The AgingME Geriatrics Workforce Enhancement Program (AgingME GWEP), a statewide collaboration led by the University of New England and the University of Maine, is guided by an annual statewide survey of community and professional stakeholders. The aim of this research is to identify training and resource gaps related to age-friendly healthcare and topics of interest. Of the 245 survey respondents, 15% indicated existing knowledge of the 4Ms framework. The top sources of 4M’s framework exposure included trainings or webinars (30%) and web-based resources (19%). Of those with knowledge of the 4M’s, 33% of providers and 29% of older adults/community members reported employing the 4Ms in their professional practices and personal lives, respectively. Respondents also noted the need for more training on how to use technology to locate healthcare information (33%), using technology to reduce isolation and loneliness among older adults (29%), and keeping providers connected with older patients (26%). Additional write-in responses (11%) suggest a need for general technology training and improving access to technology overall. Respondents' (N = 157) top five categories for needed aging-related training topics were community resources for older adults (15%), aging-in-place (14%), exercise and nutrition (11%), improving provider/patient communication (9%), and 4M’s of age-friendly healthcare overview (8%). Responses also identified themes related to improving patient/provider communications, availability of resources, and ageism that could be addressed through upcoming GWEP activities. Results indicate a need to facilitate the translation of 4Ms knowledge into practice and increasing technology training and access.


Pandemic is accompanied by “infodemic” that is related to higher anxiety . We suggest that indefinite and stressful situation of pandemic provoke magical thinking leading to lower adherence with recommendations for self-isolation.The aim was to reveal the structure of beliefs about reasons, manifestation and consequences of coronavirus and their relationship with magical thinking, anxiety and COVID-19-related behaviour.In April 2020 (2-3 weeks of self-isolation regimen) 402 adults aged 18-64 years old filled checklist including beliefs about pandemic , Magical Ideation Scale Eckblad, Chapman, 1983) as well as scales measuring anxiety and protective behaviour in pandemic and monitoring of information about coronavirus .Factor analysis revealed three groups of radical beliefs about coronavirus . Belief about the particular meaning of coronavirus was associated with the magical thinking (r=.21), less anxiety about infection (r=-.19) and poorer adherence to self-isolation (r=-.26). Belief in the negligence as a cause of coronavirus was more typical for those with better adherence (r=.18) while catastrophic beliefs about the consequences of pandemic were related to frequent monitoring of the information about the pandemic (r=.24), and anxiety regarding future negative consequences of the pandemic (r=.46).Dysfunctional beliefs about coronavirus could be a factor of poorer adherence related to magical thinking and could be addressed in psychological interventions. Research is supported by the Russian Foundation for Basic Research, project No. 20-04-60072.


We tested the following genotype-related mechanisms generating race-dependent disparity in Alzheimer’s Disease (AD) risk: i) the frequencies of SNPs with genotypes associated with AD are higher in the Black subpopulation; ii) the effects on AD risk of genotypes associated with increased AD risk is higher in the Black subpopulation; iii) there is a small group of SNPs with a large difference in the effects on AD race-dependent risk generating disparities; alternatively, the disparities are generated by a collective effect of multiple SNPs with minor or moderate effects. We modified the GWAS algorithm to use it with the Cox regression multivariable model and the outcome accounting for race-related differences in AD risk. Using the modified GWAS we have identified loci in charge for the disparity between Whites and Blacks and used the results along with SNPs of a special interest which were identified from the literature in the Cox multivariable regression model and generalized Oaxaca-Blinder approach. The following genes had the strongest effects on racial disparities: i) NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor; ii) RPA3-UMAD1 loci RPA3 replicates protein A, interacting with gastric tumor and hepatocellular carcinoma; iii) TOMM40 associated with an increased risk of developing late-onset AD; iv) ACE - responsible for making the enzyme which converts angiotensin which regulates blood pressure; v) PSME3IP1 - proteasome activator subunit 3 interacting protein 1; vi) MARCHF1 regulator of glucose-tolerance and lipid storage and vii) LINC01146 which belongs to coagulation cascade pathway and linked to hepatocellular carcinoma.


Cognitive Stimulation Therapy (CST) is an evidence-based treatment for people living with dementia that is not in widespread use in the United States. To better understand barriers and facilitators to implementation of CST, we conducted virtual focus groups of newly trained facilitators of Cognitive Stimulation Therapy (CST). Of 12 facilitators trained, representing two settings of care (The Program for All-inclusive Care of the Elderly and a Continuing Care Retirement Community), 4 facilitators, representing Social Work n = 2, Speech Therapy n = 1, and Recreation Therapy n = 1, participated. We analyzed interview transcriptions using framework analysis guided by constructs from the Consolidated Framework for Implementation Research (CFIR). Themes that emerged across constructs were 1) balancing competing personal, stakeholder, and organizational needs; 2) lack of mastery experiences and the need for opportunities for more practice, reflection, and feedback from trainers; 3) building a community of facilitators to provide peer support; 4) logistical concerns; and 5) identifying appropriate participants who would most benefit from CST. The barriers to implementation imposed by the ongoing COVID-19 pandemic were also a cross-cutting theme. Many of these barriers are readily managed, and professionals who implement CST in their sites should be aware of and take into consideration these barriers and facilitators.


Pharmacists play an important role in infection control and antimicrobial stewardship teams in hospitals and the community. The need for education on antimicrobial resistance (AMR) and clinical infectious diseases (CID) is increasing. However, the status of Japanese pharmaceutical education on CID and AMR is unclear.We conducted a nationwide cross-sectional survey of pharmaceutical department in Japanese universities between February and March 2022. Data on the following were collected using questionnaires: 1) basic information; 2) number of faculty members with experience in CID; 3) lecture times for CID and AMR; 4) self-evaluation of CID and AMR education; and 5) the most important issues in CID and AMR education. Descriptive analyses were conducted.Among the 74 participating universities, 44 (59.5%) universities responded. The median number [IQR] of faculties of infectious disease education was 7 [4–12], and clinical faculties was 3 [1–6]. Twenty-seven (62.8%) of the universities had faculties with clinical experience in infectious diseases. Lectures time for CID and AMR varied among the universities.Respondents indicated that CID and AMR lectures were insufficient, compared to microbiology basic lectures. Additionally, insufficient lecture time and specialists were the most common responses as the most important issues in CID and AMR education.University background and questions regarding CID and AMR lectures (N=44)Boxplot of lectures time for clinical infectious disease and antimicrobial resistance educationSelf-evaluation of clinical infectious disease and antimicrobial resistance educationThis study revealed that educational status and resources for CID and AMR education varied widely, and that practical lectures on CID and AMR may be insufficient. We suggest that the entire core curriculum and resources, including the number of faculties, needs to be examined and improved.The most important issues in clinical infectious disease and antimicrobial resistance education.All Authors: No reported disclosures.


Our previous systematic review on the health benefits of different sport disciplines included 69 studies published before 2013. We found moderately strong evidence of health benefits for running and football while the evidence for other sport disciplines was either inconclusive or tenuous. The purpose of this report is to update the evidence base on published studies through 2013-2019.A systematic literature search of observational and experimental studies on the association between the participation in sport and health outcomes was conducted through electronic databases: MEDLINE via PubMed, Scopus, and Web of Science. The inclusion criteria were: participants heathy adults; type of studies cross-sectional, cohort or intervention designs; study group participation in specific sport disciplines; non-participation comparison group; health-related outcome variables in terms of mortality, morbidity, disease risk factors and function. Studies on sport injuries were excluded.A total of 3909 titles and abstracts of studies published between 2013-2019 were identified for potential inclusion. The study selection process yielded 30 studies for further assessment. These studies included 26 different sport disciplines with 54 sport vs. no sport comparisons. The most prevalent sports were cycling (10 studies) and running (8 studies). Together with the previous systematic review the combined data includes 99 studies, 40 sport disciplines and 159 sport vs. no sport comparisons. Significant health benefits were found for a range of sport disciplinesThe updated systematic review provides new relevant data for an extended analysis of the health benefits of different sport disciplines and strengthens the existing evidence base for the promotion of health through participation in sports.


Nature Communications 10.1038/s41467-022-34321-6, published online 04 November 2022Correction to: The original version of this Article contained an error in the caption of Figure 3a, which incorrectly read ‘showing ratios of rapid intensification (RI) cases satisfying the critical environmental thresholds divided by entire samples satisfying thresholds (blue histograms) and the analogous ratios for cases where the critical thresholds are not met (red histograms)’. The correct version replaces sentence with ‘showing the probability of rapid intensification (RI) for cases satisfying the critical environmental thresholds (blue histograms) and the probability of RI for cases where the critical thresholds are not met (red histograms)’. This has been corrected in both the PDF and HTML versions of the Article.


ALS Forum  is an online support group for those who have motor neuron disease or amyotrophic lateral sclerosis (ALS). It provides information, advice, connection, care, and assistance to persons living with ALS and their family caregivers. This study aimed to analyze the online discussion posts by caregivers of persons with ALS and assess their perceptions, experiences, and challenges of using assistive technologies (AT). Posts were extracted from the ALS caregiver discussion forum via web scraping using Python in March 2022. The extracted posts are dated between June 2005 and January 2022. The total number of posts and replies generated during this period was 52,292 by 2,397 unique users. Additional searches were conducted using assistive technology-related keywords to create the text dataset. A total of 263 posts by 137 unique users were identified. After the initial review, 186 posts were included in the final analysis. Thematic analysis revealed six major themes: (1) Uses of AT ; 2) Barriers and Facilitators ; 3) Usability (hardware and software-related); 4) Sharing Experience on AT; 5) Giving Advice; 6) Seeking Information on AT. The findings are consistent with previous literature that online health discussion forums provide access to rich data that contains lived experiences of patients and caregivers. The findings may inform the design of future assistive technology that incorporates the patients’ and caregivers’ perspectives to increase the adoption and long-term sustainability of the technology for people living with ALS and their caregivers.


A 54-year-old man presented with cough and 3-month history of pain in bilateral knees and fingers. Physical examination revealed digital clubbing  and b an(1). 95%-97% of the cases are caused by underlying conditions; the most common being non-small cell lung carcinoma (2). Screening for underlying conditions, particularly lung cancer, should be performed after hypertrophic osteoarthropathy diagnosis.Hypertrophic osteoarthropathy is characterized by digital clubbing accompanied by arthralgia and periostosis and typically involving the tibia and fibula NoneHK wrote the manuscript, and AO and KS critically revised the manuscript for the intellectual content. All authors have read and approved the final manuscript.Written informed consent was obtained from the patient.Ethical approval was waived by the Ethics Committee of Tokyo Metropolitan Bokutoh Hospital.


Previous research has established the role of lifelong learning in promoting psychological wellbeing and active aging. Population aging necessitates an understanding of the unique opportunities and challenges around formal and informal learning in later life. This paper will share findings from a mixed methods study with the MIT AgeLab 85+ Lifestyle Leaders, a panel comprised of octogenarians and nonagenarians from across the United States. Drawing on an online survey and virtual focus groups with 29 Lifestyle Leaders from January 2021, findings suggest the Lifestyle Leaders most often learned new things from talking with others (46%) and reading print (54%) or online (54%) sources. The majority were familiar with attending in-person lectures or classes (89.7%) and were now using videoconferencing to do these (78.6%). A majority (56.7%) had or are currently participating in a lifelong learning program. Most consider themselves lifelong learners and described this around remaining curious and engaged with life, choices around what one learns, and greater enjoyment of learning. In the survey, a plurality of Lifestyle Leaders indicated the top two challenges affecting their ability to learn were sensory burdens  (35%) and their energy level (32.4%); focus group data revealed that recall also is a barrier. Focus group data further highlighted generational experiences around early life learning and career paths, specifically how gender roles, diagnoses of learning disabilities, and evolving digital technology have affected these and changed over the course of their lifetimes.


People with schizophrenia have a life expectancy that is 10–20 years shorter than the general population. The high incidence of metabolic syndrome, cardiovascular disease and diabetes mellitus in this patient group are thought to be major – and potentially modifiable – factors contributing to this premature mortality. Therefore, annual monitoring of physical health parameters is recommended by organisations including the Scottish Intercollegiate Guidelines Network (SIGN). The SIGN guideline on schizophrenia advises that the following parameters are checked annually for patients with schizophrenia who are on anti-psychotics: ECG, blood glucose, lipid profile, prolactin, BMI/weight, smoking status and blood pressure. Traditionally, this monitoring is overseen in the community by general practitioners. This audit aimed to capture how the COVID-19 pandemic impacted on the annual physical health monitoring of patients under the care of NHS Borders Community Rehabilitation Team.A retrospective audit was performed by reviewing notes of the 100 patients on the NHS Borders Community Rehabilitation team caseload. Notes from the years of 2019, 2020 and 2021 of all 100 patients on the caseload were reviewed, for documentation of the following seven parameters as recommended by SIGN: ECG, blood glucose, lipid profile, prolactin, BMI/weight, smoking status and blood pressure. Results were then entered manually into a secure spreadsheet. Permission for this audit was granted by NHS Borders.Initial results for the parameters of: ECG, blood glucose, lipid profile and prolactin levels demonstrate that routine monitoring of all four domains has decreased since the start of the COVID-19 pandemic. In 2019 the following numbers of patients had monitoring in these domains: ECG 56 (56%); blood glucose 84 (84%); lipid profile 74 (74%) and prolactin levels 62 (62%).During 2020, the number of patients having monitoring in all four domains fell: ECG 31 (31%); blood glucose (72%); lipid profile 64 (64%) and prolactin levels 48 (48%). During 2021, monitoring levels remained low: ECG 30 (30%); blood glucose 71 (71%); lipid profile 62 (62%) and prolactin levels 43 (43%).Data collection for the parameters of blood pressure, BMI/weight and smoking status is ongoing.Initial results indicate that the COVID-19 pandemic has negatively impacted on the routine physical health monitoring of patients under the care of the community rehabilitation team in NHS Borders. These results imply opportunities to treat and prevent conditions such as diabetes mellitus and hypercholesterolemia are being missed, further perpetuating an existing health inequality for patients with severe and enduring mental illness.


Inflammatory bowel disease (IBD) advanced training programs in Canada are heterogenous in their education, structure, and case exposure, resulting in differences in trainee experience. While competency based medical education (CBME) is becoming the primary educational framework in residency training, there is no CBME-based curriculum for IBD advanced training programs. Adopting a CBME framework for IBD fellowships may help standardize training to increase competence.The purpose of this study was to develop a CBME-based curriculum for IBD advanced training programs in Canada.Strategic groups consisting of 25 IBD experts were assigned to develop 15 entrustable professional activities (EPAs), which were then refined by experts in medical education and curriculum development. Acceptable EPAs were assessed using an electronically administered round-less Delphi panel. Panel members evaluated each EPA using a Likert scale, which asked participants to consider appropriateness of each EPA for an advanced IBD curriculum. A consensus strength greater than 70% was the acceptable threshold for inclusion into the final curriculum. Milestones were modelled after CanMED roles for each EPA.Of the 15 initial EPAs, nine were recommended for the roundless Delphi panel by the selection committee: (1) identification, diagnosis, and treatment of new onset IBD; (2) assessment and treatment of outpatients with IBD; (3) the endoscopic evaluation of disease activity and the effective communication of endoscopic findings for patients with IBD; (4) provide effective inpatient management and coordinate transition to outpatient care for patients with IBD; (5) recognize and institute preventive health maintenance strategies in patients with IBD; (6) management and treatment of special populations with IBD; (7) identification, diagnosis, and treatment of the various extraintestinal manifestations of IBD; (8) Engage health care systems to improve the quality of care for patients with IBD; (9) engage in scholarly activities related to IBD. Eight of the nine EPAs achieved a consensus score greater than 70%, with the EPA, ‘engage in scholarly activities related to IBD’ failing to meet this cut-off. Associated milestones were developed for the eight final EPAs.This study was the first attempt to develop a CBME-based IBD curriculum in Canada. With proper funding and guidance, we hope our model can be implemented across Canada in IBD advanced training programs. These methods may also help facilitate the development of CBME curricula for other advanced training programs.NoneNone Declared


Mediterranean ports are sources of significant economic activity and at the same time they act as recipients of considerable anthropogenic disturbance and pollution. Polluted and low-in-oxygen sediments can negatively impact benthic biodiversity and favour recruitment of opportunistic or invasive species. Macrobenthic communities are an important component of the port biota and can be used as environmental quality indicators. However, a baseline database for benthic biodiversity in Mediterranean ports has not yet been widely established.Mollusca were the most abundant group (34%) in all ports. The highest percentage of opportunistic taxa per station was found before the touristic period in the shipyard of Heraklion port (89.3%).Macrobenthic assemblages were recorded in three Mediterranean touristic ports under the framework of the ENPI CBC MED project MAPMED (MAnagement of Port Areas in the MEDiterranean Sea Basin). Samples were collected from Cagliari , Heraklion  and El Kantaoui (Tunisia) ports during February, May and September 2012. The sampling stations were selected according to the different sectors within each port . A total of 277 taxa belonging to 12 phyla were found, of which the 96 taxa were present in all three ports. El Kantaoui port hosted the highest number of macrobenthic taxa.  Mediterranean ports are sources of significant economic activity and they strongly support local, regional and national economic development. The Mediterranean Sea hosts about 480 ports and terminals and is one of the busiest maritime areas of the world . ShippinThis dataset includes macrobenthic taxa identified in three touristic ports in the Mediterranean, located at Cagliari , Heraklion  and El Kantaoui (Tunisia) . SamplinMAPMED: MAnagement of Port areas in the MEDiterranean sea basinDr Eva Chatzinikolaou , Dr Panagiotis Damianidis (taxonomic identification), Dr Christina Pavloudi (taxonomic identification), Dr Katerina Vasileiadou (taxonomic identification), Dr Sarah Faulwetter (taxonomic identification), Kleoniki Keklikoglou (taxonomic identification), Wanda Plaiti (taxonomic identification), Dimitra Mavraki (data management), Stamatina Nikolopoulou (data management) and Dr Christos Arvanitidis .Mediterranean touristic ports: Cagliari , Heraklion  and El Kantaoui (Tunisia).During this study, differences in macrobenthic assemblages were examined across three levels: a) geographical differences (three countries), b) use-sectoral differences (3-5 stations within ports) and c) temporal differences (three seasons in relation to the touristic period).This project has been financed by the European Union under the ENPI CBC Mediterranean Sea Basin Programme in the framework of the project “MAnagement of Port areas in the MEDiterranean Sea Basin” (MAPMED) (Grand Contract 6/2019-25/ 7/2011). This publication has been supported by the LifeWatchGreece infrastructure (MIS 384676), funded by the Greek Government under the General Secretariat of Research and Technology (GSRT), ESFRI Projects, National Strategic Reference Framework (NSRF) and from LifeWatch ERIC.Five replicates of sediment samples were collected from each station using a box corer (13.5 cm × 13.5 cm × 16 cm) manually operated from a small boat. A Garmin 60 CS portable GPS and a depth meter were available on board to record the exact position and depth of each station respectively. The sediment samples were sieved through a 0.5 mm sieve and then fixed and preserved in 5% formaldehyde buffered with seawater and stained with Rose Bengal. The benthic organisms were sorted out of the sediment under a stereoscope, counted and identified down to the lowest possible taxonomic level.http://www.marinespecies.org/aphia.php?p=match) on 10-03-2021.All scientific names were standardised against the World Register of Marine Species using the Taxon Match tool (2) located on the southern coast of Sardinia . The port of Heraklion  and it is located on the northern coast of Crete (Greece). The port of El Kantaoui  on the eastern Tunisian coast. Both the ports of Heraklion and Cagliari host a leisure marina, large passenger, cruise and cargo vessels, while El Kantaoui port offers moorings only for smaller fishing boats, luxury yachts and boats for sporting activities. Heraklion port has also a shipyard section.Three Mediterranean touristic ports were selected as study sites and they are presented in Fig. ion Fig. C is medioui Fig. D is a smSampling stations were selected in order to achieve good spatial coverage in each port and also to represent sectors with different uses according to the Water Management Units in MAPMED Action Plans MAPMED 2015). Four stations were selected in the port of Heraklion, five stations in the port of Cagliari and three stations in the port of El Kantaoui , Annelida (28.2%) and Arthropoda (24.2%) were also highly represented, while each of the remaining groups contributed less than 5% in the benthic assemblages studied  was calculated for each station as the percentage of abundances for eta taxa  in the teta taxa . The higAdditional statistical analysis has been applied to the species composition matrices of the specific dataset by Data range: 2012-2-13 – 2012-9-25.Three seasonal sampling campaigns were carried out during 2012: one in winter (February), one in spring before the beginning of the touristic season (May) and one in late summer after the touristic season (September).Benthic communities and environmental parameters in three Mediterranean ports .5% formaldehyde buffered with seawater.Hellenic Centre for Marine Research (HCMR), Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Heraklion, Crete, Greece.Open Data Commons Attribution LicenseCreative Commons Attribution (CC-BY) 4.0 License. All data in the database can be freely used provided it is fully cited even if only partially used.This work is licensed under a Benthic communities and environmental parameters in three Mediterranean ports .https://www.gbif.org/dataset/9b11f305-fb7a-4a65-826e-7fb97af06e5fhttp://ipt.medobis.eu/resource?r=mapmed_ports1Benthic communities and environmental parameters in three Mediterranean ports .Darwin Core Archive.UTF-8http://ipt.medobis.eu/resource?r=mapmed_portsMedOBIS (Mediterranean node of Ocean Biodiversity Information System),Integrated Publishing Toolkit (IPT) which has been established through the LifeWatchGreece Research Infrastructure and is hosted in the Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC) of the Hellenic Centre for Marine Research (HCMR). The data are also harvested by and made available through the Ocean Biodiversity Information System (OBIS).The dataset is available as a DarwinCoreArchive and all fields are mapped to DarwinCore terms.The dataset is available via the This publication refers to the most recent version of the dataset available through the IPT server or MedOBIS. Future changes to the dataset due to quality control activities might change its content or structure.The current publication refers to the "occurrence" source file (txt file) that is associated with the particular dataset. Additional details about the sampling events can be found in the "event" source file (txt file) associated with the same dataset.


The current coronavirus pandemic (Covid-19) is posing new critical challenges on mental health due to widespread social alarm as well as long lasting “physical distancing” as a result of public health protection measures or voluntary conduct. In a period of uncertainty, certain rewarding behaviors, such as the use of the Internet, exercise among other coping strategies might have increased considerably. We will share the results of an international cross-sectional investigation on the impact of physical-distancing on such potentially addictive behaviours to mitigate the pandemic effects, while identifying the most risky patterns and vulnerable populations. The studied sample consists of 3161 participants from Italy (41%), Spain (16%), the UK (12%), Lithuania (12%), Portugal (11%), Japan (6%), and Hungary (4%). Results are currently being analysied.No significant relationships.


Depressive symptoms affect the physical and cognitive health of approximately 20% of older adults. These symptoms have strong, bidirectional ties with physical activity levels and mobility disability. Physical activity has a positive impact on mood and depression and is highly recommended for symptom management across all ages. However, it’s unclear whether elevated depressive symptoms interfere with potential benefits that physical activity has on other health outcomes like mobility loss. The Lifestyle Interventions and Independence for Elders (LIFE) Study randomized over 1,500 older adults (aged 70+) to either a physical activity (intervention) or successful aging (control) program with an average of 2.2 years of follow-up. Our analysis used Cox proportional hazards models to evaluate whether elevated depressive symptoms -11 scale with a cutoff score of 16/22 points) moderated the relationship between intervention status and the primary outcome . In a secondary analysis of 1,534 older adults , we confirmed significant main effects of both the physical activity intervention and elevated depressive symptoms on incident major mobility disability but found no evidence of moderation . Results indicate that the benefits of the intervention were comparable between those with and without significant depressive symptoms at baseline, supporting the inclusion of individuals with depression in clinical trials. In addition to potential symptom relief, promoting physical activity in older adults with depression is important for protecting against mobility loss.


Persons Living with HIV (PLWH) with chronic kidney disease progress to end-stage renal disease (ESRD) at a faster rate than HIV-negative individuals. Unfortunately, there is increasing data to suggest that PLWH are less likely to be waitlisted. We reviewed the transplant care continuum among PLWH at the Medical University of South Carolina (MUSC).st, 2012 and December 31st, 2021. Cases were included if a PLWH and ESRD had not died before being referred for kidney transplant, had evidence of pursuit of kidney transplant, and sufficient data of their transplant process were available in the medical record system. Descriptive statistics were used to analyze demographic and clinical characteristics as well as the transplant care continuum of PLWH and ESRD at MUSC.This was a retrospective review of PLWH and ESRD who either received care at MUSC Health Care System or were referred for Kidney transplant at MUSC between May 157 PLWH and ESRD were included in the analysis. Of these, 45 (79%) were referred for kidney transplant (Table 1). The median age at the time of referral was 52 (range 26 - 78), 33 (73%) were males and 42 (93%) were of the Black race. The most common causes of ESRD were Multifactorial (36%), HIV-Associated Nephropathy (24%) and unknown (16%). Almost all patients had hypertension (96%) and 29% of patients had diabetes. Additionally, prevalent comorbidities include psychiatric conditions (53%), history of substance use (43%) and history of tobacco use (36%). Of those referred for kidney transplantation, 32 (71%) started a transplant evaluation, 24 (53%) completed the transplant evaluation, 22 (49%) were waitlisted, and 13 (29%) were transplanted. Common reasons why patients did not complete transplant evaluation included not meeting HIV criteria for transplant (9%), having too many comorbidities (9%), and not completing testing (9%).Clinical Characteristics of the 45 HIV Patients with ESRD Who Were Referred to Kidney Transplant at MUSCClinical Data on Transplant Care Continuum, n = 45The majority of PLWH with ESRD seen at MUSC were referred for kidney transplant and started the evaluation process. More is needed, though, to assist patients in completing the transplant evaluation process and making it to the transplant waitlist, with the ultimate goal of transplantation.All Authors: No reported disclosures.


Psoriazis and major depressive disorder (MDD) have a high degree of overlap, and inflammatory citokines like tumor necrosis factor alpha, interleukins 1, 2, 6 and 10, and C-reactive protein have been involved in their common pathogenesis. The prevalence of MDD in patients with psoriazis has been reported to range between 28% to 67%.To monitor the core symptoms evolution in patients diagnosed with psoriazis and MDD during antidepressant treatment.Four patients diagnosed with psoriazis and MDD (according to the DSM-5 criteria) were monitored during 6 months using Physician Static Global Assessment (PSGA), Hamilton Depression Rating Scale (HDRS)-17 items, and Global Assessment of Functioning (GAF). All patients underwent specific psoriazis and antidepressant treatment .All patients significantly improved their depressive symptoms during sertraline or escitalopram treatment , while their global functioning increased . The PSGA score decreased and reached a level of signifiance at week 24 . The duration of active periods of psoriazis was less longer during the 6 months of monitoring than in the 6 months previous to the antidepressant initiation . No treatment discontinuation due to low tolerability was reported.Antidepressant treatment with selective serotonin reuptake inhibitors is efficient and well tolerated in patients with MDD and psoriazis. The duration of active symptoms of psoriazis tends to be less longer than previous to the antidepressant initiation.


Byssinosis is a disabling occupational lung disease caused by cotton dust. It is a well-known occupational respiratory disease in cotton industry workers caused by cotton dust pollution. Many studies have been documented the effects of cotton dust onpulmonary function among workers employed in cotton-spinning mills. However, little data exist on the prevalence of this disorder in female workers particularly in western part of India. The present study was conducted to analyze the effects of exposureto cotton dust on pulmonary functions among female workers. The study was designed to assess the effects of exposure to cotton dust on lung functions among female cotton industry workers. Study group comprises 50 Female workers of cotton industry andcontrol group comprises 50 age matched females who were neither worked in cotton industry nor exposed to cotton dust. Information was collected using standardized questionnaires, physical examination and spirometric measurements. Student's T test was usedto find the difference between spirometric parameters. All the respiratory parameters  were reduced in cotton industry workers as compared with control subjects (p<0.0001) and no significant differenceof SpO2 between groups. Cotton dust exposure makes huge impact on respiratory parameters of the cotton industry workers. This deterioration in respiratory health deteriorates with increasing duration of exposure. The health hazards caused by cotton dust shouldbe controlled by creating awareness among the workers & employers. Byssinosis is a crippling occupational lung disease caused by cotton dust. It is a well known occupational respiratory disease among cotton mill workers induced by cotton dust pollution. Byssinosis also called Brown Lung or Brown Lung disease is a typeof Pneumoconiosis caused by dust from cotton fibers. Inhaled dust stimulates histamine release which causes constriction of the air passages, making breathing difficult over time. Inhalation of the dust particles depends on its aerodynamic diameter, surroundingair's velocity, and breathing rate of the person. The inhaled fine cotton dust particles would get sedimented in the gas-exchange part of the lung tissue, where air flow is slow. These fine particles get lodged in the respiratory bronchioles within the centralpart of the acinus. The duration of exposure to cotton dust, type of dust, concentration of dust and the size of dust particle influence the effect on lungs . The preThe present study was conducted in department of physiology, Nootan Medical College & research Centre, Sankalchand Patel University, Visnagar, Mehsana district. This study composed of two groups which contains totally 100 subjects. Group A(Study group) comprises 50 Female workers of cotton industry. The workers were selected from different cotton textile industries of Mehsana district. Group B (control group) comprises 50 age matched females who were neither worked in cotton industrynor exposed to cotton dust. Female subjects of cotton industry, relatives of patients attending various outpatient departments in the age group of 18 - 40 years, who come forward for the study voluntarily and satisfied the inclusion criteria, wererecruited. Subjects on medication for Cardiovascular respiratory illness and Central nervous system (CNS) disorders, subjects with past and present history of CVS disorders, diabetes, psychiatric illness, subjects with history of drug abusing,smoking were excluded.A elaborate clinical history of these volunteers were taken such as relevant past history, family history, drug history, personal history like alcoholism, smoking etc. A structured questionnaire was given to all volunteers (subjects) to obtain the detailsof occupational history and history of past or present respiratory illnesses. The present study was approved by the Institutional ethics committee  and an informed consent was taken from all the subjects after explainingthe test procedures and the goal of the study in local language. The anthropometric measurements such as height, weight, Body mass index (BMI), body surface area (BSA), lean body mass (LBM), Fat % were recorded for each subject by using standard procedure[7 - check with author]. SpO2 (Oxygen saturation) was measured with a digital handheld pulse oximeter  to investigate oxygen saturation (blood oxygen level) in blood. Participants rested at least15 minutes before examination of SpO2. PFT was done with the help of spirometer (RMS Helios 401). The following variables were evaluated for spirometry: FVC (L) , PEF (L/S) (Peak expiratory flow), FEF 25-75% (Forced expiratory flow),FEV1 (L) (Forced expiratory volume in first second of FVC), MVV (Maximum voluntary ventilation), and FEVI/FVC (%). The subjects were briefed about the procedure of conduction of spirometry and demonstration was given before initiation of procedure. The subjectswere instructed to take deep inspiration from outside and then to expire as forcefully and as fast as she can inside the mouthpiece and recorded the activities. Using all aseptic techniques, the pulmonary function tests were conducted on subjects in standingposition and wearing nose clips. Each test was repeated three times and the best results among the three were considered for analysis. Experiments were done in accordance with revised Helsinki Declaration of 2000.Statistical analysis was performed with SPSS  (version 17.0). Results are expressed as mean ± standard deviation (SD) and assessed using Student's t-test. P-value < 0.05 was considered statistically significant.Table 1(see PDF) describes baseline (anthropometric) characteristics of the subjects. It can be seen that majority of the subjects were adults and all the subjects were females. There was no significant difference between the two groups (control & studygroup) in terms of anthropometric measures. Table 2(see PDF) describes the lung function parameters (Spirometry) of study and control group subjects. All the respiratory parameters  were reduced significantlyin cotton industry workers as compared with control subjects (Group B) (p<0.0001). The mean predicted values of FEV1 and FVC parameters were reported in Table 1(see PDF). Predicted value of FEV1 in study subjects were decreased significantly (p<0.0466),predicted FVC value was also decreased in study group however it was not statistically different (p<0.0802). The prevalence of various respiratory symptoms was shown in Table 2(see PDF) and the most common finding was reported is dyspnea followed by chesttightness & cough (16% & 20% respectively). No such symptoms were noted in control group (Group B). Figure 3(see PDF) shows Mean value of SpO2 (Oxygen saturation) in study and control groups. No significant difference of SpO2 between study and controlgroups (p<0.6612). Table 3(see PDF) shows duration of Cotton dust exposure among cotton industry workers. In the present study majority of the subjects had an exposure of at least 10 years or more showing an increased risk of developing lung diseases relatedto byssinosis.Women working in the cotton industry are more susceptible to various health problems much to their counter parts in other sectors. In the present study the anthropometric parameters of study and control group showed no significant difference thus makinggroup comparable. In the present study, Forced vital capacity (FVC) was significantly decreased in cotton industry workers. This is supported by a report of Fishwick and Jadhav A.J et al ,9.StudiThe Present study showed a strong coalition between cotton dust exposure in the cotton industry environment and lung function abnormalities. The pulmonary parameters are decreased significantly in the subjects working in cotton industry. This suggeststhat more aggressive measures must be taken in the workplace and enforcing the use of personal protective equipment, such as respirators and face masks. The health hazards caused by cotton dust should be controlled by creating awareness such as regular healthcheck-ups, personal protective measures and proper ventilation among the employees & employers and thereby ensuring the quality of life of the cotton textile industry workers.


The links between body image disturbances and distorted relationships with parents were supposed since the early conceptualizations of AN by Hilde Bruch. The empirical studies however were concerned with perceptual aspects of body image and much less is known about how the attitudinal aspects and the body-related behaviors are affected.To study the attitudinal and behavioral aspects of body image in adolescents with AN in relation to perceived parental care and the attachments to close people.The Body Investment Scale (BSI), Parental Bonding Instrument (PBI) and Attachment Style Questionnaire (ASQ) were used. 53 girls with Anorexia Nervosa were compared to 63 controls (adjusted by age).Girls with AN scored significantly higher on BIS Body attitude (p<.001) and Protection scales (p<.01), while displayed equal results on Body Care scale. They displayed lower Confidence in relationships (p<.01), higher Need for approval, Discomfort and preoccupation in close relationships (p<.05). No differences were found on PBI, excerpt for AN group perceiving less paternal control (p<.05). The correlation analysis, while showing a number of similar correlations within groups, suggests that in AN group positive Body image was more closely linked to perceived early care, especially from father (r=.6), in contrast with controls. In current relationships negative Body image for AN is stronger related to Discomfort and Need for approval (r>0.6), while Discomfort with Touch is less linked to problems in relationships than in controls.Results suggest the importance of studying the father’s mediating role in the formation of body attitudes in AN.No significant relationships.


Perceived control is an important psychosocial resource for healthy aging. Using data from the National Study of Daily Experiences , we examined aging-related changes in stressor control across 10 years and compared these trajectories with measures of general control . Over 8 consecutive days in waves conducted in ~2008 and ~2017, people reported their perceived control over four types of stressors . Longitudinal analyses revealed declines in stressor control across 10 years (p<.001), driven by declines in home stressors specifically. The rate of decline did not depend on baseline age. General control trajectories showed unique patterns of age differences in aging-related change such that declines  were steeper among older adults (p<.001). Results suggest that stressor control is a distinct domain of control beliefs with aging-related declines that differ based on type of stress experienced.


Growing evidence has shown that genetic factors play crucial roles in the disorder of eye development and the progression of ocular diseases . Ocular The eye consists of three main types of tissues: 1) refracting tissues that focus incoming light onto light-sensitive tissues , 2) light-sensitive tissues that convert detected light into electrical signals and transmit them to the brain (including the retina and optic nerve), and 3) support tissues that provide the architectural support for the shape of the eyeball  . These pThis topic summarizes ten original research articles that explored the genetic effects and mechanisms of genetic factors contributing to eye development and disease from diverse aspects, providing new insights into treating eye diseases . AccordiInherited eye diseases affect approximately one in 1,000 people worldwide, but the molecular mechanisms underlying most of them remain unclear . IdentifWei et al. identified mitochondrial mutations (OPA1 and LHON-mtDNA) in nearly half of patients with ethambutol-induced optic neuropathy (EON), a well-recognized ocular complication associated with ethambutol treatment in tuberculosis patients. Since some patients with EON have severe and permanent visual loss even without the known risk factors, their findings that mitochondrial genetic variations are major predisposing factors for the development of EON provided a better understanding of EON and additional support for genetic counseling.Zhang et al. found variants in BMP4 contribute to a novel phenotype of pathologic myopia rather than syndromic microphthalmia that have been reported in a previous study  , the second leading cause of pediatric lens surgery after congenital cataracts, could be caused by mutations in cbEGF-like domains of fibrillin-1 (FBN1) . HoweverLuo et al. presented work on the role of the mouse double minute 2 (MDM2) gene single nucleotide polymorphism (SNP) T309G in the development of epimacular membranes (EMMs), relatively common sight-threatening conditions characterized by fibrocellular proliferation along the surface of the internal limiting membrane (ILM) of the retina. They first reported that the MDM2 SNP309 G allele was a risk allele for EMM in a Chinese population. Their observation provides new insights into the molecular mechanism underlying these pathologies.Since the experimental studies of many inherited eye disorders in human beings are limited, the availability of genetically engineered animal models is very valuable for exploring the pathogenic mechanisms of these conditions and developing translational therapies.Zhao et al. generated a knock-in mouse model with lanosterol synthase (Lss) G589S mutation, which can recapitulate human congenital cataract resulting from G588S mutation in human LSS. Mice with homozygous Lss G589S mutation exhibited disrupted lens fiber differentiation at early-stage of lens development and down-regulated cholesterol synthesis signaling pathways. Their findings elucidate the important roles of LSS in lens development, contributing to a better understanding of LSS defects and disturbed sterol signaling in cataractogenesis and the development of therapies for cataracts.Hejtmancik et al. generated and characterized the Kcnj13 knockout mouse and RPE-specific conditional Kcnj13 knockout mice. Their work provides a potential mouse model system for elucidating the pathology of these diseases and developing gene therapy trials.Mutations in KCNJ13 are responsible for both snowflake vitreoretinal degeneration (SVD) and Leber congenital amaurosis (LCA) . ExistinASRGL1) has been reported as a causing mutation for retinitis pigmentosa (RP), an inherited retinal degenerative disease for which there is currently no cure  could be reprogramed into functional retinal ganglion cells (RGCs) in vivo by Math5 and Brn3b together, two crucial transcription factors (TFs) involved in retinal ganglion cell (RGC) generation and differentiation  and the optic nerve are the common features shared by all forms of glaucoma . In vivontiation . Their sHou et al. profiled a single-cell transcriptome atlas of human RPE (hRPE) cells and provided a map of disease-related genes in the hRPE. They found two subpopulations, the macular RPE and peripheral RPE clusters which exhibited substantial differences in gene expression patterns and functions, play crucial roles in the potential treatment of retinal diseases. Their work provides important information for understanding the cellular mechanisms and treating pathological conditions of the hRPE associated with ocular diseases.These research articles on the topic show that elucidating the genetic underpinnings of ocular disorders leads to a better understanding of these diseases, which will contribute to clinical diagnosis, genetic counseling, early intervention and targeted treatment. The application and advancement of integrated multi-omics will further improve our knowledge of complex traits and provide new insights into the pathogenesis of ocular diseases. New genetic methodologies based on automated methods are expected to be developed for accurate and routine diagnosis of eye diseases that have highly diverse genetic causes and are difficult to identify. And gene and cell therapies will open new doors for the treatment of currently incurable eye disorders.


Chronic functional gastro-intestinal disorders can affect cognitive functioning of patients (1). Wong et al (2) showed attentional and executive function impairment, Aizawa et al. (3) found impairment of cognitive plasticity and activity of frontal and temporal arias of brain during performing tests in these patients.Assessing of cognitive functioning of the female patients with chronic functional constipation.42 Rome IV adult female patients with chronic functional constipation and 26 adult normative female volunteers were tested with Brief Assessment of Cognition in Schizophrenia (BACS).Both groups were comparable by age  In both groups subjects demonstrated normal level of cognitive functioning but the scores of the patients were closer to the lower level than the scores of the volunteers. The difference was significant in composite scores and in several other scores (Tab.1). Table1.The findings of the study once more indicate some link between gastrointestinal dysfunction and cognitive functioning. Even these slight decrease in some aspects of cognition from normal population could have negative impact on everyday functioning. The origin of this link is still under question.No significant relationships.


Mapping positional features from one-dimensional (1D) sequences onto three-dimensional (3D) structures of biological macromolecules is a powerful tool to show geometric patterns of biochemical annotations and provide a better understanding of the mechanisms underpinning protein and nucleic acid function at the atomic level.We present a new library designed to display fully customizable interactive views between 1D positional features of protein and/or nucleic acid sequences and their 3D structures as isolated chains or components of macromolecular assemblies.https://github.com/rcsb/rcsb-saguaro-3d.Bioinformatics online. Mapping positional features from 1D sequences onto 3D structures of biological macromolecules facilitates interrogation of relationships between shape and function. Sequence to structure mapping enables identification of spatial correlations and geometric patterns among protein or nucleic acid annotations that would be obscured if they were analyzed solely using linear polymer sequences. Over the last few years, various libraries, web applications and software tools have been developed to compute alignments among structures, and protein and gene sequences, and visualize positional features over the different levels of molecular organization from genome to macromolecular assemblies. 3DBIONOTES  annotatiIn this work, we present a new TypeScript/JavaScript module designed to create custom interactive views between 1D sequence positional features and 3D structures of macromolecules over the web. The main motivation behind this development is to provide the structural bioinformatics community with a flexible and fully customizable tool that can be adapted for use in various contexts. To achieve this end, the library exposes multiple event callbacks that allow software developers to define bidirectional interactions between 1D positional features and 3D atomic coordinates of experimental structures (from PDB) or computed structure models ; the US Department of Energy [DE-SC0019749]; and the National Cancer Institute, National Institute of Allergy and Infectious Diseases and National Institute of General Medical Sciences of the National Institutes of Health [R01GM133198] .Conflict of Interest: none declared.btac317_Supplementary_DataClick here for additional data file.


Oesophageal cancer survivorship is afflicted by cancer cachexia related weight loss and nutrition impact symptoms. Identifying the factors which predict cancer cachexia specifically is warranted in order to identify those at risk and render the right kind of support. We aimed to assess if preoperative and postoperative body mass index (BMI) adjusted weight loss grading system (WLGS) is predictive of cancer cachexia at one year after surgery for oesophageal cancer.p < 0.05 together with a clinically relevant difference of 10-points in mean scores was considered as a significant difference.Data were used from a prospective nationwide cohort study on patients operated on for oesophageal cancer in Sweden between 2013 and 2018 included at one year after surgery. The study exposure is BMI adjusted weight loss graded into one of five distinct weight loss grades (grades 0–4), defined in accordance with the WLGS by combining BMI and percentage weight loss, assessed at two clinical time points: preoperative and at 6 months post-surgery for oesophageal cancer. The study outcome is subjective measures of cancer cachexia one year after surgery, assessed using the cancer-cachexia specific questionnaire EORTC QLQ-CAX24. Multivariable linear regression models calculated mean score differences (MD) with 95% confidence intervals (CI) adjusted for predefined confounders. Statistical significance at Among a total of 232 patients, the highest grade of preoperative WLGS 4 was associated with significantly worse physical decline than lower grades of WLGS 1  and WLGS 2 . Those with preoperative WLGS 2, 3 and 4 reported lower scores on the adequacy of information on weight loss provided to them than those with preoperative WLGS 0. Those with the highest postoperative WLGS 4 had greater eating and weight loss worry than WLGS 2  and WLGS 3  and worse physical decline than WLGS 0 .Higher grades of both preoperative and postoperative WLGS are predictive of cancer cachexia related physical decline one year after surgery for oesophageal cancer. Additionally, preoperative and postoperative WLGS were also predictive of inadequate information concerning weight loss and more worry regarding eating and weight loss, respectively. The WLGS may be an effective risk prediction tool for postoperative cachexia related physical decline in patients undergoing treatment for oesophageal cancer emphasizing its usability in the clinical setting. Despite improving survival rates with multimodal treatments such as chemotherapy and radiotherapy, an extensive surgical procedure remains the cornerstone of curatively intended treatment for oesophageal cancer , 2. CancOesophageal Surgery in Cancer patients: Adaptation and Recovery (OSCAR) cohort, a nationwide and prospective study of patients who were operated on for oesophageal cancer in Sweden from 2013. The data collection for the OSCAR study is ongoing. The OSCAR study is explained in detail elsewhere . Th. Th14]. n) and proportions (%). Multivariable linear regression models were used to calculate the association between preoperative and postoperative WLGS and the cachexia scale scores from QLQ-CAX24. A linear model was used since a pre-established cut-off is not available for cachexia scores and mean scores difference (MD) of 10 or more points (10%) were tested for statistical significance. A 10-point difference was regarded as clinically relevant based on previous research [Descriptive statistics were presented as counts , age at operation (continuous), comorbidities (Charlson comorbidity score 0/1/≥2), histological sub-type (adenocarcinoma and high-grade dysplasia/squamous cell carcinoma), pathological tumour stage (0-I/II/III-IV) and neoadjuvant therapy (yes/no). For the postoperative WLGS at six months after surgery in addition to the above confounders, type of operation , postoperative complications (Clavien-Dindo score (CDS); low grade (0-II)/high grade (III-IV), enteral and/or parenteral nutrition support for at least 1 week postoperatively (yes/no) was adjusted for. Statistical analysis was conducted using SAS 9.4 software .n = 25) or other reasons (because they did not want/had the energy to participate (n = 119), were too sick (n = 28), other reasons (n = 1)). In total, 253 (58% of eligible) completed the EORTC QLQ-CAX24 questionnaire, and 232 had complete data concerning WLGS before operation and clinical data from medical charts, hence were included in the analysis.Between January 2013 and 15 May 2019, a total of 839 patients underwent surgery for cancer of the oesophagus in Sweden. Of those, 636 patients were alive at the one-year follow-up, 113 were unreachable and one patient was excluded owing to cognitive impairment, leaving a total of 522 patients eligible for inclusion in the OSCAR cohort and 438 eligible for the current study as 84 were included in the cohort before the EORTC QLQ-CAX24 questionnaire was introduced. Among those identified as eligible, 173 (39%) declined to participate for reasons namely, cancer recurrence  had a higher comorbidity score than those in the other categories of WLGS 1–4 (15.1% to 23.1%). More patients (43.5%) with WLGS 4 had a higher pathological tumour stage (III-IV) than those with the least WLGS 0 (31%). As many as 91.3% of patients in the WLGS 4 received enteral or parenteral nutrition support compared to 77.5% in the WLGS 1  from the five weight loss grades were reported in the eating and weight loss worry dimension MS 30 to 38) and food aversion dimension (MS 28 to 34) [Table 0 to 38 aAmong the dimensions of the QLQ-CAX24 as per the five grades of postoperative WLGS at six months after surgery, the highest MS were reported in the eating and weight loss worry dimension MS 21 to 38) and food aversion dimension (MS 21 to 33) [Table 8 and fooThis population-based prospective cohort study on patients who underwent surgery for oesophageal cancer, exploring if the WLGS is a predictor of long-term cancer cachexia indicated that higher grades of both preoperative and postoperative WLGS are associated with cancer cachexia related physical decline at one year after surgery for oesophageal cancer. Additionally, higher grades of preoperative WLGS were also associated with inadequate information on weight loss aspects of cancer cachexia. Meanwhile, higher grades of postoperative WLGS was also predictive of eating and weight loss worry among patients. The results signify that the WLGS maybe a useful predictor of specific cancer cachexia related decline in oesophageal cancer patients.Several methodological aspects in the present study add to its strength. The population-based nationwide data collection with a longitudinal design minimised selection bias and increased generalisability of the results. The OSCAR cohort is comprised mostly of male patients, which is typical for oeophageal cancer and hence considered representative of the disease demographics and generalisable. Adherence to a strict protocol for data collection further reduced the scope for bias, and another added strength is the unique home-based data collection which reduced missing values. However, selection bias through non-participation of those who were unreachable and declined participation in the study cannot be neglected and may be considered a potential limitation. The choice of the WLGS as the assessment tool for the exposure and EORTC QLQ-CAX24 for the assessment of the outcome is also a strength in the present study. The WLGS has marked a crucial step in redefining clinically important weight loss where BMI is included and has thus been included in the current international clinical practice guidelines for nutrition and cancer . MoreoveIn our study, both the higher grades of preoperative and postoperative WLGS was predictive of physical decline at one year after surgery for oesophageal cancer. In the treatment of patients with oesophageal cancer, resection surgery remains the cornerstone of curatively intended treatment . The surOur results highlight that the WLGS may be a good risk prediction model for the cancer cachexia related physical decline in patients undergoing treatment with oesophageal cancer emphasizing its usability in the clinical setting. The persisting and long-term issues concerning eating and weight status are also a major challenge for health care and the WLGS is a more clinically relevant and robust tool for cachexia related physical decline after surgery for oesophageal cancer.Table S1Table S2


Night work has been widely studied for the associations with diseases, sickness absence (SA) and disability pension (DP), but less for sustainable working life. We aimed to investigate the longitudinal changes in sustainable working life among those with or without baseline night work.Using data from Swedish national registers, sustainable working life was defined as employment during follow-up without interruptions due to SA/DP, unemployment, and old-age pension. Survey data for two cohorts  were utilized to assess night work at baseline (yes/no) in 1998-2003 and 2004-2006, respectively. The final samples for the two cohorts were 34680 and 19637, respectively. Group-based trajectory models were applied.Among those born before 1959 , a five-trajectory solution was best for those with and without night work. The trajectory groups were stable sustainable working life (38-42%), stable unsustainable working life (24-25%), early (13%) or later (13%) decreasing sustainable working life, and between sustainable and unsustainable working life (7%). Among those born after 1958 , four trajectories were detected for those with night work: stable sustainable working life (81%), stable unsustainable working life (6%) and increasing (7%) and decreasing (5%) sustainable working life. For those without nightwork, a three-trajectory solution was best: stable sustainable working life (83%), stable unsustainable working life (6%) and between sustainable and unsustainable working life (11%).Sustainable working life was similar across baseline night work statuses of older cohort but differed in younger cohort. The findings suggest that at least night work at one time point does not affect sustainable working life. However, night work at early stages of working life could be accompanied with lifestyle counselling for sleep and recovery.• Trajectories of sustainable working life seem similar for those with or without night work adding to the understanding of effects of such work to health.• From public health perspective, counselling employees with night work already at early stages of working life for health behaviours including sleep and recovery could support sustainable working life.


This review describes the recently FDA-approved drugs (in the year 2022). Many of these products contain active moieties that FDA had not previously approved, either as a single ingredient or as part of a combination. These products frequently provide important new therapies for patients with multiple unmet diseases. The diverse small molecules are described according to the date of approval and their syntheses is discussed. This review comprises classical chemical scaffolds together with innovative drugs such as a deuterium-containing drug. The constant research for innovative therapies leads every year to molecules that are approved by the United States Food and Drug Administration (FDA), a federal agency of the U.S. Department of Health and Human Services.Novel building blocks and their connections have been explored much in recent years allowing drug hunters to explore a much bigger chemical space .Small molecule drugs are organic compounds with low molecular weight. For a long time, they have been the backbone of the pharmaceutical industry. There are several benefits that make small molecules important drugs in therapy, such as the possibility of oral administration and cell membrane permeability which allow them to reach specific tissue and targets. For this purpose, small molecule drugs can be designed in order to acquire, for example, specific affinity and selectivity  .The goal of this review is to highlight the chemical entities approved in the year 2022 for clinical use. The approved drugs (and their synthesis) are listed according to their chronological approval date . This pa11) (brand name Quviviq®) is a 1,2,3-triazole derivative with an expected global sales to 2026 of $1052 million pyrimidine 14  in the presence of diisopropylethylamine (DIPEA) to give the intermediate 15 which underwent the deprotection of carboxylbenzyl protecting group under acidic conditions (HBr) to afford 16. The free primary amino group of 16 reacted with the propane-1-sulfonyl chloride 17 to provide the sulfonamide 18. The last stage (yield: 74%) involved the removal of tosyl group by using lithium hydroxide or sodium hydroxide in ethanol to generate Abrocitinib (19).Approved in January 2022 (14 January 2022), abrocitinib  was approved for the treatment of hereditary hemolytic anemias  sta sta16] s41) was authorized for the treatment of seizures in cyclin-dependent kinase-like 5 deficiency disorders  to provide PSMA-617 (52).Its structure is composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium, Lu 177 (177Lu) . The syn177Lu) ,23. The 67, brand name Vivjoa®) was approved in April 2022 (26 April 2022) with the indication of reducing the incidence of recurrent vulvovaginal candidiasis (RVVC) in females with a history of RVVC who are not of reproductive potential [The antifungal oteseconazole  at −65 °C to afford derivative 57. The following Henry reaction provided the mixture of nitro alcohols 59  and 60 (S enantiomer of 59) in the presence of 5% mol of organocatalyst 58. The enantiomeric ratio of the couple 59:60 was 90:10. The organocatalyst 58 proved to be the most effective in stereoselectivity among the many others tested. The subsequent catalytic hydrogenation  of the mixture of nitro alcohols led to the corresponding amines 62 and 63. The conversion of 62 and 63 to the corresponding tetrazoles 64 and 65 was mediated by trimethylsilyl azide and trimethyl orthoformate in the presence of acetic acid. The last step involves a Suzuki coupling between the aryl bromide of 64 and 65 and the boronic ester 66 catalyzed by (diphenylphosphino) ferrocene] dichloropalladium (II) to generate the desired oteseconazole 67. The authors claim that an enantioenriched (95.9%) form of 67 was obtained via diastereomeric recrystallisation with (S)-Camphor sulfonic acid  ,26 25,26®) was approved in April 2022 (28 April 2022) for the treatment of certain classes of obstructive hypertrophic cardiomyopathy [Mavacamten  which upon reaction with trimethylsilyl isocyanate 70 is converted to isopropylurea 71. The reaction between 71 and dimethyl malonate in the presence of sodium methoxide as base gave 1-isopropyl barbituric acid 72. The subsequent conversion to chloride derivative 73 is mediated by POCl3 using triethylbenzylammonium chloride (TEBAC) as phase transfer catalyst. The last stage is the nucleophilic addition of (S)-methylbenzylamine (74) to 73 in order to afford mavacamten 75. Last step yield was 69% [Its synthesis  29] sta sta29] s®) was approved in May 2022 (3 May 2022) for the treatment of Helicobacter pylori infection  sta sta35] s®) was approved in September 2022 (9 September 2022) and for the treatment, as in the case of tapinarof, of plaque psoriasis [Deucravacitinib (brand name Sotyktusoriasis . It is esoriasis .It is a deuterated drug launched by Bristol Meyers Squibb  selectiv89 which is firstly methylated with methyl iodide and later converted into amide by ammonolysis to afford the intermediate 90. The treatment of 90 with DMF-DMA followed by condensation with hydrazine hydrate yielded the triazole 91 which was then methylated in presence of methyl iodide and potassium hexamethylsilazide to generate compound 92 in a good regioselectivity (8:1) over compound 93.Its synthesis  38] sta sta38] s92 was subjected to catalytic hydrogenation  to give the substituted aniline 94 which was then mixed with the pyridazine 95  and aqueous potassium triphosphate resulted in a better yield and milder conditions if compared to the triad XantPhos/Pd2(dba)3/Cs2CO3. Last step yield was 76%.Pure compound azine 95  in the pApproved in September 2022 (21 September 2022), gadopiclenol is used to detect and visualize lesions, together with Magnetic Resonance Imaging (MRI), with abnormal vascularity in the central nervous system and the body  ori ori42] o® dichloropalladium (II)] between halide 124 and alkyne 125 provided the derivative 126. The subsequent nucleophilic attack (resulting in inversion of configuration) of 126 to mesyl-protected alcohol 127 afforded the pyrrolidine derivative 128 which was subjected to BOC-removal by addition of HCl to give 129. The final step involves another nucleophilic attack (acylation) of 129 to acryloyl chloride (130) followed by neutralization with sodium bicarbonate to yield futibatinib (131).Its structure contains a pyrazolo-pyrimidine scaffold and the synthesis  53,54] ,54 53,54Sulfonamide-containing drugs (four entities) are arising among the approved molecules in 2022. Sulfonamides were among the first examples of carboxylic acid isosteres to show utility in drug design .®, In the previous year (2021), only odevixibat (brand name Bylvay19), a pyruvate kinase enzyme activator , a potassium-competitive acid blocker (P-CAB) represented by vonoprazan  and a selective prostaglandin E2 receptor agonist . None of these molecules  in the synthesis of folic acid which is essential for the further production of DNA in the bacteria [Historically, the first sulfonamide drug was prontosil rubrum . This cobacteria . Anotherbacteria .Interestingly, none of the sulfonamides approved by FDA in 2022 belong to the last two groups of inhibitors, creating novel opportunities in hitting novel and diverse targets.Moreover, a key-feature that would help in the design of novel bioactive compounds is the fact that sulfonamides possess high hydrolytic stability .In this work, all small molecule drugs that were approved by the FDA in 2022 were discussed. For each compound, the biological activity and the chemical synthesis were provided. It appears that sulfonamide-containing drugs are dominating the year 2022 with four molecules approved. Their physicochemical and pharmacodynamic properties still play an important role many years after the discovery of the first sulfonamides endowed with antibacterial activities.Deuterium-containing drug deucravacitinib represents, on the other hand, an example of novel approaches in drug discovery incorporating an unusual isotope to provide drug stability.The discovery of pyrimidinedione mavacamten for the treatment of cardiomyopathy and the huge forecasted sales  for thisThe combination of drugs, for example vonoprazan (in combination with amoxicillin and clarithromycin) and taurursodiol (in combination with sodium phenylbutyrate) is still a valid weapon for the treatment of unmet medical diseases.The 15 FDA-approved small molecules  in 2022


Sphenoid sinus mucocele (SSM) caused by obstruction of sinus ostium while sphenoid sinus retention cyst (SSRC) is due to obstruction of mucinous gland ostium which could enlarge to obstruct the sinus ostium and lead to acute sinusitis or mucocele,Incidence of isolated SSM is about 2% out of paranasal sinus (PNS) mucocele, but there is no specifically occurrence rate regarding SSRcWe herein describe one case of SSM and two cases of SSRC with sudden unilateral visual loss that recovered following endonasal endoscopic sinus surgery.A 25-year-old man with left-sided vision loss (light perception (LP), afferent pupillary defect (APD)) occurred within 24 hours, was referred after 10 days of the attack.Magnetic resonance imaging (MRI) showed a mass with rim enhancement obstructing the sphenoid sinus ostium . ComputeA 12-year-old boy with a history of gradual visual loss of left eye over 2 month-period was referred because of left sphenoid sinus mass in MRI with no Gadolinium uptake that was compatible with SSRC. There was no obvious compression of the optic nerve in the CTS or MRI .(28-year-old woman) showed up with total visual loss (LP and APD) of the right eye over 34 day period and retro-orbital pain. She had a similar attack 4 years earlier treated with 2-week administration of Dexamethasone. MRI showed an RC in the sphenoid sinus  touchingAll patients were referred by ophthalmologist with the first diagnosis of retrobulbar optic neuritis (RON) following incomplete recovery with administration of glucocorticoids. The patients underwent endoscopic endonasal approach and the cysts were removed. Total vision and visual field recovery were achieved in case 1 and 3 and partial recovery in second case.Isolated inflammatory diseases of SS are infrequent comparing to other paranasal sinuses. However neglected sphenoiditis could lead to critical complications by affecting adjacent vital structures such as cranial nerves II, III, IV, VIVisual loss and blindness often occur following circulatory disorders of the optic nerve caused by prolonged mucocele pressure that erode the bone and put the nerve in jeopardyMucocele could show four patterns of MRI signal intensity according to the protein concentration revealing its chronicityA high index of suspicion is needed for proper diagnosis of this entity especially for neurologists and ophthalmologists who are usually first physicians visiting sudden visual loss cases.


Scientific Reports 10.1038/s41598-022-10708-9, published online 05 May 2022Correction to: The original PDF version of this Article contained errors in the Results section under the subheading ‘Pulse width’, where the confidence intervals of the median relative perception thresholds The confidence intervals of the median relative attention thresholds The confidence intervals of the median relative intolerance thresholds Table 2 shows the results of linear regression The original PDF version of this Article has been corrected.


The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) showed the benefits of blood pressure (BP) lowering for secondary stroke prevention in stroke survivors for the first time after a long dispute in the last century  and trigIn the present post hoc analysis of RESPECT, Kitagawa et al. examined the effect of intensive BP lowering on recurrent stroke subtype risk in patients with a history of ischemic stroke, accounting for 84% of the overall participants in RESPECT . The majAnother major finding of the RESPECT sub-analysis was that the risk of recurrent ischemic stroke was almost identical between two treatment groups with different BP lowering targets . The uncAs the adverse events of intensive BP lowering, the authors of the RESPECT sub-analysis indicated caution regarding falls and renal dysfunction . Acute kThe current guidelines recommend systolic BP control aiming at <130 mmHg or 120–130 mmHg for adults who experience ischemic stroke –12. RESP


Drawing on the life course perspective and multi-channel sequence approach, this research identifies long-term financial hardship and income security patterns among older adults and examines their relationship with depressive symptoms. Data were from the 2010 to 2018 HRS with 3,077 older workers aged 62–71 in 2010. Four clusters of key sequences were identified: 1) High food and low medical insecurities with private pension plans (43%); 2) Moderate food and low medical insecurities with gradually acquired private pension plans (13%); 3) High food and low medical insecurities with both private and employment-based pension plans (40%); 4) High food insecurity with employment-based pension plans(3%). Regarding the association with depressive symptoms, a group of people who experienced high food and low medical insecurities with private pension plans  and those who experienced moderate food and low medical insecurities with gradually acquired private pension plans  were more likely to have depressive symptoms compared to those high food and low medical insecurities with both private and employment-based pension plans. These findings highlight the heterogeneity of long-term patterns of financial hardships and patterns of income security, including the limited accessibility for a pension plan through their occupation and that an individual pension plan may not be sufficient to ensure mental health in later life. The results imply the importance of dual security of private and employment-based pensions on their mental health and provide important insights for future tailored income support programs for older adults.


Alzheimer's disease (AD) is the most common dementia syndrome in the elderly and a devastating neurodegenerative disease without any cure available currently. AD patients usually present insidious onset and progressive cognitive impairments with unique post-mortem diagnostic brain pathology including accumulation of amyloid beta (Aβ) and hyper-phosphorylated tau proteins  and highlights both basic and clinical studies in the relevant field. In total, seven original research articles from investigator groups across the world using multiple state-of-art scientific approaches reported AD- or ADRD-related metabolic signaling alterations in rodent models or human subjects.The current Research Topic “Zhao et al.) analyzed plasma metabolites profile in the MCI patients by using a high-resolution mass spectrometry metabolomics approach. The results indicate an association between dysregulated sphingolipid metabolism and behavioral performance in the MCI patients, providing insights into development of novel blood biomarker for MCI.The Qi Guo group  examined the relationship between AD polygenic risk score (PRS) and longitudinal decline of cognition function in older adults with type 2 diabetes (T2D). Interestingly and contrary to the authors' hypothesis, the analysis revealed no significant association between the AD PRS and multiple measurements in older adults with T2D such as cognitive decline, hippocampal volume, and Aβ burden. Their findings indicate a complex relationship between AD genetic susceptibility and cognitive impairments in T2D.The Lior Greenbaum group  reported that global knockout of the mRNA translation factor eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) led to improvement of cognitive function in a mouse model of AD without affecting the brain Aβ pathology. The study provides further evidence to suggest that targeting eEF2K signaling dysregulation might be a feasible therapeutic approach for ADRDs.The laboratory of Tao Ma  biometric components and the gray matter volume (GMW) in different brain regions. They found that decreased GMV across all the examined brain regions in the MetS patients is correlated best with waist circumference. Surprisingly, posterior cerebellum is the brain region mostly correlated to the MetS biometric components.Weise et al. analyzed the data of the MCI participants from the AD Neuroimaging Initiative (ADNI) study and reported a correlation of higher body mass index (BMI) with greater regional cerebral metabolic rate for glucose (rCMGgl) and slower cognitive decline in MCI. Such association is not related to leptin levels. Future studies are necessary to illustrate the mechanisms underlying such correlations between brain glucose utilization and body weight.Smith et al.) reported their unexpected findings revealing novel roles of the AD risk gent Abelson interactor family member 3 (Abi3) in metabolism. They found that the Abi3 knockout mice exhibited impaired energy expenditure, increased body weight and body fat, and impaired glucose tolerance and insulin sensitivity. The study may contribute to our understanding of the metabolic factors in AD development.The laboratory of Jungsu Kim (Kurano et al. examined postmortem human brains to understand potential association of the bioactive lipid regulation with the AD pathology. The study showed distinct pattern of bioactive lipid modulation correlated to AD pathogenesis.Frontiers in Aging Neuroscience is to increase overall interest in this under- investigated area of research and bring investigators from both basic science and clinical research fields. We are encouraged and excited by the findings reported in these articles and look forward to future in-depth studies on the topic to facilitate our underlying of the mechanisms underlying aging and ADRDs.In summary, accumulating evidence indicates a link between metabolic signaling dysregulation and cognitive impairments associated with aging and Alzheimer's disease. An important goal of this Research Topic in TM wrote the manuscript. RC and SM edited the manuscript. All authors contributed to the article and approved the submitted version.


Many elder abuse interventions and tools designed to screen for abuse exclude older adults with cognitive impairments (CI) due to the challenges associated with screening and whether the older adult with CI can reliably report elder abuse. However, it has been shown that older adults with CI are among the most vulnerable to experiencing elder abuse. VOICES is an innovative, automated tablet-based elder abuse screening and prevention intervention that is self-administered by the older adult in the provider’s waiting room or office. The VOICES Elder Abuse Intervention (EAI) provides screening, educational modules, and brief psychoeducational intervention to enhance and improve identification of elder abuse when there are no visible signs of abuse. The VOICES EAI was already proven successful in terms of feasibility and acceptability in cognitively intact older adults in a busy emergency department setting with . In this study we tested the VOICES EAI with (N=30) participants 60 and above with cognitive impairment at a geriatric center using the Montreal Cognitive Assessment (MoCA) to determine cognitive capacity. Experts in the field of geriatrics and cognitive impairment assisted in grouping participants within three cognitive categories: Mild cognitive impairment (MoCA 23-25), mild dementia (MoCA 16-22) or moderate dementia (MoCA 8-15). Of the (N=30) participants, 29 were able to successfully use the VOICES EAI independently, and most participants were satisfied with the tool. We will discuss the findings of this preliminary study and the implications for future research with older adults with CI.


The advent of the SARS-CoV-2 virus necessitated behavior changes for most older adults. Changes were largely associated with voluntary or enforced compliance with social distancing policies. Whereas the value of social distancing for mitigating the spread of the dangerous SARS-CoV-2 virus is not the subject of serious debate among public health advocates, policies that encouraged or enforced social distancing have been met with skepticism in the general public. Understanding patterns in behavior changes may be helpful to public health professionals and policymakers who develop health communication and revised guidelines in the efforts to contain the spread of the SARS-CoV-2 and future public health infections. Our study examined patterns in behavior changes. This study had two aims. First, using survey responses from 661 adults living in rural areas about changes they made to 20 different behaviors, we identified four classes of behavior changes: (1) non-social distancers (10.7%), (2) social distancers (54.0%), (3) social distancers making civic exceptions (24.0%), and (4) social distancers making religious exceptions (11.3%). Second, polytomous logistic regression was used to predict the probability of membership in those latent patterns of behavior change. Predictor variables included demographic variables  and variables theoretically predicted to covary with patterns of behavior change . This study provides insight into behavior changes during the outbreak of the SARS-CoV-2 virus that may be used by practitioners to understand variations in how people responded to the outbreak.


The ductus venosus (DV) carries oxygen-rich blood from the umbilical vein (UV) to the heart, bypassing the fetal liver. In 1:500 to 1:2500 pregnancies, the DV is either missing or it drains at an atypical site. The types of DV abnormalities are grouped according to the drainage site (intra- or extrahepatic) and whether they bypass the liver . The presence of a DV abnormality increases the risk of other fetal defects, especially cardiac and genetic abnormalities (3).In the image, color Doppler is used to demonstrate normal DV anatomy and five typical abnormalities:Figure Figure Figure Figure Figure Figure Figure


ESCs can be obtained from the inner cell mass of the blastocysts and give rise to all the embryonic three germ layers, however, the critical ethical predicament limits ESCs clinical applications. iPSCs possess the same differentiation capacity as ESCs but avoid ESCs usage-associated ethical dilemmas. Therefore, the generation of iPSCs Stem cells inhabit specialized microenvironments called “stem cell niches” that maintain a hypoxic and low level of reactive oxygen species (ROS) environment. The stem cell niche is essential for preserving stem cell stemness and self-renewal potency. ROS has been considered for a long time to be implicated in stress and various disorders and has been redefined as a vital signaling molecule with multifaceted functions in modulating stem cell biology and differentiation .2O2) and the superoxide anion radical (O2.-), are produced primarily by NADPH oxidases and controlled by growth hormones, cytokines, cytokines, mitochondrial electron transport chain. There are more than 40 enzymes involved in this process. H2O2 is implicated in a vast majority of redox-associated modulation of biological activities  reactions and form oxidative alteration on biological macromolecules, and ultimately activate key redox signaling and its related biological functions. Two key ROS signaling molecules hydrogen peroxide /protein kinase B (Akt) pathway. This finding is the main attribute in cyclic mechanical stress-mediated PDLSCs’ osteogenic differentiation.The cyclic mechanical stress was found to boost the ROS level and induce the expression of nuclear factor erythroid-2-related factor-2 (Nrf2) and its downstream molecules including heme oxygenase 1 (HO1) and NADPH dehydrogenase quinone 1 (NQO1), which ultimately promoted the osteogenic differentiation in human periodontal ligament stem cells (PDLSCs) . In thisSinenko et al. covers the recent advances in the physiological functions of the intracellular ROS as a signaling molecule and a secondary messenger of a wide range of cellular signaling in modulating the potency and differentiation of stem cells as well as the development of invertebrate Drosophila.A well-written review paper from Sheng et al. showed that a novel natural antioxidant compound, Caffeic acid (CA) efficiently delayed the aging events in the Drosophila gut, which is associated with the aberrant function of intestinal stem cells (ISCs) and the subsequent dysplasia. This beneficial antioxidant effect is attributed to the potency of CA to suppress oxidative stress-induced JNK signaling.A study by Drosophila as a proper genetic model for studying the mitochondrial electron transport chain and mitochondrial ROS-associated biological functions and the necessity of translating various pathophysiological aspects in Drosophila that are enigmatic in humans. While editing this Research Topicr, we hoped that the contributed research work would serve as an inspiration for scientists in the field to investigate further mechanisms and applications of ROS signaling in flies that could be translational for promoting ROS-mediated enhanced stem cell function and clinical applications.These studies underscored the importance of Wang et al. demonstrated the beneficial effects of the bone marrow mesenchymal stem cell-derived exosomes on the pathogenesis of osteoarthritis through targeting the competitive endogenous RNA (ceRNA) networks represented in LYRM4-AS1/GRPR/miR-6515-5p signaling pathway.Moreover,


Delusions are a key feature of schizophrenia psychopathology. From a phenomenological approach, Jaspers (1913) differentiates between “primary” or true schizophrenic delusions, defined as an unmediated phenomenon that cannot be understood in terms of prior psychological origin or motivation, and “secondary” delusions, understandable from the patient’s mood state or personality. Primary delusions have been considered the hallmark of reality distorsion dimension in schizophrenia, disregarding a possible affective patwhay to delusional belief.The present study was aimed at elucidating the psychopathological trajectories to delusion in schizophrenia through the investigation of both affective and schizotypal trait dispositions.Seventy-eight participants affected by schizophrenia were administered the Peters Delusional Inventory (PDI), the Positive and Negative Affective Scale (PANAS), the Experience of Shame Scale (ESS), the Referential Thinking Scale (REF), the Magical Ideation Scale (MIS) and the Perceptual Aberration Scale (PAS).The severity of delusional ideation (PDI) was positively related to both affective  and schizotypal traits . Moreover, referential thinking (REF) mediated the relationship between “magical ideation” (MIS) and delusions severity , whereas experience of shame (ESS) was a moderating factor in the between referential thinking and delusion severity .The study findings suggest that in schizophrenia patients, severity of delusions is underpinned by an intertwining of both affective and schizotypal pathways.No significant relationships.


The link between social connectedness and dementia risk and resilience has been examined using a diverse set of measures. Though different measures of connectedness reflect distinct social processes and underlying mechanisms , few studies have compared them. Using data from two social network studies of older adults (N=283), we compare associations between 29 measures of social connectedness and general cognitive function (MoCA), and non-verbal (Rey) and episodic memory (Craft). Measures of social participation  and social support were unassociated with cognitive outcomes, net of controls. Quality of friendships (p<.05), family relationships (p<.01), and marriage (p<.05) were sporadically associated. Measures indicating large, diverse, and expansive networks were strongly and consistently related to all cognitive outcomes . We discuss implications for theories of cognitive reserve.


Spouses often assume the role of informal caregivers for older adults living with mild cognitive impairment (MCI). These couples represent a population with low levels of physical activity, however, there is limited research regarding promotion of physical activity among these dyads. The purpose of this study was to evaluate the feasibility of a dyadic intervention, hypothesized to enhance physical activity via mutual support. We recruited three dyads (mean age: 66 [MCI] and 67 [spouse] years) from a local memory clinic. The dyads were asked to engage in physical activity together for 16 weeks. The weekly intervention consisted of 150 minutes of moderate-to-vigorous physical activity (MVPA) on their own and two lower body strength training sessions per week, one videoconferencing-supervised and one on their own. The adherence rate to the weekly MVPA and strength training was 88% and 83%, respectively. However, the percentage meeting the goal of 150 minutes/week of MVPA as measured using a Fitbit was 31% and 73% among those with MCI and spouses, respectively. There were no issues with the retention rate (100%) or safety; satisfaction scores were high . Exit interviews revealed three key themes: (1) value of the program , (2) difficulties , and (3) suggestions to improve the program (incorporating various types of strength training). Our dyadic intervention was feasible to support regular physical activity for older adults living with MCI and their spouses. Future work will incorporate participants’ feedback to optimize the intervention.


ASD with epileptic seizures (ES) and/or specific epileptic activity on EEG (EEG SEA) and repetitive movements and vocalizations (RMV) can be determined by different variants of genetic polymorphism or by different variants of gene expression, determined by different influences.To study the features of the clinical phenotype of ASD in preschool and school-age children with ES, EEG SEA and RMV.: The study group was divided 116 children aged 2-10 years with ASD into three subgroups: subgroup A - 23 children with a history of ES, subgroup B - 35 children with EEG SEA without ES, subgroup C - 19 children with ASD having EEG SEA, RMV . The control group consisted of 39 children with ASD non a history of ES and EEG SEA.: Children with ASD, complicated by severe and frequent ES are charactered by impaired social reciprocity and communication against the background of regression / stagnation of speech and motor skills development . Disoders of communication and repetitive behavior in ASD in children of different ages are represented by different monoqualitative syndrome (phenotypes). Movement stereotypes predominated in children with ASD without ES and without EEG SEA . In children with ASD and EEG SEA, motor stereotypes and repetitive behavior were equally common .: Disorders of social reciprocity, communication, repetitive behavior are diagnostically significant for ASD complicated by ES, ASD with EEG SEA.No significant relationships.


Emotion globalizing is an individual difference variable referring to the extent to which daily variations in an individual’s current emotions spillover into their evaluations of life satisfaction. The present research sought to: 1) extend the conception of emotion globalizing to stressor-related emotions, 2) examine age differences in these processes, and 3) differentiate associations with evaluations of life satisfaction and day satisfaction. To do so, we used daily diary data from two adult lifespan community samples . Multilevel models revealed older (compared to younger) adults exhibited less negative (but not positive) emotion globalizing and stressor-related emotion globalizing. No age differences were revealed in the association between stressor-related emotions and day satisfaction. These findings support and extend assumptions underlying the mechanisms of emotion globalizing and inform theories of emotional aging.


The International Health Regulations (IHR) 2005 are an international legal instrument adopted by World Health Organization General Assembly to strengthen global health security and empower the countries to prevent and respond to public health threats.This study was done within the Joint Action on Strengthened International Health Regulations and Preparedness in the EU (SHARP JA) with the aim to assess the strengths and weaknesses in preparedness and IHR implementation in order to develop and improve countries’ IHR capacities. Desk-based review and analysis of available data from the States Parties Annual Report tool (SPAR) from 2019 were done. Data (for 13 IHR capacities with 24 indicators) were analyzed for 15 countries participating in SHARP JA with gross national income (GNI) less than 90% of the EU average.The overall capacity for IHR implementation in low GNI countries is 69%, ranging from 33% in Bosnia and Herzegovina to 84% in Spain. The highest capacities are recognized in the area of Legislation and financing - 78%, IHR Coordination & NFP Functions - 77%, Food Safety - 76%, and Health service provision - 76%. The weak areas with the need for further improvement are recorded in the Points of entry (PoE) - 51%, Risk Communication - 52%, Chemical events - 60%, National health emergency framework - 65%, Surveillance - 66%, and Human Resources - 67%. The overall IHR capacity of low GNI countries is lower compared to the SHARP JA countries and the European average (76% and 73% respectively).The results have shown the strongest and the weakest points of the IHR implementation in low GNI countries. This indicates the need for capacity building and further development in identified areas .• The assessment of the strengths and weaknesses in preparedness and IHR implementation is the key prerequisite for identifying countries’ needs for their capacity enhancement.• Special attention should be given to the strengthening low GNI countries’ capacities.


There is emerging literature about older adults’ experience of loneliness during the COVID-19 pandemic in long term care (LTC) facilities due to isolation protocols. Additionally, staff challenges while providing care for older adults in LTC has also been highlighted. While the literature emphasizes negative pandemic experiences, a gap exists with understanding resilience during the pandemic in LTC settings. The aim of this qualitative descriptive study was to explore the experience of resilience in a Continuing Care Retirement Community (CCRC) among residents, their family members, and staff. We conducted 19 in-person interviews and 1 via Zoom in fall 2021 with 5 residents (65 and older), 5 family members, and 10 staff . A conventional content analysis was employed. While we did hear how the pandemic had a negative impact on everyone, the main themes of resilience identified were: 1) overcoming the pandemic together (sense of community); 2) experience and adaptation (over time being able to adapt to the disruption in their life); 3) staying safe (engaging in precautions and self-care strategies); and 4) positivity . Study findings can inform CCRC administrators on how to support residents, their family, and staff during future pandemics and other challenging times that may disrupt normal routines.