Correction: Pilot Feasibility Stud 8, 145 (2022)https://doi.org/10.1186/s40814-022-01091-3Following publication of the original article , the autDippel N, Zimmermann J, Brakemeier E-L, Christiansen H. Capturing impact messages in parent - child interactions: Adaption and Validation of the Impact-Message-Inventory. In preparation.The original article  has been


Arch Endocrinol Metab. 2022;66(1):132-3Where you read:Julio Alvarez Gamero1https://orcid.org/0000-0002-6861-5699Victor García Ruiz2https://orcid.org/0000-0002-6846-7630Jose Paz Ibarra3https://orcid.org/0000-0002-2851-3727Should read:Julio César Alvarez-Gamero1https://orcid.org/0000-0002-6861-5699Victor Raúl García-Ruiz2https://orcid.org/0000-0002-6846-7630Jose Luis Paz-Ibarra3https://orcid.org/0000-0002-2851-3727


Social PSYCHIATRY is essential for solutions of RH-conflicts leading to immense psychic&medical problems-. Millions tenants in Europe: Germany-54.3%/Austria-30.2%/France-25.3%/GB-24.1%/Italy-12.9%/Slovenia-4.5%. German journals reflect catastrophic situation of tenant-lessor conflicts-[3].REFERENCES: [1a]-Luetge,Ch et-al(ed): Experimental Ethics, Basingstoke:Palgrave-Macmillan,2014. [1b]-Pegoraro,R (Chancellor Academy/Vatican-City) «Arzt und Christ» 38:3-55,1992; EACME-2017-Barcelona AB:p.129-130. [2]-Michailov,M.Ch, Neu,E, Welscher,U et-al: [2a]-Psychology: EFPA-2019-Moscow AB:p.1529,1530,1549. IUPsyS-2008-Berlin Int.J.Psychol. 43/3-4 p.154,248,615,799. [2b]-Psychiatry: EPA-2020-virtual/Madrid, Eur.Psychiatry 63S:EPP0834/5+EPV0581/1470; EPA-2019-Warsaw 56S:S689; EPA-2018-Nice 48/S1:S623&567&662. WPA-2019-Lisbon, E-Poster WCP19-2137/-1822/-1839: 2018-Mexico-City, Abs.-Book WCP18-0584/-0625/-0643/-0654. 2011-Buenos-Aires, AB:PO1.200. [2c]-Philosophy&Law: IVR-2019-Lucerne Progr.Book:p.114-116. FISP-2018-Peking Abstr.Book(AB)1348-50,1373-4,1420; -2013-Athens AB464-5/503-4/766. EACME-2017-Barcelona/MedEthics) AB73-74/125-126. [2d]-Psychosomatics: ICPM-2017-Peking AB:ID: 648493/648895/647749/648878; -2005-Kobe, JPsychosomRes 58: 85-86. [2e]-Physiology: DPG-2019 (German-Austrian-Suisse Soc.) Acta-Physiol., 227/S719, A03-3,A03-4,A03-9,A04-4,A05-1. IUPS-2017-Rio-de-Janeiro, AB:ID977; IUPS-2009-Kyoto, J.Physiol.Sci. Proc-IUPS-Vol.XXII/Springer,p.249. [3]-German-journals-“tz”-München, 14.02.2019, 15.02.17, 06.12.16/p.10, 18.10.16/p.10. Süddt.Zeitung-no172/p.30, 2017. Bild-14.12.2018/p.12. Mü.-Merkur-14./15.12.2019/no289/p.33.Psychological-medical-social observations-.Complex interaction of social-natural factors (micro-ecology/apartments) are demonstrated by conflicts tenants-lessors (RH-Munich). Conflicts conc. high-rents, luxurious repair, cause dangerous psychoneurological diseases: anxiety-neurosis-insomnia-depression,etc., esp. in patients/seniors with cardio-vascular pathology. Defect-doors&radiators&windows (air-currents) induce respiratory-diseases, defect-illumination causes accidents . Examples for impossible situation in German-RH: After 47years annihilation of RH-contract (tenant-woman 74years); over 4.5years lessor tries to eliminate 2scientists from RH, living-working 40/50years  by justice-terror; RH-contracts of tenants 90years with dementia&blind-senior (90years) are annihilated. RH-conflict leads to lethal consequences of 73 year tenant-[3].SOCIAL PSYCHIATRY could help millions of tenants injured by RH-conflicts- by (a)-psychotherapy&education considering “total symptoms of mind-body, acc. to Emperor AKIHITO during ICPM-2005-Kobe-[2d], (b)-education of RH-administrators incl. philosophical/psychological/psychiatric-examination, (c)-foundation of „house-councils“ for „RH-industry“ counteracting psychopathological/-somatic diseases. This way will be supported UNO-Agenda21 for better health/education/ecology on global-level.No significant relationships.


Correction to: Orphanet Journal of Rare Diseases (2022) 17:406 10.1186/s13023-022-02282-0Following publication of the original article , we havehttps://www.gosh.nhs.uk/conditions-and-treatments/conditions-we-treat/severe-recessive-dystrophic-epidermolysis-bullosa-rdeb/55. Jessop N and Miller C (2020).


Graph embedding approaches have been attracting increasing attention in recent years mainly due to their universal applicability. They convert network data into a vector space in which the graph structural information and properties are maximumly preserved. Most existing approaches, however, ignore the rich information about interactions between nodes, i.e., edge attribute or edge type. Moreover, the learned embeddings suffer from a lack of explainability, and cannot be used to study the effects of typed structures in edge-attributed networks. In this paper, we introduce a framework to embed edge type information in graphlets and generate a Typed-Edge Graphlets Degree Vector (TyE-GDV). Additionally, we extend two combinatorial approaches, i.e., the colored graphlets and heterogeneous graphlets approaches to edge-attributed networks. Through applying the proposed method to a case study of chronic pain patients, we find that not only the network structure of a patient could indicate his/her perceived pain grade, but also certain social ties, such as those with friends, colleagues, and healthcare professionals, are more crucial in understanding the impact of chronic pain. Further, we demonstrate that in a node classification task, the edge-type encoded graphlets approaches outperform the traditional graphlet degree vector approach by a significant margin, and that TyE-GDV could achieve a competitive performance of the combinatorial approaches while being far more efficient in space requirements. Abstracting entities and their interactions as nodes and links, networks are a general model for studying complex systems . Real-woThese approaches, however, overlook rich information about interactions between nodes. Edge attribute or edge type information is indispensable when studying many networks. For instance, the label of each edge in a routing network reflects the cost of traffic via that edge and is used to determine the best possible routing scheme; in a user-object bipartite network, an edge is labelled with the user’s rating for the product, based on which effective recommender systems can be built ; and in To address this issue, we propose to incorporate edge type information into graphlets and form a Typed-Edge Graphlets Degree Vector (TyE-GDV) . This isWe then employ the proposed TyE-GDV and the classic graphlets degree vector  to evaluTo compare with the proposed method, we further extend two recent graphlets-based approaches, i.e., the colored graphlets approach  and the To summarise, the main contributions of this work are as follows:In order to effectively encode edge type information, we propose a novel framework to generate a Typed-Edge Graphlet Degree Vector;We further modify the TyE-GDV framework so that it is better suited for egocentric networks;We extend colored graphlets and heterogeneous graphlets approaches for edge-typed networks and egocentric networks.According to a case study on individuals with chronic pain, certain social ties are more crucial in understanding the effects of chronic pain and may result in more successful therapeutic interventions.We demonstrate that rich structural information enhanced by edge-type information leads to significant improvement in a typical machine learning task.The remainder of this paper is organised as follows. Related works are discussed in Section 2. Preliminary knowledge is provided in Section 3. The proposed typed-edge graphlets, and the extended colored graphlets and heterogeneous graphlets are introduced in Section 4 and Section 5, respectively. Experiments, results and analysis are presented in Section 6. Finally, we conclude and discuss future directions in Section 7.Compared to abundant approaches that take advantage of node attributes, fewer works have focused on leveraging edge attribute information in graph analysis. A straightforward approach is to construct an adjacency matrix containing edge attributes and then to factorise it . This apAlthough these approaches are shown to be effective in some downstream tasks, a common issue about them is that their learned embeddings lack explainability—we do not know what each element of the embedding vector means. They are, therefore, unable to reveal the deeper and, ideally, more easily explainable relationship between a local network structure and an edge attribute.In this section, we introduce the notions of graphlets and orbits, and discuss how they can be adapted in egocentric networks.Node degree, being the most basic structural feature, counts the number of edges incident to a node. Graphlets or graphlets degree generalises the idea of node degree by counting the number of graphlets the node participates. Specifically, graphlets are a set of “small connected nonisomorphic induced subgraphs” . Small iG7, for example, it touches orbit-0 three times (the degree of the node), orbit-2 once (the open triad), orbit-3 twice (the triangle), and orbit-13 once. Therefore, its graphlet degree vector has 3 at the 0th coordinate, 1s at the 2th and 13th coordinates, 2 at the 3rd coordinate, and 0s at the remaining coordinates.GDV, or sometimes normalised GDV, has been widely applied in various domains and has become a standard structural feature when measuring the similarities and differences between nodes –17. We sG1, but two node orbits in it. We also refer to edge orbits as edge-orbit graphlets in this work. The concept of heterogeneous graphlets is built upon edge orbits, and we will discuss more about it in Section 5.The notion of orbits was originally established at a node level, distinguishing a node position when counting graphlets. Hočevar and Demšar later proposed to count graphlets at a link level and introduced the notion of edge orbits . Fig 1 and G5 (4-cycle) are excluded because any node in them acting as an ego cannot reach other nodes in a single hop. Second, since only one node can serve as the ego in an egocentric graphlet, it is unnecessary to discriminate between different orbits. Therefore, there are in total seven egocentric graphlets of 2 to 4 nodes, which are 2-clique, 2-path, 3-clique, 3-star, tailed-triangle, 4-chordal-cycle and 4-clique . Additionally, the set of orbits o∈ ).The initial step of the framework is a graph preprocessing, where the set of edge types is mapped to integers ranging from 0 to  4 nodes . Thus, tAlgorithm 1: Build Typed-Edge Graphlet Degree Vector.input: preprocessed graph V′.Output: dictionary dic of vectors for all nodes ∈ V′.1 initialise: dic = {}2 foreachi ∈ V′ do3  initialise a 2d-vector vec of size 4  foreachdo5  Le = GetEdgeList(o);6  Upadate7 dic[i] = vec;Algorithm 2: Update Vector.1 Function Updateinput 2d-vector vec, type of node orbit o, list of edges eL. 2   foreache ∈ Ledo3   τe = GetType(e);o and τe are used as indices in vec.    */    /* 4   vec[o][τe] increase by 1;Algorithm 3: Code Snippet for Orbit-6, 9 and 10.V′ and for each orbit in the set of node-orbit graphlets pdate function (Algorithm 2). The calculation of each orbit in Algorithm 1 is omitted for a more concise expression. To demonstrate the detailed process, we give a program snippet for calculating orbit-6, orbit-9 and orbit-10 in Algorithm 3. C denotes all possible 2-combinations of the neighbours of node u. The use of combinations is to avoid repetitive calculation. In Algorithm 2, o and τe are readily used as indices when updating the vector as a result of the preprocessing stage. Finally, at the end of Algorithm 1, a dictionary of nodes as keys and their corresponding TyE-GDV as values is returned. For example, if an orbit-9 is detected and its four edges are of type ‘0’, ‘1’, ‘2’ and ‘2’, vector elements at coordinates , ,  and  will increase by 1. Obviously, the time complexity of generating TyE-GDV is the same as counting graphlets. Although the introduction and implementation of the typed-edge graphlets approach is aimed at dealing with edge attributed networks, it can be easily extended to node attributed networks by replacing an edge type with a node type, or to networks containing both different node and edge types by adding an extra dimension of a node type.Next, for any node of interest, the typed-edge graphlet degree vector (TyE-GDV), i.e., a two-dimensional vector of size C and C stand for all possible 2-combinations and 3-combinations of the neighbours of node i. Note that in TyE-EGDV, there are in total 7 orbits in As discussed in Section 3.2, egocentric networks are sometimes of special interest, especially when edge type information is included (as in our case study dataset of chronic pain patients). With the restriction of being egocentric, there are fewer orbits in graphlets that need to be considered. Therefore, we propose a tailor-made version of the framework for egocentric networks, called TyE-EGDV (see Algorithm 4). f 15 see . TherefoAlgorithm 4: Build Typed-Edge Ego-Graphlet Degree Vector.i with an edge type t, i.e., t that are connected to i. Then, a typed-edge degree vector (TyE-DV) can be defined as a vector containing typed-edge degrees of all types.Since a node degree is the simplest network structural metric, a naive way of encoding edge type information in a network structure is first to have the notion of a typed-edge degree. Formally, the typed-edge degree of a node Some other approaches that also aim to take a node and/or an edge type into consideration include the colored motifs , coloredT − 1, where T is the total number of possible node types. This is incorrect as it fails to take the size of the graphlet into account. When graphlet size is smaller than the number of node types, the total number of combinations will be smaller than 2T − 1. For example, when we consider the graphlet G0, i.e., 2-clique, with three possible node types, there are in total six combinations, instead of seven. The combination containing all three types cannot exist since there are only two nodes in this graphlet. Below, we give the amended equation for calculating the number of combinations in a given graphlet g:K(g) is the number of nodes of the graphlet when T refers to a node type, or the number of edges of the graphlet when it refers to an edge type. Note that when K(g)≥T, the equation becomes T − 1. We then develop a colored graphlets approach for edge-typed networks, named ColoredE-GDV, which is also applied to the case study in the next section.Colored graphlets approach  is at thThe recently proposed heterogeneous graphlets approach  also conK(g) is the number of nodes of the graphlet when T refers to a node type, and the number of edges when it refers to an edge type. Since type repetition is allowed in heterogeneous graphlets, the number of possible heterogeneous graphlets is larger than that of colored graphlets.Similarly, N . The approach of HeteroE-GDVN is demonstrated through Algorithm 5. We see clearly that its time complexity stays the same when counting untyped graphlets, but the space complexity grows fast with the number of edge types.In order to extend the idea of heterogeneous graphlets to a node-level analysis and to deal with typed edges, we propose a node-based typed-edge heterogeneous graphlets approach, named HeteroE-GDVAlgorithm 5: Node-based Heterogeneous Graphlets Degree Vector (Hetero-GDVN)input: preprocessed graph V′.output: dictionary dic of vectors for all nodes ∈V′.1 initialise: dic = {};2 /* range of edge number of graphlets of size 2—4 nodes       */3fork ← 1 to 6 do4  Lk =  increase by 1;13  14  dic[i] = vec;Although the above approaches seem powerful to capture all possible combinations (or combinations of repetitions) of different types of nodes or edges, their numbers of possible graphlets, which are also their space complexities, grow near-exponentially with the number of node or edge types. For example, with 9 node types, in the colored graphlets approach, there are 255 possible colored graphlets for a graphlet of 4 nodes; and in the heterogeneous graphlets approach, there are 495 possible graphlets. In comparison, the space complexity grows linearly with the number of edge types in the proposed TyE-GDV approach. Moreover, out of this large number of possible graphlets, only a tiny percentage of them actually exists in real networks. For example, in Cora citation network , only 19https://github.com/MingshanJia/explore-local-structure.In order to utilise the colored graphlets and the heterogeneous graphlets approaches in egocentric networks, we further develop their egocentric versions, and apply them in the chronic pain case study. With fewer node orbits to consider, egocentric colored graphlets and egocentric heterogeneous graphlets are faster and more space-saving than the original ones. The implementation of these algorithms is available at N and TyE-GDV share the same time complexity because they are all node-based algorithms. Hetero-GDVL as the only link-based algorithm, could be faster in sparse networks. When it comes to space complexity, the proposed TyE-GDV grows linearly with the number of edge types, while the other three methods grow near exponentially with it.To conclude this section, we summarise the time and space complexities of the four main approaches in In this section, we apply the proposed methods to analyse the egocentric social networks of chronic pain patients.The real-world dataset is collected from chronic pain patients of the League for Rheumatoid Arthritis, the League for Fibromyalgia and the Flemish Pain League . Each paSome basic characteristics of the egocentric networks, such as the ego nodes’ degree distribution and their edge-type distribution, are shown in Moreover, the grades of chronic pain are calculated by means of the Graded Chronic Pain Scale (GCPS), which evaluates both pain disability and pain intensity . Then, p®) Reviewers' comments:Reviewer's Responses to Questions  Comments to the Author1. Is the manuscript technically sound, and do the data support the conclusions?  The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: PartlyReviewer #2: Yes**********  2. Has the statistical analysis been performed appropriately and rigorously?   Reviewer #1: NoReviewer #2: Yes**********  3. Have the authors made all data underlying the findings in their manuscript fully available?PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.  The Reviewer #1: YesReviewer #2: No**********  4. Is the manuscript presented in an intelligible fashion and written in standard English?  PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.Reviewer #1: YesReviewer #2: Yes**********  5. Review Comments to the Author  Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. Reviewer #1: ID: PONE-D-22-15936Title: Encoding edge type information in graphletsSummary:In this work, a framework to embed edge type information in graphlets and generate a Typed-Edge Graphlets Degree Vector (TyE-GDV) is introduced.The manuscript is interesting; however, the following comment should be addressed :Abstract :- - - - - - - - - - -1 – The brief methodology should be given in the abstract .2 - The obtained results should be included in the abstract. The results should be included in terms of improvement ratio between the proposed and existing works .Introduction Section :- - - - - - - - - - - - - - - - - - - - - -3 – The structure of the manuscript need to be included at the end of this section .4 – A related work section should be included in the manuscript .Background and Preliminaries Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 – This section is fine . no comments .Typed-Edge Graphlet Degree Vector Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -6 – More justification is required in this section .Typed-Edge Degree, Colored Graphlets and 162 Heterogeneous Graphlets Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -7 – This section is fine . No comments .Experiments and Analysis Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - -8 – For more readability, more visual examples are requiredConclusion Section :- - - - - - - - - - - - - - - - - - - - - -8 – The limitation of this work should be clearly included in the conclusion section . Also, future work need to be included in this section .References :- - - - - - - - - - - - - -9 – References need to be updated from literature (2022) .- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Reviewer #2: The paper introduces Typed-Edge Graphlets Degree Vectors (TyE-GDV) as a tool to analyze egocentric networks with different edge types. The method is applied to pain patient data, both for analysis and for prediction of pain sensation from the patient's social network.The paper is well written and presents interesting ideas and results. I have a few minor comments:1. While the code is made available on GitHub, the data is not (at least not obviously to be found in the GitHub repository). For means of reproducibility it should be provided.2. Algorithm 3: The variables t_o_6, t_o_9 etc. used in the algorithm are not defined, neither in the algorithm nor in the text.3. Lines 135 and 137: It should read "from 0 to |T_e| - 1" and "from 0 to |O| - 1", respectively, to match the examples given within the same sentences.4. Line 160f: It would be helpful to add a reference to Fig. 2, which shows the 7 orbits of TyE-EGDV.5. Equations (1) and (2): The derivation of the formulae should be briefly explained, in particular since (1) is claimed to be a correction of a result previously published in [23].6. Fig. 4: The figure could be drawn as a radar chart, which might be more familiar to the usual reader than a parallel coordinates plot. The difference between the pain grades with respect to orbit types might also be more obvious in a radar chart. For Fig. 5 parallel coordinate plots are probably more appropriate due to the large number of attributes (edge types).7. References: Starting from ref. [17], page numbers are missing for most references. Also the formatting of reference entries varies, e.g., regarding the capitalization of journal titles. The whole reference section should be thoroughly proofread and amended where necessary.**********  6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.If you choose “no”, your identity will remain anonymous but your review may still be made public.Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.  Reviewer #1: NoYes: Volker AhlersReviewer #2: **********https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool,  22 Jul 2022Our detailed reponse is in the attached rebuttal letter.AttachmentRebuttal_Letter_PlosOne22.pdfSubmitted filename: Click here for additional data file. 2 Aug 2022
 PONE-D-22-15936R1

 Encoding edge type information in graphlets

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For instructions see: We look forward to receiving your revised manuscript.Kind regards,Lun HuAcademic EditorPLOS ONEJournal Requirements:Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.Additional Editor Comments:Although the quality of this work has been improved a lot after revision, one reviewer still has some minor concerns about the paper, please address them for publication.[Note: HTML markup is below. Please do not edit.]Reviewers' comments:Reviewer's Responses to Questions  Comments to the Author  1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.Reviewer #1: (No Response)Reviewer #2: All comments have been addressed**********  2. Is the manuscript technically sound, and do the data support the conclusions?  The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: YesReviewer #2: (No Response)**********  3. Has the statistical analysis been performed appropriately and rigorously?   Reviewer #1: YesReviewer #2: (No Response)**********  4. Have the authors made all data underlying the findings in their manuscript fully available?PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.  The Reviewer #1: YesReviewer #2: (No Response)**********  5. Is the manuscript presented in an intelligible fashion and written in standard English?  PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.Reviewer #1: YesReviewer #2: (No Response)**********  6. Review Comments to the Author  Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. Reviewer #1: ID: PONE-D-22-15936 R1Title: Encoding edge type information in graphletsSummary:In this work, a framework to embed edge type information in graphlets and generate a Typed-Edge Graphlets Degree Vector (TyE-GDV) is introduced.The authors have addressed the raised comments; however, one comment need to be addressed. Please check the comments below :Abstract :- - - - - - - - - - -1 – The abstract is fine. No comments .Introduction Section :- - - - - - - - - - - - - - - - - - - - - -2 – This section is fine. No comments .Preliminaries Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -3 – This section is fine . no comments .Typed-Edge Graphlet Degree Vector Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -4 – This section is fine . no comments .Typed-Edge Degree, Colored Graphlets and 162 Heterogeneous Graphlets Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 – This section is fine . No comments .Experiments and Analysis Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - -6 – This section is fine . No comments .Related Work Section :- - - - - - - - - - - - - - - - - - - - - - - - - - - -7 – This section need to be moved after the Introduction Section .Conclusion Section :- - - - - - - - - - - - - - - - - - - - - -8 – This section is fine . 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NORTH AMERICA29 September – 1 October, 2022Society of Vascular Medicine (SVM) 33rd Annual Scientific SessionsGrand Hyatt Denver, Denver, Colorado USAwww.woundsource.com/resource/svm-33rd-annual-scientific-sessions14‐16 October 2022Symposium on Advanced Wound Care Fall 2022 Las Vegas, NV. USAwww.sawcfall.com14‐16 October 2022Wounds CanadaSheraton Centre Hotel, Toronto Canadawww.woundscanada2022.ca13‐16 October 2022American Vein and Lymphatic Society Annual CongressNew Orleans, Louisiana, USAwww.myavls.org/annual-congress-202210‐12 November 2022Association for the Advancement of Wound CareSalt Lake City, Utah USAwww.aawconline.org/2022-annual-conferenceEUROPE4 October, 2022International Conference on Wound Care Management (ICWCM)Baku, Azerbaijanwww.conferenceindex.org/event/international-conference-on-wound-care-management-icwcm-2022-october-baku-az28‐29 October 2022International Conference on Biomaterials in Drug Delivery and Wound Care ICBDDWCLisbon, Portugalwww.waset.org/biomaterials-in-drug-delivery-and-wound-care-conference-in-october-2022-in-lisbon8‐9 November 2022International Conference on Textile Materials for Wound Care ICTMWCIstanbul, Turkeywww.waset.org/textile-materials-for-wound-care-conference-in-november-2022-in-istanbul18‐19 November 2022International Conference on Smart Textiles for Wound Care ICSTWCLondon, United Kingdomwww.waset.org/smart-textiles-for-wound-care-conference-in-november-2022-in-london24‐27 November 202216th National and 4th International Wound CongressAntalya, Turkeywww.yarakongresi2022.org/en/home-fourteen-english7 December, 2022Israel Wounds Ostomy and Incontinence Association (IWOIA)Tel Aviv, Israelwww.facebook.com/groups/1618684384988994INTERNATIONAL5‐6 December 2022International Conference on Wound Care, Tissue Repair and Regenerative MedicineDubai, United Arab Emirateswww.woundcare.alliedacademies.com


Jon Pines FRSEditor-in-Chief, Open Biology


Psychiatry is fundamental interdisciplinary medical science with essential importance for enormous health-problems of humanity. Creation of integrative-psychiary in context of multidimensional&holistic medicine, founded by HIPPOCRATES-GALENUS-HUA T’UA-AVICENA-PARACELSUS is necessary to counteract disastrous human health-situation. Psychiatry needs new integrative therapy-models considering application of psychopharmacotherapy as well as practices of psycho-somatic (Th.v.UEXKÜLL) and somato-psychic theories (Y.IKEMI). Emperor AKIHITO during Opening-Ceremony of ICPM-2005-Kobe appointed to consider “total symptoms of mind-body, seeking ways of holistic care”.REFERENCES. PSYCHIATRY: EPA-2020-virtual/Madrid, Eur.Psychiatry 63S, EPP0834/5+EPV0581/1470; EPA-2019-Warsaw, Eur. Psychiatry 56S,S689; EPA-2018-Nice, Eur.Psychiatry 48/S1, S623&567&662. WPA-2019-Lisbon, E-Poster WCP19-2137, -1822, -1839; 2018-Mexico-City, Abs.-Book WCP18-0584/-0625/-0643/-0654. 2011-Buenos-Aires,AB:PO1.200. PSYCHOLOGY: EFPA-2019-Moscow, Abs.-Book 1529,1530,1549. IUPsyS-2012-Cape-Town, IntJPsychol 47:407; -2008-Berlin, 43/3-4:154, 248,615,799; -2004-Beijing, AB:49,587. PSYCHOSOMATICS: ICPM-2017-Beijing, AB:ID: 648493,648895,648749,648878; -2005-Kobe, J.Psychosom.Res. 58:85-86.Evaluation of psychic-“polar-attitude-list”/physiological-parameters: heart-rate, blood-pressure,etc. from patients/probands after training by occidental/oriental practices (Music-/Yogatherapy/others) (ref.).Observations demonstrate strong positive influence after music[1], respiratory[2], hatha-yoga[3] therapies. Items of psycho-physiological (relaxed), emotional (tranquil/happy), cognitive (few/ordered thoughts), voluntary (active/spontaneous), social (open/assertive), consciousness (clear/sleepy) categories are significantly positive changed 25-50%. The 3-therapies have specific psychic-effects,e.g. items “relaxed/tranquil” after respiratory- (+45/50%) and music- (+20/5%), also item “open” after music-therapy (+25%) are positive, but negative after respiratory-therapy (-20%). Psychic-effects are correlated with positive physiological-ones,e.g. heart/respiratory-frequency decreased 25-30%, voluntary-apnoea prolonged 55%. Mountain-altitude (>2000-3000m), hypothermia (<20 to 0°C) influenced positively psychic/physiological-parameters,e.g. heart-rate/blood-pressure decrease .Different methods of integrative psychiatric therapy are with preference,e.g. for depression is suitable respiratory/physical-training, also hypothermia&high-mountain therapy (activation-euphoria), for mania:music-therapy (inhibitory-effect). Systematically research about single/combined therapies is necessary,e.g. for epilepsy: Respiratory-therapy/hypothermia,etc. could help patients (hypo-/hypercapnia: inhibitory/excitatory effects on CNS-structures).


Artificial intelligence, machine learning, computer-aided diagnosis,and radiomics: advances in imaging towards to precision medicine, DOI:http://dx.doi.org/10.1590/0100-3984.2019.0049, published inRadiologia Brasileira, 52(6):387-396, on page 387, line 7:In the article where it reads:Marcello Henrique Nogueira Barbosashould read:Marcello Henrique Nogueira-BarbosaProf. Dr. Edson MarchioriRadiologia BrasileiraEditor-in-Chief of


Trechispora are an important genus of wood-inhabiting fungi that have the ability to decompose rotten wood in the forest ecosystem. In this study, we reported three new species of Trechispora: T. murina, T. odontioidea, T. olivacea from a subtropical region of Yunnan Province, China. Species descriptions were based on a combination of morphological features and phylogenetic analyses of the ITS and LSU region of nuclear ribosomal DNA. Trechispora murina is characterized by the resupinate basidiomata, grandinioid hymenial surface with a greyish tint, monomitic hyphal system and ellipsoid, thick-walled, ornamented basidiospores; T. odontioidea has an odontioid hymenial surface with cylindrical to conical, blunt aculei and subglobose to globose, colorless, slightly thick-walled, ornamented basidiospores; T. olivacea has a farinaceous hymenial surface with olivaceous tint, basidia clavate and thick-walled, ornamented, broadly ellipsoid to globose basidiospores. Sequences of the ITS and nLSU rDNA markers of the studied samples were generated, and phylogenetic analyses were performed with maximum likelihood, maximum parsimony, and Bayesian inference methods. After a series of phylogenetic analyses, the 5.8S+nLSU dataset was constructed to test the phylogenetic relationship of Trechispora with other genera of Hydnodontaceae. The ITS dataset was used to evaluate the phylogenetic relationship of the three new species with other species of Trechispora. Using ITS phylogeny, the new species T. murina was retrieved as a sister to T. bambusicola with moderate supports; T. odontioidea formed a single lineage and then grouped with T. fimbriata and T. nivea; while T. olivacea formed a monophyletic lineage with T. farinacea, T. hondurensis, and T. mollis. Trechispora P. Karst. belongs to Trechisporales, a small but strongly supported order in Agaricomycotina [Trechispora (Hydnodontaceae Jülich) typified by T. onusta P. Karst., which is characterized by resupinate to effused basidiomata; a smooth to hydnoid to poroid hymenophore; ampullaceous septa; short cylindric basidia; and smooth to verrucose or aculeate basidiospores [Trechispora. About 60 species are currently accepted in Trechispora worldwide [Fungi form an essential branch of the tree of life, inferred from the important relationship with animals and plants , and it mycotina ,15. Treciospores . Currentorldwide ,25,26,27orldwide ,32,33,34Trechispora nested into trechisporoid clade [Trechispora belonged to Hydnodontaceae and was related to genera Brevicellicium K.H. Larss. & Hjortstam, Porpomyces Jülich, Sistotremastrum J. Erikss., and Subulicystidium Parmasto [Trechispora to these genera are basidiomata resupinate, hyphal system monomitic, cystidia absent [Porpomyces, Scytinopogon Singer, and Trechispora grouped closely together and nested within Hydnodontaceae [The high phylogenetic diversity on the corticioid Agaricomycetes based on two genes, 5.8S and 28S in which nine taxa of id clade . The molParmasto , the sima absent . The phyontaceae .Trechispora reports two new Trechispora species: T. cyatheae Ordynets, Langer & K.H. Larss. and T. echinocristallina Ordynets, Langer & K.H. Larss., which were found in La Réunion Island [Trechispora has been reported from North America and China [Based on the ITS and nLSU datasets, the phylogenetic study of n Island . Recentlnd China ,33,34.Trechispora.During the investigations of the corticioid fungi, Yunnan Province, China, we collected three fungal taxa, which could not be assigned to any described species within Hydnodontaceae. We present morphological and molecular phylogenetic evidence that support them as the three new species in Fresh fruiting bodies of the fungi growing on fallen angiosperm branches were collected in 2019 from the Honghe and Wenshan of Yunnan Province, China. The samples were photographed in situ and macroscopic details were recorded. Field photographs were taken by a Jianeng 80D camera . All photographs were focus-stacked and merged using Helicon Focus Pro 7.7.5 software. Once the macroscopic details were recorded, the specimens were transported to a field station where the specimens were dried on an electronic food dryer at 45 °C. Once dried, the specimens were labeled and sealed in envelopes and plastic bags. The dried specimens were deposited in the herbarium of the Southwest Forestry University (SWFC), Kunming, Yunnan Province, China.The macromorphological descriptions were based on field notes and photos captured in the field and laboratory. Color, texture, taste and odor of fruit bodies were mostly based on the authors’ field trip investigations. Color terminology follows Kornerup and Wanscher . All mathttp://lutzonilab.org/nuclear-ribosomal-dna/, accessed on 7 June 2019). The PCR procedure used for ITS was as follows: initial denaturation at 95 °C for 3 min, followed by 35 cycles at 94 °C for 40 s, 58 °C for 45 s, and 72 °C for 1 min, and a final extension of 72 °C for 10 min. The PCR procedure used for nLSU was as follows: initial denaturation at 94 °C for 1 min, followed by 35 cycles at 94 °C for 30 s, 48 °C for 1 min, and 72 °C for 1.5 min, and a final extension of 72 °C for 10 min. The PCR products were purified and sequenced at Kunming Tsingke Biological Technology Limited Company . All the newly generated sequences were deposited in NCBI GenBank   was used to obtain genomic DNA from the dried specimens following the manufacturer’s instructions . The nucer 2021) .Trechispora and related genera, and the ITS dataset was used to evaluate the phylogenetic relationships of the new species with known species of the genus. Sequences of Porpomyces mucidus (Pers.) that Jülich and P. submucidus F. Wu & C.L. Zhao retrieved from GenBank were used as the outgroup for the 5.8S+nLSU analysis  Hjortstam & Ryvarden retrieved from GenBank were used as the outgroup for the ITS analysis , maximum likelihood (ML), and Bayesian inference (BI), according to Zhao and Wu . MaximumMrModeltest 2.3  was usedThe 5.8S+nLSU dataset  includedBrevicellicium, Dextrinocystis Gilb. & M. Blackw., Litschauerella Oberw., Luellia K.H. Larss. & Hjortstam, Scytinopogon, Sistotremastrum J. Erikss., Sphaerobasidium Oberw., Subulicystidium Parmasto, Tubulicium Oberw., and Trechispora, shows that all related genera cluster into Trechisporales and the three new species grouped into Trechispora.The 5.8S+nLSU rDNA gene regions  include The ITS-alone dataset  includedTrechispora, in which the new species T. murina was sister to T. bambusicola with higher supports ; T. odontioidea formed a unique position within the clade of T. fimbriata C.L. Zhao and T. nivea (Pers.) K.H. Larss; while T. olivacea shared a clade formed by the members of T. farinacea (Pers.) Liberta, T. hondurensis Schoutteten & Haelew., and T. mollis.The phylogram inferred from the ITS dataset  indicateTrechispora murina K.Y. Luo & C.L. Zhao, sp. nov. MycoBank no.: 842491.Holotype—China, Yunnan Province, Wenshan, Funing County, Guying Village, GPS coordinates 23°44′ N, 105°56′ E, altitude 750 m asl., on a fallen angiosperm branch, leg. C.L. Zhao, 20 January 2019, CLZhao 11752 (SWFC).Etymology—murina (Lat.): Referring to the furry mouse-like hymenial surface.Basidiomata—Annual, resupinate, thin, growing adnate but easily separable, up to 15 cm long, 3 cm wide, 100–500 µm thick. Hymenial surface grandinioid, pale greyish to grey when fresh, turn to greyish upon drying. Sterile margin concolorous with a hymenial surface, up to 2 mm wide.Hyphal system—Monomitic; generative hyphae with clamp connections; colorless; thick-walled with a wide to lumen; richly branched; interwoven; encrusted; 2–3.5 µm in diameter; IKI–, CB–; tissues unchanged in KOH.Hymenium—Cystidia and cystidioles absent; basidia more or less clavate, with four sterigmata and a basal clamp connection, 10.0–14.0 × 3.5–4.5 µm; basidioles dominant; basidioles in shape similar to basidia, but slightly smaller.Spores—Basidiospores ellipsoid, colorless, thick-walled, ornamented, IKI–, CB–, (2.5–) 3–4 × (2–) 2.5–3 µm, L = 3.42 µm, W = 2.87 µm, Q = 1.17–1.20 (n = 60/2).Additional specimen examined (paratype)—China, Yunnan Province, Wenshan, Funing County, Guying Village, GPS coordinates 23°39′ N, 105°59′ E, altitude 1400 m asl., on a fallen angiosperm branch, leg. C.L. Zhao, 20 January 2019, CLZhao 11736 (SWFC).Trechispora odontioidea K.Y. Luo & C.L. Zhao, sp. nov. MycoBank no.: 844493.Holotype—China, Yunnan Province, Honghe, Pingbian County, Daweishan National Nature Reserve. GPS coordinates: 23°420′ N, 103°300′ E; altitude: 1500 m asl., on fallen angiosperm branches, leg. C.L. Zhao, 1 August 2019, CLZhao 17890 (SWFC).odontioideaEtymology— (Lat.): Referring to the odontioid hymenophore.Basidiomata—Annual, adnate, thin, up to 11 cm long, 2.5 cm wide, 50–200 µm thick. Hymenial surface odontioid, aculei cylindrical to conical, blunt, 0.3–0.6 mm long, pale buff when fresh, turn to buff upon drying. Sterile margin indistinct, cream to buff, 0.5–1 mm wide.Hyphal system—Monomitic; generative hyphae with clamp connections; colorless, thin- to thick-walled; frequently branched; interwoven; 2–3.5 µm in diameter; ampullate hyphae frequently present; IKI−, CB−; tissues unchanged in KOH.Hymenium—Cystidia and cystidioles absent.; basidia clavate, with four sterigmata and a basal clamp connection, 8.0–12.0 × 2.5–4 µm; basidioles dominant, in shape similar to basidia, but smaller.Spores—Basidiospores subglobose to globose, colorless, slightly thick-walled, ornamented, IKI−, CB−, 2–3 × 1.5–2.5 µm, L = 2.53 µm, W = 2.00 µm, Q = 1.27 (n = 30/1).Trechispora olivacea K.Y. Luo & C.L. Zhao, sp. nov. MycoBank no.: 844494.Holotype—China, Yunnan Province, Honghe, Pingbian County, Daweishan National Nature Reserve. GPS coordinates: 23°420′ N, 103°300′ E; altitude: 1500 m asl., on fallen angiosperm branches, leg. C.L. Zhao, 1 August 2019, CLZhao 17826 (SWFC).Etymologyolivacea— (Lat.): Referring to the olivaceous hymenial surface.Basidiomata—Annual, resupinate, thin, very hard to separate from substrate, up to 11 cm long, 2.5 cm wide, 30–80 µm thick. Hymenial surface farinaceous, pale white to slightly olivaceous when fresh, turn to olivaceous upon drying. Sterile margin indistinct, slightly olivaceous, 0.2–0.5 mm wide.Hyphal system—Monomitic; generative hyphae with clamp connections; colorless; thin- to thick-walled; occasionally branched; interwoven; 1.5–3.0 µm in diameter; ampullate hyphae present; IKI–, CB–; tissues unchanged in KOH.Hymenium—Cystidia and cystidioles absent; basidia clavate, with four sterigmata and a basal clamp connection, 10.0–12.0 × 4.5–5 µm; basidioles dominant, with the shape similar to basidia, but smaller.Spores—Basidiospores broadly ellipsoid to globose, colorless, thick-walled, ornamented, IKI–, CB–, 2.5–4 × 1.5–2.5 µm, L = 3.30 µm, W = 2.65 µm, Q = 1.25 (n = 30/1).Trechispora farinacea and T. hymenocystis nested into Trechispora located in Hydnodontaceae  [Trechispora murina, T. odontioidea, and T. olivacea are nested into Trechispora, in which T. murina was sister to T. bambusicola; T. odontioidea formed a monophyletic lineage and then grouped with T. fimbriata and T. nivea; while T. olivacea formed a monophyletic lineage and then grouped with T. farinacea, T. hondurensis, and T. mollis. However, T. bambusicola is morphologically distinguishable from T. murina by having the odontioid hymenophore with cream to buff the hymenial surface [Trechispora fimbriata is distinguishable from T. odontioidea by having the hydnoid hymenial surface and longer basidiospores (3–3.6 × 2.4–3.2 µm) [T. nivea differs from T. odontioidea by its thin-walled, larger basidiospores (3.5–4 × 2.5–3 µm) [Trechispora farinacea is distinguishable from T. olivacea by its smooth to grandinioid or odontioid hymenophore with whitish to ochraceous hymenial surface and larger basidiospores (4–5 × 3.5–4 µm) [T. hondurensis is separated from T. olivacea by having a hydnoid to partly irpicoid hymenial surface and thin-walled, wider basidiospores (3.6–3.8 × 2.7–2.9 µm) [T. mollis is distinguishable from T. olivacea because it has white-yellow to pale yellow hydnoid hymenial surface, and wider ampullate septa at generative hyphae (reaching 8 µm in width) [The classification of corticioid fungi revealed that two taxa of porales) . In the  surface . Trechis–3.2 µm) ; T. nive–2.9 µm) ; T. molln width) .Trechispora murina is similar to T. farinacea, T. rigida, T. subsphaerospora (Litsch.) Liberta, and T. torrendii Chikowski & K.H. Larss. Based on the character of the grandinioid hymenial surface. However, Trechispora farinacea is separated from T. murina by having a whitish to ochraceous hymenial surface and larger, subglobose to broadly elliposid basidiospores (4–5 × 3.5–4 µm) [Trechispora rigida differs from T. murina due to the presence of its dirty white to buff hymenophore [Trechispora subsphaerospora differs from T. murina by having smooth basidiospores [Trechispora torrendii differs in its pale yellow to yellow hymenophore [Morphologically, enophore  and havienophore . Trechisiospores . Trechisenophore  and has enophore .Trechispora murina is similar to T. canariensis Ryvarden & Liberta, T. fastidiosa (Pers.) Liberta, T. praefocata  Liberta, T. stevensonii (Berk. & Broome) K.H. Larss., and T. yunnanensis C.L. Zhao due to the presence of the ellipsoid, ornamented basidiospores. However, Trechispora canariensis differs from T. murina because it has arachonoid to pelliculose hymenial surface and thin-walled, larger basidiospores (5–7 × 3–3.5 µm) [Trechispora fastidiosa is separated from T. murina by having a membranaceous, whitish to cream hymenial surface and larger basidiospores (6–7 × 4.5–5.5 µm) [Trechispora praefocata differs by having the farinaceous to arachnoid hymenial surface and larger basidiospores (5–6.5 × 4–5.5 µm) [Trechispora stevensonii differs from T. murina by its hydnoid hymenophore and larger basidiospores (4–4.5 × 3–3.5 µm) [Trechispora yunnanensis is separated from T. murina by having the farinaceous hymenial surface and larger basidiospores (7–8.5 × 5–5.5 µm) [–5.5 µm) .Trechispora odontioidea is similar to T. bambusicola C.L. Zhao and T. nivea in having an odontioid hymenial surface. However, Trechispora bambusicola differs from T. odontioidea because it has granulose basidiomata, and the absence of the ampullaceous septa [Trechispora nivea differs from T. odontioidea due to the presence of white to ochraceous basidiomata and broadly ellipsoid to subglobose, thin-walled, larger basidiospores (3.5–4 × 2.5–3 µm) [us septa . TrechisTrechispora odontioidea resembles T. clancularis (Park.-Rhodes) K.H. Larss., T. cyatheae Ordynets, Langer & K.H. Larss., T. hymenocystis (Berk. & Broome) K.H. Larsson, T. invisitata (H.S. Jacks.) Liberta, and T. torrendii Chikowski & K.H. Larss. due to the presence of ornamented or aculeate basidiospores. However, Trechispora clancularis is distinguishable from T. odontioidea due to the presence of its poroid to irpicoid hymenial surface and subglobose to ovoid, larger basidiospores (6–6.5 × 5–6 µm) [Trechispora cyatheae differs from T. odontioidea in having a farinaceous to grandinioid hymenial surface, and broadly elliptical to slightly lacrymiform and adaxial side convex or straight, longer basidiospores (3–3.5 × 2–3 µm) [Trechispora hymenocystis is distinguishable from T. odontioidea by its poroid basidiomata and broadly ellipsoidal to ellipsoidal, larger basidiospores (4.5–5.5 × 3.5–4.5 µm) [Trechispora invisitata differs from T. odontioidea because it has a smooth to porulose, farinaceous to granulose hymenial surface and ellipsoid to ovate, larger basidiospores (4.5–5.5 × 3–4 µm) [Trechispora torrendii differs from T. odontioidea because it has a farinose to grandinioid hymenial surface and larger basidiospores (3.2–3.5 × 2.8–3.2 µm) [ores 6–6. × 5–6 µm 2–3 µm) . Trechis–4.5 µm) . Trechis–3.2 µm) .Trechispora olivacea is similar to T. caucasica (Parmasto) Liberta, T. dimitica Hallenb., T. gelatinosa Meiras-Ottoni & Gibertoni, T. verruculosa (G. Cunn.) K.H. Larss., and T. yunnanensis C.L. Zhao due to the presence of a farinaceous hymenial surface. However, Trechispora caucasica differs from T. olivacea by having a white to greyish hymenial surface and narrowly ellipsoid to reniform with a median constriction, larger basidiospores (5–5.5 × 4–4.5 µm) [Trechispora dimitica differs from T. olivacea in its white to pale greyish hymenial surface, dimitic hyphal system, and shorter basidia (7–10 × 4.5–5.5 µm) [Trechispora gelatinosa is distinguishable from T. olivacea by its coralloid basidiomata and wider basidiospores (3.2–4.5 × 2.5–3.5 µm) [Trechispora verruculosa differs from T. olivacea because it has granulose to hydnoid with small cylindrical aculei, white to yellowish to ochraceous hymenial surface and larger basidiospores (4.5–5.5 × 3.5–4.5 µm) [Trechispora yunnanensis can be delimited from T. olivacea by its larger basidiospores (7–8.5 × 5–5.5 µm) [–3.5 µm) . Trechis–5.5 µm) .Trechispora olivacea resembles T. hypogeton (Maas Geest.) Hjortstam & K.H. Larss., T. nivea, T. rigida, and T. thelephora (Lév.) Ryvarden in having broadly ellipsoid to globose, ornamented basidiospores. However, Trechispora hypogeton is distinguishable from T. olivacea by its stipitate basidiomata and wider basidiospores (3.8–4.3 × 2.7–3.1 µm) [Trechispora nivea differs from T. olivacea by the presence of a odontioid hymenial surface with white to pale ochraceous and wider basidiospores (3.5–4 × 2.5–3 µm) [Trechispora rigida differs from T. olivacea due to the presence of a colliculose hymenial surface and larger basidiospores (4.5–5.5 × 4 µm) [Trechispora thelephora differs from T. olivacea because it has a stipitate basidiomata and larger basidiospores (4.0–5.0 × 3.4–4.5 µm) [–3.1 µm) . Trechis × 4 µm) . Trechis–4.5 µm) .Trechispora are a typical example group of wood-rotting fungi [Trechispora, all taxa in this genus can be separated from the three new species.Wood-rotting fungi are an extensively studied group of Basidiomycota ,64,65,66ng fungi ,34,35,67Trechispora in ChinaKey to 21 accepted species of 1. Basidiospores smooth-------------------------------------------------------------------------------------21′ Basidiospores aculeate, verrucose or ornamented--------------------------------------------------5T. subsphaerospora2. Ampullate hyphae > 5 μm in width, basidiospores angular----------------2′ Ampullate hyphae < 5 μm in width, basidiospores ellipsoid------------------------------------3T. cohaerens3. Basidiospores thick-walled-----------------------------------------------------------------3′ Basidiospores thin-walled--------------------------------------------------------------------------------4T. daweishanensis4. Hymenial surface tuberculate-------------------------------------------------------T. xantha4′ Hymenial surface smooth----------------------------------------------------------------------T. dimitica5. Hyphal system dimitic------------------------------------------------------------------------5′ Hyphal system monomitic-------------------------------------------------------------------------------66. Hyphae without ampullate septa----------------------------------------------------------------------76′ Hyphae with ampullate septa-------------------------------------------------------------------------12T. suberosa7. Basidiospores thin-walled, ovoid to subglobose---------------------------------------7′ Basidiospores thick-walled, ellipsoid-----------------------------------------------------------------8T. yunnanensis8. Basidiospores > 7 μm in length--------------------------------------------------------8′ Basidiospores < 7 μm in length-------------------------------------------------------------------------9T. murina9. Basidiomata margin greyish----------------------------------------------------------------9′ Basidiomata margin white to cream----------------------------------------------------------------10T. bambusicola10. Hymenial surface odontioid---------------------------------------------------------10′ Hymenial surface hydnoid--------------------------------------------------------------------------11T. fimbriata11. Hymenophore with blunt aculei--------------------------------------------------------T. fissurata11′ Hymenophore with sharp aculei--------------------------------------------------------T. hymenocystis12. Sphaerocysts present, hyphae inflated-------------------------------------------12′ Sphaerocysts absent, hyphae uninflated---------------------------------------------------------1313. Ampullate septa > 6 μm in width------------------------------------------------------------------1413′ Ampullate septa < 6 μm in width------------------------------------------------------------------15T. polygonospora14. Basidiospores sparsely verrucose-----------------------------------------------T. mollusca14′ Basidiospores densely aculeate---------------------------------------------------------15. Subhymenium with short-celled hyphae--------------------------------------------------------1615′ Subhymenium with long-celled hyphae---------------------------------------------------------17T. farinacea16. Basidiome thin, ochraceous--------------------------------------------------------------T. rigida16′ Basidiome thick, dirty white to buff-------------------------------------------------------17. Basidiospores thin-walled---------------------------------------------------------------------------1817′ Basidiospores thick-walled--------------------------------------------------------------------------19T. nivea18. Hymenophore with hydnoid-----------------------------------------------------------------T. microspora18′ Hymenophore without hydnoid------------------------------------------------------T. praefocata19. Basidiospores > 5 μm in length---------------------------------------------------------19′ Basidiospores < 5 μm in length---------------------------------------------------------------------20T. olivacea20. Hymenial surface farinaceous with olivaceous--------------------------------------T. odontioidea20′ Hymenial surface odontioid with buff--------------------------------------------


The objective of this study was to determine the relationship between TVOC levels and the risk of BRSs using the Japanese provisional target TVOC level of 400 μg/m3. The relationship between odor intensity and BRSs while the TVOC levels were under 400 μg/m3 was also examined. The study was conducted in a laboratory house (LH) on the campus of Chiba University from 2017–2019. The study included 149 participants who spent 60 minutes in the LH. The participants were asked to evaluate the IAQ of the LH. A significant relationship between the risk of BRSs and the provisional target TVOC level was observed . Furthermore, a significant relationship between odor intensity and risk of BRSs in spaces with TVOC levels less than 400 μg/m3 was detected . In conclusion, the risk of BRSs is significantly lower in spaces with low TVOC levels and low odor intensity. Reducing the concentration of airborne chemicals and odor intensity may improve IAQ and prevent BRSs.The indoor environment, particularly indoor air quality (IAQ), is significantly associated with building-related symptoms (BRSs) in humans. In our previous studies, we demonstrated a significant relationship between BRSs and indoor chemical concentrations. In Japan, the Ministry of Health, Labor, and Welfare (MHLW) guideline recommends an air quality target of 13 volatile organic compounds (VOCs) and a provisional target of 400 μg/m Eighty-nine participants (71.2%) were in their 20s, while 19 participants (15.2%) were in their 30s . Based on the QEESI questionnaire, a total of 44 participants (35.2%)  were sensitive to chemicals. On the day of the test, 114 participants (91.2%)  stated that they were in a “good” state of health. Further, 73 participants (58.4%)  had a history of allergy. Fifty-six participants (44.8%)  had BRSs; Thus, the number of participants with BRSs was greater in Case 2 than in Case 1. Except for age, no participant characteristic was significantly different between Case 1 and Case 2.ΣVOC level, and SOAV between Cases 1 and 2. The IAQ data  are shown in 3 .In this study, 56 participants (44.8%)  had BRSs, and there was a significant difference in the occurrence of BRSs between Case 1 and Case 2  and the occurrence of BRSs in Case 1, SOAV in Case 1 was divided into two groups based on the median SOAV of 6.9 and added as a covariate to the multivariate logistic regression analysis. The results of the analysis are shown in Fourteen participants in Case 1 (29.8%) had BRSs. These participants had BRSs even at ΣVOC level ≤ 400 μg/m3) in reducing the risk of BRSs. We also evaluated the impact of odor intensity on human health at low TVOC levels. The number of participants who reported BRSs during their stay at the LH was 56 (44.8%). The reported prevalence of BRSs (or sick building syndrome) in Asia-Pacific countries is 41.0% in Hong Kong https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool,  13 Dec 2022Reviewer ＃1Thank you for your thorough consideration of our manuscript and for providing constructive feedback. The quality of our manuscript has certainly improved as a result of your comments.We have highlighted all of our changes in the revised manuscript in red. A point-by-point response to the reviewers’ comments is given below.------------------------------------------------------------------Comment: The authors greatly appreciate your consideration of our manuscript and helpful comments. We divided your advice into a few points and have addressed each of these suggestions in the responses provided below.------------------------------------------------------------------Comment 1: Title should be change, odor in title replace with indoor environment.Our reply:Thank you for your advice. We changed the title to “Is indoor environment a risk factor for building-related symptoms?”.------------------------------------------------------------------Comment 2: COVID-19 portion remove from manuscript as this study conducted 2017-2019. Focus only VOCs and biological agents which you have studied and data.Our reply:Thank you for the comment. We removed the section about COVID-19 from the Introduction and focused only on VOCs and other factors.------------------------------------------------------------------Comment 3: Please explain why authors use only 2 case study, as in both cases sample size also different (in case 2- sample size is double), for comparative conclusion, must have study with 3 or 5 cases.Our reply:Thank you for the comment. In this study, we tried to examine the provisional target value of 400 µg/m3 set by the Japanese Ministry of Health, Labor, and Welfare. Thus, we divided the scenes into two: the scene with TVOC > 400 µg/ m3 is referred to as Case 1, and the second scene with TVOC < 400 µg/ m3 is referred to as Case 2. The number of participants was not the same as they were divided by TVOC concentration values. We revised the aim of this study in the Introduction.------------------------------------------------------------------Comment 4: Line 83-85: give the detail information of study site area, have any natural air purifier (indoor plants) artificial air purifier inside the rooms and other building construction material details (if available), It also effect the indoor environment quality.Our reply:Thank you for the comment. As you said, some devices and things affect indoor air quality. We added details of the study site in the text as follows:“The structure of the LH is a typical Japanese wooden house constructed from timber. The LH was constructed mostly with F☆☆☆☆ (F-four stars) labeling. The F☆☆☆☆ rating is a classification of building materials in Japan based on the formaldehyde emission rate, which is defined by Japanese Industrial Standards (JIS), Japanese Agricultural Standards (JAS), and the Ministry of Land, Infrastructure, Transport, and Tourism. Four-star building materials, including boards, adhesives, insulation, and paints, can be used without limitations on the area of use.The LH was equipped with a mechanical ventilation system designed to ventilate 0.5 times per hour. The LH was also equipped with air conditioners that control the temperature and humidity, but no air purifiers were used. The rooms of the LH were not decorated with any indoor plants.”------------------------------------------------------------------Comment 5: Line 89-93: specify age group, gender in text alsoOur reply:Thank you for the comment. We have specified age groups and gender in the text.------------------------------------------------------------------Comment 6:　Line 132-135: this data only questionnaires base please justify with diagnostic based results.Our reply:Thank you for your comment. Building-related symptoms (BRSs) and Sick building syndrome (SBS) are usually defined as the occurrence of nonspecific symptoms among populations in specific buildings. In epidemiological studies worldwide, BRSs and SBS are often diagnosed using questionnaires, such as the MM040 . In this study, we diagnosed BRSs and SBSs using a questionnaire developed based on the “Consultation Manual for Trace Chemicals in the Indoor Environments” issued by the Japanese MHLW. We described the questionnaires in the “Questionnaire” section.------------------------------------------------------------------Comment 7: Line 199-201: In which parameters used for concluding results as health is good, explain clearly.Our reply:Thank you for the comment. Regarding the health of the day, we asked participants to judge their physical condition subjectively. We revised the “Questionnaire” section as follows:“The participants were asked to subjectively score their health status on the day of the evaluation using a scale of 1–4: 1, very good; 2, good; 3, not good; or 4, bad. We defined 1 and 2 as “good” and 3 and 4 as “bad.””------------------------------------------------------------------Comment 8: Line 201: history of allergy- which types of reports you have for individuals motioned.In table shown the data for personal factors, one of them physical condition most of them health and not any major health issues reported, until 50 % of them are have medical history of allergy. In pervious mentioned all individuals participate in this study are healthy explain it.Our reply:Thank you for the comment. In this study, the most common “medical history of allergy” was hay fever. Most symptoms of hay fever appear in early spring (February to May) in Japan. As this study was conducted from May to October, most participants with a history of hay fever had no symptoms at the time of the test. Thus, they may have evaluated themselves as healthy on those days. However, we changed “healthy volunteers” to “participants.”------------------------------------------------------------------Comment 9: Discussion section updated with recent and more related paper; this portion need improvement.Our reply:Thank you for the comment. We updated the Discussion with recent and related papers.------------------------------------------------------------------Comment 10: Rewrite abstract and conclusion section.Our reply:Thank you for the comment. We rewrote the abstract and conclusion.Reviewer ＃２------------------------------------------------------------------Comment: The work described in the manuscript is based on questionnaire, air sampling and odor activity testing. Data are methodically and accurately analyzed. The conclusions are made basically reflecting to the results formulated.Our reply:We sincerely appreciate your review and comments.------------------------------------------------------------------We would like to take this opportunity to express our sincere thanks to the reviewers who identified areas of the manuscript that needed corrections or modifications. We would also like to thank you for allowing us to resubmit a revised copy of the manuscript. We hope that the revised manuscript is acceptable for publication in PLOS ONE.Sincerely,Kayo Tsumura Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoi-tyou, Inage-ku, Chiba 263-8522, Japan Tel.: +81-43-290-3878 tsumu-kayo@chiba-u.jpEmail Address: AttachmentResponse to Reviewers.docxSubmitted filename: Click here for additional data file. 14 Dec 2022Is indoor environment a risk factor for building-related symptoms?PONE-D-22-23122R1Dear Dr. Tsumura,We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at onepress@plos.org.If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact Kind regards,Rajeev SinghAcademic EditorPLOS ONEAdditional Editor Comments :Reviewers' comments: 17 Jan 2023PONE-D-22-23122R1 Is indoor environment a risk factor of building-related symptoms? Dear Dr. Mori:I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. onepress@plos.org.If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact plosone@plos.org. If we can help with anything else, please email us at Thank you for submitting your work to PLOS ONE and supporting open access. 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INTRODUCTION-OBJECTIVES. Similar to philosophy (regina-scientiarum) is psychiatry fundamental-discipline for all-medical&social sciences. Immanuel KANT: Primus inter pares of ARISTOTELES&PLATON considered over 200years ago physiological and pragmatic anthropology-[1]. Social physiology is given-[3-4]. Consideration of social-psychopathology in German-justice-[2].REFERENCES. [1]-Kant,I: BdXI,371-393, BdXII,399,625-638:Suhrkamp-TB-Wiss. [2]-Neu,E/Michailov, M.Ch/Welscher,U/et-al.: 2a.-FISP-2018-Beijing/Philos ; 2013-Athens Abstr.Book(AB):464-5/503-4/766; 2008-Seoul-ProcVol.4: 101-108/195-214/229-237; 2003-Istanbul:273-281; IVR-2019-Luzern (Law), Progr-Book p.116. 2b.-EPA-2020-Madrid, Eur.Psychiatry 63S, EPP0834/5+EPV0581/1470; EPA-2019-Warsaw, 56S,S689; EPA-2018-Nice, 48/S1, S623&567&662. 2c.-WPA-2021-Bangkok (in-press). 2019-Lisbon, E-Poster WCP19-2137/-1822/-1839. 2018-Mexico-City, Abs.-Book WCP18-0584/-0625/-0643/-0654. 2011-Buenos-Aires, AB:PO1.200. [3]-Glasachev,O: Sechenov Physiol.J 80/no5, 1994,p.139-143 (Russian), ref. in English. [4]-Seeley,T.D: Social-Physiology Honey-Bee, Book-1996.[5]-Daily-journal-“tz”-München, esp. every Tuesday 2016-2019: reports on Res.-Houses,e.g. 14.02.2019, 15.02.17, 06.12.16/p.10, 18.10.16/p.10, 17.11.2020/p.6. Süddt.Zeitung-München no172/p.30,2017. Mü.-Merkur:16.11.2020/p.32; 19.11.2020/p.29. FAZ:20.10.2019/p.53; 16.11.2020/p.21. BUROW,P: Justiz am Abgrund&Ein Richter klagt an. GNISA,J, Präs.-Dt.Richterverein: „Ende der Gerechtigkeit“, Herder-2017. SCHLEIF,T/Amtsrichter: Buch „Urteil: ungerecht“, zeit-online 24.10.2019. Hans-Jochen&Liselotte VOGEL:„Mehr Gerechtigkeit“, 2019 „Wohn-Irrsinn“(Enteignungen). ZANTKE,S (Richter-Amtsgericht-Zwickau): TV-Programm„Auf einen Blick“ Nr.47,2018,S.24. [6]-Luetge,Ch et-al.(ed): Experimental-Ethics, Palgrave-Macmillan 2014. [7]-Pegoraro,R/Vatican: «Arzt&Christ» 38:3-55,1992.RESULTS Prominent German experts for justice: Patrick BUROW, Jens GNISA/President Law-Association/Germany, Torsten SCHLEIF/Amtsrichter, Hans-Jochen VOGEL/Ex-Minister, Stephan ZANTKE/Richter reflect in their books fundamental-criticism of German justice [5]. Inst.-Ecol.-Med./IUM investigated psychopathology of juridical-offices&law-court in Munich (Amtsgericht). Analysis suggests presence of symptoms for pseudologia-phantastica, psychopathy, cyclophrenia (esp.mania),etc. conc. observations on many persons (n>30).CONCLUSION. Juridical situation in Germany demonstrates contradiction to human-rights , ignoring moral-philosophy, related to human obligations/I.Kant-[1], experimental ethics/Ch.Luetge et-al.-[6], medical personnel/R.Pegoraro-[7]. Only paradigm change in law-policy incl. enlarged implication of moral philosophy-theology, psychiatry-psychology, social philosophy in juridical eduction & practices could counteract disastrous juridical situation in Germany and on global level, supporting UNO-AGENDA21 for better education-health-ecology-economy (see 2.).No significant relationships.