--- # Model Selection Policy # Used by model-selection/SKILL.md as the routing and ranking source of truth. # Edit this file to adjust priorities without touching the skill logic. default_output_count: 3 always_include_budget_option: true always_include_frontier_option: true # Scoring weights (must sum to 1.0) weights: task_fit: 0.40 # primary_tasks match modality_fit: 0.20 # input/output/conditioning modality match compute_fit: 0.15 # compute_tier within stated budget openness_fit: 0.10 # open_weights + commercial_use alignment maturity_score: 0.10 # established > recent > experimental deployment_practicality: 0.05 # single_gpu_feasible, no gating, etc. # Penalties applied on top of the weighted score penalties: gated: 0.20 # gated=true and user wants frictionless over_budget_compute: 0.25 # compute_tier exceeds stated budget unknown_commercial_status: 0.15 # commercial_use=unknown when deployment is commercial legacy_model: 0.10 # status=legacy or exclusion_tags contains prefer_*_over_this non_commercial_commercial_deploy: 0.30 # commercial_use=non_commercial_only|research_only when commercial # Default assumed compute budget when none stated default_compute_budget: single_gpu_midmem # Task → ordered candidate list (first is preferred; apply compute filter after) routing: embedding: - esmc_300m # strongest small embedder (non-commercial) - esm2_t33_650m # best commercial default - saprot_650m # structure-aware, if structure available - ankh3_large # multi-task pretrain, strong generalization - prot_t5_xl_enc # T5 ecosystem; slower but competitive - esm2_t30_150m # budget fallback variant_effect_prediction: - esm1v_650m # purpose-built masked-marginal scorer - tranception # autoregressive + retrieval; best on fitness landscapes - saprot_650m # structure-aware variant effect if structure available - esm2_t33_650m # general fallback with PLL scoring - esm2_t6_8m # budget option with PLL scoring fitness_prediction: - tranception - esm1v_650m - esm2_t33_650m sequence_generation: - protgpt2 # established decoder-only baseline - dplm_650m # diffusion; better diversity - esm3_sm_open # generative multimodal (non-commercial) controlled_generation: - esm3_sm_open # best open for structure/function conditioned - dplm2_150m # joint seq+structure, lighter - nv_la_proteina # frontier all-atom (gated, research-only) folding: - esmfold_v1 # fast MSA-free, open weights - boltz_2 # better for complexes / affinity - dplm2_150m # lighter; co-designs sequence + structure inverse_folding: - esm_if1 # purpose-built, small, commercial - dplm_650m # diffusion-based; good diversity - dplm2_150m # joint seq+structure design motif_scaffolding: - dplm_650m - dplm2_150m - nv_la_proteina # frontier all-atom scaffolding binder_design: - boltzgen_1 # purpose-built binder generator - nv_la_proteina # all-atom frontier design - boltz_2 # complex prediction + affinity complex_prediction: - boltz_2 - boltzgen_1 binding_affinity_prediction: - boltz_2 nucleotide_representation: - nucleotide_transformer_v2_500m biomedical_nlp: - biomedbert_base # MIT, PubMed abstracts - biobert_base # Apache 2.0, PubMed + PMC # Hard filter rules (applied before scoring) # Models failing any applicable rule are excluded from candidates. hard_filters: - rule: task_mismatch description: Exclude if task not in model primary_tasks or secondary_tasks - rule: compute_over_budget description: Exclude if compute_tier > stated budget (unless no candidate passes) - rule: gated_frictionless description: Exclude gated models when user explicitly requests frictionless access - rule: commercial_restriction description: Exclude non_commercial_only/research_only models when commercial deployment is implied - rule: wrong_category description: Exclude nucleotide_language_model and biomedical_text_model for protein tasks (and vice versa)