kzkedzierska commited on
Commit
80baadf
·
verified ·
1 Parent(s): 3d0ba1b

Upload README.md with huggingface_hub

Browse files
Files changed (1) hide show
  1. README.md +38 -54
README.md CHANGED
@@ -1,73 +1,57 @@
1
  ---
2
- license: mit
3
- library_name: enhancer-designer
 
 
4
  tags:
5
- - pytorch
6
- - lightning
7
- - genomics
8
- - neuroscience
9
- - regulatory-genomics
10
- - sequence-modeling
11
- - enhancer-design
12
- - sequence-to-function
13
- - basal-ganglia
14
- - macaque
15
- - dilated-cnn
16
- pretty_name: Dilated CNN Macaque Basal Ganglia model
17
  ---
18
 
19
  # AllenInstitute/BG-macaque-dilatedCNN
20
 
21
- Dilated CNN trained on macaque (*Macaca mulatta*) basal ganglia chromatin accessibility data across 58 cell type tracks. Part of the DNA sequence modeling resources associated with the basal ganglia cell atlas package. Published in [Johansen, Fu et al., 2025](https://doi.org/10.64898/2025.12.15.694496).
22
 
23
- ## Model Details
24
-
25
- | Field | Value |
26
- |---|---|
27
- | Architecture | Dilated CNN |
28
- | Species | *Macaca mulatta* (macaque) |
29
- | Brain region | Basal ganglia |
30
- | Number of tracks | 58 |
31
- | Framework | PyTorch Lightning |
32
- | Checkpoint format | `.ckpt` |
33
 
34
- ## Background
 
35
 
36
- This model learns cis-regulatory sequence logic underlying basal ganglia cell type specialization from snATAC-seq-derived accessibility profiles. It can be used to score candidate enhancer sequences, run in silico mutagenesis, or guide sequence design for specific cell types.
37
-
38
- For broader context on the associated multiomic studies and the consensus cell type taxonomy used to define tracks, see the [BG Cell Atlas sequence modeling repository](https://huggingface.co/AllenInstitute/BG-cell-atlas-sequence-modeling).
39
 
40
- ## Availability
 
 
 
 
41
 
42
- This repository is currently private. The `enhancer-designer` codebase is an internal Allen Institute tool with a public release planned in the near future.
43
 
44
- To request early access, please contact **Kasia Kedzierska** at kasia.kedzierska@alleninstitute.org.
 
 
 
 
 
 
 
 
 
 
45
 
46
  ## Usage
47
 
48
  ```python
49
- from enhancerdesigner.models import load_model
50
-
51
- model = load_model("AllenInstitute/BG-macaque-dilatedCNN")
52
- ```
53
-
54
- ## Target Tracks
55
-
56
- The full list of 58 tracks is accessible programmatically after loading:
57
 
58
- ```python
59
  model = load_model("AllenInstitute/BG-macaque-dilatedCNN")
60
- print(model.target_names)
61
  ```
62
-
63
- ## Citation
64
-
65
- ```bibtex
66
- @article{Johansen2025,
67
- title = {Cross-species consensus atlas of the primate basal ganglia},
68
- author = {Johansen, Nelson and Fu, Yuanyuan and others},
69
- journal = {bioRxiv},
70
- year = {2025},
71
- doi = {10.64898/2025.12.15.694496}
72
- }
73
- ```
 
1
  ---
2
+ library_name: regrex
3
+ license: other
4
+ license_name: allen-institute-software-license
5
+ license_link: LICENSE
6
  tags:
7
+ - pytorch
8
+ - lightning
9
+ - genomics
10
+ - regrex
11
+ - neuroscience
12
+ - regulatory-genomics
13
+ - sequence-to-function
14
+ - basal-ganglia
15
+ - macaque
16
+ - dilated_cnn
 
 
17
  ---
18
 
19
  # AllenInstitute/BG-macaque-dilatedCNN
20
 
21
+ Dilated CNN trained on macaque (*Macaca mulatta*) basal ganglia chromatin accessibility across 58 cell-type tracks. Part of the DNA sequence-modeling resources for the basal ganglia cell atlas. Published in [Johansen, Fu et al., 2025](https://doi.org/10.64898/2025.12.15.694496).
22
 
23
+ ### Background
24
+ Learns cis-regulatory sequence logic underlying basal ganglia cell-type specialization from snATAC-seq accessibility profiles. Use it to score candidate enhancers, run in silico mutagenesis, or guide cell-type-specific sequence design.
 
 
 
 
 
 
 
 
25
 
26
+ ### Availability
27
+ Currently private. RegRex (formerly `enhancer-designer`) is an internal Allen Institute tool with a public release planned. For early access contact Kasia Kedzierska (kasia.kedzierska@alleninstitute.org).
28
 
29
+ ## Model Details
 
 
30
 
31
+ - **Architecture:** dilated_cnn
32
+ - **Species:** macaque
33
+ - **Number of tracks:** 58
34
+ - **Framework:** PyTorch Lightning
35
+ - **Checkpoint format:** Lightning .ckpt
36
 
37
+ ## Target Tracks
38
 
39
+ - AMY-SLEA-BNST_D1_GABA
40
+ - AMY-SLEA-BNST_GABA
41
+ - Astrocyte
42
+ - BAM
43
+ - BF_SKOR1_Glut
44
+ - COP
45
+ - Endo
46
+ - Ependymal
47
+ - GPe-NDB-SI_LHX6-LHX8-GBX1_GABA
48
+ - GPe_MEIS2-SOX6_GABA
49
+ - ... (48 more)
50
 
51
  ## Usage
52
 
53
  ```python
54
+ from regrex.models import load_model
 
 
 
 
 
 
 
55
 
 
56
  model = load_model("AllenInstitute/BG-macaque-dilatedCNN")
 
57
  ```