class:All alpha proteins
fold:Multiheme cytochromes
superfamily:Multiheme cytochromes
family:Cytochrome c3-like
protein:Nine-heme cytochrome c


class:All alpha proteins
fold:EF Hand-like
superfamily:EF-hand
family:S100 proteins
protein:Calcyclin (S100)


protein:Aldehyde reductase (dehydrogenase), ALDH


family:Group II chaperonin (CCT, TRIC), ATPase domain


protein:Protein disulfide isomerase, PDI


class:Alpha and beta proteins (a/b)
fold:Cytidine deaminase-like
superfamily:Cytidine deaminase-like
family:Cytidine deaminase
protein:Two-domain cytidine deaminase


class:Alpha and beta proteins (a/b)
fold:Thiolase-like
superfamily:Thiolase-like
family:Thiolase-related
protein:Thiolase


superfamily:Nitrile hydratase alpha chain


superfamily:FAD-linked oxidases, C-terminal domain


family:Dimeric isocitrate & isopropylmalate dehydrogenases


class:All alpha proteins
fold:Citrate synthase
superfamily:Citrate synthase
family:Citrate synthase
protein:Citrate synthase


protein:DNA-repair enzyme exonuclease III


class:All alpha proteins
fold:Annexin
superfamily:Annexin
family:Annexin
protein:Annexin V


protein:First Zn-domain of early E2A DNA-binding protein, ADDBP


protein:Fimbrin (Plastin), actin-crosslinking domain


fold:Aldehyde ferredoxin oxidoreductase, N-terminal domain

superfamily:Aldehyde ferredoxin oxidoreductase, N-terminal domain


family:Hedgehog C-terminal (Hog) autoprocessing domain


superfamily:Amine oxidase N-terminal region

protein:Copper amine oxidase, domains 1 and 2


family:Group I mobile intron endonuclease


protein:Histidine kinase CheA, C-terminal domain


family:Domains B1 and B5 of PheRS-beta, PheT

protein:Domains B1 and B5 of PheRS-beta, PheT


family:DNA polymerase processivity factor


class:Multi-domain proteins (alpha and beta)


class:All alpha proteins
fold:Serum albumin-like
superfamily:Serum albumin-like
family:Serum albumin-like
protein:Serum albumin


protein:Extracellular region of human tissue factor


superfamily:Bactericidal permeability-increasing protein, BPI

protein:Bactericidal permeability-increasing protein, BPI


protein:Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains


superfamily:Glutathione synthetase ATP-binding domain-like

protein:Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains


class:All beta proteins
fold:beta-Prism I
superfamily:Mannose-binding lectins
family:Mannose-binding lectins
protein:Heltuba lectin


fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes

superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes


family:TATA-box binding protein (TBP), C-terminal domain

protein:TATA-box binding protein (TBP), C-terminal domain


fold:Carbamoyl phosphate synthetase, large subunit connection domain

superfamily:Carbamoyl phosphate synthetase, large subunit connection domain

protein:Carbamoyl phosphate synthetase, large subunit connection domain


superfamily:delta-Endotoxin (insectocide), middle domain

protein:delta-Endotoxin (insectocide), middle domain


fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)


protein:Gelatinase A (MMP-2) type II modules


fold:Monooxygenase (hydroxylase) regulatory protein

superfamily:Monooxygenase (hydroxylase) regulatory protein

protein:Soluble methane monooxygenase regulatory protein B


class:All alpha proteins
fold:EF Hand-like
superfamily:Cloroperoxidase
family:Cloroperoxidase
protein:Cloroperoxidase


class:Multi-domain proteins (alpha and beta)

fold:Prokaryotic type I DNA topoisomerase

superfamily:Prokaryotic type I DNA topoisomerase

protein:DNA topoisomerase I, 67K N-terminal domain


superfamily:Cna protein B-type domain (Pfam 05738)

protein:B repeat unit of collagen binding surface protein (cna)


class:Small proteins
fold:TNF receptor-like
superfamily:TNF receptor-like
family:TNF receptor-like
protein:Death receptor-5 (dr5) fragment


family:AraC type transcriptional activator

protein:Rob transcription factor, N-terminal domain


class:Alpha and beta proteins (a+b)
fold:mRNA triphosphatase CET1
superfamily:mRNA triphosphatase CET1
family:mRNA triphosphatase CET1
protein:mRNA triphosphatase CET1


fold:Knottins (small inhibitors, toxins, lectins)


class:All beta proteins
fold:beta-Trefoil
superfamily:Actin-crosslinking proteins
family:Fascin
protein:Fascin


family:NAD+-dependent DNA ligase, domain 3

protein:NAD+-dependent DNA ligase, domain 3


protein:Fetuin-binding protein Scafet precursor


fold:Formate dehydrogenase/DMSO reductase, domains 1-3

superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3

protein:Dimethylsulfoxide reductase (DMSO reductase)


class:Alpha and beta proteins (a/b)
fold:Chelatase-like
superfamily:Chelatase
family:Ferrochelatase
protein:Ferrochelatase


fold:Rhodanese/Cell cycle control phosphatase

superfamily:Rhodanese/Cell cycle control phosphatase


superfamily:Ribosomal protein S5 domain 2-like

protein:Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4


superfamily:Ribonuclease PH domain 2-like

protein:Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5


class:All alpha proteins
fold:Cyclin-like
superfamily:Cyclin-like
family:Cyclin
protein:Cyclin A


class:All alpha proteins
fold:Cytochrome c
superfamily:Cytochrome c
family:Di-heme cytochrome c peroxidase
protein:Di-heme cytochrome c peroxidase


superfamily:Helical backbone metal receptor

family:Periplasmic ferric siderophore binding protein FhuD

protein:Periplasmic ferric siderophore binding protein FhuD


fold:Elongation factor Ts (EF-Ts), dimerisation domain

superfamily:Elongation factor Ts (EF-Ts), dimerisation domain

protein:Elongation factor Ts (EF-Ts), dimerisation domain


superfamily:D-aminopeptidase, middle and C-terminal domains

protein:D-aminopeptidase, middle and C-terminal domains


fold:Probable bacterial effector-binding domain

superfamily:Probable bacterial effector-binding domain

family:Multidrug-binding domain of transcription activator BmrR

protein:Multidrug-binding domain of transcription activator BmrR


class:Alpha and beta proteins (a+b)
fold:Phospholipase D/nuclease
superfamily:Phospholipase D/nuclease
family:Phospholipase D
protein:Phospholipase D


class:Alpha and beta proteins (a+b)
fold:Pepsin inhibitor-3
superfamily:Pepsin inhibitor-3
family:Pepsin inhibitor-3
protein:Pepsin inhibitor-3


family:Glutamine synthetase catalytic domain

protein:Glutamine synthetase, C-terminal domain


class:All beta proteins
fold:gamma-Crystallin-like
superfamily:gamma-Crystallin-like
family:Killer toxin-like protein SKLP
protein:Killer toxin-like protein SKLP


fold:Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

superfamily:Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

family:Glyoxalase I (lactoylglutathione lyase)

protein:Glyoxalase I (lactoylglutathione lyase)


family:FAD/NAD-linked reductases, N-terminal and central domains


class:All beta proteins
fold:beta-Trefoil
superfamily:Cytokine
family:Fibroblast growth factors (FGF)
protein:Basic FGF (FGF2)


class:All beta proteins
fold:Methuselah ectodomain
superfamily:Methuselah ectodomain
family:Methuselah ectodomain
protein:Methuselah ectodomain


protein:Xanthine dehydrogenase chain B, C-terminal domain


superfamily:Winged helix DNA-binding domain

family:Restriction endonuclease FokI, N-terminal (recognition) domain

protein:Restriction endonuclease FokI, N-terminal (recognition) domain


class:Membrane and cell surface proteins and peptides

protein:Glycerol uptake facilitator protein GlpF


fold:Open three-helical up-and-down bundle

superfamily:Methane monooxygenase hydrolase, gamma subunit

protein:Methane monooxygenase hydrolase, gamma subunit


class:Alpha and beta proteins (a+b)
fold:Chorismate lyase
superfamily:Chorismate lyase
family:Chorismate lyase
protein:Chorismate lyase


class:All beta proteins
fold:Immunoglobulin-like beta-sandwich
superfamily:E set domains
family:Arrestin
protein:Arrestin


family:Ribosome anti-association factor eIF6 (aIF6)

protein:Ribosome anti-association factor eIF6 (aIF6)


superfamily:Transglutaminase, two C-terminal domains

protein:Transglutaminase, two C-terminal domains


class:All beta proteins
fold:SH3-like barrel
superfamily:Chromo domain-like
family:Chromo domain
protein:Heterochromatin protein 1, HP1


superfamily:PFL-like glycyl radical enzymes


protein:Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF


class:All alpha proteins
fold:Four-helical up-and-down bundle
superfamily:alpha-catenin/vinculin
family:alpha-catenin/vinculin
protein:alpha-catenin


protein:CBP80, 80KDa nuclear cap-binding protein


family:BiMOP, duplicated molybdate-binding domain

protein:Cytoplasmic molybdate-binding protein ModG


superfamily:AFP III-like domain (Pfam 01354)

protein:Type III antifreeze protein, AFP III


superfamily:Prokaryotic type KH domain (KH-domain type II)

protein:Transcription factor NusA, C-terminal domains


protein:Mitochondrial processing peptidase (MPP) alpha chain


fold:Leukotriene A4 hydrolase N-terminal domain

superfamily:Leukotriene A4 hydrolase N-terminal domain

protein:Leukotriene A4 hydrolase N-terminal domain


fold:Periplasmic binding protein-like II

superfamily:Periplasmic binding protein-like II


protein:Anthranilate synthase aminodeoxyisochorismate synthase/lyase subunit, TrpE


fold:Common fold of diphtheria toxin/transcription factors/cytochrome f

superfamily:Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor

protein:Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor


protein:4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpcE


fold:Reductase/isomerase/elongation factor common domain


class:Alpha and beta proteins (a+b)
fold:Ferredoxin-like
superfamily:YajQ-like
family:YajQ-like
protein:Hypothetical protein HI1034


superfamily:Acyl-CoA dehydrogenase C-terminal domain-like

family:Peroxisomal acyl-CoA oxidase-II, domains 3 and 4

protein:Peroxisomal acyl-CoA oxidase-II, domains 3 and 4


protein:Xylan binding domain, CBM13 (Endo-1,4-beta-xylanase C-terminal domain)


class:All beta proteins
fold:Immunoglobulin-like beta-sandwich
superfamily:Immunoglobulin
family:I set domains
protein:Type-1 interleukin-1 receptor


class:All alpha proteins
fold:Heme-dependent peroxidases
superfamily:Heme-dependent peroxidases
family:Catalase-peroxidase KatG
protein:Catalase-peroxidase KatG


superfamily:Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains

protein:Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains


fold:Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains

superfamily:Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains

protein:Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains


class:Membrane and cell surface proteins and peptides

fold:Multidrug efflux transporter AcrB transmembrane domain

superfamily:Multidrug efflux transporter AcrB transmembrane domain

protein:Multidrug efflux transporter AcrB transmembrane domain


class:Alpha and beta proteins (a/b)
fold:Ribonuclease H-like motif
superfamily:Actin-like ATPase domain
family:Actin/HSP70
protein:Actin


superfamily:Metalloproteases ("zincins"), catalytic domain

family:Anthrax toxin lethal factor, N- and C-terminal domains

protein:Anthrax toxin lethal factor, N- and C-terminal domains


protein:Aminopeptidase P, C-terminal domain


family:tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase

protein:tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase


class:All beta proteins
fold:beta-Trefoil
superfamily:Agglutinin
family:Agglutinin
protein:Agglutinin


family:Breast cancer associated protein, BRCA1

protein:Breast cancer associated protein, BRCA1


fold:Uroporphyrinogen III synthase (U3S, HemD)

superfamily:Uroporphyrinogen III synthase (U3S, HemD)

protein:Uroporphyrinogen III synthase (U3S, HemD)


class:All beta proteins
fold:Oncogene products
superfamily:Oncogene products
family:Oncogene products
protein:p14-TCL1


family:Baseplate structural protein gp27

protein:Baseplate structural protein gp27


fold:Phosphoglucomutase, first 3 domains

superfamily:Phosphoglucomutase, first 3 domains


protein:N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone


class:Alpha and beta proteins (a+b)
fold:Secretion chaperone-like
superfamily:Arp2/3 complex subunits
family:Arp2/3 complex subunits
protein:ARPC2 (34 kDa subunit)


family:Serralysin-like metalloprotease, C-terminal domain


superfamily:Necrosis inducing protein 1, NIP1

protein:Necrosis inducing protein 1, NIP1


class:All alpha proteins
fold:Terpenoid synthases
superfamily:Terpenoid synthases
family:Trichodiene synthase
protein:Trichodiene synthase


protein:Antioxidant defense protein AhpD


class:Membrane and cell surface proteins and peptides


protein:Protease Do (DegP, HtrA), C-terminal domains


superfamily:Major surface antigen p30, SAG1


fold:(Phosphotyrosine protein) phosphatases II

superfamily:(Phosphotyrosine protein) phosphatases II

family:Higher-molecular-weight phosphotyrosine protein phosphatases


family:Noncollagenous (NC1) domain of collagen IV

protein:Noncollagenous (NC1) domain of collagen IV


fold:Knottins (small inhibitors, toxins, lectins)


fold:Orange carotenoid protein, N-terminal domain

superfamily:Orange carotenoid protein, N-terminal domain

protein:Orange carotenoid protein, N-terminal domain


superfamily:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC

protein:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC


protein:Internalin B, C-terminal domains


protein:Isomerase domain of glucosamine 6-phosphate synthase (GLMS)


class:All beta proteins
fold:AbrB/MazE/MraZ-like
superfamily:AbrB/MazE/MraZ-like
family:Hypothetical protein MraZ
protein:Hypothetical protein MraZ


fold:Pyruvoyl-dependent histidine and arginine decarboxylases

superfamily:Pyruvoyl-dependent histidine and arginine decarboxylases


class:All alpha proteins
fold:Gametocyte protein Pfg27
superfamily:Gametocyte protein Pfg27
family:Gametocyte protein Pfg27
protein:Gametocyte protein Pfg27


class:All beta proteins
fold:FAS1 domain
superfamily:FAS1 domain
family:FAS1 domain
protein:Fasciclin I


protein:Histone H3 K4-specific methyltransferase SET7/9 catalytic domain


superfamily:Amidase signature (AS) enzymes


fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)

family:Peptidylglycine alpha-hydroxylating monooxygenase, PHM

protein:Peptidylglycine alpha-hydroxylating monooxygenase, PHM


family:Hypothetical protein SPyM3 0169 (SPyM18 0222, SPS0176)

protein:Hypothetical protein SPyM3 0169 (SPyM18 0222, SPS0176)


fold:6-phosphogluconate dehydrogenase C-terminal domain-like

superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like

family:Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain


class:Alpha and beta proteins (a+b)
fold:Hypothetical protein YwqG
superfamily:Hypothetical protein YwqG
family:Hypothetical protein YwqG
protein:Hypothetical protein YwqG


class:Membrane and cell surface proteins and peptides

superfamily:MFS general substrate transporter


superfamily:Formiminotransferase domain of formiminotransferase-cyclodeaminase.

protein:Formiminotransferase domain of formiminotransferase-cyclodeaminase.


fold:P-loop containing nucleoside triphosphate hydrolases

superfamily:P-loop containing nucleoside triphosphate hydrolases


class:All beta proteins
fold:4-bladed beta-propeller
superfamily:Hemopexin-like domain
family:Hemopexin-like domain
protein:Hemopexin


fold:Penicillin-binding protein 2x (pbp-2x), c-terminal domain

superfamily:Penicillin-binding protein 2x (pbp-2x), c-terminal domain

protein:Penicillin-binding protein 2x (pbp-2x), c-terminal domain


family:RNA 3'-terminal phosphate cyclase, RPTC

protein:RNA 3'-terminal phosphate cyclase, RPTC


protein:Insulin receptor substrate 1, IRS-1


protein:Vegetative insecticidal protein 2 (VIP2)


family:Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain

protein:Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain


fold:Common fold of diphtheria toxin/transcription factors/cytochrome f


class:Membrane and cell surface proteins and peptides

fold:Preprotein translocase SecY subunit

superfamily:Preprotein translocase SecY subunit

protein:Preprotein translocase SecY subunit


class:Alpha and beta proteins (a+b)
fold:Ribosomal protein L6
superfamily:Ribosomal protein L6
family:Ribosomal protein L6
protein:Ribosomal protein L6


superfamily:Chlorophyll a-b binding protein


fold:Knottins (small inhibitors, toxins, lectins)


class:Alpha and beta proteins (a+b)
fold:CheC-like
superfamily:CheC-like
family:CheC-like
protein:Chemotaxis protein CheX


fold:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain

superfamily:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain

protein:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain


class:All alpha proteins
fold:Spectrin repeat-like
superfamily:PhoU-like (Pfam 01895)
family:PhoU-like (Pfam 01895)
protein:PhoU homolog TM1734


family:Chlorite dismutase-like (Pfam 06778)


family:FGAM synthase PurL, PurS-like domain

protein:FGAM synthase PurL, PurS-like domain


fold:Kazal-type serine protease inhibitors

superfamily:Kazal-type serine protease inhibitors

protein:Blood-sucking insect-derived tryptase inhibitor


family:Allosteric threonine deaminase C-terminal domain

protein:Allosteric threonine deaminase C-terminal domain


class:Small proteins
fold:BPTI-like
superfamily:BPTI-like
family:Soft tick anticoagulant proteins
protein:Ornithodorin


superfamily:DNA-binding protein LAG-1 (CSL)


superfamily:Sporulation related repeat (SPOR, Pfam 05036)


class:Membrane and cell surface proteins and peptides

superfamily:V-type ATP synthase subunit C


class:Alpha and beta proteins (a+b)
fold:Hypothetical protein TM0160
superfamily:Hypothetical protein TM0160
family:Hypothetical protein TM0160
protein:Hypothetical protein TM0160


class:Alpha and beta proteins (a+b)
fold:Nudix
superfamily:Nudix
family:NADH pyrophosphatase
protein:NADH pyrophosphatase


fold:Putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)

superfamily:Putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)


protein:Hypothetical protein YgfZ, N-terminal domain


superfamily:Vitelline membrane outer protein-I (VMO-I)

protein:Vitelline membrane outer protein-I (VMO-I)


class:All beta proteins
fold:beta-Trefoil
superfamily:STI-like
family:Kunitz (STI) inhibitors
protein:Winged bean albumin 1


class:All alpha proteins
fold:SWIB/MDM2 domain
superfamily:SWIB/MDM2 domain
family:SWIB/MDM2 domain
protein:MDM2


family:Prokaryotic DNA topoisomerase I, a C-terminal fragment

protein:Prokaryotic DNA topoisomerase I, a C-terminal fragment


class:All beta proteins
fold:Neurophysin II
superfamily:Neurophysin II
family:Neurophysin II
protein:Neurophysin II


superfamily:Fumarate reductase respiratory complex transmembrane subunits

family:Fumarate reductase respiratory complex cytochrome b subunit, FrdC

protein:Fumarate reductase respiratory complex cytochrome b subunit, FrdC


superfamily:Periplasmic binding protein-like I


fold:N-terminal domains of the minor coat protein g3p

superfamily:N-terminal domains of the minor coat protein g3p

protein:N-terminal domains of the minor coat protein g3p


fold:Sulfite reductase hemoprotein (SiRHP), domains 2 and 4

superfamily:Sulfite reductase hemoprotein (SiRHP), domains 2 and 4

protein:Sulfite reductase hemoprotein (SiRHP), domains 2 and 4


protein:Nuclear ribonucleoprotein A1 (RNP A1, UP1)


class:All beta proteins
fold:Cyanovirin-N
superfamily:Cyanovirin-N
family:Cyanovirin-N
protein:Cyanovirin-N


class:All beta proteins
fold:Acid proteases
superfamily:Acid proteases
family:Pepsin-like
protein:Pepsin(ogen)


class:All alpha proteins
fold:Chorismate mutase II
superfamily:Chorismate mutase II
family:Allosteric chorismate mutase
protein:Allosteric chorismate mutase


superfamily:Sulfite reductase, domains 1 and 3

protein:Sulfite reductase, domains 1 and 3