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README.md

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+---
+license: mit
+task_categories:
+  - feature-extraction
+language:
+  - en
+tags:
+  - biology
+  - proteins
+  - thermophiles
+  - protein-engineering
+  - alphafold
+size_categories:
+  - n<1K
+---
+
+# APED: African Protein Engineering Dataset
+
+A curated dataset of protein structures from African thermophilic organisms, designed for machine learning applications in protein engineering.
+
+## Dataset Description
+
+This dataset contains structural and sequence features extracted from AlphaFold-predicted structures of proteins from thermophilic organisms found in African extreme environments (hot springs, volcanic regions).
+
+### Features (19 total)
+
+| Feature | Description |
+|---------|-------------|
+| `uniprot_id` | UniProt accession |
+| `organism` | Source organism |
+| `sequence` | Amino acid sequence |
+| `sequence_length` | Number of residues |
+| `mean_plddt` | Mean AlphaFold confidence |
+| `helix_fraction` | α-helix content |
+| `sheet_fraction` | β-sheet content |
+| `coil_fraction` | Coil content |
+| `hydrophobicity` | Mean hydrophobicity |
+| `charge` | Net charge at pH 7 |
+| `molecular_weight` | Molecular weight (Da) |
+| `isoelectric_point` | Predicted pI |
+| `instability_index` | Sequence instability |
+| `aromaticity` | Aromatic residue fraction |
+| And more... | |
+
+### Statistics
+
+- **500 proteins** with full features
+- **981 AlphaFold structures** downloaded
+- **3 novel designs** with pLDDT > 90%
+
+## Novel Protein Designs
+
+Included are 3 computationally designed proteins generated using:
+1. **RFdiffusion** - backbone generation
+2. **ProteinMPNN** - sequence design  
+3. **AlphaFold** - structure validation
+
+Best design: **91.9% pLDDT, 0.74Å RMSD**
+
+## Usage
+
+```python
+from datasets import load_dataset
+
+dataset = load_dataset("electricsheepafrica/APED-African-Protein-Engineering-Dataset")
+```
+
+## Citation
+
+If you use this dataset, please cite:
+```
+@dataset{aped2024,
+  title={APED: African Protein Engineering Dataset},
+  author={Electric Sheep Africa},
+  year={2024},
+  publisher={HuggingFace}
+}
+```
+
+## License
+
+MIT License