We will describe how neurosensory circuits relate information about nutrition, danger, and mates to initiate rapid changes health and aging, including evolutionarily conserved neural signaling pathways and molecules that extend organism lifespan. These findings provoke the notion that aging may be considered a complex behavior that is acutely malleable, susceptible to sensory influences, and strictly controlled by coordinated sets of neurons.


Women have a greater burden than men of white matter hyperintensities (WMH), a marker of cerebral small vessel disease (cSVD). Psychosocial factors including education, household income, neighborhood socioeconomic status (nSES), happiness, and depression may differ by gender and could explain women’s higher burden of WMH. In a cohort of older adults , we found that women had lower education, household income, nSES and were less happy and more depressed. Race stratified Spearman correlations showed women had greater whole brain WMH volume in white participants only . In partial Spearman correlations, education, happiness, and depression attenuated but did not fully explain the relationship when added individually or all together to the model for whites . Gendered psychosocial factors may partially explain sex differences in WMH; interventions targeting these factors may reduce cSVD burden, particularly in white women.


The Distinguished Faculty Award lecture will feature an address by2020 recipient Mary W. Carter, PhD. The Distinguished Faculty Award acknowledges individuals whose teaching stands out as exemplary, innovative, or influential-- or any combination thereof.


A new class of convolutional codes, called skew convolutional codes, that extends the class of classical fixed convolutional codes, is proposed. Skew convolutional codes can be represented as periodic time-varying convolutional codes but have a description as compact as fixed convolutional codes. Designs of generator and parity check matrices, encoders, and code trellises for skew convolutional codes and their duals are shown. For memoryless channels, one can apply Viterbi or BCJR decoding algorithms, or a dualized BCJR algorithm, to decode skew convolutional codes. Convolutional codes were introduced by Elias in 1955 , Massey non-binary convolutional codes. It is known that periodic time-varying convolutional codes improve the free distance and weight distribution over fixed convolutional codes; see, e.g., Mooser ,,Future w


Usually, prostate‐specific antigen (PSA) excretion from the NECAP tissue is scarce, making initial detection by PSA screening test complicated. In this case, Kobayashi The authors declare no conflict of interest.


Most family caregivers provide appropriate care and a supportive environment for their older relatives with dementia (PwD), yet the stress and strain associated with caregiving can trigger potentially harmful responses. Although much has been written about dealing with memory problems, researchers know less about how caregivers cope with difficult behaviors such as hallucinations, violent outbursts, or refusing food, medicine, or bathing. Interviews with 30 relatives providing care to community-dwelling PwD in rural Virginia revealed that caregivers typically used four behavior management strategies: reasoning with PwD; redirecting PwD’s attention; forceful actions, such as shouting at PwD; and withdrawing from interactions. Forceful management strategies and withdrawing from interactions were usually employed after reasoning and redirection failed to elicit desired behavior. Understanding whether caregivers’ expectations of PwD’s capacities are realistic, and why and when caregivers use various behavior management strategies, can help service providers develop appropriate educational interventions for frustrated caregivers.


The affiliation for the fifteenth author is incorrect. Stefano Cavalieri is not affiliated with #8 but with #9: Fondazione IRCCS Istituto nazionale dei tumori, Head and Neck Medical Oncology Unit, Milan, Italy.


Europe’s failure to manage a bold, common response would further increase divergence, strengthen anti-European forces and fuel populism.


Just as the classic BMC technique for LTL primarily aims at finding bugs, our approach also targets identifying counterexamples. BMC for LTL is reduced to SAT solving, because LTL describes a property via inspecting individual traces. Our BMC approach naturally reduces to QBF solving, as HyperLTL allows explicit and simultaneous quantification over multiple traces. We report on successful and efficient model checking, implemented in our tool called HyperQube, of a rich set of experiments on a variety of case studies, including security, concurrent data structures, path planning for robots, and mutation testing.This paper introduces a bounded model checking (BMC) algorithm for


We read with great interest the recent article by Morath et al. who conclude that plasma exchange (PE) improved inflammation, microcirculatory clot formation, and hypotension, thereby improving clinical outcomes . We woul


Embodied imagination is a learning theory that reverses the accepted Western“think first, then act” learning sequence though movement improvisation followedby reflection and reflective methods across verbal and nonverbal, includingembodied-kinesthetic, modalities. Healing the Cartesian divide might havepositive effects on world cultures and people across socioeconomic strata,especially urgent during the COVID-19 pandemic as multiple disruptions to dailylife have quickly increased uncertainty and stress, compromising health andwell-being, especially of traditionally marginalized excluded People of Color.Expanding the performative reflexive autoethnographic project through embodiedimagination broadens and deepens this global, transcultural, transdisciplinaryeffort through the human body, traditionally not considered human thinking’slocus. Benefits across global societies include greater self-care, the abilityto act effectively quickly in response to a world with exponentially increasingcomplexity, and awareness that creativity is a global communitarian humanbirthright, not a rarity relegated to exceptional people.


To the editor,Although there are no known risk factors for uretero-inguinal hernias we note that BMI could attribute and this patient had a BMI of 45, classified as morbid obesity , 2. TherThe Authors


In their discussion, Chow et al. state that for patients who cannot tolerate or absorb enteric oseltamivir due to gastric stasis, malabsorption, or other gastrointestinal processes, intravenous peramivir may be an alternative . They ad


Protecting and preventing older women from fatal and near fatal violence by current or former intimate partners are public health and international human rights concerns. Older women are most often killed (“femicide”), injured in the home by a spouse, partner, x-partner, or family member. Older women experience physical, psychological, sexual abuse, neglect, and financial exploitation. Wherein there is more research on risk factors, study of protections lags behind. Through three very different studies, risks and protections will be explored with national and international policy implications for each.


In the original publication of this article, we found an error under the section “Introduction”. The first sentence of the fourth paragraph appears incorrectly. The corrected sentence is given below.Isodon eriocalyx (Dunn.) Hara (family Lamiaceae) showing many pharmacological activities, such as inhibiting inflammatory response, regulating immune cell differentiation, inhibiting tumor cells proliferation, causing cell cycle arrest affecting angiogenesis and promoting cancer cells apoptosis.Eriocalyxin B, isolated and identified in 1982 [


Anshu Bharwaj is now affiliated with CSIR Institute of Microbial technology, Chandiagarh, India. Their updated email address is:


This chapter presents the different medical classifications and terminologies as ICD diagnosis codes, SNOMED CT, MeSH, UMLS, ATC etc.


Social motivations to engage in suicide in late life frequently include interpersonal problems and escape from perceived defeat. To describe decision making patterns that may contribute to the catastrophic decision to take one’s life, we used behavioral experiments and assessed cognitive abilities and personality traits. We found that neuroticism, low extraversion, and low conscientiousness characterize older adults who contemplate suicide and those with low-lethality suicide attempts. Employing a novel version of the Ultimatum Game, we measured empathy’s moderating response to social conflict. We found that older suicide attempters were less influenced by empathy scenarios, indicating that a failure to integrate others’ emotions into decisions may undermine social deterrents to suicide. To simulate social status loss, we used a newly developed, competitive task (rigged toward primarily losing outcomes) paired with performance ranking. We found that suicide attempters, especially those with narcissistic traits, engaged in more excessive compensatory behaviors than older non-attempters.


In the article titled “Utilization of Long-Acting Contraceptive Methods and Associated Factors among Female Health Care Providers in East Gojjam Zone, Northwest Ethiopia, in 2018” [The correct author order is shown below and also corrected in the author list:Manaye Meku Gella, Liknaw Bewket Zeleke, Hunegnaw Almaw Derseh, Addisu Alehegn Alemu, Eskeziaw Abebe Kassahun, and Kelemu Abebe Gelaw.


It has since been corrected.In the original research article, “Assessment of Cognitive-Motor Performance Costs, Task Prioritization, and Adaptation to Dishwashing Under Increased Demand in Older Women With Arthritis,” DOI:


An additional affiliation is missing for the fourth author. Ciro Indolfi is also affiliated with Mediterranea Cardiocentro, Naples, Italy.


The third author, Yogesh M. Chukewad, should be noted as contributing equally to this manuscript with the first two authors, Hari Krishna Hari Prasad and Ravi Sankar Vaddi.


Nearly 3 million older Americans with low incomes live in subsidized housing. This population has disproportionate rates of functional impairment, cognitive impairment, and nursing home admission. Staff members who work in subsidized housing may have unique insight into how to improve aging in place for this vulnerable population, but little is known about their perspectives. We conducted 12 focus groups with 69 staff members from 7 subsidized housing sites. Staff included property managers, service coordinators, maintenance workers, administrative assistants, and security guards. Transcripts were analyzed using qualitative thematic analysis. The majority of participants noted that they “wear multiple hats” and their roles are not limited to professional responsibilities. Instead, their role is to maximize residents’ quality of life. As a result, staff members often adopt personal roles akin to serving as residents’ “surrogate family” members. This relationship gives staff a unique window into residents’ lives which enables them to detect early warning signs among residents. For example, staff often observed changes in residents’ physical appearance and hygiene, mood, behavior, and function which could indicate physical illness, mental illness, or cognitive impairment. Staff reported having some resources to address these warning signs, such as involving families and connecting residents to community resources. However, they also highlighted unmet needs to address these issues, such as on-site clinical staff and affordable mental health services. Our findings suggest that building staff are a valuable and underutilized resource for identifying at-risk residents in subsidized housing and helping to deliver interventions to improve aging in place.


In the article titled “Prevalence and Predictors of Postpartum Depression: Northwest Ethiopia” , the ordEyerusalem Desta Zelalem, Mengstu Melkamu Asaye, Haymanot Alem Muche.


Hepatic Oncology (4)3, 69–73 (2017), was published with the authors’ names as Iezzi Roberto, Pompili Maurizio, Annicchiarico Eleonora Brigida, Garcovich Matteo, Siciliano Massimo, Gasbarrini Antonio & Manfredi Riccardo. This has now been corrected.The Case Report by authors Roberto Iezzi, Maurizio Pompili, Eleonora Brigida Annicchiarico, Matteo Garcovich, Massimo Siciliano, Antonio Gadbarrini & Riccardo Manfredi ‘‘Hug sign’: a new radiological sign of intraprocedural success after combined treatment for hepatocellular carcinoma’, which appeared in the July 2017 issue of Hepatic Oncology would like to sincerely apologize for any inconvenience or confusion this may have caused our readers.The authors and editors of


Javaudin et al.  recommenThird, after failure of thrombolysis, surgical embolectomy or catheter embolectomy should be considered in selected centers . Fourth,


Kiehl, MA. This article has been corrected.


The affiliation of the author Gino Seravalle was corrected to ‘IRCSS Istituto Auxologico Italiano, Milan, Italy’. The original article has been corrected.


Instead, we should have specifiedthat it was recently granted FDA Fast Track designation ;All reported results, statistics, and conclusions of the paperremain unchanged.


PLOS ONE Editors retract this article [The  article  because AN, MR, HA, SFM, SS, and SUR did not agree with the retraction. The other authors either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because LY, XG, LS, QZ, and BL either did not respond directly or could not be reached. LZ responded but expressed neither agreement nor disagreement with the editorial decision.Fig 5D appears to report material similar to that reported in , publish


PLOS ONE Editors retract this article [The  article  because  article  and Fig  article ,3, betwe article  and Fig  article  and Fig  article , and bet article  and Fig  article ,7. TheseAll authors either did not respond directly or could not be reached.


Due to a production error, an additional affiliation was incorrectly attributed to corresponding author Weiwei Ping.Their correct affiliation is:2Department of Public Health and Preventive Medicine, Changzhi Medical College, Changzhi, ChinaThe publisher apologizes for this mistake. The original article has been updated.


Implantable cardiac pacemakers have greatly evolved during the few past years, focusing on newer modalities of physiologic cardiac pacing. Indeed, non-physiologic pacing modalities, such as right ventricular (RV) pacing, have been shown to cause systolic dysfunction and heart failure (HF) over time. On the contrary, preserving myocardial synchrony during systole showed not only to improve cardiac contraction through myocardial reverse remodeling  but also


PLOS ONE Editors retract this article [The  article  because  article  and Fig  article , and Fig article  and Fig  article , between article  and Fig  article , and bet article  and Fig  article , 5. ThesAll authors either did not respond directly or could not be reached.


This article was republished on August 31, 2023, to include previously ommitted details concerning taxonomic registration. Please download this article again to view the correct version.


PLOS ONE Editors retract this article [The  article  because  article  and the  article . These cXW, YL, WX, LW, and XD either did not respond directly or could not be reached. LY responded but expressed neither agreement nor disagreement with the editorial decision.


PLOS ONE Editors retract this article [The  article  because SG, KNS, RMR, and MAK did not agree with the retraction. AMES, and MME either did not respond directly or could not be reached.


In the original version, onlyBruno Ehrler is listed as a corresponding author, but both Han Zuilhofand Bruno Ehrler are corresponding authors.


A young patient presented with migratory abdominal pain to the right iliac fossa. They regularly participated in Judo. Acute appendicitis was suspected, but at surgery, a ruptured lobulated tumour was found. Subsequent pathological examination demonstrated mesenteric lymphangioma with massive haemorrhagic necrosis and congestion.


PLOS ONE Editors retract this article [The  article  because MARR did not agree with the retraction. HGMDA, MN, YZ, AU, AS, and AQ either did not respond directly or could not be reached.


In this second session of our motivational interviewing workshop, we introduce motivational interviewing with its principles. Furthermore, we discuss the pyramid of change and Prochaska’s change model, address the differences between pre-contemplative versus change-resistant patients, and approach different techniques we can use throughout the clinical interview.None Declared


The last two authors, Justine I. Davies and Lisa R. Hirschhorn, should be noted as joint senior authors of this work.


It should be Puchner, not Pucher.After publication in Bio-protocol (


PLOS ONE Editors retract this article [The  article  because YZ responded but expressed neither agreement nor disagreement with the editorial decision. XS, CYan, BL, CYang, XN, XW, JZ, and YW either did not reply directly or could not be reached.


Due to a production error, each author’s first name and surname were erroneously interchanged. The corrected author list appears below.“Lorena Lorefice, Maristella Pitzalis, Federica Murgia, Giuseppe Fenu, Luigi Atzori, Eleonora Cocco“The original version of this article has been updated.


Following publication of the original article [1], in this article, the order that the authors appeared in the author list was incorrect. It should read as follow:Jiahao Shi, Di Chen, Zilin Wang, Shaolin Li and Shuying ZhangThe original article has been corrected.


Thus, we have replaced both pictures with our duplicated data. The corrected In the original publication , there w


PLOS ONE Editors retract this article [The  article  because FR, ZAN, and KSA did not agree with the retraction. FP, SAK, and NS either did not respond directly or could not be reached.


The two corresponding authors, Yossi Tsfadia and Yulia Einav, should be noted as contributing equally to this work.


Two trends are apparent in current early-stage drug discovery settings, firstly a revival of phenotypic screening strategies , and sec


Chemoinformatics, the brain child of Frank Brown , has nowNeural Network  providesIn this paper E.coli protein dataset  is used


Dear Editor,Thrombotic microangiopathy (TMA) occurs in IgA nephropathy, but is uncommon in the setting of IgA nephropathy. Recently an article published by El Karoui and colleagues, entitled “A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy” . They re


Dear Editor,We read with great interest the article entitled “The significance of case reports in biomedical publication” by Nayak. We congrIn conclusion, we recommend publication of all unusual/unique/rare presentations of diseases, especially by beginners.


The sixth author, Patrick Most, was incorrectly indicated as having contributed equally to the article with the first author, Anagha Sen. The sixth author should instead be indicated as being a co-senior author with the last author, Karsten Peppel.


Axonal and dendritic growth is a highly dynamic process, where neurites elongate, bifurcate and retract. Local calcium influx  or local


There is an error in paragraph two, sentence three of the Discussion. The sentence should read: "Importantly, our results do not single out a particular EMT inducing transcriptional repressor, although these are broadly expressed (Snail or Slug) in the cell lines."


Mechanical Testing Results. The mechanical testing analysis  resulted in no statistically significant differences for Young's modulus, compliance, ultimate circumferential stress, burst pressure, and suture retention strength; on the other hand, there was a significant loss in ultimate strain between native and decellularized vessels; moreover, residual stress after relaxation was increased for decellularized samples compared to native ones.


The authors' names were incorrectly listed as Tamburrelli Francesco Ciro, Scaramuzzo Laura, Genitiempo Maurizio, and Proietti Luca are corrected as stated above.


Recent experiments have observed a dynamical state characterized by so-called neural avalanches in different neural systems, such as networks of cultured neurons , the dev


Dear Editor,We read with great interest the article, "Hepatitis C virus and Lichen Planus: The real association" by Mahboobi et al.  because


Biologically motivated mathematical models, which describe the dynamics of the thrombocytopoietic, granulocytopoietic and erythropoietic systems in irradiated humans, are developed and thoroughly investigated –3. Thes


Barbara Fridrich was not included in the author byline. She should be listed as the seventh author and affiliated with Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München GmbH, Neuherberg, Germany. Her initials correctly appear in Author Contributions.


Dear Editor,Mesenchymal stem cells (MSCs) are characterized by ability to differentiate into several cell types and self-renewability. These stem cells have a limited capacity in cell lineage differentiation including osteogenic, adipogenic, chondrogenic, or myogenic lineage differentiations . RegardiBesides, it can be postulated that osteoblastic differentiation of MSCs may be influenced by mechanisms other than DNA methylation . Therefo


The fourth and fifth authors, Georges E. R. Grau and Valery Combes, should be noted as having contributed equally to this work.


Dear Editor,We read with great interest the article entitled "are hepatitis B virus and celiac disease linked?" by Leonardi, et al,  publishe


In neocortical epilepsy, pathological high-frequency oscillations (pHFOs) are consistently observed in EEG recordings seconds before seizure onset . While tNeurons contributing to pHFOs are known to synchronize their firing, presumably through the opening of axonal gap junctions . We arguUsing different types of neural mass models ,5, we de


The first two authors, Rolando Berlinguer-Palmini and Alessio Masi, should be indicated as having contributed equally to the article.


To The Editor:I read with interest the practice guidelines on nonalcoholic fatty liver disease (NAFLD),7In humans, excessive fructose intake can lead to increased hepatic lipid deposition, greater insulin resistance, and hypertriglyceridemia.


Gold clusters and nanoparticles have attracted continuous attention due to interesting and important electronic, catalytic and optical properties ,2. As th


The GeoArchive accession number for the microarray data, GSE42232, is incorrect. It should instead be GSE41355.


A central pattern generator (CPG) is a population of neurons producing rhythmic or repetitive behavior  without requiring rhythmic input to the population. Turtles are observed to produce several rhythmic motor patterns in response to stimuli, in particular rostral scratch, pocket scratch, caudal scratch, and forward swim (see Figure


The first two authors, Chi-Hwa Wu and Dabashis Sahoo, should be noted as contributing equally to this work.


The first author, Lei Wang, should also be noted as contributing equally to this work. Authors Lei Wang, Heng Guo and Xiao Yu share joint first authorship.


The prototypic autoimmune disease, systemic lupus erythematosus (SLE), is known to be associated with polyclonal B cell activation . A numbe


The following information was missing from the Funding section: "JTM, KPVO and ERGRA received funding from CAPES, CNPq and FAPEMIG."


The symbols representing modeled clams, modeled scallops, spirals, and isometric turritellid series were incorrect. Please view the correct Figure 5 legend here:


The fifth author, Bing Li, should be noted as a Corresponding Author, and her email address is icecreamlee@hotmail.com.


In the authors list the given names and surnames were inverted. The authors list should have been: Varun Pandey, Hagit Turm, Uriya Bekenstein, Sagiv Shifman and Sebastian Kadener.


The first two authors, Pascal Gosselin-Badaroudine and Dagmar I. Keller, should be noted as contributing equally to this work.


The last two authors, Freddy Haesebrouck and Bram Flahou, should be noted as sharing senior authorship.


Dear Editor,The correct estimation of renal function in patients with liver cirrhosis and chronic kidney disease (CKD) is difficult , 2. Dire


The following authors should have been designated as contributing equally to the article: Chao Lin, Xin-yu Zhao, and Lei Li.


Humans build muscle mass over the first two decades of life; begin to lose muscle mass and strength between the third and fourth decades, and the decline accelerates during the sixth decade ,2. SarcoIn mammalian cells, glucose is not freely permeable across the lipid bilayer, but enters by facilitated diffusion, a process in which specific integral membrane proteins passively transport glucose down a concentration gradient . Blood gMechanisms of hyperglycemic injury vary between cell types. Several of the well-known pathologic intracellular pathways directly associated with hyperglycemia include polyol pathway flux via aldose reductase activity , oxidatiWhile several studies have investigated the link between changes in skeletal muscle function and mass, skeletal muscle progenitor cells, muscle growth, development, repair, and metabolic activity in different models of diabetes mellitus –3,12–25,


Bayesian neural decoding models aim at estimating an extrinsic stimulus, such as speech, from a neural population. They have been used to study several physiological systems such as the motor or auditory systems . Such de


Behavior often requires remembering continuously structured information, e.g. positions in the visual field, over delay periods of up to seconds. How can a neural circuit reliably store this information using biophysical mechanisms that work on timescales of milliseconds? Recurrently connected networks with continuous attractors ,2 providIn neurons STF acts by dynamically regulating neurotransmitter release, mainly onto NMDA channels, however these simplified models neglect detailed synaptic integration mechanisms. It is thus unclear whether comparable stabilization can be achieved with biologically plausible synaptic dynamics, which limit the effects of STF, like activity dependent saturation of NMDA receptors  and condTo address this issue we combined two influential classes of models: spiking models of cortical networks with conductance based synapses and detailed dynamics of NMDA receptors , and mod


The seventh and eighth authors, Holger Moch and Giatgen A. Spinas, should be noted as contributing equally to this work.


She had no associated dyspnea, fever, or other clinical findings. An electrocardiogram and serum troponin level were unremarkable. Nonenhanced computed tomography (CT) of the chest  fat necrosis is a rare benign cause of sudden chest pain that can mimic more severe diseases such as myocardial infarction, pulmonary embolism, or pericarditis . PatientIt is important to recognize these characteristic CT findings of pericardial fat necrosis to avoid unnecessary exploratory thoracotomy for a benign lesion . James eThe differential diagnosis for a pericardial mass with fat attenuation includes primary fatty tumors , diaphragmatic hernias with abdominal fat occupying the cardiophrenic space, and mediastinitis.


The second affiliation for the tenth author is not indicated. Pier Luigi Meroni is also affiliated with: IRCCS Istituto Auxologico Italiano, Milan, Italy.


Cacospongia scalaris, has been achieved, mainly featuring Johnson–Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge


Our laboratory is addressing over the past decade inflammatory rheumatic diseases [With enormous speed novel data are emerging about regulating the expression of the genetically encoded information . This hidiseases , like rhdiseases ,4, noveldiseases . Also, mdiseases .None declared.


An 18 years old young patient with no history presented to the emergency department suffering from episodes of generalized seizures and atypical headache without fever, the onset of symptoms dated back to two months. The clinical examination was normal. CT scan showed an inter hemispheric fat density ovoid formation, measuring about 40x30cm along major axis, compressing the ventricular junctions on both sides with suspected partial agenesis of the corpus callosum , b, c, d


After publication of this study , we realAdriana Monea†, Gabriela Beresescu *†, Sorin Boeriu, Mezei Tibor, Sorin Popsor and Dragos Mihai Antonescu


Implementing and understanding effective early response to trauma requires multidisciplinary collaboration. While interprofessional collaboration is a fundamental competency for disaster and trauma mental health, journalists are often overlooked professional responders. As a result, few professions receive training to effectively cooperate with journalists. Yet, journalists play key roles in trauma responses as professional fact-finders, image collectors, and narrators to bear witness and serve as the public's eyes and ears .


In , we presGuillera-Arroita et al have presented in  a counteWe agree that we should not simply ignore imperfect detection. However, as we demonstrated in , standar


In the Results section, there are errors in both equations. Please view the complete, correct equations here:


The first two authors, Yi-Hao Wang and Rong Fu, should be noted as contributing equally to this work.


For instance, maternal exposures to fine particulate matter .


The following information is missing from the Funding section: YZ, WX, JY, QL and HY were supported by the TOTAL foundation (no. 2015–099).


Chromatin regulation in eukaryotes occurs through complex and interconnected mechanisms that ensure heterochromatin maintenance and compartmentalization of chromosome domains, genome stability, chromatin conformational changes before and after mitosis, gene silencing and transcriptional activation and chromatin remodeling at specific promoters. We refer to these events as a whole using the term “chromatin dynamics.” Chromatin dynamics involves a number of protein families including epigenetic enzymes, DNA repair factors, heterochromatin proteins, transcription factors and transcriptional regulators. Although lamins have been involved in almost all the processes that regulate chromatin dynamics, three m


Joanir P. Eler had been inadvertently misspelled, and Saulo Luz Silva was incorrectly listed as Paulo L. Silva.After publication of the original article , it cameThe updated author list of the original article appears correctly in this erratum.


With this erratum, we would like to clarify key differences between our current publication , and pri


A Total Diet Study (TDS) consists of selecting, collecting and analysing commonly consumed foods purchased at retail level, processing the food as for consumption, pooling the prepared food items into representative food groups, homogenizing the pooled samples and analysing them for harmful and/or beneficial chemical substances . TDSs ar


The first two authors, Michal Lederman and Shira Hagbi-Levi, should be noted as contributing equally to this work.


The sixth author, Nabarun Chakraborty, should be noted as contributing equally to this work.


Human brains possess sophisticated information processing capabilities, which rely on the interactions of billions of neurons. However, it is unclear how these capabilities arise from the collective spiking dynamics. A popular hypothesis is that neural networks assume a critical state ,2, becau


The ninth and tenth authors, Rosa Maria Borzì and Riccardo Meliconi, should be noted as contributing equally to this work.


On one hand, case reports are commented as ‘nonevidence-based anecdotes’. On the other hand, a number of independent studies warn against adverse health outcomes assigned to chromium picolinate (CrPic) dietary application ..2].High efficacy of a balanced diet, an individually optimised lifestyle and personalised treatment regiments can hardly be substituted by a limited number of single supplements to cover all the multifactorial risks such as the upward trends of population ageing, environmental risk factors, urbanisation, additive effects of diverse stress factors, incorrectly chosen lifestyle including unfavourable nutritional habits, increasing prevalence of obesity, low physical activity, etc . The pop


The third author, Lino Saez, should be designated as deceased. The publisher apologizes for this error.


We have identified an error in Additional file  Taxonomic assignments, total 16S rRNA gene sequences per taxa, and metadata.Click here for file


Second,diseases . These ndiseases  and are diseases . Eisenhudiseases  is basedThe shift toward proinflammatory immune responses through epigenetic programming after certain immunizations, which is stronger in females, might also explain increased female mortality rates observed after subsequent vaccinations. Diphtheria–tetanus–pertussis vaccination (DPT) is associated with increased mortality rates in girls, and this effect is stronger if BCG immunization was given previously , 8. A si


Dear Editor,APOC3 variants in coronary heart disease. Unfortunately, only a fraction of the previously published data have been considered and, using the authors’ inclusion criteria, over 10000 alleles are missing from the investigation  PMCID: PMC4723232


All sensory receptors adapt, i.e., they constantly adjust their sensitivity to external stimuli to match the current natural environment . Electro


Brucella species, the genomes of Brucella ceti, Brucella inopinata, Brucella netotomae, and Brucella suis biovar 4 were sequenced and analyzed.With the aim of developing quantitative PCR methods for the detection and differentiation of  Brucella are facultative intracellular bacteria, and many species have a high zoonotic potential. Brucella ceti was detected in whales, dolphins, seals, and sea lions , AZBH00000000 (Brucella ceti NCTC 12891T), AZBI00000000 (Brucella inopinata CAMP 6436T), and AZBJ00000000 (Brucella neotomae ATCC 23459T).The sequences belong to NCBI Bioproject PRJNA230241 and were deposited at DDBJ/EMBL/GenBank under the accession numbers


The first two authors, Katharine Eakin and Renana Baratz-Goldstein, should be noted as contributing equally to this work.


In the Author Contributions section, Avisek Das, Mert Gur and Mary Hongying Cheng are listed as having contributed equally to this work. Only Mert Gur and Mary Hongying Cheng contributed equally.


The second affiliation for the 9th author is not indicated. Maria Orietta Borghi is also affiliated with: IRCCS Istituto Auxologico Italiano, Milan, Italy.


The publisher apologizes for the error.The last author, Lei Wang, should be designated as co-corresponding author with Rumei Chen. Lei Wang’s email address is


Genome-wide association studies (GWAS) have recently identified many risk loci for complex human diseases. However, genetics can explain only a fraction of disease variation. Epigenetics refers to cellular mechanisms that affect gene expression without modifying DNA sequence. EpigeneBy integrating genetic, epigenetic, and transcriptomic data we developed genetic causality tests ,9 and a


PLOS ONE Editors retract this article [The  article  because AN, SUA, and AW did not agree with the retraction. MH, AFT, MN, and AS either did not respond directly or could not be reached.


Equation  should rr = 2R, should readConsequently, the two subsequent equations, where The angular velocity balance between Stokeslet vorticity and bottom-heaviness results in a lower bound for the rescaled torque


PLOS ONE Editors retract this article [The  article  because SAA did not agree with the retraction. CG, HS, MUF, MN, FG and MNA either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because MF, SUA, and SF did not agree with the retraction. MUH, MH, MJA, and MSA either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because EG, OMK, and MJA did not agree with the retraction. XW, MBudak, SAO, and MBrestic either did not respond directly or could not be reached.


Biology Open (2020) 9, bio049478 , including the potential fraudulent use of author details. We will update this notice as soon as possible.Concerns have been raised about


The Editor in Chief has retracted this article because it contains material that substantially overlaps with the following article .Xiaoping Chen, Xin Zhang and Sen He do not agree to this retraction. Ting Zhang, Shanshan Jia, Zhipeng Zhang, Runyu Ye, Xiangyu Yang have not responded to any correspondence from the editor/publisher about this retraction.


PLOS ONE Editors retract this article [The  article  because GB, SS, and SMP did not agree with the retraction. MB responded but expressed neither agreement nor disagreement with the editorial decision. MJA, SU, SA, and SAA either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because FRK responded but expressed neither agreement nor disagreement with the editorial decision. HK, MAB, KAK, HAG, SA, MJA and ZA either did not respond directly or could not be reached.


In the article entitled “Large papillary thyroid cancer bed recurrence causing overlying skin ulceration and bleeding”The correct author list should be as follows: Konstantinos A. Boulas, Maria Nathanailidou, Konstantinos Sitaridis, Isaac Filippidis, Ioannis Tsiariglis, Iliana Domi, Anestis Hatzigeorgiadis.The publisher apologizes for the error.


PLOS ONE Editors retract this article [The  article  because HA, MAW, AS, SAT, SI, MSE, and MC did not agree with the retraction. YL responded but expressed neither agreement nor disagreement with the editorial decision. MFS and JA either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because AAH, MA, and MSE either did not respond directly or could not be reached. MUA responded but expressed neither agreement nor disagreement with the editorial decision. AM, MNA, MT, and ZA did not agree with the retraction.


PLOS ONE Editors retract this article [The  article  because MI, MA, HA, HAEE, RZS, and TY did not agree with the retraction. AAH and DJD either did not respond directly or could not be reached.


To the editor,We appreciate the editorial comments on our manuscript , 2. UnfoThe authors.


PLOS ONE Editors retract this article [The  article  because NI, HY, MAES, and PA did not agree with the retraction. KT and NA responded but expressed neither agreement nor disagreement with the editorial decision. DIH either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because SNAK did not agree with retraction. EKT, KAK, MJA, SAF, DMBS, and ESME either did not reply directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because GMA, MAO, KBA, SMA, LNAH, and MAY did not agree with the retraction. MAM either did not respond directly or could not be reached.


In particular, we sharetheir concerns that a reference range (RR) should not be unnecessarily wide, leading toan avoidable low sensitivity of the RR. When a


PLOS ONE Editors retract this article [The  article , 2 becauMEAM agreed with retraction. KAK, HAG, ZA, and MAAEN either did not respond directly or could not be reached.


The PLOS ONE Editors retract this article  because SUK, FU, SF, ESD, SS, SD, and RD did not agree with the retraction. AAR responded but expressed neither agreement nor disagreement with the editorial decision. SM and FA either did not respond directly or could not be reached.


During their life cycle, plants experience a wide variety of environmental stresses that could compromise their growth and development or even threaten their survival. Plants have evolved sophisticated mechanisms to respond and, ultimately, adapt their morphology to such adverse environmental conditions. Drought, for example, is a complex abiotic stress causing worldwide agricultural yield losses every year . When plDuring the last decades, the vast majority of drought stress research aimed to increase the plant’s resilience to severe drought stress by boosting the protective mechanisms and the plant’s sensitivity to abscisic acid (ABA), a central phytohormone in drought resistance. While many such “over-protected” lines are resistant to severe drought, they show stunted growth and reduced yield under normal conditions or under moderate level of drought . Plant gPlant Physiology, Arabidopsis thaliana) plants treated with karrikin, a bioactive molecule derived from burning vegetation  decrease under drought .Conflict of interest statement. None declared.


Ambivalent ties are relationships that offer support but beget stress, which generally has a detrimental impact on health. Existing theory suggests that older adults gradually remove such ties over time; however, it is not uncommon for ambivalence to exist in older adults’ close relationships . Social network data was used from 286 older adults with about half having mild cognitive impairment. Roughly two-thirds of the sample reported at least one ambivalent tie, most commonly partners, children, and friends. Logistic regressions revealed distinct characteristics of these ties. Participants who reported at least one ambivalent tie  had social networks with structures known to confer cognitive benefits. Importantly, these effects dissipate with diminished cognitive status. Altogether, ambivalent ties may confer benefits when resources are available to manage such relationships. When resources are taxed, however, ambivalent ties may contribute to cascading health declines.


Pancreatic exocrine insufficiency (PEI) is a disorder causing symptoms such as maldigestion, malnutrition, diarrhoea, bloating, vitamin deficiency and weight loss . PEI is


PLOS ONE Editors retract this article [The  article  because TA, GG, AS, BK, and MAES did not agree with retraction. MNA responded but expressed neither agreement nor disagreement with the editorial decision.


Our presentation adopts a lens of intersecting inequalities based on gender and sexual orientation in exploring caregiving for a spouse or partner with dementia. How the division of labor shapes caregiving approaches is sometimes examined, but how this might differ by sexual orientation has not been explored. Previous research has often examined physical tasks and, to a lesser degree, emotion work. Here, we focus on cognitive labor : the mental labor involved in managing the household and social relationships, including anticipating needs, identifying ways to address these, making decisions, and monitoring outcomes. This theoretical backdrop informs our analysis of data garnered from in-depth interviews conducted among gay/lesbian and heterosexual older adults (N=57) who care for their spouses with dementia. However couples may have divided these cognitive steps previously, caregivers must perform them all alone, given care receivers’ cognitive losses. Our analyses reveal that caregivers find being responsible for everything exhausting, but this manifests differently based on gender and sexual orientation. Heterosexual women, for instance, found making all the decisions problematic, whereas heterosexual men reported difficulty in anticipating needs. For the most part, the challenging issues for gay and lesbian caregivers were more varied, as their previous division of labor had been negotiated differently, without a reliance on traditional gender roles. Finally, we uncover a novel domain for cognitive labor: being the “memory keeper.” Predominantly undertaken by women, this work involved maintaining important memories and markers of the care receiver’s (and couple’s) past.


To the Editor,Tucker et al. concluded current endoscope reprocessing methods do not eliminate human papillomavirus (HPV) and may allow it to be transmitted from carriers to other otolaryngology clinic patients. The authors suggested that orthophthalaldehyde (OPA) high‐level disinfectant (HLD) “may not be fully effective at removing HPV from endoscopes.”In similar studies, researchers generally describe the endoscopes and provide information about factors impacting reprocessing effectiveness, such as endoscope age and condition. This article does not reveal the number or type of endoscopes sampled, and the authors assumed endoscopes acquired viral DNA during the most recent procedure or processing step. If the 24 samples were taken from fewer than 24 endoscopes, it is possible certain endoscopes persistently harbored viral DNA. The researchers did not describe steps taken to ensure endoscopes were free of viral DNA before study initiation, and, therefore, it is impossible to know whether viral DNA was already present. Moreover, they did not say how aseptic conditions were maintained during sampling. This is concerning because even minor deviations from prescribed practicesInvestigations in other facilities utilizing OPA determined residual contamination was due to other causes. During an adenovirus outbreak among eight bronchoscopy patients, samples were taken from three bronchoscopes. Adenovirus DNA was detected in one, but there was no growth in viral cultures. Reprocessing was performed using an automated endoscope reprocessor (AER) with OPA by licensed personnel who had completed competency testing. The bronchoscopes underwent ethylene oxide sterilization before being sent to the manufacturer, which found critical defects requiring repair. Investigators deemed the cases pseudoinfections “resulting from nonviable adenovirus DNA remaining on bronchoscopes after cleaning and HLD,” potentially related to the use of damaged endoscopes and repeated bronchoscopy of an index patient with adenovirus pneumonia.Another outbreak investigation found bacterial pathogens in all samples taken from bronchoscopes that underwent manual HLD, but none in those reprocessed in an AER. Researchers sampled the sink, faucet, drainpipes, rinse water, reprocessing connecting tubes, and OPA. The outbreak strain was found in the rinse water, tubing, and sink drainpipes. No microorganisms were cultured from OPA. The contamination was terminated by replacing water filters, faucets, and plumbing.Although current standards recommend endoscopes be sterilized or reprocessed using AERs to ensure HLD parameters are consistently met,Studies have shown new endoscopes immersed in reprocessing sinks acquired protein, hemoglobin, and bacteria before clinical use could have introduced contaminants.There were no indications that other important aspects of standards were implemented in this clinic, such as performing leak tests and visual inspection, conducting tests to verify soil removal, and allowing only certified technicians to reprocess endoscopes.Cori L. Ofstead and Abigail G. Smart are employed by Ofstead & Associates Inc., an independent company that has received research grants, study materials, educational materials, or consulting contracts from companies involved in endoscope reprocessing or monitoring, including 3M Company, Advanced Sterilization Products, Ambu, Boston Scientific Corporation, Cleanis, Fortive, Healthmark Industries, Pentax, and Steris/Cantel/Medivators. Advanced Sterilization Products has supported our research related to orthophthalaldehyde, human papillomavirus, and reprocessing effectiveness. None of these companies reviewed the submitted work before submission.


PLOS ONE Editors retract this article [The  article  because MH did not agree with the retraction. MS, KJ, MASR, LW, MAES, and MNA either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because SaifU, TG, SA, MMW, ANS, and SamiU did not agree with the retraction. NMS and RSN responded but expressed neither agreement nor disagreement with the editorial decision.


A 44-year-old man who had undergone renal transplantation and on immunosuppressants (tacrolimus) presented with asymptomatic thick hyperpigmented lesions over the right knee for one month . He undePhialophora verrucosa, Fonsecaea pedrosoi, Fonsecaea compacta, and Cladophialophora carrioniiChromoblastomycosis, a chronic subcutaneous fungal infection, is caused by pigmented fungi such as


PLOS ONE Editors retract this article [The  article  because MSS either did not respond directly or could not be reached. ADA, SMZ, SS, NI and MNN did not agree with the retraction.


Clinical Case Reports, another author's name ‘Narjes Zarei Jalalabadi’ has to be included.In the article entitled “Plasma Cell Leukemia Presenting as Spontaneous Tumor Lysis Syndrome with Hypercalcemia”The correct list should be as follows: Mahan Shafie, Mahbod Issaiy, Mahdi Barkhori, Samaneh Parsa, Narjes Zarei Jalalabadi.The publisher apologizes for the error.


PLOS ONE Editors retract this article [The  article  because PA did not agree with the retraction. GM, NAA, MA, PK, and MAES either did not respond directly or could not be reached.


This qualitative study focused on understanding how to involve unpaid care partners (‘family members or friends’) of older adults who are participating in CAPABLE. Using field notes, focus groups, and key informant interviews, the study revealed considerations for involving care partners, including providing choices, defining roles, sharing information in a collaborative manner, and reinforcing knowledge and skills training. These findings can help guide organizations interested in involving care partners in their older adult programs.


PLOS ONE Editors retract this article [The  article  because HH, RA, ATKZ, and RZS did not agree with the retraction. MF and AHG either did not respond directly or could not be reached.


PLOS ONE Editors retract this article [The  article  because NAA and SA did not agree with the retraction. SS, MHS, SZ, SMA, MHA, and AA either did not respond directly or could not be reached.


The global SARS-CoV-2 pandemic with subsequently imposed restrictions and lockdowns also radically disrupted academic life. Many research projects involving recruitment of human subjects were abruptly put on hold, educational activities have moved into online trainings, scientific meetings have been transformed into virtual events. Social distancing does not restrict only everyday human contact but also limits direct exchange of clinical, educational, and research experiences, professional and academic networking, sharing ideas. Besides all the drawbacks, does the current situation also bring any advantages? Every challenge results in new opportunities. Although the online congresses will most likely never fully replace real-life experience, it was found that many work meetings can be held more efficiently via online communication. Saving time, cutting costs of travel and accommodation, plus other expenses, may help to allocate limited resources where needed. Similarly, while practical medical education and training cannot be substituted for remote broadcasting, many theoretical presentations can. More importantly, epidemic of COVID-19 is a unique opportunity for mental health research, to study individual and population consequences of the virus, its impact on psychiatric patients. It is still early to predict whether and when research, training, meetings, and other academic activities return back to “normal”, but appears that some changes are here to stay.No significant relationships.


Dear Editor,1.We have carefully reviewed an article that discusses antenatal depression. In this case, antenatal depression is significantly influenced by intimate partner violence . Meanwhile, of the eleven individual characteristic variables, six variables affect antenatal depression, namely civil status, family income, pregnancy planned, tobacco, alcohol and alcohol partners; while five variables  did not affect itThere are three questions related to this condition: 1) ‘Is it true that age, education level, occupation, mother tongue and parity do not affect antenatal depression?’; 2) ‘Could the five variables influence antenatal depression indirectly?’; and 3) ‘What statistical analysis can be used to analyze this indirect effect?’.In this study, the researchers used regression analysis, so that in the hypothesis it is assumed that all individual characteristic variables simultaneously affect antenatal depression directly. Referring to relevant references, these eleven variables should not all affect antenatal depression directly. There are several variables that influence antenatal depression indirectly through intermediary variables, for example: parity affects pregnancy planned, then pregnancy planned affects antenatal depression.2, we present an alternative framework for the relationship between related variables (4. Because the researchers use categorical data, one of the statistical programs that can be used is Smart-PLS3.Referring to a similar caseariables , which sFurthermore, we suggest that researchers perform further analysis using path-analysis, to obtain more complete information about the effect of these eleven variables on antenatal depression.


PLOS ONE Editors retract this article [The  article  because SA and SM responded but expressed neither agreement nor disagreement with the editorial decision. KSA, MS, MSE, MSH, and TA either did not respond directly or could not be reached.


Understanding the role of inflammation in developing respiratory illnesses such as COPD, asthma, and lung cancer, is critical. Natural cures are regaining favor as effective treatments for various ailments . A flavThe authors declare no conflict of interest.


This article , 2 has bPLOS Neglected Tropical Diseases Editors issue this Expression of Concern.PLOS will be investigating these concerns in accordance with COPE guidance and journal policies. Meanwhile, the


PLOS ONE Editors retract this article [The  article  because MH and SF did not agree with the retraction. SNAS, MN, KJ, and SA either did not respond directly or could not be reached.


Vertebral artery dissection (VAD) is a rare vascular cause of acute stroke. Although VAD may be classified as spontaneous or traumatic, it is increasingly recognized that trivial mechanical stress typically precipitates this potentially dangerous condition. Herein, we report a rare case of VAD and acute stroke following anterior cervical decompression and artificial disc replacement (ADR). To our knowledge, there have been no other cases of acute vertebrobasilar stroke caused by VAD following anterior cervical decompression and ADR. This case highlights that, although rare, acute vertebrobasilar stroke may occur after the anterior cervical approach.


PLOS ONE Editors retract this article [The  article  because SA responded but expressed neither agreement nor disagreement with the editorial decision. KAK, SAK, HAG, and AG either did not respond directly or could not be reached.


Reijnders et al. recently published an article concluding that, in their target trial emulation on critically ill patients with sepsis, they could not demonstrate an effect of treatment with low-dose erythromycin on mortality, secondary clinical outcomes, or host response biomarkers . However


This study examines variation in health service utilization and aging outcomes among older LGBTQ+ adults by access to an LGBTQ+ affirming health care provider. Primary survey data (n=1128) come from the Vanderbilt University Social Networks, Aging, and Policy Study, a panel study of older LGBTQ+ adults residing Alabama, Georgia, North Carolina, and Tennessee. Respondents with an LGBTQ+ affirming health care provider were more likely to seek preventative care, including routine checkups, colorectal screenings, flu shots, and HIV tests. Respondents with an LGBTQ+ affirming health care provider also reported higher control over their mental health and lower levels of cognitive decline. Overall, this study suggests that increasing access to LGBTQ+ affirming care could reduce health disparities among aging LGBTQ+ populations.


On angiography, a severely stenotic lesion of the distal left internal thoracic artery (LITA) was noted, which was a bypass graft to the left anterior descending (LAD) artery A, arrow.


Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis that classically affects the upper respiratory tract, lungs, and kidneys. The involvement of other organs occurs but is less frequent. Clinically overt cardiac involvement is rare. We present a rare case of thoracic pain caused by cardiac involvement in GPA, without any other symptoms. The diagnosis was made using an integral approach, with several complementary imaging modalities, including cardiac histology.


PLOS ONE Editors retract this article [The  article  because MU did not agree with the retraction. FR, II, AAN, JL, and MRK either did not respond directly or could not be reached.


DistincIn summary, significant species variance was revealed by our study,The authors declare no competing interests.


The publisher apologises that upon publication the authors names were incorrectly listed within the citation informationThe correct author information is:van Wijk R, van Selm L, Barbosa MC, van Brakel WH, Waltz M, Puchner KP .


Africa has been significantly affected by the ongoing coronavirus disease 2019 (COVID‐19) pandemic. It is noteworthy in this context that this is the continent with the poorest and most vulnerable populations to infectious diseases.Pneumonia is the leading global cause of mortality in children under 5 years old. However, this disease still occurs frequently in working‐age immunocompromised individuals and older adults (>70 y/o) with prior chronic conditions.Co‐infection with viral pneumonia is not rareIn addition to pneumonia, some African countries have faced other infectious diseases outbreaks.Another critical point is that Pneumococcal conjugate vaccine (PCV) and Haemophilus influenzae type b (HiB) vaccination were shown to significantly decrease the incidence and severity of pneumonia‐related mortality in children.Along with immunization, the inclusion of nutritional rehabilitation, zinc supplementation, exclusive breastfeeding, availability of drinking water and basic sanitation, and hygiene strategies will strengthen public health intervention for pneumonia prevention, especially amidst the COVID‐19 pandemic.Africa is plagued by a weak health care system associated with a significant immunocompromised population.Finally, it is also worthwhile to promote community engagement through cultural and religious leaders and enable risk communication in local languages to rapidly identify red flag symptoms of COVID‐19 pneumonia, especially in local communities. Furthermore, telemedicine may be applied to reach patients in rural settings, where healthcare may be scarce, improving infectious disease surveillance.We did not receive any funding for this project.The authors declare no conflicts of interest.Conceptualization: Olivier Uwishema.Data Curation: Olivier Uwishema, Helen Onyeaka, Baha Aldeen Abdalaziz Alshareif, Mohammed Eltahier Abdalla Omer, Alfredo Lorenzo Recio Sablay, Rabeet Tariq, Rayan Ibrahim Hamid Mohamed, Amirsaman Zahabioun, Mohamed Yousif Elamin Yousif, Elie Chalhoub, Marcos Roberto Tovani‐Palone.Formal Analysis: Olivier Uwishema, Helen Onyeaka, Baha Aldeen Abdalaziz Alshareif, Mohammed Eltahier Abdalla Omer, Alfredo Lorenzo Recio Sablay, Rabeet Tariq, Rayan Ibrahim Hamid Mohamed, Amirsaman Zahabioun, Mohamed Yousif Elamin Yousif, Elie Chalhoub, Marcos Roberto Tovani‐Palone.Methodology: Olivier Uwishema.Project Administration: Olivier Uwishema.Supervision: Marcos Roberto Tovani‐Palone.Writing – Original Draft Preparation: Olivier Uwishema, Helen Onyeaka, Baha Aldeen Abdalaziz Alshareif, Mohammed Eltahier Abdalla Omer, Alfredo Lorenzo Recio Sablay, Rabeet Tariq, Rayan Ibrahim Hamid Mohamed, Amirsaman Zahabioun, Mohamed Yousif Elamin Yousif, Elie Chalhoub, Marcos Roberto Tovani‐Palone.Writing – Review & Editing: Marcos Roberto Tovani‐Palone, Helen Onyeaka.All authors have read and approved the final version of the manuscript.The authors affirm that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned  have been explained.


Hortae werneckii, which occurs mainly in tropical and subtropical regionsTinea nigra is a rare, chronic, asymptomatic, and superficial keratophytosis caused by the dematiaceous fungus


This paper examines how volunteer roles are represented in Canadian long term care (LTC) policy in four Canadian jurisdictions, attending to how these regulated roles might impact resident quality of life. Overall, we found that policies define volunteer roles narrowly, which may limit residents’ quality of life. This happens through (1) omitting volunteers from most regulatory policy, (2) likening volunteers to supplementary staff rather than caregivers with unique roles, and (3) over-emphasizing residents’ safety, security and order. We offer insights into promising provincial policy directions for LTC volunteers, yet we caution against further regulating volunteers. Instead, we argue, addressing the cultural, social and structural changes required for volunteers to enhance LTC residents’ quality of life effectively.


GetSetUp started as a technology learning platform for older adults. During Covid-19 we realized that many adults not only wanted to learn technology but were eager for lifelong learning opportunities. Our specially designed technology platform offered a safe, welcoming space that fosters growth, learning, and community for older adults over 60,000 Michiganders over 60 joined in just 4 months. Case studies show how older adults can benefit from technology to feel empowered, reduce social isolation, and improve wellbeing through a job or volunteer opportunities and new friendships. Reports highlight this ongoing need for those with limited community, mobility issues, or those looking to diversify their communities. A trusted virtual community helps connect the physical world digitally to assure older adults understand processes like vaccine enrollment procedures. Virtual communities will not replace physical communities but offer research opportunities, reach more remote communities, and allow for collaboration with state and aging networks.


Injection targets including fat compartments and potential spaces will be outlined in key facial aesthetic subunits, including temple, cheek, lip, and jawline.This video will discuss high yield 3-dimensional surface topography landmarks for facial filler injections.


An additional affiliation is missing for the third author. Aml Mohamed Nada is also affiliated with Internal Medicine, Mansoura University, Mansoura, Egypt.


The impact of the COVID-19 pandemic has not been equal across economic sectors, age groups, education levels and employment status.


Despite an extensive literature on the stress process of caregiving, little attention has focused on how caregivers provide care (caregiving styles). To explore caregiving styles among 100 primary caregivers for persons living with dementia, we utilize k-modes machine learning analysis. This technique clusters caregiver’s use of behavioral  and cognitive  approaches into style profiles. Three styles were identified: Managers , Adapters , and Avoiders . Styles differ by demographic and care characteristics. Findings suggest that caregivers have variable approaches to care that are measurable, thus, targeting/tailoring interventions to caregiver style could be an effective approach.


Sense of purpose predicts slower cognitive decline, reduced risk for health issues, and greater longevity . However, work is limited regarding how we can help older adults maintain purposefulness in daily life. The current study explored positive daily social interactions as a route to daily purposefulness in older adults, using a measurement burst design. Older adults completed surveys for five-day bursts spread six months apart . Multilevel models demonstrated that on days when individuals reported more positive social interactions, they reported feeling more purposeful  when accounting for health, employment, and relationship status. Employment status moderated this association, as daily social interactions were more strongly associated with daily purpose for unemployed/retired individuals . Positive social interactions thus may help older adults maintain purposefulness, particularly after retirement.


The publisher apologises that upon publication of this article the authors names were swapped around, presenting the surname as their first.The authors correct names are Nancy Tamimi, Hanna Kienzler, Weeam Hammoudeh, Hala Khalawi, Mathias Regent and Rita GiacamanThe online version of this article has been updated.


Background: Properly administered, lumbar epidural analgesia provides adequate pain relief during labor anddelivery, and is considered to be a safe procedure with limited complications. The prevalence of infection afterlumbar epidural analgesia is negligible.Introduction:  Infection of the sacroiliac joint, although very close to the pucture area, has never been reported asa procedure complication.Case: In this report, we describe a patient who experienced bacterial sacroiliitis a few days after lumbar epiduralanalgesia for labor. No portal of entry was identified, and we evoked a new potential risk factor that has neverbeen proposed before, namely lumbar epidural analgesia.Conclusion:  Sacroiliitis must be considered as a rare but serious complication of lumbar epidural analgesia.


I agree with Ian Shrier  that, whAs Stephen Pauker  also poiI agree with Jonathan D. Wren  that it


The Essay by Lacasse and Leo  demonstrIn my clinical treatment of patients, consumer advertising is not only not helpful but often causes significant management problems. In addition, consumer advertising only focuses on expensive, patented medications and not on equally good generic alternatives. A good example is the consumer advertising of “the purple pill,” Nexium, while generic Prilosec, equally effective in almost all patients, is not advertised.Let's prohibit all consumer advertising of patented medications. It will save physicians much headache, and patients or their insurers a great deal of money.


Mucor species in a healthy woman is reported. Mucor vaginitis, which caused mild symptoms only, was refractory to conventional azole therapy and resistant to flucytosine. Cure was achieved with topicalamphotericin B.Although Zygomycetes cause life-threatening, opportunistic infections in immunocompromised hosts, the first caseof vaginitis caused by


As communicated in his letter, Abegaz represents Ajinomoto Corporate Services LLC. Ajinomoto, which holds 45% of the market share for worldwide aspartame production , is well


A 20-month-old boy, who underwent left nephrectomy, had a suprapubic catheter inserted that knotted within the bladder. This case report identifies possible causes for such occurrences and how best to manage them.


While wImproved diet, exercise, beta blockers, and angiotensin converting enzyme (ACE) inhibitors may all contribute protective effects to the heart against catecholamine surges and stress. While limited by sample size and potential selection bias, we did see a correlation between improved long-term outcomes and optimal medical therapy . This su


While we have not explored other population strata, such as by race, socioeconomic status, or environmental exposures, differences likely exist among these groups as well. The methods used by Putin et al.  are stat


Sir,Helicobacter pylori (Hp); Hp has been shown to have a role in causing both HCC (The very interesting paper by both HCC , and patboth HCC ; in addi


Wakefulness, rapid eye movement (REM) and non-REM sleep are not always mutually exclusive conditions, as commonly assumed. In some cases, the declaration of any state may be incomplete and states can fluctuate rapidly, resulting in peculiar behavioural syndromes such as narcolepsy, REM sleep behaviour disorder and status dissociatus. We briefly introduce this topic and discuss three suggestive clinical cases.


Women receiving induced abortions or postabortion care are at high risk of subsequent unintended pregnancy, and intervals of less than six months between abortion and subsequent pregnancy may be associated with adverse outcomes. This study highlights the prevalence and attributes of postabortion contraceptive acceptance from 2,456 health facilities in six major Indian states, among 292,508 women who received abortion care services from July 2011 through June 2014. Eighty‐one percent of the women accepted postabortion contraceptive methods: 53 percent short‐term, 11 percent intrauterine devices, and 16 percent sterilization. Postabortion contraceptive acceptance was highest among women who were aged 25 years and older, received first‐trimester services, received induced abortion, attended primary‐level health facilities, and had medical abortions. Doctors receiving post‐training support were more likely to offer contraceptives, but no association was observed between such support and acceptance of IUDs or sterilization. Comprehensive service‐delivery interventions, including ensuring availability of skilled providers and contraceptive commodities, offering clinical mentoring for providers, identifying and addressing provider bias, and improving provider counseling skills, can increase postabortion contraceptive acceptance and reduce unintended pregnancy.


We provide the monotonicity and convexity properties and sharp bounds for the generalized elliptic integrals  Hence, The functionin in  is stricLet formula , we have formula ,we get3relation , we takerding to , we haveLetThen we havefor allq. So we havep is obtained, which leads toBy direct calculation we obtainTaking


Dentistry Journal has set up this Special Issue on “Restorative and Esthetic Dentistry”. All studies about restorative and esthetic dentistry are welcome, including clinical case reports and studies on dental materials. Topics welcome in this issue include: veneer, tooth colored inlay/onlay, bleaching, full ceramic crown, oral rehabilitation of vertical dimension loss, direct and indirect composite resin restorations, dentin bonding agents, resin cement, zirconia implant, vital pulp therapy, Biodentine, Mineral trioxide aggregate (MTA), resin adhesive bridge, Maryland bridge, gingival esthetics, digital impression, laser cavity preparation, fiber post, and conservative restoration.Due to the development of dental materials and the esthetic requirements of patients, conservative restoration and esthetic dentistry is becoming more and more important. It is therefore timely to create a platform for all researchers and clinicians to share their experiences and studies in the field of “Restorative and Esthetic Dentistry”. To promote the development of this field and provide readers with updates in this area, veneertooth colored inlay/onlayceramic inlay/onlaycomposite resin inlay/onlaybleachingfull ceramic crownoral rehabilitation of vertical dimension losscomposite resin restorationfiber reinforced composite resindirect and indirect composite resin restorationsdentin bonding agentsdental adhesivesresin cementzirconia implantvital pulp therapyBiodentineMineral trioxide aggregate (MTA)dental weardentin hypersensitivityresin adhesive bridgeMaryland bridgegingival estheticsdigital impressionlaser cavity preparationfiber postconservative restoration


We thank all reviewers who, during 2017, helped to produce the Revista Brasileira deTerapia Intensiva with dedication and enthusiasm.


Adarsh Vennepurredy, however, the correct spelling is Adarsh Vennepureddy.When this article was initially published, the second author's name was misspelled as


The third author, Maria Andreia Nunes, should be noted as having also contributed equally to this work.


The traditional surgical training model relies on an apprentice style learning where junior doctors are gradually turned into independent surgeons through a process of observation, assisted operating, supervised operating and finally independent operating . All of Homayoun Zargar, MDDepartment of UrologyRoyal Melbourne Hospital300 Grattan St, ParkvilleVIC 3050, AustraliaEmail: Homi.zargar@gmail.com


Sir,Orthopedic surgeons commonly encounter cases of shoulder pain in their clinical practice, differential diagnosis of which includes, but is not limited to, septic arthritis. Usually perceived as ‘benign’, shoulder pain may be a harbinger of a serious underlying disorder including hematological malignancies. Jain et al. recently reported a case of chronic myeloid leukemia (CML) presenting as shoulder pain mimicking septic arthritis, and later diagnosed as myeloid sarcoma (MS) . MS repr


An affiliation for the first author is not indicated. Elena Lopez-Diez is also affiliated with #4, Universidade de Vigo, Vigo, Spain.


After prenatal diagnosis of bilateral fetal hydrothorax, ascites, and polyhydramnios, bilateral thoracoamniotic shunts were placed at 29 weeks gestation using an ultrasound-guided, minimally invasive technique. Anesthetic care was managed using intravenous sedation and local anesthesia infiltration. The anesthetic considerations for such procedures are discussed.


The first four authors, Lei Deng, Wei Li, Xingming Yu and Chao Gong, should be noted as contributing equally to this work.


Following publication of the original article , it was Helen Smith, Anayda Portela and Cicely MarstonThe full, correct author list can also be seen in this correction.


Upper gastrointestinal tract mucosa is prone to injury. Drugs may disturb gastric mucosaprotective mechanisms and cause damage. Injury by NSAIDs is a well described complication.Nifedipine, a widely used drug, was not described before as having a potential to damagegastrointestinal mucosa. We describe here, two patients, who developed esophageal andgastric mucosal damage, probably related to Nifedipine ingestion.


Experimental evidence supporting the postulated analogy between myelin basic protein and a previously described common tumour specific antigen is summarized under antigenic cross-reactivity, subcellular localization, molecular size, basicity and proteolipid nature. A third protein antigen, present in all tissues, also shows strong similarities in all these respects.


Annular pancreas can present in adult life, usually when inflammation of the pancreatic ring causesduodenal stenosis. Although peptic ulcer is often associated with annular pancreas, an association withgastric carcinoma has not been previously described. Here we report a patient with annular pancreas,chronic alcoholic pancreatitis and gastric carcinoma, who was successfully treated by radical proximalpancreatoduodenectomy.


Thirteen human peripheral lung tumours have been studied in both light and electron microscopy. They were classified as epidermoid carcinoma, mucus-secreting cell adenocarcinoma, and alveolar cell adenocarcinoma, the latter made up of granular pneumocytes. Alveolar cell cancer, as defined by ultrastructural features, could assume different gross histological patterns in light microscopy, and therefore electron microscopy is required for its identification.Since neither squamous nor mucous metaplasia was observed in any alveolar cell tumour, it is tentatively suggested that all peripheral lung tumours which lack these features may be derived from granular pneumocytes, irrespective of whether they appear to be adenocarcinomata or large cell carcinomata when examined by light microscopy.


We report on 17 isolates of Corynebacterium diphtheriae biotype mitis with related ribotypes from Switzerland, Germany, and France. Isolates came from skin and subcutaneous infections of injecting drug users, homeless persons, prisoners, and elderly orthopedic patients with joint prostheses or primary joint infections. Such isolates had only been observed in Switzerland.


The first two authors, Raghavan Madhavan and Zhuolin L. Gong, should be noted as contributing equally to this work.


The first three authors of this work, Dion Lepp, Bryan Roxas, and Valeria Parreira, should be considered as having contributed equally to this work.


Foodborne transmission of pathogenic and toxigenic microorganisms has been a recognized hazard for decades. Even half a century ago we knew about the dangers of botulism from underprocessed canned foods; staphylococcal poisoning from unrefrigerated cream-filled pastries, sliced ham, meat, and poultry salads; and salmonellosis from infected animal products. Despite new protective measures, changes in preservation techniques and failure to follow recognized procedures have created new dangers. Moreover, we now recognize new organisms that can cause foodborne illness--Listeria monocytogenes, Escherichia coli O157:H7, Campylobacter jejuni, Vibrio parahaemolyticus, Yersinia enterocolitica, and others. Controlling these organisms will require widespread education and possibly new regulatory initiatives.


Lymphocytes from patients with chronic lymphocytic leukaemia make large amounts of stable, rapidly labelled high molecular weight RNA, but ribosomal RNA methylation is normal. However, fewer ribosomes are available for protein synthesis than in normal lymphocytes.


Two large outbreaks of diarrheal illness associated with Cyclospora cayetanensis, a coccidian parasite, provided an opportunity to evaluate clinical syndromes associated with this enteric pathogen. Reiter syndrome, a triad of ocular inflammation, inflammatory oligoarthritis, and sterile urethritis, has been associated with enteric infections. We describe the first case of Reiter syndrome following protracted symptoms of Cyclospora infection.


There was an error in affiliation assignment for author Annibale Puca. This author should also be affiliated with: Istituto di Tecnologie Biomediche - Consiglio Nazionale delle Ricerche, Segrate, Italy.


Biliary tract disease is a relatively uncommon, heterogenous disease in pregnancy. Specifically,acute cholecystitis can be especially difficult to recognize in pregnancy. However, once diagnosed,the initial management plan should be conservative and include antibiotic therapy. Subsequentmanagement depends on the gestational age at diagnosis. Surgical therapy, when indicated,should not be delayed and a planned intervention during the second trimester appears to offer abetter outcome than surgery performed under emergent conditions.


Sir,With the advent of endoscopic neurosurgery, the endoscopes have now been applied to access intracranial tumours with favourable result. The literature revealed that this method has very few complications, including vision loss. We repor


She always brushed her hair backSternly, twisting one small knot about the crown.He did not like the plain, broad brow.“I hate that tightness,” he would mutter to himself.But sometimes he would stoop to kiss her foreheadAnd at midnight, hesitatingly, her lips,Surprised each time the way her arms would reach for him.When little Thomas had diphtheria at two,Her back was hourly bent above the crib,And one day as he stood beside herHe too bent, drawn helplessly, andKissed the tender whiteness of her neck,The unruly tendrils capturing his lips.With frost-cracked palm he strokedHer disciplined small head,And never thought to mutter any more.


I spy his head above the waves,big as a man’s fist,black eyes peering at me,until he dives into darker, deeper water.Yesterday I saw him a foot from my outstretched hand,already tilting his great domed shell away.Ribbons of green moss rippled behind him,growing along the ridge of his backand down his long reptilian tail.He swims in everything he knows,and what he knows is never forgotten.Wisely, he fears me as if I were the Plague,which I am, sick unto death,swimming to heal myself in his primeval sea.


The first two authors, Steven T. Suhr and Eun Ah Chang, should be noted as having contributed equally to this work.


However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in


Sir,It has been commonly thought that lumbar transverse process fractures as compared with body, pedicle and lamina fractures are minor injuries. A 40-yea1333153538


Sir,Neurosurgical patients including patients with severe head injury are at risk of developing respiratory complications, adversely affecting outcome and survival. Majority2


Analysis of 5 patients with gallbladder tuberculosiswho had open cholecystectomy and review ofliterature have shown that, although still rare it presentsas a part of systemic miliary tuberculosis,abdominal tuberculosis, isolated gallbladder tuberculosisand as acalculus cholecystitis in anergicpatients. There are no pathognomonic signs, thediagnosis depends on suspicion of tuberculosis, peroperativefindings and histological examination.


In Materials and Methods, under subheading Optimal trajectories, below Equation 14, the equation for Iij is incorrect. Please view the correct equation here:


The second affiliation for the sixth author is not indicated. Martín Prieto is also affiliated with: CIBEREHD, Instituto Carlos III, Madrid, Spain.


Schizophrenia is a debilitating psychiatric disorder that contributes to a large cascade of emotional, occupational, and cognitive impairments. Treatment involves combination of psychosocial rehabilitation and pharmacotherapy. In most cases, chronic antipsychotic therapy is required to treat symptoms, avoid relapse and attenuate episode recurrence


Crop breeding has been historically associated with genetic variation because genetic variants harboring traits with agronomic value can be artificially generated  and selected at the population  or individual level  through classical crop breeding methods. Crop genetic improvement, however, has become increasingly difficult, and crop genetic diversity has been declining at an alarming rate, threatening world food security and sustainable development , where the peloric epimutant bears actinomorphic flowers rather than normally zygomorphic flowers  can be transferred to epibreeding with the obvious differences in terms of epigenetic variant induction, production, and propagation that were discussed earlier. The result of classical crop breeding methods applied to standing, environmentally or artificially induced, epigenetic variation, might be stabilized when necessary by using vegetative propagation Fig. . SelectiHere we call for more studies on clonally propagated crops such as yam, cassava, sweet potato, taro, and potato (see Table S1 of McKey et al.,


Attaining adequate vancomycin levels among critically ill patients is an important issue. The early achievement of this target potentially avoids therapy failure, the emergence of multiresistant bacterial strains, and even possibly increased mortality , 2. The


Due to severe editor error, the following grammatical typos and inconsistencies were introduced during copy editing and have now been fixed in the udpated version of the article:Multiple instances of the word "the" introduced when grammatically incorrectEach mention of 'Klout Score' and 'Altmetric Score' should have had both words capitalized.The following errors were not corrected during copy editing, but have now been addressed in the updated version of the article:Abstract, Results section, first sentence: "were dedicated to the Twitter profiles" changed to 'had dedicated Twitter profiles."Introduction, first paragraph, first sentence: "are" changed to "is"Introduction, first paragraph, second sentence, "nearly" changed to "near"Introduction, third paragraph, second sentence: comma added after "Impact Factor"Materials and Methods, first paragraph, first sentence: "in the" changed to "of"Materials and Methods, first paragraph, fourth sentence: "twitter" has been capitalizedMaterials and Methods, first paragraph, fourth sentence: "were recorded." has been deletedMaterials and Methods, second paragraph, fourth sentence: comma added after "limited to"Materials and Methods, fifth paragraph, fifth sentence: commas deleted after "time" and "mentions"Discussion, first paragraph, third sentence: "SoMe most appropriate platform" changed to "SoMe platform most appropriate to analysis"Discussion, second paragraph, second sentence: "by" changed to "to"Discussion, third paragraph, first sentence: comma deleted after "time"Discussion, eighth paragraph, fourth sentence: "does not account for" changed to "is not accounted for"Discussion, ninth paragraph, first sentence: "provide" changed to "provides"Discussion, ninth paragraph, third sentence: "it's" changed to "it is"Discussion, tenth paragraph, second sentence: comma added after "platform"Conclusions, first paragraph, last sentence: comma added after "professionals"Cureus sincerely regrets these errors and has taken steps to ensure this will not happen again. Copies of the original, unaltered article are available upon request. Please contact for a copy of the unaltered article.


This presentation will discuss how we used CIAW 2017 to promote intergenerational community engagement by collaborating with our office of Continuing Education and AARP Connecticut to host “#DisruptAging – A Conversation Across Professions, Perspectives, and Generations.” Together we developed a half day program designed to build bridges among academic institutions, aging professionals, community collaborators, and consumers who are passionate about aging issues. We brought together a multi-generational audience of professors, students, professionals, and representatives of various community organizations to discuss ways to change the conversation around aging. This gave us an opportunity to highlight our gerontology programs and showcase our gerontology students, while students learned about aging-related careers, public policy initiatives, and organizations in Connecticut that support older adults and their families.


Money may not buy happiness, but can it buy a more positive outlook on aging? Past research examining the associations between indicators of socioeconomic status (SES) and subjective perceptions of aging have been mixed with some finding greater socio-economic resources predict more positive aging perceptions, whereas others find no connection. We examine objective  and subjective social status  and their connections to subjective age, attitudes towards aging, and awareness of age-related changes using hierarchical multiple regression analyzes. Participants  completed survey measures online. Results indicate minimal connection between income, education, and aging perceptions. However, perceiving oneself to be higher in social standing compared to one’s community was consistently related to more favorable perceptions of aging. Higher community standing may indicate favorable development, fewer stressors, or more resources compared to others, which could contribute to more positive perceptions of aging.


There is an error in affiliation 9 for author Angela Berardinelli. The correct affiliation is: IRCCS Mondino Foundation, Pavia, Italy.


We read the article of Hocaoğlu-Emre et al  entitledVitamin D deficiency screening should aim to identify people with low vitamin D levels who theoretically could benefit from vitamin D supplementation. Only after this theoretical screening program, we would expect improvement in particular health outcomes e.g improved bone mineral density, reduced risk of falls etc. Furthermore in any screening programme, the intervention and subsequent treatment should be harmless . HoweverIn conclusion, current evidence is not sufficient to suggest that screening for vitamin D deficiency in a healthy population produces health benefits, is necessary, safe or cost-effective.


The fourth author, Linghong Guo, should be noted as having also contributed equally to this work.