id large_stringlengths 16 16 | cell_context large_stringclasses 1
value | perturbation large_stringlengths 67 103 | predicted_delta large_stringlengths 372 518 | teacher_evidence_json large_stringclasses 1
value |
|---|---|---|---|---|
56163bf2c1fb3138 | CVCL_0023; A549; Lung; driver: ZFHX3 | 4EGI-1; dose/concentration: 0.05000000074505806; Protein synthesis inhibitor; inhibitor/antagonist | up: ENSG00000290421 (+5.89), ENSG00000261831 (+5.75), ENSG00000275106 (+5.43), ESR1 (+5.43), LINC01364 (+5.24), NAV2-AS2 (+5.24), BNC2-AS1 (+5.24), MYBPC3 (+5.24), ENSG00000231927 (+5.24), ENSG00000248994 (+5.24), ENSG00000260661 (+5.02), ROCK1P1 (+5.02); down: CTNS-AS1 (-4.61), DLL3 (-4.53), EGOT (-4.45), HAL (-4.37),... | |
ee3b6b253546868a | CVCL_0023; A549; Lung; driver: ZFHX3 | 9-ING-41; dose/concentration: 0.05000000074505806; GSK3 inhibitor; inhibitor/antagonist | up: ENSG00000289474 (+7.18), ENSG00000287737 (+5.56), PLEKHF1 (+5.44), ENSG00000239482 (+5.18), SLC30A8 (+5.03), KLRC4 (+4.86), LINC02696 (+4.86), C14orf39 (+4.86), ENSG00000289188 (+4.86), ENSG00000197550 (+4.86), ENSG00000289202 (+4.86), CHGA (+4.67); down: ENSG00000256100 (-4.86), FLNC (-4.25), RDUR (-4.25), GTF2IP5... | |
ada88f9ea8dcab68 | CVCL_0023; A549; Lung; driver: ZFHX3 | APTO-253; dose/concentration: 0.05000000074505806; unclear; unclear | up: ENSG00000246477 (+5.61), H2AC4 (+5.61), ENSG00000271670 (+5.61), ENSG00000269066 (+5.35), ENSG00000287377 (+5.34), ENSG00000233005 (+5.19), LINC02957 (+5.19), AHCTF1P1 (+5.06), ENSG00000259182 (+5.02), ENSG00000267316 (+5.02), LINC00299 (+4.97), TMEM200A (+4.83); down: LINC02877 (-4.55), LINC01671 (-4.28), MUC17 (-... | |
18e91770807823a9 | CVCL_0023; A549; Lung; driver: ZFHX3 | AT7519; dose/concentration: 0.05000000074505806; CDK inhibitor; inhibitor/antagonist | up: ENSG00000267059 (+5.39), ARHGEF2-AS1 (+5.24), DDO (+5.07), ENSG00000285919 (+5.07), SELENOP (+5.07), ENSG00000231557 (+5.07), ENSG00000286099 (+5.07), ENSG00000285941 (+4.88), SULT1A3 (+4.88), SIX2 (+4.87), THBS2-AS1 (+4.69), ENSG00000254730 (+4.65); down: FOXF2 (-4.60), MISP3 (-4.35), NAMPTP1 (-4.35), PTX3 (-4.29)... | |
c3be6d2f9f32abc9 | CVCL_0023; A549; Lung; driver: ZFHX3 | AZD1390; dose/concentration: 0.05000000074505806; unclear; inhibitor/antagonist | up: RN7SKP255 (+7.87), ENSG00000254519 (+5.50), COL6A6 (+5.24), CXCL13 (+5.24), H2AC17 (+5.08), ENSG00000230637 (+5.08), ENSG00000287368 (+5.08), ENSG00000248596 (+4.95), ENSG00000215835 (+4.91), ENSG00000285898 (+4.91), UCN (+4.91), PALM3 (+4.91); down: ENSG00000250820 (-4.89), LINC02877 (-4.80), ENSG00000266957 (-4.7... | |
ab72d532d46f1df6 | CVCL_0023; A549; Lung; driver: ZFHX3 | AZD2858; dose/concentration: 0.05000000074505806; GSK3 inhibitor; inhibitor/antagonist | up: RN7SKP255 (+8.44), ZFHX4-AS1 (+5.94), ENSG00000289393 (+5.72), SMPD3 (+5.46), RN7SL3 (+5.46), ENSG00000223576 (+5.45), RPS2P5 (+5.45), OR51I2 (+5.30), ENSG00000288907 (+5.13), ENSG00000285505 (+5.13), CERS1 (+4.98), GALNT8 (+4.94); down: H2AC20 (-6.02), ENSG00000289862 (-4.28), NICN1 (-4.28), ENSG00000286207 (-4.28... | |
a8632b4c91e47d39 | CVCL_0023; A549; Lung; driver: ZFHX3 | AZD-7648; dose/concentration: 0.05000000074505806; DNA synthesis/repair inhibitor; inhibitor/antagonist | up: RN7SKP255 (+6.21), ENSG00000289180 (+5.59), LRRC46 (+5.38), ENSG00000250129 (+5.38), FLG (+5.38), VXN (+5.38), IL12A (+5.27), ENSG00000266728 (+5.14), PTGES3P1 (+5.01), ENSG00000287330 (+5.01), GRAMD1A-AS1 (+4.85), PDCD6IPP1 (+4.85); down: ENSG00000234477 (-4.89), ACOXL (-4.84), NARF-AS2 (-4.68), RBP1 (-4.28), INTS... | |
fabb38424c31516f | CVCL_0023; A549; Lung; driver: ZFHX3 | AZD-8055; dose/concentration: 0.05000000074505806; MTOR inhibitor; inhibitor/antagonist | up: SPINK1 (+5.88), LINC00957 (+5.49), ZFHX4-AS1 (+5.11), SLC24A3 (+5.00), ENSG00000285961 (+4.96), SF1-DT (+4.96), LINC01610 (+4.96), IFNL2 (+4.83), ENSG00000256982 (+4.79), LINC01568 (+4.79), CLNK (+4.79), ENSG00000206549 (+4.79); down: ENSG00000265690 (-4.73), SP6 (-4.73), MUC2 (-4.68), CSTF3-DT (-4.62), GNA15-DT (-... | |
59c8198de93847ec | CVCL_0023; A549; Lung; driver: ZFHX3 | Abemaciclib; dose/concentration: 0.05000000074505806; CDK inhibitor; inhibitor/antagonist | up: ACOT4 (+8.62), WNT16 (+8.47), TMEM176A (+8.47), TSPOAP1 (+8.47), ITGAL (+8.47), CACNG3 (+8.47), CEACAM7 (+8.47), FMO1 (+8.47), DCN (+8.47), CD6 (+8.47), STMN4 (+8.47), CLCA1 (+8.47); down: PDE4D (-6.87), IGFBP3 (-5.48), PDE10A (-5.24), MT-ND5 (-5.21), KYNU (-4.90), PRKCA (-4.77), LDHA (-4.74), ARHGAP26 (-4.71), VIM... | |
a3bde6833a66fd10 | CVCL_0023; A549; Lung; driver: ZFHX3 | Adagrasib; dose/concentration: 0.05000000074505806; RAS inhibitor; inhibitor/antagonist | up: ENSG00000289180 (+5.93), ENSG00000289397 (+5.93), RN7SKP71 (+5.66), ENSG00000290285 (+5.52), RN7SKP255 (+5.52), KCND3 (+5.52), ENSG00000271980 (+5.35), ENSG00000288066 (+5.35), ENSG00000282080 (+5.35), ENSG00000285751 (+5.19), ACTN3 (+5.15), HOXD1 (+5.15); down: ZNF497 (-4.89), MEI1 (-4.23), LINC02877 (-4.18), BET1... | |
6d002a2acff9cd5d | CVCL_0023; A549; Lung; driver: ZFHX3 | Afatinib; dose/concentration: 0.05000000074505806; EGFR/ERBB inhibitor; inhibitor/antagonist | up: DENND2B-AS1 (+6.09), PELP1-DT (+5.36), MIR4307HG (+5.36), ENSG00000265399 (+5.36), ERVMER34-1 (+5.36), ENSG00000289188 (+5.36), ENSG00000287865 (+5.36), HIPK1-AS1 (+5.36), PAN3-AS1 (+5.36), ENSG00000269972 (+5.36), PLEKHF1 (+5.09), ENSG00000224610 (+5.09); down: PLXDC2 (-3.64), ENSG00000249111 (-3.64), UBA7 (-3.64)... | |
dfd6563bf31e472e | CVCL_0023; A549; Lung; driver: ZFHX3 | Alpelisib; dose/concentration: 0.05000000074505806; PI3K/AKT inhibitor; inhibitor/antagonist | up: RN7SKP255 (+8.31), ENSG00000260173 (+5.85), ENSG00000283390 (+5.48), APOBEC3G (+5.44), CCT5P1 (+5.44), FAM86B3P (+5.44), HCRT (+5.44), MIR3677HG (+5.44), LEP (+5.18), ENSG00000197550 (+5.18), ENSG00000228417 (+5.18), ENSG00000240440 (+5.18); down: NRG4 (-4.53), BTC (-4.45), LINC01409 (-4.22), EFCAB14-AS1 (-4.20), H... | |
8e6618b2c441a80d | CVCL_0023; A549; Lung; driver: ZFHX3 | Anastrozole; dose/concentration: 0.05000000074505806; unclear; inhibitor/antagonist | up: RN7SKP255 (+6.29), IFNL2 (+5.91), ENSG00000282936 (+5.78), ENSG00000255252 (+5.38), ENSG00000273154 (+5.29), ASB2 (+5.08), NPIPA7 (+5.08), WASH3P (+4.97), ENSG00000254680 (+4.84), KIRREL3-AS2 (+4.71), ENSG00000260823 (+4.71), ENSG00000289393 (+4.71); down: BTBD18 (-4.79), LDHAP4 (-4.79), ENSG00000237174 (-4.79), HS... | |
5c143b16df085eb2 | CVCL_0023; A549; Lung; driver: ZFHX3 | BAY1125976; dose/concentration: 0.05000000074505806; PI3K/AKT inhibitor; inhibitor/antagonist | up: RN7SKP255 (+6.01), SPEF1 (+5.30), ENSG00000286084 (+5.01), GFI1 (+5.01), OR2AG2 (+5.01), COL6A5 (+5.01), ENSG00000289511 (+5.01), ENSG00000289180 (+4.97), MIR3677HG (+4.84), CXCR2 (+4.84), PLPPR5-AS1 (+4.84), SPDYE16 (+4.84); down: RNU4-2 (-5.05), PLXNB3 (-4.78), TMEM44-AS2 (-4.73), LINC02877 (-4.73), PRRT1 (-4.33)... | |
d4f2bcd36fc253d2 | CVCL_0023; A549; Lung; driver: ZFHX3 | BI-78D3; dose/concentration: 0.05000000074505806; Other MAPK inhibitor; inhibitor/antagonist | up: ENSG00000288853 (+5.92), ENSG00000278936 (+5.77), ENSG00000235281 (+5.60), ENSG00000290067 (+5.41), TMEM114 (+5.41), ENSG00000250383 (+5.41), ENSG00000269947 (+5.41), ENSG00000282936 (+5.18), ENSG00000286780 (+5.18), ENSG00000289070 (+5.18), LINC03050 (+5.18), ENSG00000231724 (+5.18); down: SPTBN5 (-4.79), PNCK (-4... | |
2871f51bee8d4557 | CVCL_0023; A549; Lung; driver: ZFHX3 | BI-3406; dose/concentration: 0.05000000074505806; RAS inhibitor; inhibitor/antagonist | up: ARHGAP11B-DT (+5.59), ENSG00000282936 (+5.45), ENSG00000232633 (+5.30), ENSG00000269242 (+5.13), WFDC2 (+5.13), LINC02827 (+5.13), PPP1R21-DT (+5.13), BGLAP (+5.13), TMSB4XP6 (+5.13), ENSG00000215835 (+4.98), ENSG00000260277 (+4.98), LRTM1 (+4.94); down: LINC00589 (-4.34), THBS2 (-4.34), ZNF724 (-4.17), ENSG0000027... |
Tahoe Cell Perturbation Reasoning Subsets
Derived from tahoebio/Tahoe-100M.
This dataset contains two splits:
student
Barebones deterministic input for later small-LLM training:
idcell_contextperturbationpredicted_deltateacher_evidence_json— intentionally empty in this split because Hugging Face DatasetDict splits require matching schemas.
teacher
Same fields plus populated:
teacher_evidence_json
The teacher evidence contains drug metadata, cell-line metadata, sample metadata when available, and top differential-expression genes extracted from Tahoe's pseudobulk differential-expression table.
No AI-generated explanations are included yet.
Construction
Generated from tahoebio/Tahoe-100M config pseudobulk_differential_expression using pseudobulk differential-expression summaries.
Rows per split: 16
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