Datasets:
Card: simplify How this dataset is built section; link to source for full payloads
Browse files
README.md
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@@ -30,7 +30,7 @@ National Cancer Institute (NCI) Genomic Data Commons (GDC). One HuggingFace
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(HF) subset per TCGA project; one row per patient.
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- **Projects included:** `TCGA-CHOL`, `TCGA-DLBC`, `TCGA-LUAD`
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- **Generated:** 2026-05-05
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- **Source:** GDC `/cases` endpoint, open-access tier only.
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- **Schema:** derived from the [GDC Data Dictionary][gdc-dict]; the live
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dictionary the GDC was serving when the data was fetched is hashed into
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## How this dataset is built
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Three GDC REST endpoints feed every row
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### `POST /cases` — clinical entities
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One paginated POST per build, returning the nested case JSON for every
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patient in the requested projects.
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```json
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{
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"filters": {
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"op": "in",
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"content": {
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"field": "project.project_id",
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"value": [
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"TCGA-CHOL",
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"TCGA-DLBC",
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"TCGA-LUAD"
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]
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}
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},
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"fields": "case_id,submitter_id,primary_site,disease_type,index_date,consent_type,days_to_consent,days_to_lost_to_followup,lost_to_followup",
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"expand": "demographic,diagnoses,diagnoses.treatments,follow_ups,exposures,family_histories,project,samples,samples.portions,samples.portions.analytes,samples.portions.analytes.aliquots",
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"format": "JSON",
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"size": 200,
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"from": 0
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}
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```
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with `treatments[]` inside + `follow_ups[]` + `exposures[]` +
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`family_histories[]` + `samples[]` with `portions[].analytes[].aliquots[]`
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inside) is written to `<data-dir>/raw/<project>/cases.json` and feeds the
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`cases` config (and the consolidated patient row).
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### `POST /files` — molecular file discovery
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One POST per (project, modality) pair, listing every open-access file of
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that modality. Each modality is identified by a `data_type` plus a small
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set of clauses that lock the format / experimental strategy / workflow
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type so future GDC additions can't silently ship under the same
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`data_type`:
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- `data_type='Masked Somatic Mutation'` AND `data_format='MAF'` AND `data_category='Simple Nucleotide Variation'` AND `experimental_strategy='WXS'` AND `analysis.workflow_type='Aliquot Ensemble Somatic Variant Merging and Masking'`
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- `data_type='Gene Expression Quantification'` AND `data_format='TSV'` AND `data_category='Transcriptome Profiling'` AND `experimental_strategy='RNA-Seq'` AND `analysis.workflow_type='STAR - Counts'`
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Below is the full request shape for `Masked Somatic Mutation` against
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`TCGA-LUAD`; the build runs the same shape with the
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`Gene Expression Quantification` clauses too. Responses are written to
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`<data-dir>/raw/<project>/<modality>/manifest.json` and feed the `files`
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config.
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```json
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{
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"filters": {
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"op": "and",
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"content": [
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{
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"op": "=",
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"content": {
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"field": "cases.project.project_id",
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"value": "TCGA-LUAD"
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}
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},
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{
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"op": "=",
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"content": {
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"field": "access",
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"value": "open"
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}
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},
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{
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"op": "=",
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"content": {
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"field": "data_type",
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"value": "Masked Somatic Mutation"
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}
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},
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{
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"op": "=",
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"content": {
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"field": "data_format",
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"value": "MAF"
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}
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},
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{
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"op": "=",
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"content": {
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"field": "data_category",
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"value": "Simple Nucleotide Variation"
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}
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},
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{
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"op": "=",
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"content": {
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"field": "experimental_strategy",
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"value": "WXS"
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}
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},
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{
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"op": "=",
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"content": {
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"field": "analysis.workflow_type",
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"value": "Aliquot Ensemble Somatic Variant Merging and Masking"
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}
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}
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]
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},
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"fields": "file_id,file_name,file_size,md5sum,access,data_category,data_type,data_format,experimental_strategy,analysis.workflow_type,cases.case_id,cases.submitter_id,cases.samples.portions.analytes.aliquots.aliquot_id",
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"format": "JSON",
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"size": 500,
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"from": 0
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}
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```
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### `POST /
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```
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are parsed gene-row-by-gene-row into the
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`gene_expression_quantification` config. (See `tcga2hf.gdc.bulk_download`
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for the batching + retry logic.)
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### Other GDC calls captured for provenance
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- `GET /status` — once at the top of every build; `data_release` /
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`tag` / `commit` are saved in each project's `gdc_status.json`.
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- `GET /v0/submission/_dictionary/_all` — once at the top of every build;
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written to `<data-dir>/raw/gdc_dictionary.<major>.<minor>.json` and its
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SHA-256 is recorded in `gdc_status.json`. The static schema in
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`tcga2hf.schema` is regenerated from this dictionary; see the package
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`scripts/regenerate_clinical_fields.py`.
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## Loading
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(HF) subset per TCGA project; one row per patient.
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- **Projects included:** `TCGA-CHOL`, `TCGA-DLBC`, `TCGA-LUAD`
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+
- **Generated:** 2026-05-05 15:19:38 UTC
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- **Source:** GDC `/cases` endpoint, open-access tier only.
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- **Schema:** derived from the [GDC Data Dictionary][gdc-dict]; the live
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dictionary the GDC was serving when the data was fetched is hashed into
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## How this dataset is built
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Three GDC REST endpoints feed every row, with filters and field lists
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constructed in [`src/tcga2hf/clinical.py`][src-clinical] (the `cases`
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table) and [`src/tcga2hf/genomic.py`][src-genomic] (molecular and
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provenance tables) of the [`tcga2hf` repo][repo].
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**Projects fetched in this build:** `TCGA-CHOL`, `TCGA-DLBC`, `TCGA-LUAD`.
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### `POST /cases` → `cases` table
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Filter: `project.project_id IN [<projects above>]`. The request `expand`s
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the full nested `case` structure (demographic + diagnoses → treatments +
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follow_ups + exposures + family_histories + samples → portions →
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analytes → aliquots), and the response is captured verbatim into
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`<data-dir>/raw/<project>/cases.json` per project. See
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`tcga2hf.clinical.TOP_LEVEL_FIELDS` and `tcga2hf.clinical.EXPANSIONS`
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for the exact field/expand lists.
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### `POST /files` → `masked_somatic_mutation`, `gene_expression_quantification`, `files` tables
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One POST per (project, modality). All requests share
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`cases.project.project_id = <project>` AND `access = open`. The
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remaining clauses lock the format / experimental strategy / workflow
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type so future GDC additions can't silently ship a different pipeline
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under the same `data_type`:
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| Table | data_type | data_format | data_category | experimental_strategy | analysis.workflow_type |
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|---|---|---|---|---|---|
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| `masked_somatic_mutation` | `Masked Somatic Mutation` | `MAF` | `Simple Nucleotide Variation` | `WXS` | `Aliquot Ensemble Somatic Variant Merging and Masking` |
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| `gene_expression_quantification` | `Gene Expression Quantification` | `TSV` | `Transcriptome Profiling` | `RNA-Seq` | `STAR - Counts` |
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The combined `/files` responses (one per modality per project) feed the
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`files` table. See `tcga2hf.genomic.MODALITY_FILTERS` and
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`tcga2hf.genomic.FILE_FIELDS` for the full request payload.
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### `POST /data` → file bytes
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UUIDs returned by `/files` are batched (≤50 per request) into `POST
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/data`; the response is a tar.gz of those files. Mutations files are
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parsed row-by-row into the `masked_somatic_mutation` config; expression
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files are parsed gene-row-by-gene-row into the
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`gene_expression_quantification` config. See
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`tcga2hf.gdc.bulk_download` for the batching and retry logic.
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### Provenance pinned per build
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- `GET /status` → `data_release` / `tag` / `commit` saved in each
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project's `gdc_status.json`.
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- `GET /v0/submission/_dictionary/_all` → schema dictionary snapshot
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saved alongside the raw data; its SHA-256 is recorded in
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`gdc_status.json`.
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[src-clinical]: https://github.com/galtay/tcga2hf/blob/main/src/tcga2hf/clinical.py
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[src-genomic]: https://github.com/galtay/tcga2hf/blob/main/src/tcga2hf/genomic.py
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## Loading
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