README.md

---
license: cc0-1.0
language:
  - en
tags:
  - neuroinflammation
  - depression
  - biomarkers
  - IL-6
  - TNF-alpha
  - CRP
  - mental-health
  - psychiatry
pretty_name: Neuroinflammation Biomarkers in Depression (2020-2024)
doi: 10.7910/DVN/QBQXKL
---

# Neuroinflammation Biomarkers in Depression (2020-2024)

[![DOI](https://img.shields.io/badge/DOI-10.7910%2FDVN%2FQBQXKL-blue)](https://doi.org/10.7910/DVN/QBQXKL) [![GitHub](https://img.shields.io/badge/GitHub-Code-black)](https://github.com/juanmoisesd/neuroinflammation-biomarkers-depression-2020-2024)

**Author:** Juan Moises de la Serna | ORCID: 0000-0002-8401-8018  
**Full dataset:** [Harvard Dataverse doi.org/10.7910/DVN/QBQXKL](https://doi.org/10.7910/DVN/QBQXKL)

## Description

Global meta-analysis of neuroinflammation biomarkers (IL-6, TNF-α, CRP, IL-1β) in depression (MDD), bipolar disorder (BD), and healthy controls. 147 studies, 15,000+ participants, 2020–2024.

| Biomarker | MDD | HC | Ratio |
|-----------|-----|-------|-------|
| IL-6 | 7.8 pg/mL | 2.4 pg/mL | 3.25× |
| TNF-α | 18.5 pg/mL | 8.2 pg/mL | 2.26× |
| CRP | 4.2 mg/L | 1.2 mg/L | 3.50× |

## Quick Start

```python
# pip install neuroinflammation-biomarkers-depression
from neuroinflammation_biomarkers import load_dataset, get_biomarker_summary
df = load_dataset()
summary = get_biomarker_summary()
```

## Citation
de la Serna, J.M. (2024). Neuroinflammation Biomarkers in Depression. Harvard Dataverse. https://doi.org/10.7910/DVN/QBQXKL