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@@ -100,11 +100,10 @@ epidemiology. The dataset is designed for cross-sectional grading: predicting
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  DR stage from a fundus image, optionally conditioned on the limited information
101
  available at the point of grading. We document the construction, the grounding
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  literature, and a reproducible **distribution audit** that validates the
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- synthetic context against its source effect sizes. We are explicit about two
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- boundaries: the images are not African, and the clinical context is synthetic
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- and not patient-linked. The dataset is therefore a scaffold for building and
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- benchmarking grading pipelines and for teaching — **not** a source of clinical
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- or epidemiological findings.
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109
  ---
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@@ -120,18 +119,17 @@ hardware, and care-seeking behaviour. When such models are evaluated on African
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  populations they frequently degrade, a manifestation of dataset shift that is
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  both a scientific and an equity problem.
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- The **DR-Africa** family is an attempt to build infrastructure that takes this
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- gap seriously. Its first objective is a *multimodal* resource: DR research is
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- moving beyond the image alone toward models that combine retinal imaging with
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- systemic clinical variables (glycaemic control, diabetes duration, blood
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- pressure, renal function), because those variables are the true drivers of
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  incidence and progression. Real linked image–EHR cohorts from Africa are scarce,
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- so we bootstrap the pipeline with **epidemiology-grounded synthetic** clinical
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- data: synthetic records whose marginal distributions and conditional structure
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- are parameterised from published SSA cohort studies and meta-analyses.
132
 
133
  This repository, **DR-Grading**, is the entry point of the family and the
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- narrowest in scope by design (separation of concerns). It exposes only the
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  inputs realistically available *at the moment of grading* — the image plus three
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  context fields — and the grade label. The richer systemic record lives in
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  [`dr-progression`](../dr-progression); screening-prevalence evaluation lives in
@@ -155,8 +153,8 @@ proliferative DR (PDR). These map to the five source folders used here
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  **Existing DR image datasets.** EyePACS, APTOS 2019, Messidor / Messidor-2,
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  IDRiD, DDR, and DeepDRiD are the most widely used. They differ in grading
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- protocol, image quality, and population, and crucially for this work — none
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- ships paired structured clinical data, and none is African in origin.
160
 
161
  **Epidemiology of DR in Africa.** Pooled SSA estimates place any-DR prevalence
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  around 30–35% of people with diabetes and PDR at ~1% in population-based studies
@@ -323,8 +321,8 @@ about real African patients.
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  property of the generator, not evidence about patients.
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  3. **Referral-skewed labels.** The class balance reflects a clinic/referral
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  population, not screening; uncorrected accuracy overstates screening utility.
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- 4. **Minimal context by design.** Labs and comorbidities are intentionally absent
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- (they belong to `dr-progression`).
328
 
329
  ---
330
 
@@ -332,15 +330,14 @@ about real African patients.
332
 
333
  - **Synthetic data are flagged.** Every record carries `synthetic = True`. No
334
  attempt should be made to interpret a synthetic record as a real individual.
335
- - **Representation honesty.** Calling a dataset "Africa-grounded" while the
336
- imagery is non-African risks misrepresentation; we state the provenance
337
- prominently and treat the images strictly as a transfer-learning source.
338
- - **Data sovereignty.** The roadmap toward real African imaging and linked
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- records must be governed by local consent, ethics approval, and data-sovereignty
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- principles; this synthetic scaffold is explicitly a placeholder, not a substitute.
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- - **Intended benefit.** The resource exists to *amplify* DR research relevant to
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- Africa by lowering the barrier to multimodal experimentation, not to replace
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- real-world data collection.
344
 
345
  ---
346
 
 
100
  DR stage from a fundus image, optionally conditioned on the limited information
101
  available at the point of grading. We document the construction, the grounding
102
  literature, and a reproducible **distribution audit** that validates the
103
+ synthetic context against its source effect sizes. Two boundaries should be
104
+ clear: the images are not African, and the clinical context is synthetic and not
105
+ patient-linked. The dataset is meant for building and testing grading pipelines
106
+ and for teaching, not as a source of clinical or epidemiological findings.
 
107
 
108
  ---
109
 
 
119
  populations they frequently degrade, a manifestation of dataset shift that is
120
  both a scientific and an equity problem.
121
 
122
+ The **DR-Africa** family addresses this gap. Its first objective is a
123
+ *multimodal* resource: DR research is moving beyond the image alone toward models
124
+ that combine retinal imaging with systemic clinical variables (glycaemic control,
125
+ diabetes duration, blood pressure, renal function), which are the main drivers of
 
126
  incidence and progression. Real linked image–EHR cohorts from Africa are scarce,
127
+ so we start with **epidemiology-grounded synthetic** clinical data: synthetic
128
+ records whose marginal distributions and conditional structure are taken from
129
+ published SSA cohort studies and meta-analyses.
130
 
131
  This repository, **DR-Grading**, is the entry point of the family and the
132
+ narrowest in scope (separation of concerns). It exposes only the
133
  inputs realistically available *at the moment of grading* — the image plus three
134
  context fields — and the grade label. The richer systemic record lives in
135
  [`dr-progression`](../dr-progression); screening-prevalence evaluation lives in
 
153
 
154
  **Existing DR image datasets.** EyePACS, APTOS 2019, Messidor / Messidor-2,
155
  IDRiD, DDR, and DeepDRiD are the most widely used. They differ in grading
156
+ protocol, image quality, and population. None ships paired structured clinical
157
+ data, and none is African in origin.
158
 
159
  **Epidemiology of DR in Africa.** Pooled SSA estimates place any-DR prevalence
160
  around 30–35% of people with diabetes and PDR at ~1% in population-based studies
 
321
  property of the generator, not evidence about patients.
322
  3. **Referral-skewed labels.** The class balance reflects a clinic/referral
323
  population, not screening; uncorrected accuracy overstates screening utility.
324
+ 4. **Minimal context.** Labs and comorbidities are not included here (they belong
325
+ to `dr-progression`).
326
 
327
  ---
328
 
 
330
 
331
  - **Synthetic data are flagged.** Every record carries `synthetic = True`. No
332
  attempt should be made to interpret a synthetic record as a real individual.
333
+ - **Representation.** Calling a dataset "Africa-grounded" while the imagery is
334
+ non-African could mislead, so we state the provenance plainly and treat the
335
+ images only as a transfer-learning source.
336
+ - **Data sovereignty.** The move toward real African imaging and linked records
337
+ must follow local consent, ethics approval, and data-sovereignty principles.
338
+ This synthetic dataset is a placeholder, not a substitute.
339
+ - **Purpose.** The dataset exists to support DR research relevant to Africa by
340
+ making multimodal work easier to start, not to replace real-world data collection.
 
341
 
342
  ---
343