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will be collected at Emory University/Children's Healthcare of Atlanta and the","text_display":"\n\nData will be collected at Emory University/Children's Healthcare of Atlanta and the","confidence":1,"confidence_rate":1},{"cnt":[[249,348],[1751,348],[1751,397],[249,397]],"region":{"top_left_x":249,"top_left_y":348,"width":1502,"height":50},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62f76aa82c2f4d4eb33150c5fb33bfb4","type":"text","conversion_output":true,"text":"University of California San Diego from July 2015 through July 2017. 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In cases of small expected cell counts,","text_display":" and Chi-square tests for categorical variables. In cases of small expected cell counts,","confidence":1,"confidence_rate":1},{"cnt":[[247,1401],[1867,1401],[1867,1450],[247,1450]],"region":{"top_left_x":247,"top_left_y":1400,"width":1620,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0e4ade11500485484009b9e1743ede9","type":"text","conversion_output":true,"text":"exact tests may be used in place of Chi-square tests. For reporting inferential statistical,","text_display":" exact tests may be used in place of Chi-square tests. For reporting inferential statistical,","confidence":1,"confidence_rate":1},{"cnt":[[245,1450],[1865,1450],[1865,1497],[245,1497]],"region":{"top_left_x":244,"top_left_y":1450,"width":1621,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c72205ebe60424ab46f2ee27d686649","type":"text","conversion_output":true,"text":"such as differences in means, 95 percent confidence interval will be used extensively to","text_display":" such as differences in means, 95 percent confidence interval will be used extensively to","confidence":1,"confidence_rate":1},{"cnt":[[245,1500],[956,1500],[956,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1499,"width":713,"height":51},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e57b6405ead4dc9a5a8385654d4f651","type":"text","conversion_output":true,"text":"quantify the degree of clinical efficacy.","text_display":" quantify the degree of clinical efficacy.","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1794,1594],[1794,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":1550,"height":50},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d86f7052a9134ec88396675650a81838","type":"text","conversion_output":true,"text":"The extent of missing data will be assessed using the methods described above. All","text_display":"\n\nThe extent of missing data will be assessed using the methods described above. All","confidence":1,"confidence_rate":1},{"cnt":[[247,1641],[1841,1641],[1841,1691],[247,1691]],"region":{"top_left_x":247,"top_left_y":1641,"width":1595,"height":50},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"39ae24331c184d97909fbff823ccb462","type":"text","conversion_output":true,"text":"missing data will be verified by querying sites for missing information. We will examine","text_display":" missing data will be verified by querying sites for missing information. 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Provided the","text_display":" pattern and time to dropout and missing values across treatment groups. Provided the","confidence":1,"confidence_rate":1},{"cnt":[[245,1788],[1811,1788],[1811,1835],[245,1835]],"region":{"top_left_x":244,"top_left_y":1787,"width":1568,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5d1ec11d80f48a3a63663625ab1bd74","type":"text","conversion_output":true,"text":"data are missing at random (MAR), a likelihood based approach to analysis (such as","text_display":" data are missing at random (MAR), a likelihood based approach to analysis (such as","confidence":1,"confidence_rate":1},{"cnt":[[245,1835],[1345,1835],[1345,1882],[245,1882]],"region":{"top_left_x":244,"top_left_y":1834,"width":1101,"height":49},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8614663f619847eeac78db2818da416a","type":"text","conversion_output":true,"text":"linear mixed models) will be utilized to handle missing data.","text_display":" linear mixed models) will be utilized to handle missing data.","confidence":1,"confidence_rate":1},{"cnt":[[247,1929],[1738,1929],[1738,1979],[247,1979]],"region":{"top_left_x":247,"top_left_y":1929,"width":1492,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db764b992dd7454eb22b6acda59504b1","type":"text","conversion_output":true,"text":"Prior to modeling, outcomes will be assessed for normality using histograms and","text_display":"\n\nPrior to modeling, outcomes will be assessed for normality using histograms and","confidence":1,"confidence_rate":1},{"cnt":[[247,1977],[1704,1977],[1704,2026],[247,2026]],"region":{"top_left_x":247,"top_left_y":1976,"width":1457,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a5f0dd3dc604901b5d3e0fdbb1f032e","type":"text","conversion_output":true,"text":"probability density plots. Data will be transformed prior to modeling to meet the","text_display":" probability density plots. Data will be transformed prior to modeling to meet the","confidence":1,"confidence_rate":1},{"cnt":[[247,2024],[1656,2024],[1656,2073],[247,2073]],"region":{"top_left_x":247,"top_left_y":2023,"width":1410,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"297e840576594f30962d12a49b75a71a","type":"text","conversion_output":true,"text":"assumption of normality. Residual plots by group will be inspected to assess","text_display":" assumption of normality. Residual plots by group will be inspected to assess","confidence":1,"confidence_rate":1},{"cnt":[[247,2073],[1691,2073],[1691,2121],[247,2121]],"region":{"top_left_x":247,"top_left_y":2073,"width":1444,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b3fe795b1ad4f43b60fa8e944a286f4","type":"text","conversion_output":true,"text":"heteroscedasticity. In cases where assumptions of normality are not met, log-","text_display":" heteroscedasticity. In cases where assumptions of normality are not met, log","confidence":1,"confidence_rate":1},{"cnt":[[245,2123],[1871,2123],[1871,2170],[245,2170]],"region":{"top_left_x":244,"top_left_y":2122,"width":1628,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b3974f3e2494ddaa9f545b8fd71cb39","type":"text","conversion_output":true,"text":"transformed variables or square-root transformed variables will be used in analysis, or a","text_display":"transformed variables or square-root transformed variables will be used in analysis, or a","confidence":1,"confidence_rate":1},{"cnt":[[245,2170],[1068,2170],[1068,2219],[245,2219]],"region":{"top_left_x":244,"top_left_y":2169,"width":824,"height":51},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc930012407e490abfd4ca31ddee3ab6","type":"text","conversion_output":true,"text":"non-parametric alternative will be employed.","text_display":" non-parametric alternative will be employed.","confidence":1,"confidence_rate":1},{"cnt":[[247,2264],[1796,2264],[1796,2314],[247,2314]],"region":{"top_left_x":247,"top_left_y":2264,"width":1550,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"433dd3f2631342e38fb054945eccd107","type":"text","conversion_output":true,"text":"Statistical analysis will be conducted using SAS v. 9.4 (Cary, NC) and all test will be","text_display":"\n\nStatistical analysis will be conducted using SAS v. 9.4 (Cary, NC) and all test will be","confidence":0.97998046875,"confidence_rate":0.999787152788203},{"cnt":[[245,2312],[1807,2312],[1807,2361],[245,2361]],"region":{"top_left_x":244,"top_left_y":2311,"width":1563,"height":51},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d53a5062085d417aa3036a5f59954f1c","type":"text","conversion_output":true,"text":"two-sided. Statistical significance will be assessed at the 0.05 level unless otherwise","text_display":" two-sided. 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Percent change in hepatic fat","text_display":" in the intervention group compared to the control group. Percent change in hepatic fat","confidence":1,"confidence_rate":1},{"cnt":[[245,397],[1807,397],[1807,445],[245,445]],"region":{"top_left_x":244,"top_left_y":397,"width":1563,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e598b5e1ba3a42c494b8d6bf41d63741","type":"text","conversion_output":true,"text":"will be compared between the two groups using two-sample t-tests or Wilcoxon-rank","text_display":" will be compared between the two groups using two-sample t-tests or Wilcoxon-rank","confidence":0.96875,"confidence_rate":0.9996308972245612},{"cnt":[[245,443],[1712,443],[1712,492],[245,492]],"region":{"top_left_x":244,"top_left_y":442,"width":1469,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5f2ddd00401433e9caadbc7b6984dba","type":"text","conversion_output":true,"text":"sum tests. The analysis will follow the intention to treat (ITT) principle, using all","text_display":" sum tests. The analysis will follow the intention to treat (ITT) principle, using all","confidence":1,"confidence_rate":1},{"cnt":[[245,492],[982,492],[982,544],[245,544]],"region":{"top_left_x":244,"top_left_y":491,"width":738,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8481808bb7dc41038d6d3695704998c2","type":"text","conversion_output":true,"text":"randomized participants in the analysis.","text_display":" randomized participants in the analysis.","confidence":1,"confidence_rate":1},{"cnt":[[243,632],[866,632],[866,690],[243,690]],"region":{"top_left_x":242,"top_left_y":631,"width":624,"height":59},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96f22ed74f524bb8ab8be8317f461cc5","type":"section_header","conversion_output":false,"children_ids":["0aefaf7bbb6d4bdab674e0e91206fcce"],"text":"","text_display":""},{"cnt":[[245,636],[862,636],[862,685],[245,685]],"region":{"top_left_x":244,"top_left_y":635,"width":618,"height":51},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0aefaf7bbb6d4bdab674e0e91206fcce","type":"text","conversion_output":true,"parent_id":"96f22ed74f524bb8ab8be8317f461cc5","text":"Secondary Outcome Measures","text_display":"\n\n\\section*{Secondary Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[245,683],[1865,683],[1865,733],[245,733]],"region":{"top_left_x":244,"top_left_y":683,"width":1621,"height":50},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4c339854c6d24327a8c024ae51dcb9ab","type":"text","conversion_output":true,"text":"To estimate the intervention effect for all primary, secondary and post-hoc analyses, we","text_display":"\n\nTo estimate the intervention effect for all primary, secondary and post-hoc analyses, we","confidence":0.99951171875,"confidence_rate":0.9999947483955305},{"cnt":[[245,730],[1682,730],[1682,780],[245,780]],"region":{"top_left_x":244,"top_left_y":730,"width":1439,"height":50},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b41547d159a94eaf9fd2388273e9caef","type":"text","conversion_output":true,"text":"will employ mixed models using baseline, week 4 , and week 8 measurements","text_display":" will employ mixed models using baseline, week 4 , and week 8 measurements","confidence":0.99853515625,"confidence_rate":0.9999825487512927},{"cnt":[[245,778],[1867,778],[1867,827],[245,827]],"region":{"top_left_x":244,"top_left_y":777,"width":1623,"height":51},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e02d7fecee64f95b24d74ab0447ae50","type":"text","conversion_output":true,"text":"conditioned on baseline values. This conditional joint response model is an extension to","text_display":" conditioned on baseline values. This conditional joint response model is an extension to","confidence":1,"confidence_rate":1},{"cnt":[[245,825],[1867,825],[1867,879],[245,879]],"region":{"top_left_x":244,"top_left_y":825,"width":1623,"height":54},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1359141b978a4859a29cce2d35c01462","type":"text","conversion_output":true,"text":"the traditional analysis of covariance model (ANCOVA), is more tolerant to missing data","text_display":" the traditional analysis of covariance model (ANCOVA), is more tolerant to missing data","confidence":1,"confidence_rate":1},{"cnt":[[245,924],[245,870],[1738,872],[1738,926]],"region":{"top_left_x":244,"top_left_y":870,"width":1495,"height":56},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9d70db4cd754f5fad5d05421010b3e4","type":"text","conversion_output":true,"text":"and is less biased than carrying forward baseline measurements. This modeling","text_display":" and is less biased than carrying forward baseline measurements. This modeling","confidence":1,"confidence_rate":1},{"cnt":[[245,922],[1800,922],[1800,973],[245,973]],"region":{"top_left_x":244,"top_left_y":921,"width":1557,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26eaa48a995c4f298ec8f8ef395751d7","type":"text","conversion_output":true,"text":"approach was chosen to adjust for possible differences between groups at baseline.","text_display":" approach was chosen to adjust for possible differences between groups at baseline.","confidence":0.9985356330871582,"confidence_rate":0.9999831560022533},{"cnt":[[245,971],[1863,971],[1863,1021],[245,1021]],"region":{"top_left_x":244,"top_left_y":971,"width":1619,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"109a6452b0fa44919fed6b06778bd664","type":"text","conversion_output":true,"text":"Models will be constructed using the PROC MIXED procedure in SAS. Standard errors","text_display":" Models will be constructed using the PROC MIXED procedure in SAS. Standard errors","confidence":1,"confidence_rate":1},{"cnt":[[245,1018],[1768,1018],[1768,1068],[245,1068]],"region":{"top_left_x":244,"top_left_y":1018,"width":1525,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"26d2925442e74d91b0c48e8414ec42c4","type":"text","conversion_output":true,"text":"will be estimated using an unstructured covariance matrix and the Kenward-Roger","text_display":" will be estimated using an unstructured covariance matrix and the Kenward-Roger","confidence":1,"confidence_rate":1},{"cnt":[[245,1066],[1807,1066],[1807,1117],[245,1117]],"region":{"top_left_x":244,"top_left_y":1065,"width":1563,"height":53},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6c4cc02b29f458d98263dc43f72254a","type":"text","conversion_output":true,"text":"method will be used to estimate the degrees of freedom for the fixed effects. 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Results","confidence":1,"confidence_rate":1},{"cnt":[[245,1113],[1863,1113],[1863,1164],[245,1164]],"region":{"top_left_x":244,"top_left_y":1112,"width":1619,"height":53},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f1261d33af84add9c973e0340ac37c1","type":"text","conversion_output":true,"text":"from these models will be presented as differences in group means at week 8, adjusted","text_display":" from these models will be presented as differences in group means at week 8, adjusted","confidence":1,"confidence_rate":1},{"cnt":[[245,1162],[1863,1162],[1863,1212],[245,1212]],"region":{"top_left_x":244,"top_left_y":1162,"width":1619,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fa66fa25f2740749041390563b3fe71","type":"text","conversion_output":true,"text":"for baseline, with associated \\(95 \\%\\) confidence intervals. All models will control for center","text_display":" for baseline, with associated \\(95 \\%\\) confidence intervals. All models will control for center","confidence":0.99072265625,"confidence_rate":0.999904895886626},{"cnt":[[245,1212],[556,1212],[556,1257],[245,1257]],"region":{"top_left_x":244,"top_left_y":1211,"width":313,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a69dfdb1f0e418fa2b0ba7a7f71feae","type":"text","conversion_output":true,"text":"as a fixed effect.","text_display":" as a fixed effect.","confidence":1,"confidence_rate":1},{"cnt":[[247,1306],[1837,1306],[1837,1356],[247,1356]],"region":{"top_left_x":247,"top_left_y":1306,"width":1590,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9c5ba15d7c8f485190bbad92c1039819","type":"text","conversion_output":true,"text":"For the sweetness perception testing, mean model estimates of sweetness perception","text_display":"\n\nFor the sweetness perception testing, mean model estimates of sweetness perception","confidence":1,"confidence_rate":1},{"cnt":[[245,1354],[1766,1354],[1766,1403],[245,1403]],"region":{"top_left_x":244,"top_left_y":1353,"width":1523,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13a46871f74f418fb90c2c9febd46644","type":"text","conversion_output":true,"text":"and pleasantness ratings at five different sucrose concentrations will be compared","text_display":" and pleasantness ratings at five different sucrose concentrations will be compared","confidence":1,"confidence_rate":1},{"cnt":[[245,1401],[1729,1401],[1729,1452],[245,1452]],"region":{"top_left_x":244,"top_left_y":1400,"width":1486,"height":53},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae322f98e3124bc7bf3b75ff9ec71d3d","type":"text","conversion_output":true,"text":"between study groups and visits using penalized B-splines due to the non-linear","text_display":" between study groups and visits using penalized B-splines due to the non-linear","confidence":1,"confidence_rate":1},{"cnt":[[245,1448],[1749,1448],[1749,1500],[245,1500]],"region":{"top_left_x":244,"top_left_y":1448,"width":1505,"height":52},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1a04dcc6ab5048a7b2a5ba79babfc388","type":"text","conversion_output":true,"text":"relationships between concentration and perceived sweetness and pleasantness.","text_display":" relationships between concentration and perceived sweetness and pleasantness.","confidence":1,"confidence_rate":1},{"cnt":[[245,1497],[1846,1497],[1846,1549],[245,1549]],"region":{"top_left_x":244,"top_left_y":1497,"width":1602,"height":53},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"999d1c4c960b46978739af18e917c526","type":"text","conversion_output":true,"text":"Patient specific random intercepts will be used to account for patient variation. Tukey's","text_display":" Patient specific random intercepts will be used to account for patient variation. Tukey's","confidence":1,"confidence_rate":1},{"cnt":[[245,1547],[1721,1547],[1721,1596],[245,1596]],"region":{"top_left_x":244,"top_left_y":1546,"width":1477,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57c2b1621fcd4fb1b357398bae1d92c3","type":"text","conversion_output":true,"text":"method will be used for adjustment for multiple comparisons. The concentration","text_display":" method will be used for adjustment for multiple comparisons. The concentration","confidence":1,"confidence_rate":1},{"cnt":[[245,1594],[1798,1594],[1798,1644],[245,1644]],"region":{"top_left_x":244,"top_left_y":1594,"width":1555,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"449d2a183fdb4371ad46f0c4a122d089","type":"text","conversion_output":true,"text":"associated with the highest pleasantness rating will be determined using a repeated","text_display":" associated with the highest pleasantness rating will be determined using a repeated","confidence":1,"confidence_rate":1},{"cnt":[[245,1641],[1188,1641],[1188,1693],[245,1693]],"region":{"top_left_x":244,"top_left_y":1641,"width":945,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b5bb0d9ccd4e4a8aa054e19ba34cdfc7","type":"text","conversion_output":true,"text":"measures ANOVA with a group by visit interaction.","text_display":" measures ANOVA with a group by visit interaction.","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]} |