, compared to Group D.","confidence":1,"confidence_rate":1},{"cnt":[[120,1919],[1970,1919],[1970,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1851,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37924240dd1d413e857bc7889921dc39","type":"text","conversion_output":true,"text":"3. We will determine whether a supervised treadmill exercise intervention alone (Group C ) is associated with","text_display":"\n3. We will determine whether a supervised treadmill exercise intervention alone (Group C ) is associated with","confidence":0.83544921875,"confidence_rate":0.9985029074938209},{"cnt":[[120,1964],[1442,1964],[1442,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1322,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44368354cea04ba0ae217e9ca5af01c9","type":"text","conversion_output":true,"text":"greater increases in CD34+ cells at 12 -week follow-up, compared to Group D.","text_display":" greater increases in CD34+ cells at 12 -week follow-up, compared to Group D.","confidence":0.8581161499023438,"confidence_rate":0.9981800412821227},{"cnt":[[120,2007],[1957,2007],[1957,2054],[120,2054]],"region":{"top_left_x":120,"top_left_y":2006,"width":1838,"height":48},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"677fea490f62481089c986e3d8c40fac","type":"text","conversion_output":true,"text":"4. We will confirm prior data demonstrating that supervised treadmill exercise alone (Group C ) is associated","text_display":"\n4. We will confirm prior data demonstrating that supervised treadmill exercise alone (Group C ) is associated","confidence":0.951171875,"confidence_rate":0.9995829161540191},{"cnt":[[120,2050],[1893,2050],[1893,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2049,"width":1773,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b228d5af7b354f16a0af141d30b55578","type":"text","conversion_output":true,"text":"with greater increases in brachial artery FMD and maximal treadmill walking time, compared to Group D.","text_display":" with greater increases in brachial artery FMD and maximal treadmill walking time, compared to Group D.","confidence":0.99072265625,"confidence_rate":0.9999128949496261},{"cnt":[[122,2140],[1919,2140],[1919,2185],[122,2185]],"region":{"top_left_x":122,"top_left_y":2139,"width":1797,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fab5410365c428f9deff3b751334588","type":"text","conversion_output":true,"text":"In our Exploratory Aim, we will establish the temporal trajectory of favorable changes in study outcomes in","text_display":"\n\nIn our Exploratory Aim, we will establish the temporal trajectory of favorable changes in study outcomes in","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1927,2183],[1927,2230],[120,2230]],"region":{"top_left_x":120,"top_left_y":2182,"width":1808,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"68aa04f9c9524e4ab3142072f170baed","type":"text","conversion_output":true,"text":"response to GM-CSF. \"Study outcomes\" refers to six-minute walk performance, maximal treadmill walking","text_display":" response to GM-CSF. \"Study outcomes\" refers to six-minute walk performance, maximal treadmill walking","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1987,2226],[1987,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2225,"width":1868,"height":49},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc91a605758f4dd8be8ae2a35f0a004b","type":"text","conversion_output":true,"text":"time, and brachial artery FMD. We will also establish the temporal trajectory of increases in progenitor cells in","text_display":" time, and brachial artery FMD. We will also establish the temporal trajectory of increases in progenitor cells in","confidence":0.99755859375,"confidence_rate":0.9999792850336954},{"cnt":[[120,2271],[1927,2271],[1927,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1808,"height":47},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b240bc4fea154176b621d9a9c06a6bfe","type":"text","conversion_output":true,"text":"response to supervised treadmill exercise. We will determine whether the degree of increase in progenitor","text_display":" response to supervised treadmill exercise. We will determine whether the degree of increase in progenitor","confidence":1,"confidence_rate":1},{"cnt":[[120,2314],[1311,2314],[1311,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2313,"width":1191,"height":49},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb41c8cbabd74a0590a982df33f8b6fc","type":"text","conversion_output":true,"text":"cells is associated with the degree of improvement in study outcomes.","text_display":" cells is associated with the degree of improvement in study outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[116,2398],[617,2398],[617,2451],[116,2451]],"region":{"top_left_x":116,"top_left_y":2397,"width":501,"height":55},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3069d0f0f68f45e692b424590c1603bb","type":"section_header","conversion_output":false,"children_ids":["85e3786cfcb24670bb5b357a673eead0"],"text":"","text_display":""},{"cnt":[[122,2402],[612,2402],[612,2447],[122,2447]],"region":{"top_left_x":122,"top_left_y":2401,"width":491,"height":47},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85e3786cfcb24670bb5b357a673eead0","type":"text","conversion_output":true,"parent_id":"3069d0f0f68f45e692b424590c1603bb","text":"Exploratory Specific Aims.","text_display":"\n\n\\section*{Exploratory Specific Aims.}","confidence":1,"confidence_rate":1},{"cnt":[[122,2445],[1906,2445],[1906,2494],[122,2494]],"region":{"top_left_x":122,"top_left_y":2444,"width":1784,"height":51},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b752b511dc7c409d9be1e99eaf8969ae","type":"text","conversion_output":true,"text":"1. We will determine whether GM-CSF combined with supervised treadmill exercise therapy (Group A) is","text_display":"\n1. We will determine whether GM-CSF combined with supervised treadmill exercise therapy (Group A) is","confidence":1,"confidence_rate":1},{"cnt":[[120,2490],[1846,2490],[1846,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2490,"width":1726,"height":48},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5805a90ab7ed4ae78cb6dbcc6cb147a4","type":"text","conversion_output":true,"text":"associated with greater increases in study outcomes at six-week follow-up and at six-month follow-up,","text_display":" associated with greater increases in study outcomes at six-week follow-up and at six-month follow-up,","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,2535],[2000,2535],[2000,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2535,"width":1881,"height":46},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"474db9b9302944e1b2c8a6aa44fdcaed","type":"text","conversion_output":true,"text":"compared to GM-CSF therapy alone (Group B) and supervised exercise therapy alone (Group C), respectively.","text_display":" compared to GM-CSF therapy alone (Group B) and supervised exercise therapy alone (Group C), respectively.","confidence":1,"confidence_rate":1},{"cnt":[[1053,2582],[1074,2582],[1074,2628],[1053,2628]],"region":{"top_left_x":1052,"top_left_y":2582,"width":23,"height":46},"line":57,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ede9c82058e4e5c80e21d3b3922a1e2","type":"page_info","conversion_output":false,"text":"1","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-02","page":2,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ee1f70401f1e4104a6e2c3259c5add31","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,165],[1738,165]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1eba578780534376af4520182910001c","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1833,206],[1833,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1713,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"706b6836d244438c9efafab3a6a871ee","type":"text","conversion_output":true,"text":"2. We will determine whether GM-CSF alone (Group B) is associated with greater increases in study","text_display":"\n2. We will determine whether GM-CSF alone (Group B) is associated with greater increases in study","confidence":0.91650390625,"confidence_rate":0.9991455716087322},{"cnt":[[120,249],[1738,249],[1738,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1619,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e27f43ff4804083b3d696b962bb449b","type":"text","conversion_output":true,"text":"outcomes at six-week follow-up and at six-month follow-up, respectively, compared to Group D.","text_display":" outcomes at six-week follow-up and at six-month follow-up, respectively, compared to Group D.","confidence":1,"confidence_rate":1},{"cnt":[[120,294],[1919,294],[1919,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1799,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6a324ad505b4f158a2478bebd6a17e7","type":"text","conversion_output":true,"text":"3. We will determine whether supervised exercise therapy alone (Group C) is associated with significantly","text_display":"\n3. We will determine whether supervised exercise therapy alone (Group C) is associated with significantly","confidence":0.9048771858215332,"confidence_rate":0.9990917213643806},{"cnt":[[120,339],[1996,339],[1996,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1876,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26f3f2ff82334127aead51356608d0e5","type":"text","conversion_output":true,"text":"greater increases in CD34+ cells and other progenitor cell measures at two-week follow-up, six-week follow-up","text_display":" greater increases in CD34+ cells and other progenitor cell measures at two-week follow-up, six-week follow-up","confidence":0.9970703125,"confidence_rate":0.9999742635993027},{"cnt":[[120,382],[973,382],[973,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":854,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"313067d90b904207add8684ad06db565","type":"text","conversion_output":true,"text":"and at six-month follow-up, compared to Group D.","text_display":" and at six-month follow-up, compared to Group D.","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1979,425],[1979,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1859,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de153932072d480ab04e999312d4f6fd","type":"text","conversion_output":true,"text":"4. Among participants receiving GM-CSF, we will determine whether the degree of increase in progenitor cell","text_display":"\n4. Among participants receiving GM-CSF, we will determine whether the degree of increase in progenitor cell","confidence":1,"confidence_rate":1},{"cnt":[[120,473],[1996,473],[1996,518],[120,518]],"region":{"top_left_x":120,"top_left_y":472,"width":1876,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6eadb5f90e6144c7b8f1989b94bdbcb4","type":"text","conversion_output":true,"text":"measures at two-week follow-up is associated with the degree of improvement in remaining study outcomes at","text_display":" measures at two-week follow-up is associated with the degree of improvement in remaining study outcomes at","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1102,516],[1102,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":983,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2985ea709f6f4c379827cf91e282d35a","type":"text","conversion_output":true,"text":"six-week, 12 -week, and six-month follow-up, respectively.","text_display":" six-week, 12 -week, and six-month follow-up, respectively.","confidence":0.9795112609863281,"confidence_rate":0.9996863894134231},{"cnt":[[120,559],[2000,559],[2000,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1881,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d75e6e57a184aa7985b2b2039a747cb","type":"text","conversion_output":true,"text":"5. Among up to 30 participants with PAD and 15 consenting participants who are determined not to have PAD,","text_display":"\n5. Among up to 30 participants with PAD and 15 consenting participants who are determined not to have PAD,","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1897,602],[1897,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1778,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25d812c4d39f4d218945309aef7ea680","type":"text","conversion_output":true,"text":"we will determine whether progenitor cell measures increase acutely after a treadmill exercise stress test","text_display":" we will determine whether progenitor cell measures increase acutely after a treadmill exercise stress test","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1972,645],[1972,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1853,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a94352fec3fc43809e24c065c7c229f2","type":"text","conversion_output":true,"text":"among participants with PAD and among those without PAD, respectively. We will further determine whether","text_display":" among participants with PAD and among those without PAD, respectively. We will further determine whether","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1953,690],[1953,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1833,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03fa3698ee174a81acb20760590f1d38","type":"text","conversion_output":true,"text":"greater increases in progenitor cell measures after a treadmill exercise stress test are associated with better","text_display":" greater increases in progenitor cell measures after a treadmill exercise stress test are associated with better","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[120,735],[1940,735],[1940,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1821,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ce4ec106bf9464c81e419242aa3b283","type":"text","conversion_output":true,"text":"six-minute walk performance and higher ABI values at baseline, compared to lesser increases in progenitor","text_display":" six-minute walk performance and higher ABI values at baseline, compared to lesser increases in progenitor","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[986,778],[986,819],[120,819]],"region":{"top_left_x":120,"top_left_y":777,"width":867,"height":42},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ade9e1200db34ad9987213694d51b93d","type":"text","conversion_output":true,"text":"cell measures after a treadmill exercise stress test.","text_display":" cell measures after a treadmill exercise stress test.","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1972,821],[1972,868],[120,868]],"region":{"top_left_x":120,"top_left_y":820,"width":1853,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e66c829f0814e8bb1a922500110198a","type":"text","conversion_output":true,"text":"6. Study participants will have the option of participating in a sub study that consists of a muscle biopsy of the","text_display":"\n6. Study participants will have the option of participating in a sub study that consists of a muscle biopsy of the","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[120,866],[1962,866],[1962,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1842,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3902dd1f37f0420e83477bbe5ea28c00","type":"text","conversion_output":true,"text":"medial head of the gastrocnemius muscle. The muscle biopsy will be performed by Dr. Robert Sufit, a board","text_display":" medial head of the gastrocnemius muscle. The muscle biopsy will be performed by Dr. Robert Sufit, a board","confidence":1,"confidence_rate":1},{"cnt":[[120,911],[1962,911],[1962,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1842,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2404c9e92b6f40ae85072410e078e9a9","type":"text","conversion_output":true,"text":"certified neurologist with more than 20 years of experience performing lower extremity muscle biopsies. The","text_display":" certified neurologist with more than 20 years of experience performing lower extremity muscle biopsies. The","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1790,954],[1790,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1670,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8df21628b2194d7e8c4b8e14c8498839","type":"text","conversion_output":true,"text":"muscle biopsy will be performed in a clinical examination room using an open biopsy technique. A","text_display":" muscle biopsy will be performed in a clinical examination room using an open biopsy technique. A","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1927,997],[1927,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1808,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1a64057d0bb4dd881358d62312eac23","type":"text","conversion_output":true,"text":"subcutaneous injection of lidocaine will be administered. For the lower extremity biopsy, an incision will be","text_display":" subcutaneous injection of lidocaine will be administered. For the lower extremity biopsy, an incision will be","confidence":1,"confidence_rate":1},{"cnt":[[120,1042],[1981,1042],[1981,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1041,"width":1861,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd2a33930ce7491192cb6165ac56c376","type":"text","conversion_output":true,"text":"made in the lower extremity muscle (medial head of the gastrocnemius muscle and approximately 250 mgs of","text_display":" made in the lower extremity muscle (medial head of the gastrocnemius muscle and approximately 250 mgs of","confidence":1,"confidence_rate":1},{"cnt":[[120,1087],[1895,1087],[1895,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1775,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6522db83e84445ebf83d11754f87846","type":"text","conversion_output":true,"text":"muscle tissue will be removed. Most or all of the sample will be frozen immediately in liquid nitrogen and","text_display":" muscle tissue will be removed. Most or all of the sample will be frozen immediately in liquid nitrogen and","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1962,1130],[1962,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1842,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e57520e816b94feba1aee1115bb95878","type":"text","conversion_output":true,"text":"stored at - 80 degrees Celsius. Participants will be asked to return for a follow-up visit to check the site of the","text_display":" stored at - 80 degrees Celsius. Participants will be asked to return for a follow-up visit to check the site of the","confidence":0.4217491149902344,"confidence_rate":0.9930055138396727},{"cnt":[[120,1173],[1985,1173],[1985,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1866,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"954050405eef43f093b875bc509650af","type":"text","conversion_output":true,"text":"muscle biopsy approximately one week after the procedure. Participants may be asked to undergo a muscle","text_display":" muscle biopsy approximately one week after the procedure. Participants may be asked to undergo a muscle","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[1955,1216],[1955,1261],[120,1261]],"region":{"top_left_x":120,"top_left_y":1216,"width":1836,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9518d313ef2340ad925d721873b09f0b","type":"text","conversion_output":true,"text":"biopsy at baseline and after 26 -week follow-up. Thus, the total number of muscle biopsies a participant may","text_display":" biopsy at baseline and after 26 -week follow-up. Thus, the total number of muscle biopsies a participant may","confidence":0.97705078125,"confidence_rate":0.9997998764793177},{"cnt":[[120,1261],[1987,1261],[1987,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1261,"width":1868,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73146d316ec4422cb319abd07d3f8b30","type":"text","conversion_output":true,"text":"be asked to have is two (one lower extremity biopsy at baseline and one at six-month follow-up). We may take","text_display":" be asked to have is two (one lower extremity biopsy at baseline and one at six-month follow-up). We may take","confidence":1,"confidence_rate":1},{"cnt":[[120,1304],[1854,1304],[1854,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1304,"width":1735,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75b47a7a9ed0485d8f753fc023f080c1","type":"text","conversion_output":true,"text":"photographs of the biopsy site and biopsy tissue before, during, and after the procedure. We may take","text_display":" photographs of the biopsy site and biopsy tissue before, during, and after the procedure. We may take","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1972,1349],[1972,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1853,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d95198ca41b4a2da5da02a391440f23","type":"text","conversion_output":true,"text":"photographs at the post-biopsy incision check-up as well to show the scar and healing. These images will not","text_display":" photographs at the post-biopsy incision check-up as well to show the scar and healing. These images will not","confidence":0.99853515625,"confidence_rate":0.9999870273612914},{"cnt":[[120,1392],[1824,1392],[1824,1439],[120,1439]],"region":{"top_left_x":120,"top_left_y":1392,"width":1705,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bbe6c8b1e592433691fcc6699eedc36b","type":"text","conversion_output":true,"text":"show any identifying information such as name or date of birth. These images may be used for grant","text_display":" show any identifying information such as name or date of birth. These images may be used for grant","confidence":1,"confidence_rate":1},{"cnt":[[120,1439],[1981,1439],[1981,1485],[120,1485]],"region":{"top_left_x":120,"top_left_y":1439,"width":1861,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7702e58f4c24a27b5bea41ad2bd51e6","type":"text","conversion_output":true,"text":"proposals, manuscripts, or other research related activities. Muscle specimens will be sent to the Universities","text_display":" proposals, manuscripts, or other research related activities. Muscle specimens will be sent to the Universities","confidence":1,"confidence_rate":1},{"cnt":[[120,1485],[1867,1485],[1867,1532],[120,1532]],"region":{"top_left_x":120,"top_left_y":1484,"width":1747,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fb360fa33a7458eb9c7e7873c9f94d8","type":"text","conversion_output":true,"text":"of Florida and Kentucky for analyses that include inflammatory biomarkers, markers of oxidative stress,","text_display":" of Florida and Kentucky for analyses that include inflammatory biomarkers, markers of oxidative stress,","confidence":1,"confidence_rate":1},{"cnt":[[120,1530],[1989,1530],[1989,1575],[120,1575]],"region":{"top_left_x":120,"top_left_y":1529,"width":1870,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c0a60389aaf4b0ab4444348727ef888","type":"text","conversion_output":true,"text":"measures of mitochondrial function and quantity, and muscle myofiber typing. Analyses may also be tested for","text_display":" measures of mitochondrial function and quantity, and muscle myofiber typing. Analyses may also be tested for","confidence":1,"confidence_rate":1},{"cnt":[[120,1573],[1927,1573],[1927,1618],[120,1618]],"region":{"top_left_x":120,"top_left_y":1572,"width":1808,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce8eb4f7f39e44f5b36b6e0f3e0a2d94","type":"text","conversion_output":true,"text":"protein measures of mitochondrial function, macrophages, satellite cells, and PCR/gene expression. Other","text_display":" protein measures of mitochondrial function, macrophages, satellite cells, and PCR/gene expression. Other","confidence":1,"confidence_rate":1},{"cnt":[[120,1616],[1489,1616],[1489,1663],[120,1663]],"region":{"top_left_x":120,"top_left_y":1615,"width":1369,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5257d308a464c76ab9ab2ab79df22f6","type":"text","conversion_output":true,"text":"measures related to skeletal muscle quality and function may also be performed.","text_display":" measures related to skeletal muscle quality and function may also be performed.","confidence":1,"confidence_rate":1},{"cnt":[[120,1704],[1790,1704],[1790,1749],[120,1749]],"region":{"top_left_x":120,"top_left_y":1703,"width":1670,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e7918603b4c4d028da364000451cb8d","type":"text","conversion_output":true,"text":"In addition, in a subset of participants we will obtain a muscle biopsy from the left and the right leg,","text_display":"\n\nIn addition, in a subset of participants we will obtain a muscle biopsy from the left and the right leg,","confidence":1,"confidence_rate":1},{"cnt":[[120,1749],[1910,1749],[1910,1794],[120,1794]],"region":{"top_left_x":120,"top_left_y":1748,"width":1790,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e905318b60ab48c28d3e9e4564daf030","type":"text","conversion_output":true,"text":"respectively. These bilateral biopsies could be obtained at baseline, at 26-week follow-up, or at both time","text_display":" respectively. These bilateral biopsies could be obtained at baseline, at 26-week follow-up, or at both time","confidence":0.810546875,"confidence_rate":0.9981263458355086},{"cnt":[[120,1792],[1927,1792],[1927,1837],[120,1837]],"region":{"top_left_x":120,"top_left_y":1791,"width":1808,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cce58f06e7d7479ba2d98e1158ba056d","type":"text","conversion_output":true,"text":"points. The second (contralateral) biopsy will be performed at least six days after the first biopsy. In some","text_display":" points. The second (contralateral) biopsy will be performed at least six days after the first biopsy. In some","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[120,1835],[1992,1835],[1992,1880],[120,1880]],"region":{"top_left_x":120,"top_left_y":1834,"width":1872,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3551622043944388bd80a24bdba8dbf5","type":"text","conversion_output":true,"text":"cases, the second biopsy may take place when the participant returns for their incision site check after the first","text_display":" cases, the second biopsy may take place when the participant returns for their incision site check after the first","confidence":1,"confidence_rate":1},{"cnt":[[120,1878],[1938,1878],[1938,1927],[120,1927]],"region":{"top_left_x":120,"top_left_y":1877,"width":1818,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"068f264b1f6c44eb889cfa3a186d751a","type":"text","conversion_output":true,"text":"biopsy. It will be necessary for these individuals to remain off of their anti-platelet therapy for 7 days before","text_display":" biopsy. It will be necessary for these individuals to remain off of their anti-platelet therapy for 7 days before","confidence":0.99755859375,"confidence_rate":0.9999797986227136},{"cnt":[[120,1923],[1953,1923],[1953,1970],[120,1970]],"region":{"top_left_x":120,"top_left_y":1922,"width":1833,"height":49},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73b45d058484401982ad993b245d4b55","type":"text","conversion_output":true,"text":"each procedure (i.e. potentially for approximately 14 days continuously). Physician approval will be required.","text_display":" each procedure (i.e. potentially for approximately 14 days continuously). Physician approval will be required.","confidence":0.9990234375,"confidence_rate":0.9999917200372636},{"cnt":[[116,2007],[913,2007],[913,2056],[116,2056]],"region":{"top_left_x":116,"top_left_y":2006,"width":798,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c50ff5f7681440e0bbeeb08e2cd8acc7","type":"section_header","conversion_output":false,"children_ids":["476cfca32175475eb102d7e486173e91"],"text":"","text_display":""},{"cnt":[[120,2011],[909,2011],[909,2052],[120,2052]],"region":{"top_left_x":120,"top_left_y":2010,"width":789,"height":42},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"476cfca32175475eb102d7e486173e91","type":"text","conversion_output":true,"parent_id":"c50ff5f7681440e0bbeeb08e2cd8acc7","text":"A. RESEARCH STRATEGY- SIGNIFICANCE","text_display":"\n\n\\section*{A. RESEARCH STRATEGY- SIGNIFICANCE}","confidence":0.99951171875,"confidence_rate":0.9999874769887185},{"cnt":[[120,2054],[1927,2054],[1927,2103],[120,2103]],"region":{"top_left_x":120,"top_left_y":2053,"width":1808,"height":51},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33a179ccc9d944bfaed39695eacd252d","type":"text","conversion_output":true,"text":"A1. Lower extremity peripheral arterial disease (PAD) is common and is associated with functional","text_display":"\n\nA1. Lower extremity peripheral arterial disease (PAD) is common and is associated with functional","confidence":1,"confidence_rate":1},{"cnt":[[120,2099],[1996,2097],[1996,2144],[120,2146]],"region":{"top_left_x":120,"top_left_y":2096,"width":1876,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2585e98077d741e59ffc316bdd9e314b","type":"text","conversion_output":true,"text":"impairment and functional decline. PAD affects eight million men and women in the United States, and will","text_display":" impairment and functional decline. PAD affects eight million men and women in the United States, and will","confidence":1,"confidence_rate":1},{"cnt":[[120,2144],[2000,2144],[2000,2189],[120,2189]],"region":{"top_left_x":120,"top_left_y":2144,"width":1881,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ff1e472ab6146fabda077f7fb8bc686","type":"text","conversion_output":true,"text":"be increasingly prevalent as the U.S. population survives longer with chronic disease (5). Our work and that of","text_display":" be increasingly prevalent as the U.S. population survives longer with chronic disease (5). Our work and that of","confidence":0.90576171875,"confidence_rate":0.9991470965918344},{"cnt":[[120,2187],[1880,2187],[1880,2232],[120,2232]],"region":{"top_left_x":120,"top_left_y":2187,"width":1760,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ea667b5d7414519aa69e47a67c73eed","type":"text","conversion_output":true,"text":"others demonstrates that men and women with PAD have greater functional impairment and more rapid","text_display":" others demonstrates that men and women with PAD have greater functional impairment and more rapid","confidence":1,"confidence_rate":1},{"cnt":[[120,2230],[1854,2230],[1854,2275],[120,2275]],"region":{"top_left_x":120,"top_left_y":2230,"width":1735,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6331fd79a61742288eae3fa851b0ab49","type":"text","conversion_output":true,"text":"functional decline than those without PAD (6-10). The functional impairments documented in PAD are","text_display":" functional decline than those without PAD (6-10). The functional impairments documented in PAD are","confidence":1,"confidence_rate":1},{"cnt":[[120,2273],[1644,2273],[1644,2322],[120,2322]],"region":{"top_left_x":120,"top_left_y":2273,"width":1524,"height":50},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e656c71544d489cb4b198bc8df78780","type":"text","conversion_output":true,"text":"associated with loss of independence, increased mortality, and poor quality of life (11-13).","text_display":" associated with loss of independence, increased mortality, and poor quality of life (11-13).","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[120,2361],[1962,2361],[1962,2408],[120,2408]],"region":{"top_left_x":120,"top_left_y":2361,"width":1842,"height":48},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0da83af7db35461a85b99f3bc8e98a5e","type":"text","conversion_output":true,"text":"A2. Few medical therapies have been identified that improve functional impairment in PAD. Only two","text_display":"\n\nA2. Few medical therapies have been identified that improve functional impairment in PAD. Only two","confidence":0.99951171875,"confidence_rate":0.9999952582588333},{"cnt":[[120,2406],[1979,2406],[1979,2451],[120,2451]],"region":{"top_left_x":120,"top_left_y":2406,"width":1859,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9af444f494924460b6e61acaa1c9582f","type":"text","conversion_output":true,"text":"medications, pentoxifylline and cilostazol, are FDA-approved for treating PAD-associated walking impairment.","text_display":" medications, pentoxifylline and cilostazol, are FDA-approved for treating PAD-associated walking impairment.","confidence":1,"confidence_rate":1},{"cnt":[[120,2449],[1953,2449],[1953,2496],[120,2496]],"region":{"top_left_x":120,"top_left_y":2449,"width":1833,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e99c3dd48654bc3b0b93e77ef21ee05","type":"text","conversion_output":true,"text":"Of these, pentoxifylline is usually ineffective and benefits from cilostazol are modest (14-17). New therapies","text_display":" Of these, pentoxifylline is usually ineffective and benefits from cilostazol are modest (14-17). New therapies","confidence":1,"confidence_rate":1},{"cnt":[[120,2494],[1901,2494],[1901,2539],[120,2539]],"region":{"top_left_x":120,"top_left_y":2494,"width":1782,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65281c19afb14f9486c5b5c638d90476","type":"text","conversion_output":true,"text":"are urgently needed to improve walking performance and prevent functional decline in patients with PAD.","text_display":" are urgently needed to improve walking performance and prevent functional decline in patients with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[1048,2582],[1079,2582],[1079,2628],[1048,2628]],"region":{"top_left_x":1048,"top_left_y":2582,"width":31,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"841a420ebd36474da00b9f03ae19a540","type":"page_info","conversion_output":false,"text":"2","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-03","page":3,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd7b2da4416c47acb93ed69fa519d4e2","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,165],[1740,165]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89c6741f95074328babf6a085c035965","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[1936,249],[1936,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1816,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5569cfdfe0b0478381877b2880aaca3a","type":"text","conversion_output":true,"text":"A3. Interventions that increase circulating progenitor cells are among the most promising emerging","text_display":"\n\nA3. Interventions that increase circulating progenitor cells are among the most promising emerging","confidence":1,"confidence_rate":1},{"cnt":[[120,296],[1970,296],[1970,342],[120,342]],"region":{"top_left_x":120,"top_left_y":296,"width":1851,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"554c5256d0ba458b85cfb22d5386beff","type":"text","conversion_output":true,"text":"therapies for patients with cardiovascular disease. Progenitor cells normally exist in low concentrations in","text_display":" therapies for patients with cardiovascular disease. Progenitor cells normally exist in low concentrations in","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1906,339],[1906,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1786,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5ac89e01fb64df28ef44f857522daea","type":"text","conversion_output":true,"text":"peripheral blood. Interventions, such as GM-CSF, promote release of progenitor cells from bone marrow,","text_display":" peripheral blood. Interventions, such as GM-CSF, promote release of progenitor cells from bone marrow,","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[1966,382],[1966,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1846,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2086438e6521461e94c98a31a2f26630","type":"text","conversion_output":true,"text":"spleen, and other sources into the circulation (18-20). These circulating progenitor cells can differentiate into","text_display":" spleen, and other sources into the circulation (18-20). These circulating progenitor cells can differentiate into","confidence":1,"confidence_rate":1},{"cnt":[[120,427],[1983,425],[1983,471],[120,473]],"region":{"top_left_x":120,"top_left_y":424,"width":1864,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5382ca008aa34ff68b58f2729a920a5e","type":"text","conversion_output":true,"text":"mature endothelial cells and form new blood vessels, termed neoangiogenesis (21-24). In 1997, Asahara and","text_display":" mature endothelial cells and form new blood vessels, termed neoangiogenesis (21-24). In 1997, Asahara and","confidence":1,"confidence_rate":1},{"cnt":[[120,473],[1953,473],[1953,518],[120,518]],"region":{"top_left_x":120,"top_left_y":472,"width":1833,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2374cc4c46264ef88271005af9590b8c","type":"text","conversion_output":true,"text":"colleagues demonstrated that CD34+ progenitor cells isolated from human peripheral blood differentiate into","text_display":" colleagues demonstrated that CD34+ progenitor cells isolated from human peripheral blood differentiate into","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1846,516],[1846,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1726,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e01bad4599c480e80943ed0b9d4f17f","type":"text","conversion_output":true,"text":"mature endothelial cells in vitro (22). In a rabbit hind limb ischemia model, these isolated CD34+ cells","text_display":" mature endothelial cells in vitro (22). In a rabbit hind limb ischemia model, these isolated CD34+ cells","confidence":0.9819421768188477,"confidence_rate":0.999832831814178},{"cnt":[[120,559],[1807,559],[1807,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1687,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afcf93c5f2fb4b9ea0a795fbeb314268","type":"text","conversion_output":true,"text":"migrated to sites of tissue ischemia and incorporated into developing blood vessels (22). This work","text_display":" migrated to sites of tissue ischemia and incorporated into developing blood vessels (22). This work","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1989,602],[1989,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1870,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35a10e63b4794fda83204472bac8b515","type":"text","conversion_output":true,"text":"established that circulating progenitor cells isolated from humans can differentiate into mature endothelial cells","text_display":" established that circulating progenitor cells isolated from humans can differentiate into mature endothelial cells","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1987,645],[1987,690],[120,690]],"region":{"top_left_x":120,"top_left_y":644,"width":1868,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c08b3d39998c4ba79208dffbd7466360","type":"text","conversion_output":true,"text":"and promote new blood vessel development in vivo. Progenitor cells also repair endothelial-cell injury and are","text_display":" and promote new blood vessel development in vivo. Progenitor cells also repair endothelial-cell injury and are","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1833,690],[1833,735],[120,735]],"region":{"top_left_x":120,"top_left_y":689,"width":1713,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a39c45ca2ed4912a0d45a7120f15985","type":"text","conversion_output":true,"text":"associated with improved endothelial function (21-30). Mobilizing EPC reserves may improve walking","text_display":" associated with improved endothelial function (21-30). Mobilizing EPC reserves may improve walking","confidence":0.9599802494049072,"confidence_rate":0.9996035488185323},{"cnt":[[120,735],[1979,735],[1979,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1859,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e4aff88ec50249a5b053f163acf9fb5a","type":"text","conversion_output":true,"text":"performance in patients with PAD by increasing calf muscle perfusion through angiogenesis and by improving","text_display":" performance in patients with PAD by increasing calf muscle perfusion through angiogenesis and by improving","confidence":0.9931640625,"confidence_rate":0.9999382054269228},{"cnt":[[120,778],[1884,778],[1884,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1765,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb87284f01eb4c509fd39867ecd085a9","type":"text","conversion_output":true,"text":"endothelial function and cardiovascular health. However, whether interventions that increase circulating","text_display":" endothelial function and cardiovascular health. However, whether interventions that increase circulating","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1689,821],[1689,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1569,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd9514925db842b885509d5b95df52ca","type":"text","conversion_output":true,"text":"progenitor cell levels improve functional performance in patients with PAD is not established.","text_display":" progenitor cell levels improve functional performance in patients with PAD is not established.","confidence":1,"confidence_rate":1},{"cnt":[[120,907],[1940,907],[1940,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1821,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1277ee8918a247f5af54201928de1ad5","type":"text","conversion_output":true,"text":"A4. Therapeutic potential of CD34+ progenitor cells. The CD34+ cell marker clearly identifies functional","text_display":"\n\nA4. Therapeutic potential of CD34+ progenitor cells. The CD34+ cell marker clearly identifies functional","confidence":0.9980480668600649,"confidence_rate":0.9999820750171311},{"cnt":[[120,954],[1936,954],[1936,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1816,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"178e151e789143bba0131e822dea7c58","type":"text","conversion_output":true,"text":"progenitor cell populations that are released from bone marrow in response to tissue ischemia, differentiate","text_display":" progenitor cell populations that are released from bone marrow in response to tissue ischemia, differentiate","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1901,997],[1901,1044],[120,1044]],"region":{"top_left_x":120,"top_left_y":996,"width":1782,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d4a3ba3486c402bb5987bf66f808f38","type":"text","conversion_output":true,"text":"into endothelial cells, and promote angiogenesis in vitro and in vivo ( \\(22,31,32\\) ). In addition to the work by","text_display":" into endothelial cells, and promote angiogenesis in vitro and in vivo ( \\(22,31,32\\) ). In addition to the work by","confidence":0.8142565595917404,"confidence_rate":0.9982601612191198},{"cnt":[[120,1040],[1897,1040],[1897,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1039,"width":1778,"height":49},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e4aeb0a981a4bbdbbdf02313cb5f48b","type":"text","conversion_output":true,"text":"Asahara and colleagues described in section A3 (22), Ishida and colleagues harvested CD34+ cells from","text_display":" Asahara and colleagues described in section A3 (22), Ishida and colleagues harvested CD34+ cells from","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,1087],[1815,1087],[1815,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1696,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dab5ec68c2e241a78c194d4a16e9b631","type":"text","conversion_output":true,"text":"peripheral blood and injected them into calf muscle of six patients with peripheral ischemia (five with","text_display":" peripheral blood and injected them into calf muscle of six patients with peripheral ischemia (five with","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1989,1130],[1989,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1870,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb227f06dd1a465fab0a33d2ea6241a9","type":"text","conversion_output":true,"text":"thromboangiitis obliterans and one with critical limb ischemia). At six-week follow-up, participants experienced","text_display":" thromboangiitis obliterans and one with critical limb ischemia). At six-week follow-up, participants experienced","confidence":0.9990234375,"confidence_rate":0.9999916492686468},{"cnt":[[120,1173],[1989,1173],[1989,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1870,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b409046338594c23a430f33e9535c731","type":"text","conversion_output":true,"text":"a \\(200 \\%\\) increase in treadmill walking distance (32). However, the sample size was small and did not include a","text_display":" a \\(200 \\%\\) increase in treadmill walking distance (32). However, the sample size was small and did not include a","confidence":0.9960968487430364,"confidence_rate":0.9999662868749294},{"cnt":[[120,1216],[1934,1216],[1934,1261],[120,1261]],"region":{"top_left_x":120,"top_left_y":1216,"width":1814,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48bbefbc03dc4f2baac7d7d6512b6c97","type":"text","conversion_output":true,"text":"control group. It is currently not established whether interventions that increase circulating levels of CD34+","text_display":" control group. It is currently not established whether interventions that increase circulating levels of CD34+","confidence":1,"confidence_rate":1},{"cnt":[[120,1261],[1184,1261],[1184,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1261,"width":1064,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"27a8bf1350974cb9bc4b3446282a4802","type":"text","conversion_output":true,"text":"cells can improve functional performance in patients with PAD.","text_display":" cells can improve functional performance in patients with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[116,1347],[1992,1347],[1992,1394],[116,1394]],"region":{"top_left_x":116,"top_left_y":1347,"width":1876,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0430bd0d7148422ba42865e702828f08","type":"text","conversion_output":true,"text":"A5. Preliminary evidence suggests that GM-CSF may improve walking performance in people with PAD","text_display":"\n\nA5. Preliminary evidence suggests that GM-CSF may improve walking performance in people with PAD","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1966,1392],[1966,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1846,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03a8a46944744b35932de6f5d8bced3f","type":"text","conversion_output":true,"text":"by increasing CD34+ cells. Subcutaneous GM-CSF injections increase levels of circulating CD34+ cells by","text_display":" by increasing CD34+ cells. Subcutaneous GM-CSF injections increase levels of circulating CD34+ cells by","confidence":1,"confidence_rate":1},{"cnt":[[120,1437],[1951,1437],[1951,1482],[120,1482]],"region":{"top_left_x":120,"top_left_y":1437,"width":1831,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6cf31de676d4584acc11c9970a989d6","type":"text","conversion_output":true,"text":"disrupting progenitor cell anchors in the bone marrow (33). In hind-limb ischemia animal models, increasing","text_display":" disrupting progenitor cell anchors in the bone marrow (33). In hind-limb ischemia animal models, increasing","confidence":0.9985356330871582,"confidence_rate":0.9999869157985816},{"cnt":[[120,1480],[1934,1480],[1934,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1814,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa26ea98096b455589121d47935ab065","type":"text","conversion_output":true,"text":"circulating levels of progenitor cells is associated with calf muscle capillary formation, improved calf muscle","text_display":" circulating levels of progenitor cells is associated with calf muscle capillary formation, improved calf muscle","confidence":1,"confidence_rate":1},{"cnt":[[120,1525],[1919,1525],[1919,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":1799,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cca8917ea5f941228fb3045393744e0c","type":"text","conversion_output":true,"text":"perfusion, and increased exercise capacity ( \\(22,31,32\\) ). However, three prior small clinical trials testing the","text_display":" perfusion, and increased exercise capacity ( \\(22,31,32\\) ). However, three prior small clinical trials testing the","confidence":0.953659046208486,"confidence_rate":0.9996013478415039},{"cnt":[[120,1568],[1983,1568],[1983,1613],[120,1613]],"region":{"top_left_x":120,"top_left_y":1568,"width":1864,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5b9193c61f94b868623a226ca7b5b94","type":"text","conversion_output":true,"text":"ability of GM-CSF (or G-CSF) to improve walking performance in patients with PAD have shown mixed results","text_display":" ability of GM-CSF (or G-CSF) to improve walking performance in patients with PAD have shown mixed results","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[1867,1611],[1867,1659],[120,1659]],"region":{"top_left_x":120,"top_left_y":1611,"width":1747,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9ef4a895475480c8069e46c8a9db7be","type":"text","conversion_output":true,"text":"\\((1,3,4)\\). Of these three randomized controlled clinical trials (summarized in Table 1), one demonstrated","text_display":" \\((1,3,4)\\). Of these three randomized controlled clinical trials (summarized in Table 1), one demonstrated","confidence":0.99853515625,"confidence_rate":0.999986426780242},{"cnt":[[120,1656],[1966,1656],[1966,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1656,"width":1846,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29968f58bd6340b49e334ff9f7d91caa","type":"text","conversion_output":true,"text":"improved maximal walking distance (1) and one demonstrated no change in treadmill walking performance in","text_display":" improved maximal walking distance (1) and one demonstrated no change in treadmill walking performance in","confidence":0.95556640625,"confidence_rate":0.9995831051013214},{"cnt":[[120,1699],[1953,1699],[1953,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1699,"width":1833,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84270ae4d7a64661bcfcfc36cb3ca746","type":"text","conversion_output":true,"text":"response to GM-CSF (3). While the third study demonstrated improved pain-free treadmill walking distance,","text_display":" response to GM-CSF (3). While the third study demonstrated improved pain-free treadmill walking distance,","confidence":0.9990234375,"confidence_rate":0.9999911178608298},{"cnt":[[120,1745],[1979,1745],[1979,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1859,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a1cf24fccf4410085e3f7b3b7e48bd4","type":"text","conversion_output":true,"text":"the validity of this finding is questionable, since only four participants completed follow-up treadmill testing (4).","text_display":" the validity of this finding is questionable, since only four participants completed follow-up treadmill testing (4).","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1944,1788],[1944,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1825,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"299e664a84264578a0cbf6bebd6b3c06","type":"text","conversion_output":true,"text":"Additional limitations of these studies follow. First, sample sizes were small. Second, generalizability of the","text_display":" Additional limitations of these studies follow. First, sample sizes were small. Second, generalizability of the","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1895,1830],[1895,1876],[120,1876]],"region":{"top_left_x":120,"top_left_y":1830,"width":1775,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6b08ffbb4074001b681c2f6799b8c0a","type":"text","conversion_output":true,"text":"findings to the typical patient with PAD is limited. Participants in the study by Arai and colleagues all had","text_display":" findings to the typical patient with PAD is limited. Participants in the study by Arai and colleagues all had","confidence":1,"confidence_rate":1},{"cnt":[[120,1876],[1996,1876],[1996,1921],[120,1921]],"region":{"top_left_x":120,"top_left_y":1875,"width":1876,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5282e75e838343668ac1bad8a1ae3cda","type":"text","conversion_output":true,"text":"critical limb ischemia (4), those in the study by Van Royan and colleagues all had maximal walking distances <","text_display":" critical limb ischemia (4), those in the study by Van Royan and colleagues all had maximal walking distances <","confidence":0.9990236759185791,"confidence_rate":0.999991506114367},{"cnt":[[120,1919],[1957,1919],[1957,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1838,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e966784d080044cab26f07b87e473390","type":"text","conversion_output":true,"text":"200 meters ( 3 ), and those in the study by Subramaniyam and colleagues all had intermittent claudication (1).","text_display":" 200 meters ( 3 ), and those in the study by Subramaniyam and colleagues all had intermittent claudication (1).","confidence":0.8662685491144657,"confidence_rate":0.9987737412261591},{"cnt":[[120,1964],[1987,1964],[1987,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1868,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"618cb0054e46490784a587c65de89481","type":"text","conversion_output":true,"text":"Yet most PAD participants will never have critical limb ischemia, many can walk > 200 meters on the treadmill,","text_display":" Yet most PAD participants will never have critical limb ischemia, many can walk > 200 meters on the treadmill,","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[120,2007],[1936,2007],[1936,2052],[120,2052]],"region":{"top_left_x":120,"top_left_y":2006,"width":1816,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d1486a26a1e4321906388cefbbb2e30","type":"text","conversion_output":true,"text":"and most do not have symptoms of intermittent claudication \\((6,8,34,35)\\). Third, no study assessed whether","text_display":" and most do not have symptoms of intermittent claudication \\((6,8,34,35)\\). Third, no study assessed whether","confidence":0.95458984375,"confidence_rate":0.9995888145268306},{"cnt":[[120,2052],[1987,2052],[1987,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2051,"width":1868,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5410ef56b6df4747abb228c5755413bc","type":"text","conversion_output":true,"text":"episodes of lower extremity ischemia, induced during supervised treadmill exercise, increases responsiveness","text_display":" episodes of lower extremity ischemia, induced during supervised treadmill exercise, increases responsiveness","confidence":1,"confidence_rate":1},{"cnt":[[120,2093],[2000,2093],[2000,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2092,"width":1881,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a0d84cc39374432b80bcda7c603a0c6","type":"text","conversion_output":true,"text":"to GM-CSF. Fourth, temporal trends in walking outcomes in response to the intervention were not evaluated in","text_display":" to GM-CSF. Fourth, temporal trends in walking outcomes in response to the intervention were not evaluated in","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1893,2140],[1893,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1773,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19b1aa1ce2bd4780ae673c46f3f729f2","type":"text","conversion_output":true,"text":"any study. The length of time required to achieve maximal benefit from GM-CSF and the duration of any","text_display":" any study. The length of time required to achieve maximal benefit from GM-CSF and the duration of any","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,2183],[1854,2183],[1854,2228],[120,2228]],"region":{"top_left_x":120,"top_left_y":2182,"width":1735,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b081f99727841cd8733d688c7e1878d","type":"text","conversion_output":true,"text":"therapeutic benefit is unknown. In summary, whether GM-CSF (or G-CSF) improves treadmill walking","text_display":" therapeutic benefit is unknown. In summary, whether GM-CSF (or G-CSF) improves treadmill walking","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1910,2226],[1910,2271],[120,2271]],"region":{"top_left_x":120,"top_left_y":2225,"width":1790,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a0e33cf78124a149d2e313b086944e3","type":"text","conversion_output":true,"text":"performance, with or without supervised treadmill exercise, remains unknown. A definitive trial is needed.","text_display":" performance, with or without supervised treadmill exercise, remains unknown. A definitive trial is needed.","confidence":1,"confidence_rate":1},{"cnt":[[146,2443],[1979,2443],[1979,2539],[146,2539]],"region":{"top_left_x":146,"top_left_y":2442,"width":1833,"height":98},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"857a6572901b4bc7a449ff8ac085fd23","type":"section_header","conversion_output":false,"children_ids":["40eb36200be744fdbd7abe9e47465289","43ab0f1c2f0f422180d3d24b0ad32c25"],"text":"","text_display":""},{"cnt":[[150,2445],[1974,2445],[1974,2494],[150,2494]],"region":{"top_left_x":150,"top_left_y":2444,"width":1825,"height":51},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40eb36200be744fdbd7abe9e47465289","type":"text","conversion_output":true,"parent_id":"857a6572901b4bc7a449ff8ac085fd23","text":"Table 1. Summary of Prior Small Clinical Trials Studying the Ability of G-CSF or GM-CSF Therapy to","text_display":"\n\n\\section*{Table 1. 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Small sample size. 2. Limited to PAD participants with IC and short maximal walking distance. 3. No supervised exercise therapy. \\\\\n\\hline Arai M et al (2006) (4) & 39 participants with PAD and critical leg ischemia. & G-CSF for 10 days ( \\(N =14\\) ) vs. bone marrow transplant and calf injection of mononuclear cells ( \\(N =13\\) ) vs. usual care ( \\(N =12\\) ). & Treadmill painfree walking time, ABI, and transcutaneous oxygen saturation at 4week follow-up. & G-CSF and bone marrow transplant were each associated with greater improvement in each outcome compared to usual care. & \\begin{tabular}{l}\n1. Small sample size. 2. Limited to participants with critical limb ischemia. \\\\\n3. Only 4 participants completed treadmill test at follow-up.\n\\end{tabular} \\\\\n\\hline Subramaniya m et al (2009) (1) & 45 with PAD and intermittent claudication. & GM-CSF ( \\(N =29\\) ) vs. placebo injections ( \\(N =16\\) ) three times weekly for two weeks. All participants were instructed to exercise. & CD34+ cells, brachial artery FMD, and walking performance at 12-week followup. & GM-CSF was associated with significant increases in CD34+ cells, brachial artery FMD, and treadmill performance, compared to placebo. & 1. Small sample size. 2. Participants exercised on their own. Exercise adherence was not measured and is known to be poor in PAD (36). \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{tabular}{|l|l|l|l|l|l|}\n\\hline Study & Participants & Intervention(s) & Outcome Measure & Results & Study Limitations \\\\\n\\hline Van Royen N et al (2005) (3) & 40 with PAD and intermittent claudication (IC) who walked < 200 meters on the treadmill. & GM-CSF vs. placebo injections over 14 days. & Maximal treadmill walking time at 12-week followup. & No difference between the intervention vs. control group in increasing treadmill walking performance. & 1. Small sample size. 2. Limited to PAD participants with IC and short maximal walking distance. 3. No supervised exercise therapy. \\\\\n\\hline Arai M et al (2006) (4) & 39 participants with PAD and critical leg ischemia. & G-CSF for 10 days ( \\(N =14\\) ) vs. bone marrow transplant and calf injection of mononuclear cells ( \\(N =13\\) ) vs. usual care ( \\(N =12\\) ). & Treadmill painfree walking time, ABI, and transcutaneous oxygen saturation at 4week follow-up. & G-CSF and bone marrow transplant were each associated with greater improvement in each outcome compared to usual care. & \\begin{tabular}{l}\n1. Small sample size. 2. Limited to participants with critical limb ischemia. \\\\\n3. Only 4 participants completed treadmill test at follow-up.\n\\end{tabular} \\\\\n\\hline Subramaniya m et al (2009) (1) & 45 with PAD and intermittent claudication. & GM-CSF ( \\(N =29\\) ) vs. placebo injections ( \\(N =16\\) ) three times weekly for two weeks. 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PAD- Peripheral arterial disease. ABI- Ankle brachial index. FMD-Flow mediated dilation.","text_display":"\n\nIC- Intermittent claudication. PAD- Peripheral arterial disease. ABI- Ankle brachial index. FMD-Flow mediated dilation.","confidence":1,"confidence_rate":1},{"cnt":[[129,1265],[1992,1265],[1992,1313],[129,1313]],"region":{"top_left_x":128,"top_left_y":1265,"width":1864,"height":48},"line":140,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a7f998da8fc44a35b2d850c97ee225f4","type":"text","conversion_output":true,"text":"A6. Supervised treadmill exercise may increase responsiveness to GM-CSF therapy in PAD. Treadmill","text_display":"\nA6. Supervised treadmill exercise may increase responsiveness to GM-CSF therapy in PAD. Treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,1311],[1914,1311],[1914,1356],[120,1356]],"region":{"top_left_x":120,"top_left_y":1310,"width":1795,"height":46},"line":141,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f3b5cb5519043ceba5725943ce57054","type":"text","conversion_output":true,"text":"exercise induces lower extremity tissue ischemia in patients with PAD. Experimental and animal research","text_display":" exercise induces lower extremity tissue ischemia in patients with PAD. Experimental and animal research","confidence":1,"confidence_rate":1},{"cnt":[[120,1354],[1897,1354],[1897,1399],[120,1399]],"region":{"top_left_x":120,"top_left_y":1353,"width":1778,"height":46},"line":142,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d389a151bb3a49c3836ada453c73fa23","type":"text","conversion_output":true,"text":"demonstrate that tissue ischemia and hypoxia promote release of progenitor cells from bone marrow and","text_display":" demonstrate that tissue ischemia and hypoxia promote release of progenitor cells from bone marrow and","confidence":1,"confidence_rate":1},{"cnt":[[120,1399],[1987,1399],[1987,1444],[120,1444]],"region":{"top_left_x":120,"top_left_y":1398,"width":1868,"height":46},"line":143,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1c109719ab8549828f2dc8d5bb1a40c2","type":"text","conversion_output":true,"text":"encourage homing of progenitor cells to ischemic sites (37-41). Homing of progenitor cells to ischemic sites is","text_display":" encourage homing of progenitor cells to ischemic sites (37-41). 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Myocardial ischemia increases responsiveness to G-CSF in","text_display":" tissue receptors on progenitor cells (37-43). Myocardial ischemia increases responsiveness to G-CSF in","confidence":0.989771842956543,"confidence_rate":0.9999039221477919},{"cnt":[[120,1530],[1934,1530],[1934,1575],[120,1575]],"region":{"top_left_x":120,"top_left_y":1529,"width":1814,"height":46},"line":146,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d41757cb414a490dbaee5090aec80c23","type":"text","conversion_output":true,"text":"patients with coronary artery disease (40). Together, these data suggest that tissue ischemia, such as that","text_display":" patients with coronary artery disease (40). Together, these data suggest that tissue ischemia, such as that","confidence":1,"confidence_rate":1},{"cnt":[[120,1573],[1953,1573],[1953,1618],[120,1618]],"region":{"top_left_x":120,"top_left_y":1572,"width":1833,"height":46},"line":147,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cbcd0e4e489f4e699f422b2c1c99fa85","type":"text","conversion_output":true,"text":"induced during supervised treadmill exercise, may increase responsiveness to GM-CSF. However, whether","text_display":" induced during supervised treadmill exercise, may increase responsiveness to GM-CSF. However, whether","confidence":1,"confidence_rate":1},{"cnt":[[120,1618],[1974,1618],[1974,1663],[120,1663]],"region":{"top_left_x":120,"top_left_y":1617,"width":1855,"height":46},"line":148,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"61707f142e6c4e1bbf7f33aada5b16e7","type":"text","conversion_output":true,"text":"GM-CSF combined with supervised treadmill exercise improves functional performance more than either GM-","text_display":" GM-CSF combined with supervised treadmill exercise improves functional performance more than either GM","confidence":1,"confidence_rate":1},{"cnt":[[120,1661],[1171,1661],[1171,1708],[120,1708]],"region":{"top_left_x":120,"top_left_y":1660,"width":1051,"height":49},"line":149,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b54e21ccd35a4bcf973a9b6d4002ca5c","type":"text","conversion_output":true,"text":"CSF alone or supervised treadmill exercise alone is unknown.","text_display":"CSF alone or supervised treadmill exercise alone is unknown.","confidence":1,"confidence_rate":1},{"cnt":[[120,1749],[1824,1749],[1824,1794],[120,1794]],"region":{"top_left_x":120,"top_left_y":1748,"width":1705,"height":46},"line":150,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"385dc0fbb06f43b5a8400c1361d20d08","type":"text","conversion_output":true,"text":"A7. Supervised treadmill exercise may improve walking performance in patients with PAD by","text_display":"\n\nA7. Supervised treadmill exercise may improve walking performance in patients with PAD by","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[120,1839],[120,1792],[1910,1794],[1910,1841]],"region":{"top_left_x":120,"top_left_y":1791,"width":1791,"height":51},"line":151,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad452389673c422fa147ce0579033c16","type":"text","conversion_output":true,"text":"increasing circulating progenitor cell levels. Our prior randomized controlled clinical trial (the Study to","text_display":" increasing circulating progenitor cell levels. Our prior randomized controlled clinical trial (the Study to","confidence":1,"confidence_rate":1},{"cnt":[[120,1839],[1910,1839],[1910,1884],[120,1884]],"region":{"top_left_x":120,"top_left_y":1839,"width":1790,"height":46},"line":152,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0815e4b4df204110947a9102d1ec5dbf","type":"text","conversion_output":true,"text":"Improve Leg Circulation (SILC)) compared the ability of a supervised treadmill exercise intervention and a","text_display":" Improve Leg Circulation (SILC)) compared the ability of a supervised treadmill exercise intervention and a","confidence":1,"confidence_rate":1},{"cnt":[[120,1882],[1931,1882],[1931,1927],[120,1927]],"region":{"top_left_x":120,"top_left_y":1882,"width":1812,"height":46},"line":153,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d4fa99c43c9e42e894795ac2c3f8971e","type":"text","conversion_output":true,"text":"supervised lower extremity resistance training intervention, respectively, to improve functional performance","text_display":" supervised lower extremity resistance training intervention, respectively, to improve functional performance","confidence":1,"confidence_rate":1},{"cnt":[[120,1925],[1815,1925],[1815,1970],[120,1970]],"region":{"top_left_x":120,"top_left_y":1925,"width":1696,"height":46},"line":154,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f4580107ba14ec6af6ec16c604d62b1","type":"text","conversion_output":true,"text":"and brachial artery flow-mediated dilation in 156 PAD participants, both with and without intermittent","text_display":" and brachial artery flow-mediated dilation in 156 PAD participants, both with and without intermittent","confidence":1,"confidence_rate":1},{"cnt":[[120,1970],[1910,1968],[1910,2015],[120,2017]],"region":{"top_left_x":120,"top_left_y":1967,"width":1791,"height":51},"line":155,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0061d25fd40a497bb54679128941d569","type":"text","conversion_output":true,"text":"claudication symptoms (R01-HL073351) (44). 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}^{1} p <0.001 vs\\). control; \\({ }^{2} p =0.009 vs\\). control; \\({ }^{3} p =0.02 vs\\). control. FMD- flow mediated dilation.","text_display":"\n\\({ }^{1} p <0.001 vs\\). control; \\({ }^{2} p =0.009 vs\\). control; \\({ }^{3} p =0.02 vs\\). control. FMD- flow mediated dilation.","confidence":0.6834388172580699,"confidence_rate":0.9973231796482941},{"cnt":[[120,2466],[1841,2466],[1841,2512],[120,2512]],"region":{"top_left_x":120,"top_left_y":2466,"width":1722,"height":46},"line":194,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"25543dad8b5842b2a5bd5df70fdd8e1f","type":"text","conversion_output":true,"text":"As shown in Table 2, our SILC trial demonstrated that supervised treadmill exercise improves walking","text_display":"\nAs shown in Table 2, our SILC trial demonstrated that supervised treadmill exercise improves walking","confidence":1,"confidence_rate":1},{"cnt":[[120,2509],[1992,2509],[1992,2557],[120,2557]],"region":{"top_left_x":120,"top_left_y":2509,"width":1872,"height":48},"line":195,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0bd07b2735fa42d19920cc43fed25b82","type":"text","conversion_output":true,"text":"performance and brachial artery flow-mediated dilation (FMD) in PAD participants with and without intermittent","text_display":" performance and brachial artery flow-mediated dilation (FMD) in PAD participants with and without intermittent","confidence":1,"confidence_rate":1},{"cnt":[[1048,2582],[1079,2582],[1079,2628],[1048,2628]],"region":{"top_left_x":1048,"top_left_y":2582,"width":31,"height":46},"line":196,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"100957e7e6cb4a3d9355771a99c96461","type":"page_info","conversion_output":false,"text":"4","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-05","page":5,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"062c19511f534b76a127f21afec5707d","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,161],[1740,161]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9e29b58e4bd498fba851108a7613dc8","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1899,206],[1899,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1780,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11ebfb7ab25d467bbdb5c2d1f95b7216","type":"text","conversion_output":true,"text":"claudication (44). SILC was the first randomized controlled trial to demonstrate that supervised treadmill","text_display":"\nclaudication (44). SILC was the first randomized controlled trial to demonstrate that supervised treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[2002,249],[2002,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1883,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d637e39e1a04c6189d488a7ff72c356","type":"text","conversion_output":true,"text":"exercise improves brachial artery FMD, a measure of endothelial function, in PAD (44). However, mechanisms","text_display":" exercise improves brachial artery FMD, a measure of endothelial function, in PAD (44). However, mechanisms","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,296],[1869,296],[1869,339],[120,339]],"region":{"top_left_x":120,"top_left_y":296,"width":1750,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51acdfaf45b449dfbc654a976a402da2","type":"text","conversion_output":true,"text":"of the favorable associations shown in Table 2 are unknown. We hypothesize that supervised treadmill","text_display":" of the favorable associations shown in Table 2 are unknown. We hypothesize that supervised treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1472,339],[1472,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1352,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b936cbc0f3594d9faad36e622c10158e","type":"text","conversion_output":true,"text":"exercise may improve outcomes by increasing circulating levels of CD34+ cells.","text_display":" exercise may improve outcomes by increasing circulating levels of CD34+ cells.","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1987,425],[1987,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1868,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec3f948599e24d729eb8a240d284c48e","type":"text","conversion_output":true,"text":"A8. Preliminary evidence suggests that walking exercise may increase circulating CD34+ cell levels in","text_display":"\n\nA8. Preliminary evidence suggests that walking exercise may increase circulating CD34+ cell levels in","confidence":0.9990234375,"confidence_rate":0.9999907826873115},{"cnt":[[120,473],[1970,473],[1970,518],[120,518]],"region":{"top_left_x":120,"top_left_y":472,"width":1851,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fbdbba82a5c48aaa0f8158e00234c03","type":"text","conversion_output":true,"text":"patients with PAD. Patients with PAD experience calf muscle ischemia during supervised treadmill exercise.","text_display":" patients with PAD. Patients with PAD experience calf muscle ischemia during supervised treadmill exercise.","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[2002,516],[2002,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1883,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c77246d25f5b4f7d8b3692d038aa9240","type":"text","conversion_output":true,"text":"Experimental and animal studies demonstrate that tissue ischemia promotes endogenous release of progenitor","text_display":" Experimental and animal studies demonstrate that tissue ischemia promotes endogenous release of progenitor","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1815,559],[1815,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1696,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f3866abe93c43988de362a3b3da06da","type":"text","conversion_output":true,"text":"cells and increases homing of the progenitor cells to sites of tissue ischemia (37-43). Several small,","text_display":" cells and increases homing of the progenitor cells to sites of tissue ischemia (37-43). Several small,","confidence":0.9975600242614746,"confidence_rate":0.999977168883715},{"cnt":[[120,602],[1962,602],[1962,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1842,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7dbcd5e085c43b3856bd4cbea83727f","type":"text","conversion_output":true,"text":"uncontrolled, or non-randomized trials have demonstrated that exercise increases circulating progenitor cells","text_display":" uncontrolled, or non-randomized trials have demonstrated that exercise increases circulating progenitor cells","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1955,645],[1955,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1836,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"344a58c9f72344e49436b9a236a04a7d","type":"text","conversion_output":true,"text":"in patients without PAD (21,44-48). However, people with PAD have fewer circulating progenitor cells and","text_display":" in patients without PAD (21,44-48). However, people with PAD have fewer circulating progenitor cells and","confidence":0.5403003692626953,"confidence_rate":0.9943679377122548},{"cnt":[[120,690],[1931,690],[1931,735],[120,735]],"region":{"top_left_x":120,"top_left_y":689,"width":1812,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4bd6e13bc9dd4ae98cea932d7d51d32b","type":"text","conversion_output":true,"text":"exercise at a lower intensity than people without PAD \\((49,50)\\). Only one previous publication describes the","text_display":" exercise at a lower intensity than people without PAD \\((49,50)\\). Only one previous publication describes the","confidence":0.8490681648254395,"confidence_rate":0.9985782654711017},{"cnt":[[120,735],[1979,735],[1979,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1859,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fab637297768490384343eff85cc5682","type":"text","conversion_output":true,"text":"association of exercise training with changes in circulating progenitor cells among patients with PAD (2). This","text_display":" association of exercise training with changes in circulating progenitor cells among patients with PAD (2). This","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1983,778],[1983,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1864,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98fb5b530e8d48cb8935036b3f3baeea","type":"text","conversion_output":true,"text":"publication reports results from two small randomized controlled trials. Study A included 18 patients with PAD","text_display":" publication reports results from two small randomized controlled trials. Study A included 18 patients with PAD","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1983,821],[1983,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1864,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e435ca0527d046eb9484f3d2dd4868c1","type":"text","conversion_output":true,"text":"and intermittent claudication without history of lower extremity revascularization. Study B included 18 patients","text_display":" and intermittent claudication without history of lower extremity revascularization. Study B included 18 patients","confidence":1,"confidence_rate":1},{"cnt":[[120,866],[1992,866],[1992,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1872,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f5ebddf8d514b4baaa1408c75afc5b2","type":"text","conversion_output":true,"text":"with PAD and intermittent claudication with a history of lower extremity revascularization. Participants in Study","text_display":" with PAD and intermittent claudication with a history of lower extremity revascularization. Participants in Study","confidence":1,"confidence_rate":1},{"cnt":[[120,911],[1970,911],[1970,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1851,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d5505613e9e4d3181933fc3533bf1c9","type":"text","conversion_output":true,"text":"A and Study B were randomized to either unsupervised treadmill exercise or no exercise for four weeks. The","text_display":" A and Study B were randomized to either unsupervised treadmill exercise or no exercise for four weeks. The","confidence":0.84033203125,"confidence_rate":0.9984340365019531},{"cnt":[[120,954],[1987,954],[1987,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1868,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4aa8a0efeaa142638010c9ea74af9c9d","type":"text","conversion_output":true,"text":"unsupervised treadmill walking was performed 30 times per week: ten times more frequently than the exercise","text_display":" unsupervised treadmill walking was performed 30 times per week: ten times more frequently than the exercise","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[120,999],[1992,999],[1992,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":999,"width":1872,"height":43},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6451496da9384ae9ab46c2822d08d966","type":"text","conversion_output":true,"text":"currently recommended in clinical practice guidelines for PAD \\((2,35)\\). At four-week follow-up, PAD participants","text_display":" currently recommended in clinical practice guidelines for PAD \\((2,35)\\). At four-week follow-up, PAD participants","confidence":0.7548828125,"confidence_rate":0.9976398252579317},{"cnt":[[120,1042],[1798,1042],[1798,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1041,"width":1679,"height":47},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"947701c05e2a4786be931db8c90c5ce7","type":"text","conversion_output":true,"text":"randomized to exercise in Study A had significant increases in CD34+ cells, while PAD participants","text_display":" randomized to exercise in Study A had significant increases in CD34+ cells, while PAD participants","confidence":1,"confidence_rate":1},{"cnt":[[120,1087],[1876,1087],[1876,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1756,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ae10cecee064d82bc49d3706e036f7f","type":"text","conversion_output":true,"text":"randomized to exercise in Study B had no increases in CD34+ cells. Neither control group experienced","text_display":" randomized to exercise in Study B had no increases in CD34+ cells. Neither control group experienced","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1878,1130],[1878,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1758,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f371e3b82e2e4a989b84edbba9dcee54","type":"text","conversion_output":true,"text":"increases in CD34+ cells. This preliminary work demonstrates that unsupervised treadmill exercise may","text_display":" increases in CD34+ cells. This preliminary work demonstrates that unsupervised treadmill exercise may","confidence":0.9951171875,"confidence_rate":0.999953823968252},{"cnt":[[120,1173],[1914,1173],[1914,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1795,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ccfb6571848d4c738b0836b8b62347ce","type":"text","conversion_output":true,"text":"increase CD34+ cells in patients with PAD. However, the walking exercise intervention was performed 10","text_display":" increase CD34+ cells in patients with PAD. However, the walking exercise intervention was performed 10","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[1992,1216],[1992,1261],[120,1261]],"region":{"top_left_x":120,"top_left_y":1216,"width":1872,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3146e2060edf467b8540fe31a90e0c80","type":"text","conversion_output":true,"text":"times more frequently than the exercise frequency recommended by PAD clinical practice guidelines (35). It is","text_display":" times more frequently than the exercise frequency recommended by PAD clinical practice guidelines (35). 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Theoretical model for our proposed PROPEL Study.","text_display":"\n\n\\section*{A9. Theoretical model for our proposed PROPEL Study.}","confidence":0.9975600242614746,"confidence_rate":0.9999571420178975},{"cnt":[[150,1478],[1974,1478],[1974,1566],[150,1566]],"region":{"top_left_x":150,"top_left_y":1478,"width":1825,"height":89},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"84e6e591cead47bbbd3b96404e26b63a","type":"figure_label","conversion_output":false,"children_ids":["d534f879fceb45a98510692c469e8bc4","952a8c3124d34e87945f9193eab05cf7"],"text":"","text_display":""},{"cnt":[[155,1482],[1970,1482],[1970,1523],[155,1523]],"region":{"top_left_x":154,"top_left_y":1482,"width":1817,"height":42},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d534f879fceb45a98510692c469e8bc4","type":"text","conversion_output":false,"parent_id":"84e6e591cead47bbbd3b96404e26b63a","text":"Figure 1. Theoretical Model for Associations of Study Interventions with Improved Functional Performance in","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[692,1521],[1429,1521],[1429,1562],[692,1562]],"region":{"top_left_x":691,"top_left_y":1521,"width":738,"height":41},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"952a8c3124d34e87945f9193eab05cf7","type":"text","conversion_output":false,"parent_id":"84e6e591cead47bbbd3b96404e26b63a","text":"Participants with Peripheral Arterial Disease","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[142,1566],[1927,1566],[1927,2078],[142,2078]],"region":{"top_left_x":141,"top_left_y":1566,"width":1787,"height":512},"line":33,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"a59a0f6a29724a0190fe761bf59a0826","type":"diagram","conversion_output":true,"selected_labels":["84e6e591cead47bbbd3b96404e26b63a"],"text":"","text_display":"\n\n\\begin{figure}\n\\captionsetup{labelformat=empty}\n\\caption{Figure 1. Theoretical Model for Associations of Study Interventions with Improved Functional Performance in Participants with Peripheral Arterial Disease}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/e63f6bd9-8a76-4101-acf6-184b5e738ce4-05.jpg?height=512&width=1787&top_left_y=1566&top_left_x=141}\n\\end{figure}"},{"cnt":[[120,2170],[1940,2170],[1940,2211],[120,2211]],"region":{"top_left_x":120,"top_left_y":2169,"width":1821,"height":42},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5614f23c98c342a286ad5126441b0ba2","type":"text","conversion_output":true,"text":"As described in Sections A3 and A4 above, experimental and animal data demonstrate that progenitor cells","text_display":"\n\nAs described in Sections A3 and A4 above, experimental and animal data demonstrate that progenitor cells","confidence":1,"confidence_rate":1},{"cnt":[[120,2213],[1921,2213],[1921,2258],[120,2258]],"region":{"top_left_x":120,"top_left_y":2212,"width":1801,"height":47},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c3de3b1041a44c5aa695ba4a8b1dc47","type":"text","conversion_output":true,"text":"released into the circulation can differentiate into endothelial cells, form new blood vessels (angiogenesis),","text_display":" released into the circulation can differentiate into endothelial cells, form new blood vessels (angiogenesis),","confidence":1,"confidence_rate":1},{"cnt":[[120,2256],[1992,2256],[1992,2301],[120,2301]],"region":{"top_left_x":120,"top_left_y":2255,"width":1872,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a12d4c6bc2664081862b54cfe7973522","type":"text","conversion_output":true,"text":"repair injured endothelium, and improve endothelial function (22-24). Preliminary data also suggest that tissue","text_display":" repair injured endothelium, and improve endothelial function (22-24). Preliminary data also suggest that tissue","confidence":1,"confidence_rate":1},{"cnt":[[120,2299],[1962,2299],[1962,2344],[120,2344]],"region":{"top_left_x":120,"top_left_y":2298,"width":1842,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c746fec87174e5e978cbf1bf1cbe54e","type":"text","conversion_output":true,"text":"ischemia, such as that induced by walking exercise in patients with PAD, may increase circulating progenitor","text_display":" ischemia, such as that induced by walking exercise in patients with PAD, may increase circulating progenitor","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[120,2342],[1944,2342],[1944,2387],[120,2387]],"region":{"top_left_x":120,"top_left_y":2341,"width":1825,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60a5e02b57474e0897a5d0bb0ec92ae5","type":"text","conversion_output":true,"text":"cells and promote their homing to sites of tissue ischemia (37-43). We hypothesize that GM-CSF combined","text_display":" cells and promote their homing to sites of tissue ischemia (37-43). We hypothesize that GM-CSF combined","confidence":0.9844338893890381,"confidence_rate":0.9998547463409243},{"cnt":[[120,2385],[1867,2385],[1867,2430],[120,2430]],"region":{"top_left_x":120,"top_left_y":2384,"width":1747,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"431859ec03a94d9cb966df65dd41b6b8","type":"text","conversion_output":true,"text":"with supervised treadmill exercise maximizes circulating levels of CD34+ cells in patients with PAD and","text_display":" with supervised treadmill exercise maximizes circulating levels of CD34+ cells in patients with PAD and","confidence":1,"confidence_rate":1},{"cnt":[[120,2430],[1998,2430],[1998,2477],[120,2477]],"region":{"top_left_x":120,"top_left_y":2429,"width":1879,"height":49},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bdf5a25f8144a59a58053b0c7418884","type":"text","conversion_output":true,"text":"improves calf muscle perfusion, by promoting neo-angiogenesis, improving endothelial function, and promoting","text_display":" improves calf muscle perfusion, by promoting neo-angiogenesis, improving endothelial function, and promoting","confidence":1,"confidence_rate":1},{"cnt":[[120,2475],[1665,2475],[1665,2520],[120,2520]],"region":{"top_left_x":120,"top_left_y":2475,"width":1546,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf623dc7c987439bb4fc5e9a50d04008","type":"text","conversion_output":true,"text":"vascular repair. Figure 1 shows our proposed theoretical model for our study interventions.","text_display":" vascular repair. Figure 1 shows our proposed theoretical model for our study interventions.","confidence":1,"confidence_rate":1},{"cnt":[[1048,2582],[1079,2582],[1079,2628],[1048,2628]],"region":{"top_left_x":1048,"top_left_y":2582,"width":31,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"092c91d7160341e388eb69e8dd756549","type":"page_info","conversion_output":false,"text":"5","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-06","page":6,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2e3fe27297094e42a626461e78054cd6","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,165],[1738,165]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2b028f99c07d4c1caf09ab4667ae6042","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[419,202],[419,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":299,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f23cbaf0dabb498eb6765cfe62549e93","type":"section_header","conversion_output":false,"children_ids":["03a1034c53424fcd86e3fc328be97c95"],"text":"","text_display":""},{"cnt":[[125,206],[415,206],[415,247],[125,247]],"region":{"top_left_x":124,"top_left_y":206,"width":291,"height":42},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"03a1034c53424fcd86e3fc328be97c95","type":"text","conversion_output":true,"parent_id":"f23cbaf0dabb498eb6765cfe62549e93","text":"B. INNOVATION","text_display":"\n\n\\section*{B. INNOVATION}","confidence":1,"confidence_rate":1},{"cnt":[[125,249],[1923,249],[1923,296],[125,296]],"region":{"top_left_x":124,"top_left_y":249,"width":1799,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c6661639cc1417a8ecebe5874d0b457","type":"text","conversion_output":true,"text":"B1. Innovative features of the proposed PROPEL Study. First, to our knowledge no prior studies have","text_display":"\n\nB1. Innovative features of the proposed PROPEL Study. First, to our knowledge no prior studies have","confidence":0.9956102357245982,"confidence_rate":0.9999576987064488},{"cnt":[[122,296],[1800,296],[1800,339],[122,339]],"region":{"top_left_x":122,"top_left_y":296,"width":1679,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c18b580216049b3bb02ba51aa76875e","type":"text","conversion_output":true,"text":"assessed whether the combination of GM-CSF and supervised treadmill exercise improves walking","text_display":" assessed whether the combination of GM-CSF and supervised treadmill exercise improves walking","confidence":1,"confidence_rate":1},{"cnt":[[125,339],[1974,339],[1974,385],[125,385]],"region":{"top_left_x":124,"top_left_y":339,"width":1851,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"675e7e70e88c47bd926975bdbf0a30a8","type":"text","conversion_output":true,"text":"performance more than GM-CSF alone or supervised treadmill exercise alone in PAD. Yet, experimental and","text_display":" performance more than GM-CSF alone or supervised treadmill exercise alone in PAD. Yet, experimental and","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[125,382],[1914,382],[1914,428],[125,428]],"region":{"top_left_x":124,"top_left_y":382,"width":1791,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0282db18fd074be4ae6c1c70626a673e","type":"text","conversion_output":true,"text":"animal research demonstrate that tissue ischemia and hypoxia, such as that experienced by PAD patients","text_display":" animal research demonstrate that tissue ischemia and hypoxia, such as that experienced by PAD patients","confidence":1,"confidence_rate":1},{"cnt":[[125,425],[1919,425],[1919,471],[125,471]],"region":{"top_left_x":124,"top_left_y":425,"width":1795,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0aa2e669e16f4035b3688b31893a5164","type":"text","conversion_output":true,"text":"during treadmill exercise, promote release of progenitor cells from bone marrow and encourage homing of","text_display":" during treadmill exercise, promote release of progenitor cells from bone marrow and encourage homing of","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[125,473],[1979,473],[1979,518],[125,518]],"region":{"top_left_x":124,"top_left_y":472,"width":1855,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c307f322727349ce87edeba5fca580bf","type":"text","conversion_output":true,"text":"progenitor cells to ischemic sites (37-43). Second, the time course of increases in progenitor cells in response","text_display":" progenitor cells to ischemic sites (37-43). Second, the time course of increases in progenitor cells in response","confidence":0.9522268502041698,"confidence_rate":0.9995816944838398},{"cnt":[[122,516],[1916,516],[1916,561],[122,561]],"region":{"top_left_x":122,"top_left_y":515,"width":1795,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efb892a14c184ab1a790dd120f87f08f","type":"text","conversion_output":true,"text":"to GM-CSF or supervised treadmill exercise among PAD participants is not defined. Although our primary","text_display":" to GM-CSF or supervised treadmill exercise among PAD participants is not defined. Although our primary","confidence":1,"confidence_rate":1},{"cnt":[[125,559],[1949,559],[1949,604],[125,604]],"region":{"top_left_x":124,"top_left_y":558,"width":1825,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fe3bfe947cc48729be6d4172b7cd6b2","type":"text","conversion_output":true,"text":"outcome will be measured at 12 -week follow-up, the PROPEL study will measure changes in CD34+ cells in","text_display":" outcome will be measured at 12 -week follow-up, the PROPEL study will measure changes in CD34+ cells in","confidence":0.9365234375,"confidence_rate":0.9994093571043913},{"cnt":[[125,602],[1906,602],[1906,647],[125,647]],"region":{"top_left_x":124,"top_left_y":601,"width":1782,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07ddf370272940bf8beeca54b5680146","type":"text","conversion_output":true,"text":"response to study interventions at 2 -week, 6 -week, 12 -week, and 6 -month follow-up. Our results will help","text_display":" response to study interventions at 2 -week, 6 -week, 12 -week, and 6 -month follow-up. Our results will help","confidence":0.9970724578015506,"confidence_rate":0.9999765455884029},{"cnt":[[125,645],[1987,645],[1987,690],[125,690]],"region":{"top_left_x":124,"top_left_y":644,"width":1864,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea83a00042ac45f09ce01e92c371f70c","type":"text","conversion_output":true,"text":"define the time-point of maximal improvement and the duration of improvement in study outcomes in response","text_display":" define the time-point of maximal improvement and the duration of improvement in study outcomes in response","confidence":1,"confidence_rate":1},{"cnt":[[122,692],[1944,692],[1944,735],[122,735]],"region":{"top_left_x":122,"top_left_y":691,"width":1823,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a3da55f01464f7d9a7be88f39700736","type":"text","conversion_output":true,"text":"to study interventions and associated increases in progenitor cells. Third, to our knowledge no prior studies","text_display":" to study interventions and associated increases in progenitor cells. Third, to our knowledge no prior studies","confidence":1,"confidence_rate":1},{"cnt":[[125,735],[1949,735],[1949,780],[125,780]],"region":{"top_left_x":124,"top_left_y":734,"width":1825,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a063141de1fd4697b018498e764066e8","type":"text","conversion_output":true,"text":"have directly assessed whether the degree of lower extremity ischemia achieved during treadmill exercise is","text_display":" have directly assessed whether the degree of lower extremity ischemia achieved during treadmill exercise is","confidence":1,"confidence_rate":1},{"cnt":[[125,778],[1927,778],[1927,823],[125,823]],"region":{"top_left_x":124,"top_left_y":777,"width":1804,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0a3f901a85b47418b489fb5cdc8f4db","type":"text","conversion_output":true,"text":"associated with the degree of increase in circulating progenitor cells or the degree of improvement in study","text_display":" associated with the degree of increase in circulating progenitor cells or the degree of improvement in study","confidence":1,"confidence_rate":1},{"cnt":[[122,821],[1966,821],[1966,866],[122,866]],"region":{"top_left_x":122,"top_left_y":820,"width":1844,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b16a253e0c0542de844fdd1cda985759","type":"text","conversion_output":true,"text":"outcomes. We will measure lactate levels during treadmill exercise sessions to establish whether participants","text_display":" outcomes. We will measure lactate levels during treadmill exercise sessions to establish whether participants","confidence":1,"confidence_rate":1},{"cnt":[[122,868],[1923,868],[1923,913],[122,913]],"region":{"top_left_x":122,"top_left_y":867,"width":1801,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"838ad952eaac42c5a8dfcc561994904a","type":"text","conversion_output":true,"text":"who achieve greater increases in lactate during exercise, indicating greater muscle ischemia, have greater","text_display":" who achieve greater increases in lactate during exercise, indicating greater muscle ischemia, have greater","confidence":1,"confidence_rate":1},{"cnt":[[122,911],[1654,911],[1654,956],[122,956]],"region":{"top_left_x":122,"top_left_y":910,"width":1533,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"845ca913aa9d454ebb5850249909e3d8","type":"text","conversion_output":true,"text":"increases in progenitor cells and greater improvement in study outcomes (see section C7).","text_display":" increases in progenitor cells and greater improvement in study outcomes (see section C7).","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[122,999],[2000,999],[2000,1042],[122,1042]],"region":{"top_left_x":122,"top_left_y":999,"width":1879,"height":43},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ddd069801be4d6b8787b45d6810336f","type":"text","conversion_output":true,"text":"B2. Distinctive features of this trial as compared to prior work. We are aware of one ongoing randomized","text_display":"\n\nB2. Distinctive features of this trial as compared to prior work. We are aware of one ongoing randomized","confidence":1,"confidence_rate":1},{"cnt":[[122,1042],[1987,1042],[1987,1087],[122,1087]],"region":{"top_left_x":122,"top_left_y":1041,"width":1866,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2553a0bdcd094d77817bd2e64302473b","type":"text","conversion_output":true,"text":"clinical trial comparing the ability of GM-CSF vs. placebo to improve walking performance in patients with PAD","text_display":" clinical trial comparing the ability of GM-CSF vs. placebo to improve walking performance in patients with PAD","confidence":1,"confidence_rate":1},{"cnt":[[125,1087],[1914,1087],[1914,1132],[125,1132]],"region":{"top_left_x":124,"top_left_y":1087,"width":1791,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2efcef5e0ca4f41af02e6bd199864b5","type":"text","conversion_output":true,"text":"(NCT number NCT0104141). Our proposal has many unique features as compared to this ongoing study.","text_display":" (NCT number NCT0104141). Our proposal has many unique features as compared to this ongoing study.","confidence":1,"confidence_rate":1},{"cnt":[[125,1130],[1968,1130],[1968,1175],[125,1175]],"region":{"top_left_x":124,"top_left_y":1130,"width":1844,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72d7fa92ca774f758135ea53238b3cc6","type":"text","conversion_output":true,"text":"First, our proposal will test whether the combination of GM-CSF and supervised treadmill exercise is superior","text_display":" First, our proposal will test whether the combination of GM-CSF and supervised treadmill exercise is superior","confidence":1,"confidence_rate":1},{"cnt":[[122,1173],[1970,1173],[1970,1218],[122,1218]],"region":{"top_left_x":122,"top_left_y":1173,"width":1849,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"013f947b707b43d79f976ba69ddf8d6e","type":"text","conversion_output":true,"text":"to GM-CSF alone and supervised treadmill exercise alone, respectively, for improving functional performance","text_display":" to GM-CSF alone and supervised treadmill exercise alone, respectively, for improving functional performance","confidence":1,"confidence_rate":1},{"cnt":[[125,1216],[1953,1216],[1953,1261],[125,1261]],"region":{"top_left_x":124,"top_left_y":1216,"width":1829,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dc64b3faf6fe4926ad4766cff4704b64","type":"text","conversion_output":true,"text":"in PAD. Preliminary data support our hypothesis that GM-CSF may be most efficacious when delivered with","text_display":" in PAD. Preliminary data support our hypothesis that GM-CSF may be most efficacious when delivered with","confidence":1,"confidence_rate":1},{"cnt":[[125,1306],[125,1260],[1850,1263],[1850,1309]],"region":{"top_left_x":124,"top_left_y":1260,"width":1726,"height":49},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3150ed0590349a4af318a8539671a35","type":"text","conversion_output":true,"text":"supervised treadmill exercise, but this question is not being addressed by any study to our knowledge.","text_display":" supervised treadmill exercise, but this question is not being addressed by any study to our knowledge.","confidence":1,"confidence_rate":1},{"cnt":[[125,1306],[1940,1306],[1940,1351],[125,1351]],"region":{"top_left_x":124,"top_left_y":1306,"width":1817,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6439da9e521746f0a797d3910a909637","type":"text","conversion_output":true,"text":"Second, by measuring outcomes at six-weeks, 12 -weeks, and six-month follow-up, our proposal will assess","text_display":" Second, by measuring outcomes at six-weeks, 12 -weeks, and six-month follow-up, our proposal will assess","confidence":0.90478515625,"confidence_rate":0.9991070260827025},{"cnt":[[122,1349],[1987,1349],[1987,1394],[122,1394]],"region":{"top_left_x":122,"top_left_y":1349,"width":1866,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7902fd08bc441cd9076c320d143670c","type":"text","conversion_output":true,"text":"the temporal trajectory of favorable changes in response to GM-CSF with and without exercise therapy. Third,","text_display":" the temporal trajectory of favorable changes in response to GM-CSF with and without exercise therapy. Third,","confidence":1,"confidence_rate":1},{"cnt":[[122,1394],[1914,1394],[1914,1437],[122,1437]],"region":{"top_left_x":122,"top_left_y":1394,"width":1793,"height":44},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e822f9f584f4834a60c50057a3c95b0","type":"text","conversion_output":true,"text":"our proposal includes PAD participants both with and without classical intermittent claudication symptoms.","text_display":" our proposal includes PAD participants both with and without classical intermittent claudication symptoms.","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[122,1437],[1833,1437],[1833,1480],[122,1480]],"region":{"top_left_x":122,"top_left_y":1437,"width":1711,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93c1135dc328429291f34f5893ea7dfe","type":"text","conversion_output":true,"text":"This is important because most PAD patients do not have classic intermittent claudication symptoms.","text_display":" This is important because most PAD patients do not have classic intermittent claudication symptoms.","confidence":1,"confidence_rate":1},{"cnt":[[122,1482],[1962,1482],[1962,1528],[122,1528]],"region":{"top_left_x":122,"top_left_y":1482,"width":1840,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf99194121584880a397fe358cb2219a","type":"text","conversion_output":true,"text":"Asymptomatic PAD patients and PAD patients with atypical symptoms have significant functional impairment","text_display":" Asymptomatic PAD patients and PAD patients with atypical symptoms have significant functional impairment","confidence":1,"confidence_rate":1},{"cnt":[[122,1525],[1989,1525],[1989,1571],[122,1571]],"region":{"top_left_x":122,"top_left_y":1525,"width":1868,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6e753174fd242cf9a50e0d6664c248e","type":"text","conversion_output":true,"text":"and faster functional decline than people without PAD ( \\(6,7,51\\) ). Fourth, whether supervised treadmill exercise,","text_display":" and faster functional decline than people without PAD ( \\(6,7,51\\) ). Fourth, whether supervised treadmill exercise,","confidence":0.6979261636734009,"confidence_rate":0.9970074701993531},{"cnt":[[120,1568],[1992,1568],[1992,1613],[120,1613]],"region":{"top_left_x":120,"top_left_y":1568,"width":1872,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6d97d97687b49f3af180bd36e952ff3","type":"text","conversion_output":true,"text":"at the frequency and duration recommended by clinical practice guidelines (35), increases CD34+ cells in PAD","text_display":" at the frequency and duration recommended by clinical practice guidelines (35), increases CD34+ cells in PAD","confidence":0.8489223400374613,"confidence_rate":0.9985516024272761},{"cnt":[[122,1611],[1863,1611],[1863,1656],[122,1656]],"region":{"top_left_x":122,"top_left_y":1611,"width":1741,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c8fa41165334b85b0880a3dac7155de","type":"text","conversion_output":true,"text":"participants is unknown. Our proposal will help establish whether increases in CD34+ cells mediate the","text_display":" participants is unknown. Our proposal will help establish whether increases in CD34+ cells mediate the","confidence":1,"confidence_rate":1},{"cnt":[[120,1659],[1921,1659],[1921,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1658,"width":1801,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62d89a6a72184c31888b1dc18b330861","type":"text","conversion_output":true,"text":"favorable effects of supervised treadmill exercise in PAD. Fifth, we will use the six-minute walk test as our","text_display":" favorable effects of supervised treadmill exercise in PAD. Fifth, we will use the six-minute walk test as our","confidence":1,"confidence_rate":1},{"cnt":[[122,1702],[1944,1702],[1944,1747],[122,1747]],"region":{"top_left_x":122,"top_left_y":1701,"width":1823,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c6d6e802e324ff2b0ce2d1943a34aca","type":"text","conversion_output":true,"text":"primary outcome measure. Our data and that of others demonstrate that the six-minute walk test is a better","text_display":" primary outcome measure. Our data and that of others demonstrate that the six-minute walk test is a better","confidence":1,"confidence_rate":1},{"cnt":[[122,1745],[1936,1745],[1936,1790],[122,1790]],"region":{"top_left_x":122,"top_left_y":1744,"width":1814,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52a3396024c94f50891ccf13589a4329","type":"text","conversion_output":true,"text":"measure of community walking ability than treadmill testing in patients with PAD (see Section C12) (52-54).","text_display":" measure of community walking ability than treadmill testing in patients with PAD (see Section C12) (52-54).","confidence":1,"confidence_rate":1},{"cnt":[[122,1830],[1848,1830],[1848,1876],[122,1876]],"region":{"top_left_x":122,"top_left_y":1830,"width":1726,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48477c310006464687fdd45eb4c62138","type":"text","conversion_output":true,"text":"B3. Additional innovative features. A unique feature of the proposed PROPEL study is the planned","text_display":"\n\nB3. Additional innovative features. A unique feature of the proposed PROPEL study is the planned","confidence":1,"confidence_rate":1},{"cnt":[[122,1878],[1953,1878],[1953,1921],[122,1921]],"region":{"top_left_x":122,"top_left_y":1877,"width":1831,"height":44},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37358c6c7ca74a95b6bd5e380e134fd3","type":"text","conversion_output":true,"text":"comparison in change in walking performance between two interventions that are each expected to increase","text_display":" comparison in change in walking performance between two interventions that are each expected to increase","confidence":1,"confidence_rate":1},{"cnt":[[122,1921],[1968,1921],[1968,1966],[122,1966]],"region":{"top_left_x":122,"top_left_y":1920,"width":1846,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8c8e5d05113c41d19c573e2fc1088d6b","type":"text","conversion_output":true,"text":"circulating CD34+ cells. If supervised treadmill exercise and GM-CSF each increase circulating CD34+ cells,","text_display":" circulating CD34+ cells. If supervised treadmill exercise and GM-CSF each increase circulating CD34+ cells,","confidence":1,"confidence_rate":1},{"cnt":[[120,1964],[1878,1964],[1878,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1758,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11c8d50daa614ab9a40f61d4b81ad504","type":"text","conversion_output":true,"text":"but only the groups receiving supervised treadmill exercise improve walking performance, this result will","text_display":" but only the groups receiving supervised treadmill exercise improve walking performance, this result will","confidence":1,"confidence_rate":1},{"cnt":[[120,2007],[1966,2007],[1966,2052],[120,2052]],"region":{"top_left_x":120,"top_left_y":2006,"width":1846,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7e8614081e84259bf63e7ab945f4965","type":"text","conversion_output":true,"text":"demonstrate that increasing circulating levels of CD34+ cells is not sufficient to improve walking performance","text_display":" demonstrate that increasing circulating levels of CD34+ cells is not sufficient to improve walking performance","confidence":1,"confidence_rate":1},{"cnt":[[120,2052],[1983,2052],[1983,2097],[120,2097]],"region":{"top_left_x":120,"top_left_y":2051,"width":1864,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8057aac904cb491693fd8415d8632493","type":"text","conversion_output":true,"text":"in PAD. Additionally, if supervised exercise alone and GM-CSF alone each improve walking performance, but","text_display":" in PAD. Additionally, if supervised exercise alone and GM-CSF alone each improve walking performance, but","confidence":0.99951171875,"confidence_rate":0.9999955600053285},{"cnt":[[120,2097],[1983,2097],[1983,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2096,"width":1864,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fd6c6c96f3a640618f0ac2351b88ec26","type":"text","conversion_output":true,"text":"their combined benefit does not exceed either intervention alone, this finding would suggest a ceiling effect for","text_display":" their combined benefit does not exceed either intervention alone, this finding would suggest a ceiling effect for","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1962,2140],[1962,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1842,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"667bda7b45f94622b989cdc2854d96b8","type":"text","conversion_output":true,"text":"the ability of interventions that increase CD34+ cells to improve walking performance in PAD. This proposed","text_display":" the ability of interventions that increase CD34+ cells to improve walking performance in PAD. This proposed","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,2185],[1818,2185],[1818,2228],[120,2228]],"region":{"top_left_x":120,"top_left_y":2184,"width":1698,"height":44},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"206bd74c24614e949d57efc3ad8cac86","type":"text","conversion_output":true,"text":"study is expected to identify biological pathways associated with improved functional performance in","text_display":" study is expected to identify biological pathways associated with improved functional performance in","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[122,2226],[1957,2226],[1957,2271],[122,2271]],"region":{"top_left_x":122,"top_left_y":2225,"width":1836,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04d9315e51c44aae81d5002f8767e564","type":"text","conversion_output":true,"text":"participants with PAD. In turn, this information is expected to lead to new therapies to help patients with PAD","text_display":" participants with PAD. In turn, this information is expected to lead to new therapies to help patients with PAD","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[1962,2271],[1962,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1842,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6751f91f4afe4edeb7a3ce136f516fe5","type":"text","conversion_output":true,"text":"improve their functional performance and avoid decline. If our results demonstrate that increasing circulating","text_display":" improve their functional performance and avoid decline. If our results demonstrate that increasing circulating","confidence":1,"confidence_rate":1},{"cnt":[[120,2316],[1936,2316],[1936,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2316,"width":1816,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7467a6f8c1a4f5cbbd1cfeff5f75261","type":"text","conversion_output":true,"text":"levels of CD34+ cells is associated with improved walking performance, then future studies are expected to","text_display":" levels of CD34+ cells is associated with improved walking performance, then future studies are expected to","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,2359],[1916,2359],[1916,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1797,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b13fcf88a844445aa39174cb02eaba0","type":"text","conversion_output":true,"text":"focus on methods that maximize circulating levels of CD34+ cells to improve walking performance in PAD.","text_display":" focus on methods that maximize circulating levels of CD34+ cells to improve walking performance in PAD.","confidence":1,"confidence_rate":1},{"cnt":[[120,2445],[370,2445],[370,2486],[120,2486]],"region":{"top_left_x":120,"top_left_y":2444,"width":250,"height":42},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"629bbc2be2bc465fbf5490d694978e6e","type":"section_header","conversion_output":false,"children_ids":["a7cdbddb5617465db43b0544a4068397"],"text":"","text_display":""},{"cnt":[[125,2449],[367,2449],[367,2484],[125,2484]],"region":{"top_left_x":124,"top_left_y":2449,"width":244,"height":35},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7cdbddb5617465db43b0544a4068397","type":"text","conversion_output":true,"parent_id":"629bbc2be2bc465fbf5490d694978e6e","text":"C. 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METHODS}","confidence":0.98876953125,"confidence_rate":0.999247349608923},{"cnt":[[120,2488],[1085,2488],[1085,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":965,"height":51},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"735e74e542484e1f8ad22509de390ce2","type":"section_header","conversion_output":false,"children_ids":["56fe3d225841419d9f7aed37fd6b856e"],"text":"","text_display":""},{"cnt":[[125,2492],[1081,2492],[1081,2537],[125,2537]],"region":{"top_left_x":124,"top_left_y":2492,"width":957,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56fe3d225841419d9f7aed37fd6b856e","type":"text","conversion_output":true,"parent_id":"735e74e542484e1f8ad22509de390ce2","text":"All data will be collected for research purposes only.","text_display":"\n\n\\section*{All data will be collected for research purposes only.}","confidence":1,"confidence_rate":1},{"cnt":[[1048,2582],[1079,2582],[1079,2628],[1048,2628]],"region":{"top_left_x":1048,"top_left_y":2582,"width":31,"height":46},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a1f7220c8b84697a07cf27563216d0e","type":"page_info","conversion_output":false,"text":"6","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-07","page":7,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a079ff1996d24c78b3f1ba7b634353f5","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,161],[1740,161]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7f66408dd2564cf99d990990d60e5ef2","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1884,206],[1884,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1765,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fcc4a652dd63442da999a6ca47fd9f1b","type":"text","conversion_output":true,"text":"C1a. PRELIMINARY DATA. Our multidisciplinary investigative team includes internationally recognized","text_display":"\n\nC1a. PRELIMINARY DATA. Our multidisciplinary investigative team includes internationally recognized","confidence":1,"confidence_rate":1},{"cnt":[[120,251],[1923,251],[1923,296],[120,296]],"region":{"top_left_x":120,"top_left_y":251,"width":1803,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18ff2d8d8d994d569becccf9a87a5aa9","type":"text","conversion_output":true,"text":"experts in PAD, progenitor cells, exercise training, endothelial function, and functional performance. Since","text_display":" experts in PAD, progenitor cells, exercise training, endothelial function, and functional performance. Since","confidence":1,"confidence_rate":1},{"cnt":[[122,296],[1998,296],[1998,339],[122,339]],"region":{"top_left_x":122,"top_left_y":296,"width":1877,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c97b4274cc44d5387e1a57540c844eb","type":"text","conversion_output":true,"text":"1998, our observational work on functional impairment and decline in PAD has been funded by six R01 awards","text_display":" 1998, our observational work on functional impairment and decline in PAD has been funded by six R01 awards","confidence":0.998046875,"confidence_rate":0.999982387228658},{"cnt":[[120,339],[1953,339],[1953,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1833,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e54861dbee04fb89d6032e04c6f1cb7","type":"text","conversion_output":true,"text":"from the National Heart Lung and Blood Institute (NHLBI), led by Dr. McDermott. Our prior work establishes","text_display":" from the National Heart Lung and Blood Institute (NHLBI), led by Dr. McDermott. Our prior work establishes","confidence":0.99853515625,"confidence_rate":0.9999867936215969},{"cnt":[[120,382],[1919,382],[1919,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1799,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fe92f5728ce41a892dcc6c05f57d644","type":"text","conversion_output":true,"text":"that participants with PAD, both with and without classic symptoms of intermittent claudication, experience","text_display":" that participants with PAD, both with and without classic symptoms of intermittent claudication, experience","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1936,425],[1936,471],[120,471]],"region":{"top_left_x":120,"top_left_y":425,"width":1816,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b56cd39e2dba4a99bd079a51595d5f55","type":"text","conversion_output":true,"text":"significant declines in walking performance over time \\((7,51,55)\\). Even asymptomatic PAD participants have","text_display":" significant declines in walking performance over time \\((7,51,55)\\). Even asymptomatic PAD participants have","confidence":0.57763671875,"confidence_rate":0.9951550480822875},{"cnt":[[120,473],[1972,473],[1972,518],[120,518]],"region":{"top_left_x":120,"top_left_y":472,"width":1853,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99803c98d65247e7856e73a82ff7468b","type":"text","conversion_output":true,"text":"greater impairment in functional performance and faster rates of functional decline compared to those without","text_display":" greater impairment in functional performance and faster rates of functional decline compared to those without","confidence":1,"confidence_rate":1},{"cnt":[[122,516],[1914,516],[1914,561],[122,561]],"region":{"top_left_x":122,"top_left_y":515,"width":1793,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2ffe29e7ad341d8b5e800f8b628f138","type":"text","conversion_output":true,"text":"PAD ( \\(7,51,55-57\\) ). Since 1998, our group has completed more than 75 original research articles on PAD.","text_display":" PAD ( \\(7,51,55-57\\) ). Since 1998, our group has completed more than 75 original research articles on PAD.","confidence":0.9517731228843331,"confidence_rate":0.9995665098709324},{"cnt":[[120,559],[1858,559],[1858,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1739,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b759d723a9594d3c85fee5db2cc8cc2b","type":"text","conversion_output":true,"text":"Three or more of these original research manuscripts have been published in JAMA, Annals of Internal","text_display":" Three or more of these original research manuscripts have been published in JAMA, Annals of Internal","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1910,602],[1910,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1790,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"636e7e1f103b4f07aec3cfb287bf3a98","type":"text","conversion_output":true,"text":"Medicine, Circulation, Journal of the American College of Cardiology, and other widely circulated journals.","text_display":" Medicine, Circulation, Journal of the American College of Cardiology, and other widely circulated journals.","confidence":1,"confidence_rate":1},{"cnt":[[120,692],[1914,692],[1914,735],[120,735]],"region":{"top_left_x":120,"top_left_y":691,"width":1795,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c51458f93747418ab64d789243437cfd","type":"text","conversion_output":true,"text":"Our ability to successfully complete this proposed study is demonstrated in part by our recently completed","text_display":"\n\nOur ability to successfully complete this proposed study is demonstrated in part by our recently completed","confidence":1,"confidence_rate":1},{"cnt":[[120,735],[1886,735],[1886,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1767,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cc168655ae64479ac7ead0066ce3375","type":"text","conversion_output":true,"text":"randomized controlled trial of exercise in PAD participants both with and without intermittent claudication","text_display":" randomized controlled trial of exercise in PAD participants both with and without intermittent claudication","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1876,778],[1876,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1756,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"372b00eb09c646fd9286b68853a99058","type":"text","conversion_output":true,"text":"symptoms (the SILC trial, R01-HL073351) (44). SILC was the first study to test the ability of an exercise","text_display":" symptoms (the SILC trial, R01-HL073351) (44). SILC was the first study to test the ability of an exercise","confidence":0.9990236759185791,"confidence_rate":0.9999911200303706},{"cnt":[[120,821],[1910,821],[1910,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1790,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2b514018bd64b15a1e466c7d89a6d8b","type":"text","conversion_output":true,"text":"intervention to improve walking performance in PAD participants with and without intermittent claudication","text_display":" intervention to improve walking performance in PAD participants with and without intermittent claudication","confidence":1,"confidence_rate":1},{"cnt":[[120,866],[1957,866],[1957,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1838,"height":49},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c627ff384c64aaab493cd4e4e3ed69d","type":"text","conversion_output":true,"text":"symptoms. SILC was also the first randomized controlled trial to test the ability of an exercise intervention to","text_display":" symptoms. SILC was also the first randomized controlled trial to test the ability of an exercise intervention to","confidence":1,"confidence_rate":1},{"cnt":[[120,911],[1968,911],[1968,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1848,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce716c583f6e48419fc09f553bcf4f55","type":"text","conversion_output":true,"text":"increase brachial artery FMD in PAD participants. Results were published in JAMA (44) and are described in","text_display":" increase brachial artery FMD in PAD participants. Results were published in JAMA (44) and are described in","confidence":0.9990234375,"confidence_rate":0.9999911978797494},{"cnt":[[120,954],[1833,954],[1833,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1713,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a1779b9c968467fbde091b11fe0cad6","type":"text","conversion_output":true,"text":"section A7. Mechanisms by which supervised treadmill exercise improves outcomes in PAD are not","text_display":" section A7. Mechanisms by which supervised treadmill exercise improves outcomes in PAD are not","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1893,997],[1893,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1773,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbd584c3d98e445ba96e14b507cded97","type":"text","conversion_output":true,"text":"established. The current proposal builds on our prior work. We will assess whether supervised treadmill","text_display":" established. The current proposal builds on our prior work. We will assess whether supervised treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,1042],[1824,1042],[1824,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1041,"width":1705,"height":47},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9eb63515185c407d8952cbc070d2eeb5","type":"text","conversion_output":true,"text":"exercise increases the ability of GM-CSF to improve walking performance in PAD, establish whether","text_display":" exercise increases the ability of GM-CSF to improve walking performance in PAD, establish whether","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[120,1087],[1876,1087],[1876,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1756,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31594394176e411e92ce4ccdbd47c101","type":"text","conversion_output":true,"text":"supervised treadmill exercise increases circulating CD34+ cells in participants with PAD, and determine","text_display":" supervised treadmill exercise increases circulating CD34+ cells in participants with PAD, and determine","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1996,1130],[1996,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1876,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2556c5d495f4daca9bd84959db8e9a2","type":"text","conversion_output":true,"text":"whether the degree of increase in circulating CD34+ cells correlates with the degree of improvement in walking","text_display":" whether the degree of increase in circulating CD34+ cells correlates with the degree of improvement in walking","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1944,1173],[1944,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1825,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da007edc16e346a9a0b290d5d67c67e6","type":"text","conversion_output":true,"text":"performance and brachial artery FMD in participants with PAD. Our proposed PROPEL study is expected to","text_display":" performance and brachial artery FMD in participants with PAD. Our proposed PROPEL study is expected to","confidence":0.99853515625,"confidence_rate":0.9999862999285899},{"cnt":[[120,1216],[1852,1216],[1852,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1732,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"336204b793f244e18594f047c2c1fc58","type":"text","conversion_output":true,"text":"identify biological pathways associated with improved functional performance in participants with PAD.","text_display":" identify biological pathways associated with improved functional performance in participants with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[120,1302],[1996,1302],[1996,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1876,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac2395b7b8684174a90917980ba12249","type":"text","conversion_output":true,"text":"C1b. Test re-test reliability analysis of progenitor cell measures in our laboratory. In preparation for our","text_display":"\n\nC1b. Test re-test reliability analysis of progenitor cell measures in our laboratory. In preparation for our","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1981,1349],[1981,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1861,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf7c203d11c54249af17467001997ada","type":"text","conversion_output":true,"text":"proposed PROPEL study, we assessed test re-test reliability of our progenitor cell measures. Progenitor cells","text_display":" proposed PROPEL study, we assessed test re-test reliability of our progenitor cell measures. Progenitor cells","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1940,1392],[1940,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1821,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6592550e0f4b4ec6915fd92dba7de517","type":"text","conversion_output":true,"text":"were measured in 29 participants with and without PAD on two separate days, \\(1-2\\) weeks apart. Progenitor","text_display":" were measured in 29 participants with and without PAD on two separate days, \\(1-2\\) weeks apart. Progenitor","confidence":0.96044921875,"confidence_rate":0.9996460787171086},{"cnt":[[120,1435],[1843,1435],[1843,1482],[120,1482]],"region":{"top_left_x":120,"top_left_y":1435,"width":1724,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0460653e9bf042bdb1ea0d6f4fc6ee71","type":"text","conversion_output":true,"text":"cells were measured in Dr. Douglas Losordo's laboratory at Northwestern. Table 3 shows our results.","text_display":" cells were measured in Dr. Douglas Losordo's laboratory at Northwestern. Table 3 shows our results.","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[120,1560],[1815,1560],[1815,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1559,"width":1696,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"950a544353f641109f171abf030880f2","type":"figure_label","conversion_output":false,"text":"Table 3. Results of test re-test reliability analysis for progenitor cell measures in our laboratory ( \\(n = 2 9\\) )","text_display":"","confidence":0.9912149906158447,"confidence_rate":0.9999299720943133},{"cnt":[[120,1594],[1927,1594],[1927,1766],[120,1766]],"region":{"top_left_x":120,"top_left_y":1594,"width":1808,"height":173},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd836ec7882f488fa42ac3c4c98cbbae","type":"table","conversion_output":true,"selected_labels":["950a544353f641109f171abf030880f2"],"text":"\\begin{tabular}{|llll|}\n\\hline Test & CD34+ & ALDH+ & CD34+/CD133+ \\\\\n\\hline Mean value (cells/ml) & 635.3 & 812.0 & 509.4 \\\\\nIntra-pair standard deviation & 72.8 & 75.2 & 60.7 \\\\\nTechnical Error (\\%) & 11.46 & 9.26 & 11.91 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 3. Results of test re-test reliability analysis for progenitor cell measures in our laboratory ( \\(n = 2 9\\) )}\n\\begin{tabular}{|llll|}\n\\hline Test & CD34+ & ALDH+ & CD34+/CD133+ \\\\\n\\hline Mean value (cells/ml) & 635.3 & 812.0 & 509.4 \\\\\nIntra-pair standard deviation & 72.8 & 75.2 & 60.7 \\\\\nTechnical Error (\\%) & 11.46 & 9.26 & 11.91 \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.6268990849079614,"confidence_rate":0.9980063928695155},{"cnt":[[120,1766],[1884,1766],[1884,1811],[120,1811]],"region":{"top_left_x":120,"top_left_y":1766,"width":1765,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f9a49a57feb4d7692e147fb8564d81b","type":"text","conversion_output":true,"text":"Table 3 results demonstrate excellent test re-test reliability of progenitor cell measures in our laboratory.","text_display":"\n\nTable 3 results demonstrate excellent test re-test reliability of progenitor cell measures in our laboratory.","confidence":1,"confidence_rate":1},{"cnt":[[122,1852],[1835,1852],[1835,1897],[122,1897]],"region":{"top_left_x":122,"top_left_y":1851,"width":1713,"height":47},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc58009aa31c410e89b05a016dfba87e","type":"text","conversion_output":true,"text":"C1c. Associations of progenitor cell levels with six-minute walk performance. We also studied","text_display":"\nC1c. Associations of progenitor cell levels with six-minute walk performance. We also studied","confidence":0.99853515625,"confidence_rate":0.9999850417681765},{"cnt":[[120,1942],[120,1896],[1957,1898],[1957,1944]],"region":{"top_left_x":120,"top_left_y":1895,"width":1838,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31f4657630fc476b805135e92ba1cb31","type":"text","conversion_output":true,"text":"associations of circulating CD34+ cells with six-minute walk test performance among the 19 participants with","text_display":" associations of circulating CD34+ cells with six-minute walk test performance among the 19 participants with","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[120,1942],[1940,1942],[1940,1987],[120,1987]],"region":{"top_left_x":120,"top_left_y":1942,"width":1821,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f21b93aae0d34bb998ff237d82b01641","type":"text","conversion_output":true,"text":"PAD in our pilot study. As shown in Table 4, higher numbers of circulating CD34+ cells are associated with","text_display":" PAD in our pilot study. As shown in Table 4, higher numbers of circulating CD34+ cells are associated with","confidence":1,"confidence_rate":1},{"cnt":[[120,1985],[1373,1985],[1373,2030],[120,2030]],"region":{"top_left_x":120,"top_left_y":1985,"width":1253,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"247e1a6f8fde416f818f027b5f986623","type":"text","conversion_output":true,"text":"greater distance achieved in the six-minute walk among PAD participants.","text_display":" greater distance achieved in the six-minute walk among PAD participants.","confidence":1,"confidence_rate":1},{"cnt":[[148,2024],[1972,2024],[1972,2112],[148,2112]],"region":{"top_left_x":148,"top_left_y":2023,"width":1825,"height":89},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8fd65117e3f4e70804d09a282c33ca5","type":"figure_label","conversion_output":false,"children_ids":["7980d71d7237407bb2eb6d67ab9ca456","392d709d469045b292fa0e8dd6e22bdc"],"text":"","text_display":""},{"cnt":[[155,2028],[1970,2028],[1970,2071],[155,2071]],"region":{"top_left_x":154,"top_left_y":2028,"width":1817,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7980d71d7237407bb2eb6d67ab9ca456","type":"text","conversion_output":false,"parent_id":"a8fd65117e3f4e70804d09a282c33ca5","text":"Table 4. Associations of circulating progenitor cell concentrations with six-minute walk distance among PAD","text_display":"","confidence":0.9990236759185791,"confidence_rate":0.9999912786005654},{"cnt":[[752,2067],[1373,2067],[1373,2110],[752,2110]],"region":{"top_left_x":751,"top_left_y":2066,"width":622,"height":44},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"392d709d469045b292fa0e8dd6e22bdc","type":"text","conversion_output":false,"parent_id":"a8fd65117e3f4e70804d09a282c33ca5","text":"participants in our pilot study ( \\(n = 1 9 )^{*}\\)","text_display":"","confidence":0.2656977803055366,"confidence_rate":0.9781522661821707},{"cnt":[[120,2103],[1974,2103],[1974,2237],[120,2237]],"region":{"top_left_x":120,"top_left_y":2103,"width":1855,"height":134},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfffd2de742e4135a18f728fe4ab531e","type":"table","conversion_output":true,"selected_labels":["a8fd65117e3f4e70804d09a282c33ca5"],"text":"\\begin{tabular}{|lll|}\n\\hline & Correlation Coefficient with six-minute walk & P Value \\\\\n\\hline CD34+ cell concentration & 0.44 & 0.06 \\\\\nCD34+/CD133+ cell concentration & 0.38 & 0.11 \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 4. Associations of circulating progenitor cell concentrations with six-minute walk distance among PAD participants in our pilot study ( \\(n = 1 9 )^{*}\\)}\n\\begin{tabular}{|lll|}\n\\hline & Correlation Coefficient with six-minute walk & P Value \\\\\n\\hline CD34+ cell concentration & 0.44 & 0.06 \\\\\nCD34+/CD133+ cell concentration & 0.38 & 0.11 \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.9419779507443309,"confidence_rate":0.9996734226738739},{"cnt":[[120,2234],[844,2234],[844,2275],[120,2275]],"region":{"top_left_x":120,"top_left_y":2234,"width":725,"height":42},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b72bed5eb6bb4ebd908696a16dd75c35","type":"text","conversion_output":true,"text":"*Excludes pilot study participants without PAD.","text_display":"\n*Excludes pilot study participants without PAD.","confidence":0.9751796722412109,"confidence_rate":0.9995167793706387},{"cnt":[[122,2318],[1888,2318],[1888,2361],[122,2361]],"region":{"top_left_x":122,"top_left_y":2318,"width":1767,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af27971a19ea4022ba775bee325cb768","type":"text","conversion_output":true,"text":"In addition, among the 19 PAD participants, six-minute walk distance across tertiles of CD34+ cells were","text_display":"\nIn addition, among the 19 PAD participants, six-minute walk distance across tertiles of CD34+ cells were","confidence":1,"confidence_rate":1},{"cnt":[[120,2361],[1996,2361],[1996,2408],[120,2408]],"region":{"top_left_x":120,"top_left_y":2361,"width":1876,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15adce10ab7c46e4a7f5c62097477f51","type":"text","conversion_output":true,"text":"Tertile 1 (fewest CD34+ cells): 1,063 feet ± 438; Tertile 2: 1,306 feet ± 347; Tertile 3 (largest number of CD34+","text_display":" Tertile 1 (fewest CD34+ cells): 1,063 feet ± 438; Tertile 2: 1,306 feet ± 347; Tertile 3 (largest number of CD34+","confidence":0.4003125545749775,"confidence_rate":0.9926440460990086},{"cnt":[[120,2406],[1781,2406],[1781,2451],[120,2451]],"region":{"top_left_x":120,"top_left_y":2406,"width":1662,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f44b02286065465c9430fe7ea2273949","type":"text","conversion_output":true,"text":"cells): 1,394 feet \\(\\pm 268\\), p trend \\(=0.18\\). In summary, our preliminary data demonstrate that higher","text_display":" cells): 1,394 feet \\(\\pm 268\\), p trend \\(=0.18\\). In summary, our preliminary data demonstrate that higher","confidence":0.7363042821850555,"confidence_rate":0.9974091939899066},{"cnt":[[120,2449],[1588,2449],[1588,2494],[120,2494]],"region":{"top_left_x":120,"top_left_y":2449,"width":1468,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6704fad75f047bd9632ecd8e2825cfc","type":"text","conversion_output":true,"text":"concentrations of CD34+ cells are associated with better six-minute walk performance.","text_display":" concentrations of CD34+ cells are associated with better six-minute walk performance.","confidence":1,"confidence_rate":1},{"cnt":[[1048,2582],[1079,2582],[1079,2628],[1048,2628]],"region":{"top_left_x":1048,"top_left_y":2582,"width":31,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15ee4d6d5328464b960492a112c592df","type":"page_info","conversion_output":false,"text":"7","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-08","page":8,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fb9a6c578ee49b282c02306c26bd697","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,161],[1740,161]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":34},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f172033e38a54766a176c29de789655c","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1820,206],[1820,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1700,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8020291eb30c4ed29106d1e384e187c2","type":"text","conversion_output":true,"text":"C1d. Additional evidence of our expertise with progenitor cells and PAD. Dr. Losordo recently","text_display":"\n\nC1d. Additional evidence of our expertise with progenitor cells and PAD. Dr. Losordo recently","confidence":1,"confidence_rate":1},{"cnt":[[120,251],[1798,251],[1798,294],[120,294]],"region":{"top_left_x":120,"top_left_y":251,"width":1679,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b11ee8161d4469cb1f1c1ec8a936369","type":"text","conversion_output":true,"text":"completed a randomized controlled trial of 28 PAD participants with critical limb ischemia who were","text_display":" completed a randomized controlled trial of 28 PAD participants with critical limb ischemia who were","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[120,296],[1940,296],[1940,339],[120,339]],"region":{"top_left_x":120,"top_left_y":296,"width":1821,"height":44},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"537dc829dd694cfc8bcb7f4b462245d5","type":"text","conversion_output":true,"text":"randomized to either a control group vs. CD34+ cell mobilization, apheresis, and re-injection of CD34+ cells","text_display":" randomized to either a control group vs. CD34+ cell mobilization, apheresis, and re-injection of CD34+ cells","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1863,339],[1863,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1743,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b307dc37d044bd8a855ba9b01dcbc50","type":"text","conversion_output":true,"text":"into calf muscle. At six-month follow-up, amputation-free survival was significantly higher among those","text_display":" into calf muscle. At six-month follow-up, amputation-free survival was significantly higher among those","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[2002,382],[2002,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1883,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86a807aadeee45fc80269b4bb46dbed0","type":"text","conversion_output":true,"text":"receiving CD34+ cell calf injections as compared to the control group (hazard ratio \\(=0.26, p =0.016\\) ). This study","text_display":" receiving CD34+ cell calf injections as compared to the control group (hazard ratio \\(=0.26, p =0.016\\) ). This study","confidence":0.8906580328777225,"confidence_rate":0.9990513131843282},{"cnt":[[120,425],[1803,425],[1803,471],[120,471]],"region":{"top_left_x":120,"top_left_y":425,"width":1683,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f365018a93494edfa536a6f298a0e673","type":"text","conversion_output":true,"text":"provides additional evidence of our expertise and the benefits of CD34+ cells for patients with PAD.","text_display":" provides additional evidence of our expertise and the benefits of CD34+ cells for patients with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[122,516],[1914,516],[1914,561],[122,561]],"region":{"top_left_x":122,"top_left_y":515,"width":1793,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cae9ec154e9843a4a7eeab82b014c054","type":"text","conversion_output":true,"text":"Preliminary Data Summary. Our prior work has established that people with PAD, both with and without","text_display":"\n\nPreliminary Data Summary. Our prior work has established that people with PAD, both with and without","confidence":1,"confidence_rate":1},{"cnt":[[122,559],[1946,559],[1946,604],[122,604]],"region":{"top_left_x":122,"top_left_y":558,"width":1825,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0da208b000904d1184365a67488a1d91","type":"text","conversion_output":true,"text":"intermittent claudication symptoms, have greater functional impairment and faster rates of functional decline","text_display":" intermittent claudication symptoms, have greater functional impairment and faster rates of functional decline","confidence":1,"confidence_rate":1},{"cnt":[[120,604],[1936,604],[1936,647],[120,647]],"region":{"top_left_x":120,"top_left_y":603,"width":1816,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26ad7b3560234e1da6fef1576a104123","type":"text","conversion_output":true,"text":"compared to those without PAD ( \\(6-8,51,55-57\\) ). Our SILC randomized trial of exercise demonstrated that a","text_display":" compared to those without PAD ( \\(6-8,51,55-57\\) ). Our SILC randomized trial of exercise demonstrated that a","confidence":0.898047924041748,"confidence_rate":0.9990488433924686},{"cnt":[[120,647],[1921,647],[1921,690],[120,690]],"region":{"top_left_x":120,"top_left_y":646,"width":1801,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11090847e6c4459ea1948a5301e810e8","type":"text","conversion_output":true,"text":"supervised treadmill walking exercise intervention significantly improves walking performance and brachial","text_display":" supervised treadmill walking exercise intervention significantly improves walking performance and brachial","confidence":1,"confidence_rate":1},{"cnt":[[120,692],[1949,692],[1949,735],[120,735]],"region":{"top_left_x":120,"top_left_y":691,"width":1829,"height":44},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"412247ac7e0947c98ff2dee3cfcd0a7e","type":"text","conversion_output":true,"text":"artery flow-mediated dilation in PAD participants both with and without symptoms of intermittent claudication","text_display":" artery flow-mediated dilation in PAD participants both with and without symptoms of intermittent claudication","confidence":1,"confidence_rate":1},{"cnt":[[122,735],[1972,735],[1972,780],[122,780]],"region":{"top_left_x":122,"top_left_y":734,"width":1851,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df63e88d37824b7c9d1e2352422a15d5","type":"text","conversion_output":true,"text":"(44). Our pilot data demonstrate that higher concentrations of CD34+ cells are associated with better walking","text_display":" (44). Our pilot data demonstrate that higher concentrations of CD34+ cells are associated with better walking","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1983,778],[1983,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1864,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f0270901af34551a69b22ad189ad01e","type":"text","conversion_output":true,"text":"performance in PAD. Our preliminary work demonstrates the validity, reliability, and feasibility of our methods.","text_display":" performance in PAD. Our preliminary work demonstrates the validity, reliability, and feasibility of our methods.","confidence":0.99755859375,"confidence_rate":0.9999791079845508},{"cnt":[[120,911],[120,864],[1803,866],[1803,913]],"region":{"top_left_x":120,"top_left_y":863,"width":1683,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bce20ed2b764db89ee4700b4aa9864e","type":"text","conversion_output":true,"text":"C2. STUDY OVERVIEW. The PROPEL study design is a randomized controlled clinical trial of 240","text_display":"\n\nC2. STUDY OVERVIEW. The PROPEL study design is a randomized controlled clinical trial of 240","confidence":0.99951171875,"confidence_rate":0.9999949125077526},{"cnt":[[120,911],[1938,911],[1938,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1818,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d64e22468c24dbf856faebec6a3795a","type":"text","conversion_output":true,"text":"participants with PAD who will be randomized to one of four study arms in a \\(2 \\times 2\\) factorial design: Group A:","text_display":" participants with PAD who will be randomized to one of four study arms in a \\(2 \\times 2\\) factorial design: Group A:","confidence":0.9941518236882985,"confidence_rate":0.9999485509388109},{"cnt":[[122,954],[1886,954],[1886,999],[122,999]],"region":{"top_left_x":122,"top_left_y":953,"width":1765,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8994dd69ed1d4485b90900d7a251fcfb","type":"text","conversion_output":true,"text":"GM-CSF and supervised treadmill exercise; Group B: GM-CSF and attention control condition; Group C:","text_display":" GM-CSF and supervised treadmill exercise; Group B: GM-CSF and attention control condition; Group C:","confidence":1,"confidence_rate":1},{"cnt":[[120,999],[1854,999],[1854,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":999,"width":1735,"height":43},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55626fbfd1c449e88e651ae5e8698651","type":"text","conversion_output":true,"text":"placebo injections and supervised treadmill exercise; Group D: placebo injections and attention control","text_display":" placebo injections and supervised treadmill exercise; Group D: placebo injections and attention control","confidence":0.99853515625,"confidence_rate":0.999986426780242},{"cnt":[[122,1042],[1897,1042],[1897,1087],[122,1087]],"region":{"top_left_x":122,"top_left_y":1041,"width":1776,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08a3b03b07bd42ee915bb128269b7cf4","type":"text","conversion_output":true,"text":"condition (Figure 2). Potentially eligible participants will be required to successfully complete a two-week","text_display":" condition (Figure 2). Potentially eligible participants will be required to successfully complete a two-week","confidence":1,"confidence_rate":1},{"cnt":[[120,1087],[1972,1087],[1972,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1853,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3113b74cd1394c92b9a4ee3225220201","type":"text","conversion_output":true,"text":"combined exercise/attention control run-in period prior to randomization. The run-in will help identify potential","text_display":" combined exercise/attention control run-in period prior to randomization. The run-in will help identify potential","confidence":1,"confidence_rate":1},{"cnt":[[122,1130],[1098,1130],[1098,1175],[122,1175]],"region":{"top_left_x":122,"top_left_y":1130,"width":976,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"018f1057ceb046c893cbbb1b04d57f96","type":"text","conversion_output":true,"text":"participants unlikely to adhere to study requirements (58).","text_display":" participants unlikely to adhere to study requirements (58).","confidence":1,"confidence_rate":1},{"cnt":[[122,1171],[2000,1171],[2000,1502],[122,1502]],"region":{"top_left_x":122,"top_left_y":1170,"width":1879,"height":332},"line":23,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"ae4beff4e0594dd9bcf0c4136b5e30bc","type":"diagram","conversion_output":true,"selected_labels":["aefd8c35071c4de0867d395959177847","c443598b810b4f35abea18f773e08ef6"],"text":"","text_display":"\n\n\\begin{figure}\n\\includegraphics[alt={},max width=\\textwidth]{https://cdn.mathpix.com/cropped/e63f6bd9-8a76-4101-acf6-184b5e738ce4-08.jpg?height=332&width=1879&top_left_y=1170&top_left_x=122}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5 summarizes characteristics of the four study intervention groups.}\n\\end{figure}"},{"cnt":[[120,1508],[1356,1508],[1356,1553],[120,1553]],"region":{"top_left_x":120,"top_left_y":1508,"width":1236,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aefd8c35071c4de0867d395959177847","type":"figure_label","conversion_output":false,"text":"Table 5 summarizes characteristics of the four study intervention groups.","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[842,1551],[1278,1551],[1278,1592],[842,1592]],"region":{"top_left_x":842,"top_left_y":1551,"width":437,"height":41},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c443598b810b4f35abea18f773e08ef6","type":"figure_label","conversion_output":false,"text":"Table 5. Four Study Arms","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[99,1586],[2024,1586],[2024,1798],[99,1798]],"region":{"top_left_x":98,"top_left_y":1585,"width":1926,"height":214},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e2a488a76ef47a2b3851b4474418e8d","type":"table","conversion_output":true,"selected_labels":["c443598b810b4f35abea18f773e08ef6"],"text":"\\begin{tabular}{|lcl|}\n\\hline & \\multicolumn{1}{c}{ Supervised Treadmill Exercise } & \\multicolumn{1}{c|}{ Attention Control Condition } \\\\\n\\hline GM-CSF & Group A. GM-CSF injections \\(\\times 2\\) weeks + & Group B. GM-CSF injections \\(\\times 2\\) weeks + \\\\\n& Supervised treadmill exercise \\(\\times 6\\) months & Attention control condition \\(\\times 6\\) months. \\\\\nPlacebo & Group C. Placebo injections \\(\\times 2\\) weeks + & Group D. Placebo injections \\(\\times 2\\) weeks + \\\\\n& Supervised treadmill exercise \\(\\times 6\\) months. & Attention control condition \\(\\times 6\\) months. \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 5. Four Study Arms}\n\\begin{tabular}{|lcl|}\n\\hline & \\multicolumn{1}{c}{ Supervised Treadmill Exercise } & \\multicolumn{1}{c|}{ Attention Control Condition } \\\\\n\\hline GM-CSF & Group A. GM-CSF injections \\(\\times 2\\) weeks + & Group B. GM-CSF injections \\(\\times 2\\) weeks + \\\\\n& Supervised treadmill exercise \\(\\times 6\\) months & Attention control condition \\(\\times 6\\) months. \\\\\nPlacebo & Group C. Placebo injections \\(\\times 2\\) weeks + & Group D. Placebo injections \\(\\times 2\\) weeks + \\\\\n& Supervised treadmill exercise \\(\\times 6\\) months. & Attention control condition \\(\\times 6\\) months. \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.20128021143609995,"confidence_rate":0.9969685109843677},{"cnt":[[120,1796],[1940,1796],[1940,1841],[120,1841]],"region":{"top_left_x":120,"top_left_y":1796,"width":1821,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f396382ffe6845b58a7e55b3c6df991f","type":"text","conversion_output":true,"text":"Table 6 shows the data collection planned at each time point. Our primary outcome is change in six-minute","text_display":"\n\nTable 6 shows the data collection planned at each time point. Our primary outcome is change in six-minute","confidence":1,"confidence_rate":1},{"cnt":[[120,1839],[1139,1839],[1139,1884],[120,1884]],"region":{"top_left_x":120,"top_left_y":1839,"width":1019,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"471ba784ae5c40908ec502e6473f4b55","type":"text","conversion_output":true,"text":"walk performance between baseline and 12-week follow-up.","text_display":" walk performance between baseline and 12-week follow-up.","confidence":0.960956335067749,"confidence_rate":0.999347322791109},{"cnt":[[614,1921],[1506,1921],[1506,1966],[614,1966]],"region":{"top_left_x":614,"top_left_y":1920,"width":893,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e3eb487150d49208245b88d825229f0","type":"figure_label","conversion_output":false,"text":"Table 6. Data Collection Schedule for PROPEL Study","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,1959],[2022,1959],[2022,2211],[120,2211]],"region":{"top_left_x":120,"top_left_y":1959,"width":1902,"height":252},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e4bb516524b49feaced68918c1ba6b4","type":"table","conversion_output":true,"selected_labels":["9e3eb487150d49208245b88d825229f0"],"text":"\\begin{tabular}{|llllll|}\n\\hline & Baseline & \\begin{tabular}{l} \nTwo-week \\\\\nfollow-up\n\\end{tabular} & \\begin{tabular}{l} \nSix-week \\\\\nfollow-up\n\\end{tabular} & \\begin{tabular}{l} \nTwelve week \\\\\nfollow-up*\n\\end{tabular} & \\begin{tabular}{l} \nSix-month \\\\\nfollow-up\n\\end{tabular} \\\\\n\\hline Six-minute walk. & X & & X & X & X \\\\\nCD34+ cells and other progenitor cell measures & X & X & X & X & X \\\\\nBrachial artery flow-mediated dilation. & X & & X & X & X \\\\\nTreadmill walking performance. & X & & X & X & X \\\\\n\\hline\n\\end{tabular}","text_display":"\n\n\\begin{table}\n\\captionsetup{labelformat=empty}\n\\caption{Table 6. Data Collection Schedule for PROPEL Study}\n\\begin{tabular}{|llllll|}\n\\hline & Baseline & \\begin{tabular}{l} \nTwo-week \\\\\nfollow-up\n\\end{tabular} & \\begin{tabular}{l} \nSix-week \\\\\nfollow-up\n\\end{tabular} & \\begin{tabular}{l} \nTwelve week \\\\\nfollow-up*\n\\end{tabular} & \\begin{tabular}{l} \nSix-month \\\\\nfollow-up\n\\end{tabular} \\\\\n\\hline Six-minute walk. & X & & X & X & X \\\\\nCD34+ cells and other progenitor cell measures & X & X & X & X & X \\\\\nBrachial artery flow-mediated dilation. & X & & X & X & X \\\\\nTreadmill walking performance. & X & & X & X & X \\\\\n\\hline\n\\end{tabular}\n\\end{table}","confidence":0.8875622186122364,"confidence_rate":0.9997575971594975},{"cnt":[[116,2204],[892,2204],[892,2254],[116,2254]],"region":{"top_left_x":116,"top_left_y":2204,"width":776,"height":50},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"20662a16d0ab429ca039a3fc8c52c56a","type":"section_header","conversion_output":false,"children_ids":["83009e2b75844d4a8aa7246ab789b8bb"],"text":"","text_display":""},{"cnt":[[120,2209],[887,2209],[887,2249],[120,2249]],"region":{"top_left_x":120,"top_left_y":2208,"width":768,"height":42},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"83009e2b75844d4a8aa7246ab789b8bb","type":"text","conversion_output":true,"parent_id":"20662a16d0ab429ca039a3fc8c52c56a","text":"*Time point of primary outcome measurement","text_display":"\n\n\\section*{*Time point of primary outcome measurement}","confidence":0.99951171875,"confidence_rate":0.9999896085540316},{"cnt":[[120,2247],[1944,2247],[1944,2292],[120,2292]],"region":{"top_left_x":120,"top_left_y":2247,"width":1825,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b1835e758c8496893220152f81fd56b","type":"text","conversion_output":true,"text":"We have not powered the study to test for an interaction between the two therapies. We are not necessarily","text_display":"\n\nWe have not powered the study to test for an interaction between the two therapies. We are not necessarily","confidence":1,"confidence_rate":1},{"cnt":[[120,2292],[1953,2292],[1953,2338],[120,2338]],"region":{"top_left_x":120,"top_left_y":2292,"width":1833,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef00678044924bec9d79715999e88018","type":"text","conversion_output":true,"text":"looking for more than an additive benefit of GM-CSF with supervised treadmill exercise as compared to GM-","text_display":" looking for more than an additive benefit of GM-CSF with supervised treadmill exercise as compared to GM","confidence":1,"confidence_rate":1},{"cnt":[[120,2338],[1974,2338],[1974,2383],[120,2383]],"region":{"top_left_x":120,"top_left_y":2337,"width":1855,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7fb134b1f71d4ebf89e8874612a26ab3","type":"text","conversion_output":true,"text":"CSF alone and supervised treadmill exercise alone. This is because any additional significant improvement in","text_display":"CSF alone and supervised treadmill exercise alone. This is because any additional significant improvement in","confidence":1,"confidence_rate":1},{"cnt":[[120,2380],[1970,2380],[1970,2426],[120,2426]],"region":{"top_left_x":120,"top_left_y":2380,"width":1851,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32cf58bd42b5457690e6d8e552b84fdd","type":"text","conversion_output":true,"text":"walking performance from combining GM-CSF and supervised treadmill exercise, compared to either therapy","text_display":" walking performance from combining GM-CSF and supervised treadmill exercise, compared to either therapy","confidence":1,"confidence_rate":1},{"cnt":[[120,2426],[1197,2426],[1197,2469],[120,2469]],"region":{"top_left_x":120,"top_left_y":2425,"width":1077,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30659493abf747289f9cab85f81c23e6","type":"text","conversion_output":true,"text":"alone, will have significant clinical implications for PAD therapy.","text_display":" alone, will have significant clinical implications for PAD therapy.","confidence":1,"confidence_rate":1},{"cnt":[[1051,2582],[1079,2582],[1079,2628],[1051,2628]],"region":{"top_left_x":1050,"top_left_y":2582,"width":29,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed7e38c3915342b087df9f51ff70a9a1","type":"page_info","conversion_output":false,"text":"8","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-09","page":9,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8707be198aa44135acff394539dd3334","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,163],[1740,163]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"36b3f04a1fe34f8caa2dd71be5b85631","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1983,206],[1983,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1864,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"958279f0c0f64ec48d9604dce677c3c9","type":"text","conversion_output":true,"text":"C3. Inclusion Criteria. All participants will have PAD. PAD will be defined as follows. First, an \\(ABI \\leq 0.90\\) at","text_display":"\n\nC3. Inclusion Criteria. All participants will have PAD. PAD will be defined as follows. First, an \\(ABI \\leq 0.90\\) at","confidence":0.9936623573303223,"confidence_rate":0.9999470196469723},{"cnt":[[120,249],[1927,249],[1927,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1808,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4360affc3ebd42648d8f937d7fc8e738","type":"text","conversion_output":true,"text":"the baseline study visit is an inclusion criterion for PAD (60-63). ABI \\(\\leq 0.90\\) is a well accepted standard for","text_display":" the baseline study visit is an inclusion criterion for PAD (60-63). ABI \\(\\leq 0.90\\) is a well accepted standard for","confidence":0.9936628304421902,"confidence_rate":0.9999456652825514},{"cnt":[[120,294],[1996,294],[1996,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1876,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0af818ca9067468eb1fa0112678e8976","type":"text","conversion_output":true,"text":"defining PAD (60-63). Second, potential participants who have an ABI \\(>0.90\\) but \\(\\leq 1.00\\) and experience a \\(20 \\%\\)","text_display":" defining PAD (60-63). Second, potential participants who have an ABI \\(>0.90\\) but \\(\\leq 1.00\\) and experience a \\(20 \\%\\)","confidence":0.5868553002364933,"confidence_rate":0.9953761405248329},{"cnt":[[120,339],[1987,339],[1987,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1868,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"416cde1a1c3741b9a49b45acef26b748","type":"text","conversion_output":true,"text":"drop in ABI after the heel-rise exercise will be eligible. Third, potential participants who have an \\(ABI >0.90\\) but","text_display":" drop in ABI after the heel-rise exercise will be eligible. Third, potential participants who have an \\(ABI >0.90\\) but","confidence":0.7589089858811349,"confidence_rate":0.9977776873402101},{"cnt":[[120,382],[1953,382],[1953,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1833,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35fa1d4dac754eb7a9ce91aa990bf07f","type":"text","conversion_output":true,"text":"have a documented lower extremity revascularization procedure and experience a \\(20 \\%\\) drop in ABI after the","text_display":" have a documented lower extremity revascularization procedure and experience a \\(20 \\%\\) drop in ABI after the","confidence":0.93896484375,"confidence_rate":0.9994378612684046},{"cnt":[[120,425],[1897,425],[1897,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1778,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e1c0471754e74d53b976b1a99b299152","type":"text","conversion_output":true,"text":"heel-rise exercise will be eligible. Fourth, potential participants with an ABI \\(>0.90\\) who have vascular lab","text_display":" heel-rise exercise will be eligible. Fourth, potential participants with an ABI \\(>0.90\\) who have vascular lab","confidence":0.740234375,"confidence_rate":0.9973878660966158},{"cnt":[[120,473],[668,473],[668,518],[120,518]],"region":{"top_left_x":120,"top_left_y":472,"width":549,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8c57caf48bc47e89933952ef7b69a4c","type":"text","conversion_output":true,"text":"evidence of PAD will be eligible.","text_display":" evidence of PAD will be eligible.","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1970,516],[1970,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1851,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df6140ef390e45bb97aaa27b007e84f8","type":"text","conversion_output":true,"text":"C4. Exclusion Criteria. Exclusion criteria and justification for each criterion follow. 1. Potential participants","text_display":"\nC4. Exclusion Criteria. Exclusion criteria and justification for each criterion follow. 1. Potential participants","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1970,559],[1970,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1851,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a90cd372195f4a13b0ef6cb7cabcba6c","type":"text","conversion_output":true,"text":"with below or above-knee amputation or critical limb ischemia, those who are wheelchair confined, those who","text_display":" with below or above-knee amputation or critical limb ischemia, those who are wheelchair confined, those who","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1936,602],[1936,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1816,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c23ef0be7c7494787d27d99f3b2d030","type":"text","conversion_output":true,"text":"use a walking aid other than a cane (i.e. people using walkers), those who are non-English speaking, those","text_display":" use a walking aid other than a cane (i.e. people using walkers), those who are non-English speaking, those","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,645],[1899,645],[1899,690],[120,690]],"region":{"top_left_x":120,"top_left_y":644,"width":1780,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53642e87dad34793ad5da43dea660020","type":"text","conversion_output":true,"text":"with significant hearing or visual impairment, and those unable to return to the medical center three times","text_display":" with significant hearing or visual impairment, and those unable to return to the medical center three times","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1910,690],[1910,735],[120,735]],"region":{"top_left_x":120,"top_left_y":689,"width":1790,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0702f42d16084f648c7f8a33f946ea5d","type":"text","conversion_output":true,"text":"weekly will be excluded because these individuals will not be able to participate fully in our intervention; 2 .","text_display":" weekly will be excluded because these individuals will not be able to participate fully in our intervention; 2 .","confidence":0.99951171875,"confidence_rate":0.9999959300041316},{"cnt":[[122,735],[1863,735],[1863,780],[122,780]],"region":{"top_left_x":122,"top_left_y":734,"width":1741,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d17f5ee9377446b861d1b22d5d0d244","type":"text","conversion_output":true,"text":"Potential participants diagnosed with Parkinson's disease and individuals whose walking is limited by a","text_display":" Potential participants diagnosed with Parkinson's disease and individuals whose walking is limited by a","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[120,778],[1906,778],[1906,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1786,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b6b916772444b618105975d823d9cfb","type":"text","conversion_output":true,"text":"symptom other than PAD will be excluded because our intervention is designed specifically for individuals","text_display":" symptom other than PAD will be excluded because our intervention is designed specifically for individuals","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1974,821],[1974,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1855,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cb9e2755a74408eb0f530f9da0aca33","type":"text","conversion_output":true,"text":"whose walking is limited by leg ischemia. 3. Potential participants with > Class II New York Heart Association","text_display":" whose walking is limited by leg ischemia. 3. Potential participants with > Class II New York Heart Association","confidence":0.9990236759185791,"confidence_rate":0.999991506114367},{"cnt":[[120,866],[1962,866],[1962,911],[120,911]],"region":{"top_left_x":120,"top_left_y":865,"width":1842,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7008a50605d41159d539184005f753a","type":"text","conversion_output":true,"text":"heart failure or angina, an increase in angina symptoms during the previous 6 months, angina at rest, severe","text_display":" heart failure or angina, an increase in angina symptoms during the previous 6 months, angina at rest, severe","confidence":1,"confidence_rate":1},{"cnt":[[120,911],[1957,911],[1957,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1838,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b7d20535771482a8247ee23aed44ea5","type":"text","conversion_output":true,"text":"aortic stenosis, coronary ischemia during the baseline exercise treadmill test, those with a left-bundle branch","text_display":" aortic stenosis, coronary ischemia during the baseline exercise treadmill test, those with a left-bundle branch","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1987,954],[1987,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1868,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e342dae9d684e0d90c5cee5c7b8431a","type":"text","conversion_output":true,"text":"block or significant ST-T wave changes on the baseline ECG precluding interpretation of the baseline exercise","text_display":" block or significant ST-T wave changes on the baseline ECG precluding interpretation of the baseline exercise","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1989,997],[1989,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1870,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7298085c2839405caf419e213da1d373","type":"text","conversion_output":true,"text":"treadmill test, those who stop during the treadmill stress test for shortness of breath, chest pain, hip pain, knee","text_display":" treadmill test, those who stop during the treadmill stress test for shortness of breath, chest pain, hip pain, knee","confidence":1,"confidence_rate":1},{"cnt":[[122,1042],[2004,1042],[2004,1087],[122,1087]],"region":{"top_left_x":122,"top_left_y":1041,"width":1883,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"929486975a734b83aab7d902adb4745d","type":"text","conversion_output":true,"text":"pain, or another symptom that may not represent ischemic leg pain, stopping during the six-minute walk test for","text_display":" pain, or another symptom that may not represent ischemic leg pain, stopping during the six-minute walk test for","confidence":1,"confidence_rate":1},{"cnt":[[120,1087],[1985,1087],[1985,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1866,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1330d47d514c4d67b6ad80d959d85592","type":"text","conversion_output":true,"text":"symptoms other than ischemic leg pain, or a foot ulcer will be excluded because it may not be safe for them to","text_display":" symptoms other than ischemic leg pain, or a foot ulcer will be excluded because it may not be safe for them to","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1987,1130],[1987,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1868,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe1c8ceb1965458885552186a66298b5","type":"text","conversion_output":true,"text":"enter an exercise program. 4. Potential participants who have had lower extremity revascularization during the","text_display":" enter an exercise program. 4. Potential participants who have had lower extremity revascularization during the","confidence":0.98046875,"confidence_rate":0.9998284972704681},{"cnt":[[120,1173],[1944,1173],[1944,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1825,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6dd2e6a048fc43278d3dd60d674717dd","type":"text","conversion_output":true,"text":"past three months, those with major orthopedic surgery during the past three months, those with myocardial","text_display":" past three months, those with major orthopedic surgery during the past three months, those with myocardial","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,1216],[1919,1216],[1919,1261],[120,1261]],"region":{"top_left_x":120,"top_left_y":1216,"width":1799,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dc5b1caedd94d5e801c76f53e81f714","type":"text","conversion_output":true,"text":"infarction, ischemic stroke, or coronary artery bypass grafting during the previous three months, and those","text_display":" infarction, ischemic stroke, or coronary artery bypass grafting during the previous three months, and those","confidence":0.9697265625,"confidence_rate":0.9997255631865103},{"cnt":[[120,1261],[1927,1261],[1927,1306],[120,1306]],"region":{"top_left_x":120,"top_left_y":1261,"width":1808,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2cfca8a4fdf4a21b4bd79f10f87c210","type":"text","conversion_output":true,"text":"contemplating lower extremity revascularization during the next six months will be excluded because these","text_display":" contemplating lower extremity revascularization during the next six months will be excluded because these","confidence":1,"confidence_rate":1},{"cnt":[[120,1306],[1957,1306],[1957,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1306,"width":1838,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"436c0727685a4f82943f9b0c9ac8c7b8","type":"text","conversion_output":true,"text":"events may influence study outcomes, independently of the study interventions; 5. Potential participants with","text_display":" events may influence study outcomes, independently of the study interventions; 5. Potential participants with","confidence":0.97900390625,"confidence_rate":0.9998138800731758},{"cnt":[[120,1349],[1897,1349],[1897,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1778,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e3cbb4815fd4c24a62bb06778b34110","type":"text","conversion_output":true,"text":"major medical illnesses including renal disease requiring dialysis or lung disease requiring oxygen will be","text_display":" major medical illnesses including renal disease requiring dialysis or lung disease requiring oxygen will be","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1914,1392],[1914,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1795,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d800eb093eb2495dbdcb3784680609c2","type":"text","conversion_output":true,"text":"excluded because these and other major medical illnesses may prevent their full participation in the study.","text_display":" excluded because these and other major medical illnesses may prevent their full participation in the study.","confidence":1,"confidence_rate":1},{"cnt":[[122,1437],[1886,1437],[1886,1482],[122,1482]],"region":{"top_left_x":122,"top_left_y":1437,"width":1765,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0a1a06e817949599c42ce9d3a09ead6","type":"text","conversion_output":true,"text":"Participants who use oxygen at night may still qualify. 6. Potential participants with a Mini-Mental Status","text_display":" Participants who use oxygen at night may still qualify. 6. Potential participants with a Mini-Mental Status","confidence":1,"confidence_rate":1},{"cnt":[[120,1480],[1996,1480],[1996,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1876,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b2f95295ce848ffa3dbc3285546425b","type":"text","conversion_output":true,"text":"Examination (MMSE) score < 23 (64) or disabling psychiatric illness will be excluded because these conditions","text_display":" Examination (MMSE) score < 23 (64) or disabling psychiatric illness will be excluded because these conditions","confidence":0.9809749083360657,"confidence_rate":0.9998358391392623},{"cnt":[[120,1525],[1992,1525],[1992,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":1872,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00684346d4814878998e690e2eb71507","type":"text","conversion_output":true,"text":"may prevent their full study participation or ability to provide accurate responses to questionnaires; 7. Potential","text_display":" may prevent their full study participation or ability to provide accurate responses to questionnaires; 7. Potential","confidence":0.9990234375,"confidence_rate":0.9999918580360807},{"cnt":[[120,1568],[1916,1568],[1916,1613],[120,1613]],"region":{"top_left_x":120,"top_left_y":1568,"width":1797,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e500ff7044bd425abe156146c1274ab3","type":"text","conversion_output":true,"text":"participants enrolled in cardiac rehabilitation during the past six months and those who are either currently","text_display":" participants enrolled in cardiac rehabilitation during the past six months and those who are either currently","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[1979,1611],[1979,1659],[120,1659]],"region":{"top_left_x":120,"top_left_y":1611,"width":1859,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e12eafc0383849b194125055c1234fc1","type":"text","conversion_output":true,"text":"enrolled in another clinical trial or who have been enrolled in another clinical trial during the past three months","text_display":" enrolled in another clinical trial or who have been enrolled in another clinical trial during the past three months","confidence":1,"confidence_rate":1},{"cnt":[[120,1659],[1792,1659],[1792,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1658,"width":1672,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3381de7e3f0d4b169b3ad511aba6a0c4","type":"text","conversion_output":true,"text":"will be excluded because these interventions may alter outcome measures, independently of study","text_display":" will be excluded because these interventions may alter outcome measures, independently of study","confidence":1,"confidence_rate":1},{"cnt":[[120,1702],[2000,1702],[2000,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1701,"width":1881,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd75972bcee049adb8f5af505761ad6e","type":"text","conversion_output":true,"text":"interventions. However, for a clinical trial of stem cell or gene therapy intervention, potential participants will be","text_display":" interventions. However, for a clinical trial of stem cell or gene therapy intervention, potential participants will be","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[1992,1745],[1992,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1872,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e08471bb3d6746759ce040dbfde4a612","type":"text","conversion_output":true,"text":"potentially eligible immediately after the final study visit of the stem cell or gene therapy clinical trial, so long as","text_display":" potentially eligible immediately after the final study visit of the stem cell or gene therapy clinical trial, so long as","confidence":0.9990234375,"confidence_rate":0.9999921837133647},{"cnt":[[120,1788],[1899,1788],[1899,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1780,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75d46cf7379041fdac7f69fd75dcd35e","type":"text","conversion_output":true,"text":"at least six months has passed since the participant received their final treatment in the stem cell or gene","text_display":" at least six months has passed since the participant received their final treatment in the stem cell or gene","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1867,1830],[1867,1876],[120,1876]],"region":{"top_left_x":120,"top_left_y":1830,"width":1747,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ef514ca3b6e449b8c208375600fdafd","type":"text","conversion_output":true,"text":"therapy intervention. 8. Potential participants already walking for exercise at a level comparable to that","text_display":" therapy intervention. 8. Potential participants already walking for exercise at a level comparable to that","confidence":1,"confidence_rate":1},{"cnt":[[120,1876],[1931,1876],[1931,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1875,"width":1812,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b0cb69198fc44cf971c6ab7cde032b5","type":"text","conversion_output":true,"text":"targeted in the exercise intervention and those receiving G-CSF, GM-CSF, or erythropoietin within the past","text_display":" targeted in the exercise intervention and those receiving G-CSF, GM-CSF, or erythropoietin within the past","confidence":1,"confidence_rate":1},{"cnt":[[120,1921],[1850,1921],[1850,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1920,"width":1730,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f4d98f5fe45f4468aac7251b1c850949","type":"text","conversion_output":true,"text":"year will be excluded because these interventions may influence study outcomes independently of the","text_display":" year will be excluded because these interventions may influence study outcomes independently of the","confidence":0.99951171875,"confidence_rate":0.9999953038523912},{"cnt":[[120,1964],[1923,1964],[1923,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1803,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9230633bebd641da9ebf109e9e021fe4","type":"text","conversion_output":true,"text":"interventions. 9. Pre-menopausal women will be excluded because cyclic estrogen changes can influence","text_display":" interventions. 9. Pre-menopausal women will be excluded because cyclic estrogen changes can influence","confidence":1,"confidence_rate":1},{"cnt":[[120,2007],[1979,2007],[1979,2054],[120,2054]],"region":{"top_left_x":120,"top_left_y":2006,"width":1859,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6521280c0534e3089877917d93e522e","type":"text","conversion_output":true,"text":"progenitor cell levels. 10. Potential participants with diabetes and documented proliferative retinopathy, those","text_display":" progenitor cell levels. 10. Potential participants with diabetes and documented proliferative retinopathy, those","confidence":0.9965834617614746,"confidence_rate":0.999970749248898},{"cnt":[[120,2052],[1983,2052],[1983,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2051,"width":1864,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08665cb5f9c149219793048cc184b707","type":"text","conversion_output":true,"text":"with history of myeloid malignancy, and those treated for late stage cancer during the previous three years will","text_display":" with history of myeloid malignancy, and those treated for late stage cancer during the previous three years will","confidence":1,"confidence_rate":1},{"cnt":[[120,2097],[1841,2097],[1841,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2096,"width":1722,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39e03a98da9641f1b0890c687de1a7b3","type":"text","conversion_output":true,"text":"be excluded because GM-CSF may exacerbate these conditions. 11. Potential participants who fail to","text_display":" be excluded because GM-CSF may exacerbate these conditions. 11. Potential participants who fail to","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1949,2140],[1949,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1829,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"41f94e10aae94d10b403bb69fe2144ee","type":"text","conversion_output":true,"text":"complete the study run-in requirements will be excluded because it may be difficult for them to adhere to the","text_display":" complete the study run-in requirements will be excluded because it may be difficult for them to adhere to the","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1989,2183],[1989,2228],[120,2228]],"region":{"top_left_x":120,"top_left_y":2182,"width":1870,"height":46},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a55a21ce1d404bddaeb4e742d5486f4d","type":"text","conversion_output":true,"text":"study requirements; 12 . Potential participants who are deemed poor candidates for the study may be excluded","text_display":" study requirements; 12 . Potential participants who are deemed poor candidates for the study may be excluded","confidence":0.6826171875,"confidence_rate":0.996713850356688},{"cnt":[[120,2226],[1927,2226],[1927,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2225,"width":1808,"height":49},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42a657aba9ca48beb72299bb38c8faef","type":"text","conversion_output":true,"text":"at the discretion of the principal investigator. For example, potential participants who are argumentative or","text_display":" at the discretion of the principal investigator. For example, potential participants who are argumentative or","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[1263,2271],[1263,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1144,"height":47},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"861f6852e41342fdbe7e903b759b7320","type":"text","conversion_output":true,"text":"disruptive during study visits may not be well suited to the program.","text_display":" disruptive during study visits may not be well suited to the program.","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1957,2359],[1957,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1838,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0867d40de0e34ce8b3aaf9261f4df217","type":"text","conversion_output":true,"text":"C5. Recruitment. We will identify and randomize 267 PAD participants over 49 -months, allowing for a \\(10 \\%\\)","text_display":"\n\nC5. Recruitment. We will identify and randomize 267 PAD participants over 49 -months, allowing for a \\(10 \\%\\)","confidence":0.961076439358294,"confidence_rate":0.9996518033389256},{"cnt":[[120,2402],[1927,2402],[1927,2447],[120,2447]],"region":{"top_left_x":120,"top_left_y":2401,"width":1808,"height":47},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7dc17a037414a218318f32f630e678e","type":"text","conversion_output":true,"text":"drop-out at 6 -month follow-up (see timeline in our budget justification). This projected \\(10 \\%\\) drop-out rate is","text_display":" drop-out at 6 -month follow-up (see timeline in our budget justification). This projected \\(10 \\%\\) drop-out rate is","confidence":0.7014627456665039,"confidence_rate":0.9970738145473821},{"cnt":[[120,2447],[1863,2447],[1863,2494],[120,2494]],"region":{"top_left_x":120,"top_left_y":2447,"width":1743,"height":48},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d8a65f45eb74774bdcc62bd1444e397","type":"text","conversion_output":true,"text":"greater than the six-month drop-out rate of \\(7.7 \\%\\) in our recently completed SILC randomized controlled","text_display":" greater than the six-month drop-out rate of \\(7.7 \\%\\) in our recently completed SILC randomized controlled","confidence":0.90869140625,"confidence_rate":0.9991219478281308},{"cnt":[[120,2488],[1964,2488],[1964,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":1844,"height":51},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2817e8c2d6414ccca3d3f5763e0fa691","type":"text","conversion_output":true,"text":"exercise clinical trial (44). Thus, our projected drop-out rate is reasonable. As in our previous clinical trials of","text_display":" exercise clinical trial (44). Thus, our projected drop-out rate is reasonable. As in our previous clinical trials of","confidence":0.9960966110229492,"confidence_rate":0.9999676779844947},{"cnt":[[120,2535],[1966,2535],[1966,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2535,"width":1846,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b2a368addd24aadbbac65f92ef11836","type":"text","conversion_output":true,"text":"patients with PAD, we will identify potential participants with the following methods: 1) Use of Northwestern's","text_display":" patients with PAD, we will identify potential participants with the following methods: 1) Use of Northwestern's","confidence":0.994140625,"confidence_rate":0.9999493408652088},{"cnt":[[1048,2582],[1079,2582],[1079,2628],[1048,2628]],"region":{"top_left_x":1048,"top_left_y":2582,"width":31,"height":46},"line":56,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce4400feb82c4f6ca8069c91c2964c5a","type":"page_info","conversion_output":false,"text":"9","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-10","page":10,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"90aebbcc95ea4f93bc46e339c95504c7","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,165],[1740,165]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e9a64553a4be474d99883ca1fed0d38c","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1949,206],[1949,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1829,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30737a8f36194869aabbdada6661bdba","type":"text","conversion_output":true,"text":"Enterprise Data Warehouse to identify consecutive patients with PAD or patients at high risk for having PAD","text_display":"\n\nEnterprise Data Warehouse to identify consecutive patients with PAD or patients at high risk for having PAD","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,249],[1936,249],[1936,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1816,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"600f23ca03a44d47bbb46cc79dee8b39","type":"text","conversion_output":true,"text":"from Northwestern Medicine, including the Regional Medical Group in the western suburbs. We will contact","text_display":" from Northwestern Medicine, including the Regional Medical Group in the western suburbs. We will contact","confidence":1,"confidence_rate":1},{"cnt":[[120,294],[1914,294],[1914,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1795,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83c97a660755469ab13603f6bad88744","type":"text","conversion_output":true,"text":"physicians via phone, email, page, or fax prior to contacting their patients. If physicians do not reply within","text_display":" physicians via phone, email, page, or fax prior to contacting their patients. If physicians do not reply within","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1910,339],[1910,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1790,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5bd0f01825349bea035e6a5bc2a7244","type":"text","conversion_output":true,"text":"three weeks, up to five letters will be sent directly to the patient three weeks apart; 2 ) television, radio and","text_display":" three weeks, up to five letters will be sent directly to the patient three weeks apart; 2 ) television, radio and","confidence":0.98779296875,"confidence_rate":0.9998984997879278},{"cnt":[[120,382],[1931,382],[1931,430],[120,430]],"region":{"top_left_x":120,"top_left_y":382,"width":1812,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38198a1d838045b598375c534b5d57bd","type":"text","conversion_output":true,"text":"newspaper advertising; 3) postcard mailings to men and women living in the wider Chicago area; 4) Mailed","text_display":" newspaper advertising; 3) postcard mailings to men and women living in the wider Chicago area; 4) Mailed","confidence":0.9931793075574539,"confidence_rate":0.999937212432876},{"cnt":[[120,425],[1987,425],[1987,475],[120,475]],"region":{"top_left_x":120,"top_left_y":425,"width":1868,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ea84b69c76d486e8acf2052bb14eeaf","type":"text","conversion_output":true,"text":"letters to participants in the Lifeline Screening program who were found to have PAD; 5) Study brochures and","text_display":" letters to participants in the Lifeline Screening program who were found to have PAD; 5) Study brochures and","confidence":1,"confidence_rate":1},{"cnt":[[120,468],[1970,468],[1970,518],[120,518]],"region":{"top_left_x":120,"top_left_y":468,"width":1851,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"627ba2c6cb8b4d52a5086ce95a4ab676","type":"text","conversion_output":true,"text":"information flyers. 6) Mailed letters to University of Chicago patients with known PAD. A research coordinator","text_display":" information flyers. 6) Mailed letters to University of Chicago patients with known PAD. A research coordinator","confidence":0.998046875,"confidence_rate":0.9999829998415843},{"cnt":[[120,516],[2002,516],[2002,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1883,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aee3df1275594fe09b9a423d3c79021f","type":"text","conversion_output":true,"text":"at the University of Chicago will provide a list of patients with known PAD and NU coordinators will send letters,","text_display":" at the University of Chicago will provide a list of patients with known PAD and NU coordinators will send letters,","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1987,559],[1987,606],[120,606]],"region":{"top_left_x":120,"top_left_y":558,"width":1868,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48b52924a5a044e4a9a8cbb22c61729f","type":"text","conversion_output":true,"text":"signed by a UofC physician, and make follow-up calls from UofC. 7) Mailed letters to Jesse Brown VA Medical","text_display":" signed by a UofC physician, and make follow-up calls from UofC. 7) Mailed letters to Jesse Brown VA Medical","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1901,602],[1901,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1782,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64ec593dc18b426a9498c295020b3a71","type":"text","conversion_output":true,"text":"Center patients with known PAD. A research coordinator with WOC status at JBVAMC will send letters to","text_display":" Center patients with known PAD. A research coordinator with WOC status at JBVAMC will send letters to","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1901,645],[1901,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1782,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7b86746b68641f5b01fcf33b36e60dc","type":"text","conversion_output":true,"text":"JBVAMC patients with PAD and make follow-up calls from JBVAMC. Participants recruited through these","text_display":" JBVAMC patients with PAD and make follow-up calls from JBVAMC. Participants recruited through these","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1955,690],[1955,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1836,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a212c72faf6544e7be5e156fa30e5b59","type":"text","conversion_output":true,"text":"methods will sign a VA consent document and will undergo some study testing on-site at the VA. Study tests","text_display":" methods will sign a VA consent document and will undergo some study testing on-site at the VA. Study tests","confidence":1,"confidence_rate":1},{"cnt":[[120,735],[1884,735],[1884,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1765,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0997fa6aa5a641929e16b662fd23a881","type":"text","conversion_output":true,"text":"include questionnaires and functional performance measures. We have successfully used each of these","text_display":" include questionnaires and functional performance measures. We have successfully used each of these","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1240,778],[1240,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1120,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec42e6ba70a1448a9a98158e2d96bfab","type":"text","conversion_output":true,"text":"methods in our prior or ongoing clinical trials of patients with PAD.","text_display":" methods in our prior or ongoing clinical trials of patients with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1972,821],[1972,868],[120,868]],"region":{"top_left_x":120,"top_left_y":820,"width":1853,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b710009f5c634c52a15889e54aefdba7","type":"text","conversion_output":true,"text":"Evidence of our experience successfully recruiting PAD participants for NHLBI-funded studies: In the","text_display":"\nEvidence of our experience successfully recruiting PAD participants for NHLBI-funded studies: In the","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[120,866],[2000,866],[2000,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1881,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6463d3c9e8634922bc24525442f17bd9","type":"text","conversion_output":true,"text":"past five years we have randomized \\(>463\\) PAD participants into NHLBI-funded clinical trials. In addition, since","text_display":" past five years we have randomized \\(>463\\) PAD participants into NHLBI-funded clinical trials. In addition, since","confidence":0.57275390625,"confidence_rate":0.9952882611859724},{"cnt":[[122,909],[1901,909],[1901,956],[122,956]],"region":{"top_left_x":122,"top_left_y":908,"width":1780,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e00c37657a84661ab58a99783f87354","type":"text","conversion_output":true,"text":"1998, we have enrolled more than 1,800 men and women with PAD into our NHLBI-funded studies (R01-","text_display":" 1998, we have enrolled more than 1,800 men and women with PAD into our NHLBI-funded studies (R01","confidence":0.97802734375,"confidence_rate":0.9997884257136294},{"cnt":[[120,954],[1955,954],[1955,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1836,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2089d02cc25d4de9926cef6c89bb8d23","type":"text","conversion_output":true,"text":"HL58099, R01-HL073351, R01-HL071223, R01-HL073912, R01-HL083064, and R01-HL089198). We have","text_display":"HL58099, R01-HL073351, R01-HL071223, R01-HL073912, R01-HL083064, and R01-HL089198). We have","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1904,997],[1904,1044],[120,1044]],"region":{"top_left_x":120,"top_left_y":996,"width":1784,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c56a0560938c494d9dafbb86bd9601cf","type":"text","conversion_output":true,"text":"accomplished this using methods described above and by partnering with other Chicago medical centers.","text_display":" accomplished this using methods described above and by partnering with other Chicago medical centers.","confidence":1,"confidence_rate":1},{"cnt":[[120,1085],[1989,1085],[1989,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1084,"width":1870,"height":49},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"099da202be07443f862ea06735cca6fd","type":"text","conversion_output":true,"text":"C6. Randomization. Participants will be randomized to one of four arms using a SAS computer program (see","text_display":"\n\nC6. Randomization. Participants will be randomized to one of four arms using a SAS computer program (see","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1987,1130],[1987,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1868,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3593c2b4269434fa2186ae583d771e3","type":"text","conversion_output":true,"text":"Table 5). Participants will be stratified by diabetes mellitus, since patients with diabetes have fewer progenitor","text_display":" Table 5). Participants will be stratified by diabetes mellitus, since patients with diabetes have fewer progenitor","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1946,1173],[1946,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1827,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a14bad2de1c0450cbaa56267d0efab2f","type":"text","conversion_output":true,"text":"cells than those without diabetes \\((49,50)\\). Based on our prior work, we anticipate that approximately \\(25 \\%\\) to","text_display":" cells than those without diabetes \\((49,50)\\). Based on our prior work, we anticipate that approximately \\(25 \\%\\) to","confidence":0.99951171875,"confidence_rate":0.9999958958025558},{"cnt":[[120,1216],[1880,1216],[1880,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1760,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a2741693d074c5387bdb018482a375d","type":"text","conversion_output":true,"text":"\\(30 \\%\\) of participants will have diabetes ( 44 ). Block randomization will be implemented to ensure balance","text_display":" \\(30 \\%\\) of participants will have diabetes ( 44 ). Block randomization will be implemented to ensure balance","confidence":0.9396743774414062,"confidence_rate":0.9994395996891767},{"cnt":[[120,1259],[1979,1259],[1979,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1258,"width":1859,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd583a21e71041ab8feb054854c30e61","type":"text","conversion_output":true,"text":"between the four groups throughout recruitment. Block sizes will be randomly selected from eight and twelve.","text_display":" between the four groups throughout recruitment. Block sizes will be randomly selected from eight and twelve.","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1869,1349],[1869,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1750,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3fdeae070ca74e4ea5a1bdf410018cda","type":"text","conversion_output":true,"text":"C7. Supervised treadmill exercise program. Our exercise training protocol is based on prior studies,","text_display":"\n\nC7. Supervised treadmill exercise program. Our exercise training protocol is based on prior studies,","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1987,1392],[1987,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1868,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b75af32232f441dc96b7586dbd172709","type":"text","conversion_output":true,"text":"including our SILC clinical trial of exercise in PAD, and is consistent with current clinical practice guidelines for","text_display":" including our SILC clinical trial of exercise in PAD, and is consistent with current clinical practice guidelines for","confidence":1,"confidence_rate":1},{"cnt":[[120,1435],[1966,1435],[1966,1482],[120,1482]],"region":{"top_left_x":120,"top_left_y":1435,"width":1846,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f18d33891d3646cbaf22d389c30a19ef","type":"text","conversion_output":true,"text":"PAD patients ( \\(35,44,65-67\\) ). Our exercise intervention will be delivered three times weekly. In the first week,","text_display":" PAD patients ( \\(35,44,65-67\\) ). Our exercise intervention will be delivered three times weekly. In the first week,","confidence":0.9819502830505371,"confidence_rate":0.9998482231845378},{"cnt":[[120,1480],[1880,1480],[1880,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1760,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"213f93428ca14823a2a672348102d17e","type":"text","conversion_output":true,"text":"participants will be asked to exercise 15 minutes per session (excluding rest periods). Walking exercise","text_display":" participants will be asked to exercise 15 minutes per session (excluding rest periods). Walking exercise","confidence":1,"confidence_rate":1},{"cnt":[[120,1525],[2000,1525],[2000,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":1881,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e132863915474d3ea5db4ca645fd3850","type":"text","conversion_output":true,"text":"duration will be increased by five minutes per session each week until 40 to 50 minutes of exercise per session","text_display":" duration will be increased by five minutes per session each week until 40 to 50 minutes of exercise per session","confidence":1,"confidence_rate":1},{"cnt":[[120,1568],[2002,1568],[2002,1616],[120,1616]],"region":{"top_left_x":120,"top_left_y":1568,"width":1883,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87a12b423b504bcdb5b74eb725f792c9","type":"text","conversion_output":true,"text":"is achieved (35). At this point, exercise intensity will be increased by alternately increasing treadmill speed and","text_display":" is achieved (35). At this point, exercise intensity will be increased by alternately increasing treadmill speed and","confidence":0.994145393371582,"confidence_rate":0.9999510694302681},{"cnt":[[120,1611],[1974,1611],[1974,1659],[120,1659]],"region":{"top_left_x":120,"top_left_y":1611,"width":1855,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a7280f102f548219f88aed16e714d47","type":"text","conversion_output":true,"text":"treadmill grade. Exercise intensity will be set to ensure that at each exercise session, participants experience","text_display":" treadmill grade. Exercise intensity will be set to ensure that at each exercise session, participants experience","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[120,1656],[1867,1656],[1867,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1656,"width":1747,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c75fa094c2f140fa917022a5e8d99dbc","type":"text","conversion_output":true,"text":"ischemic leg symptoms within eight to ten minutes after onset of exercise. Participants will be asked to","text_display":" ischemic leg symptoms within eight to ten minutes after onset of exercise. Participants will be asked to","confidence":1,"confidence_rate":1},{"cnt":[[120,1697],[1987,1697],[1987,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1868,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f73ce5e1eeb457d98fbbc7f376cac40","type":"text","conversion_output":true,"text":"continue walking until they achieve leg symptom severity of \" 4 or 5 \" on a visual analog pain scale ranging from","text_display":" continue walking until they achieve leg symptom severity of \" 4 or 5 \" on a visual analog pain scale ranging from","confidence":0.8779056072235107,"confidence_rate":0.9989504205491982},{"cnt":[[122,1745],[1944,1745],[1944,1790],[122,1790]],"region":{"top_left_x":122,"top_left_y":1744,"width":1823,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d67af91d0924136aa3a439d8593ce42","type":"text","conversion_output":true,"text":"1 to 5 . After achieving leg symptom severity of \" 4 or 5\" on the pain scale, participants will be allowed to rest","text_display":" 1 to 5 . After achieving leg symptom severity of \" 4 or 5\" on the pain scale, participants will be allowed to rest","confidence":0.8326558512635529,"confidence_rate":0.9985241959913242},{"cnt":[[120,1788],[1966,1788],[1966,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1846,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51e2f3fef116416491969db87176345a","type":"text","conversion_output":true,"text":"until they are able to resume walking again (i.e. when pain reduces to a 2 or 1 on the scale). This method will","text_display":" until they are able to resume walking again (i.e. when pain reduces to a 2 or 1 on the scale). This method will","confidence":0.9970724578015506,"confidence_rate":0.9999759688475067},{"cnt":[[120,1830],[1979,1830],[1979,1878],[120,1878]],"region":{"top_left_x":120,"top_left_y":1830,"width":1859,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7af8ece272644defb355ef295e373da1","type":"text","conversion_output":true,"text":"help ensure that calf muscle ischemia is induced, releasing nitric oxide and vascular endothelial growth factor,","text_display":" help ensure that calf muscle ischemia is induced, releasing nitric oxide and vascular endothelial growth factor,","confidence":1,"confidence_rate":1},{"cnt":[[120,1876],[1944,1876],[1944,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1875,"width":1825,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb3ebd6e868f44909df39786bbcbcb6d","type":"text","conversion_output":true,"text":"which in turn promote release of progenitor cells \\((68,69)\\). In the subset of participants without exertional leg","text_display":" which in turn promote release of progenitor cells \\((68,69)\\). In the subset of participants without exertional leg","confidence":0.94921875,"confidence_rate":0.9995657942851062},{"cnt":[[120,1921],[1979,1921],[1979,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1920,"width":1859,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b430d70e3bf422688e279efa870acb6","type":"text","conversion_output":true,"text":"symptoms (i.e. those with asymptomatic PAD), participants will be asked to exercise to achieve a Borg Rating","text_display":" symptoms (i.e. those with asymptomatic PAD), participants will be asked to exercise to achieve a Borg Rating","confidence":0.998046875,"confidence_rate":0.9999826989564276},{"cnt":[[120,1964],[1962,1964],[1962,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1842,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9644143e9975404ea7b698e67a65c8df","type":"text","conversion_output":true,"text":"of Perceived Exertion (RPE) score of \\(12-14(70-73)\\). To ensure that exercise intensity is sufficient to achieve","text_display":" of Perceived Exertion (RPE) score of \\(12-14(70-73)\\). To ensure that exercise intensity is sufficient to achieve","confidence":0.6197948455810547,"confidence_rate":0.995954250676879},{"cnt":[[120,2007],[1987,2007],[1987,2054],[120,2054]],"region":{"top_left_x":120,"top_left_y":2006,"width":1868,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b78391343394c5591496ffbad4b7fcf","type":"text","conversion_output":true,"text":"an anaerobic state during exercise, we will measure lactic acid levels every two to four weeks at the beginning","text_display":" an anaerobic state during exercise, we will measure lactic acid levels every two to four weeks at the beginning","confidence":1,"confidence_rate":1},{"cnt":[[120,2050],[1981,2048],[1981,2097],[120,2099]],"region":{"top_left_x":120,"top_left_y":2047,"width":1861,"height":53},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98368dfffe30464ba7f1a2baeff6bf64","type":"text","conversion_output":true,"text":"and end of exercise sessions. Participants whose lactic acid does not increase during exercise will have their","text_display":" and end of exercise sessions. Participants whose lactic acid does not increase during exercise will have their","confidence":1,"confidence_rate":1},{"cnt":[[120,2095],[1983,2095],[1983,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2094,"width":1864,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c5e98ff481b4053a7d8e1d163b7c883","type":"text","conversion_output":true,"text":"exercise intensity increased at the next session and will be even more closely monitored for exercise intensity.","text_display":" exercise intensity increased at the next session and will be even more closely monitored for exercise intensity.","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1949,2183],[1949,2230],[120,2230]],"region":{"top_left_x":120,"top_left_y":2182,"width":1829,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ff132e287ac4adcbc31117b46706f69","type":"text","conversion_output":true,"text":"C8. Attention Control Group. Our attention control group will control for the possibility that regular contact","text_display":"\n\nC8. Attention Control Group. Our attention control group will control for the possibility that regular contact","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1944,2226],[1944,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2225,"width":1825,"height":49},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c500b5496aaf4247aa521c7fcc1cb7d5","type":"text","conversion_output":true,"text":"with the study team may improve outcomes in participants randomized to supervised exercise. Participants","text_display":" with the study team may improve outcomes in participants randomized to supervised exercise. Participants","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[1944,2271],[1944,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1825,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b98bf9749e024326b3be65ea17b58db4","type":"text","conversion_output":true,"text":"randomized to the attention control group will attend weekly one-hour educational sessions at Northwestern","text_display":" randomized to the attention control group will attend weekly one-hour educational sessions at Northwestern","confidence":1,"confidence_rate":1},{"cnt":[[120,2314],[1970,2314],[1970,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2313,"width":1851,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfe0d807314043dfbc5b7889e6c70b85","type":"text","conversion_output":true,"text":"University for six months. These educational sessions are on topics of interest to the typical PAD patient and","text_display":" University for six months. These educational sessions are on topics of interest to the typical PAD patient and","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1987,2359],[1987,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1868,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5228f099b27b4bfabb88f1ad4412cee7","type":"text","conversion_output":true,"text":"are led by physicians and other health care workers. Topics include Medicare Part D, nutritional supplements,","text_display":" are led by physicians and other health care workers. Topics include Medicare Part D, nutritional supplements,","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1648,2402],[1648,2447],[120,2447]],"region":{"top_left_x":120,"top_left_y":2401,"width":1528,"height":47},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10a55fac530049cf8a6bef303e117316","type":"text","conversion_output":true,"text":"C-reactive protein, and hypertension. Sessions do not include information about exercise.","text_display":" C-reactive protein, and hypertension. Sessions do not include information about exercise.","confidence":1,"confidence_rate":1},{"cnt":[[120,2488],[1987,2488],[1987,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":1868,"height":51},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75eb4deb4ea74d24a99d683acea5266e","type":"text","conversion_output":true,"text":"C9. GM-CSF or placebo injections. GM-CSF or placebo will be administered subcutaneously by a registered","text_display":"\n\nC9. GM-CSF or placebo injections. GM-CSF or placebo will be administered subcutaneously by a registered","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[120,2533],[1957,2533],[1957,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2533,"width":1838,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae903adc88054ae59ba37ba6701f3dc9","type":"text","conversion_output":true,"text":"nurse or physician, three times weekly for two weeks, in a double-blinded fashion (i.e. both investigators and","text_display":" nurse or physician, three times weekly for two weeks, in a double-blinded fashion (i.e. both investigators and","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"338b021a914246a39d0c1d1c2c47b468","type":"page_info","conversion_output":false,"text":"10","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-11","page":11,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"40bf3e56f76a4a4cbf99f6123a8901b4","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,163],[1740,163]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c3704155f17b4bd38d33c75c0a0c0834","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1904,206],[1904,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1784,"height":46},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cd82bfe8729f4c199e281ad4fe5cbd69","type":"text","conversion_output":true,"text":"participants will be blinded to receipt of medication vs. placebo). GM-CSF will be used because the most","text_display":"\nparticipants will be blinded to receipt of medication vs. placebo). GM-CSF will be used because the most","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[1949,249],[1949,299],[120,299]],"region":{"top_left_x":120,"top_left_y":249,"width":1829,"height":50},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"12e96d5c3a7045ed88a21d82e9b001ca","type":"text","conversion_output":true,"text":"promising data regarding the association of colony stimulating factors with improved walking performance in","text_display":" promising data regarding the association of colony stimulating factors with improved walking performance in","confidence":1,"confidence_rate":1},{"cnt":[[120,294],[1970,294],[1970,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1851,"height":48},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b2e684833c0543c2b9e47f0ab54f4823","type":"text","conversion_output":true,"text":"PAD participants used GM-CSF (1). In addition, GM-CSF may be associated with a lower risk of thromboses","text_display":" PAD participants used GM-CSF (1). In addition, GM-CSF may be associated with a lower risk of thromboses","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1147,339],[1147,389],[120,389]],"region":{"top_left_x":120,"top_left_y":339,"width":1028,"height":50},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"89d9b69b040245efb0f1945687a49e8d","type":"text","conversion_output":true,"text":"than G-CSF (1). The dose of GM-CSF will be \\(250 ug / m ^{2} /\\) day","text_display":" than G-CSF (1). The dose of GM-CSF will be \\(250 ug / m ^{2} /\\) day","confidence":1,"confidence_rate":1},{"cnt":[[120,387],[1966,387],[1966,432],[120,432]],"region":{"top_left_x":120,"top_left_y":386,"width":1846,"height":46},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fe89784982ce48bd8cf7580cc0c2aaab","type":"text","conversion_output":true,"text":"subcutaneously three times weekly for two weeks (1). Higher doses of GM-CSF are not FDA approved. The","text_display":" subcutaneously three times weekly for two weeks (1). Higher doses of GM-CSF are not FDA approved. The","confidence":1,"confidence_rate":1},{"cnt":[[120,432],[1968,432],[1968,477],[120,477]],"region":{"top_left_x":120,"top_left_y":431,"width":1848,"height":46},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9cb805e248f64eb88134f4271d5aa461","type":"text","conversion_output":true,"text":"most promising preliminary study of GM-CSF to improve walking performance in PAD patients used doses of","text_display":" most promising preliminary study of GM-CSF to improve walking performance in PAD patients used doses of","confidence":1,"confidence_rate":1},{"cnt":[[120,475],[1921,475],[1921,522],[120,522]],"region":{"top_left_x":120,"top_left_y":474,"width":1801,"height":49},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"348125165ef84b6086d949875a2e0d5e","type":"text","conversion_output":true,"text":"3,6 and \\(10 ug / kg\\) administered three times weekly (1). Although there was no clear linear dose-response","text_display":" 3,6 and \\(10 ug / kg\\) administered three times weekly (1). Although there was no clear linear dose-response","confidence":0.6068404368732311,"confidence_rate":0.995628098791954},{"cnt":[[120,520],[1884,520],[1884,565],[120,565]],"region":{"top_left_x":120,"top_left_y":519,"width":1765,"height":47},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8788a00968fa4c5589b0bb49dafa5297","type":"text","conversion_output":true,"text":"association, the doses of \\(6 ug / kg\\) and \\(10 ug / kg\\) achieved the greatest number of circulating CD34+ cells,","text_display":" association, the doses of \\(6 ug / kg\\) and \\(10 ug / kg\\) achieved the greatest number of circulating CD34+ cells,","confidence":0.9917097059078515,"confidence_rate":0.9999328663689112},{"cnt":[[120,563],[1957,563],[1957,612],[120,612]],"region":{"top_left_x":120,"top_left_y":562,"width":1838,"height":51},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1dc14ee652654f92809f0121ce63078d","type":"text","conversion_output":true,"text":"compared to the lower dose (1). The proposed dose of \\(250 ug / m ^{2} /\\) day is expected to maximize benefit while","text_display":" compared to the lower dose (1). The proposed dose of \\(250 ug / m ^{2} /\\) day is expected to maximize benefit while","confidence":0.865234375,"confidence_rate":0.9988426314282652},{"cnt":[[120,610],[1974,610],[1974,655],[120,655]],"region":{"top_left_x":120,"top_left_y":610,"width":1855,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"095d8e313b60401bb99f21ea91d6c58e","type":"text","conversion_output":true,"text":"minimizing side effects. To monitor for adverse effects, we will measure white blood count (WBC) once each","text_display":" minimizing side effects. To monitor for adverse effects, we will measure white blood count (WBC) once each","confidence":1,"confidence_rate":1},{"cnt":[[116,653],[1906,653],[1906,698],[116,698]],"region":{"top_left_x":116,"top_left_y":653,"width":1790,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8737b698a78f46b5a83a2774ee527220","type":"text","conversion_output":true,"text":"week during the two weeks that the GM-CSF is administered. Additional WBCs might be measured at the","text_display":" week during the two weeks that the GM-CSF is administered. Additional WBCs might be measured at the","confidence":1,"confidence_rate":1},{"cnt":[[118,698],[1962,698],[1962,743],[118,743]],"region":{"top_left_x":118,"top_left_y":698,"width":1844,"height":46},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d17edecc13974695b24598376efaf292","type":"text","conversion_output":true,"text":"discretion of the Safety Monitor, during the time period that study medication is administered. The study drug","text_display":" discretion of the Safety Monitor, during the time period that study medication is administered. The study drug","confidence":1,"confidence_rate":1},{"cnt":[[116,743],[1938,743],[1938,786],[116,786]],"region":{"top_left_x":116,"top_left_y":743,"width":1822,"height":44},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93e753ce2d0a48659d2c794452f684a3","type":"text","conversion_output":true,"text":"will be discontinued if the participant experiences an arterial thrombotic event or is hospitalized for a reason","text_display":" will be discontinued if the participant experiences an arterial thrombotic event or is hospitalized for a reason","confidence":1,"confidence_rate":1},{"cnt":[[118,786],[1992,786],[1992,831],[118,831]],"region":{"top_left_x":118,"top_left_y":786,"width":1874,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc18483aaf72487db4c8f6594f184e1d","type":"text","conversion_output":true,"text":"that may be related to the study drug. If a participant is hospitalized for a reason that may be related to the use","text_display":" that may be related to the study drug. If a participant is hospitalized for a reason that may be related to the use","confidence":1,"confidence_rate":1},{"cnt":[[118,829],[1985,829],[1985,874],[118,874]],"region":{"top_left_x":118,"top_left_y":829,"width":1868,"height":46},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"959f7a1b112b410e85fcae8e32cf79db","type":"text","conversion_output":true,"text":"of the study drug, the decision to reduce the drug dosage or discontinue the drug will be made by study safety","text_display":" of the study drug, the decision to reduce the drug dosage or discontinue the drug will be made by study safety","confidence":1,"confidence_rate":1},{"cnt":[[118,872],[1934,872],[1934,920],[118,920]],"region":{"top_left_x":118,"top_left_y":872,"width":1816,"height":48},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"baf0f1ab50704fa7ad4286f682de0ef1","type":"text","conversion_output":true,"text":"officers Dr. Green or Dr. Lloyd-Jones on a case-by-case basis. In general, if a patient is suspected of acute","text_display":" officers Dr. Green or Dr. Lloyd-Jones on a case-by-case basis. In general, if a patient is suspected of acute","confidence":1,"confidence_rate":1},{"cnt":[[118,920],[1989,920],[1989,965],[118,965]],"region":{"top_left_x":118,"top_left_y":919,"width":1872,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5b962828cc9e4b198fddcdbd040fda79","type":"text","conversion_output":true,"text":"coronary syndrome or a new significant arrhythmia, their study drug injections will be withheld until appropriate","text_display":" coronary syndrome or a new significant arrhythmia, their study drug injections will be withheld until appropriate","confidence":1,"confidence_rate":1},{"cnt":[[118,962],[1897,962],[1897,1008],[118,1008]],"region":{"top_left_x":118,"top_left_y":962,"width":1780,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fd7fdeb2a2d4a16bdcb9780d3835f97","type":"text","conversion_output":true,"text":"medical work-up is completed. If the participant is determined NOT to have an acute coronary syndrome,","text_display":" medical work-up is completed. If the participant is determined NOT to have an acute coronary syndrome,","confidence":1,"confidence_rate":1},{"cnt":[[116,1005],[1833,1005],[1833,1051],[116,1051]],"region":{"top_left_x":116,"top_left_y":1005,"width":1717,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"15a91dfe2566453681aebad51f74e5e1","type":"text","conversion_output":true,"text":"active coronary disease, or a significant arrhythmia, the participant may resume full does of the study","text_display":" active coronary disease, or a significant arrhythmia, the participant may resume full does of the study","confidence":1,"confidence_rate":1},{"cnt":[[116,1051],[1996,1051],[1996,1096],[116,1096]],"region":{"top_left_x":116,"top_left_y":1050,"width":1880,"height":46},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"70c0862191e74f24a4e39979cfd7c360","type":"text","conversion_output":true,"text":"medication. However, if the participant is determined to have an acute coronary syndrome or active, significant","text_display":" medication. However, if the participant is determined to have an acute coronary syndrome or active, significant","confidence":1,"confidence_rate":1},{"cnt":[[118,1096],[1987,1096],[1987,1141],[118,1141]],"region":{"top_left_x":118,"top_left_y":1095,"width":1870,"height":46},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3a8d66ea59fe4924b0ee8a0d6a6efdba","type":"text","conversion_output":true,"text":"arrhythmia, then additional receipt of study drug, at full-dose or reduced does, will be made on a case-by-case","text_display":" arrhythmia, then additional receipt of study drug, at full-dose or reduced does, will be made on a case-by-case","confidence":1,"confidence_rate":1},{"cnt":[[118,1139],[1996,1139],[1996,1182],[118,1182]],"region":{"top_left_x":118,"top_left_y":1138,"width":1878,"height":44},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55b7ab2bbc1940f5a54aa40bd2a90766","type":"text","conversion_output":true,"text":"basis by the study safety officers. The study nurse will have Tylenol available in the event of acute muscle pain","text_display":" basis by the study safety officers. The study nurse will have Tylenol available in the event of acute muscle pain","confidence":1,"confidence_rate":1},{"cnt":[[118,1182],[1970,1182],[1970,1227],[118,1227]],"region":{"top_left_x":118,"top_left_y":1181,"width":1853,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"843ff20b0382416eb5e7931f092e69e6","type":"text","conversion_output":true,"text":"following the study injection. The Tylenol will be provided by NMH pharmacy and administered at a maximum","text_display":" following the study injection. The Tylenol will be provided by NMH pharmacy and administered at a maximum","confidence":1,"confidence_rate":1},{"cnt":[[116,1225],[410,1225],[410,1270],[116,1270]],"region":{"top_left_x":116,"top_left_y":1224,"width":295,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7c2d4a88a194ab89d3c5debcc490c82","type":"text","conversion_output":true,"text":"dose of 1000 mg .","text_display":" dose of 1000 mg .","confidence":1,"confidence_rate":1},{"cnt":[[120,1313],[1910,1313],[1910,1360],[120,1360]],"region":{"top_left_x":120,"top_left_y":1312,"width":1790,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6bec82eed83f49eab98ef6d88a4be85b","type":"text","conversion_output":true,"text":"Monitored Walking Program: Potentially eligible study participants will be telephoned by study staff and","text_display":"\n\nMonitored Walking Program: Potentially eligible study participants will be telephoned by study staff and","confidence":1,"confidence_rate":1},{"cnt":[[120,1358],[1901,1358],[1901,1403],[120,1403]],"region":{"top_left_x":120,"top_left_y":1357,"width":1782,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8aece589fbb4430f9510e09999d0fd2e","type":"text","conversion_output":true,"text":"invited to participate in this walking program. Interested participants will be asked to come to our walking","text_display":" invited to participate in this walking program. 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They will be shown how to use their device. They will be asked to use their device to","text_display":" walking exercise activity. They will be shown how to use their device. They will be asked to use their device to","confidence":1,"confidence_rate":1},{"cnt":[[120,1534],[2004,1534],[2004,1579],[120,1579]],"region":{"top_left_x":120,"top_left_y":1533,"width":1885,"height":47},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e384f608e4e44c2fa3be9b5495285d6e","type":"text","conversion_output":true,"text":"monitor their activity, including walking exercise activity. They will be shown how to transmit the data from their","text_display":" monitor their activity, including walking exercise activity. They will be shown how to transmit the data from their","confidence":1,"confidence_rate":1},{"cnt":[[120,1577],[1936,1577],[1936,1622],[120,1622]],"region":{"top_left_x":120,"top_left_y":1576,"width":1816,"height":47},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5162f7ba110e4f5987027b16ee1b8796","type":"text","conversion_output":true,"text":"accelerometer/pedometer back to the study coach. They will also be asked to record data on exercise time","text_display":" accelerometer/pedometer back to the study coach. They will also be asked to record data on exercise time","confidence":1,"confidence_rate":1},{"cnt":[[120,1622],[2000,1622],[2000,1667],[120,1667]],"region":{"top_left_x":120,"top_left_y":1622,"width":1881,"height":46},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c2cce1f73256457492f8b27dacf880b9","type":"text","conversion_output":true,"text":"and distance using a paper tracking form. They may also be asked to send a text message to the study coach","text_display":" and distance using a paper tracking form. They may also be asked to send a text message to the study coach","confidence":1,"confidence_rate":1},{"cnt":[[120,1665],[1916,1665],[1916,1710],[120,1710]],"region":{"top_left_x":120,"top_left_y":1665,"width":1797,"height":46},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"47ac393287ff4202bb956eb8eb91d624","type":"text","conversion_output":true,"text":"at the start and end of each walking exercise session, with details about their walking activity including the","text_display":" at the start and end of each walking exercise session, with details about their walking activity including the","confidence":1,"confidence_rate":1},{"cnt":[[120,1708],[1012,1708],[1012,1755],[120,1755]],"region":{"top_left_x":120,"top_left_y":1708,"width":892,"height":48},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e87805e9b49244e683924bc733911fb8","type":"text","conversion_output":true,"text":"duration and intensity of each walking exercise bout.","text_display":" duration and intensity of each walking exercise bout.","confidence":1,"confidence_rate":1},{"cnt":[[122,1796],[1936,1796],[1936,1841],[122,1841]],"region":{"top_left_x":122,"top_left_y":1796,"width":1814,"height":46},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8fcfd4c96254470380e31dbff1703836","type":"text","conversion_output":true,"text":"In this monitored walking program, participants will be randomized to walk for exercise at low intensity (with","text_display":"\n\nIn this monitored walking program, participants will be randomized to walk for exercise at low intensity (with","confidence":1,"confidence_rate":1},{"cnt":[[120,1839],[1803,1839],[1803,1886],[120,1886]],"region":{"top_left_x":120,"top_left_y":1839,"width":1683,"height":48},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"85f1c76ea42e40618342d5de1c092ff8","type":"text","conversion_output":true,"text":"minimal to no leg symptoms) or high intensity (with maximal leg symptoms during exercise activity).","text_display":" minimal to no leg symptoms) or high intensity (with maximal leg symptoms during exercise activity).","confidence":1,"confidence_rate":1},{"cnt":[[120,1884],[1837,1884],[1837,1929],[120,1929]],"region":{"top_left_x":120,"top_left_y":1884,"width":1717,"height":46},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31c9100298824f378b3b1b3d53579fd7","type":"text","conversion_output":true,"text":"Participants will be asked to walk around the track at the exercise facility or up and down a hallway at","text_display":" Participants will be asked to walk around the track at the exercise facility or up and down a hallway at","confidence":1,"confidence_rate":1},{"cnt":[[120,1929],[1858,1929],[1858,1974],[120,1974]],"region":{"top_left_x":120,"top_left_y":1929,"width":1739,"height":46},"line":40,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"386076d4c3e342fda65e491d061a6abe","type":"text","conversion_output":true,"text":"Northwestern Memorial Hospital in order to learn the pace to walk according to their assignment to low","text_display":" Northwestern Memorial Hospital in order to learn the pace to walk according to their assignment to low","confidence":1,"confidence_rate":1},{"cnt":[[120,1972],[2000,1972],[2000,2017],[120,2017]],"region":{"top_left_x":120,"top_left_y":1972,"width":1881,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"704376376a0749ccb15957be30cfbb38","type":"text","conversion_output":true,"text":"intensity or high intensity exercise. Participants will then be helped to set targets (i.e. goals) for walking activity","text_display":" intensity or high intensity exercise. Participants will then be helped to set targets (i.e. goals) for walking activity","confidence":1,"confidence_rate":1},{"cnt":[[120,2015],[1929,2015],[1929,2060],[120,2060]],"region":{"top_left_x":120,"top_left_y":2015,"width":1810,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9f43333755da404b9de253b82ab142d6","type":"text","conversion_output":true,"text":"during the next week. They may be asked to return to the exercise center for additional coaching, for up to","text_display":" during the next week. They may be asked to return to the exercise center for additional coaching, for up to","confidence":1,"confidence_rate":1},{"cnt":[[120,2058],[535,2058],[535,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2058,"width":415,"height":42},"line":43,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a4c022f1f7fd4286b2f4da7cac94fd53","type":"text","conversion_output":true,"text":"four additional sessions.","text_display":" four additional sessions.","confidence":1,"confidence_rate":1},{"cnt":[[122,2148],[1914,2148],[1914,2194],[122,2194]],"region":{"top_left_x":122,"top_left_y":2148,"width":1793,"height":46},"line":44,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7a871d8fbb494759a53b6b80a9cf0e1c","type":"text","conversion_output":true,"text":"Participants will be provided with walking exercise \"tracking\" forms and asked to write down their goals for","text_display":"\n\nParticipants will be provided with walking exercise \"tracking\" forms and asked to write down their goals for","confidence":1,"confidence_rate":1},{"cnt":[[120,2191],[1953,2191],[1953,2237],[120,2237]],"region":{"top_left_x":120,"top_left_y":2191,"width":1833,"height":46},"line":45,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"22508e301bd64773a526e2c1fa5419dd","type":"text","conversion_output":true,"text":"home-based walking activity each day for the next two weeks and record where and when they will exercise.","text_display":" home-based walking activity each day for the next two weeks and record where and when they will exercise.","confidence":1,"confidence_rate":1},{"cnt":[[120,2234],[1998,2234],[1998,2279],[120,2279]],"region":{"top_left_x":120,"top_left_y":2234,"width":1879,"height":46},"line":46,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ac36a4824bd5431a9ecebadfa6def6a6","type":"text","conversion_output":true,"text":"They will be provided with \"tracking' sheets on which to record their walking activity for each week that they are","text_display":" They will be provided with \"tracking' sheets on which to record their walking activity for each week that they are","confidence":1,"confidence_rate":1},{"cnt":[[120,2277],[1979,2277],[1979,2325],[120,2325]],"region":{"top_left_x":120,"top_left_y":2277,"width":1859,"height":48},"line":47,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"52cd241b3ecb4a86aa1f3959c680a457","type":"text","conversion_output":true,"text":"in the walking exercise program. After this initial on-site visit, study participants will be telephoned weekly for","text_display":" in the walking exercise program. After this initial on-site visit, study participants will be telephoned weekly for","confidence":1,"confidence_rate":1},{"cnt":[[120,2322],[1901,2322],[1901,2368],[120,2368]],"region":{"top_left_x":120,"top_left_y":2322,"width":1782,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d806adb5d9d142ef8b85bedf3e1bde44","type":"text","conversion_output":true,"text":"up to 14 weeks by a study coach who will review their walking exercise activity and provide feedback and","text_display":" up to 14 weeks by a study coach who will review their walking exercise activity and provide feedback and","confidence":1,"confidence_rate":1},{"cnt":[[120,2368],[1869,2368],[1869,2413],[120,2413]],"region":{"top_left_x":120,"top_left_y":2367,"width":1750,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c865bd0c9d984b87a69a7774f1ad5002","type":"text","conversion_output":true,"text":"encouragement. Participants may be visited at home or at their own exercise facility to monitor walking","text_display":" encouragement. Participants may be visited at home or at their own exercise facility to monitor walking","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[120,2411],[1974,2411],[1974,2456],[120,2456]],"region":{"top_left_x":120,"top_left_y":2410,"width":1855,"height":46},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5c845f3acbab414a86f8e2c098ecd4b1","type":"text","conversion_output":true,"text":"intensity. Each telephone call will last approximately 15 minutes. Participants will be asked to complete some","text_display":" intensity. Each telephone call will last approximately 15 minutes. Participants will be asked to complete some","confidence":1,"confidence_rate":1},{"cnt":[[120,2454],[1919,2454],[1919,2501],[120,2501]],"region":{"top_left_x":120,"top_left_y":2453,"width":1799,"height":48},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a62abd531ac84ca5ab4842a9c253a347","type":"text","conversion_output":true,"text":"study questionnaires before and after their participation in this program. They will be asked to return to the","text_display":" study questionnaires before and after their participation in this program. They will be asked to return to the","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b68e5e5c6994489a2c3d65a17b05d32","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-12","page":12,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bcb1d782659a4d2bb77f4403e2ed0817","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,163],[1740,163]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a89265e6c75248d5a0728a0f213aa0a7","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1921,206],[1921,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1801,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b46713fd1bd346f1ba9d5555d622c727","type":"text","conversion_output":true,"text":"medical center for final follow-up when they have completed the program. They will return their monitoring","text_display":"\nmedical center for final follow-up when they have completed the program. They will return their monitoring","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[552,249],[552,294],[120,294]],"region":{"top_left_x":120,"top_left_y":249,"width":433,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"198133492dd44da4852437ddc1c856ee","type":"text","conversion_output":true,"text":"devices at their final visit.","text_display":" devices at their final visit.","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1858,339],[1858,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1739,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4792f67d76144b728616f8853988354e","type":"text","conversion_output":true,"text":"Computerized Tablet or Computer Camera Study Visit: Potentially eligible study participants will be","text_display":"\n\nComputerized Tablet or Computer Camera Study Visit: Potentially eligible study participants will be","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[1931,382],[1931,432],[120,432]],"region":{"top_left_x":120,"top_left_y":382,"width":1812,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b60ba9b22ba4830ab4f9e6f63e66f6b","type":"text","conversion_output":true,"text":"telephoned by study staff and informed of the option of returning for a visit where they will be taught how to","text_display":" telephoned by study staff and informed of the option of returning for a visit where they will be taught how to","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1949,425],[1949,475],[120,475]],"region":{"top_left_x":120,"top_left_y":425,"width":1829,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f64ad1f4e5e2428fb83f94dd56f3cd2b","type":"text","conversion_output":true,"text":"operate a tablet or camera. Specifically, they will be taught how to link to video chat on the tablet or camera.","text_display":" operate a tablet or camera. Specifically, they will be taught how to link to video chat on the tablet or camera.","confidence":1,"confidence_rate":1},{"cnt":[[120,468],[1916,468],[1916,518],[120,518]],"region":{"top_left_x":120,"top_left_y":468,"width":1797,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af56269264f2466ba679dc2ff1063b51","type":"text","conversion_output":true,"text":"They may be asked at a later date to participate in up to three video chat sessions, in which they use their","text_display":" They may be asked at a later date to participate in up to three video chat sessions, in which they use their","confidence":1,"confidence_rate":1},{"cnt":[[120,511],[1987,511],[1987,561],[120,561]],"region":{"top_left_x":120,"top_left_y":511,"width":1868,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b1e04980d134d0f869db5dfebf54e74","type":"text","conversion_output":true,"text":"tablet or computer camera at home to connect with a group leader and other study participants with peripheral","text_display":" tablet or computer camera at home to connect with a group leader and other study participants with peripheral","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1897,559],[1897,606],[120,606]],"region":{"top_left_x":120,"top_left_y":558,"width":1778,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc7ef71977d94432a34b45973dea3d80","type":"text","conversion_output":true,"text":"artery disease. The video chat sessions will last one hour or less. Participants will be asked to return the","text_display":" artery disease. The video chat sessions will last one hour or less. Participants will be asked to return the","confidence":0.99853515625,"confidence_rate":0.9999870273612914},{"cnt":[[120,602],[1188,602],[1188,651],[120,651]],"region":{"top_left_x":120,"top_left_y":601,"width":1069,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"651deefd3d734e479e069cac9451a908","type":"text","conversion_output":true,"text":"tablets or cameras to investigators at the end of the pilot study.","text_display":" tablets or cameras to investigators at the end of the pilot study.","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1985,690],[1985,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1866,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2ae39d6034794e619e93578872f4903b","type":"text","conversion_output":true,"text":"MRI to measure lower extremity perfusion: To measure lower extremity blood flow or perfusion, we will use","text_display":"\n\nMRI to measure lower extremity perfusion: To measure lower extremity blood flow or perfusion, we will use","confidence":1,"confidence_rate":1},{"cnt":[[120,730],[1996,730],[1996,780],[120,780]],"region":{"top_left_x":120,"top_left_y":730,"width":1876,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31a0580dfc4d438fbc330c1ab32ecfef","type":"text","conversion_output":true,"text":"techniques in a subset of up to 50 participants who provide informed consent to this optional study element. In","text_display":" techniques in a subset of up to 50 participants who provide informed consent to this optional study element. In","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1940,778],[1940,827],[120,827]],"region":{"top_left_x":120,"top_left_y":777,"width":1821,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e166dec4bd714f879a542d975b9c1b94","type":"text","conversion_output":true,"text":"the MRI machine, we will ask participants to push against a plastic board with their feet (i.e. a plantarflexion","text_display":" the MRI machine, we will ask participants to push against a plastic board with their feet (i.e. a plantarflexion","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1996,821],[1996,870],[120,870]],"region":{"top_left_x":120,"top_left_y":820,"width":1876,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1043fc3a54424d46bf2ef0c77586bee4","type":"text","conversion_output":true,"text":"motion) repeatedly at a rate of one push per second. A metronome will be used to monitor the rate of pushing.","text_display":" motion) repeatedly at a rate of one push per second. A metronome will be used to monitor the rate of pushing.","confidence":1,"confidence_rate":1},{"cnt":[[120,864],[1940,864],[1940,913],[120,913]],"region":{"top_left_x":120,"top_left_y":863,"width":1821,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b3a1bfad03c54ee698f5d63bf535dce7","type":"text","conversion_output":true,"text":"Participants will be asked to push for as long as they are able. When they are too tired to continue, they will","text_display":" Participants will be asked to push for as long as they are able. When they are too tired to continue, they will","confidence":1,"confidence_rate":1},{"cnt":[[120,907],[1938,907],[1938,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1818,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aa70c8cadba249c9b370d75b34398dd6","type":"text","conversion_output":true,"text":"rest and perfusion to the calf muscle will be measured using MRI. This test will be conducted on a Siemens","text_display":" rest and perfusion to the calf muscle will be measured using MRI. This test will be conducted on a Siemens","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,952],[1987,950],[1987,1001],[120,1003]],"region":{"top_left_x":120,"top_left_y":949,"width":1868,"height":55},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7bf0a008b29341feb22d94893be5402e","type":"text","conversion_output":true,"text":"Tim Trio 3 Tessalon MR or a Siemens Skyra 3 Tessalon scanner at the Center for Translational Imaging (CTI)","text_display":" Tim Trio 3 Tessalon MR or a Siemens Skyra 3 Tessalon scanner at the Center for Translational Imaging (CTI)","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1992,997],[1992,1044],[120,1044]],"region":{"top_left_x":120,"top_left_y":996,"width":1872,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17e2270686504f3c94c175544168a4ba","type":"text","conversion_output":true,"text":"in the Olson Pavilion at Northwestern. If the designated Tim Trio or Skyra 3.0 Tessalon scanner is unavailable,","text_display":" in the Olson Pavilion at Northwestern. If the designated Tim Trio or Skyra 3.0 Tessalon scanner is unavailable,","confidence":0.998046875,"confidence_rate":0.9999831463934391},{"cnt":[[116,1040],[1983,1040],[1983,1089],[116,1089]],"region":{"top_left_x":116,"top_left_y":1039,"width":1868,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a542be7348d24104aa4df809a58a8954","type":"text","conversion_output":true,"text":"we will use a different 3.0 Tessalon scanner at Northwestern Memorial Hospital or the center for CTI. We may","text_display":" we will use a different 3.0 Tessalon scanner at Northwestern Memorial Hospital or the center for CTI. We may","confidence":0.9970703125,"confidence_rate":0.9999740358465011},{"cnt":[[116,1085],[1897,1085],[1897,1132],[116,1132]],"region":{"top_left_x":116,"top_left_y":1084,"width":1782,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"083c5abddca14e919bd9aed6ca9be638","type":"text","conversion_output":true,"text":"perform up to 3 perfusion MRI scans on individual participants, in order to conduct a test re-test reliability","text_display":" perform up to 3 perfusion MRI scans on individual participants, in order to conduct a test re-test reliability","confidence":1,"confidence_rate":1},{"cnt":[[116,1130],[1102,1130],[1102,1175],[116,1175]],"region":{"top_left_x":116,"top_left_y":1130,"width":987,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5dd3719249814821828ce3daaa4c9caf","type":"text","conversion_output":true,"text":"assessment. We will not use any contrast for this method.","text_display":" assessment. We will not use any contrast for this method.","confidence":0.98583984375,"confidence_rate":0.9997700043910049},{"cnt":[[116,1255],[563,1255],[563,1304],[116,1304]],"region":{"top_left_x":116,"top_left_y":1254,"width":447,"height":51},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"466cd8848f4a4b9491967d04cc1ad148","type":"section_header","conversion_output":false,"children_ids":["446ade8ea8814b6d86943531766ded77"],"text":"","text_display":""},{"cnt":[[120,1261],[561,1261],[561,1300],[120,1300]],"region":{"top_left_x":120,"top_left_y":1261,"width":441,"height":39},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"446ade8ea8814b6d86943531766ded77","type":"text","conversion_output":true,"parent_id":"466cd8848f4a4b9491967d04cc1ad148","text":"OUTCOME MEASURES.","text_display":"\n\n\\section*{OUTCOME MEASURES.}","confidence":0.998046875,"confidence_rate":0.9999111387285874},{"cnt":[[120,1302],[1934,1302],[1934,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1814,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7781533bf654a4ca628787d04468f3f","type":"text","conversion_output":true,"text":"C10. Justification for measuring primary outcomes at \\(1 2\\)-week follow-up. We recognize that the time","text_display":"\n\nC10. Justification for measuring primary outcomes at \\(1 2\\)-week follow-up. We recognize that the time","confidence":0.8326605409383774,"confidence_rate":0.998336573813562},{"cnt":[[120,1349],[1989,1349],[1989,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1870,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"878ecf6be56d4ac4973096559845dc04","type":"text","conversion_output":true,"text":"point at which study outcomes are maximally improved following GM-CSF therapy is unknown. The half life of","text_display":" point at which study outcomes are maximally improved following GM-CSF therapy is unknown. The half life of","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,1392],[1957,1392],[1957,1439],[120,1439]],"region":{"top_left_x":120,"top_left_y":1392,"width":1838,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f40a28750e3942998afbe72310b55210","type":"text","conversion_output":true,"text":"GM-CSF is 162 hours (75). Peak levels of circulating CD34+ cells are observed 5-6 days after onset of GM-","text_display":" GM-CSF is 162 hours (75). Peak levels of circulating CD34+ cells are observed 5-6 days after onset of GM","confidence":0.99560546875,"confidence_rate":0.9999610254003707},{"cnt":[[120,1435],[1985,1435],[1985,1485],[120,1485]],"region":{"top_left_x":120,"top_left_y":1435,"width":1866,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"366c304146314c928322c24d686a4e2d","type":"text","conversion_output":true,"text":"CSF therapy and subsequently decline even with continued GM-CSF injections \\((1,74,75)\\). However, available","text_display":"CSF therapy and subsequently decline even with continued GM-CSF injections \\((1,74,75)\\). However, available","confidence":0.682283878326416,"confidence_rate":0.9966224472158661},{"cnt":[[120,1480],[1989,1480],[1989,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1870,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae6f0dca82894c8ab313500246c79d96","type":"text","conversion_output":true,"text":"evidence supports measurement of our primary outcomes at 12 -week follow-up. First, a previous uncontrolled","text_display":" evidence supports measurement of our primary outcomes at 12 -week follow-up. First, a previous uncontrolled","confidence":0.9482421875,"confidence_rate":0.9995379733992805},{"cnt":[[120,1523],[1949,1523],[1949,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1523,"width":1829,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c32ef4828ee448f4bc9221c4a3c320f4","type":"text","conversion_output":true,"text":"clinical trial of 17 patients with PAD and critical limb ischemia demonstrated measurable improvement in toe","text_display":" clinical trial of 17 patients with PAD and critical limb ischemia demonstrated measurable improvement in toe","confidence":1,"confidence_rate":1},{"cnt":[[120,1568],[1938,1568],[1938,1618],[120,1618]],"region":{"top_left_x":120,"top_left_y":1568,"width":1818,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"747c6e9c02654d06ac4282e15fa01ffa","type":"text","conversion_output":true,"text":"brachial pressure index, TcPO2, and pain free walking distance four-weeks after CD34+ cells were injected","text_display":" brachial pressure index, TcPO2, and pain free walking distance four-weeks after CD34+ cells were injected","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[1888,1611],[1888,1661],[120,1661]],"region":{"top_left_x":120,"top_left_y":1611,"width":1769,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9180cf55354043fcab008c99719c4f5a","type":"text","conversion_output":true,"text":"into calf muscle of participants (76). These improvements persisted or even further improved at 24 -week","text_display":" into calf muscle of participants (76). These improvements persisted or even further improved at 24 -week","confidence":0.7193554192781448,"confidence_rate":0.9970632517871176},{"cnt":[[120,1654],[2004,1654],[2004,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1654,"width":1885,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cc538c33c684b1fbbbd6aa056fa022e","type":"text","conversion_output":true,"text":"follow-up (76). In a separate study, 22 patients with bilateral PAD were randomized to receive calf injections of","text_display":" follow-up (76). In a separate study, 22 patients with bilateral PAD were randomized to receive calf injections of","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[120,1697],[1893,1697],[1893,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1773,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c008ae36ad645b1a7d85a89b580936c","type":"text","conversion_output":true,"text":"autologous bone-marrow derived mononuclear cells vs. peripheral blood derived mononuclear cells (77).","text_display":" autologous bone-marrow derived mononuclear cells vs. peripheral blood derived mononuclear cells (77).","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,1745],[1962,1745],[1962,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1842,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5c7a6e38bac4e67b31c081ff708b398","type":"text","conversion_output":true,"text":"Four-weeks after the injections, measurable improvements in transcutaneous oxygen pressure and rest-pain","text_display":" Four-weeks after the injections, measurable improvements in transcutaneous oxygen pressure and rest-pain","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1861,1788],[1861,1835],[120,1835]],"region":{"top_left_x":120,"top_left_y":1787,"width":1741,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b87e5d5b63c7466dbe5db7a4d222a0fa","type":"text","conversion_output":true,"text":"were observed in the leg receiving bone-marrow derived cells compared to the leg receiving peripheral","text_display":" were observed in the leg receiving bone-marrow derived cells compared to the leg receiving peripheral","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1910,1830],[1910,1880],[120,1880]],"region":{"top_left_x":120,"top_left_y":1830,"width":1790,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"693a177ac5794e9bbfe6e3c4bfb448ed","type":"text","conversion_output":true,"text":"mononuclear cells (77). These improvements were sustained at 24 -week follow-up. Third, in the study by","text_display":" mononuclear cells (77). These improvements were sustained at 24 -week follow-up. Third, in the study by","confidence":0.9011883735656738,"confidence_rate":0.999063133083958},{"cnt":[[120,1873],[1871,1873],[1871,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1873,"width":1752,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e370514cc3f349e99dbe577798c37c8b","type":"text","conversion_output":true,"text":"Subramaniyam and colleagues, two-weeks of GM-CSF therapy was associated with improved treadmill","text_display":" Subramaniyam and colleagues, two-weeks of GM-CSF therapy was associated with improved treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,1919],[1944,1919],[1944,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1825,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"22651c01a20f497f920073ede766e5ab","type":"text","conversion_output":true,"text":"walking performance and brachial artery FMD at 12 -week follow-up (1). Similarly, in studies of patients with","text_display":" walking performance and brachial artery FMD at 12 -week follow-up (1). Similarly, in studies of patients with","confidence":0.5153732299804688,"confidence_rate":0.9943505150897852},{"cnt":[[120,1964],[1957,1964],[1957,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1838,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b18c792369374f73b6682d3d183bc11d","type":"text","conversion_output":true,"text":"coronary artery disease, improvements in cardiac ejection fractions or regional wall motion abnormalities are","text_display":" coronary artery disease, improvements in cardiac ejection fractions or regional wall motion abnormalities are","confidence":1,"confidence_rate":1},{"cnt":[[120,2007],[1970,2007],[1970,2056],[120,2056]],"region":{"top_left_x":120,"top_left_y":2006,"width":1851,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49efba437e1b45659b57442b3a643744","type":"text","conversion_output":true,"text":"typically first observed four to 12 weeks after \\(\\leq\\) two weeks of GM-CSF therapy (78-80). These improvements","text_display":" typically first observed four to 12 weeks after \\(\\leq\\) two weeks of GM-CSF therapy (78-80). These improvements","confidence":0.955810914747417,"confidence_rate":0.9996104623255907},{"cnt":[[120,2052],[1987,2052],[1987,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2051,"width":1868,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f691efabb6e4ddbb279edc97a97c289","type":"text","conversion_output":true,"text":"are maintained or even increase during follow-up periods of up to one year (78-80). In summary, although the","text_display":" are maintained or even increase during follow-up periods of up to one year (78-80). In summary, although the","confidence":1,"confidence_rate":1},{"cnt":[[120,2093],[1992,2093],[1992,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2092,"width":1872,"height":50},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bc951128dfe42ebb21fd17333787935","type":"text","conversion_output":true,"text":"optimal time point for measuring improved outcomes in response to GM-CSF is not established, available data","text_display":" optimal time point for measuring improved outcomes in response to GM-CSF is not established, available data","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1919,2140],[1919,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1799,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d6a70f0271541bd9978f585dbf4595d","type":"text","conversion_output":true,"text":"suggest that 12 weeks after therapy onset is a reasonable time point for measuring our primary outcomes.","text_display":" suggest that 12 weeks after therapy onset is a reasonable time point for measuring our primary outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1996,2183],[1996,2230],[120,2230]],"region":{"top_left_x":120,"top_left_y":2182,"width":1876,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f435ffc515dc4b58a4f2b528fdca2877","type":"text","conversion_output":true,"text":"Similarly, significant improvements in treadmill walking performance are observed 12 -weeks after initiation of a","text_display":" Similarly, significant improvements in treadmill walking performance are observed 12 -weeks after initiation of a","confidence":0.99609375,"confidence_rate":0.9999676542477538},{"cnt":[[120,2226],[1897,2226],[1897,2275],[120,2275]],"region":{"top_left_x":120,"top_left_y":2225,"width":1778,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2fcbfebd65349cd8bffc98a1508b236","type":"text","conversion_output":true,"text":"supervised treadmill exercise intervention (35,65-67). Our exploratory aim will assess the time course of","text_display":" supervised treadmill exercise intervention (35,65-67). Our exploratory aim will assess the time course of","confidence":0.8244144916534424,"confidence_rate":0.9982462500588952},{"cnt":[[120,2269],[1459,2269],[1459,2318],[120,2318]],"region":{"top_left_x":120,"top_left_y":2268,"width":1339,"height":51},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5eed996743c43a58e4a0055742521ca","type":"text","conversion_output":true,"text":"improved outcomes in response to GM-CSF therapy with and without exercise.","text_display":" improved outcomes in response to GM-CSF therapy with and without exercise.","confidence":1,"confidence_rate":1},{"cnt":[[120,2357],[1931,2357],[1931,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2356,"width":1812,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfb3daac10f14ebd8b6d128411ee74e3","type":"text","conversion_output":true,"text":"C11. Justification for measuring CD34+ cells as the primary progenitor cell outcome. We recognize","text_display":"\n\nC11. Justification for measuring CD34+ cells as the primary progenitor cell outcome. We recognize","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1919,2402],[1919,2451],[120,2451]],"region":{"top_left_x":120,"top_left_y":2401,"width":1799,"height":51},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0626262c005c415e954ec04f7c107a48","type":"text","conversion_output":true,"text":"that no single cell-surface marker is completely specific for endothelial progenitor cells (31). However, the","text_display":" that no single cell-surface marker is completely specific for endothelial progenitor cells (31). However, the","confidence":0.9970724582672119,"confidence_rate":0.9999742824766222},{"cnt":[[120,2445],[1983,2445],[1983,2494],[120,2494]],"region":{"top_left_x":120,"top_left_y":2444,"width":1864,"height":51},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b073bd0c9d0d460f99b7b101eb6b1b83","type":"text","conversion_output":true,"text":"CD34+ marker clearly identifies a population of functional progenitor cells that are released into the circulation","text_display":" CD34+ marker clearly identifies a population of functional progenitor cells that are released into the circulation","confidence":0.9990234375,"confidence_rate":0.9999917896164967},{"cnt":[[120,2488],[1807,2488],[1807,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":1687,"height":51},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7ef22472a274b608244bd7add1371c5","type":"text","conversion_output":true,"text":"in response to tissue ischemia, have the potential to differentiate into endothelial cells, and promote","text_display":" in response to tissue ischemia, have the potential to differentiate into endothelial cells, and promote","confidence":1,"confidence_rate":1},{"cnt":[[120,2533],[1861,2533],[1861,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2533,"width":1741,"height":48},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d447b1d9f3746dda5693abc8d546bf1","type":"text","conversion_output":true,"text":"angiogenesis ( \\(22,31,32,76\\) ). Based on these prior data, CD34+ cells will be our primary progenitor cell","text_display":" angiogenesis ( \\(22,31,32,76\\) ). Based on these prior data, CD34+ cells will be our primary progenitor cell","confidence":0.3943450783433037,"confidence_rate":0.9917261245629863},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b0d433f32fd4a239a45b37d6c531400","type":"page_info","conversion_output":false,"text":"12","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-13","page":13,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7adba8b9118a4dae8c90e526306c729c","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,163],[1740,163]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dbd4f1c3a903472b9a39c3f113338748","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1912,206],[1912,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1793,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e76f894f27a144688eb745b4d6862096","type":"text","conversion_output":true,"text":"outcome measurement. Please see sections A3 and A4 for further discussion of this issue. In exploratory","text_display":"\noutcome measurement. Please see sections A3 and A4 for further discussion of this issue. In exploratory","confidence":0.9990234375,"confidence_rate":0.9999909533775151},{"cnt":[[120,249],[1880,249],[1880,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1760,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f248d06590445f8818104ca805a29c9","type":"text","conversion_output":true,"text":"analyses, we will also measure CD133+ cells, KDR+ cells, ALDH bright cells, combinations of these cell","text_display":" analyses, we will also measure CD133+ cells, KDR+ cells, ALDH bright cells, combinations of these cell","confidence":1,"confidence_rate":1},{"cnt":[[120,296],[1949,296],[1949,342],[120,342]],"region":{"top_left_x":120,"top_left_y":296,"width":1829,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f521d4b54e0c4a9db1a62afe4d6fe98c","type":"text","conversion_output":true,"text":"markers, and progenitor cell colony forming units. It is important to point out that, compared to CD34+ cells,","text_display":" markers, and progenitor cell colony forming units. It is important to point out that, compared to CD34+ cells,","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1901,339],[1901,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1782,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3dae396999c43449771c0113a1df794","type":"text","conversion_output":true,"text":"these exploratory progenitor cell measures have not been as consistently linked to favorable outcomes in","text_display":" these exploratory progenitor cell measures have not been as consistently linked to favorable outcomes in","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[120,382],[1992,382],[1992,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1872,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"341a2540a7f844c29de7bc6f6ac08254","type":"text","conversion_output":true,"text":"patients with cardiovascular disease. Progenitor Cell Measures. CD34+ cell measurements will take place in","text_display":" patients with cardiovascular disease. Progenitor Cell Measures. CD34+ cell measurements will take place in","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1927,425],[1927,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1808,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae3b380f7146491d9c1e24b246a4445b","type":"text","conversion_output":true,"text":"Dr. Losordo's laboratory using methods implemented for our pilot study (see sections C1b and C1c). Total","text_display":" Dr. Losordo's laboratory using methods implemented for our pilot study (see sections C1b and C1c). Total","confidence":1,"confidence_rate":1},{"cnt":[[120,471],[1985,471],[1985,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1866,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d0ef823aa3e540cca41bbb6a35dce580","type":"text","conversion_output":true,"text":"human peripheral blood mononuclear cells (MNCs) are isolated from the blood of participants by Ficoll density","text_display":" human peripheral blood mononuclear cells (MNCs) are isolated from the blood of participants by Ficoll density","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1927,516],[1927,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1808,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7ee5cd8069e405797a854823cb8e272","type":"text","conversion_output":true,"text":"gradient centrifugation with Histopaque-1077 (Sigma), according to the manufacturer's instructions. Briefly,","text_display":" gradient centrifugation with Histopaque-1077 (Sigma), according to the manufacturer's instructions. Briefly,","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[120,559],[1944,559],[1944,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1825,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2328aa4881464b16aa4140463596da4c","type":"text","conversion_output":true,"text":"MNCs are aliquoted ( \\(5 \\times 10^{5}\\) ) to an Aldecount tube, incubated with BODIPY-AAD for 30 minutes at \\(37^{\\circ} C\\), and","text_display":" MNCs are aliquoted ( \\(5 \\times 10^{5}\\) ) to an Aldecount tube, incubated with BODIPY-AAD for 30 minutes at \\(37^{\\circ} C\\), and","confidence":0.763671875,"confidence_rate":0.9980194853928732},{"cnt":[[120,602],[1953,602],[1953,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1833,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c0396dde925420d96b8fb835ecde781","type":"text","conversion_output":true,"text":"maintained on ice to prevent fluorescent byproduct exiting cells. Cells are washed in ALDH assay buffer at 4","text_display":" maintained on ice to prevent fluorescent byproduct exiting cells. Cells are washed in ALDH assay buffer at 4","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1987,645],[1987,690],[120,690]],"region":{"top_left_x":120,"top_left_y":644,"width":1868,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd1d6c045cda4cc6b227c8a5e60f381f","type":"text","conversion_output":true,"text":"degrees Celsius for 5 minutes and re-suspended in 90ul ALDH Assay buffer for further staining. ALDH labeled","text_display":" degrees Celsius for 5 minutes and re-suspended in 90ul ALDH Assay buffer for further staining. ALDH labeled","confidence":0.99853515625,"confidence_rate":0.9999872529709615},{"cnt":[[120,690],[1931,690],[1931,735],[120,735]],"region":{"top_left_x":120,"top_left_y":689,"width":1812,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5046fda5ab8c4837ab49fb87165b713a","type":"text","conversion_output":true,"text":"MNCs are incubated with FcR Blocking Reagent (Miltenyi Biotec) for 10 minutes followed by specific FACS","text_display":" MNCs are incubated with FcR Blocking Reagent (Miltenyi Biotec) for 10 minutes followed by specific FACS","confidence":0.9931700215674937,"confidence_rate":0.9999382594782299},{"cnt":[[120,735],[1962,735],[1962,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1842,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"91b4d1f3aa1246a199fbd7877d82f8fb","type":"text","conversion_output":true,"text":"antibodies for 30 minutes on ice to identify the CD34-PE Cy7 (Beckman Coulter) endothelial marker (primary","text_display":" antibodies for 30 minutes on ice to identify the CD34-PE Cy7 (Beckman Coulter) endothelial marker (primary","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1899,778],[1899,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1780,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"076d64aa2bcd41f3846d5ae921aa3aed","type":"text","conversion_output":true,"text":"outcome) and other cell surface markers (exploratory outcomes). These exploratory cell markers include","text_display":" outcome) and other cell surface markers (exploratory outcomes). These exploratory cell markers include","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1970,821],[1970,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1851,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"305623d9c09b438d8d99b321be8ad792","type":"text","conversion_output":true,"text":"CD133-APC (Miltenyi Biotec) and VEGF R2 / KDR-PE (R\\&D Biosystems). Dead and dying cells are excluded","text_display":" CD133-APC (Miltenyi Biotec) and VEGF R2 / KDR-PE (R\\&D Biosystems). Dead and dying cells are excluded","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[120,866],[2002,866],[2002,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1883,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01ab37c60c5f4cd09ec2879cbbd1313b","type":"text","conversion_output":true,"text":"using staining with 7-AAD ( \\(1 \\mu g / 10^{6}\\) cells; Invitrogen). Directly conjugated isotype control antibodies are used to","text_display":" using staining with 7-AAD ( \\(1 \\mu g / 10^{6}\\) cells; Invitrogen). Directly conjugated isotype control antibodies are used to","confidence":0.9060004198015577,"confidence_rate":0.9992524347966429},{"cnt":[[120,911],[1886,911],[1886,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1767,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7b883de068d4b5a969da6f010d92ee5","type":"text","conversion_output":true,"text":"set baseline fluorescence levels. Flow cytometry is performed by Northwestern's Cancer Core Research","text_display":" set baseline fluorescence levels. Flow cytometry is performed by Northwestern's Cancer Core Research","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1940,954],[1940,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1821,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42252db2a4584c09a762a39ce6a50a4c","type":"text","conversion_output":true,"text":"facility, blinded to patient identity and group assignment using the DakoCytomation CyAn FACS instrument.","text_display":" facility, blinded to patient identity and group assignment using the DakoCytomation CyAn FACS instrument.","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1953,997],[1953,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1833,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c358ac165df4814adb01185d37212ad","type":"text","conversion_output":true,"text":"Analyses are performed using the FlowJo software (Treestar). Gating mononuclear cells is performed on the","text_display":" Analyses are performed using the FlowJo software (Treestar). Gating mononuclear cells is performed on the","confidence":1,"confidence_rate":1},{"cnt":[[120,1042],[1790,1042],[1790,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1041,"width":1670,"height":47},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbcd3aef330245018c0c515bb7441ba1","type":"text","conversion_output":true,"text":"basis of light-scattering properties. The labeled cells of interest (i.e. CD34+ cells) are expressed as","text_display":" basis of light-scattering properties. The labeled cells of interest (i.e. CD34+ cells) are expressed as","confidence":1,"confidence_rate":1},{"cnt":[[120,1087],[1979,1087],[1979,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1859,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3617ff86b38a4e79b0aded46d16e0a36","type":"text","conversion_output":true,"text":"percentages of live mononuclear cells. Progenitor cell colony forming unit assay. Total human peripheral","text_display":" percentages of live mononuclear cells. Progenitor cell colony forming unit assay. Total human peripheral","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[120,1130],[1914,1130],[1914,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1795,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c81b5aabfcbd455390c15cc1bdf59055","type":"text","conversion_output":true,"text":"blood mononuclear cells (PBMNC) will be isolated from blood by Ficoll density gradient centrifugation with","text_display":" blood mononuclear cells (PBMNC) will be isolated from blood by Ficoll density gradient centrifugation with","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1979,1173],[1979,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1859,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9671789f233f4a18bc8be12eb371fc26","type":"text","conversion_output":true,"text":"Histopaque-1077 (Sigma) according to manufacturer instructions. PBMNC will be re-suspended in endothelial","text_display":" Histopaque-1077 (Sigma) according to manufacturer instructions. PBMNC will be re-suspended in endothelial","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[2000,1216],[2000,1261],[120,1261]],"region":{"top_left_x":120,"top_left_y":1216,"width":1881,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a266357503d94628a81cb32d405bc3a3","type":"text","conversion_output":true,"text":"cell basal medium-2 (EBM-2, Clonetics) supplemented with \\(5 \\%\\) FBS, human vascular endothelial growth factor","text_display":" cell basal medium-2 (EBM-2, Clonetics) supplemented with \\(5 \\%\\) FBS, human vascular endothelial growth factor","confidence":0.9736328125,"confidence_rate":0.9997635586147454},{"cnt":[[120,1261],[1888,1261],[1888,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1261,"width":1769,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16bc2669631e4c808fd22e550cad6d01","type":"text","conversion_output":true,"text":"(VEGF)-A, human fibroblast growth factor-2, human epidermal growth factor, insulin-like growth factor-1,","text_display":" (VEGF)-A, human fibroblast growth factor-2, human epidermal growth factor, insulin-like growth factor-1,","confidence":1,"confidence_rate":1},{"cnt":[[120,1306],[1987,1306],[1987,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1306,"width":1868,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"67a23c07be5a4a72a5bf001951a2848b","type":"text","conversion_output":true,"text":"ascorbic acid, and antibiotics and then plated on fibronectin-coated 6 well plates at a concentration of 5 million","text_display":" ascorbic acid, and antibiotics and then plated on fibronectin-coated 6 well plates at a concentration of 5 million","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1951,1349],[1951,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1831,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94b2c45b65d945559bc433c827e1204c","type":"text","conversion_output":true,"text":"cells per well. The endothelial colonies will be counted manually on day 7 by two investigators blinded to the","text_display":" cells per well. The endothelial colonies will be counted manually on day 7 by two investigators blinded to the","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1919,1392],[1919,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1799,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35cae2a8fe44426a87fce8f149bc71d8","type":"text","conversion_output":true,"text":"study group assignments. Progenitor cells will be further characterized by dual-staining for Dil-Ac-LDL and","text_display":" study group assignments. Progenitor cells will be further characterized by dual-staining for Dil-Ac-LDL and","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,1437],[1843,1437],[1843,1480],[120,1480]],"region":{"top_left_x":120,"top_left_y":1437,"width":1724,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1b355eb927c48db80bac88aa2d02c41","type":"text","conversion_output":true,"text":"Lectin and by the expression of endothelial marker proteins VEGFR-2, VE-cadherin, eNOS, and vWF.","text_display":" Lectin and by the expression of endothelial marker proteins VEGFR-2, VE-cadherin, eNOS, and vWF.","confidence":1,"confidence_rate":1},{"cnt":[[122,1525],[1987,1525],[1987,1571],[122,1571]],"region":{"top_left_x":122,"top_left_y":1525,"width":1866,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f3680e5bef8043debefea7d682043afa","type":"text","conversion_output":true,"text":"In addition to measuring progenitor cells at the frequency shown in Table 6 above, in up to 50 participants with","text_display":"\n\nIn addition to measuring progenitor cells at the frequency shown in Table 6 above, in up to 50 participants with","confidence":0.9926791191101074,"confidence_rate":0.999940263491215},{"cnt":[[122,1568],[1979,1568],[1979,1613],[122,1613]],"region":{"top_left_x":122,"top_left_y":1568,"width":1857,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8559d41e08a431ea45135976aee79e3","type":"text","conversion_output":true,"text":"PAD we will measure progenitor cell levels before and immediately following the treadmill exercise stress test.","text_display":" PAD we will measure progenitor cell levels before and immediately following the treadmill exercise stress test.","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[1968,1611],[1968,1659],[120,1659]],"region":{"top_left_x":120,"top_left_y":1611,"width":1848,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5854549655f7495d8addfd2dac7a2673","type":"text","conversion_output":true,"text":"We may also measure progenitor cell levels one hour post-exercise and one day post-exercise. The treadmill","text_display":" We may also measure progenitor cell levels one hour post-exercise and one day post-exercise. The treadmill","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,1656],[1996,1656],[1996,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1656,"width":1876,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9387c0845c04dd083c04012efc62ace","type":"text","conversion_output":true,"text":"exercise stress test at which this may occur may be affiliated with any of the visits shown in Table 6. However,","text_display":" exercise stress test at which this may occur may be affiliated with any of the visits shown in Table 6. However,","confidence":1,"confidence_rate":1},{"cnt":[[120,1699],[1966,1699],[1966,1745],[120,1745]],"region":{"top_left_x":120,"top_left_y":1699,"width":1846,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5c8d51bad1b412886f3322ba40982d3","type":"text","conversion_output":true,"text":"it is possible that the participant may be asked to undergo an additional treadmill exercise stress test in order","text_display":" it is possible that the participant may be asked to undergo an additional treadmill exercise stress test in order","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[1910,1745],[1910,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1790,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30b9ac9da6a449788ddd864386a23313","type":"text","conversion_output":true,"text":"to expedite collecting data on progenitor cell levels before and after an exercise stress test. Also- up to 30","text_display":" to expedite collecting data on progenitor cell levels before and after an exercise stress test. Also- up to 30","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1962,1788],[1962,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1842,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a91ccd04a6d48378ea51e9fb543d9d8","type":"text","conversion_output":true,"text":"participants who are determined ineligible for the study due to absence of PAD will be invited to participate in","text_display":" participants who are determined ineligible for the study due to absence of PAD will be invited to participate in","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1910,1830],[1910,1876],[120,1876]],"region":{"top_left_x":120,"top_left_y":1830,"width":1790,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae7334956daa495787d45fc9394beef0","type":"text","conversion_output":true,"text":"an exercise treadmill stress test. Levels of progenitor cells will be measured before and after the exercise","text_display":" an exercise treadmill stress test. Levels of progenitor cells will be measured before and after the exercise","confidence":0.9990234375,"confidence_rate":0.9999913536688149},{"cnt":[[120,1876],[1906,1876],[1906,1921],[120,1921]],"region":{"top_left_x":120,"top_left_y":1875,"width":1786,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7481b162fa014ac08a74f2a7387e5a88","type":"text","conversion_output":true,"text":"treadmill stress test in these individuals without PAD as well as one hour post-exercise and one day post-","text_display":" treadmill stress test in these individuals without PAD as well as one hour post-exercise and one day post","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,1921],[1695,1921],[1695,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1920,"width":1576,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddaa17bf666148b2a179e3d069f3819e","type":"text","conversion_output":true,"text":"exercise. These additional procedures will allow us to achieve our exploratory aim \\#5 above.","text_display":"exercise. These additional procedures will allow us to achieve our exploratory aim \\#5 above.","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[122,2007],[1953,2007],[1953,2052],[122,2052]],"region":{"top_left_x":122,"top_left_y":2006,"width":1831,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb4acec277ef455fb038a3a88a2dd642","type":"text","conversion_output":true,"text":"C12. Six-minute walk. Our primary outcome is change in the distance achieved in the six-minute walk test","text_display":"\n\nC12. Six-minute walk. Our primary outcome is change in the distance achieved in the six-minute walk test","confidence":1,"confidence_rate":1},{"cnt":[[120,2097],[120,2049],[1936,2052],[1936,2100]],"region":{"top_left_x":120,"top_left_y":2048,"width":1816,"height":52},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c5b3168ca554254946a57c08c5fbb81","type":"text","conversion_output":true,"text":"between baseline and 12 -week follow-up. The six-minute walk is our primary outcome measure for several","text_display":" between baseline and 12 -week follow-up. The six-minute walk is our primary outcome measure for several","confidence":0.751953125,"confidence_rate":0.9974349953438727},{"cnt":[[120,2095],[1938,2095],[1938,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2094,"width":1818,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bfc2c4734fe4e319c8f8ee627fb34d2","type":"text","conversion_output":true,"text":"reasons. First, our work demonstrates that for PAD participants, performance on the six-minute walk test is","text_display":" reasons. First, our work demonstrates that for PAD participants, performance on the six-minute walk test is","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1923,2140],[1923,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1803,"height":46},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d479b026d15b47fb9742ed03cf2b2e99","type":"text","conversion_output":true,"text":"more closely correlated with walking performance during daily life than treadmill walking performance (81).","text_display":" more closely correlated with walking performance during daily life than treadmill walking performance (81).","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1970,2183],[1970,2228],[120,2228]],"region":{"top_left_x":120,"top_left_y":2182,"width":1851,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d5351ea1bab4fcab634d3329241cbd0","type":"text","conversion_output":true,"text":"Secondly, for elderly patients, such as those with PAD, treadmill walking is associated with balance problems","text_display":" Secondly, for elderly patients, such as those with PAD, treadmill walking is associated with balance problems","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1904,2226],[1904,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2225,"width":1784,"height":49},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6df73a5d05c04211847d7f26b023e3ec","type":"text","conversion_output":true,"text":"and anxiety (52-54). A previous study of 12 healthy elderly volunteers (ages \\(71-80\\) years) and 12 healthy","text_display":" and anxiety (52-54). A previous study of 12 healthy elderly volunteers (ages \\(71-80\\) years) and 12 healthy","confidence":0.44930076599121094,"confidence_rate":0.9932427407819995},{"cnt":[[120,2271],[1886,2271],[1886,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1767,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d98472f351740cfb842140ef041eb7a","type":"text","conversion_output":true,"text":"young volunteers (ages 21-37) compared physiologic responses and steps per minute during a treadmill","text_display":" young volunteers (ages 21-37) compared physiologic responses and steps per minute during a treadmill","confidence":0.99755859375,"confidence_rate":0.9999767203534344},{"cnt":[[120,2314],[1893,2314],[1893,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2313,"width":1773,"height":49},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"55e575ec2e984e7e8b4f2fbd748151c8","type":"text","conversion_output":true,"text":"exercise test vs. the six-minute walk (corridor walking) performed on three separate occasions (52). The","text_display":" exercise test vs. the six-minute walk (corridor walking) performed on three separate occasions (52). The","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[120,2359],[1949,2359],[1949,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1829,"height":47},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de8e14b6465a4fd6a2c33473fef75004","type":"text","conversion_output":true,"text":"elderly group, but not the younger group, had consistently higher heart rates and lower step rates during the","text_display":" elderly group, but not the younger group, had consistently higher heart rates and lower step rates during the","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1882,2402],[1882,2447],[120,2447]],"region":{"top_left_x":120,"top_left_y":2401,"width":1763,"height":47},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f50d594a08b4f418401cf59660ac418","type":"text","conversion_output":true,"text":"treadmill test than during the corridor walks (52). Third, treadmill walking is associated with a significant","text_display":" treadmill test than during the corridor walks (52). Third, treadmill walking is associated with a significant","confidence":0.9926819801330566,"confidence_rate":0.9999355728831427},{"cnt":[[120,2445],[2000,2445],[2000,2494],[120,2494]],"region":{"top_left_x":120,"top_left_y":2444,"width":1881,"height":51},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9180015b12c4b14afa413ec43d92f7d","type":"text","conversion_output":true,"text":"learning effect (82-84). Supervised treadmill exercise interventions, such as that proposed in the current study,","text_display":" learning effect (82-84). Supervised treadmill exercise interventions, such as that proposed in the current study,","confidence":0.99755859375,"confidence_rate":0.9999792850336954},{"cnt":[[120,2488],[1936,2488],[1936,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":1816,"height":51},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e4505fd1324435b894a5f4c12aa6099","type":"text","conversion_output":true,"text":"can improve treadmill walking performance in part because of the \"practice\" associated with the three times","text_display":" can improve treadmill walking performance in part because of the \"practice\" associated with the three times","confidence":1,"confidence_rate":1},{"cnt":[[120,2535],[1914,2535],[1914,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2535,"width":1795,"height":46},"line":54,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7e4d413f33f4b5aa08640af1fc2bc05","type":"text","conversion_output":true,"text":"weekly treadmill exercise sessions. In the six-minute walk, participants walk back and forth along a \\(100- ft\\)","text_display":" weekly treadmill exercise sessions. In the six-minute walk, participants walk back and forth along a \\(100- ft\\)","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":55,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1995598695e04dc4ad7688bd96147113","type":"page_info","conversion_output":false,"text":"13","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-14","page":14,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e55b7058bd0f46bfa526f85789d6efa3","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,165],[1738,165]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"53f1db2426404dcf9056324fec2b0955","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1876,206],[1876,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1756,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88c68c3f69aa4b4e84b3b60216bde898","type":"text","conversion_output":true,"text":"hallway for six minutes after standardized instructions to complete as many laps as possible ( \\(44,81,85\\) ).","text_display":"\nhallway for six minutes after standardized instructions to complete as many laps as possible ( \\(44,81,85\\) ).","confidence":0.6405179500579834,"confidence_rate":0.9960999222148067},{"cnt":[[120,249],[1979,249],[1979,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1859,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf380401051046af81b27e69deef0569","type":"text","conversion_output":true,"text":"Distance covered in six minutes is recorded. The intra-class correlation coefficient for the test-retest reliability","text_display":" Distance covered in six minutes is recorded. The intra-class correlation coefficient for the test-retest reliability","confidence":1,"confidence_rate":1},{"cnt":[[120,294],[2004,294],[2004,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1885,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed74d3197f25438fa9ce98f56b63bcca","type":"text","conversion_output":true,"text":"of the six-minute walk test among 156 PAD participants in our SILC exercise trial was 0.90 ( \\(p <0.001\\) ) when two","text_display":" of the six-minute walk test among 156 PAD participants in our SILC exercise trial was 0.90 ( \\(p <0.001\\) ) when two","confidence":0.67578125,"confidence_rate":0.996943073740101},{"cnt":[[120,339],[1253,339],[1253,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1133,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c264eb3deaf4ce09cb2cc41549a6d82","type":"text","conversion_output":true,"text":"six-minute walk tests were completed one to two weeks apart (44).","text_display":" six-minute walk tests were completed one to two weeks apart (44).","confidence":0.99560546875,"confidence_rate":0.9999370846137567},{"cnt":[[120,425],[1876,425],[1876,475],[120,475]],"region":{"top_left_x":120,"top_left_y":425,"width":1756,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c3ba81def60241e29f182cf32baef0ab","type":"text","conversion_output":true,"text":"C13. Treadmill testing. The Gardner graded treadmill exercise test is the standard, accepted treadmill","text_display":"\n\nC13. Treadmill testing. The Gardner graded treadmill exercise test is the standard, accepted treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,471],[1910,471],[1910,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1790,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c323677cfc684c0bb5b846541fe72ce8","type":"text","conversion_output":true,"text":"protocol for measuring change in maximal treadmill walking time in response to interventions among PAD","text_display":" protocol for measuring change in maximal treadmill walking time in response to interventions among PAD","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1936,516],[1936,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1816,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9fc23df42e342f6a725386bf1a2409d","type":"text","conversion_output":true,"text":"participants (82-84). The FDA requires treadmill evidence when evaluating therapeutic drugs for improving","text_display":" participants (82-84). The FDA requires treadmill evidence when evaluating therapeutic drugs for improving","confidence":0.9946370096877217,"confidence_rate":0.9999511155333508},{"cnt":[[120,559],[1912,559],[1912,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1793,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77e8003eec6d4c85bb55b815dcc48732","type":"text","conversion_output":true,"text":"walking performance in PAD. In the Gardner exercise protocol, speed is maintained at 2.0 miles per hour","text_display":" walking performance in PAD. In the Gardner exercise protocol, speed is maintained at 2.0 miles per hour","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,602],[1953,602],[1953,649],[120,649]],"region":{"top_left_x":120,"top_left_y":601,"width":1833,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"268fa64e5f434884bd0f6a133eb255cb","type":"text","conversion_output":true,"text":"\\(( mph )\\) and treadmill grade increases by \\(2.0 \\%\\) every two minutes (82-84). If patients cannot walk at 2.0 mph ,","text_display":" \\(( mph )\\) and treadmill grade increases by \\(2.0 \\%\\) every two minutes (82-84). If patients cannot walk at 2.0 mph ,","confidence":0.9409106437578885,"confidence_rate":0.9995008860519616},{"cnt":[[120,645],[1996,645],[1996,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1876,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dbcb2828826436c986e910493334bf0","type":"text","conversion_output":true,"text":"treadmill speed is started at 0.50 mph and increased by 0.50 mph every 2 minutes until the participant reaches","text_display":" treadmill speed is started at 0.50 mph and increased by 0.50 mph every 2 minutes until the participant reaches","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1343,690],[1343,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1223,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6564d19438944636984bc19ee99a4c11","type":"text","conversion_output":true,"text":"2.0 mph , after which the treadmill grade is increased every two minutes.","text_display":" 2.0 mph , after which the treadmill grade is increased every two minutes.","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1912,778],[1912,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1793,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0806d38e8c0040f0b3e3762e2395f6ec","type":"text","conversion_output":true,"text":"C14. Brachial Artery Flow-Mediated Dilation (FMD). As in our prior studies ( \\(44,86,87\\) ), brachial artery","text_display":"\n\nC14. Brachial Artery Flow-Mediated Dilation (FMD). As in our prior studies ( \\(44,86,87\\) ), brachial artery","confidence":0.9985356330871582,"confidence_rate":0.9999869157985816},{"cnt":[[120,821],[1972,821],[1972,868],[120,868]],"region":{"top_left_x":120,"top_left_y":820,"width":1853,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"993108725a954acfbe4ae2d942b4f236","type":"text","conversion_output":true,"text":"imaging will be performed by a Registered Diagnostic Cardiac Sonographer \\((44,86,87)\\). Participants withhold","text_display":" imaging will be performed by a Registered Diagnostic Cardiac Sonographer \\((44,86,87)\\). Participants withhold","confidence":0.5617372989654541,"confidence_rate":0.9949975889169483},{"cnt":[[120,866],[1962,866],[1962,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1842,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e132cf6115eb4b688861b9d1c4c5b672","type":"text","conversion_output":true,"text":"vasoactive medications, refrain from smoking, and fast prior to testing \\((86,86)\\). With the participant supine, a","text_display":" vasoactive medications, refrain from smoking, and fast prior to testing \\((86,86)\\). With the participant supine, a","confidence":0.9736328125,"confidence_rate":0.9997773494933238},{"cnt":[[120,911],[1901,911],[1901,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1782,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c344fca8b34f41f79eb761e4305a7587","type":"text","conversion_output":true,"text":"blood pressure cuff over the upper arm is inflated for four minutes. The inflation pressure is systolic blood","text_display":" blood pressure cuff over the upper arm is inflated for four minutes. The inflation pressure is systolic blood","confidence":0.99755859375,"confidence_rate":0.9999785582005648},{"cnt":[[120,954],[1858,954],[1858,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1739,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d13d4e6a2dd4eb987199cb6905272be","type":"text","conversion_output":true,"text":"pressure (SBP) +50 mmHg . The brachial artery is imaged (B-mode and Doppler) 5 to 9 cm above the","text_display":" pressure (SBP) +50 mmHg . The brachial artery is imaged (B-mode and Doppler) 5 to 9 cm above the","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[120,997],[1927,997],[1927,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1808,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8251fa7ff5b245ea81fe7d3697e32d3e","type":"text","conversion_output":true,"text":"antecubital fossa using a linear array vascular ultrasound transducer (Siemens Medical Solutions, Sequoia","text_display":" antecubital fossa using a linear array vascular ultrasound transducer (Siemens Medical Solutions, Sequoia","confidence":1,"confidence_rate":1},{"cnt":[[120,1042],[1876,1042],[1876,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1041,"width":1756,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"079df4c57afe4026b426dfaf839d3c62","type":"text","conversion_output":true,"text":"Model \\#256, frequency 8 MHz ). Three video sequences are obtained. The first verifies the location and","text_display":" Model \\#256, frequency 8 MHz ). Three video sequences are obtained. The first verifies the location and","confidence":1,"confidence_rate":1},{"cnt":[[120,1085],[1944,1085],[1944,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1084,"width":1825,"height":49},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec59ec90b1c3478aa50a20b0f516098a","type":"text","conversion_output":true,"text":"baseline hemodynamic state of the brachial artery. The second begins 20 seconds before cuff inflation and","text_display":" baseline hemodynamic state of the brachial artery. The second begins 20 seconds before cuff inflation and","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1979,1130],[1979,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1859,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0237ea67cf7647e186bc677ae5d8adaa","type":"text","conversion_output":true,"text":"continues for 10 seconds after inflation. The third begins 15 seconds before cuff release and continues for 90","text_display":" continues for 10 seconds after inflation. The third begins 15 seconds before cuff release and continues for 90","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1992,1173],[1992,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1872,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b57513bd15d142e3ae84266512d4b081","type":"text","conversion_output":true,"text":"seconds after deflation. Brachial artery FMD is calculated as the percent change in brachial artery diameter at","text_display":" seconds after deflation. Brachial artery FMD is calculated as the percent change in brachial artery diameter at","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[1854,1216],[1854,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1735,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a9c055b09e24b1b8164ee45db60af42","type":"text","conversion_output":true,"text":"60 seconds after the release of the cuff. Because previous studies of coronary artery disease patients","text_display":" 60 seconds after the release of the cuff. Because previous studies of coronary artery disease patients","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,1261],[1863,1261],[1863,1306],[120,1306]],"region":{"top_left_x":120,"top_left_y":1261,"width":1743,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39494f4ecec74dd6b76cbc3be831c859","type":"text","conversion_output":true,"text":"consistently show that brachial artery endothelial independent function does not change in response to","text_display":" consistently show that brachial artery endothelial independent function does not change in response to","confidence":1,"confidence_rate":1},{"cnt":[[120,1306],[2004,1306],[2004,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1306,"width":1885,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9437283ec79144abb2e2564106b97747","type":"text","conversion_output":true,"text":"interventions, we will not measure nitroglycerin-mediated vasodilation \\((89,90)\\). Changes in brachial artery FMD","text_display":" interventions, we will not measure nitroglycerin-mediated vasodilation \\((89,90)\\). Changes in brachial artery FMD","confidence":0.67041015625,"confidence_rate":0.9966454242429394},{"cnt":[[120,1349],[1931,1349],[1931,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1812,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e03bf31adb4541efb4e16de82113613d","type":"text","conversion_output":true,"text":"will be read by Dr. James Stein's University of Wisconsin Atherosclerosis Imaging Research Program Core","text_display":" will be read by Dr. James Stein's University of Wisconsin Atherosclerosis Imaging Research Program Core","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1824,1392],[1824,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1705,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa1842b252ca4f709568af63134822d5","type":"text","conversion_output":true,"text":"Laboratory. Images are read by a single reader blinded to participant characteristics. Measurement","text_display":" Laboratory. Images are read by a single reader blinded to participant characteristics. Measurement","confidence":1,"confidence_rate":1},{"cnt":[[120,1437],[1923,1437],[1923,1482],[120,1482]],"region":{"top_left_x":120,"top_left_y":1437,"width":1803,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8c6fb873d6f4264aabe2ad2c2a36b82","type":"text","conversion_output":true,"text":"reproducibility in Dr. Stein's laboratory has a median FMD difference of \\(0.02 \\%\\) (inter-quartile range: \\(-0.03-\\)","text_display":" reproducibility in Dr. Stein's laboratory has a median FMD difference of \\(0.02 \\%\\) (inter-quartile range: \\(-0.03-\\)","confidence":0.5976843086966921,"confidence_rate":0.9955344128972734},{"cnt":[[120,1482],[226,1482],[226,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1482,"width":106,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5edbf798847a40aa8387c00d13084210","type":"text","conversion_output":true,"text":"0.04).","text_display":" 0.04).","confidence":0.9921875,"confidence_rate":0.9992872380027777},{"cnt":[[120,1568],[1998,1568],[1998,1613],[120,1613]],"region":{"top_left_x":120,"top_left_y":1568,"width":1879,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c70d01ac5c5c4e3c90bf13add47b27c1","type":"text","conversion_output":true,"text":"C15. Other measures. As in our previous clinical trials, patient report will be used to document comorbidities.","text_display":"\n\nC15. Other measures. As in our previous clinical trials, patient report will be used to document comorbidities.","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[1899,1611],[1899,1659],[120,1659]],"region":{"top_left_x":120,"top_left_y":1611,"width":1780,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f713d73e488b44619f998c5c5a8185e7","type":"text","conversion_output":true,"text":"Patient reported comorbid disease is highly correlated with presence of comorbid disease measured with","text_display":" Patient reported comorbid disease is highly correlated with presence of comorbid disease measured with","confidence":1,"confidence_rate":1},{"cnt":[[120,1656],[1981,1656],[1981,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1656,"width":1861,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c2e77dccfed44145840e57dbe2cc9fba","type":"text","conversion_output":true,"text":"medical record review (91-95). In the National Hospital Discharge Survey of 122 elderly men and women, the","text_display":" medical record review (91-95). In the National Hospital Discharge Survey of 122 elderly men and women, the","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[120,1702],[1931,1702],[1931,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1701,"width":1812,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0de55a0873942a480463aaa218aaaf7","type":"text","conversion_output":true,"text":"percent agreement between patient report and medical record review was 85\\% for angina, 89\\% for cancer,","text_display":" percent agreement between patient report and medical record review was 85\\% for angina, 89\\% for cancer,","confidence":0.7877011299133301,"confidence_rate":0.9977722371381809},{"cnt":[[120,1745],[1938,1745],[1938,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1818,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d8b0a8e968c4c3b8bb764556a541c14","type":"text","conversion_output":true,"text":"\\(98 \\%\\) for diabetes, \\(94 \\%\\) for myocardial infarction, and \\(98 \\%\\) for stroke (92). Participants will be asked to bring","text_display":" \\(98 \\%\\) for diabetes, \\(94 \\%\\) for myocardial infarction, and \\(98 \\%\\) for stroke (92). Participants will be asked to bring","confidence":0.7414358831186563,"confidence_rate":0.9974891525034376},{"cnt":[[120,1788],[1974,1788],[1974,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1855,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c97570965b1b48ee830546addf0c6510","type":"text","conversion_output":true,"text":"their medication bottles for assessment of medication use at baseline and at follow-up visits. Patient-report is","text_display":" their medication bottles for assessment of medication use at baseline and at follow-up visits. Patient-report is","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1201,1830],[1201,1880],[120,1880]],"region":{"top_left_x":120,"top_left_y":1830,"width":1081,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66c51fb3c29143e5b8320c21220b3abd","type":"text","conversion_output":true,"text":"an accurate measure of cigarette smoking in PAD patients (96).","text_display":" an accurate measure of cigarette smoking in PAD patients (96).","confidence":1,"confidence_rate":1},{"cnt":[[120,1921],[2000,1921],[2000,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1920,"width":1881,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef5c77c29ca045d5b1b312d0761a730f","type":"text","conversion_output":true,"text":"Some or all study measures may be repeated at baseline or follow-up for data quality (one potential example is","text_display":"\n\nSome or all study measures may be repeated at baseline or follow-up for data quality (one potential example is","confidence":1,"confidence_rate":1},{"cnt":[[120,1964],[1992,1964],[1992,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1872,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd4d311a5be645a2a00aabb7a7d417c2","type":"text","conversion_output":true,"text":"if a treadmill test must be stopped due to extremely high blood pressure before the patient completed the test).","text_display":" if a treadmill test must be stopped due to extremely high blood pressure before the patient completed the test).","confidence":1,"confidence_rate":1},{"cnt":[[120,2093],[1955,2093],[1955,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2092,"width":1836,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a91cba3720944aa89c774a0af8448259","type":"text","conversion_output":true,"text":"C16. Quality Control. As in our prior studies, health interviewers will be trained by a senior coordinator and","text_display":"\n\nC16. Quality Control. As in our prior studies, health interviewers will be trained by a senior coordinator and","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[120,2140],[1955,2140],[1955,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1836,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9106d7838e648109a4c94d8c52eb4d1","type":"text","conversion_output":true,"text":"certified by Dr. McDermott in each component of data collection, using a detailed checklist developed for the","text_display":" certified by Dr. McDermott in each component of data collection, using a detailed checklist developed for the","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1955,2183],[1955,2228],[120,2228]],"region":{"top_left_x":120,"top_left_y":2182,"width":1836,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb8a70a12a8d479cacee281b401bb47b","type":"text","conversion_output":true,"text":"study (see Appendix A for example checklist). Health interviewers are rigorously evaluated for adherence to","text_display":" study (see Appendix A for example checklist). Health interviewers are rigorously evaluated for adherence to","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1852,2226],[1852,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2225,"width":1732,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f6df63bee734562a54276c6b62c90b2","type":"text","conversion_output":true,"text":"protocol, delineated in our manuals, prior to beginning data collection and every six months after initial","text_display":" protocol, delineated in our manuals, prior to beginning data collection and every six months after initial","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[2002,2271],[2002,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1883,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e0c0cc3cfb945fba5d85e601fe9b4b9","type":"text","conversion_output":true,"text":"certification. When deficiencies are identified, interviewers undergo additional training and re-assessment. Ten","text_display":" certification. When deficiencies are identified, interviewers undergo additional training and re-assessment. Ten","confidence":1,"confidence_rate":1},{"cnt":[[120,2314],[1992,2314],[1992,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2313,"width":1872,"height":49},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"220c1dde75704494b2e0ca166b4294c0","type":"text","conversion_output":true,"text":"percent of participants are randomly identified for quality control. This subset has their ABI measured twice by","text_display":" percent of participants are randomly identified for quality control. This subset has their ABI measured twice by","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1962,2359],[1962,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1842,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a861e3af064842b8ad3033253ca7d54d","type":"text","conversion_output":true,"text":"independent examiners and has an extra blood sample obtained for quality control assessment of progenitor","text_display":" independent examiners and has an extra blood sample obtained for quality control assessment of progenitor","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1914,2402],[1914,2447],[120,2447]],"region":{"top_left_x":120,"top_left_y":2401,"width":1795,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6878d501bde44bf82a2437566566d0c","type":"text","conversion_output":true,"text":"cells. The second blood sample is designated an arbitrary identification number to which the technician is","text_display":" cells. The second blood sample is designated an arbitrary identification number to which the technician is","confidence":1,"confidence_rate":1},{"cnt":[[120,2492],[120,2443],[1992,2445],[1992,2494]],"region":{"top_left_x":120,"top_left_y":2443,"width":1872,"height":52},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b96865c0ad224195b9561a23c4e7c50f","type":"text","conversion_output":true,"text":"blinded. Thus, quality control is monitored continuously. A randomly selected \\(10 \\%\\) subset of exercise session","text_display":" blinded. Thus, quality control is monitored continuously. A randomly selected \\(10 \\%\\) subset of exercise session","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[120,2492],[1949,2492],[1949,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2492,"width":1829,"height":46},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e11dd9649fde497898d779051bed6c37","type":"text","conversion_output":true,"text":"charts will be reviewed by Dr. McDermott to ensure protocol adherence. Dr. McDermott also attends one or","text_display":" charts will be reviewed by Dr. McDermott to ensure protocol adherence. Dr. McDermott also attends one or","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[120,2535],[2000,2535],[2000,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2535,"width":1881,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8560877c4ce441cfa681a5ca909fde87","type":"text","conversion_output":true,"text":"more exercise sessions on a monthly basis to ensure adherence to protocol. Furthermore, during the first year","text_display":" more exercise sessions on a monthly basis to ensure adherence to protocol. Furthermore, during the first year","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5b9ffcbcb714e1baca8ab2f3c1e0dd6","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-15","page":15,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"76d7212bd52c4355b1708da86364325a","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,165],[1738,165]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cc81f6098ad146beba0a0dbb4f2861f0","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1996,206],[1996,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1876,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef708aa293c34177bd685bfe2440d9f8","type":"text","conversion_output":true,"text":"of the study, 10 participants will be selected for a second brachial artery FMD. These participants will be asked","text_display":"\nof the study, 10 participants will be selected for a second brachial artery FMD. These participants will be asked","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[1931,249],[1931,299],[120,299]],"region":{"top_left_x":120,"top_left_y":249,"width":1812,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb4c092c200a490a90cb6b6ea2e386c6","type":"text","conversion_output":true,"text":"to return within two weeks ( \\(1-14\\) days, but not on the same day as the first FMD) after their baseline testing","text_display":" to return within two weeks ( \\(1-14\\) days, but not on the same day as the first FMD) after their baseline testing","confidence":0.7236819685203955,"confidence_rate":0.9972630467698711},{"cnt":[[120,294],[1919,294],[1919,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1799,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"657940bfd07c48a1bb02f51932b92a4a","type":"text","conversion_output":true,"text":"and before randomization for a repeat brachial artery FMD measurement. The purpose of this re-test is to","text_display":" and before randomization for a repeat brachial artery FMD measurement. The purpose of this re-test is to","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1369,339],[1369,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1249,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ec0b7656d6e45a7906c91cda4bac477","type":"text","conversion_output":true,"text":"assess the test re-test reliability of the brachial artery FMD measurement.","text_display":" assess the test re-test reliability of the brachial artery FMD measurement.","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[2004,425],[2004,475],[120,475]],"region":{"top_left_x":120,"top_left_y":425,"width":1885,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"016b564ece164ca9a96e0d1b0b8f2d34","type":"text","conversion_output":true,"text":"C17. Blinding for data collection. The health interviewer collecting outcome data will be blinded to the study","text_display":"\n\nC17. Blinding for data collection. The health interviewer collecting outcome data will be blinded to the study","confidence":1,"confidence_rate":1},{"cnt":[[120,471],[1931,471],[1931,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1812,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8fdb9e29de249daac94ecb2bb4583e7","type":"text","conversion_output":true,"text":"group assignment. Participants are instructed not to reveal their group assignment. If a participant reveals","text_display":" group assignment. Participants are instructed not to reveal their group assignment. If a participant reveals","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1626,516],[1626,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1507,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bacaa744f5d646f0953980193c4dfb21","type":"text","conversion_output":true,"text":"their group assignment, another certified health interviewer is paged to continue the visit.","text_display":" their group assignment, another certified health interviewer is paged to continue the visit.","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1843,602],[1843,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1724,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c9395462b6114b4b98357045720e8183","type":"text","conversion_output":true,"text":"C18. Data Management. We will use methods in place for our previous and ongoing PAD studies to","text_display":"\n\nC18. Data Management. We will use methods in place for our previous and ongoing PAD studies to","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1979,645],[1979,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1859,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48cf708e7ebb4b9494b78a454fa2c362","type":"text","conversion_output":true,"text":"customize a data management system for the PROPEL Study. Data from baseline and follow-up visits will be","text_display":" customize a data management system for the PROPEL Study. Data from baseline and follow-up visits will be","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1985,690],[1985,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1866,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec2850ed0e434521ac361d969d9ae311","type":"text","conversion_output":true,"text":"acquired on paper and processed using the Teleform system by Cardiff Software. We have successfully used","text_display":" acquired on paper and processed using the Teleform system by Cardiff Software. We have successfully used","confidence":1,"confidence_rate":1},{"cnt":[[120,735],[1841,735],[1841,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1722,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1935c9404082405d885b1444acc439ac","type":"text","conversion_output":true,"text":"the Teleform system for over 6,000 patient visits in previous and ongoing studies. Teleform has three","text_display":" the Teleform system for over 6,000 patient visits in previous and ongoing studies. Teleform has three","confidence":0.9013671875,"confidence_rate":0.9990477695209568},{"cnt":[[120,778],[1983,778],[1983,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1864,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee3cf31b000a4e75ab96faa0cb4ccfca","type":"text","conversion_output":true,"text":"components. The first component, the Designer, functions as a page layout program with predefined tools for","text_display":" components. The first component, the Designer, functions as a page layout program with predefined tools for","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1962,821],[1962,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1842,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0dbaa14e5a14b178205cfb7e3b18125","type":"text","conversion_output":true,"text":"creating check boxes, bar code fields, and hand print fields. Form packets are assembled and individualized","text_display":" creating check boxes, bar code fields, and hand print fields. Form packets are assembled and individualized","confidence":1,"confidence_rate":1},{"cnt":[[120,866],[1910,866],[1910,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1790,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0999e6dcfdd4073b21e13fd56987b2c","type":"text","conversion_output":true,"text":"with ID labels prior to each visit. Completed forms are scanned using a high-speed scanner. The second","text_display":" with ID labels prior to each visit. Completed forms are scanned using a high-speed scanner. The second","confidence":1,"confidence_rate":1},{"cnt":[[120,907],[1919,907],[1919,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1799,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c267c9668b7543a9a0cc34c4b6e1a4b0","type":"text","conversion_output":true,"text":"component, the Reader, accepts scanned images and translates user responses (check marks, circles, or","text_display":" component, the Reader, accepts scanned images and translates user responses (check marks, circles, or","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1949,954],[1949,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1829,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ade90f3e0c04a18b1f4f4908e9079c6","type":"text","conversion_output":true,"text":"hand-printed text) into machine-readable responses. The third component, the Verifier, double-checks user","text_display":" hand-printed text) into machine-readable responses. The third component, the Verifier, double-checks user","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1914,997],[1914,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1795,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33c85ae79b8a449cbf027884da504205","type":"text","conversion_output":true,"text":"responses prior to final acceptance. The Verifier is programmed with the data validation rules established","text_display":" responses prior to final acceptance. The Verifier is programmed with the data validation rules established","confidence":1,"confidence_rate":1},{"cnt":[[120,1040],[1957,1040],[1957,1089],[120,1089]],"region":{"top_left_x":120,"top_left_y":1039,"width":1838,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0058d94e9fb44e188976c49268789fe0","type":"text","conversion_output":true,"text":"when the form was created. Data are routinely backed-up and copied to CDROM for secure off-site storage.","text_display":" when the form was created. Data are routinely backed-up and copied to CDROM for secure off-site storage.","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1985,1130],[1985,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1866,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a932367fe0844b9bc3dfdcc04a9ba31","type":"text","conversion_output":true,"text":"C19. Data and Safety Monitoring Board (DSMB). As per NHLBI guidelines, the DSMB will be appointed by","text_display":"\n\nC19. Data and Safety Monitoring Board (DSMB). As per NHLBI guidelines, the DSMB will be appointed by","confidence":0.998046875,"confidence_rate":0.9999813807939509},{"cnt":[[120,1173],[1931,1173],[1931,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1812,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"030e78d510534eaaba5db43311831d43","type":"text","conversion_output":true,"text":"the NHLBI. The DSMB will review and approve the protocol prior to beginning recruitment. The DSMB will","text_display":" the NHLBI. The DSMB will review and approve the protocol prior to beginning recruitment. The DSMB will","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[1876,1216],[1876,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1756,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0659ce114e704c37a0124e6a591e3a3a","type":"text","conversion_output":true,"text":"meet every six months. Adverse events will be monitored continuously throughout the study and will be","text_display":" meet every six months. Adverse events will be monitored continuously throughout the study and will be","confidence":1,"confidence_rate":1},{"cnt":[[120,1259],[1865,1259],[1865,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1258,"width":1745,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad1f9f57e0f6422489969a696d6ba3b6","type":"text","conversion_output":true,"text":"reported to the DSMB and IRB promptly. See Section D2 below for more information about the DSMB.","text_display":" reported to the DSMB and IRB promptly. See Section D2 below for more information about the DSMB.","confidence":1,"confidence_rate":1},{"cnt":[[120,1347],[1910,1347],[1910,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1347,"width":1790,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d398cce0e7c74c89b6ac6608169b48e2","type":"text","conversion_output":true,"text":"C20. Statistical Power Considerations. As indicated above, the four study arms are defined as follows:","text_display":"\n\nC20. Statistical Power Considerations. As indicated above, the four study arms are defined as follows:","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1919,1392],[1919,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1799,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc6b80a9146b487b94c9c177eb622f36","type":"text","conversion_output":true,"text":"Group A: GM-CSF combined with supervised treadmill exercise; Group B: GM-CSF therapy + an attention","text_display":" Group A: GM-CSF combined with supervised treadmill exercise; Group B: GM-CSF therapy + an attention","confidence":0.88916015625,"confidence_rate":0.9988710424984106},{"cnt":[[120,1435],[1983,1435],[1983,1485],[120,1485]],"region":{"top_left_x":120,"top_left_y":1435,"width":1864,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"104be69a987d4a8e83cc91528e6760a5","type":"text","conversion_output":true,"text":"control group; Group C: placebo + supervised exercise; and Group D: placebo + attention control group. From","text_display":" control group; Group C: placebo + supervised exercise; and Group D: placebo + attention control group. From","confidence":0.9863807594101672,"confidence_rate":0.9998775714843404},{"cnt":[[120,1480],[2002,1480],[2002,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1883,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c25a6ad2b2364d6bba8803e2e8986bbd","type":"text","conversion_output":true,"text":"this point forward, \"GM-CSF combined with supervised treadmill exercise\" refers to Group A; \"GM-CSF therapy","text_display":" this point forward, \"GM-CSF combined with supervised treadmill exercise\" refers to Group A; \"GM-CSF therapy","confidence":1,"confidence_rate":1},{"cnt":[[120,1523],[1893,1523],[1893,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1523,"width":1773,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c55f99b62ea64f9891fb051b26728767","type":"text","conversion_output":true,"text":"alone\" refers to Group B, \"supervised exercise therapy alone\" refers to Group C, and placebo + attention","text_display":" alone\" refers to Group B, \"supervised exercise therapy alone\" refers to Group C, and placebo + attention","confidence":0.5467842635948728,"confidence_rate":0.9946243139063393},{"cnt":[[120,1568],[1055,1568],[1055,1618],[120,1618]],"region":{"top_left_x":120,"top_left_y":1568,"width":935,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8335cc9dae054568b77e4412df794950","type":"text","conversion_output":true,"text":"control group (i.e. no active therapy) refers to Group D.","text_display":" control group (i.e. no active therapy) refers to Group D.","confidence":0.99951171875,"confidence_rate":0.999992122603638},{"cnt":[[120,1656],[1880,1656],[1880,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1656,"width":1760,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b75d5280c88e4b9f924ec4e318183fdb","type":"text","conversion_output":true,"text":"In our primary aim, we will determine at 12 -week follow-up: (a) whether GM-CSF therapy combined with","text_display":"\n\nIn our primary aim, we will determine at 12 -week follow-up: (a) whether GM-CSF therapy combined with","confidence":0.9541015625,"confidence_rate":0.9995690364368376},{"cnt":[[120,1697],[1979,1697],[1979,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1859,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"32fcb3ae10b641a4b38b4d680c04168e","type":"text","conversion_output":true,"text":"supervised treadmill exercise (Group A) significantly improves six-minute walk performance compared to GM-","text_display":" supervised treadmill exercise (Group A) significantly improves six-minute walk performance compared to GM","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[1897,1745],[1897,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1778,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3ff66af1b6f435991ab808506e2b8f4","type":"text","conversion_output":true,"text":"CSF therapy alone (Group B), (b) whether GM-CSF therapy combined with supervised treadmill exercise","text_display":"CSF therapy alone (Group B), (b) whether GM-CSF therapy combined with supervised treadmill exercise","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1979,1788],[1979,1835],[120,1835]],"region":{"top_left_x":120,"top_left_y":1787,"width":1859,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f03324b033af411088c296fbdc8228b6","type":"text","conversion_output":true,"text":"(Group A) significantly improves six-minute walk performance compared to supervised exercise therapy alone","text_display":" (Group A) significantly improves six-minute walk performance compared to supervised exercise therapy alone","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1803,1830],[1803,1878],[120,1878]],"region":{"top_left_x":120,"top_left_y":1830,"width":1683,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a5e6205cad08422c94d30bcd2803f23f","type":"text","conversion_output":true,"text":"(Group C) and (c) whether GM-CSF therapy alone (Group B) significantly improves six-minute walk","text_display":" (Group C) and (c) whether GM-CSF therapy alone (Group B) significantly improves six-minute walk","confidence":1,"confidence_rate":1},{"cnt":[[120,1876],[1912,1876],[1912,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1875,"width":1793,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a67f486815504f51aa668b22ddfdfa91","type":"text","conversion_output":true,"text":"performance compared to placebo (Group D). We will also confirm the previously established association","text_display":" performance compared to placebo (Group D). We will also confirm the previously established association","confidence":1,"confidence_rate":1},{"cnt":[[120,1919],[1983,1919],[1983,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1864,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cfd91661a11410486ced545e38e86c9","type":"text","conversion_output":true,"text":"between supervised treadmill exercise (Group C) and improved six-minute walk performance, compared to no","text_display":" between supervised treadmill exercise (Group C) and improved six-minute walk performance, compared to no","confidence":0.7504844665527344,"confidence_rate":0.9973701034677627},{"cnt":[[120,1964],[556,1964],[556,2013],[120,2013]],"region":{"top_left_x":120,"top_left_y":1963,"width":437,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1c3f1e1b94b447cb0e176703d808a31","type":"text","conversion_output":true,"text":"active therapy (Group D).","text_display":" active therapy (Group D).","confidence":1,"confidence_rate":1},{"cnt":[[120,2050],[1968,2050],[1968,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2049,"width":1848,"height":51},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4cf13e63ccfc47d396e8ca18694aa116","type":"text","conversion_output":true,"text":"The final sample size in the PROPEL Trial, of 210 participants, was lower than the originally intended sample","text_display":"\n\nThe final sample size in the PROPEL Trial, of 210 participants, was lower than the originally intended sample","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[120,2097],[1979,2097],[1979,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2096,"width":1859,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c3d19c397384347bde8a54643dea524","type":"text","conversion_output":true,"text":"size of 240 participants. Prior to analyzing the data, investigators propose to alter the statistical analysis plan.","text_display":" size of 240 participants. Prior to analyzing the data, investigators propose to alter the statistical analysis plan.","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[2002,2140],[2002,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1883,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02f279b1b13343f1bfc0996a71427120","type":"text","conversion_output":true,"text":"The new statistical analysis plan allows us to address our original hypotheses but with greater statistical power,","text_display":" The new statistical analysis plan allows us to address our original hypotheses but with greater statistical power,","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1927,2183],[1927,2230],[120,2230]],"region":{"top_left_x":120,"top_left_y":2182,"width":1808,"height":49},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26529270972d453bb36e5edf6cd8b9da","type":"text","conversion_output":true,"text":"given the slightly lower sample size than originally intended. The revised statistical plan is as follows. The","text_display":" given the slightly lower sample size than originally intended. The revised statistical plan is as follows. The","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[120,2226],[1946,2226],[1946,2275],[120,2275]],"region":{"top_left_x":120,"top_left_y":2225,"width":1827,"height":51},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b9a4e538655485ca3da3e9e9ad49a28","type":"text","conversion_output":true,"text":"significance levels of the four primary comparisons will be determined using the Hochberg's step up method","text_display":" significance levels of the four primary comparisons will be determined using the Hochberg's step up method","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[1962,2271],[1962,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1842,"height":47},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35eba9d5ec6547f08db49289e586d252","type":"text","conversion_output":true,"text":"rather than the conservative Bonferroni correction. Specifically, we will sort the p -values from the smallest to","text_display":" rather than the conservative Bonferroni correction. Specifically, we will sort the p -values from the smallest to","confidence":0.996584415435791,"confidence_rate":0.9999724081952608},{"cnt":[[120,2314],[1972,2314],[1972,2370],[120,2370]],"region":{"top_left_x":120,"top_left_y":2313,"width":1853,"height":57},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0651daf470af4fa784f936e206412a20","type":"text","conversion_output":true,"text":"the biggest as \\(p_{(1)}<p_{(2)}<p_{(3)}<p_{(4)}\\). For the purposes of the analysis plan, the \"hypothesis\" refers to the","text_display":" the biggest as \\(p_{(1)}<p_{(2)}<p_{(3)}<p_{(4)}\\). For the purposes of the analysis plan, the \"hypothesis\" refers to the","confidence":1,"confidence_rate":1},{"cnt":[[120,2368],[1906,2368],[1906,2417],[120,2417]],"region":{"top_left_x":120,"top_left_y":2367,"width":1786,"height":50},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"130298bf55c045f2a54c6e2dd15953c8","type":"text","conversion_output":true,"text":"null hypothesis. Rejecting all four hypotheses indicates that the hypotheses specified in our specific aims","text_display":" null hypothesis. Rejecting all four hypotheses indicates that the hypotheses specified in our specific aims","confidence":1,"confidence_rate":1},{"cnt":[[120,2413],[973,2413],[973,2460],[120,2460]],"region":{"top_left_x":120,"top_left_y":2412,"width":854,"height":48},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa5404a15c1c4e9ca7682ac7590c2f37","type":"text","conversion_output":true,"text":"above are correct. Under this assumption, we will","text_display":" above are correct. Under this assumption, we will","confidence":1,"confidence_rate":1},{"cnt":[[185,2458],[909,2458],[909,2512],[185,2512]],"region":{"top_left_x":184,"top_left_y":2457,"width":725,"height":55},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31fa710a9ca74de99d80b96e27502be3","type":"text","conversion_output":true,"text":"(1) reject all four hypothesis if \\(p_{(4)} \\leq 0.05\\);","text_display":"\n(1) reject all four hypothesis if \\(p_{(4)} \\leq 0.05\\);","confidence":0.990234375,"confidence_rate":0.999836453017794},{"cnt":[[185,2512],[1248,2509],[1248,2565],[185,2567]],"region":{"top_left_x":184,"top_left_y":2509,"width":1065,"height":59},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0da265fcb604f878892277409340ab9","type":"text","conversion_output":true,"text":"(2) otherwise, we will reject hypotheses (1-3), if \\(p_{(3)}<0.05 / 2\\);","text_display":"\n(2) otherwise, we will reject hypotheses (1-3), if \\(p_{(3)}<0.05 / 2\\);","confidence":0.979529129108414,"confidence_rate":0.9997382203046287},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3408a35a7c9e4d94a9906dad1cd2ca06","type":"page_info","conversion_output":false,"text":"15","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-16","page":16,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"831d1f5c9c1844729fdc708d977ac3d6","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,165],[1738,165]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fc7d86bd221d411f881eacadfd5dda73","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[185,202],[1248,202],[1248,260],[185,260]],"region":{"top_left_x":184,"top_left_y":201,"width":1065,"height":59},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f193f992ca94d25a268d0bf5ce00090","type":"text","conversion_output":true,"text":"(3) otherwise, we will reject hypotheses (1-2), if \\(p_{(2)}<0.05 / 3\\);","text_display":"\n(3) otherwise, we will reject hypotheses (1-2), if \\(p_{(2)}<0.05 / 3\\);","confidence":0.99951171875,"confidence_rate":0.999993817734324},{"cnt":[[185,258],[1257,258],[1257,316],[185,316]],"region":{"top_left_x":184,"top_left_y":257,"width":1073,"height":59},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd5ae920eb4b4919be99ca25fa82931c","type":"text","conversion_output":true,"text":"(4) otherwise, we will reject the hypothesis (1), if \\(p_{(1)}<0.05 / 4\\)","text_display":"\n(4) otherwise, we will reject the hypothesis (1), if \\(p_{(1)}<0.05 / 4\\)","confidence":0.9887843085452914,"confidence_rate":0.999849623819708},{"cnt":[[120,357],[1923,357],[1923,408],[120,408]],"region":{"top_left_x":120,"top_left_y":356,"width":1803,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76ec1226b8c4400b9a351c9ecb1bcbe4","type":"text","conversion_output":true,"text":"The Hochberg's step up method also controls the family-wise type one error and is more powerful than the","text_display":"\n\nThe Hochberg's step up method also controls the family-wise type one error and is more powerful than the","confidence":1,"confidence_rate":1},{"cnt":[[120,404],[513,404],[513,453],[120,453]],"region":{"top_left_x":120,"top_left_y":403,"width":394,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26deeba9cd4b47fa8b2ebd00ff931bc8","type":"text","conversion_output":true,"text":"Bonferroni adjustment.","text_display":" Bonferroni adjustment.","confidence":1,"confidence_rate":1},{"cnt":[[120,490],[1895,490],[1895,539],[120,539]],"region":{"top_left_x":120,"top_left_y":489,"width":1775,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2c96fcf50e44879bb8fb9a7fa2a5dc6","type":"text","conversion_output":true,"text":"C21. Statistical Analyses Methods. Change in six minute walking distance at 12 -week follow-up is our","text_display":"\n\nC21. Statistical Analyses Methods. Change in six minute walking distance at 12 -week follow-up is our","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[120,535],[1936,535],[1936,582],[120,582]],"region":{"top_left_x":120,"top_left_y":534,"width":1816,"height":49},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"267da96eb2d849dd9e6018856bbaa10d","type":"text","conversion_output":true,"text":"primary outcome. Changes in brachial artery FMD, maximal treadmill walking time, and CD34+ cells at 12-","text_display":" primary outcome. Changes in brachial artery FMD, maximal treadmill walking time, and CD34+ cells at 12","confidence":0.94580078125,"confidence_rate":0.9994841763906129},{"cnt":[[120,580],[1979,580],[1979,627],[120,627]],"region":{"top_left_x":120,"top_left_y":580,"width":1859,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f6e31b25da14b6fa3a504fbab0c974c","type":"text","conversion_output":true,"text":"week follow-up are secondary outcomes. The distributions of each outcome will be examined and appropriate","text_display":"week follow-up are secondary outcomes. The distributions of each outcome will be examined and appropriate","confidence":1,"confidence_rate":1},{"cnt":[[120,623],[1957,623],[1957,672],[120,672]],"region":{"top_left_x":120,"top_left_y":623,"width":1838,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b223472d45714ec8b0c2bd7820cef2b3","type":"text","conversion_output":true,"text":"transformations will be performed if necessary. Prior to the analyses, baseline characteristics (i.e., age, sex,","text_display":" transformations will be performed if necessary. Prior to the analyses, baseline characteristics (i.e., age, sex,","confidence":1,"confidence_rate":1},{"cnt":[[120,666],[1970,666],[1970,715],[120,715]],"region":{"top_left_x":120,"top_left_y":666,"width":1851,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c791ffc003c4e40aff04d6824d0711c","type":"text","conversion_output":true,"text":"race, baseline six-minute walk, \\(ABI , CD 34+\\) cells, and other relevant variables) will be compared between the","text_display":" race, baseline six-minute walk, \\(ABI , CD 34+\\) cells, and other relevant variables) will be compared between the","confidence":0.41976542124262495,"confidence_rate":0.9928516286778427},{"cnt":[[120,709],[1968,709],[1968,758],[120,758]],"region":{"top_left_x":120,"top_left_y":708,"width":1848,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"254e19bda30b4f88bd8a50984abd5fa7","type":"text","conversion_output":true,"text":"four groups, using a F-test or Chi-Square test to ensure that baseline characteristics are balanced across the","text_display":" four groups, using a F-test or Chi-Square test to ensure that baseline characteristics are balanced across the","confidence":1,"confidence_rate":1},{"cnt":[[120,752],[1936,752],[1936,804],[120,804]],"region":{"top_left_x":120,"top_left_y":751,"width":1816,"height":53},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0043e39ad1946e29139316d97d81919","type":"text","conversion_output":true,"text":"four groups. Any variables that are significantly different between groups will be adjusted for as covariates.","text_display":" four groups. Any variables that are significantly different between groups will be adjusted for as covariates.","confidence":0.99169921875,"confidence_rate":0.9999275206738922},{"cnt":[[120,842],[1983,842],[1983,889],[120,889]],"region":{"top_left_x":120,"top_left_y":842,"width":1864,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"324aebe109f648b8b7ff9b0cb37d5b75","type":"text","conversion_output":true,"text":"For our Primary Aim, we will compare changes in six minute walk distance from baseline to 12 -week follow-up","text_display":"\n\nFor our Primary Aim, we will compare changes in six minute walk distance from baseline to 12 -week follow-up","confidence":1,"confidence_rate":1},{"cnt":[[120,885],[1983,885],[1983,935],[120,935]],"region":{"top_left_x":120,"top_left_y":885,"width":1864,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8060b94a62f94b17a578dbdd63aa9414","type":"text","conversion_output":true,"text":"between Groups A and B, between Groups A and C, between Groups B and D, and between Groups C and D","text_display":" between Groups A and B, between Groups A and C, between Groups B and D, and between Groups C and D","confidence":0.9863914117663446,"confidence_rate":0.9998669793935214},{"cnt":[[120,930],[1846,930],[1846,978],[120,978]],"region":{"top_left_x":120,"top_left_y":930,"width":1726,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7b543681a6e2481393642a17c3721e7e","type":"text","conversion_output":true,"text":"using a two-sample t-test. Analysis of covariance will be used to adjust for baseline characteristics as","text_display":" using a two-sample t-test. Analysis of covariance will be used to adjust for baseline characteristics as","confidence":1,"confidence_rate":1},{"cnt":[[120,975],[1934,975],[1934,1023],[120,1023]],"region":{"top_left_x":120,"top_left_y":975,"width":1814,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ebbb477fd8794a85ba52db5f2ecaef42","type":"text","conversion_output":true,"text":"necessary. For our Secondary Aim, we will compare changes in brachial artery FMD and maximal treadmill","text_display":" necessary. For our Secondary Aim, we will compare changes in brachial artery FMD and maximal treadmill","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[120,1018],[1914,1018],[1914,1068],[120,1068]],"region":{"top_left_x":120,"top_left_y":1018,"width":1795,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c68b33870512407dbe96a08e23171d19","type":"text","conversion_output":true,"text":"walking time from baseline to 12 -week follow-up between Groups A and B , between Groups A and C , and","text_display":" walking time from baseline to 12 -week follow-up between Groups A and B , between Groups A and C , and","confidence":0.8129518032073975,"confidence_rate":0.998455794604748},{"cnt":[[120,1061],[1962,1061],[1962,1111],[120,1111]],"region":{"top_left_x":120,"top_left_y":1061,"width":1842,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9c7534bb79c4c21872956d40e5dc696","type":"text","conversion_output":true,"text":"between Groups B and D. We will also determine whether participants in Group C have greater increases in","text_display":" between Groups B and D. We will also determine whether participants in Group C have greater increases in","confidence":0.8785076346248388,"confidence_rate":0.9988123509436748},{"cnt":[[120,1104],[1979,1104],[1979,1154],[120,1154]],"region":{"top_left_x":120,"top_left_y":1104,"width":1859,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7950191ca9b24f46ba937466e50f9627","type":"text","conversion_output":true,"text":"CD34+ cells at 12-week follow-up, compared to Group D. The two-sample t-test or analysis of covariance will","text_display":" CD34+ cells at 12-week follow-up, compared to Group D. The two-sample t-test or analysis of covariance will","confidence":0.5490300594829023,"confidence_rate":0.9946607148723506},{"cnt":[[120,1147],[2000,1147],[2000,1197],[120,1197]],"region":{"top_left_x":120,"top_left_y":1147,"width":1881,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16a7e502b5b74ada9ec80425b519a5f3","type":"text","conversion_output":true,"text":"be used for these comparisons. Efficiency augmentation methods for estimating the treatment effects using the","text_display":" be used for these comparisons. Efficiency augmentation methods for estimating the treatment effects using the","confidence":1,"confidence_rate":1},{"cnt":[[120,1192],[1919,1192],[1919,1242],[120,1242]],"region":{"top_left_x":120,"top_left_y":1192,"width":1799,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52e6d4453f0d4e14a22cb43a1ff1232e","type":"text","conversion_output":true,"text":"distribution of baseline characteristics will be employed (96). The \\(95 \\%\\) confidence interval of the treatment","text_display":" distribution of baseline characteristics will be employed (96). The \\(95 \\%\\) confidence interval of the treatment","confidence":0.5060863494873047,"confidence_rate":0.9941460980302722},{"cnt":[[120,1238],[1983,1238],[1983,1285],[120,1285]],"region":{"top_left_x":120,"top_left_y":1237,"width":1864,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ba1590113eb64ef295519582ee887d2f","type":"text","conversion_output":true,"text":"effects will be constructed. Because the primary aim of the study is to demonstrate the superiority of Group A","text_display":" effects will be constructed. Because the primary aim of the study is to demonstrate the superiority of Group A","confidence":1,"confidence_rate":1},{"cnt":[[120,1280],[1996,1280],[1996,1330],[120,1330]],"region":{"top_left_x":120,"top_left_y":1280,"width":1876,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a978e8f17dd4817ac68da665438c082","type":"text","conversion_output":true,"text":"(GM-CSF + supervised exercise) as compared to Group B (GM-CSF alone) and Group C (supervised exercise","text_display":" (GM-CSF + supervised exercise) as compared to Group B (GM-CSF alone) and Group C (supervised exercise","confidence":0.98974609375,"confidence_rate":0.9999027703902427},{"cnt":[[120,1326],[1835,1326],[1835,1373],[120,1373]],"region":{"top_left_x":120,"top_left_y":1325,"width":1715,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6319d85e71c46bd98c372f6cb06def1","type":"text","conversion_output":true,"text":"alone), the commonly used two-way analysis of variance will be used only in supplementary analysis.","text_display":" alone), the commonly used two-way analysis of variance will be used only in supplementary analysis.","confidence":1,"confidence_rate":1},{"cnt":[[120,1371],[1858,1371],[1858,1418],[120,1418]],"region":{"top_left_x":120,"top_left_y":1370,"width":1739,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f9cf96f9a8b747d0bbc44636951bdf3d","type":"text","conversion_output":true,"text":"Specifically, for the outcomes of interest in our primary and secondary aims, we will test the interaction","text_display":" Specifically, for the outcomes of interest in our primary and secondary aims, we will test the interaction","confidence":1,"confidence_rate":1},{"cnt":[[120,1414],[1966,1414],[1966,1463],[120,1463]],"region":{"top_left_x":120,"top_left_y":1413,"width":1846,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dcef36c8b9f494f982833c3a843940c","type":"text","conversion_output":true,"text":"between GM-CSF and supervised exercise with two-way ANOVA. In the absence of an interaction (i.e, the p","text_display":" between GM-CSF and supervised exercise with two-way ANOVA. In the absence of an interaction (i.e, the p","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[120,1457],[1863,1457],[1863,1506],[120,1506]],"region":{"top_left_x":120,"top_left_y":1456,"width":1743,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"602a962d1632464b9246abdb9d4b3e69","type":"text","conversion_output":true,"text":"value for the interaction term exceeds 0.25 ), we will further estimate the additive effect of GM-CSF and","text_display":" value for the interaction term exceeds 0.25 ), we will further estimate the additive effect of GM-CSF and","confidence":1,"confidence_rate":1},{"cnt":[[120,1502],[2000,1502],[2000,1549],[120,1549]],"region":{"top_left_x":120,"top_left_y":1501,"width":1881,"height":49},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd28ade46d6b464080f36bb7712767e9","type":"text","conversion_output":true,"text":"supervised exercise simultaneously in all 240 participants. Here, the existence of model-based additive effects","text_display":" supervised exercise simultaneously in all 240 participants. Here, the existence of model-based additive effects","confidence":1,"confidence_rate":1},{"cnt":[[120,1543],[1824,1543],[1824,1592],[120,1592]],"region":{"top_left_x":120,"top_left_y":1542,"width":1705,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c9fc88f802f4a288a589a37224d5e69","type":"text","conversion_output":true,"text":"for GM-CSF and exercise is much stronger than the targeted superiority of the combined treatments.","text_display":" for GM-CSF and exercise is much stronger than the targeted superiority of the combined treatments.","confidence":0.9990236759185791,"confidence_rate":0.9999905165401506},{"cnt":[[120,1633],[1914,1633],[1914,1680],[120,1680]],"region":{"top_left_x":120,"top_left_y":1632,"width":1795,"height":49},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7dfa69ddfeb40dd9fdf339300aeca60","type":"text","conversion_output":true,"text":"For our Exploratory Aims, we will use linear mixed effects regression analyses to compare changes in six-","text_display":"\n\nFor our Exploratory Aims, we will use linear mixed effects regression analyses to compare changes in six","confidence":1,"confidence_rate":1},{"cnt":[[120,1676],[1979,1676],[1979,1725],[120,1725]],"region":{"top_left_x":120,"top_left_y":1675,"width":1859,"height":51},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06c81c689e204ab685545b2a6cc8cd7b","type":"text","conversion_output":true,"text":"minute walk performance, maximal treadmill walking time, and brachial artery FMD between baseline and six-","text_display":"minute walk performance, maximal treadmill walking time, and brachial artery FMD between baseline and six","confidence":1,"confidence_rate":1},{"cnt":[[120,1721],[1919,1721],[1919,1768],[120,1768]],"region":{"top_left_x":120,"top_left_y":1720,"width":1799,"height":49},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d4a8c89490b4536a5c05f9a5274f49e","type":"text","conversion_output":true,"text":"week follow-up and between baseline and six month follow-up between Groups A and B, Groups A and C,","text_display":"week follow-up and between baseline and six month follow-up between Groups A and B, Groups A and C,","confidence":1,"confidence_rate":1},{"cnt":[[120,1764],[1893,1764],[1893,1811],[120,1811]],"region":{"top_left_x":120,"top_left_y":1763,"width":1773,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d202e17de9c94c27b08e6a0ab74c58a2","type":"text","conversion_output":true,"text":"Groups B and D, and Groups C and D. We will use linear mixed effects regression analyses to compare","text_display":" Groups B and D, and Groups C and D. We will use linear mixed effects regression analyses to compare","confidence":1,"confidence_rate":1},{"cnt":[[120,1809],[1974,1809],[1974,1858],[120,1858]],"region":{"top_left_x":120,"top_left_y":1808,"width":1855,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2b2a37c3f8648c3a46053b601103119","type":"text","conversion_output":true,"text":"changes in progenitor cell measures between baseline and six-week follow-up and between baseline and six-","text_display":" changes in progenitor cell measures between baseline and six-week follow-up and between baseline and six","confidence":1,"confidence_rate":1},{"cnt":[[120,1852],[1949,1852],[1949,1901],[120,1901]],"region":{"top_left_x":120,"top_left_y":1851,"width":1829,"height":51},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"689351993afe4c2ab1220603ec99aa74","type":"text","conversion_output":true,"text":"month follow-up between Groups C and D. Outcomes measured at baseline and each follow-up visit will be","text_display":"month follow-up between Groups C and D. Outcomes measured at baseline and each follow-up visit will be","confidence":0.9887919342145324,"confidence_rate":0.9998946658334771},{"cnt":[[120,1897],[1876,1897],[1876,1944],[120,1944]],"region":{"top_left_x":120,"top_left_y":1897,"width":1756,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e23e7e288f646a797736724cba69437","type":"text","conversion_output":true,"text":"longitudinal response variables in the regression model. The regression coefficients for the interactions","text_display":" longitudinal response variables in the regression model. The regression coefficients for the interactions","confidence":1,"confidence_rate":1},{"cnt":[[120,1938],[1966,1938],[1966,1987],[120,1987]],"region":{"top_left_x":120,"top_left_y":1937,"width":1846,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4266ed7d410d404baecd30618815e79f","type":"text","conversion_output":true,"text":"between group indicators and visit time are parameters of interest. The subject specific random intercept will","text_display":" between group indicators and visit time are parameters of interest. The subject specific random intercept will","confidence":1,"confidence_rate":1},{"cnt":[[120,1985],[1996,1985],[1996,2032],[120,2032]],"region":{"top_left_x":120,"top_left_y":1985,"width":1876,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b091015e6efd4bd5930d634f793c5a03","type":"text","conversion_output":true,"text":"be used to incorporate the within subject correlations. For our Exploratory Aim \\#4, we will employ linear mixed","text_display":" be used to incorporate the within subject correlations. For our Exploratory Aim \\#4, we will employ linear mixed","confidence":1,"confidence_rate":1},{"cnt":[[120,2028],[1910,2028],[1910,2075],[120,2075]],"region":{"top_left_x":120,"top_left_y":2028,"width":1790,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d73e6e25fa4a4985859e303e29dbe6dd","type":"text","conversion_output":true,"text":"regression analysis to evaluate the association between changes in CD34+ cells and other progenitor cell","text_display":" regression analysis to evaluate the association between changes in CD34+ cells and other progenitor cell","confidence":1,"confidence_rate":1},{"cnt":[[120,2071],[1979,2071],[1979,2121],[120,2121]],"region":{"top_left_x":120,"top_left_y":2071,"width":1859,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1aec60dac4f746a2a0a8484dc8f12de6","type":"text","conversion_output":true,"text":"measures from baseline to two-week follow-up with changes in six-minute walk distance, brachial artery FMD,","text_display":" measures from baseline to two-week follow-up with changes in six-minute walk distance, brachial artery FMD,","confidence":1,"confidence_rate":1},{"cnt":[[120,2116],[1921,2116],[1921,2163],[120,2163]],"region":{"top_left_x":120,"top_left_y":2116,"width":1801,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"768e6ff45808478aa694172503a33f44","type":"text","conversion_output":true,"text":"and maximal treadmill walking time between baseline and six-week, twelve-week, and six-month follow-up","text_display":" and maximal treadmill walking time between baseline and six-week, twelve-week, and six-month follow-up","confidence":1,"confidence_rate":1},{"cnt":[[120,2159],[1944,2159],[1944,2206],[120,2206]],"region":{"top_left_x":120,"top_left_y":2159,"width":1825,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da5a958d29fe4417a71c665c371e083a","type":"text","conversion_output":true,"text":"visits. The responses are longitudinally measured outcomes of change between baseline and the six-week,","text_display":" visits. The responses are longitudinally measured outcomes of change between baseline and the six-week,","confidence":1,"confidence_rate":1},{"cnt":[[120,2204],[1970,2204],[1970,2252],[120,2252]],"region":{"top_left_x":120,"top_left_y":2204,"width":1851,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"989089e060734be58666888c019552d3","type":"text","conversion_output":true,"text":"twelve-week, and six-month visits, respectively. The independent variables of interest are changes in CD34+","text_display":" twelve-week, and six-month visits, respectively. The independent variables of interest are changes in CD34+","confidence":1,"confidence_rate":1},{"cnt":[[120,2247],[1938,2247],[1938,2297],[120,2297]],"region":{"top_left_x":120,"top_left_y":2247,"width":1818,"height":50},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddb21fc901d24225b0b6cc11dd5e8ee3","type":"text","conversion_output":true,"text":"cells and other progenitor cell measures from baseline to two-week follow-up. We will employ similar linear","text_display":" cells and other progenitor cell measures from baseline to two-week follow-up. We will employ similar linear","confidence":1,"confidence_rate":1},{"cnt":[[120,2292],[1989,2292],[1989,2340],[120,2340]],"region":{"top_left_x":120,"top_left_y":2292,"width":1870,"height":48},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6b6758da6284a93b34e05d4e1d34187","type":"text","conversion_output":true,"text":"mixed regression analysis to evaluate associations between changes in progenitor cells between baseline and","text_display":" mixed regression analysis to evaluate associations between changes in progenitor cells between baseline and","confidence":1,"confidence_rate":1},{"cnt":[[120,2333],[1934,2333],[1934,2383],[120,2383]],"region":{"top_left_x":120,"top_left_y":2333,"width":1814,"height":50},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6ab88602efa4c64989ebe4d37542d6d","type":"text","conversion_output":true,"text":"six-week, 12 -week, and six-month follow-up with changes in six-minute walk distance, brachial artery FMD,","text_display":" six-week, 12 -week, and six-month follow-up with changes in six-minute walk distance, brachial artery FMD,","confidence":0.54638671875,"confidence_rate":0.9947120283695875},{"cnt":[[120,2378],[1936,2378],[1936,2428],[120,2428]],"region":{"top_left_x":120,"top_left_y":2378,"width":1816,"height":50},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd56aea0e1114f7492c30eb8b884cdb7","type":"text","conversion_output":true,"text":"and maximal treadmill walking time during the corresponding time period. The responses are longitudinally","text_display":" and maximal treadmill walking time during the corresponding time period. The responses are longitudinally","confidence":1,"confidence_rate":1},{"cnt":[[120,2423],[1858,2423],[1858,2471],[120,2471]],"region":{"top_left_x":120,"top_left_y":2423,"width":1739,"height":48},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56544c2bf1ab45f398b22b6c4ad1225c","type":"text","conversion_output":true,"text":"measured outcomes of change between baseline and the six-week, twelve-week, and six-month visits,","text_display":" measured outcomes of change between baseline and the six-week, twelve-week, and six-month visits,","confidence":1,"confidence_rate":1},{"cnt":[[120,2466],[1966,2466],[1966,2516],[120,2516]],"region":{"top_left_x":120,"top_left_y":2466,"width":1846,"height":50},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40eeb709b2bc4f29814f16ee6b4528c2","type":"text","conversion_output":true,"text":"respectively. Independent variables of interest are changes in progenitor cells from baseline to six-week, 12-","text_display":" respectively. Independent variables of interest are changes in progenitor cells from baseline to six-week, 12","confidence":0.822265625,"confidence_rate":0.9982997792647395},{"cnt":[[120,2512],[1998,2512],[1998,2563],[120,2563]],"region":{"top_left_x":120,"top_left_y":2511,"width":1879,"height":53},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e2b38f2e64147aa924c6984c19a30f5","type":"text","conversion_output":true,"text":"week, and six-month follow-up. Finally, we will perform regression analyses among participants randomized to","text_display":"week, and six-month follow-up. Finally, we will perform regression analyses among participants randomized to","confidence":1,"confidence_rate":1},{"cnt":[[1038,2582],[1091,2582],[1091,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":55,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8096c82f5d9340e09ca5d44a5676e1c8","type":"page_info","conversion_output":false,"text":"16","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-17","page":17,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e1b6edc7fca14db4a9dd16daa7f4939a","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,165],[1740,165]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"26bbef654b4b47f8ab26c2b382719fc0","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1944,206],[1944,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1825,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c7d95fd18d54db1be0cb136bb54c430","type":"text","conversion_output":true,"text":"the exercise group to determine whether the degree of increase in lactate levels during exercise sessions is","text_display":"\nthe exercise group to determine whether the degree of increase in lactate levels during exercise sessions is","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[1102,249],[1102,299],[120,299]],"region":{"top_left_x":120,"top_left_y":249,"width":983,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49bd654a505a40049e5ee6a66ab8b2b2","type":"text","conversion_output":true,"text":"associated with the degree of increase in progenitor cells.","text_display":" associated with the degree of increase in progenitor cells.","confidence":1,"confidence_rate":1},{"cnt":[[120,337],[1944,337],[1944,385],[120,385]],"region":{"top_left_x":120,"top_left_y":337,"width":1825,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"885b109b8e2640daa645a6d66340fa65","type":"text","conversion_output":true,"text":"C22. Intention to Treat. In all comparisons, we will employ the intention-to-treat principle. Participants will","text_display":"\n\nC22. Intention to Treat. In all comparisons, we will employ the intention-to-treat principle. Participants will","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[1884,382],[1884,432],[120,432]],"region":{"top_left_x":120,"top_left_y":382,"width":1765,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c476a6f99c049828ac8ed8e9dfd4aab","type":"text","conversion_output":true,"text":"remain in their originally assigned groups for analyses, regardless of adherence to their assigned group.","text_display":" remain in their originally assigned groups for analyses, regardless of adherence to their assigned group.","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1886,425],[1886,475],[120,475]],"region":{"top_left_x":120,"top_left_y":425,"width":1767,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e9c18d1896c45dbb73557033d57a816","type":"text","conversion_output":true,"text":"Based on our experience in our SILC clinical trial, the drop-out rate is expected to be \\(<10 \\%\\) at six-month","text_display":" Based on our experience in our SILC clinical trial, the drop-out rate is expected to be \\(<10 \\%\\) at six-month","confidence":1,"confidence_rate":1},{"cnt":[[120,468],[1992,468],[1992,518],[120,518]],"region":{"top_left_x":120,"top_left_y":468,"width":1872,"height":50},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a40ec094fdd48b68e594be59ebd0773","type":"text","conversion_output":true,"text":"follow-up. Therefore, complete case analysis coupled with reasonable sensitivity analysis should be adequate","text_display":" follow-up. Therefore, complete case analysis coupled with reasonable sensitivity analysis should be adequate","confidence":1,"confidence_rate":1},{"cnt":[[120,511],[1841,511],[1841,561],[120,561]],"region":{"top_left_x":120,"top_left_y":511,"width":1722,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85a8285d623e45d793050fe257696868","type":"text","conversion_output":true,"text":"to handle the problem of missing data. If the drop-out rate exceeds five percent, we will employ more","text_display":" to handle the problem of missing data. If the drop-out rate exceeds five percent, we will employ more","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1953,559],[1953,606],[120,606]],"region":{"top_left_x":120,"top_left_y":558,"width":1833,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea0e42169c45401db8fad86a965a9719","type":"text","conversion_output":true,"text":"sophisticated statistical methods such as multiple imputation and the pattern mixture approach to correct for","text_display":" sophisticated statistical methods such as multiple imputation and the pattern mixture approach to correct for","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1992,602],[1992,649],[120,649]],"region":{"top_left_x":120,"top_left_y":601,"width":1872,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a23064cb382842efa3c1c560fd9d57b8","type":"text","conversion_output":true,"text":"the potential bias of estimates from simple complete-case analysis due to informative missing data. The study","text_display":" the potential bias of estimates from simple complete-case analysis due to informative missing data. The study","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1940,645],[1940,694],[120,694]],"region":{"top_left_x":120,"top_left_y":644,"width":1821,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"222cf0789df6421fb35d7c181a8c2b75","type":"text","conversion_output":true,"text":"team has substantial experience employing these methods in prior studies \\((44,97,98)\\). We will use the type","text_display":" team has substantial experience employing these methods in prior studies \\((44,97,98)\\). We will use the type","confidence":0.98583984375,"confidence_rate":0.9998749081066911},{"cnt":[[120,690],[1154,690],[1154,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1034,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c91316ea77aa442e97c640b711f8fceb","type":"text","conversion_output":true,"text":"one error value of 0.0125 to cope with multiple comparisons.","text_display":" one error value of 0.0125 to cope with multiple comparisons.","confidence":1,"confidence_rate":1},{"cnt":[[120,776],[2004,776],[2004,827],[120,827]],"region":{"top_left_x":120,"top_left_y":775,"width":1885,"height":53},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24debdd622fd45e483b3d8f03ab1953c","type":"text","conversion_output":true,"text":"C23. Follow-up window. Follow-up testing will be completed within one week before or after the target follow-","text_display":"\n\nC23. Follow-up window. Follow-up testing will be completed within one week before or after the target follow","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1985,821],[1985,870],[120,870]],"region":{"top_left_x":120,"top_left_y":820,"width":1866,"height":51},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e9ea65993ee4e6a88e9f2ea0263611b","type":"text","conversion_output":true,"text":"up date, at the 2 -week, 6 -week, 12 -week, and 26 -week follow-up time points after randomization. However, if","text_display":"up date, at the 2 -week, 6 -week, 12 -week, and 26 -week follow-up time points after randomization. However, if","confidence":1,"confidence_rate":1},{"cnt":[[120,864],[1998,864],[1998,913],[120,913]],"region":{"top_left_x":120,"top_left_y":863,"width":1879,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cd51f400a2142e3b40453061a31d4e1","type":"text","conversion_output":true,"text":"the follow-up visit cannot be performed within the one week before or after the due date for each follow-up visit","text_display":" the follow-up visit cannot be performed within the one week before or after the due date for each follow-up visit","confidence":1,"confidence_rate":1},{"cnt":[[120,907],[1944,907],[1944,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1825,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0534a19c0c442d191d91219e3620651","type":"text","conversion_output":true,"text":"(e.g. if a participant is sick and unable to return to the center for testing within the follow-up window), we will","text_display":" (e.g. if a participant is sick and unable to return to the center for testing within the follow-up window), we will","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1886,954],[1886,1001],[120,1001]],"region":{"top_left_x":120,"top_left_y":953,"width":1767,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"47f9b9a38a4a4b82a5ecbab4d165a263","type":"text","conversion_output":true,"text":"obtain follow-up measures at any point up until the next scheduled follow-up test. For example, if we are","text_display":" obtain follow-up measures at any point up until the next scheduled follow-up test. For example, if we are","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1944,997],[1944,1044],[120,1044]],"region":{"top_left_x":120,"top_left_y":996,"width":1825,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7cde5e32e41b499ca6ad2da61ca7335a","type":"text","conversion_output":true,"text":"unable to obtain the 12 -week follow-up measures within the window, we will attempt to obtain the measures","text_display":" unable to obtain the 12 -week follow-up measures within the window, we will attempt to obtain the measures","confidence":0.99853515625,"confidence_rate":0.9999871411556362},{"cnt":[[120,1040],[978,1040],[978,1089],[120,1089]],"region":{"top_left_x":120,"top_left_y":1039,"width":858,"height":51},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eff5ada310724fd88fb20abfb0733a95","type":"text","conversion_output":true,"text":"until the 26 -week follow-up testing window begins.","text_display":" until the 26 -week follow-up testing window begins.","confidence":0.9794921875,"confidence_rate":0.9996488579760249},{"cnt":[[116,1126],[561,1126],[561,1175],[116,1175]],"region":{"top_left_x":116,"top_left_y":1125,"width":445,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9981c9ba04764657b4d9ea499e5000e1","type":"section_header","conversion_output":false,"children_ids":["fb0c1834c51247f1891e9233e4d906a6"],"text":"","text_display":""},{"cnt":[[120,1130],[554,1130],[554,1171],[120,1171]],"region":{"top_left_x":120,"top_left_y":1130,"width":435,"height":41},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb0c1834c51247f1891e9233e4d906a6","type":"text","conversion_output":true,"parent_id":"9981c9ba04764657b4d9ea499e5000e1","text":"D. HUMAN SUBJECTS.","text_display":"\n\n\\section*{D. HUMAN SUBJECTS.}","confidence":1,"confidence_rate":1},{"cnt":[[120,1171],[1931,1171],[1931,1222],[120,1222]],"region":{"top_left_x":120,"top_left_y":1170,"width":1812,"height":53},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0078cb72544d42368223dc7e70e56049","type":"text","conversion_output":true,"text":"D1. Risks to the subjects. As described in section C. 2 above, subjects will be randomized to one of four","text_display":"\n\nD1. Risks to the subjects. As described in section C. 2 above, subjects will be randomized to one of four","confidence":0.9809989691711962,"confidence_rate":0.9998302456469699},{"cnt":[[120,1216],[1863,1216],[1863,1265],[120,1265]],"region":{"top_left_x":120,"top_left_y":1216,"width":1743,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"50afff4d2a28482ea1b1c01e52766b83","type":"text","conversion_output":true,"text":"groups: Group A: GM-CSF and supervised treadmill exercise; Group B: GM-CSF and attention control","text_display":" groups: Group A: GM-CSF and supervised treadmill exercise; Group B: GM-CSF and attention control","confidence":1,"confidence_rate":1},{"cnt":[[120,1259],[1919,1259],[1919,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1258,"width":1799,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2b587755c8344bf9f7a46a80653d399","type":"text","conversion_output":true,"text":"condition; Group C: placebo injections and supervised treadmill exercise; Group D: placebo injections and","text_display":" condition; Group C: placebo injections and supervised treadmill exercise; Group D: placebo injections and","confidence":0.9936621134412462,"confidence_rate":0.9999422011592447},{"cnt":[[120,1302],[1998,1302],[1998,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1879,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"514bfa0db846414282cc90413f1daf7c","type":"text","conversion_output":true,"text":"attention control condition (see Figure 2). Study participation will last for 6 months. Participants receiving GM-","text_display":" attention control condition (see Figure 2). Study participation will last for 6 months. Participants receiving GM","confidence":1,"confidence_rate":1},{"cnt":[[120,1347],[1803,1347],[1803,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1347,"width":1683,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e9275a5689a5476491425370a022e54f","type":"text","conversion_output":true,"text":"CSF will receive a GM-CSF injection three times weekly for the first two weeks after randomization.","text_display":"CSF will receive a GM-CSF injection three times weekly for the first two weeks after randomization.","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1914,1392],[1914,1442],[120,1442]],"region":{"top_left_x":120,"top_left_y":1392,"width":1795,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d774e220e8114ec6bee8cd6cd7bd6f9d","type":"text","conversion_output":true,"text":"Participants receiving placebo injections (rather than GM-CSF) will receive a placebo injection three times","text_display":" Participants receiving placebo injections (rather than GM-CSF) will receive a placebo injection three times","confidence":1,"confidence_rate":1},{"cnt":[[120,1435],[1895,1435],[1895,1485],[120,1485]],"region":{"top_left_x":120,"top_left_y":1435,"width":1775,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0fe38db7e2ce4892bcd6e4250fabd52e","type":"text","conversion_output":true,"text":"weekly for two weeks. Participants randomized to supervised treadmill exercise will exercise three times","text_display":" weekly for two weeks. Participants randomized to supervised treadmill exercise will exercise three times","confidence":1,"confidence_rate":1},{"cnt":[[120,1480],[1910,1480],[1910,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1790,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1883569d4d2d4f8886287c73fb5b7697","type":"text","conversion_output":true,"text":"weekly for six months with a trainer at the study exercise facility. Participants randomized to the attention","text_display":" weekly for six months with a trainer at the study exercise facility. Participants randomized to the attention","confidence":1,"confidence_rate":1},{"cnt":[[120,1525],[1981,1525],[1981,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":1861,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afb70a86d7fb4ef5935762e34dcb6ea6","type":"text","conversion_output":true,"text":"control group will attend weekly educational sessions at Northwestern University Feinberg School of Medicine","text_display":" control group will attend weekly educational sessions at Northwestern University Feinberg School of Medicine","confidence":1,"confidence_rate":1},{"cnt":[[120,1568],[1985,1568],[1985,1618],[120,1618]],"region":{"top_left_x":120,"top_left_y":1568,"width":1866,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"867eae8063a64c7c90d8b3a5f77a8197","type":"text","conversion_output":true,"text":"for six months. We will randomize a total of 267 participants with peripheral arterial disease (PAD). Based on","text_display":" for six months. We will randomize a total of 267 participants with peripheral arterial disease (PAD). Based on","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[1972,1611],[1972,1661],[120,1661]],"region":{"top_left_x":120,"top_left_y":1611,"width":1853,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3602886a7c204e8fa8e7834705935959","type":"text","conversion_output":true,"text":"our prior work, we expect that 240 participants will complete the study. Based on our previous work involving","text_display":" our prior work, we expect that 240 participants will complete the study. Based on our previous work involving","confidence":1,"confidence_rate":1},{"cnt":[[120,1654],[1972,1654],[1972,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1654,"width":1853,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e82121b5185641a8afd3f868bfda87d3","type":"text","conversion_output":true,"text":"participants with PAD, we anticipate that the average age will be approximately 70 years, that at least \\(33 \\%\\) of","text_display":" participants with PAD, we anticipate that the average age will be approximately 70 years, that at least \\(33 \\%\\) of","confidence":1,"confidence_rate":1},{"cnt":[[120,1697],[1869,1697],[1869,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1750,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e224433711a4b189d69cf9d9f166a39","type":"text","conversion_output":true,"text":"participants will be minorities, and that approximately \\(50 \\%\\) will be women. For example, in our recently","text_display":" participants will be minorities, and that approximately \\(50 \\%\\) will be women. For example, in our recently","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[1936,1742],[1936,1792],[120,1794]],"region":{"top_left_x":120,"top_left_y":1742,"width":1816,"height":52},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b73fdc68a44445ee9c059956ffce865b","type":"text","conversion_output":true,"text":"completed SILC randomized controlled clinical trial of exercise in patients with PAD (see section A7 above)","text_display":" completed SILC randomized controlled clinical trial of exercise in patients with PAD (see section A7 above)","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1951,1788],[1951,1835],[120,1835]],"region":{"top_left_x":120,"top_left_y":1787,"width":1831,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddc3f0c7b7934d3b83d3b52aeb1d9668","type":"text","conversion_output":true,"text":"(44), participants were average age \\(70.6 \\pm 10.3\\) and the average ABI was \\(0.61 \\pm 0.17\\). In SILC, participants","text_display":" (44), participants were average age \\(70.6 \\pm 10.3\\) and the average ABI was \\(0.61 \\pm 0.17\\). In SILC, participants","confidence":0.57763671875,"confidence_rate":0.9951974454427513},{"cnt":[[120,1830],[1871,1830],[1871,1880],[120,1880]],"region":{"top_left_x":120,"top_left_y":1830,"width":1752,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86a4eb2b30424620a9e6325a1c24a944","type":"text","conversion_output":true,"text":"included \\(52 \\%\\) women and \\(45 \\%\\) African-Americans. In general, patients with PAD have a relatively high","text_display":" included \\(52 \\%\\) women and \\(45 \\%\\) African-Americans. In general, patients with PAD have a relatively high","confidence":1,"confidence_rate":1},{"cnt":[[120,1876],[1906,1876],[1906,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1875,"width":1786,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d15fec99ecb423c9830067e3e536bd5","type":"text","conversion_output":true,"text":"prevalence of comorbid diseases, particularly coronary artery disease, cerebrovascular disease, diabetes","text_display":" prevalence of comorbid diseases, particularly coronary artery disease, cerebrovascular disease, diabetes","confidence":1,"confidence_rate":1},{"cnt":[[120,1919],[2002,1919],[2002,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1883,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42f5be9d5eb44b9aaa58f0b4b7b96302","type":"text","conversion_output":true,"text":"mellitus, and pulmonary disease. Thus the patient population is likely to be of generally poorer health than that","text_display":" mellitus, and pulmonary disease. Thus the patient population is likely to be of generally poorer health than that","confidence":1,"confidence_rate":1},{"cnt":[[120,1964],[2000,1964],[2000,2013],[120,2013]],"region":{"top_left_x":120,"top_left_y":1963,"width":1881,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1deda735c3a4cfa944f75c145487647","type":"text","conversion_output":true,"text":"of similarly aged men and women without PAD in the general population. However, subjects must be willing to","text_display":" of similarly aged men and women without PAD in the general population. However, subjects must be willing to","confidence":0.998046875,"confidence_rate":0.9999825444841725},{"cnt":[[120,2007],[1871,2007],[1871,2056],[120,2056]],"region":{"top_left_x":120,"top_left_y":2006,"width":1752,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"383931e3645741bebafff421442a101a","type":"text","conversion_output":true,"text":"travel to the medical center three times weekly in order to participate. This requirement will necessarily","text_display":" travel to the medical center three times weekly in order to participate. This requirement will necessarily","confidence":1,"confidence_rate":1},{"cnt":[[120,2052],[1882,2052],[1882,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2051,"width":1763,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56568177570141909b7643d8bdf885be","type":"text","conversion_output":true,"text":"eliminate some potential participants who are more frail. Inclusion and exclusion criteria are provided in","text_display":" eliminate some potential participants who are more frail. Inclusion and exclusion criteria are provided in","confidence":1,"confidence_rate":1},{"cnt":[[120,2093],[1996,2093],[1996,2144],[120,2144]],"region":{"top_left_x":120,"top_left_y":2092,"width":1876,"height":53},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48652ea506af4d1ab9d43ea500be1910","type":"text","conversion_output":true,"text":"sections C. 3 and C. 4 above. Vulnerable populations (fetuses, pregnant women, children, prisoners, and","text_display":" sections C. 3 and C. 4 above. Vulnerable populations (fetuses, pregnant women, children, prisoners, and","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[120,2140],[1205,2140],[1205,2189],[120,2189]],"region":{"top_left_x":120,"top_left_y":2139,"width":1086,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e10f74605c414936abe717f8557331ef","type":"text","conversion_output":true,"text":"institutionalized persons) will not be included in this study.","text_display":" institutionalized persons) will not be included in this study.","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1893,2226],[1893,2275],[120,2275]],"region":{"top_left_x":120,"top_left_y":2225,"width":1773,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed262d542f9c48e08440e6f5033dcc8b","type":"text","conversion_output":true,"text":"Sources of material. Primary and secondary outcome measures that will be collected for this study are","text_display":"\n\nSources of material. Primary and secondary outcome measures that will be collected for this study are","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[1824,2269],[1824,2318],[120,2320]],"region":{"top_left_x":120,"top_left_y":2268,"width":1705,"height":53},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f2aa6088b6842c687e24419ba229e3c","type":"text","conversion_output":true,"text":"shown in Table 6 and include the six-minute walk test, treadmill walking performance, progenitor cell","text_display":" shown in Table 6 and include the six-minute walk test, treadmill walking performance, progenitor cell","confidence":1,"confidence_rate":1},{"cnt":[[120,2314],[1858,2314],[1858,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2313,"width":1739,"height":49},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1486e7bc46994f55940cf96eea6be80c","type":"text","conversion_output":true,"text":"measures, and brachial artery flow-mediated dilation (FMD). We will also administer questionnaires to","text_display":" measures, and brachial artery flow-mediated dilation (FMD). We will also administer questionnaires to","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1880,2359],[1880,2408],[120,2408]],"region":{"top_left_x":120,"top_left_y":2358,"width":1760,"height":51},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e3f11dfc89c54a8ba4394a42c100ff17","type":"text","conversion_output":true,"text":"participants at baseline and at each follow-up visit to assess their medical history, including presence of","text_display":" participants at baseline and at each follow-up visit to assess their medical history, including presence of","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1979,2402],[1979,2451],[120,2451]],"region":{"top_left_x":120,"top_left_y":2401,"width":1859,"height":51},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a09c36005f6a44b4883b2c302b799c19","type":"text","conversion_output":true,"text":"comorbidities, medication use, smoking status, and other health characteristics. Data collection will not make","text_display":" comorbidities, medication use, smoking status, and other health characteristics. Data collection will not make","confidence":1,"confidence_rate":1},{"cnt":[[120,2445],[2000,2445],[2000,2494],[120,2494]],"region":{"top_left_x":120,"top_left_y":2444,"width":1881,"height":51},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6b6eefc680f46c1acb4d656ba2b69e2","type":"text","conversion_output":true,"text":"use of existing records or data. The prevalence of comorbid disease will be measured based on patient report,","text_display":" use of existing records or data. The prevalence of comorbid disease will be measured based on patient report,","confidence":1,"confidence_rate":1},{"cnt":[[120,2488],[1124,2488],[1124,2539],[120,2539]],"region":{"top_left_x":120,"top_left_y":2487,"width":1004,"height":53},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9853240463ae42c9a2b8a90b3d283b24","type":"text","conversion_output":true,"text":"based on previous study (91-95) (see section C. 15 above).","text_display":" based on previous study (91-95) (see section C. 15 above).","confidence":0.99951171875,"confidence_rate":0.9999926000198329},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"101f5c3cc66d48c9bc71bae1bef13565","type":"page_info","conversion_output":false,"text":"17","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-18","page":18,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8690b14daebc4ad1b4b9a998b3430fdb","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,163],[1738,163]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b667e8e947b642b9a41f24b6d5292549","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1914,206],[1914,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1795,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fb431a5c2be4aa090d74f7465f610b1","type":"text","conversion_output":true,"text":"Potential risks. GM-CSF is an FDA-approved medication, available commercially. GM-CSF is produced","text_display":"\n\nPotential risks. GM-CSF is an FDA-approved medication, available commercially. GM-CSF is produced","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[1983,249],[1983,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1864,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"812940f913e141dcb1fb66551d0b50c0","type":"text","conversion_output":true,"text":"using recombinant DNA technology. Side effects of GM-CSF include myalgias, arthralgias, fever, fatigue, and","text_display":" using recombinant DNA technology. Side effects of GM-CSF include myalgias, arthralgias, fever, fatigue, and","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,294],[1983,294],[1983,342],[120,342]],"region":{"top_left_x":120,"top_left_y":294,"width":1864,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01a9ebd703434b468924621b2edcb1aa","type":"text","conversion_output":true,"text":"headache (99, 100, 101). Splenic enlargement, usually subclinical, can occur. Splenic rupture related to GM-","text_display":" headache (99, 100, 101). Splenic enlargement, usually subclinical, can occur. Splenic rupture related to GM","confidence":0.8519124984741211,"confidence_rate":0.9985826738633978},{"cnt":[[120,339],[1966,339],[1966,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1846,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"add48f6dcb8f4bd3b96d445b5c666f9c","type":"text","conversion_output":true,"text":"CSF therapy is rare (100). Additional rare but serious side effects, such as allergy or thrombotic events have","text_display":"CSF therapy is rare (100). Additional rare but serious side effects, such as allergy or thrombotic events have","confidence":0.9990236759185791,"confidence_rate":0.999991506114367},{"cnt":[[120,382],[569,382],[569,432],[120,432]],"region":{"top_left_x":120,"top_left_y":382,"width":450,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90e72ce141da41c79c8f1679d5bd6af0","type":"text","conversion_output":true,"text":"also been observed (101).","text_display":" also been observed (101).","confidence":1,"confidence_rate":1},{"cnt":[[120,471],[1910,471],[1910,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1790,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7abb98298324856b5b1e04035349fe1","type":"text","conversion_output":true,"text":"The exercise program might be associated with an increased risk of heart attack, arrhythmia, or death. In","text_display":"\n\nThe exercise program might be associated with an increased risk of heart attack, arrhythmia, or death. In","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1983,516],[1983,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1864,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"365f25ea19404892851330af78ddd283","type":"text","conversion_output":true,"text":"addition, patients may develop ischemic chest pains during exercise. If participants develop chest pain during","text_display":" addition, patients may develop ischemic chest pains during exercise. If participants develop chest pain during","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1904,559],[1904,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1784,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5d7cc9435864de7abe169bbae306f28","type":"text","conversion_output":true,"text":"exercise, Dr. McDermott, Dr. Lloyd-Jones, or Dr. Losordo will be notified immediately. Dr. McDermott will","text_display":" exercise, Dr. McDermott, Dr. Lloyd-Jones, or Dr. Losordo will be notified immediately. Dr. McDermott will","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1863,602],[1863,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1743,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"735bfa8ce6214d2a8ba93fb0f0b13582","type":"text","conversion_output":true,"text":"oversee arrangement of appropriate follow-up (including immediate transport to the emergency room if","text_display":" oversee arrangement of appropriate follow-up (including immediate transport to the emergency room if","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1919,645],[1919,694],[120,694]],"region":{"top_left_x":120,"top_left_y":644,"width":1799,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da06bcab95724cd4ab6a4e71281bc917","type":"text","conversion_output":true,"text":"appropriate). The exercise physiologist is certified in Cardiopulmonary Resuscitation (CPR) and use of an","text_display":" appropriate). The exercise physiologist is certified in Cardiopulmonary Resuscitation (CPR) and use of an","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[120,690],[1979,690],[1979,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1859,"height":48},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f4374ab807f40178fbd50654f372c94","type":"text","conversion_output":true,"text":"Automatic External Defibrillator (AED). Safety manuals and protocols will be developed prior to beginning the","text_display":" Automatic External Defibrillator (AED). Safety manuals and protocols will be developed prior to beginning the","confidence":1,"confidence_rate":1},{"cnt":[[120,735],[1962,735],[1962,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1842,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee3f046005124bff83871ee067038ee8","type":"text","conversion_output":true,"text":"intervention. Chest pain symptoms during exercise may result in additional cardiac work-up that may lead to","text_display":" intervention. Chest pain symptoms during exercise may result in additional cardiac work-up that may lead to","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1858,778],[1858,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1739,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddde5c8e11fd497084e288be4af46631","type":"text","conversion_output":true,"text":"procedures to improve coronary blood flow. Subjects will be screened for active heart problems with a","text_display":" procedures to improve coronary blood flow. Subjects will be screened for active heart problems with a","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,821],[1837,821],[1837,868],[120,868]],"region":{"top_left_x":120,"top_left_y":820,"width":1717,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7c1366d211b5474d9e5cba3013f3734b","type":"text","conversion_output":true,"text":"baseline exercise treadmill test prior to enrollment, according to currently recommended standards of","text_display":" baseline exercise treadmill test prior to enrollment, according to currently recommended standards of","confidence":1,"confidence_rate":1},{"cnt":[[120,864],[1962,864],[1962,913],[120,913]],"region":{"top_left_x":120,"top_left_y":863,"width":1842,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1364077cbfe64b14962841068c3c607d","type":"text","conversion_output":true,"text":"screening PAD patients for coronary artery disease prior to their beginning an exercise program (35). These","text_display":" screening PAD patients for coronary artery disease prior to their beginning an exercise program (35). These","confidence":0.9956073760986328,"confidence_rate":0.9999606945240943},{"cnt":[[120,907],[1940,907],[1940,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1821,"height":51},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e22f3ee4ee8e48faad99f3764896863e","type":"text","conversion_output":true,"text":"exercise stress tests will be performed as part of our protocol and interpreted by board-certified cardiologist","text_display":" exercise stress tests will be performed as part of our protocol and interpreted by board-certified cardiologist","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1880,954],[1880,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1760,"height":47},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4fea0643f8f545f98143e4d3e3631f46","type":"text","conversion_output":true,"text":"and co-investigator Dr. Lloyd-Jones. Participants must have a normal 12-lead exercise stress test to be","text_display":" and co-investigator Dr. Lloyd-Jones. Participants must have a normal 12-lead exercise stress test to be","confidence":0.607421875,"confidence_rate":0.9953946031343528},{"cnt":[[120,997],[1944,997],[1944,1044],[120,1044]],"region":{"top_left_x":120,"top_left_y":996,"width":1825,"height":49},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d15b2491c254acbbcd9d7c64bf303ba","type":"text","conversion_output":true,"text":"eligible. Abnormal baseline exercise stress tests may lead to additional cardiac work-up by the participant's","text_display":" eligible. Abnormal baseline exercise stress tests may lead to additional cardiac work-up by the participant's","confidence":1,"confidence_rate":1},{"cnt":[[120,1040],[1987,1040],[1987,1089],[120,1089]],"region":{"top_left_x":120,"top_left_y":1039,"width":1868,"height":51},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5841d53f2afa449b9ebfb499b6480aa5","type":"text","conversion_output":true,"text":"physician that may lead to coronary angiography or coronary revascularization. If the baseline exercise stress","text_display":" physician that may lead to coronary angiography or coronary revascularization. If the baseline exercise stress","confidence":1,"confidence_rate":1},{"cnt":[[120,1085],[1876,1085],[1876,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1084,"width":1756,"height":49},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dac9df5443942b589af10b2b06c92ed","type":"text","conversion_output":true,"text":"test is equivocal or abnormal, the participant must demonstrate evidence of a recent (within the past six","text_display":" test is equivocal or abnormal, the participant must demonstrate evidence of a recent (within the past six","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1927,1130],[1927,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1808,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1c258651fc14a54ac1e9aeefc9be316","type":"text","conversion_output":true,"text":"months) normal coronary perfusion test or coronary angiogram in order to be eligible for participation. The","text_display":" months) normal coronary perfusion test or coronary angiogram in order to be eligible for participation. The","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1422,1173],[1422,1222],[120,1222]],"region":{"top_left_x":120,"top_left_y":1173,"width":1303,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d750e76959ac487bad1ea7401b02c0f4","type":"text","conversion_output":true,"text":"latter tests would be ordered by the participant's physician at their discretion.","text_display":" latter tests would be ordered by the participant's physician at their discretion.","confidence":1,"confidence_rate":1},{"cnt":[[120,1259],[1955,1259],[1955,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1258,"width":1836,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bc1eca71a6c47e192361202ccc81235","type":"text","conversion_output":true,"text":"Exercise may also be associated with muscle fatigue or soreness or dehydration which can result in fainting.","text_display":"\n\nExercise may also be associated with muscle fatigue or soreness or dehydration which can result in fainting.","confidence":1,"confidence_rate":1},{"cnt":[[120,1302],[1992,1302],[1992,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1872,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"958bc33dfa204d38b200e94db8eba639","type":"text","conversion_output":true,"text":"This typically resolves with rest. The risks associated with baseline and follow-up testing include discomfort or","text_display":" This typically resolves with rest. The risks associated with baseline and follow-up testing include discomfort or","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1910,1349],[1910,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1790,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3af3dbfd7954a7ea0e7bb239de70bbc","type":"text","conversion_output":true,"text":"pain in the extremities during the ankle brachial index test and falling during the walking tests. The ankle","text_display":" pain in the extremities during the ankle brachial index test and falling during the walking tests. The ankle","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1858,1392],[1858,1439],[120,1439]],"region":{"top_left_x":120,"top_left_y":1392,"width":1739,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f4fb37b7ab94da8af30ce3edfbfc24f","type":"text","conversion_output":true,"text":"brachial index will be aborted if a participant experiences severe pain during the testing. The research","text_display":" brachial index will be aborted if a participant experiences severe pain during the testing. The research","confidence":1,"confidence_rate":1},{"cnt":[[120,1435],[1906,1435],[1906,1485],[120,1485]],"region":{"top_left_x":120,"top_left_y":1435,"width":1786,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0f339270fff4976ae799c68e77f00a1","type":"text","conversion_output":true,"text":"assistant collecting these data has been trained to prevent falling. The risk of falling is less than 1 in 200.","text_display":" assistant collecting these data has been trained to prevent falling. The risk of falling is less than 1 in 200.","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[120,1480],[1987,1480],[1987,1528],[120,1528]],"region":{"top_left_x":120,"top_left_y":1480,"width":1868,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4b9f371934ea4c29864e91074bbdff85","type":"text","conversion_output":true,"text":"Falling during these tests may be associated with fracture. The risk of a fracture secondary to a fall during the","text_display":" Falling during these tests may be associated with fracture. The risk of a fracture secondary to a fall during the","confidence":1,"confidence_rate":1},{"cnt":[[120,1525],[741,1525],[741,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":622,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8f307778f1d9422f8fc77679bd19fb66","type":"text","conversion_output":true,"text":"walking tests is less than 1 in 5,000.","text_display":" walking tests is less than 1 in 5,000.","confidence":0.99609375,"confidence_rate":0.9999149188517554},{"cnt":[[120,1611],[1852,1611],[1852,1661],[120,1661]],"region":{"top_left_x":120,"top_left_y":1611,"width":1732,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b41f4b008556499789e1d995aaac48ac","type":"text","conversion_output":true,"text":"D2. Adequacy of protection against risk. Recruitment methods are described in section C5 above.","text_display":"\n\nD2. Adequacy of protection against risk. Recruitment methods are described in section C5 above.","confidence":1,"confidence_rate":1},{"cnt":[[120,1654],[1962,1654],[1962,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1654,"width":1842,"height":50},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"762d9352de9d47f7b95669670ebd2f70","type":"text","conversion_output":true,"text":"Informed consent will be obtained at the time of the initial study visit. Subjects will be asked to read and sign","text_display":" Informed consent will be obtained at the time of the initial study visit. Subjects will be asked to read and sign","confidence":1,"confidence_rate":1},{"cnt":[[120,1697],[1921,1697],[1921,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1801,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6951ad01f684e91be161938a840e6d4","type":"text","conversion_output":true,"text":"the study consent form. A research assistant will administer the consent form and answer questions. The","text_display":" the study consent form. A research assistant will administer the consent form and answer questions. The","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[1979,1745],[1979,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1859,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7355e99853046b4845af5f7c962a5fa","type":"text","conversion_output":true,"text":"research staff has undergone human subjects training required by our institutional review board. This training","text_display":" research staff has undergone human subjects training required by our institutional review board. This training","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1944,1788],[1944,1835],[120,1835]],"region":{"top_left_x":120,"top_left_y":1787,"width":1825,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae5aca3c711c4f318a37c3f12472eb07","type":"text","conversion_output":true,"text":"includes information about the importance of maintaining confidentiality of personal health information. The","text_display":" includes information about the importance of maintaining confidentiality of personal health information. The","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1979,1830],[1979,1880],[120,1880]],"region":{"top_left_x":120,"top_left_y":1830,"width":1859,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cdcc5a9fbc64095bd01b76a05b8b566","type":"text","conversion_output":true,"text":"study principal investigator or a co-investigator will be available to answer any questions as needed. Both the","text_display":" study principal investigator or a co-investigator will be available to answer any questions as needed. Both the","confidence":1,"confidence_rate":1},{"cnt":[[120,1873],[1562,1873],[1562,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1873,"width":1442,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d26467fca154e6a946a3a6c78949e97","type":"text","conversion_output":true,"text":"subjects and the individual administering the consent form will sign the consent form.","text_display":" subjects and the individual administering the consent form will sign the consent form.","confidence":1,"confidence_rate":1},{"cnt":[[120,1962],[1858,1962],[1858,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1961,"width":1739,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"757ae3a6ad3c4d12af0276a83c8e74c7","type":"text","conversion_output":true,"text":"Methods to minimize potential risks. Minimizing risks related to GM-CSF. The GM-CSF dose to be","text_display":"\n\nMethods to minimize potential risks. Minimizing risks related to GM-CSF. The GM-CSF dose to be","confidence":1,"confidence_rate":1},{"cnt":[[120,2007],[2000,2007],[2000,2056],[120,2056]],"region":{"top_left_x":120,"top_left_y":2006,"width":1881,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6bf3883c519415f8643500b65f3c42d","type":"text","conversion_output":true,"text":"administered is an FDA-approved dose with demonstrated safety in participants with PAD (1). GM-CSF will be","text_display":" administered is an FDA-approved dose with demonstrated safety in participants with PAD (1). GM-CSF will be","confidence":1,"confidence_rate":1},{"cnt":[[120,2050],[1987,2050],[1987,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2049,"width":1868,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4605e44e7f142e7933546bf9b9f0b1c","type":"text","conversion_output":true,"text":"administered in our clinical research unit (CRU) by a registered nurse, who has experience administering GM-","text_display":" administered in our clinical research unit (CRU) by a registered nurse, who has experience administering GM","confidence":1,"confidence_rate":1},{"cnt":[[120,2093],[1931,2093],[1931,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2092,"width":1812,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"abee701f6d314e4985a35f7c55289d50","type":"text","conversion_output":true,"text":"CSF, or a physician. 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Potential","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1936,339],[1936,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1816,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"498f573cb0b54baa97e6b879d76b3bbc","type":"text","conversion_output":true,"text":"participants with an abnormal baseline exercise stress test will be excluded. A physical examination will be","text_display":" participants with an abnormal baseline exercise stress test will be excluded. A physical examination will be","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[1893,382],[1893,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1773,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b6ff1991bab49a087829483bab11a6e","type":"text","conversion_output":true,"text":"completed by a physician during baseline assessments to help ensure that study participation is safe. In","text_display":" completed by a physician during baseline assessments to help ensure that study participation is safe. In","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1966,425],[1966,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1846,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0754f41513f64ff5bf3ca1870c65978c","type":"text","conversion_output":true,"text":"addition, participants will be monitored during exercise for development of chest discomfort, new dyspnea, or","text_display":" addition, participants will be monitored during exercise for development of chest discomfort, new dyspnea, or","confidence":1,"confidence_rate":1},{"cnt":[[120,471],[2004,471],[2004,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1885,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b11792f7cf14da5afc5efd888674910","type":"text","conversion_output":true,"text":"new fatigue during exertion. Dr. McDermott will be promptly notified when this occurs (by pager). Our exercise","text_display":" new fatigue during exertion. Dr. McDermott will be promptly notified when this occurs (by pager). Our exercise","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1880,516],[1880,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1760,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"04486eea3be5484a893ab47cb173199c","type":"text","conversion_output":true,"text":"physiologists have significant experience working with populations of participants with peripheral arterial","text_display":" physiologists have significant experience working with populations of participants with peripheral arterial","confidence":1,"confidence_rate":1},{"cnt":[[120,559],[1697,559],[1697,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1578,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12e82c294540453eba2639192ffacdfa","type":"text","conversion_output":true,"text":"disease and have been trained in CPR, ACLS, and use of the automatic external defibrillator.","text_display":" disease and have been trained in CPR, ACLS, and use of the automatic external defibrillator.","confidence":1,"confidence_rate":1},{"cnt":[[120,645],[1974,645],[1974,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1855,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ef4135e6cae4658a0fd445e82e55d18","type":"text","conversion_output":true,"text":"Minimizing risk related to baseline and follow-up testing. All study coordinators undergo baseline training and","text_display":"\n\nMinimizing risk related to baseline and follow-up testing. All study coordinators undergo baseline training and","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1944,690],[1944,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1825,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"229b9ef219f7481b87705341bf522c0f","type":"text","conversion_output":true,"text":"are certified by Dr. McDermott before beginning data collection. Training and certification involves ensuring","text_display":" are certified by Dr. McDermott before beginning data collection. 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Dr. McDermott re-certifies coordinators every","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1987,778],[1987,825],[120,825]],"region":{"top_left_x":120,"top_left_y":777,"width":1868,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1b2bf8553fb49fa94a52f089c11992f","type":"text","conversion_output":true,"text":"six months to ensure continued adherence to study protocol. Those who are not adhering to protocol undergo","text_display":" six months to ensure continued adherence to study protocol. Those who are not adhering to protocol undergo","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[889,821],[889,868],[120,868]],"region":{"top_left_x":120,"top_left_y":820,"width":770,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad26cf86bc614d4da422ed936193dc48","type":"text","conversion_output":true,"text":"additional training followed by re-certification.","text_display":" additional training followed by re-certification.","confidence":1,"confidence_rate":1},{"cnt":[[120,907],[1800,907],[1800,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1681,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9bba3565957344f0b8bcb29f667c7837","type":"text","conversion_output":true,"text":"Minimizing risk related to loss of confidentiality. A number of methods will be employed to maintain","text_display":"\n\nMinimizing risk related to loss of confidentiality. A number of methods will be employed to maintain","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1992,954],[1992,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1872,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d39247a6ca5b492f884a07b8f1569c03","type":"text","conversion_output":true,"text":"confidentiality of participants. First, study recruitment letters will be mailed, using IRB-approved methods, only","text_display":" confidentiality of participants. First, study recruitment letters will be mailed, using IRB-approved methods, only","confidence":1,"confidence_rate":1},{"cnt":[[120,997],[1886,997],[1886,1044],[120,1044]],"region":{"top_left_x":120,"top_left_y":996,"width":1767,"height":49},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"75473dd18e9246ec9346636ebb2722d9","type":"text","conversion_output":true,"text":"after receiving written permission from the participant's physician. The personal physician of each study","text_display":" after receiving written permission from the participant's physician. The personal physician of each study","confidence":1,"confidence_rate":1},{"cnt":[[120,1042],[1867,1042],[1867,1089],[120,1089]],"region":{"top_left_x":120,"top_left_y":1041,"width":1747,"height":49},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d33f18eaa15740fba8ad0352f0efd364","type":"text","conversion_output":true,"text":"participant will have the option of not allowing investigators to contact the potential participant. Lists of","text_display":" participant will have the option of not allowing investigators to contact the potential participant. 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Recruitment letters for potential participants identified from hospital and","text_display":" their daily work requirements. Recruitment letters for potential participants identified from hospital and","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1843,1173],[1843,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1724,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7d34a4a2d9a40d49aa3af34ff10fb92","type":"text","conversion_output":true,"text":"outpatient lists are prepared by research staff members whose job is to assist study investigators with","text_display":" outpatient lists are prepared by research staff members whose job is to assist study investigators with","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[1962,1216],[1962,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1842,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c109e81e996b4338964d0802d97c4512","type":"text","conversion_output":true,"text":"recruitment. These research staff members have completed training in the ethical conduct of human subject","text_display":" recruitment. These research staff members have completed training in the ethical conduct of human subject","confidence":1,"confidence_rate":1},{"cnt":[[120,1259],[2004,1259],[2004,1308],[120,1308]],"region":{"top_left_x":120,"top_left_y":1258,"width":1885,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20b4def7393e4d1c810fad30d8c453ac","type":"text","conversion_output":true,"text":"research, including maintaining participant confidentiality. Recruitment letters to potential participants identified","text_display":" research, including maintaining participant confidentiality. Recruitment letters to potential participants identified","confidence":1,"confidence_rate":1},{"cnt":[[120,1302],[1863,1302],[1863,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1743,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"415626b7afe247d38c577f0d83f2eefc","type":"text","conversion_output":true,"text":"from medical center lists are mailed in sealed envelopes and addressed to the potential participant. All","text_display":" from medical center lists are mailed in sealed envelopes and addressed to the potential participant. All","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[2000,1349],[2000,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1881,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"185d92349f2741a9a9c5e9813d76717f","type":"text","conversion_output":true,"text":"potential participants who receive mailed information about the study after the approval from their physician will","text_display":" potential participants who receive mailed information about the study after the approval from their physician will","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1815,1392],[1815,1439],[120,1439]],"region":{"top_left_x":120,"top_left_y":1392,"width":1696,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c022ee479c1242a19366dadd06d45c01","type":"text","conversion_output":true,"text":"have the opportunity to call a voice-mail system to ask NOT to be further contacted about this study.","text_display":" have the opportunity to call a voice-mail system to ask NOT to be further contacted about this study.","confidence":1,"confidence_rate":1},{"cnt":[[120,1435],[1880,1435],[1880,1482],[120,1482]],"region":{"top_left_x":120,"top_left_y":1435,"width":1760,"height":48},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f2bd143fd4d4bb4ab4c62d8eaf174de","type":"text","conversion_output":true,"text":"Secondly, only study investigators and key research staff will have access to the study database. 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Individual names will ultimately be removed from the","confidence":1,"confidence_rate":1},{"cnt":[[120,1525],[1921,1525],[1921,1571],[120,1571]],"region":{"top_left_x":120,"top_left_y":1525,"width":1801,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61eed6816dc54571bbdd477cf09d87cc","type":"text","conversion_output":true,"text":"study database and only the unique study identifier will be used to distinguish participants in the database.","text_display":" study database and only the unique study identifier will be used to distinguish participants in the database.","confidence":1,"confidence_rate":1},{"cnt":[[120,1568],[1841,1568],[1841,1616],[120,1616]],"region":{"top_left_x":120,"top_left_y":1568,"width":1722,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"759e0dd226424a629966630c0d94c158","type":"text","conversion_output":true,"text":"Fourth, collected data will be maintained in locked computer files and file cabinets to which only study","text_display":" Fourth, collected data will be maintained in locked computer files and file cabinets to which only study","confidence":1,"confidence_rate":1},{"cnt":[[120,1611],[2002,1611],[2002,1661],[120,1661]],"region":{"top_left_x":120,"top_left_y":1611,"width":1883,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de6c15fc0cba452084f6a914d8230ed9","type":"text","conversion_output":true,"text":"investigators have access. Collected data will be used only for research purposes. Any published data will not","text_display":" investigators have access. Collected data will be used only for research purposes. Any published data will not","confidence":1,"confidence_rate":1},{"cnt":[[120,1659],[677,1659],[677,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1658,"width":557,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae35544a9040418b8ec55125f03e26fc","type":"text","conversion_output":true,"text":"contain any individual identifiers.","text_display":" contain any individual identifiers.","confidence":1,"confidence_rate":1},{"cnt":[[120,1742],[1946,1742],[1946,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1742,"width":1827,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d978c2e32f954b7aace281ab589ac1d6","type":"text","conversion_output":true,"text":"Data and Safety Monitoring Board (DSMB). As per NHLBI guidelines, the DSMB will be appointed by the","text_display":"\n\nData and Safety Monitoring Board (DSMB). As per NHLBI guidelines, the DSMB will be appointed by the","confidence":0.99755859375,"confidence_rate":0.9999764965133096},{"cnt":[[120,1788],[1996,1788],[1996,1835],[120,1835]],"region":{"top_left_x":120,"top_left_y":1787,"width":1876,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb80cf8fc0564c8fbe4159f717dea19d","type":"text","conversion_output":true,"text":"NHLBI. The DSMB will meet at least every six months during the study. They will meet to review and approve","text_display":" NHLBI. The DSMB will meet at least every six months during the study. They will meet to review and approve","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1895,1830],[1895,1880],[120,1880]],"region":{"top_left_x":120,"top_left_y":1830,"width":1775,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d190d33b0dc4934b6e2c970c33a9b3e","type":"text","conversion_output":true,"text":"the protocol prior to beginning data collection. They will decide on specific stopping criteria for the study.","text_display":" the protocol prior to beginning data collection. They will decide on specific stopping criteria for the study.","confidence":1,"confidence_rate":1},{"cnt":[[120,1876],[2002,1876],[2002,1923],[120,1923]],"region":{"top_left_x":120,"top_left_y":1875,"width":1883,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0875dcda42f42cc930b5f93c3264a7c","type":"text","conversion_output":true,"text":"However, because of the short duration of the study and because of our secondary and exploratory aims, there","text_display":" However, because of the short duration of the study and because of our secondary and exploratory aims, there","confidence":1,"confidence_rate":1},{"cnt":[[120,1919],[1970,1919],[1970,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1851,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3539f4bcbe6b420f8c9703e501511b82","type":"text","conversion_output":true,"text":"will be no criteria for stopping due to benefit. The biostatisticians and data manager will work closely with the","text_display":" will be no criteria for stopping due to benefit. The biostatisticians and data manager will work closely with the","confidence":1,"confidence_rate":1},{"cnt":[[120,1964],[1886,1964],[1886,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1767,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"debf3d3408534f85b3b83ac993b4dc50","type":"text","conversion_output":true,"text":"DSMB to perform interim analyses. However, since the sample size is small and the follow-up is only six","text_display":" DSMB to perform interim analyses. However, since the sample size is small and the follow-up is only six","confidence":1,"confidence_rate":1},{"cnt":[[120,2007],[1923,2007],[1923,2056],[120,2056]],"region":{"top_left_x":120,"top_left_y":2006,"width":1803,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42745f509590478ca8685c845bf80d64","type":"text","conversion_output":true,"text":"months, we do not plan to have any stopping criteria for beneficial effect. Rather, we will develop stopping","text_display":" months, we do not plan to have any stopping criteria for beneficial effect. Rather, we will develop stopping","confidence":1,"confidence_rate":1},{"cnt":[[120,2054],[657,2054],[657,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2053,"width":538,"height":47},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb43667724124631bcad18b6962c1cb3","type":"text","conversion_output":true,"text":"criteria only for adverse effects.","text_display":" criteria only for adverse effects.","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1992,2140],[1992,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1872,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cd2eb64c0724b07bc76e21c4e932819","type":"text","conversion_output":true,"text":"Adverse events will be monitored continuously throughout the study and will be reported to the DSMB and IRB","text_display":"\n\nAdverse events will be monitored continuously throughout the study and will be reported to the DSMB and IRB","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1985,2183],[1985,2230],[120,2230]],"region":{"top_left_x":120,"top_left_y":2182,"width":1866,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ace5bf4f431435eba4ec46a5246e273","type":"text","conversion_output":true,"text":"in a timely manner according to pre-specified requirements. Adverse event rates and interim study results will","text_display":" in a timely manner according to pre-specified requirements. Adverse event rates and interim study results will","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[1953,2226],[1953,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2225,"width":1833,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab40a645c56f44cea74e7f1aae39d6ee","type":"text","conversion_output":true,"text":"be reviewed and discussed by the DSMB at the DSMB meetings. At least four categories of adverse events","text_display":" be reviewed and discussed by the DSMB at the DSMB meetings. At least four categories of adverse events","confidence":1,"confidence_rate":1},{"cnt":[[120,2269],[2004,2269],[2004,2318],[120,2318]],"region":{"top_left_x":120,"top_left_y":2268,"width":1885,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"42dcef6d1a5f476a9fb7522d13ef421a","type":"text","conversion_output":true,"text":"will be defined: a) Death; b) cardiovascular events (myocardial infarction, stroke, and coronary arrhythmias) c)","text_display":" will be defined: a) Death; b) cardiovascular events (myocardial infarction, stroke, and coronary arrhythmias) c)","confidence":1,"confidence_rate":1},{"cnt":[[120,2316],[1835,2316],[1835,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2316,"width":1715,"height":46},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"970c51aea4fb4eaa930205087a2bfb6d","type":"text","conversion_output":true,"text":"musculoskeletal outcomes (muscle soreness, foot ulcer, joint aches and pains); d) additional adverse","text_display":" musculoskeletal outcomes (muscle soreness, foot ulcer, joint aches and pains); d) additional adverse","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1996,2359],[1996,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1876,"height":47},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d528282a0454e578e744d94b151b002","type":"text","conversion_output":true,"text":"symptoms and events (headache, fatigue, arthralgias, fever, allergy related to GM-CSF, splenic rupture related","text_display":" symptoms and events (headache, fatigue, arthralgias, fever, allergy related to GM-CSF, splenic rupture related","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1987,2402],[1987,2447],[120,2447]],"region":{"top_left_x":120,"top_left_y":2401,"width":1868,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f1554d4139849ac99b412e9612e2aa7","type":"text","conversion_output":true,"text":"to GM-CSF). We will also monitor all hospitalizations. We will use a designated data collection form to record","text_display":" to GM-CSF). We will also monitor all hospitalizations. We will use a designated data collection form to record","confidence":1,"confidence_rate":1},{"cnt":[[120,2445],[1972,2445],[1972,2494],[120,2494]],"region":{"top_left_x":120,"top_left_y":2444,"width":1853,"height":51},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e671dd1a72549eaa0c427be1adfc9b9","type":"text","conversion_output":true,"text":"these events and they will be reported immediately to the Institutional Review Board and DSMB. Note that to","text_display":" these events and they will be reported immediately to the Institutional Review Board and DSMB. Note that to","confidence":1,"confidence_rate":1},{"cnt":[[120,2488],[1906,2488],[1906,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":1786,"height":51},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4060486e9e2a42a8984240c8da350c42","type":"text","conversion_output":true,"text":"date, however, exercise programs and GM-CSF have been demonstrated to be safe in patients with PAD","text_display":" date, however, exercise programs and GM-CSF have been demonstrated to be safe in patients with PAD","confidence":1,"confidence_rate":1},{"cnt":[[120,2535],[290,2535],[290,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2535,"width":171,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fa9dc395c15748abbe8375ef927675cc","type":"text","conversion_output":true,"text":"\\((1,35,44)\\).","text_display":" \\((1,35,44)\\).","confidence":0.9834063053131104,"confidence_rate":0.9988850944843739},{"cnt":[[1038,2582],[1089,2582],[1089,2628],[1038,2628]],"region":{"top_left_x":1037,"top_left_y":2582,"width":53,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ef032291a9b4e3aa2002c78f51c3352","type":"page_info","conversion_output":false,"text":"19","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-20","page":20,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2c123471e16640daa4d66110f0589054","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1738,129],[2004,129],[2004,165],[1738,165]],"region":{"top_left_x":1738,"top_left_y":128,"width":267,"height":38},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"431894b5426048918ef0d151b42448e6","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,249],[1972,249],[1972,296],[120,296]],"region":{"top_left_x":120,"top_left_y":249,"width":1853,"height":48},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c937ef8da5b24ba288fe536e8e071dbe","type":"text","conversion_output":true,"text":"The biostatisticians and data manager will work closely with the DSMB to perform interim analyses. However,","text_display":"\n\nThe biostatisticians and data manager will work closely with the DSMB to perform interim analyses. However,","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,296],[2002,296],[2002,342],[120,342]],"region":{"top_left_x":120,"top_left_y":296,"width":1883,"height":46},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e636a3856bfd4503b3c2df04e2e7b7f5","type":"text","conversion_output":true,"text":"since the sample size is small and the follow-up is only six months, we do not plan to have any stopping criteria","text_display":" since the sample size is small and the follow-up is only six months, we do not plan to have any stopping criteria","confidence":1,"confidence_rate":1},{"cnt":[[120,339],[1987,339],[1987,385],[120,385]],"region":{"top_left_x":120,"top_left_y":339,"width":1868,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2554e0d055694854b8296184b1a9f25a","type":"text","conversion_output":true,"text":"for beneficial effect. Rather, we will develop stopping criteria only for adverse effects. For the proposed semi-","text_display":" for beneficial effect. Rather, we will develop stopping criteria only for adverse effects. For the proposed semi","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[1968,382],[1968,428],[120,428]],"region":{"top_left_x":120,"top_left_y":382,"width":1848,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de39390072604fbe8fd1be9766682f2d","type":"text","conversion_output":true,"text":"annual DSMB meetings, data will be edited and cleaned contemporaneously to data collection. Analyses will","text_display":"annual DSMB meetings, data will be edited and cleaned contemporaneously to data collection. Analyses will","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1828,425],[1828,473],[120,473]],"region":{"top_left_x":120,"top_left_y":425,"width":1709,"height":48},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c52006fbd6804fc497f804ea354f6a09","type":"text","conversion_output":true,"text":"be done according to the requests of the DSMB. In addition, for each major adverse event, the group","text_display":" be done according to the requests of the DSMB. In addition, for each major adverse event, the group","confidence":1,"confidence_rate":1},{"cnt":[[120,473],[1830,473],[1830,518],[120,518]],"region":{"top_left_x":120,"top_left_y":472,"width":1711,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15ba2eefea634e7f9bda8b28468c99f6","type":"text","conversion_output":true,"text":"assignment of the patient will be provided. In this way the DSMB can determine whether the event is","text_display":" assignment of the patient will be provided. In this way the DSMB can determine whether the event is","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[462,516],[462,556],[120,556]],"region":{"top_left_x":120,"top_left_y":515,"width":342,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8cc47efc74246f385cd097f47663b3f","type":"text","conversion_output":true,"text":"intervention related.","text_display":" intervention related.","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[1987,602],[1987,647],[120,647]],"region":{"top_left_x":120,"top_left_y":601,"width":1868,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"553322a9975a439f9bd0527370bd22f1","type":"text","conversion_output":true,"text":"D3. Potential benefits of the proposed research. Preliminary evidence suggests that increasing circulating","text_display":"\n\nD3. Potential benefits of the proposed research. Preliminary evidence suggests that increasing circulating","confidence":0.99951171875,"confidence_rate":0.9999956000051925},{"cnt":[[120,645],[1949,645],[1949,692],[120,692]],"region":{"top_left_x":120,"top_left_y":644,"width":1829,"height":48},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"263982f834044fcebba1f83d38c52360","type":"text","conversion_output":true,"text":"levels of CD34+ cells with granulocyte monocyte colony stimulating factor (GM-CSF) or other therapies may","text_display":" levels of CD34+ cells with granulocyte monocyte colony stimulating factor (GM-CSF) or other therapies may","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1820,690],[1820,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1700,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe6cc40c26ae4bbe82789f0a3516f432","type":"text","conversion_output":true,"text":"improve walking performance in patients with lower extremity peripheral arterial disease (PAD) \\((1,2)\\).","text_display":" improve walking performance in patients with lower extremity peripheral arterial disease (PAD) \\((1,2)\\).","confidence":0.8173828125,"confidence_rate":0.9981685179855253},{"cnt":[[120,735],[1919,735],[1919,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1799,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df35f5cd4fca4ca89bdfcda8322e0595","type":"text","conversion_output":true,"text":"However, results of small clinical trials are mixed (1-4). The association of GM-CSF with improved walking","text_display":" However, results of small clinical trials are mixed (1-4). The association of GM-CSF with improved walking","confidence":0.9873046875,"confidence_rate":0.999884902240661},{"cnt":[[120,778],[1841,778],[1841,823],[120,823]],"region":{"top_left_x":120,"top_left_y":777,"width":1722,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71576e20e93346edb6812a38750ce0e0","type":"text","conversion_output":true,"text":"performance in PAD is not definitively established. Preliminary data also suggest that lower extremity","text_display":" performance in PAD is not definitively established. Preliminary data also suggest that lower extremity","confidence":1,"confidence_rate":1},{"cnt":[[120,821],[1927,821],[1927,866],[120,866]],"region":{"top_left_x":120,"top_left_y":820,"width":1808,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e0f69c7cc2f4b3eba7799835999a1cd","type":"text","conversion_output":true,"text":"ischemia, induced during walking exercise, may increase circulating CD34+ cell levels, enhance homing of","text_display":" ischemia, induced during walking exercise, may increase circulating CD34+ cell levels, enhance homing of","confidence":1,"confidence_rate":1},{"cnt":[[120,866],[1936,866],[1936,913],[120,913]],"region":{"top_left_x":120,"top_left_y":865,"width":1816,"height":49},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74f54258fef34ba5894bf6c3e5ca0e2d","type":"text","conversion_output":true,"text":"CD34+ cells to ischemic sites, and augment the ability of GM-CSF to improve walking performance in PAD","text_display":" CD34+ cells to ischemic sites, and augment the ability of GM-CSF to improve walking performance in PAD","confidence":0.9985356330871582,"confidence_rate":0.9999863043914873},{"cnt":[[120,911],[1893,911],[1893,956],[120,956]],"region":{"top_left_x":120,"top_left_y":910,"width":1773,"height":47},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14e00a9673fc41d7b2a5cfe521a6650e","type":"text","conversion_output":true,"text":"\\((1,2)\\). However, whether the combination of GM-CSF and supervised treadmill exercise improve walking","text_display":" \\((1,2)\\). However, whether the combination of GM-CSF and supervised treadmill exercise improve walking","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1949,954],[1949,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1829,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3bfd07df6faa44f082d372c9581d0c61","type":"text","conversion_output":true,"text":"performance more than GM-CSF and supervised treadmill exercise, respectively, is currently unknown. This","text_display":" performance more than GM-CSF and supervised treadmill exercise, respectively, is currently unknown. This","confidence":0.9990234375,"confidence_rate":0.9999910363736797},{"cnt":[[120,997],[1919,997],[1919,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":996,"width":1799,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33be50f0f7d442458975b7032955f1cd","type":"text","conversion_output":true,"text":"proposed clinical trial is needed to definitively establish a) whether the combination of supervised treadmill","text_display":" proposed clinical trial is needed to definitively establish a) whether the combination of supervised treadmill","confidence":1,"confidence_rate":1},{"cnt":[[120,1042],[1893,1042],[1893,1087],[120,1087]],"region":{"top_left_x":120,"top_left_y":1041,"width":1773,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9540d817d7d45d5907e2bcd9b067266","type":"text","conversion_output":true,"text":"exercise and GM-CSF improves functional performance in PAD participants with and without intermittent","text_display":" exercise and GM-CSF improves functional performance in PAD participants with and without intermittent","confidence":1,"confidence_rate":1},{"cnt":[[120,1087],[1992,1087],[1992,1132],[120,1132]],"region":{"top_left_x":120,"top_left_y":1087,"width":1872,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5c1be0fcf734783af33574baee7f678","type":"text","conversion_output":true,"text":"claudication more than either intervention individually; b) whether GM-CSF improves functional performance in","text_display":" claudication more than either intervention individually; b) whether GM-CSF improves functional performance in","confidence":0.9990234375,"confidence_rate":0.9999914295135003},{"cnt":[[120,1130],[1861,1130],[1861,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1741,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02368e9b489b46019c32d7497a23214b","type":"text","conversion_output":true,"text":"PAD patients with and without intermittent claudication as compared to placebo; c) whether supervised","text_display":" PAD patients with and without intermittent claudication as compared to placebo; c) whether supervised","confidence":0.98681640625,"confidence_rate":0.9998748071886348},{"cnt":[[120,1173],[2000,1173],[2000,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1881,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e443c1b534ed422389d9fc9c93a08057","type":"text","conversion_output":true,"text":"treadmill exercise increases circulating levels of CD34+ cells; d) whether the degree of increase in CD34+ cells","text_display":" treadmill exercise increases circulating levels of CD34+ cells; d) whether the degree of increase in CD34+ cells","confidence":0.99853515625,"confidence_rate":0.9999874708675287},{"cnt":[[120,1216],[1923,1216],[1923,1261],[120,1261]],"region":{"top_left_x":120,"top_left_y":1216,"width":1803,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b7c028fca0a2458db2fb5848faf56e22","type":"text","conversion_output":true,"text":"is associated with the degree of improvement in six-minute walk performance; e) the temporal trajectory of","text_display":" is associated with the degree of improvement in six-minute walk performance; e) the temporal trajectory of","confidence":0.9951221942901611,"confidence_rate":0.9999559492492534},{"cnt":[[120,1263],[1867,1263],[1867,1306],[120,1306]],"region":{"top_left_x":120,"top_left_y":1263,"width":1747,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a9e784b57894d0fbaccce8ddb74f1d2","type":"text","conversion_output":true,"text":"improvement in study outcomes in response to study interventions and increases in progenitor cells. In","text_display":" improvement in study outcomes in response to study interventions and increases in progenitor cells. In","confidence":1,"confidence_rate":1},{"cnt":[[120,1306],[1979,1306],[1979,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1306,"width":1859,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"363517dee0154794aeeba29b5d87fff9","type":"text","conversion_output":true,"text":"addition to establishing the therapeutic benefit of GM-CSF with and without supervised treadmill exercise, this","text_display":" addition to establishing the therapeutic benefit of GM-CSF with and without supervised treadmill exercise, this","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1987,1349],[1987,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1868,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffe0b05e035a453ba07a93cfbf3a5847","type":"text","conversion_output":true,"text":"proposed study is expected to identify biological pathways associated with improved functional performance in","text_display":" proposed study is expected to identify biological pathways associated with improved functional performance in","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1944,1392],[1944,1437],[120,1437]],"region":{"top_left_x":120,"top_left_y":1392,"width":1825,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddde88319e314e50bb0a21b4a9b09680","type":"text","conversion_output":true,"text":"patients with PAD. This information is expected to lead to new therapies to improve walking performance in","text_display":" patients with PAD. This information is expected to lead to new therapies to improve walking performance in","confidence":0.9990234375,"confidence_rate":0.9999911978797494},{"cnt":[[120,1437],[440,1437],[440,1480],[120,1480]],"region":{"top_left_x":120,"top_left_y":1437,"width":321,"height":44},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ddab222953a342879c6e93f032945886","type":"text","conversion_output":true,"text":"patients with PAD.","text_display":" patients with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[122,1525],[1974,1525],[1974,1571],[122,1571]],"region":{"top_left_x":122,"top_left_y":1525,"width":1853,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e0dc3fa8b9e424a8c20c22d0f7dd13a","type":"text","conversion_output":true,"text":"D4. Importance of knowledge to be gained. Lower extremity peripheral arterial disease (PAD) is common.","text_display":"\n\nD4. Importance of knowledge to be gained. Lower extremity peripheral arterial disease (PAD) is common.","confidence":1,"confidence_rate":1},{"cnt":[[120,1568],[1970,1568],[1970,1613],[120,1613]],"region":{"top_left_x":120,"top_left_y":1568,"width":1851,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a0ec3755f854764812902109b4a0b56","type":"text","conversion_output":true,"text":"Currently 8 million men and women in the United States (U.S.) have PAD (5). The number of individuals with","text_display":" Currently 8 million men and women in the United States (U.S.) have PAD (5). The number of individuals with","confidence":0.7962932586669922,"confidence_rate":0.9980038568299412},{"cnt":[[120,1611],[1944,1611],[1944,1659],[120,1659]],"region":{"top_left_x":120,"top_left_y":1611,"width":1825,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"11ce1e43df364fd5872c6196e3140acd","type":"text","conversion_output":true,"text":"PAD is expected to increase as the U.S. population lives to older ages with chronic disease. Our prior work","text_display":" PAD is expected to increase as the U.S. population lives to older ages with chronic disease. Our prior work","confidence":1,"confidence_rate":1},{"cnt":[[120,1659],[1858,1659],[1858,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1658,"width":1739,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8e880fc088a54fdda79b5894b7c256a0","type":"text","conversion_output":true,"text":"and that of others shows that patients with PAD have greater functional impairment, increased rates of","text_display":" and that of others shows that patients with PAD have greater functional impairment, increased rates of","confidence":1,"confidence_rate":1},{"cnt":[[120,1702],[1953,1702],[1953,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1701,"width":1833,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a09385b70fe046aeb032e77df52ac708","type":"text","conversion_output":true,"text":"functional decline, and increased mobility loss compared to persons without PAD (6-11). Older patients with","text_display":" functional decline, and increased mobility loss compared to persons without PAD (6-11). Older patients with","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[1783,1745],[1783,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":1664,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d197a7933bb47ea9e71fac8290bea50","type":"text","conversion_output":true,"text":"functional impairment are less likely to remain independent in the community, have higher rates of","text_display":" functional impairment are less likely to remain independent in the community, have higher rates of","confidence":1,"confidence_rate":1},{"cnt":[[120,1788],[1992,1788],[1992,1833],[120,1833]],"region":{"top_left_x":120,"top_left_y":1787,"width":1872,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d305c620af2a49dfa1b8035e30a0875d","type":"text","conversion_output":true,"text":"hospitalization, and have poorer quality of life than those without functional impairment (12). Yet few therapies","text_display":" hospitalization, and have poorer quality of life than those without functional impairment (12). Yet few therapies","confidence":1,"confidence_rate":1},{"cnt":[[120,1833],[1944,1833],[1944,1876],[120,1876]],"region":{"top_left_x":120,"top_left_y":1832,"width":1825,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31ccb346846e4cd4801523acc0e110b5","type":"text","conversion_output":true,"text":"have been identified that improve lower extremity functioning or prevent functional decline or mobility loss in","text_display":" have been identified that improve lower extremity functioning or prevent functional decline or mobility loss in","confidence":1,"confidence_rate":1},{"cnt":[[120,1878],[1996,1878],[1996,1921],[120,1921]],"region":{"top_left_x":120,"top_left_y":1877,"width":1876,"height":44},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f869dc18826c46b5bc6d603ea7b96d5f","type":"text","conversion_output":true,"text":"persons with PAD. Only two FDA-approved medications improve functional performance in patients with PAD.","text_display":" persons with PAD. Only two FDA-approved medications improve functional performance in patients with PAD.","confidence":0.99951171875,"confidence_rate":0.9999955192715237},{"cnt":[[120,1921],[1987,1921],[1987,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1920,"width":1868,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d93319a149d540a49165a66de495af19","type":"text","conversion_output":true,"text":"Identifying biological pathways associated with improved functional performance in PAD is expected to lead to","text_display":" Identifying biological pathways associated with improved functional performance in PAD is expected to lead to","confidence":1,"confidence_rate":1},{"cnt":[[120,1964],[1893,1964],[1893,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":1773,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c54446007b443d89c215e06b5c07153","type":"text","conversion_output":true,"text":"new therapies to help patients with PAD preserve their functional performance and avoid decline. These","text_display":" new therapies to help patients with PAD preserve their functional performance and avoid decline. These","confidence":1,"confidence_rate":1},{"cnt":[[120,2007],[1983,2007],[1983,2054],[120,2054]],"region":{"top_left_x":120,"top_left_y":2006,"width":1864,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6387e2ff3ad4022b931af47b77c2c60","type":"text","conversion_output":true,"text":"findings will have important public health implications for preventing disability and nursing home placement for","text_display":" findings will have important public health implications for preventing disability and nursing home placement for","confidence":1,"confidence_rate":1},{"cnt":[[120,2054],[625,2054],[625,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2053,"width":506,"height":47},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1e71f48585f74cb993572e1a517ef547","type":"text","conversion_output":true,"text":"a large number of individuals.","text_display":" a large number of individuals.","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[1880,2140],[1880,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1760,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0dd91b1abb2d4d52ba6e8a8f1ba59c06","type":"text","conversion_output":true,"text":"D5. Collaborating sites. Brachial artery flow-mediated dilation results will be interpreted by Dr. James","text_display":"\n\nD5. Collaborating sites. Brachial artery flow-mediated dilation results will be interpreted by Dr. James","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1867,2183],[1867,2228],[120,2228]],"region":{"top_left_x":120,"top_left_y":2182,"width":1747,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"71999ac04c2c4a1d8c3ba827a188bd16","type":"text","conversion_output":true,"text":"Stein's laboratory at the University of Wisconsin Medical School. Videotapes of the brachial artery flow","text_display":" Stein's laboratory at the University of Wisconsin Medical School. Videotapes of the brachial artery flow","confidence":1,"confidence_rate":1},{"cnt":[[120,2228],[1820,2228],[1820,2273],[120,2273]],"region":{"top_left_x":120,"top_left_y":2227,"width":1700,"height":47},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"024f5dcf0e054794ba40f8b16739e55e","type":"text","conversion_output":true,"text":"mediated dilation measurement will be mailed to Dr. Stein's laboratory and results will be returned to","text_display":" mediated dilation measurement will be mailed to Dr. Stein's laboratory and results will be returned to","confidence":1,"confidence_rate":1},{"cnt":[[120,2271],[1841,2271],[1841,2316],[120,2316]],"region":{"top_left_x":120,"top_left_y":2270,"width":1722,"height":47},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f3b308d07044dbe852f98ecaa2d0956","type":"text","conversion_output":true,"text":"Northwestern investigators. We have experience working with Dr. Stein in this capacity in our recently","text_display":" Northwestern investigators. We have experience working with Dr. Stein in this capacity in our recently","confidence":1,"confidence_rate":1},{"cnt":[[120,2316],[1992,2316],[1992,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2316,"width":1872,"height":46},"line":47,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b61856b3ecdc48789f182fe57c84e529","type":"text","conversion_output":true,"text":"completed randomized controlled trial of exercise in patients with PAD (44). Dr. Lu Tian, assistant professor in","text_display":" completed randomized controlled trial of exercise in patients with PAD (44). Dr. Lu Tian, assistant professor in","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1893,2359],[1893,2404],[120,2404]],"region":{"top_left_x":120,"top_left_y":2358,"width":1773,"height":47},"line":48,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ffea9cda1d14539bdedcc08752bb9a8","type":"text","conversion_output":true,"text":"the Department of Biostatistics at Stanford, will assist with statistical analyses. Dr. Tian was previously a","text_display":" the Department of Biostatistics at Stanford, will assist with statistical analyses. Dr. Tian was previously a","confidence":1,"confidence_rate":1},{"cnt":[[120,2402],[1886,2402],[1886,2447],[120,2447]],"region":{"top_left_x":120,"top_left_y":2401,"width":1767,"height":47},"line":49,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d5d29a4fb2a4453b6111e182b4013b5","type":"text","conversion_output":true,"text":"faculty member at Northwestern University and has worked with Dr. McDermott, Dr. Liu, and other study","text_display":" faculty member at Northwestern University and has worked with Dr. McDermott, Dr. Liu, and other study","confidence":1,"confidence_rate":1},{"cnt":[[120,2447],[1962,2447],[1962,2492],[120,2492]],"region":{"top_left_x":120,"top_left_y":2447,"width":1842,"height":46},"line":50,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8004351d065c47f995c29a3a3a0b6037","type":"text","conversion_output":true,"text":"investigators for more than five years. Drs. Michael H. Criqui (University of California at San Diego), Jack M.","text_display":" investigators for more than five years. Drs. Michael H. Criqui (University of California at San Diego), Jack M.","confidence":1,"confidence_rate":1},{"cnt":[[120,2492],[1927,2492],[1927,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2492,"width":1808,"height":46},"line":51,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d13dad68693847809a8502b1e729f3d0","type":"text","conversion_output":true,"text":"Guralnik (National Institute on Aging), and Luigi Ferrucci (National Institute on Aging) have worked with Dr.","text_display":" Guralnik (National Institute on Aging), and Luigi Ferrucci (National Institute on Aging) have worked with Dr.","confidence":1,"confidence_rate":1},{"cnt":[[120,2535],[1880,2535],[1880,2580],[120,2580]],"region":{"top_left_x":120,"top_left_y":2535,"width":1760,"height":46},"line":52,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0322379b56bb4b75be7a6d1a56d71903","type":"text","conversion_output":true,"text":"McDermott on PAD studies of functional impairment for over nine years and bring expertise in functional","text_display":" McDermott on PAD studies of functional impairment for over nine years and bring expertise in functional","confidence":1,"confidence_rate":1},{"cnt":[[1036,2582],[1089,2582],[1089,2628],[1036,2628]],"region":{"top_left_x":1035,"top_left_y":2582,"width":55,"height":46},"line":53,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9775daf87da64174b99652a14f7328af","type":"page_info","conversion_output":false,"text":"20","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"e63f6bd9-8a76-4101-acf6-184b5e738ce4-21","page":21,"lines":[{"cnt":[[354,30],[1772,30],[1772,75],[354,75]],"region":{"top_left_x":354,"top_left_y":30,"width":1419,"height":46},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e14bc789a3624d8db2bdb73f2138a594","type":"page_info","conversion_output":false,"text":"IRB \\#: STU00049675 Approved by NU IRB for use on or after 2/19/2018 through 2/18/2019.","text_display":"","confidence":0.9883100700224057,"confidence_rate":0.9998707908271756},{"cnt":[[1740,129],[2004,129],[2004,163],[1740,163]],"region":{"top_left_x":1740,"top_left_y":128,"width":265,"height":36},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2881eacabd3545e99897df5eef5c8d86","type":"page_info","conversion_output":false,"text":"Version 3.13.2017","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[120,206],[1949,206],[1949,251],[120,251]],"region":{"top_left_x":120,"top_left_y":206,"width":1829,"height":46},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"902bc9a07b9f4b6e917062f0088edead","type":"text","conversion_output":true,"text":"assessment, PAD, and clinical trials to the study team. Drs. Brian Annex and Doris Taylor bring expertise in","text_display":"\nassessment, PAD, and clinical trials to the study team. Drs. Brian Annex and Doris Taylor bring expertise in","confidence":1,"confidence_rate":1},{"cnt":[[122,249],[1678,249],[1678,299],[122,299]],"region":{"top_left_x":122,"top_left_y":249,"width":1556,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56fb53a3c51f4fbfa7a769904cb93ea0","type":"text","conversion_output":true,"text":"PAD, clinical trials, and/or progenitor cell measurement and interpretation to the study team.","text_display":" PAD, clinical trials, and/or progenitor cell measurement and interpretation to the study team.","confidence":1,"confidence_rate":1},{"cnt":[[122,339],[1927,339],[1927,385],[122,385]],"region":{"top_left_x":122,"top_left_y":339,"width":1806,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39fda2ac02ba40ffa9d51d4b974e0bf9","type":"text","conversion_output":true,"text":"E. Inclusion of Women/Minorities. PAD is common among older women and among African-Americans","text_display":"\nE. Inclusion of Women/Minorities. PAD is common among older women and among African-Americans","confidence":1,"confidence_rate":1},{"cnt":[[120,382],[1893,382],[1893,430],[120,430]],"region":{"top_left_x":120,"top_left_y":382,"width":1773,"height":48},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48ad4fd7b02641aebc66893bba06bf4f","type":"text","conversion_output":true,"text":"(102). We will ensure that our study population includes at least approximately \\(50 \\%\\) women and at least","text_display":" (102). We will ensure that our study population includes at least approximately \\(50 \\%\\) women and at least","confidence":1,"confidence_rate":1},{"cnt":[[120,425],[1944,425],[1944,475],[120,475]],"region":{"top_left_x":120,"top_left_y":425,"width":1825,"height":50},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18e991b0b2dc4b778d6ef435899cf792","type":"text","conversion_output":true,"text":"approximately \\(25 \\%\\) African-American (see enrollment table). We do not anticipate difficulty achieving these","text_display":" approximately \\(25 \\%\\) African-American (see enrollment table). We do not anticipate difficulty achieving these","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[120,471],[1981,471],[1981,518],[120,518]],"region":{"top_left_x":120,"top_left_y":470,"width":1861,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6cbd890253ab4ac5829a03eb5b1bb0a2","type":"text","conversion_output":true,"text":"recruitment targets, since our recently completed randomized controlled clinical trial of exercise in participants","text_display":" recruitment targets, since our recently completed randomized controlled clinical trial of exercise in participants","confidence":1,"confidence_rate":1},{"cnt":[[120,516],[1957,516],[1957,561],[120,561]],"region":{"top_left_x":120,"top_left_y":515,"width":1838,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87185a9f2f2a4332a5b5bc6d4de8312f","type":"text","conversion_output":true,"text":"with PAD included \\(52 \\%\\) women and \\(40 \\%\\) minorities ( 44 ). Our group has substantial experience successfully","text_display":" with PAD included \\(52 \\%\\) women and \\(40 \\%\\) minorities ( 44 ). Our group has substantial experience successfully","confidence":0.8642492294311523,"confidence_rate":0.998764373407615},{"cnt":[[120,559],[1936,559],[1936,604],[120,604]],"region":{"top_left_x":120,"top_left_y":558,"width":1816,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f652308fa9834c3ba76f2f4cad6c444c","type":"text","conversion_output":true,"text":"recruiting and enrolling women and minorities for our observational and clinical trial research in participants","text_display":" recruiting and enrolling women and minorities for our observational and clinical trial research in participants","confidence":1,"confidence_rate":1},{"cnt":[[120,602],[294,602],[294,642],[120,642]],"region":{"top_left_x":120,"top_left_y":601,"width":175,"height":42},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cdc9588d3fff4652bf693a91cdb80b61","type":"text","conversion_output":true,"text":"with PAD.","text_display":" with PAD.","confidence":1,"confidence_rate":1},{"cnt":[[120,690],[1927,690],[1927,737],[120,737]],"region":{"top_left_x":120,"top_left_y":689,"width":1808,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4a32d84622f43dbacbed5a73d521184","type":"text","conversion_output":true,"text":"Methods to ensure adequate enrollment of women and minorities. To ensure that we achieve a study","text_display":"\n\nMethods to ensure adequate enrollment of women and minorities. To ensure that we achieve a study","confidence":1,"confidence_rate":1},{"cnt":[[120,735],[1811,735],[1811,780],[120,780]],"region":{"top_left_x":120,"top_left_y":734,"width":1692,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"733c70a389584697932df535dd5cf7b2","type":"text","conversion_output":true,"text":"population that includes approximately \\(50 \\%\\) women and at least \\(25 \\%\\) minorities, we will make study","text_display":" population that includes approximately \\(50 \\%\\) women and at least \\(25 \\%\\) minorities, we will make study","confidence":1,"confidence_rate":1},{"cnt":[[120,778],[1955,778],[1955,827],[120,827]],"region":{"top_left_x":120,"top_left_y":777,"width":1836,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7f6fad96faa44aa88673471815aab29","type":"text","conversion_output":true,"text":"participation as simple and enjoyable as possible for women and minority participants. For example, we can","text_display":" participation as simple and enjoyable as possible for women and minority participants. For example, we can","confidence":0.994140625,"confidence_rate":0.9999470589826054},{"cnt":[[120,821],[1919,821],[1919,868],[120,868]],"region":{"top_left_x":120,"top_left_y":820,"width":1799,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4ae0d4777154436b0769a7a200dd5f0","type":"text","conversion_output":true,"text":"provide door-to-door transportation to study visits. We have also advertised our research opportunities on","text_display":" provide door-to-door transportation to study visits. We have also advertised our research opportunities on","confidence":1,"confidence_rate":1},{"cnt":[[120,864],[1927,864],[1927,913],[120,913]],"region":{"top_left_x":120,"top_left_y":863,"width":1808,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a7379dad623f42578ae4ab41661eac69","type":"text","conversion_output":true,"text":"radio or in newspapers for which the audience includes a high proportion of minority populations. If we still","text_display":" radio or in newspapers for which the audience includes a high proportion of minority populations. If we still","confidence":1,"confidence_rate":1},{"cnt":[[120,907],[1983,907],[1983,956],[120,956]],"region":{"top_left_x":120,"top_left_y":906,"width":1864,"height":51},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0c8f5b664f5a4b2992bf5b2d88c2bd75","type":"text","conversion_output":true,"text":"have difficulty recruiting significant proportions of minorities, we will enlist minority leaders in the community to","text_display":" have difficulty recruiting significant proportions of minorities, we will enlist minority leaders in the community to","confidence":1,"confidence_rate":1},{"cnt":[[120,954],[1970,954],[1970,999],[120,999]],"region":{"top_left_x":120,"top_left_y":953,"width":1851,"height":47},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"262368d8d4f34b74aaa143cd8d38ff1a","type":"text","conversion_output":true,"text":"assist with recruitment and we will make a substantial effort to hire an African-American research assistant to","text_display":" assist with recruitment and we will make a substantial effort to hire an African-American research assistant to","confidence":0.99853515625,"confidence_rate":0.9999873628584485},{"cnt":[[120,997],[569,997],[569,1040],[120,1040]],"region":{"top_left_x":120,"top_left_y":996,"width":450,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ef56c249ac9410da049966e79cf4948","type":"text","conversion_output":true,"text":"assist us with recruitment.","text_display":" assist us with recruitment.","confidence":1,"confidence_rate":1},{"cnt":[[120,1085],[1944,1085],[1944,1130],[120,1130]],"region":{"top_left_x":120,"top_left_y":1084,"width":1825,"height":47},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"528dd1927db542ee9a2de72f69d75ce4","type":"text","conversion_output":true,"text":"Alternatives should the above methods be insufficient. If the above methods are not sufficient, then we","text_display":"\n\nAlternatives should the above methods be insufficient. If the above methods are not sufficient, then we","confidence":1,"confidence_rate":1},{"cnt":[[120,1130],[1914,1130],[1914,1175],[120,1175]],"region":{"top_left_x":120,"top_left_y":1130,"width":1795,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23ef82957d3c499d98febf4136358da7","type":"text","conversion_output":true,"text":"will expand our recruitment of participants to hospitals in which the majority of patients are minorities. For","text_display":" will expand our recruitment of participants to hospitals in which the majority of patients are minorities. For","confidence":1,"confidence_rate":1},{"cnt":[[120,1173],[1852,1173],[1852,1218],[120,1218]],"region":{"top_left_x":120,"top_left_y":1173,"width":1732,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d10fbf6000774b64af6974643a19233b","type":"text","conversion_output":true,"text":"example, colleague and vascular surgeon Dr. Walter McCarthy is director of the non-invasive vascular","text_display":" example, colleague and vascular surgeon Dr. Walter McCarthy is director of the non-invasive vascular","confidence":1,"confidence_rate":1},{"cnt":[[120,1216],[1981,1216],[1981,1263],[120,1263]],"region":{"top_left_x":120,"top_left_y":1216,"width":1861,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee7c6fd9b4784161bf471421ab08bd2f","type":"text","conversion_output":true,"text":"laboratory at Cook County Hospital in Chicago. Similarly, colleague and vascular surgeon Dr. Melina Kibbe is","text_display":" laboratory at Cook County Hospital in Chicago. Similarly, colleague and vascular surgeon Dr. Melina Kibbe is","confidence":1,"confidence_rate":1},{"cnt":[[120,1259],[1910,1259],[1910,1306],[120,1306]],"region":{"top_left_x":120,"top_left_y":1258,"width":1790,"height":49},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"38a0cfc0c66f4ec0906b5778803609eb","type":"text","conversion_output":true,"text":"a vascular surgeon at the VA Chicago Medical Center. If necessary, we will work with Drs. McCarthy and","text_display":" a vascular surgeon at the VA Chicago Medical Center. If necessary, we will work with Drs. McCarthy and","confidence":1,"confidence_rate":1},{"cnt":[[120,1302],[1974,1302],[1974,1351],[120,1351]],"region":{"top_left_x":120,"top_left_y":1301,"width":1855,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc5d7dab1b6c475d9e187ed743687826","type":"text","conversion_output":true,"text":"Kibbe to identify additional participants from Cook County Hospital and VA Chicago, where many patients are","text_display":" Kibbe to identify additional participants from Cook County Hospital and VA Chicago, where many patients are","confidence":1,"confidence_rate":1},{"cnt":[[120,1349],[1968,1349],[1968,1394],[120,1394]],"region":{"top_left_x":120,"top_left_y":1349,"width":1848,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e500c54fca3e4eb98f2da2e43567d91a","type":"text","conversion_output":true,"text":"members of under-represented minority populations.F. Inclusion of Children. PAD does not affect children.","text_display":" members of under-represented minority populations.F. Inclusion of Children. PAD does not affect children.","confidence":1,"confidence_rate":1},{"cnt":[[120,1392],[1164,1392],[1164,1439],[120,1439]],"region":{"top_left_x":120,"top_left_y":1392,"width":1045,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffe3b88d5b144c7bb557c0bb0ff7a09e","type":"text","conversion_output":true,"text":"Therefore, children will not be included in the PROPEL study.","text_display":" Therefore, children will not be included in the PROPEL study.","confidence":1,"confidence_rate":1},{"cnt":[[116,1521],[501,1521],[501,1571],[116,1571]],"region":{"top_left_x":116,"top_left_y":1521,"width":385,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"011501abff4d4371a648c755c4f92edb","type":"section_header","conversion_output":false,"children_ids":["a4670e2d870b4758977b374344656137"],"text":"","text_display":""},{"cnt":[[120,1525],[496,1525],[496,1566],[120,1566]],"region":{"top_left_x":120,"top_left_y":1525,"width":377,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4670e2d870b4758977b374344656137","type":"text","conversion_output":true,"parent_id":"011501abff4d4371a648c755c4f92edb","text":"LITERATURE CITED","text_display":"\n\n\\section*{LITERATURE CITED}","confidence":1,"confidence_rate":1},{"cnt":[[122,1611],[1992,1611],[1992,1661],[122,1661]],"region":{"top_left_x":122,"top_left_y":1611,"width":1870,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2da5ff5cc6a145d68c02a5432ae43297","type":"text","conversion_output":true,"text":"1. Subramaniyam V, Waller EK, Murrow JR, Manatunga A, Lonial S, Kasirajan K, Sutcliffe D, Harris W, Taylor","text_display":"\n1. Subramaniyam V, Waller EK, Murrow JR, Manatunga A, Lonial S, Kasirajan K, Sutcliffe D, Harris W, Taylor","confidence":1,"confidence_rate":1},{"cnt":[[120,1659],[1966,1659],[1966,1704],[120,1704]],"region":{"top_left_x":120,"top_left_y":1658,"width":1846,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c0b65b89c7442d99da8195039529e79","type":"text","conversion_output":true,"text":"W, Alexander R. Bone marrow mobilization with granulocyte macrophage colony-stimulating factor improves","text_display":" W, Alexander R. Bone marrow mobilization with granulocyte macrophage colony-stimulating factor improves","confidence":0.77978515625,"confidence_rate":0.9976995312734868},{"cnt":[[120,1697],[1833,1697],[1833,1747],[120,1747]],"region":{"top_left_x":120,"top_left_y":1697,"width":1713,"height":50},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c832d09e7f514d2ab41c5413536b46d1","type":"text","conversion_output":true,"text":"endothelial dysfunction and exercise capacity in patients with peripheral arterial disease. Am Heart J","text_display":" endothelial dysfunction and exercise capacity in patients with peripheral arterial disease. Am Heart J","confidence":1,"confidence_rate":1},{"cnt":[[120,1745],[406,1745],[406,1790],[120,1790]],"region":{"top_left_x":120,"top_left_y":1744,"width":287,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a1290a4a14f64d179883d885b4e8491a","type":"text","conversion_output":true,"text":"2009;158:53-60.","text_display":" 2009;158:53-60.","confidence":1,"confidence_rate":1},{"cnt":[[120,1830],[1987,1830],[1987,1876],[120,1876]],"region":{"top_left_x":120,"top_left_y":1830,"width":1868,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc4b2ba007c74a26bcdb521e0c498cdf","type":"text","conversion_output":true,"text":"2. Sandri M, Adams V, Gielen S, Linke A, Lenk K, Kränkel N, Lenz D, Erbs S, Scheinert D, Mohr FW, Schuler","text_display":"\n2. 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Effects of exercise and ischemia on mobilization and functional activation of blood-derived","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,1919],[1760,1919],[1760,1966],[120,1966]],"region":{"top_left_x":120,"top_left_y":1918,"width":1640,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cec36f1fbe914f30a5e2cf419d51a19a","type":"text","conversion_output":true,"text":"progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation","text_display":" progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation","confidence":1,"confidence_rate":1},{"cnt":[[120,1964],[492,1964],[492,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1963,"width":372,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05bdbb5c0faa467f9927f9066af44ec5","type":"text","conversion_output":true,"text":"2005;111:3391-3399.","text_display":" 2005;111:3391-3399.","confidence":1,"confidence_rate":1},{"cnt":[[120,2050],[1884,2050],[1884,2099],[120,2099]],"region":{"top_left_x":120,"top_left_y":2049,"width":1765,"height":51},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"628f7a8e8fc74221be1462bb0086800b","type":"text","conversion_output":true,"text":"3. Van Royen N, Schirmer SH, Atasever B, Behrens CYH, Ubbink D, Buschmann EE, Voskuil M, Bot P,","text_display":"\n3. Van Royen N, Schirmer SH, Atasever B, Behrens CYH, Ubbink D, Buschmann EE, Voskuil M, Bot P,","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[120,2093],[1966,2093],[1966,2142],[120,2142]],"region":{"top_left_x":120,"top_left_y":2092,"width":1846,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a68172a0e6da4417890542724d186afe","type":"text","conversion_output":true,"text":"Hoefer I, Schlingemann RO, Biemond BJ, Tijssen JG, Bode C, Schaper W, Oskam J, Legemate DA, Piek JJ,","text_display":" Hoefer I, Schlingemann RO, Biemond BJ, Tijssen JG, Bode C, Schaper W, Oskam J, Legemate DA, Piek JJ,","confidence":1,"confidence_rate":1},{"cnt":[[120,2140],[2004,2140],[2004,2185],[120,2185]],"region":{"top_left_x":120,"top_left_y":2139,"width":1885,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ea7ec1e67f34c518fb95dab20a099ff","type":"text","conversion_output":true,"text":"Buschmann I. START Trial: A pilot study on Stimulation or ARTeriogenesis using subcutaneous application of","text_display":" Buschmann I. START Trial: A pilot study on Stimulation or ARTeriogenesis using subcutaneous application of","confidence":1,"confidence_rate":1},{"cnt":[[120,2183],[1824,2183],[1824,2232],[120,2232]],"region":{"top_left_x":120,"top_left_y":2182,"width":1705,"height":51},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff76baa61fa84213927deda96554541b","type":"text","conversion_output":true,"text":"granulocyte-macrophage colony stimulating factor as a new treatment for peripheral arterial disease.","text_display":" granulocyte-macrophage colony stimulating factor as a new treatment for peripheral arterial disease.","confidence":1,"confidence_rate":1},{"cnt":[[120,2226],[681,2226],[681,2271],[120,2271]],"region":{"top_left_x":120,"top_left_y":2225,"width":562,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1fc07674d2044fa8ce7348bc199ee19","type":"text","conversion_output":true,"text":"Circulation 2005;112:1040-1046.","text_display":" Circulation 2005;112:1040-1046.","confidence":1,"confidence_rate":1},{"cnt":[[120,2314],[1970,2314],[1970,2361],[120,2361]],"region":{"top_left_x":120,"top_left_y":2313,"width":1851,"height":49},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b9bc771749c40c3b348690ae7fa34d3","type":"text","conversion_output":true,"text":"4. Arai M, Misao Y, Nagai H, Kawasaki M, Nagashima K, Suzuki K, Tsuchiya K, Otsuka S, Uno Y, Takemura","text_display":"\n4. Arai M, Misao Y, Nagai H, Kawasaki M, Nagashima K, Suzuki K, Tsuchiya K, Otsuka S, Uno Y, Takemura","confidence":1,"confidence_rate":1},{"cnt":[[120,2359],[1996,2359],[1996,2406],[120,2406]],"region":{"top_left_x":120,"top_left_y":2358,"width":1876,"height":49},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08377791f8e4453ab53da6d22ba4beb8","type":"text","conversion_output":true,"text":"G, Nishigaki K, Minatoguchi S, Fujiwara H. Granulocyte colony-stimulating factor: A noninvasive regeneration","text_display":" G, Nishigaki K, Minatoguchi S, Fujiwara H. Granulocyte colony-stimulating factor: A noninvasive regeneration","confidence":0.99951171875,"confidence_rate":0.9999956778810385},{"cnt":[[120,2402],[1631,2402],[1631,2451],[120,2451]],"region":{"top_left_x":120,"top_left_y":2401,"width":1511,"height":51},"line":45,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a59915a40edb4e3883003db8e10ceb61","type":"text","conversion_output":true,"text":"therapy for treating atherosclerotic peripheral arterial disease. Circ J 2006;70:1093-1098.","text_display":" therapy for treating atherosclerotic peripheral arterial disease. Circ J 2006;70:1093-1098.","confidence":1,"confidence_rate":1},{"cnt":[[120,2488],[1848,2488],[1848,2537],[120,2537]],"region":{"top_left_x":120,"top_left_y":2487,"width":1728,"height":51},"line":46,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93b2bfc8dbb0484eb76582b540290054","type":"text","conversion_output":true,"text":"5. 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